Gel-like composition with mosquito repelling effect as well as preparation method and application of gel-like composition

Abstract

The invention belongs to the technical field of daily necessities, and particularly relates to a gelatinous composition with a mosquito repelling effect as well as a preparation method and application of the gelatinous composition. The gelatinous composition is composed of a phase A, a phase B, a phase C and a phase D, the phase A comprises the following raw materials in percentage by weight: 0.5%-3.0% of a synergist, 1%-5% of a stabilizer and 5%-30% of water; the phase B is prepared from the following raw materials in percentage by weight: 5 to 60 percent of active ingredient and 1 to 30 percent of organic solvent; the phase C comprises the following raw materials in percentage by weight: 2%-8% of plant essential oil, 5%-38% of an oil solvent and 5%-10% of a solubilizer; the phase D is prepared from the following raw materials in percentage by weight: 5 to 11 percent of water, 5 to 20 percent of gel and 1 to 2 percent of water-retaining agent. The gel composition prepared by the invention is long in lasting period, safe and non-toxic.

Description

Technical Field

[0001] This invention belongs to the field of daily necessities technology, specifically relating to a gel-like composition with mosquito-repellent effect, its preparation method, and its application. Background Technology

[0002] In summer, mosquito and insect bites not only cause itchy and swollen skin, but also spread diseases. People usually use mosquito coils, mosquito repellent sprays, and electric mosquito swatters to repel mosquitoes. Mosquito coils have a pungent smell, mosquito repellent sprays have an unpleasant smell, and manually swatting mosquitoes with an electric mosquito swatter is tiring. Therefore, a scented gel that has mosquito-repelling function and natural fragrance is very necessary.

[0003] Tetrafluorobenzenepyrethrin is an organic compound with the chemical formula C. 15 H 12 C 12 F4O2, a colorless crystal with a slight odor, is insoluble in water but soluble in most organic solvents. It is a pyrethroid insecticide with low human toxicity, used for household pest control. Its saturated vapor pressure is 1.1 × 10⁻⁶. -3 Pa (20℃) is relatively volatile.

[0004] For example, Chinese patent CN101702914A discloses a method for preparing filaments by melt-mixing polyethylene resin and insect control agents (pesticides) at 160°C to 300°C. These filaments can be further processed into net-like, rope-like, or yarn-like structures for controlling arthropod pests at room temperature. However, materials prepared by this melt-mixing method require the insecticide to migrate from the resin material to the resin surface for release, a process that is very slow. This makes it unsuitable for spatial insect control and limits its application to contact-type barrier insect prevention.

[0005] For example, Chinese patent CN104273158A discloses a composition for controlling the release of pyrethroids, which can achieve stable release of pyrethroids at room temperature for use in space pest control, especially for the control of flying pests. However, the wax used in this invention as a substance to control insecticide release is difficult to achieve. Wax is an oily solid at room temperature, which easily encapsulates the insecticide, preventing its release. Adding low-volatility solvents also hinders release, resulting in a short duration of effectiveness and reduced mosquito-repellent effect. Furthermore, the invention does not mention the manufacturing process of this composition, making mass production impossible.

[0006] For example, Chinese patent CN103386147A discloses an absorbent product that provides mosquito-repellent and odor-removing properties. It includes a liquid-permeable surface layer, an absorbent body, and a liquid-impermeable bottom layer, arranged sequentially from top to bottom. The liquid-permeable surface layer is composed of non-woven fabric uniformly sprayed with mosquito repellent liquid. The components and contents of the mosquito repellent liquid are: 0.5-2 parts by weight of polyethylene sorbitan monooleate, 1-2 parts by weight of mosquito-repellent plant essential oil, 0.01-0.105 parts by weight of tetrafluorobenzyl ester, 0.5-0.9 parts by weight of menthol, and the balance being polypropylene. However, this invention is unsafe for infants and young children, and its use period is short.

[0007] Therefore, there is an urgent need to research a mosquito-repellent gel composition that is long-lasting, safe, non-toxic, and simple to prepare. This invention constructs a dual controlled-release system of "physical barrier + water slow release" through the synergistic effect of the D-phase gelling agent and water-retaining agent. Simultaneously, combined with the B-phase solvent stabilization design and multiphase stepwise compounding process, it solves the problem of the easy volatility of active ingredients from two dimensions: "inhibiting volatilization momentum" and "constructing a volatilization barrier," ultimately achieving a long-lasting mosquito-repellent effect. Summary of the Invention

[0008] In view of the shortcomings of the prior art, the present invention provides a gel composition with mosquito repellent effect, its preparation method and application.

[0009] To achieve the above objectives, the present invention adopts the following technical solution: On the one hand, the present invention provides a gel-like composition with mosquito-repellent effect, which is composed of phase A, phase B, phase C and phase D; Phase A, by weight percentage of the total gel composition, includes the following raw materials: synergist 0.5%-3.0%, stabilizer 1%-5%, and water 5%-30%; Phase B, by weight percentage of the total gel composition, includes the following raw materials: 5%-60% active ingredients and 1%-30% organic solvents; Phase C, by weight percentage of the total gel-like composition, includes the following raw materials: 2%-8% plant essential oils, 5%-38% oil solvents, and 5%-10% solubilizers; Phase D, by weight percentage of the total gel composition, includes the following raw materials: water 5%-11%, gelling agent 5%-20%, water-retaining agent 1%-2%; Preferably, the synergist is selected from at least one of vitamin B1, limonene, and citronellol; More preferably, the synergist is vitamin B1.

[0010] Preferably, the stabilizer is selected from at least one of Tween-20, lecithin, and glyceryl stearate.

[0011] More preferably, the stabilizer is Tween-20.

[0012] Preferably, the active ingredient is tetrafluorobenzyl ester or a combination of tetrafluorobenzyl ester and α-ethylidene phenylacetaldehyde, wherein the mass ratio of tetrafluorobenzyl ester to α-ethylidene phenylacetaldehyde is 1:5-200, preferably 1:100.

[0013] Preferably, the organic solvent is a green and environmentally friendly organic solvent; the green and environmentally friendly organic solvent is selected from at least one of ethyl acetate, ethylene glycol monobutyl ether, dipropylene glycol dimethyl ether, and dimethyl carbonate.

[0014] More preferably, the organic solvent is selected from ethylene glycol monobutyl ether and dipropylene glycol dimethyl ether.

[0015] Preferably, the oil solvent is selected from at least one of coconut oil, olive oil, and sunflower seed oil.

[0016] More preferably, the oil solvent is sunflower seed oil.

[0017] Preferably, the solubilizer is hydrogenated castor oil PEG-40.

[0018] Preferably, the gel is an air freshener gel, model DC200A, purchased from Qingdao Dehui Marine Biotechnology Co., Ltd.

[0019] Preferably, the water-retaining agent is a water-retaining agent purchased from Qingdao Dehui Marine Biotechnology Co., Ltd., model BF-1.

[0020] Preferably, the plant essential oil is selected from at least one of peppermint oil, lavender oil, lemon eucalyptus oil, and lemongrass oil.

[0021] More preferably, the plant essential oil is lemongrass oil.

[0022] As a preferred embodiment, the mosquito-repellent gel composition comprises the following raw materials: Phase A: Vitamin B1 1%, Tween-20 1%, Deionized water 14%; Phase B: 5% tetrafluorobenzyl ester, 25% dipropylene glycol dimethyl ether; Phase C: 2% lemongrass oil, 15% sunflower seed oil, 5% hydrogenated castor oil PEG-40; Phase D: 11% deionized water, 20% gelling agent, and 1% water-retaining agent.

[0023] On the other hand, the present invention provides a method for preparing the above-mentioned gel-like composition with mosquito-repellent effect, comprising the following steps: (1) Dissolve the prescribed amount of synergist and stabilizer in water to obtain phase A; (2) Mix the prescribed amount of active ingredient with organic solvent to obtain phase B; (3) Dissolve the prescribed amount of plant essential oil and solubilizer in an oil solvent to obtain phase C; (4) Dissolve the prescribed amount of molding agent and water-retaining agent in water, heat to 70℃-80℃, and stir while heating. After complete dissolution, phase D is obtained. (5) When phase A is heated to 70-80℃, add phase C and phase B and stir evenly, then add phase D, stir evenly, pour into a container, and cool to obtain the product.

[0024] Finally, the present invention also provides the application of the above-mentioned gel composition with mosquito-repellent effect in the preparation of mosquito-repellent products.

[0025] Compared with the prior art, the present invention has the following beneficial effects: (1) This invention does not require an additional heat source, power source, or air source. Simply hang the product prepared by the composition in an air-circulating environment to stably and effectively release the insecticide into the air, thereby achieving the effect of repelling mosquitoes.

[0026] (2) The composition prepared by the present invention has a long duration of effect and can keep mosquitoes repelling for 180+ days after opening.

[0027] (3) The present invention uses lemongrass essential oil, which makes people feel happy and has no side effects during the use of the composition.

[0028] (4) The composition prepared by the present invention can be packaged in a plastic bottle, which is inaccessible to infants and children, and is safe and harmless to use. It is safe for pregnant women and infants to use.

[0029] (5) The present invention uses safe and environmentally friendly solvents and does not pollute the ecological environment.

[0030] (6) The preparation process of the present invention is simple and easy to implement, and has the capability for large-scale production.

[0031] (7) The present invention adds a new chemical substance, α-ethylidene phenylacetaldehyde, which works together with tetrafluorobenzyl ester to repel mosquitoes, while reducing the amount of tetrafluorobenzyl ester used.

[0032] (8) This invention constructs a dual controlled-release system of "physical barrier + water slow release" through the synergistic effect of phase D gelling agent and water-retaining agent. At the same time, combined with phase B solvent stabilization design and multiphase stepwise compounding process, the problem of easy volatilization of active ingredients is solved from two dimensions: "inhibiting volatilization power" and "constructing volatilization barrier", and finally the long-lasting mosquito repellent effect is achieved. Attached Figure Description

[0033] Figure 1 Example diagram of a room used to prevent landing rate testing. Detailed Implementation

[0034] The technical solution of the present invention will be clearly and completely described below with reference to specific embodiments. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are not included in this description. All embodiments are within the scope of protection of this invention. Unless otherwise specified, the materials and reagents used are commercially available.

[0035] The gel used in the following examples and comparative examples is an air freshener gel, model DC200A, purchased from Qingdao Dehui Marine Biotechnology Co., Ltd.

[0036] The water-retaining agent used was purchased from Qingdao Dehui Marine Biotechnology Co., Ltd., model BF-1.

[0037] Example 1: A gel-like composition with mosquito-repellent effect The gel composition is composed of the following raw materials by weight percentage of the total gel composition: Phase A: Vitamin B1 1%, Tween-20 1%, Deionized water 14%; Phase B: 5% tetrafluorobenzyl ester, 25% dipropylene glycol dimethyl ether; Phase C: 2% lemongrass oil, 15% sunflower seed oil, 5% hydrogenated castor oil PEG-40; Phase D: 11% deionized water, 20% gelling agent, and 1% water-retaining agent.

[0038] Example 2: A gel-like composition with mosquito-repellent effect The gel composition is composed of the following raw materials by weight percentage of the total gel composition: Phase A: 3% limonene, 5% lecithin, 8% deionized water; Phase B: 1% tetrafluorobenzenesulfuron, 1% ethyl acetate, 10% α-ethylhexyl acetaldehyde; Phase C: Peppermint oil 8%, coconut oil 38%, hydrogenated castor oil PEG-40 10%; Phase D: 4% deionized water, 10% gelling agent, and 2% water-retaining agent.

[0039] Example 3: A gel-like composition with mosquito-repellent effect The gel composition is composed of the following raw materials by weight percentage of the total gel composition: Phase A: Citronellol 0.5%, Glyceryl stearate 1%, Deionized water 20%; Phase B: Tetrafluorobenzenepyrin 0.1%, Ethylene glycol monobutyl ether 30%, α-ethylidene phenylacetaldehyde 20%; Phase C: 2% lavender oil, 5% olive oil, 7.5% hydrogenated castor oil PEG-40; Phase D: 7.4% deionized water, 5% gelling agent, and 1.5% water-retaining agent.

[0040] Example 4: A gel-like composition with mosquito-repellent effect The gel composition is composed of the following raw materials by weight percentage of the total gel composition: Phase A: Vitamin B1 1%, Tween-20 1%, Deionized water 5%; Phase B: 10% tetrafluorobenzenepyrin, 5% dipropylene glycol dimethyl ether, 50% α-ethylidene phenylacetaldehyde; Phase C: 2% lemongrass oil, 6% sunflower seed oil, 6% hydrogenated castor oil PEG-40; Phase D: 8% deionized water, 5% gelling agent, and 1% water-retaining agent.

[0041] Comparative Example 1 The difference from Example 1 is that an equal amount of lemongrass oil was replaced with an equal amount of tea tree oil, and the rest is the same as in Example 1.

[0042] Comparative Example 2 The difference from Example 1 is that an equal amount of tetrafluorobenzyl ester was replaced with an equal amount of α-ethylhexyl acetaldehyde, and the rest is the same as in Example 1.

[0043] Comparative Example 3: A gel-like composition with mosquito-repellent effect The gel composition is composed of the following raw materials by weight percentage of the total gel composition: Phase A: Vitamin B1 5%, Tween-20 0.5%, Deionized water 15%; Phase B: Tetrafluorobenzenepyrin 0.5%, dipropylene glycol dimethyl ether 20%, α-ethylidene phenylacetaldehyde 1%; Phase C: 15% lemongrass oil, 2% sunflower seed oil, and 10% hydrogenated castor oil; Phase D: 10% deionized water, 20% gelling agent, and 1% water-retaining agent.

[0044] The above Examples 1-4 and Comparative Examples 1-3 were prepared according to the following method: (1) Dissolve the prescribed amount of synergist and stabilizer in water to obtain phase A; (2) Mix the prescribed amount of active ingredient with organic solvent to obtain phase B; (3) Dissolve the prescribed amount of plant essential oil and solubilizer in an oil solvent to obtain phase C; (4) Dissolve the prescribed amount of molding agent and water-retaining agent in water, heat to 75°C, and stir while heating. After complete dissolution, phase D is obtained. (5) When phase A is heated to 75°C, add phase C and phase B and stir evenly. Then add phase D, stir evenly, pour into a container, and cool to obtain the product.

[0045] Effect Experiment 1. Evaluation of Indoor Efficacy Tests Referring to the test method of GB / T13917.6-2009, the box method was used for testing. In a 70cm×70cm×70cm transparent glass box, 50 test mosquitoes were collected and placed into the box through the release port for each test. After the test mosquitoes resumed normal activity, the mesh composition at different time points was placed into the center of the glass box through the small door, and the fan was turned on to maintain an airflow speed of 0.2±0.05m / s. The entire box device was immediately sealed, and the timer was started. The number of test mosquitoes knocked down was recorded every 1 minute. The observation period was 20 minutes. The test should be repeated three times or more. The test device should be cleaned after each test. The KT50 value was calculated using the linear weighted regression method based on the repeated test data. When the KT50 value is ≤6min, it is a domestically registered Grade A product. The KT50 values ​​at different time points are shown in Table 1.

[0046] Table 1

[0047] Comparative Example 1, where lemongrass oil was replaced with tea tree oil, showed a shortened duration of effectiveness in the mosquito repellent gel, as indicated by the KT50 score, demonstrating that lemongrass oil enhances the efficacy of the mosquito repellent gel. Comparative Example 2, without the addition of tetrafluorobenzyl, showed a significantly increased KT50 and a significantly reduced duration of effectiveness. Comparative Example 3, with a 1:2 ratio of tetrafluorobenzyl to α-ethylphenylacetaldehyde, also showed an increased median knockout time. Therefore, it is evident that only when all three ingredients are used together, and the ratio of tetrafluorobenzyl to α-ethylphenylacetaldehyde is within the range specified in claim 2, can the optimal mosquito repellent effect be achieved.

[0048] 2. Prevent landing rate test Following the methods in GB / T 13917.10-2009 "Indoor Efficacy Testing and Evaluation of Sanitary Insecticides for Pesticide Registration - Part 10: Simulated Field Tests", we modified the simulated field to test the repellency effect of mosquito repellent gel. The simulated field consisted of two approximately square structures with a volume of 28 m³. 3 The room has a height of at least 2.5m, and the two rooms are connected by adjacent doors. The sample to be tested is suspended in the middle of room 1, approximately 1.5m above the ground. See the example diagram of the test room. Figure 1 .

[0049] Environmental conditions: 27±2℃, 80%±10% relative humidity, equipped with exhaust fans to remove residual active ingredients in the repeated experimental rooms. Mosquitoes were released in room 2, 50 times per release, with each experiment repeated 4 times, for a total of 200 mosquitoes tested.

[0050] During the test, a blank control group was simultaneously tested under the same conditions. The exposure time for both the experimental and control groups was 1 hour. The number of mosquitoes landing on the bound mice was recorded during the exposure period, and the landing prevention rate was calculated. The test results are shown in Table 2 below.

[0051] Landing Denial Rate (%) = ×100% Table 2

[0052] The repellent cabin test yielded similar conclusions to the box test. In Comparative Example 1, replacing lemongrass oil with tea tree oil reduced the landing inhibition rate after 60 days and shortened the duration of the repellent gel's effectiveness, demonstrating that lemongrass oil can enhance the efficacy of the repellent gel. Comparative Example 2 showed that without tetrafluorobenzyl ester, the landing inhibition rate was significantly reduced, and the duration of effectiveness decreased. In Comparative Example 3, a 1:2 ratio of tetrafluorobenzyl ester to α-ethylphenylacetaldehyde resulted in a reduced landing inhibition rate. Therefore, it is evident that only when all three ingredients are used together, and the ratio of tetrafluorobenzyl ester to α-ethylphenylacetaldehyde is within an appropriate range, can the optimal mosquito-repellent effect be achieved.

[0053] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several modifications or equivalent substitutions can be made to the technical solution without departing from the principle of the present invention, and these modifications or equivalent substitutions should also be considered within the scope of protection of the present invention.

Claims

1. A gel-like composition with mosquito-repellent effect, characterized in that, The gel-like composition consists of phases A, B, C, and D; Phase A, by weight percentage of the total gel composition, includes the following raw materials: synergist 0.5%-3.0%, stabilizer 1%-5%, and water 5%-30%; Phase B, by weight percentage of the total gel composition, includes the following raw materials: 5%-60% active ingredients and 1%-30% organic solvents; Phase C, by weight percentage of the total gel-like composition, includes the following raw materials: 2%-8% plant essential oils, 5%-38% oil solvents, and 5%-10% solubilizers; Phase D, by weight percentage of the total gel composition, includes the following raw materials: water 5%-11%, gelling agent 5%-20%, water-retaining agent 1%-2%; The active ingredient is tetrafluorobenzyl ester or is composed of tetrafluorobenzyl ester and α-ethylidene phenylacetaldehyde.

2. The gel-like composition according to claim 1, characterized in that, The mass ratio of tetrafluorobenzenepyrin to α-ethylhexanthaldehyde is 1:5-200.

3. The gel-like composition according to claim 1, characterized in that, The synergist is selected from at least one of vitamin B1, limonene, and citronellol.

4. The gel-like composition according to claim 1, characterized in that, The stabilizer is selected from at least one of Tween-20, lecithin, and glyceryl stearate.

5. The gel-like composition according to claim 1, characterized in that, The organic solvent is a green and environmentally friendly organic solvent, which is selected from at least one of ethyl acetate, ethylene glycol monobutyl ether, dipropylene glycol dimethyl ether, and dimethyl carbonate.

6. The gel-like composition according to claim 1, characterized in that, The oil solvent is selected from at least one of coconut oil, olive oil, or sunflower seed oil.

7. The gel-like composition according to claim 1, characterized in that, The plant essential oil is selected from at least one of peppermint oil, lavender oil, lemon eucalyptus oil, and lemongrass oil.

8. The gel-like composition according to claim 1, characterized in that, The solubilizer is hydrogenated castor oil PEG-40.

9. A method for preparing the gel-like composition according to any one of claims 1-8, characterized in that, Includes the following steps: (1) Dissolve the prescribed amount of synergist and stabilizer in water to obtain phase A; (2) Mix the prescribed amount of active ingredient with organic solvent to obtain phase B; (3) Dissolve the prescribed amount of plant essential oil and solubilizer in an oil solvent to obtain phase C; (4) Dissolve the prescribed amount of gelling agent and water-retaining agent in water, heat and stir at the same time, and obtain phase D after complete dissolution; (5) When phase A is heated to 70-80℃, add phase C and phase B and stir evenly, then add phase D, stir evenly, pour into a container, and cool to obtain the product.

10. The use of the gel composition according to any one of claims 1-8 or the gel composition prepared by the preparation method according to claim 9 in the preparation of mosquito repellent products.

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