Combined system preparation for preventing and treating smoking harm and preparation method thereof

Abstract

According to etiology and pathogenesis characteristics of smoking harm, 29 traditional Chinese medicines including adenophora tetraphylla, blueberries, mulberry leaves, mint and the like are prepared into preparations of different formulas through the steps of cutting, decocting and the like. The compound substitutional tea drink for oral administration and the plaster externally applied to the Tiantu acupoint, the Danzhong acupoint and the Shuangfeishu acupoint form an integrated combined system preparation for overall conditioning and prevention, and the purposes of relieving the developed symptoms and preventing injuries are achieved through comprehensive overall regulation and intervention by means of the self overall regulation and control mechanism of the five-internal-organ integrated system of the human body. The invention further discloses a preparation method of the compound substitutional tea drink for oral administration and the plaster externally applied to the Tiantu acupoint, the Danzhong acupoint and the Shuangfeishu acupoint. The combined system preparation has the effects of clearing lung and promoting salivation, relieving sore throat and detoxifying, moistening dryness and reducing phlegm, relieving cough and asthma, reinforcing qi and nourishing yin, and promoting blood circulation to remove meridian obstruction, and is used for preventing and treating smoking harm.

Description

A combined system formulation for preventing the harms of smoking and its preparation method Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a combined system formulation for preventing and treating the harms of smoking, and also to a method for preparing the aforementioned combined system formulation. Background Technology

[0011] Smoking is one of the major public health risks worldwide, harming not only human health but also society. Tobacco contains the toxic substance nicotine. One gram of nicotine can kill 300 rabbits or 500 mice. Injecting a human with 50 milligrams of nicotine is fatal. Besides nicotine (which is addictive), tobacco contains over 4,000 chemical components, of which at least 250 are known to be harmful and over 50 are known to be carcinogenic.

[0012] Long-term smoking can damage multiple systems, including the respiratory and cardiovascular systems, increasing the risk of lung cancer, chronic obstructive pulmonary disease (COPD), and coronary heart disease. The harmful effects of smoking are numerous; it not only destroys the health and lives of smokers but also pollutes the air and endangers others.

[0013] (1) Lung diseases: Cigarettes release 38 toxic chemicals when burned, among which the main harmful components are tar, carbon monoxide, nicotine, and irritating smoke. Smoking is most harmful to the respiratory tract, and tar damages the mouth, throat, trachea, and lungs. Tar in tobacco smoke deposits on the cilia in the lungs, damaging their function, increasing phlegm, and causing chronic bronchial diseases, which can easily lead to laryngitis, tracheitis, emphysema, pulmonary heart disease, lung cancer, and other diseases.

[0014] (2) Cardiovascular diseases: Carbon monoxide in cigarettes reduces the oxygen content in the blood, causing related diseases such as coronary heart disease, hypertension, cerebrovascular disease, and peripheral vascular disease. Smoking causes coronary artery constriction, reducing or blocking blood supply and causing myocardial infarction. Smoking can increase adrenaline, causing a faster heartbeat, increased cardiac load, and affecting blood circulation, leading to more than 20 diseases including cardiovascular and cerebrovascular diseases, diabetes, sudden death syndrome, decreased respiratory function, and stroke.

[0015] (3) Smoking causes cancer: When smoking, smoke enters through the mouth, passes through the throat, trachea, and bronchi, and enters the bloodstream. Smoking can cause men to lose their Y chromosome, increasing their risk of cancer. Studies have found that smoking is the fastest and most abundant way to produce free radicals; each puff of smoke produces at least 100,000 free radicals, leading to cancer and many chronic diseases. Smoking is one of the major contributing factors to lung cancer; smokers are 13 times more likely to develop lung cancer than non-smokers, and approximately 85% of lung cancer deaths are caused by smoking.

[0016] (4) Smoking can also lead to osteoporosis and premature menopause. Smoking makes teeth yellow and causes bad breath. Smoking harms both the smoker and those who are passively exposed to it; passive smokers are five times more likely to be harmed than smokers.

[0017] (5) Smoking can cause digestive system diseases. Nicotine in tobacco can reduce the tone of the pyloric sphincter, which can lead to acid reflux and, in severe cases, digestive system ulcers.

[0018] (6) Smoking is even more harmful to women than to men. Smoking can cause menstrual disorders, low estrogen levels and osteoporosis in women. Smoking during pregnancy may also cause spontaneous abortion.

[0019] (7) The Harm of Smoking to Intelligence. Smoking can affect a person's attention. Some people believe that smoking can refresh the mind, eliminate fatigue, and trigger inspiration, but these are completely unscientific. Experiments have shown that smoking seriously affects a person's intelligence and memory, thereby reducing work and study efficiency.

[0023] Smoking and Disease

[0024] (1) Smoking and Respiratory Diseases: Cigarette smoke first comes into contact with the respiratory mucosa. The dry, hot smoke can cause an irritating cough, while simultaneously making these mucosa very dry and chronically congested. To keep the respiratory mucosa moist, the mucosal cells compensate by secreting excessive mucus. This excess mucus, when expelled, is what we commonly call phlegm. Long-term smokers commonly experience chronic cough and excessive phlegm. In addition, the smoke particles in cigarette smoke are 50,000 times more numerous than those in the air, and these particles contain many harmful substances. These substances can poison and damage the cilia, and can cause the secreted mucus to coagulate, thus rendering the cilia and mucus unable to resist and protect themselves. As a result, a large number of toxins and bacteria can easily enter and stagnate in the bronchi and alveoli, which can cause respiratory inflammation. Long-term heavy smoking can cause chronic bronchitis and even emphysema.

[0025] (2) Smoking and coronary heart disease

[0026] Smoking is a significant risk factor for coronary heart disease (CHD). Epidemiological studies have found that smoking increases the incidence of CHD; even light smoking increases the incidence of cardiovascular events compared to non-smokers. Smoking can induce acute coronary syndrome, stable angina, sudden cardiac death, and stroke, while also increasing the risk of aortic and peripheral artery atherosclerosis, leading to intermittent claudication and abdominal aortic aneurysm. Vasoconstriction disorders, inflammation, and lipid disorders caused by smoking are important factors in the development and progression of atherosclerosis. Smoking stimulates the sympathetic nervous system, leading to a series of hemodynamic changes, such as increased heart rate, coronary resistance, myocardial contractility, and myocardial oxygen consumption. These short-term effects can raise the ischemic threshold of the coronary arteries in smokers, thereby increasing the risk of acute cardiovascular events. Smoking can also cause coronary artery spasm, and cigarette smoke increases blood viscosity, leading to thrombus formation due to abnormalities in platelet function, anticoagulation, and fibrinolytic factors—a theory that has been widely confirmed. Research indicates that smokers have a 70% higher mortality rate from coronary heart disease than non-smokers. Furthermore, the more cigarettes smoked, the longer the duration of smoking, the earlier the age of starting smoking, and the deeper the smoke is inhaled into the bronchi, the greater the risk of coronary heart disease and the higher the mortality rate. Experts and scholars believe that tobacco and its smoke contain various compounds related to the development of coronary heart disease, primarily nicotine and carbon monoxide. Carbon monoxide may play a more significant role than nicotine because its affinity for hemoglobin is approximately 250 times greater than that for oxygen. Increased carbon monoxide levels in the blood reduce the oxygen-carrying capacity of hemoglobin, leading to organ hypoxia. In patients with coronary heart disease, this can induce angina, myocardial infarction, and sudden cardiac death. In addition, nitrogen oxides can bind with oxygen, reducing oxygen-containing hemoglobin. Furthermore, thiocyanate can inhibit cellular respiration and promote the damage of nicotine and carbon monoxide to the heart and blood vessels.

[0027] (3) Smoking and Pulmonary Hypertension: Pulmonary hypertension is a malignant pulmonary vascular disease characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, ultimately leading to right heart failure and death. Smoking significantly increases left ventricular thickness, reduces cardiac pumping function, and thus increases the risk of heart failure. Smoking directly leads to the production of oxidative free radicals, myocardial mitochondrial damage, and nicotine-induced release of free fatty acids, all of which contribute significantly to the development of heart failure. Increasing evidence suggests a link between arterial stiffness and heart failure. Smoking increases atherosclerotic stiffness through endothelial cell damage, producing superoxide, increasing the production and release of endothelin, leading to endothelial dysfunction, and changes in pro-inflammatory cytokines and adipokines. Smoking causes cardiac damage through two important, interconvertible mechanisms: first, the direct adverse effects on the myocardium lead to smoking-related cardiomyopathy; second, it indirectly causes cardiac damage and remodeling through complications such as atherosclerosis and hypertension caused by smoking.

[0028] Traditional Chinese Medicine Etiology, Pathogenesis, Clinical Manifestations, and Advantages of Traditional Chinese Medicine in the Prevention and Treatment of the Harmful Effects of Smoking

[0029] Although Traditional Chinese Medicine (TCM) does not have a specific disease name for "the harm of smoking," based on its clinical manifestations, it can be categorized under "lung dryness," "phlegm retention," "cough," "pulmonary atrophy," and "cardiac obstruction." TCM theory holds that tobacco is a "pungent, hot, and drying toxin," and long-term inhalation easily leads to dryness and heat damaging the lungs, generating phlegm and heat, resulting in symptoms such as sore throat and yellow phlegm; it also depletes qi and yin, causing fatigue and night sweats; the lungs and spleen are closely related ("the spleen is the source of phlegm, and the lungs are the receptacle of phlegm"), and smoking affects the spleen and stomach's digestive function, leading to internal phlegm and dampness, resulting in symptoms such as excessive phlegm, chest tightness, loss of appetite, and abdominal distension; prolonged illness can also affect the collaterals, causing blood stasis and obstructing the meridians, resulting in fixed chest pain.

[0030] Therefore, traditional Chinese medicine prescriptions for preventing and treating the harms of smoking should be based on the following basic principles: clearing the lungs and promoting body fluid production, relieving sore throat and detoxifying, moistening dryness and resolving phlegm, relieving cough and asthma, replenishing qi and nourishing yin, and promoting blood circulation and unblocking collaterals.

[0031] 1. Tobacco poisoning damages the throat: Tobacco is hot in nature, and the smoke burns the throat, causing dry and itchy throat, mild cough, sore throat, hoarseness, a foreign body sensation in the throat, and frequent throat clearing;

[0032] 2. Dryness and heat injure the lungs: Tobacco is hot in nature, and the smoke burns the lung vessels, depletes lung yin, and causes the lungs to lose their ability to clear and purify, resulting in symptoms such as dry cough, dry throat, scanty and sticky sputum, or sputum with blood streaks;

[0033] 3. Internal generation of phlegm-heat: Prolonged exposure to tobacco toxins transforms into heat, which in turn condenses fluids into phlegm. This phlegm-heat obstructs the lungs, manifesting as symptoms such as coughing up thick yellow phlegm, chest tightness, and shortness of breath.

[0034] 4. Qi and Yin deficiency: Long-term smoking leads to decreased lung function (shortness of breath when climbing stairs, susceptibility to colds, weak cough), prolonged cough depletes qi and damages yin, resulting in insufficient lung qi and deficiency of yin fluid, manifested as shortness of breath, fatigue, dry mouth and throat, weak voice, and other symptoms.

[0035] 5. Blood stasis and obstruction of collaterals: Tobacco toxins enter the blood, and heat scorches body fluids, hindering blood flow and forming blood stasis, leading to arteriosclerosis and microcirculatory disorders. Symptoms closely related to cardiovascular and cerebrovascular diseases, such as dizziness, limb numbness, and chest tightness, may appear.

[0036] Clinically, the following four syndrome types are commonly seen: 1. Lung Yin Deficiency Type: The dryness and heat of tobacco consume lung yin, and the lungs lose their moisture, resulting in dry throat and mouth, which worsens at night, cough with hoarseness, weak voice, dry cough with little phlegm, or little sticky phlegm that is difficult to expectorate, night sweats, hot palms and soles, red tongue with little or no coating; and thready and rapid pulse.

[0037] II. Phlegm-Dampness Accumulating in the Lungs Type: Smoking causes dysfunction of the spleen and stomach, leading to the internal generation of phlegm-dampness that accumulates in the lungs. Symptoms include a heavy cough, abundant and easily expectorated phlegm that is white, sticky, and rattling; chest tightness, epigastric fullness, loss of appetite, sallow complexion, fatigue, loose stools, and abdominal distension; a pale and swollen tongue with a white and greasy coating; and a slippery or weak and slow pulse.

[0038] 3. Lung heat and phlegm excess type: Smoking aggravates lung heat, which burns body fluids and produces phlegm. The combination of phlegm and heat causes a coarse cough, thick yellow phlegm that is difficult to expectorate, dry mouth and bitter taste; red and swollen throat with pain, flushed face and red eyes, chest tightness and distending pain; dry stools and dark yellow urine; red tongue with yellow and greasy coating; slippery and rapid pulse.

[0039] IV. Qi Deficiency and Blood Stasis Type: Long-term smoking depletes qi and damages the collaterals, resulting in qi deficiency and insufficient blood circulation, leading to blood stasis. Symptoms include a weak cough, chest tightness and sighing, which worsen after activity; chest tightness and stabbing pain in a fixed location, which worsens with pressure; accompanied by palpitations, insomnia, sallow complexion, shortness of breath, reluctance to speak, fatigue, spontaneous sweating, and aversion to wind; a purplish-dark tongue or petechiae, varicose veins under the tongue, and a choppy or wiry pulse. This type is commonly seen in people who have smoked for a long time (more than 20 years), middle-aged and elderly people, or those with underlying diseases such as coronary heart disease and chronic bronchitis.

[0040] Short-term heavy smoking often leads to lung heat and phlegm accumulation; long-term smoking often leads to lung yin deficiency and phlegm-dampness accumulation in the lungs; elderly people or those with underlying diseases, such as coronary heart disease, often have qi deficiency and blood stasis, while those with diabetes are prone to yin deficiency and those with hypertension are prone to blood stasis. Smokers often have concurrent symptoms, such as: lung yin deficiency with phlegm-dampness accumulation, manifested as dry cough with a small amount of white phlegm and a thin, greasy tongue coating; lung heat and phlegm accumulation with qi deficiency, manifested as thick yellow phlegm accompanied by shortness of breath and fatigue, etc.

[0041] Traditional Chinese medicine (TCM) has unique advantages in preventing and treating the harms of smoking. Its core approach targets the pathogenesis of tobacco-induced lung damage ("dryness and heat," "internal accumulation of phlegm and dampness," and "stagnation of qi and blood"), intervening through multiple pathways such as clearing the lungs and detoxifying, moistening dryness and resolving phlegm, strengthening the spleen and removing dampness, nourishing qi and yin, and promoting blood circulation and removing blood stasis. It can also resist oxidation, reduce the damage to the lungs caused by free radicals produced by smoking, help eliminate toxins accumulated from smoking, improve respiratory inflammation, alleviate clinical symptoms caused by smoking, improve lung function, assist in physical recovery, and significantly reduce the risk of respiratory, cardiovascular, and pulmonary hypertension-related diseases in smokers. This achieves the preventive and therapeutic goals of "preventing damage" and "relieving existing symptoms."

[0042] The link between SOD and the harms of smoking

[0043] Smoking produces a large number of superoxide anion free radicals, which attack lung cells and respiratory mucosa, damaging cell structure. Long-term accumulation exacerbates oxidative stress in the lungs, inducing discomfort such as dry throat and cough. SOD, or superoxide dismutase, is an important antioxidant enzyme in the body. Its core function is to eliminate superoxide anion free radicals, reducing oxidative damage to cells (especially lung cells). SOD can rapidly decompose superoxide anion free radicals, reducing their damage to the lungs. However, the amount of SOD synthesized by the body decreases with age or long-term smoking. In such cases, food-grade ingredients can be used to indirectly help increase SOD activity and regulate the body's antioxidant system.

[0076] There is an urgent need for a safe, effective, convenient, and easy-to-use preparation to prevent the harms of smoking, addressing the health needs of the general public. This preparation should be highly safe, applicable in a wide range of scenarios, suitable for a broad population, conform to people's dietary habits, have a superior taste, be easy to use, portable, and easy to maintain for long-term use. Summary of the Invention

[0077] To address the shortcomings of existing technologies, this invention selects most of the Chinese medicinal materials from a list of 106 medicinal and edible plants, and combines them with an oral preparation and an external preparation for use at the Tian Tu, Tan Zhong, and bilateral Fei Shu acupoints. This provides a healthy, natural, safe, effective, and non-toxic combination system preparation. Taking advantage of the aforementioned medicinal and edible properties, the oral preparation further incorporates flavoring ingredients such as rose (fragrant), jujube (sweet), and blueberry (natural fruit aroma), which impart natural fragrances (such as rose, jujube, and fruit aromas) to neutralize and balance the bitterness of other herbs, resulting in a mild and palatable taste with a lighter medicinal flavor. It also enriches the nutritional content and is more easily accepted by the public. One objective of this invention is to provide a combined systemic preparation for preventing and treating the harms of smoking. The application employs the following technical solution: Different formulations of traditional Chinese medicine are used to prepare an oral compound tea and external plasters for acupoints such as Tian Tu, Tan Zhong, and bilateral Fei Shu. This forms an integrated systemic preparation for overall conditioning and prevention. Relying on the body's own holistic regulatory mechanism of the five internal organs, and guided by meridian-guiding herbs, the various herbs are transported through the meridians to the affected area, exerting their conditioning and preventative effects. This harmonizes the internal organs, qi and blood, yin and yang, transforming the body from an unbalanced state to a balanced state. It also protects areas unaffected by pathogens and promptly interrupts disease transmission pathways, preventing the development or worsening of diseases. Under the comprehensive conditioning and preventive effects of drugs (the four properties, five flavors, ascending and descending properties of traditional Chinese medicine) and meridians (acupoint stimulation, communication, circulation of qi and blood, sensory conduction, and balance regulation), as well as nerve and humoral regulation, bio-holographic and generalized effects, amplification and diversity, relying on the body's own holistic regulatory mechanism of the five internal organs system through multiple pathways, links, levels, and targets, this comprehensive holistic regulatory intervention can resist oxidation, reduce the damage of free radicals produced by smoking to the lungs, help eliminate toxins accumulated from smoking, and improve respiratory inflammation. It can alleviate clinical symptoms caused by smoking, improve lung function, promote physical improvement and disease recovery, and significantly reduce the risk of respiratory, cardiovascular, and pulmonary hypertension-related diseases in smokers, achieving the preventive and therapeutic goals of "preventing damage" and "relieving existing symptoms." A second objective is to provide a method for preparing the aforementioned combined system formulation.

[0078] In response to the etiological and pathological characteristics of the harms of smoking, this invention is a combined systemic preparation for the prevention and treatment of the harms of smoking, including a compound herbal tea for oral administration and a plaster for external application to the Tian Tu, Tan Zhong, and bilateral Fei Shu acupoints. Each has a different formula, and the components and their weight ratios of the raw materials are as follows: A. Compound herbal tea for oral administration: 1-4g of Nan Sha Shen, 1-4g of Mai Dong, 1-4g of dried lily scales, 1-4g of dried blueberries, 0.5-1g of Jie Geng, 0.5-1g of dried double-petaled rose petals, 0.5-1g of dried jujube (pitted), 0.5-1g of frost-covered mulberry leaves, 0.5-1g of dried peppermint leaves, 0.1-0.5g of Huang Qi, and 0.1-0.5g of tangerine peel (aged for three years).

[0079] The formula contains *Adenophora stricta*, which enters the lung and stomach meridians. It is suitable for people with lung yin deficiency and excessive phlegm caused by smoking. Its functions are: 1. Sweet and slightly cold, it nourishes lung yin and moistens lung dryness, and also clears lung heat. It is used for yin deficiency cough, lung heat dry cough, dry cough with little phlegm, dry throat and hoarseness, etc., and also has the function of resolving phlegm, which can be used for those with dry lungs and sticky phlegm, and difficulty expectorating phlegm; 2. Sweet and cold, it nourishes yin, nourishes stomach yin and clears stomach heat, and is used for stomach yin deficiency with heat, dry mouth and throat, constipation, poor appetite and vomiting, etc., and also... It can replenish the spleen qi, and has the effect of replenishing both qi and yin for the syndrome of deficiency of both stomach yin and spleen qi; modern pharmacological research has proven that: (1) it has immunomodulatory effect and anti-tumor effect; (2) it has the effect of scavenging free radicals; (3) it has antitussive and expectorant effects; Ophiopogon japonicus is sweet, slightly bitter and slightly cold, and enters the heart, lung and stomach meridians. It can replenish the lung and stomach yin fluids consumed by smoking and relieve dry mouth and tongue, dry cough without phlegm; its functions are: 1. Sweet and cold to nourish yin, enters the lung meridian, and is good at nourishing lung yin and clearing lung yin. Hot, suitable for symptoms such as dry nose and throat, dry cough with little phlegm, coughing up blood, sore throat and hoarseness due to yin deficiency and lung dryness; Second, sweet and moist, bitter and cold in nature, enters the stomach meridian, and is good at benefiting the stomach, generating fluids and clearing heat; Third, enters the heart meridian, can nourish heart yin, clear heart heat, and has the effect of relieving irritability and calming the mind; Modern pharmacological research has proven that: (1) Ophiopogon japonicus contains Ophiopogon japonicus polysaccharide and flavonoids, which have direct antioxidant effects, can remove free radicals produced by smoking, reduce the consumption of SOD, and indirectly maintain the balance of the antioxidant system in the body; (2) Ophiopogon japonicus polysaccharide can promote humoral immunity and cellular immunity, and induce a variety of cytokines, and exert anti-cancer effects by enhancing immune function; (3) Ophiopogon japonicus polysaccharide has anti-hypoxia protective effect against cerebral ischemia injury; (4) It has the effect of improving blood rheology and anticoagulation; Lily, enters the heart and lung meridians, and its functions are: First, sweet and slightly cold, can nourish lung yin, clear lung heat, and has the effects of nourishing yin and clearing lung, moistening dryness and relieving cough. It is used for dry cough with little phlegm, hemoptysis, or dry throat and hoarseness due to yin deficiency and lung dryness with heat; secondly, it can nourish the yin of the heart and lungs, clear the heat of the heart and lungs, and also has a certain calming effect; thirdly, it is used to assist various pungent and warm medicines to prevent them from being too warm and dry, and to cut off the heat-generating disease trend; modern pharmacological research has proven that lily can resist oxidation and relieve lung tissue damage; blueberry, sweet and sour in taste, is neutral to slightly cool in nature when dried, mildly nourishing without being drastic, and without the disadvantages of being cold and greasy; its functions are: firstly, it enters the liver meridian, can clear the liver, protect the eyes and improve vision, generate fluids and moisten dryness, nourish yin and protect the eyes, and can relieve the fluid deficiency and dry eyes caused by yin deficiency; secondly, it can nourish yin and moisten dryness, generate fluids and quench thirst, and the sweetness of the tea can directly replenish body fluids and relieve dryness and discomfort. It is suitable for the body fluid deficiency and dryness caused by smoking, manifested as dry mouth and tongue, dry and itchy throat, dry skin, and constipation. Third, it soothes the throat and protects the voice. The warm and soothing taste of the tea, combined with the thirst-quenching properties of blueberries, gently relieves congestion and dryness of the throat mucosa, reduces the feeling of a foreign object in the throat, and is non-irritating, thus regulating and relieving throat discomfort. Fourth, the blueberry tea has a natural fruity aroma, and its liver-cleansing and dryness-relieving properties can help alleviate irritability and anxiety. Fifth, it can moisturize dryness and clear heat. The tea can gently clear mild internal heat without the drawbacks of bitterness and coldness that can harm the stomach.Modern research has proven that blueberries are hailed as "super fruits". Their core value lies in their high content of anthocyanins and diverse nutritional combinations, with multiple effects including antioxidant, eye protection, heart protection, brain health improvement, and metabolic regulation: 1. Antioxidant and free radical scavenging effect: Blueberries are recognized as high-antioxidant fruits. The antioxidant components can be stably dissolved in the tea beverage, playing a role in daily anti-aging and health care. Components such as anthocyanins, polyphenols, vitamin C, and vitamin E work together to inhibit lipid peroxidation, scavenge excess free radicals in the body, reduce oxidative damage of free radicals to cells, delay cell aging, and at the same time enhance the body's antioxidant capacity; reduce chronic inflammation and oxidative stress, indirectly reducing the risks of cardiovascular diseases, cancers, and neurodegenerative diseases. 2. Effect on the brain: Anthocyanins can cross the blood-brain barrier, protect neurons, improve short-term memory and cognitive function; delay brain aging, reduce the risk of Alzheimer's disease, and are beneficial for cognitive maintenance in middle-aged and elderly people; improve attention and reaction speed, and enhance learning and work efficiency. 3. Effect on the cardiovascular system: ① Regulate blood lipids: Dietary fiber and flavonoids reduce bad cholesterol (LDL) and increase good cholesterol (HDL); ② Protect vascular endothelium: Enhance vascular elasticity and permeability, reducing the risk of arteriosclerosis; ③ Assist in blood pressure control: Phenolic substances help dilate blood vessels, having an auxiliary improvement effect on mild hypertension; ④ Anti-thrombotic: Inhibit platelet aggregation, reducing the risk of thrombosis formation. 4. Metabolic regulation effect: Soluble fiber can nourish beneficial bacteria in the intestine, produce short-chain fatty acids, and enhance the intestinal barrier; insoluble fiber and fruit acids can gently stimulate intestinal peristalsis, promote intestinal peristalsis, and improve intestinal dryness and constipation. 5. Immune enhancement effect: ① Vitamin C and anthocyanins work together to enhance the activity of immune cells and strengthen the body's resistance; ② Reduce inflammatory responses, having an auxiliary relieving effect on allergic rhinitis, asthma, etc.; ③ Consumption after exercise can reduce muscle damage and soreness and accelerate recovery. 6. Eye protection and eyesight improvement effect: Blueberries are rich in anthocyanins (especially delphinidin and cyanidin). These substances are water-soluble strong antioxidants and can be fully dissolved in the tea soup after brewing. They can penetrate the blood-retinal barrier, protect rhodopsin on the retina, and reduce damage to the eyes by blue light and ultraviolet rays; at the same time, they can promote blood circulation in the eyes, relieve ciliary muscle tension, and relieve visual fatigue. 7. Manganese contained participates in energy metabolism and protects nerves. 8. Organic acids and polysaccharide components in blueberries can stimulate the oral mucosa to secrete saliva, and at the same time their property of nourishing yin and moistening dryness can improve the state of fluid deficiency in the body. Platycodon grandiflorum belongs to the guiding drug of the lung meridian and returns to the lung meridian.Functions: 1. It is pungent and bitter, opening up and dispersing lung qi, with a good expectorant effect. It is an essential medicine for lung meridian qi-level diseases, treating cough with excessive phlegm and difficulty in expectorating phlegm, regardless of whether it is cold or hot. 2. It is dispersing and ascending, which can benefit lung qi to expel purulent phlegm that is congested in the lungs. 3. It acts as a vessel, carrying other medicines upward, guiding them into the lung meridian, raising lung qi, and promoting urination, thus benefiting lung qi and achieving the effect of nourishing the earth to generate metal. 4. It can clear the lungs and expel pathogens to benefit the throat, open the voice, and treat hoarseness. It can also clear heat to prevent the adverse effects of sweet and warm tonics that cause dryness and heat. 5. It can dispel wind and release the exterior, clearing the lungs and expelling pathogens to benefit the throat, open the voice, and treat hoarseness. 6. It opens up and disperses lung qi to promote urination and defecation, preventing the adverse effects of tonics that promote dampness and stagnation. 7. It can ascend and descend, and can both disperse and guide, so that no residual stagnation remains inside or outside. Rose, with its fragrant aroma, has the following functions: 1. It promotes qi and relieves depression: It enters the liver and spleen meridians, can soothe the liver and gallbladder qi, and invigorate the spleen and stomach. It can be used to treat symptoms caused by liver and stomach disharmony and qi stagnation; secondly, it can regulate blood and menstruation: rose can regulate liver qi and harmonize blood. It can be used to treat symptoms caused by liver stagnation; thirdly, it is bitter and dispersing, warm and unblocking, and has the effects of promoting blood circulation, removing blood stasis, and relieving pain; jujube has a slightly fragrant aroma and sweet taste, and can eliminate the disadvantages of the cold nature of ginseng, ophiopogon japonicus, lily, and mulberry leaf in damaging the spleen and stomach; functions: firstly, it is sweet and warm, enters the spleen and stomach meridians, can tonify the spleen and replenish qi, and is suitable for symptoms such as poor appetite, fatigue, and loose stools caused by spleen and stomach weakness and qi deficiency; secondly, it can nourish heart blood and calm the mind; thirdly, it is sweet and mild, and can moderate the harshness or toxicity of other drugs and protect the spleen and stomach; modern pharmacological research has proven that: ① it enhances immunity: jujube contains a variety of vitamins and minerals. It contains substances and bioactive materials that can promote leukocyte production, increase serum albumin, and enhance the body's resistance. It also has a certain alleviating effect on bone marrow suppression after radiotherapy and chemotherapy in cancer patients. Astragalus polysaccharides can promote RNA and protein synthesis, promote cell growth, prolong lifespan, improve skin blood circulation and nutrition, and revitalize necrotic cells. Secondly, it improves blood circulation: rich in vitamin P, it can maintain capillary permeability, improve microcirculation, and is beneficial to cardiovascular health. Its folic acid and B vitamins can lower homocysteine ​​levels. Reduces the risk of cardiovascular and cerebrovascular diseases; ③ Antioxidant and anti-cancer: Contains flavonoids, anthocyanins and other polyphenolic compounds, which can scavenge free radicals, delay aging, and some studies have shown that certain components can inhibit the proliferation of cancer cells and even promote the transformation of cancer cells into normal cells; Mulberry leaves are sweet, bitter and cold, and enter the lung meridian. They can clear lung heat, relieve lung heat cough and dry throat caused by smoking, and improve dry eyes; The functions are: 1. This product is sweet and cold and light in nature, and can disperse wind-heat; 2. This product is bitter and cold to clear lung heat, and sweet and cold to moisten lung dryness, and is used for lung heat or dryness. Heat injures the lungs, causing cough with little phlegm, yellow in color and thick in consistency, or dry cough with little phlegm, itchy throat, etc.; Third, this product can not only disperse wind-heat, but also, being bitter and cold, enters the liver to clear liver heat, and is sweet and moistening to nourish yin and improve eyesight, treating red, sore, and watery eyes; Fourth, this product can also cool the blood and stop bleeding, treating hemoptysis caused by blood heat; Peppermint, entering the lung and liver meridians, can guide the medicine upward to the throat, and its functions are: First, it is pungent and cool to induce sweating, clears and disperses, is light and ascending, fragrant and opens the orifices, effectively dispersing wind-heat, clearing the head and eyes, benefiting the throat, and promoting detoxification and rash eruption, dispelling wind and relieving itching; Second, it enters the liver meridian and can soothe the liver and regulate qi; Third, it is fragrant and dispels foul odors.It can also resolve dampness, harmonize the stomach, and aid digestion. Modern pharmacological research has proven that: ① Menthol and menthone contained in peppermint have a cooling and soothing effect, which can reduce mucosal irritation and relieve discomfort such as dry throat, sore throat, itchy throat, and foreign body sensation; ② The volatile components of peppermint can quickly freshen breath and mask the smell of smoke. At the same time, its slightly cool taste can inhibit the growth of oral bacteria and improve bad breath caused by smoking; ③ The cool aroma of peppermint can stimulate the senses, refresh the mind, and help relieve the drowsiness and lethargy that are common in long-term smokers.Astragalus membranaceus (Huang Qi) is sweet and slightly warm in nature, and enters the spleen and lung meridians. Its functions are as follows: 1. Entering the lung meridian, it tonifies lung qi, treating lung qi deficiency, weak cough, shortness of breath, thin and clear sputum, and low voice with reluctance to speak; 2. Entering the spleen meridian, it is a key herb for tonifying spleen qi, addressing both the root cause (spleen and qi) and the symptoms (diuresis and edema), treating spleen deficiency and impaired water metabolism; 3. It nourishes blood and, through tonifying qi, also helps generate blood, thus commonly used to treat blood deficiency or deficiency of both qi and blood; 4. It tonifies qi to promote blood circulation and relieve pain, treating chest pain and heart pain due to qi deficiency and blood stasis; 5. Through its qi-tonifying and blood-nourishing effects, it strengthens the body's resistance, promoting pus drainage, tissue regeneration, and wound healing; 6. It strengthens the spleen, tonifies qi, generates fluids, and quenches thirst; 7. It tonifies the lung and spleen... Qi, benefits the body's defenses and strengthens the exterior; 8. This product can replenish qi, raise yang, and lift prolapse; 9. It can replenish qi to control blood, treating spleen deficiency that fails to control blood; Modern pharmacological research has proven that: ① Astragalus polysaccharides can promote RNA and protein synthesis, making cells grow vigorously, prolonging their lifespan, improving skin blood circulation and nutritional status, and restoring vitality to necrotic cells; ② Enhance immune function; ③ Astragalus decoction has a protective effect on the kidneys, eliminates proteinuria, and has a diuretic effect, and has a bidirectional regulatory effect on blood pressure; ④ Astragalus decoction, polysaccharides, and saponins have protective and promoting effects on hematopoietic function; ⑤ It has anti-fatigue, low-temperature resistance, anti-radiation, anti-inflammatory, lipid-lowering, blood sugar-lowering, anti-tumor, and liver-protecting effects; ⑥ It is effective against Staphylococcus aureus, Streptococcus pneumoniae, and lysozyme. Streptococcus sanguinis, Shigella dysenteriae, anthrax bacillus, and Corynebacterium diphtheriae have antibacterial effects and can fight influenza viruses; ⑦ Astragalus total saponins have positive inotropic effects, dilate coronary and renal blood vessels, have a cardiotonic effect, promote systemic blood circulation, and improve microcirculation; ⑧ Astragalus can stabilize cell membranes, resist aging, fight free radicals, resist oxidation, and protect lung tissue; ⑨ Inhibit platelet aggregation; Tangerine peel, enters the spleen and lung meridians, suitable for smokers to regulate the spleen and stomach, can resolve phlegm and dampness accumulation caused by smoking, and relieve phlegm and dampness cough; its functions are: 1. It is a qi-regulating medicine of the spleen and lung meridians, pungent, bitter, warm, and fragrant, can promote movement and descend, can regulate qi and invigorate the spleen, regulate the middle jiao and relieve diaphragm, dry dampness and resolve phlegm to treat the root cause of phlegm; 2. Pungent It is warm and enters the lungs and chest, which can promote qi circulation, relieve pain and treat chest pain caused by phlegm and qi stagnation, chest tightness, shortness of breath, etc.; Third, it is pungent and aromatic, warm and bitter, enters the spleen and stomach meridians, promotes qi circulation, relieves bloating and dries dampness, and can treat abdominal distension, poor appetite and vomiting and diarrhea caused by spleen and stomach qi stagnation and dampness obstruction; Fourth, it has bitter and descending properties, and can treat vomiting and hiccups; Modern pharmacological research has proven that: (1) it can relieve cough and eliminate phlegm; (2) it can relieve asthma and relax bronchial smooth muscle; (3) it can inhibit bacteria; (4) it can fight inflammation; (5) it can excite or inhibit and bidirectionally regulate gastrointestinal motility; (6) it can promote the secretion of digestive juices; (7) it can inhibit platelet aggregation, fight tumors, fight oxidation, strengthen the heart, etc.; Chenpi can eliminate the symptoms of dampness accumulation, spleen deficiency and dampness, cough and phlegm caused by Nan Sha Shen, Mai Dong, and Bai He. When these herbs are combined, they work through multiple pathways, such as clearing the lungs and generating fluids, relieving sore throat and detoxifying, moistening dryness and resolving phlegm, relieving cough and asthma, replenishing qi and nourishing yin, and promoting blood circulation and unblocking collaterals. This achieves a balance of ascending and descending functions, strengthens the body's resistance and eliminates pathogens, restores the function of the internal organs, and heals all symptoms on their own.

[0080] The preparation method for the compound herbal tea substitute includes the following steps:

[0081] I. Pretreatment: 1. Preparation of the four herbs: Adenophora stricta, Ophiopogon japonicus, Platycodon grandiflorus, and Astragalus membranaceus: ① Cleaning and impurity removal: Weigh out each of the four herbs according to the ingredient ratio, place them separately in a vegetable washing basket, and rinse quickly 1-2 times under running water to remove surface dirt, dust, and other residual impurities. Note: Do not soak for a long time, otherwise the effective ingredients will be lost, affecting the tea's effect; ② Softening and cutting: After draining the rinsed herbs, place them in a clean container, cover with a damp cloth, and let stand for 1-2 hours or soak in warm water (30-40℃) for 10-15 minutes to soften them for easier cutting; The standard for judging the degree of softening is that they can be cut by hand and are not hard in the core. After draining the softened Adenophora stricta, Ophiopogon japonicus, Platycodon grandiflorus, and Astragalus membranaceus, place them separately on a cutting board and slice them into 2-3 mm thick oblique slices (thin slices have a larger contact area with water than thick slices or whole pieces, making it easier for the active ingredients to dissolve). Slice them as evenly as possible so that the active ingredients can be extracted more quickly during brewing, resulting in a more uniform taste. ③ Drying (for easier storage): Spread the sliced ​​herbs evenly on a bamboo mat or gauze and let them air dry naturally in a well-ventilated, cool, and dry place. Turn them over every 2-3 hours to prevent localized dampness and mold. If the weather is humid, a dryer can be used at a low temperature (controlled at 40-50℃) to avoid damaging the active ingredients with high temperatures. The standard for drying is that the herbs are brittle and easily broken.

[0082] II. Preparation of dried lily scales: Take dried lily scales and rinse them quickly in running water 1-2 times to remove surface dust and residual impurities. Do not soak for a long time (lilies contain a lot of mucilage and polysaccharides, and prolonged soaking will cause the loss of effective ingredients); after rinsing, take them out and soak them in warm water for 10 minutes to soften the texture of the scales (soak until the scales are slightly unfolded, no need to soak until fully expanded), take them out and drain the water, remove the remaining brown stem (the stem has a bitter taste and affects the flavor of the tea), and dry them for later use.

[0083] III. Preparation of dried blueberries: Place dried blueberries in a fine sieve and rinse quickly with running water for 10-20 seconds to remove surface dust, residual fruit pieces and impurities. Do not soak for a long time (the core nutrients in blueberries, such as anthocyanins and polyphenols, are water-soluble, and prolonged soaking will lead to a large loss, reducing the conditioning effect of the tea). After rinsing, drain the water immediately and dry for later use.

[0084] IV. Preparation of Dried Rose Flowers: Place dried rose flowers in a fine sieve and rinse quickly with running water for 10-20 seconds to remove surface dust and impurities. Do not soak (rose petals are delicate, and soaking will cause a significant loss of aroma and nutrients). After rinsing, immediately remove the flowers and lay them flat on a clean gauze to drain. Remove any remaining calyxes and stems (stems have a slightly astringent taste and will affect the flavor of the tea). Dry the flowers and set aside. If the petals are clumped together, gently separate them with your fingers to allow them to fully unfurl during brewing.

[0085] V. Preparation of dried jujubes: Soak jujubes in warm water for 5 minutes to soften the skin wrinkles. Gently brush off surface dust and residual impurities with a soft brush. Remove the pits with a pitter and cut into 0.5 cm thick slices (slicing increases the contact area with water, making it easier for the active ingredients to dissolve, and also avoids the hard texture of whole jujubes when brewed). Dry them for later use.

[0086] VI. Preparation of Mulberry Leaves: Take mulberry leaves and rinse them quickly in clean water 1-2 times. Do not soak them for too long (to prevent the loss of effective ingredients such as flavonoids and alkaloids). Rinse off the surface dust, insect eggs, and mud. After rinsing, drain the water to avoid residual water causing the tea soup to be cloudy. Remove the petioles and withered leaf stems. If using whole mulberry leaves, cut them into 0.5 cm wide strips (cutting them into strips increases the contact area with water, making it easier for the effective ingredients to be extracted). Dry them for later use.

[0087] VII. Preparation of Dried Mint Leaves: Take dried mint leaves, place them in a fine sieve, and rinse quickly with running water for 5-10 seconds to remove surface dust and residual flower stems. Do not soak (mint leaf volatile oils are easily soluble in water; prolonged soaking will cause loss of aroma and medicinal properties). Spread the washed and drained mint leaves evenly on a baking tray and bake in an oven at 40℃ for 5 minutes, until the leaves are slightly dry and the aroma is more mellow (temperatures exceeding 50℃ will destroy the volatile oils). After cooling, seal and store for later use.

[0088] 8. Preparation of Dried Tangerine Peel: Soak dried tangerine peel in warm water for 5-10 minutes to soften its texture and dissolve surface dust and residual impurities. Use a clean, soft-bristled brush to gently scrub the surface of the tangerine peel and the white pith inside (the white pith is dry and has a bitter taste; scraping it off will make the taste milder. You can scrape off some of the white pith, but scraping it completely will result in the loss of some qi-regulating components). Rinse it quickly with clean water again, drain the water, and cut it into 0.5 cm wide strips (cutting it into strips makes it easier for the effective components to be extracted). Dry it and set it aside.

[0089] II. Place all the pre-treated medicinal materials into a mixer and mix thoroughly. Then, measure 15g per bag and pack them into corn fiber tea bags or non-woven fabric tea bags. After heat sealing, the product is obtained.

[0090] The three Chinese herbs mentioned above—Southern Glehnia root, dried double-petaled rose flowers, and mulberry leaves—can be replaced by the following herbs to achieve the same therapeutic effect: 1-4 parts of Southern Glehnia root can be replaced by an equal amount of Northern Glehnia root, Polygonatum odoratum, or Lycium barbarum to achieve the same therapeutic effect; 0.5-1 part of dried double-petaled rose flowers can be replaced by an equal amount of Salvia miltiorrhiza, Curcuma longa, Carthamus tinctorius, Prunus persica, or Rosa rugosa to achieve the same therapeutic effect; 0.5-1 part of mulberry leaves can be replaced by an equal amount of Chrysanthemum morifolium or Lonicera japonica to achieve the same therapeutic effect.

[0091] B. Tian Tu acupoint: Wood butterfly 0.5-2, Sterculia lychnophora 0.5-2, loquat leaf 0.5-1, Platycodon grandiflorus 0.5-1, Trichosanthes kirilowii 0.5-1, Arctium lappa 0.1-0.5, Chrysanthemum 0.1-0.5.

[0092] The herb *Oroxylum indicum* is bitter, sweet, and cool in nature. It enters the lung, liver, and stomach meridians. Its functions are: 1. Being bitter, sweet, and cool, it clears lung heat and soothes the throat, making it a commonly used medicine for sore throat, especially for hoarseness. It treats sore throat and hoarseness caused by pathogenic heat damaging yin; it also clears lung heat, resolves phlegm, and stops coughs, used to treat coughs due to lung heat. 2. Being sweet and mild, and bitter and purging, it enters the liver and stomach meridians, soothing the liver and stomach and relieving pain, treating liver qi stagnation, liver and stomach pain, etc. *Sterculia lychnophora* is sweet and cold in nature. It enters the lung and large intestine meridians. The functions are as follows: 1. This product is sweet, cold, and light in nature. It can clear heat and moisten the lungs to promote lung qi, moisten the lungs and resolve phlegm, benefit the throat and open the voice. It is used to treat ① lung heat stagnation causing sore throat, hoarseness, dry throat and cough without phlegm; ② external wind-heat causing cough and hoarseness; ③ cough with thick phlegm due to lung heat damaging body fluids, difficult to expectorate, or dry cough without phlegm, dry throat and constipation. 2. This product is smooth and moistening in nature. It can promote bowel movement, clear heat and relieve constipation due to lung heat and intestinal dryness, headache and red eyes. Modern pharmacological research has shown that: 1. Sterculia lychnophora extract has a contractile effect on vascular smooth muscle, can improve mucosal inflammation, and reduce spasmodic pain; 2. The infusion has antiviral, antibacterial and anti-inflammatory effects; 3. This product has a certain promoting effect on specific immune function. Loquat leaf, bitter and slightly cold, enters the lung and stomach meridians. It can relieve lung heat and dry cough and stomach heat and vomiting caused by smoking. Its functions are: 1. This product is bitter and cold, and enters the lung meridian to purge lung qi. When qi is lowered, fire is reduced, and when fire is reduced, phlegm is eliminated. 2. It is bitter and slightly cold, and enters the stomach meridian to clear stomach heat, lower stomach qi and stop vomiting. Platycodon root has the same function as A. It is used in compound tea substitutes taken orally. Trichosanthes root is sweet, slightly bitter, and slightly cold, and enters the lung and stomach meridians. Its functions are as follows: 1. This herb is sweet, slightly bitter, and slightly cold. It can clear excess heat in the lung and stomach meridians, and also generate fluids and quench thirst. 2. This herb enters the lung meridian, clearing lung heat and moistening lung dryness. It treats dryness and heat damaging the lungs, causing dry cough with little phlegm, blood in the phlegm, or cough with asthma and hemoptysis due to dryness and heat damaging the lungs and injuring both qi and yin. 3. This herb is good at clearing excess heat in the lungs and stomach, generating fluids and quenching thirst. It treats internal accumulation of heat, dryness damaging fluids, or internal heat causing thirst and injuring both qi and yin. 4. This herb can clear heat, purge fire, and detoxify. It can also reduce swelling, drain pus, and heal sores. It treats the initial redness, swelling, heat, and pain of sores. If pus has not yet formed, it can make the sores dissipate. If pus has formed, it can make the sores ulcerate and drain pus. Burdock seed is pungent, bitter, and cold. It enters the lung and stomach meridians. It disperses wind-heat, promotes lung function and eliminates phlegm, benefits the throat and promotes rash eruption, and detoxifies and reduces swelling. Its functions are as follows: First, this product is bitter and cold in nature. It has the properties of clearing and descending while being ascending and floating. It can disperse wind-heat and relieve heat toxicity. It has the effects of clearing heat and detoxifying, reducing swelling and relieving sore throat. Therefore, it can be used to treat heat toxicity diseases such as sore throat and swollen throat.Because of its slippery and laxative properties, it is especially suitable for those with constipation and heat in the stool, as mentioned above. Secondly, this herb is pungent and bitter, and its cold nature clears heat. While dispersing, it also has a descending effect, functioning to disperse wind-heat, effectively clearing the lungs and resolving phlegm, and soothing the throat. Therefore, it is frequently used for wind-heat colds with red, swollen, and painful throat, or cough with excessive phlegm. Thirdly, this herb clears and disperses, dispersing wind-heat and releasing heat toxins to promote the eruption of rashes. Chrysanthemum, sweet, bitter, and slightly cold, enters the lung and liver meridians, clearing lung heat caused by smoking, relieving slight throat swelling and dry mouth, and improving eye discomfort. Its functions are: First, this herb is pungent and dispersing, and its light nature allows it to reach... Firstly, this herb has a clear, rising nature, is slightly cold and clears heat, and can disperse wind-heat in the lung meridian. Secondly, this herb is pungent and bitter, slightly cold and clears heat, entering the liver meridian, which can both disperse wind-heat in the liver meridian and clear liver heat to improve eyesight. Thirdly, this herb is bitter and slightly cold, and can clear heat and detoxify. Modern pharmacological research has proven that: 1. It contains chrysanthemum flavonoids and volatile oils, which can synergistically scavenge free radicals, relieve lung heat and dry throat caused by smoking, and form an antioxidant defense line together with SOD; 2. It has inhibitory effects on Staphylococcus aureus, influenza virus, etc., and has significant anti-inflammatory effects; 3. It has the effect of dilating coronary arteries, increasing coronary blood flow, and increasing myocardial oxygen consumption. The combined effects of these herbs clear heat and cool the blood, purge fire and detoxify, disperse nodules and soothe the throat, reduce swelling and relieve pain, thus eliminating pathogens and toxins, clearing the lungs and throat, unblocking the qi mechanism, and thus curing various symptoms.

[0093] The raw materials for the external plaster may also include: a matrix, such as honey, beeswax, etc., and transdermal penetration enhancers, such as azone, etc. The preparation process also includes a drug carrier for the plaster, such as: medical coated nonwoven fabric, impermeable membrane and impermeable ring patch, release paper, etc.

[0094] The preparation method of the external plaster includes the following steps:

[0095] (1) Add water and decoct half of each of the seven herbs: Oroxylum indicum, Malva nut, loquat leaf, Platycodon grandiflorus, Trichosanthes kirilowii, Arctium lappa and Chrysanthemum. The specific steps are as follows: Weigh each herb according to the ingredient ratio, take half of each of the seven herbs: Oroxylum indicum, Malva nut, loquat leaf, Platycodon grandiflorus, Trichosanthes kirilowii, Arctium lappa and Chrysanthemum, add water and decoct twice. The decoction time is preferably 1-1.5 hours each time. Combine the decoctions and concentrate them into a clear paste. The relative density of the clear paste is preferably 1.21-1.30 (50-60℃).

[0096] (2) Take the remaining parts of the 7 herbs in step (1) and crush them into fine powder A, such as: crushed into fine powder A of 80-200 mesh;

[0097] (3) Mix the clear paste in step (1) with the fine powder A in step (2), dry it, and then pulverize it into fine powder B that is acceptable for ointment. The specific steps are as follows: mix the fine powder A in step (2) evenly into the clear paste in step (1), put it into a drying oven, dry it at a temperature below 60°C, so that the moisture content is below 6%, and after cooling the material to room temperature, pulverize it into fine powder B of 80-200 mesh and weigh it.

[0098] (4) Take an appropriate amount of honey and heat it until the surface is covered with large reddish-brown bubbles. Add an appropriate amount of beeswax to melt it. Then add the fine powder B and transdermal agent from step (3) in batches, stirring while adding. After mixing evenly, make a paste and apply it to the plaster. The ointment preparation process is a standard procedure, with the optimal method being as follows: Take 30-80% honey by weight of fine powder B, heat it to 119-122℃, ensuring the water content is below 10% and the density is around 1.40. When the surface is covered with large, reddish-brown, glossy bubbles, add 10-30% beeswax by weight of fine powder B and melt it. Filter the mixture and cool it to 58-82℃. While stirring continuously, slowly add fine powder B. At 45-55℃, while stirring continuously, add 1-2% azone by weight of fine powder B and continue stirring until fully mixed and a uniformly colored paste is formed. Spread the paste onto the seepage-proof membrane inside the seepage-proof ring in the middle of the adhesive-coated non-woven base fabric, cover it with release paper, and package it to obtain the product.

[0099] C. Apply plaster to the Tanzhong acupoint: Salvia miltiorrhiza 0.5-2, Platycodon grandiflorus 0.5-2, Inula japonica 0.5-1, Glycyrrhiza uralensis 0.5-1, Paeonia lactiflora 0.5-1, Lilium brownii 0.5-1, Fritillaria thunbergii 0.5-1, Phragmites communis 0.1-0.5, Trichosanthes kirilowii 0.1-0.5, Citrus reticulata 0.1-0.5, Poria cocos 0.1-0.5.

[0100] The formula contains Danshen (Salvia miltiorrhiza), which is bitter and slightly cold in nature; it enters the Heart and Liver meridians. Its functions are: 1. Due to its bitter and purgative properties, it enters the Heart and Liver meridians, primarily affecting the blood. It effectively invigorates blood circulation, removes blood stasis, regulates menstruation, relieves pain, and promotes tissue regeneration. It moves without breaking the flow, making it a key medicine for treating poor blood circulation and blood stasis. 2. Entering the Heart and Liver blood levels, it is highly mobile, invigorating blood circulation, removing blood stasis, and relieving pain. It is a key medicine for treating blood stasis syndrome. 3. Due to its cold nature, it enters the blood level, cooling and invigorating the blood, and dispersing blood stasis and reducing swelling. It can be used for carbuncles and boils caused by heat toxins and blood stasis. 4. Due to its cold nature, it enters the Heart meridian, clearing heat from the heart, cooling the blood, relieving irritability, and calming the mind. Modern pharmacological research shows that: 1. Danshen can resist arrhythmia, dilate coronary arteries, increase coronary blood flow, and regulate blood... 1. Lipids, anti-atherosclerosis; 2. Improves microcirculation, enhances hypoxia tolerance, and protects the myocardium; 3. Dilates blood vessels and lowers blood pressure; 4. Reduces blood viscosity, inhibits platelet aggregation, and counteracts thrombosis; 5. Protects hepatocyte damage, promotes hepatocyte regeneration, and has anti-liver fibrosis effects; 6. Improves kidney function and protects against ischemic kidney injury; 7. Has anti-tumor and anti-fatigue effects; 8. Has anti-inflammatory, anti-allergic, analgesic, and sedative effects; Platycodon grandiflorus has the same function as A. in compound herbal teas taken orally; Inula japonica is bitter, pungent, salty, and slightly warm, and enters the lung, spleen, stomach, and large intestine meridians. Its functions are as follows: First, its bitter taste can purify and descend lung qi, while its pungent taste can disperse and promote circulation, thus restoring the lung's function of regulating qi. Second, it effectively lowers stomach qi and stops vomiting and belching. Third, its salty taste enters the kidneys, guiding qi downwards to its root, allowing phlegm or fluid in the stomach to descend and be expelled through the turbid passages, preventing it from rising upwards and affecting the lungs, thus restoring the lungs' clear and deficient function. In summary, it can nourish the lungs, stomach, and kidneys, and ensure smooth flow in the upper, middle, and lower jiaos; it tonifies while promoting circulation. The combination of Platycodon grandiflorus and Inula japonica, one ascending and one descending, regulates the other tonifying herbs, ensuring they tonify without stagnation of qi. Licorice root enters the heart, lung, spleen, and stomach meridians, and its functions are: First, it is sweet and moistening, entering the lung meridian, and can eliminate phlegm, stop coughing, and relieve asthma. It is used for various types of cough and asthma, whether caused by cold, heat, deficiency, or excess, and is suitable for both with and without phlegm; secondly, its sweetness can tonify deficiency, entering the spleen and stomach meridians, and can replenish the spleen and stomach deficiencies to benefit the middle qi; thirdly, it enters the heart meridian, and can tonify the heart qi, benefit qi and restore the pulse; fourthly, it excels at detoxification, and can clear heat and detoxify; fifthly, its sweet taste can soothe, and it is also good at relieving spasms and pain; sixthly, it is sweet and neutral, with a mild medicinal nature, and when used with various cold, heat, tonifying, and purging drugs, it can mitigate the strong effects or reduce toxic side effects, and harmonize all medicines; white peony root is bitter, sour, and slightly cold. It enters the liver and spleen meridians, and its functions are: 1. It is sour in taste and mainly enters the liver meridian, benefiting the yin and blood of the liver; 2. It astringes yin and stops sweating, treating spontaneous sweating and night sweats; 3. It can astringe liver yin with its sourness, nourish blood, soften the liver, and relieve pain; 4. Its sour and cold nature astringes yin and harmonizes the nutritive qi, preventing pungent and dispersing drugs from damaging yin. It works with pungent and dispersing drugs, one dispersing and the other astringing, with both movement and stillness, harmonizing the nutritive qi and wei qi, so that the exterior is relieved and the interior is harmonized; 5. When combined with licorice, the sweet and bitter flavors complement each other, harmonizing the interior and relieving urgency. Its sour and sweet flavors transform into yin, nourishing lung fluids and soothing lung qi.Modern pharmacological studies have confirmed that it can relieve bronchospasm; lily has the same function as A. in compound herbal teas taken orally; Fritillaria thunbergii, bitter and cold, enters the lung and heart meridians, can resolve lung heat and dry phlegm caused by smoking, and relieve symptoms of dry and itchy throat, and scanty, sticky, and difficult-to-expectorate phlegm; its functions are: 1. This herb is bitter and purgative, and is good at clearing heat and phlegm, lowering lung qi, and can inhibit airway hyperresponsiveness; 2. Bitter and purgative, it clears heat and toxins, resolves phlegm and dissipates nodules and carbuncles, and can treat phlegm-fire stagnation syndrome; Reed rhizome enters the lung and stomach meridians. Sweetness can generate fluids and nourish yin, while coldness can clear heat. It can clear lung heat, eliminate phlegm and pus, moisten dryness and relieve cough, generate fluids and quench thirst, and relieve irritability. In the middle, it can clear stomach heat and stop vomiting. In the lower, it can promote urination and draw heat out through urine. The whole Trichosanthes kirilowii fruit is sweet, cold and moistening. It clears lung heat, moistens lung dryness and can resolve phlegm. It can also promote qi circulation and disperse stagnation to widen the chest, and moisten the intestines to relieve constipation, so that lung heat can be discharged from the large intestine. The function of dried tangerine peel is the same as in compound tea substitutes taken orally in A. Poria cocos enters the heart, lung, spleen and kidney meridians. Its functions are as follows: 1. It has a sweet and bland taste. Sweetness can nourish, and blandness can drain. Its medicinal properties are mild, so it can both dispel pathogens and support the body's vital energy. It can treat various types of edema, including those caused by cold, heat, deficiency, and excess. 2. It is good at draining dampness, preventing dampness from accumulating and phlegm from forming, thus treating the root cause of phlegm. 3. Its sweet taste enters the spleen meridian, which can strengthen the spleen and replenish the middle jiao, promote diuresis and drain dampness, and allow the clear to ascend and the turbid to descend in the middle jiao. 4. It nourishes the heart and spleen and calms the mind and spirit. Tangerine peel and Poria can eliminate the symptoms of dampness accumulation, spleen deficiency and dampness draining, cough and excessive phlegm caused by Adenophora stricta, Ophiopogon japonicus, and Lilium brownii. The combination of these herbs, with their bitter and pungent properties, regulates the ascending and descending of qi, and combines attack and tonification to address the deficiency and excess. It promotes the flow of qi and clears the lungs, nourishes the lungs, and strengthens the spleen and lungs ("earth generates metal"). When the body's vital energy is strong and pathogens are eliminated, the lung's regulatory function is restored, qi flows smoothly, phlegm is eliminated, cough stops, and all symptoms heal themselves.

[0101] The raw materials for the external plaster may also include: (same as B. Tian Tu acupoint)

[0102] The preparation method of the external plaster includes the following steps:

[0103] (1) Add water to decoct half the amount of each of the 11 herbs: Salvia miltiorrhiza, Platycodon grandiflorus, Inula japonica, Glycyrrhiza uralensis, Paeonia lactiflora, Lilium brownii, Fritillaria thunbergii, Phragmites communis, Trichosanthes kirilowii, Citrus reticulata, and Poria cocos. The specific steps are as follows: Weigh each herb according to the ingredient ratio, and take half the amount of each of the 11 herbs: Salvia miltiorrhiza, Platycodon grandiflorus, Inula japonica, Glycyrrhiza uralensis, Paeonia lactiflora, Lilium brownii, Fritillaria thunbergii, Phragmites communis, Trichosanthes kirilowii, Citrus reticulata, and Poria cocos. The rest is the same as B. Tian Tu acupoint (1).

[0104] (2) Take the remaining parts of each of the 11 herbs in step (1) and crush them into fine powder A, such as: crushed into fine powder A of 80-200 mesh;

[0105] (3) Same as B. Tian Tu acupoint (3);

[0106] (4) Same as B. Tian Tu acupoint (4).

[0107] D. Apply plaster to both Lung Shu acupoints: Platycodon grandiflorus 0.5-2g, Tussilago farfara 0.5-1g, Peucedanum praeruptorum 0.5-1g, Lilium brownii 0.5-1g, Angelica sinensis 0.1-0.5g, Panax quinquefolius 0.1-0.5g, Astragalus membranaceus 0.1-0.5g, Citrus reticulata 0.1-0.5g.

[0108] 1. Platycodon grandiflorus in the formula is a guiding herb for the lung meridian, and its function is the same as that in the Tian Tu acupoint A; Tussilago farfara is a lung meridian, which is pungent and moistening, warm but not drying, and is good at moistening the lungs, lowering qi and stopping cough. It can be used to treat cough regardless of whether it is caused by external or internal factors, cold or heat, deficiency or excess, or the length of the course of the disease; Peucedanum praeruptorum is a lung meridian. Functions: 1. This product is pungent and bitter, cold in nature and clears heat, suitable for cough and wheezing with thick yellow phlegm due to phlegm-heat obstructing the lungs and failure of the lungs to disperse and descend; 2. It is pungent and slightly cold in nature, and can disperse wind-heat, clear the lungs, resolve phlegm and stop cough; Modern pharmacological research has proven that it can significantly increase respiratory mucus secretion for a long time, showing expectorant, antiasthmatic, antitussive, vasodilator, antiplatelet aggregation, increase coronary blood flow, reduce myocardial oxygen consumption, reduce myocardial contractility, resist heart failure, and lower blood pressure; it also has antibacterial, anti-inflammatory, sedative, antispasmodic, anti-allergic, and anti-ulcer effects; Lily has the same function as A. in compound tea substitutes taken orally; Angelica sinensis enters the liver, heart, and spleen meridians, and its functions are: 1. It is sweet and pungent in taste, and can both nourish blood and invigorate blood, and is a "qi medicine in blood", which can treat cough and shortness of breath. ① For treating coughs caused by external pathogens: "Using the blood-nourishing herb Angelica sinensis to nourish the blood will harmonize the blood and regulate the defensive qi." Harmonizing the blood and defensive qi will stop the cough. ② For treating coughs caused by internal injury: For those with yin deficiency and yang lacking support, using the blood-nourishing herb Angelica sinensis to replenish yin will balance yin and yang, lower qi, and stop the cough. II. Nourishing blood to moisten the intestines and promote bowel movements. Modern pharmacological research has proven that Angelica sinensis can improve pulmonary circulation, restore elasticity, and relieve cough and asthma symptoms. American ginseng, entering the heart, lung, and kidney meridians, has the following functions: 1. Sweet in taste and nourishing, cool in nature, entering the lung meridian, it is good at benefiting lung qi and nourishing lung yin, clearing lung heat, suitable for shortness of breath, cough with little sputum, or blood in sputum caused by heat consuming lung qi and yin, as well as dryness and heat damaging the lungs, dry throat, coughing up blood, etc.; 2. It can replenish heart qi. It nourishes the heart's yin, improving palpitations, chest pain, insomnia, and excessive dreaming caused by deficiency of both qi and yin in the heart; it also benefits the spleen's qi and nourishes spleen yin; thirdly, it can replenish qi, generate fluids, and clear heat, making it suitable for symptoms caused by heat damaging qi and fluids; modern pharmacological research has proven that it enhances the function of the central nervous system, protects the cardiovascular system, regulates blood pressure, lowers blood lipids, inhibits the formation of atherosclerosis, enhances immunity, has anti-tumor effects, lowers blood sugar, and has sedative effects; the effects of Astragalus membranaceus and Citrus reticulata are the same as those of the Tian Tu acupoint A. The effects of these herbs are the same as those of the Tian Tu acupoint A. When these herbs are combined, their bitter and pungent properties are used to regulate the ascending and descending functions, and their attacking and tonifying effects are combined to address the deficiency and excess, promoting dispersion, clearing and descending, replenishing qi and yin, generating fluids and moistening the lungs, restoring the lung's regulatory function, smoothing qi, eliminating phlegm and stopping cough, and thus curing various symptoms.

[0109] The raw materials for the external plaster may also include: (same as B. Tian Tu acupoint)

[0110] The preparation method of the external plaster includes the following steps:

[0111] (1) Add water to decoct half the amount of each of the eight herbs: Platycodon grandiflorus, Tussilago farfara, Peucedanum praeruptorum, Lilium brownii, Angelica sinensis, Panax quinquefolius, Astragalus membranaceus, and Citrus reticulata. The specific steps are as follows: Weigh the herbs according to the ingredient ratio, and take half the amount of each of the eight herbs: Platycodon grandiflorus, Tussilago farfara, Peucedanum praeruptorum, Lilium brownii, Angelica sinensis, Panax quinquefolius, Astragalus membranaceus, and Citrus reticulata. The specific steps are as follows: Weigh the herbs according to the ingredient ratio, and take half the amount of each of the eight herbs: Platycodon grandiflorus, Tussilago farfara, Peucedanum praeruptorum, Lilium brownii, Angelica sinensis, Panax quinquefolius, Astragalus membranaceus, and Citrus reticulata. The rest is the same as B. Tian Tu acupoint (1).

[0112] (2) Take the remaining parts of the 8 herbs in step (1) and crush them into fine powder A, such as: crushed into fine powder A of 80-200 mesh;

[0113] (3) Same as B. Tian Tu acupoint (3);

[0114] (4) Same as B. Tian Tu acupoint (4).

[0115] This combination of various herbs, administered orally as a tea substitute and externally applied to the Tian Tu, Tan Zhong, and bilateral Fei Shu acupoints, forms a systematic preparation targeting the pathogenesis of smoking-related harms. It leverages the body's own holistic regulatory mechanism, integrating the five internal organs, through a synergistic application of regulation, prevention, and treatment. This comprehensive approach addresses both internal and external factors, achieving a dynamic balance of Yin and Yang, Qi and Blood, and the orderly flow of Qi and Blood through the meridians. It helps eliminate toxins accumulated from smoking, improves respiratory inflammation, and protects the respiratory mucosa; it enhances SOD activity to scavenge free radicals, providing antioxidant protection and reducing lung damage from free radicals produced by smoking, protecting the lungs and cardiovascular system, and lowering the risk of pulmonary hypertension; it improves the body's immunity and overall health, thus achieving the goals of "relieving existing symptoms" and "preventing damage."

[0116] The combined system preparations for preventing the harm of smoking prepared using the above methods include oral tea substitutes, each packaged in individual sachets, with each sachet containing 15-18 grams; and external patches, each patch containing 1-10 grams of medication.

[0117] The combined system formulation for preventing and treating the harms of smoking of the present invention has the following functions: clearing the lungs and promoting body fluid production, relieving sore throat and detoxifying, moistening dryness and resolving phlegm, relieving cough and asthma, replenishing qi and nourishing yin, and promoting blood circulation and unblocking collaterals.

[0118] Dosage and administration: 1. Oral compound herbal tea: Take one pre-packaged tea bag and place it in a clean glass or ceramic pot (do not use metal cups). Pour in 250-500mL of boiling water (80-100℃, as high temperature promotes the dissolution of antioxidant components such as flavonoids and polysaccharides), cover and steep for 10-15 minutes. Gently shake the container once during this time to ensure the herbs are fully in contact with the water. After drinking, you can pour in boiling water again. One dose per day. It can be repeatedly brewed until the flavor becomes weak, then discard the dregs (generally 2-3 times). Do not drink overnight (as it is easy for bacteria to grow and the herbs to deteriorate). If you find the tea slightly bitter, you can add 1-2 rock sugar pieces or half a spoonful of honey to taste after the tea cools down to below 40℃ (high temperature will destroy the nutrients in honey and easily aggravate phlegm and dampness). Those who do not like sweetness can drink it directly; the original flavor can better exert the antioxidant effects of the herbs. One cycle is 14 days.

[0119] 2. Apply different herbal plasters to the Tian Tu, Tan Zhong, and bilateral Fei Shu acupoints respectively. Apply one plaster to each acupoint at a time, every 12-24 hours, for a 14-day cycle. Detailed implementation method:

[0120] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and further detailed. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The illustrative embodiments and descriptions of the present invention are only used to explain the present invention and are not intended to limit the present invention. All other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0121] Examples of the present invention: a combined system formulation for preventing and treating the harms of smoking

[0122] In response to the etiological and pathogenesis characteristics of the harm caused by smoking, A. The ingredients and dosage of the compound herbal tea taken orally are as follows: 400g of Adenophora stricta, 200g of Ophiopogon japonicus, 200g of dried lily scales, 100g of dried blueberries, 100g of Platycodon grandiflorus, 100g of dried double-petaled rose petals, 100g of dried jujubes (pitted), 100g of mulberry leaves, 100g of dried peppermint leaves, 50g of Astragalus membranaceus, and 50g of dried tangerine peel (aged for three years).

[0123] Preparation method of compound herbal tea substitute:

[0124] I. Pretreatment: ① Weigh out the four herbs (Radix Adenophorae), Radix Ophiopogonis, Radix Platycodi, and Radix Astragali according to the ingredient ratio, and place them separately in a vegetable washing basket. Rinse them quickly 1-2 times under running water to remove surface dirt, dust, and other residual impurities; ② After draining the water from the rinsed herbs, place them in a clean container, cover and wrap them with a damp cloth, and let them stand for 1-2 hours or soak them in warm water (30-40℃) for 10-15 minutes, then drain them. Place them separately on a cutting board and slice them into 2-3 mm thick diagonal slices; ③ Dry them for later use.

[0125] 2. Weigh the dried lily scales according to the ingredient ratio and rinse them quickly in running water 1-2 times to remove surface dust and residual impurities. After rinsing, take them out and soak them in warm water for 10 minutes. Then take them out and drain the water, remove any remaining brown stems, and dry them for later use.

[0126] 3. Weigh the dried blueberries according to the ingredient ratio and place them in a fine sieve. Rinse them quickly with running water for 10-20 seconds to remove surface dust, residual fruit pieces and impurities. Drain the water immediately after rinsing.

[0127] 4. Weigh the dried rose petals according to the ingredient ratio and place them in a fine sieve. Rinse them quickly with running water for 10-20 seconds to remove surface dust and impurities. After rinsing, immediately remove them, spread them flat on a clean gauze to drain the water, remove any remaining calyxes and stems, and dry them for later use.

[0128] 5. Weigh the dates according to the ingredient ratio and soak them in warm water for 5 minutes. Use a soft brush to gently scrub away any surface dust and residual impurities. Remove the date pits with a pitter and cut them into 0.5 cm thick slices. Dry them and set them aside.

[0129] 6. Weigh out the mulberry leaves according to the ingredient ratio, rinse them quickly in clean water 1-2 times to remove surface dust, insect eggs, and mud. Drain the water, remove the petioles and withered stems; cut into 0.5 cm wide thin strips, and dry them for later use.

[0130] 7. Weigh the dried mint leaves according to the ingredient ratio and place them in a fine sieve. Rinse them quickly with running water for 5-10 seconds to remove surface dust and residual stems. Drain the water, spread them evenly on a baking tray, and bake in an oven at 40℃ for 5 minutes, until the leaves are slightly dry and the aroma is more mellow. Let them cool and then seal them for later use.

[0131] 8. Weigh out the dried tangerine peel according to the ingredient ratio and soak it in warm water for 5-10 minutes. Use a clean, soft-bristled brush to gently scrub the surface of the tangerine peel and the white pith inside. Rinse it quickly with clean water again, drain the water, cut it into 0.5 cm wide strips, and dry it for later use.

[0132] II. Place all the pre-treated medicinal materials into a mixer and mix thoroughly. Then, measure 15 grams per bag and pack them into corn fiber tea bags or non-woven fabric tea bags. After heat sealing, the product is obtained.

[0133] B. The ingredients and dosage of Tian Tu acupoint plaster are as follows: 200g of Oroxylum indicum, 200g of Sterculia lychnophora, 100g of Eriobotrya japonica leaf, 100g of Platycodon grandiflorus, 80g of Trichosanthes kirilowii root, 50g of Arctium lappa fruit, and 40g of Chrysanthemum morifolium.

[0134] The preparation method is as follows: (1) Weigh each of the above-mentioned herbs according to the ingredient ratio, take half of each of the seven herbs, namely, Oroxylum indicum, Sterculia lychnophora, Eriobotrya japonica, Platycodon grandiflorus, Trichosanthes kirilowii, Arctium lappa and Chrysanthemum, add water and decoct twice, each time for 1.5 hours, combine the decoctions and concentrate them into a clear paste, the relative density of the clear paste is 1.25 (50-60℃);

[0135] (2) Take the remaining parts of the 7 herbs from step (1) and crush them into fine powder A with a mesh size of 200;

[0136] (3) In the paste of step (1), mix fine powder A from step (2) evenly, put it into a drying oven, dry it at 55-60℃, and discharge it when the moisture content reaches 5.8%. After cooling to room temperature, pulverize it into fine powder B of 200 mesh and weigh it 265 grams.

[0137] (4) Take 100 grams of honey, heat it to 119-122℃, with a water content of 5% and a density of about 1.40. When the surface is covered with large reddish-brown bubbles, add 61 grams of beeswax to melt it, filter it, and cool it to 58-82℃. Stir constantly and slowly add fine powder B. Stir constantly at 45-55℃, add 5.3 grams of azone, and stir constantly until it is a uniformly colored paste. Take 2 grams as a portion, spread it on the seepage-proof membrane in the seepage-proof ring in the middle of the adhesive non-woven base cloth, cover it with anti-stick paper, and package it to obtain the product.

[0138] C. The ingredients and dosage of the Tanzhong acupoint plaster are as follows: 180g of Salvia miltiorrhiza, 160g of Platycodon grandiflorus, 100g of Inula japonica, 90g of Glycyrrhiza uralensis, 80g of Paeonia lactiflora, 100g of Lilium brownii, 70g of Fritillaria thunbergii, 50g of Phragmites communis, 30g of Trichosanthes kirilowii, 30g of Citrus reticulata peel, and 30g of Poria cocos.

[0139] The preparation method is as follows: (1) Weigh each of the above-mentioned herbs according to the ingredient ratio, and take half of each of the 11 herbs, namely, Salvia miltiorrhiza, Platycodon grandiflorus, Inula japonica, Glycyrrhiza uralensis, Paeonia lactiflora, Lilium brownii, Fritillaria thunbergii, Phragmites communis, Trichosanthes kirilowii, Citrus reticulata, and Poria cocos. The rest is the same as in B. (1) above.

[0140] (2) Take the remaining parts of each of the 11 herbs from step (1) and grind them into fine powder A of 200 mesh;

[0141] (3) In the paste of step (1), mix fine powder A from step (2) evenly, put it into a drying oven, dry it at 55-60℃, and discharge it when the moisture content reaches 5.8%. After cooling to room temperature, pulverize it into fine powder B of 200 mesh and weigh it 318 grams.

[0142] (4) Take 120 grams of honey, heat it to 119-122℃, with a water content of 5% and a density of about 1.40. When the surface is covered with large reddish-brown bubbles, add 74 grams of beeswax to melt it, filter it, and cool it to 58-82℃. Stir constantly and slowly add fine powder B. Stir constantly at 45-55℃ and add 6.3 grams of azone. The rest is the same as in B. (4) above.

[0143] D. The ingredients and dosage of the Shuangfeishu acupoint plaster are as follows: Platycodon grandiflorus 200g, Tussilago farfara 100g, Peucedanum praeruptorum 100g, Lilium brownii 100g, Angelica sinensis 50g, Panax quinquefolius 30g, Astragalus membranaceus 30g, Citrus reticulata 30g.

[0144] The preparation method is as follows: (1) Weigh the herbs according to the ingredient ratio, and take half of each of the following herbs: Platycodon grandiflorus, Tussilago farfara, Peucedanum praeruptorum, Lilium brownii, Angelica sinensis, Panax quinquefolius, Astragalus membranaceus, Citrus reticulata, etc., and the rest are the same as in B. (1) above; and half of each of the following herbs: Fritillaria thunbergii, Phragmites communis, Trichosanthes kirilowii, Citrus reticulata, Poria cocos, etc., and the rest are the same as in B. (1) above.

[0145] (2) Take the remaining parts of the 8 herbs from step (1) and crush them into fine powder A of 200 mesh;

[0146] (3) In the paste of step (1), mix fine powder A from step (2) evenly, put it into a drying oven, dry it at 55-60℃, and discharge it when the moisture content reaches 5.8%. After cooling to room temperature, pulverize it into fine powder B of 200 mesh and weigh it 220 grams.

[0147] (4) Take 83 grams of honey, heat it to 119-122℃, with a water content of 5% and a density of about 1.40. When the surface is covered with large reddish-brown bubbles, add 51 grams of beeswax to melt it, filter it, and cool it to 58-82℃. Stir constantly and slowly add fine powder B. Stir constantly at 45-55℃ and add 4.4 grams of azone. The rest is the same as in B. (4) above.

[0148] Advantages of this invention: 1. Clinical observation of 200 cases in the treatment group and 200 cases in the control group (see the clinical report below for details) showed that after the course of treatment, the cure rate and total effective rate of the treatment group were significantly better than those of the control group. The treatment group experienced faster symptom improvement and showed significant effects in improving quality of life and physical condition. 2. Most of the Chinese medicinal herbs used in this invention's herbal tea are selected from a list of 106 medicinal and edible plants. It is healthy, natural, safe, effective, and has no toxic side effects, ensuring high safety. The taste is mild and palatable, with a light medicinal flavor, conforming to people's dietary habits and making it easy to use long-term. It is suitable for a wide range of people. It can be easily and conveniently prepared for various scenarios such as travel, fieldwork, office work, and commuting, making it more acceptable to the public and applicable to a wide range of situations. It solves the problems of traditional decoctions being cumbersome to prepare, inconvenient to carry, and limited in application scenarios. 3. Compared with single-use methods such as herbal teas, decoctions, or external plasters, this invention provides a systemic preparation combining an oral herbal tea with external plasters applied to the Tian Tu, Tan Zhong, and Bilateral Fei Shu acupoints. This system fully leverages the combined effects of drugs and meridians, neural and humoral regulation, bio-holographic and omnidirectional effects, amplification and diversity, producing a sympathetic and synergistic effect of mutual reception, synergy, complementary advantages, and coordination. It utilizes the systemic effect of the body's own five-organ integrated system for comprehensive and systematic regulation and intervention, relying on multiple sites, pathways, links, and effects. Therefore, it can comprehensively and significantly "alleviate existing symptoms" and "prevent damage," greatly improving the effectiveness of preventing and treating the harms of smoking.

[0149] Specific Examples and Clinical Reports

[0150] From January 2005 to December 2025, the combined system formulation for preventing and treating the harms of smoking provided by this invention was used to treat 200 outpatients with symptoms caused by the harms of smoking. A control group of 200 patients was also included to observe the efficacy. The results were good, and the report is as follows:

[0151] Clinical Data 1.1 General Information: The study subjects were male smokers aged 30-75 years, with a smoking frequency >20 cigarettes / day and a period >10 years. Eligible individuals were selected and randomly divided into a treatment group (n=200) and a control group (n=200) according to their order of visit. 1.2 Clinical Manifestations:

[0152] Distribution of clinical manifestations in the two groups of patients at admission

[0153]

[0154]

[0155] There were no statistically significant differences between the two groups of clinical data (P > 0.05), indicating they were comparable.

[0156] 2. Treatment methods

[0157] 2.1 Treatment group: Treatment with the combined system preparation of this invention alone: ​​① Oral compound tea substitute one packet per day, brewed repeatedly 3 times, 14 days as one cycle; ② External application of plaster to Tian Tu acupoint, Tan Zhong acupoint, and bilateral Fei Shu acupoints, one plaster per acupoint, one plaster per time, one plaster every 12-24 hours, 14 days as one course of treatment.

[0158] 2.2 Control Group: 1. Lung Yin Deficiency Type: 8 pills of commercially available Yangyin Qingfei Pills (concentrated pills) orally, 3 times a day; 2. Phlegm-Dampness Obstructing the Lungs Type: 9g of commercially available Er Chen Pills (water pills) orally, twice a day, taken with warm water; 3. Lung Heat and Phlegm Excess Type: 6g of commercially available Qingfei Yihuo Pills orally, twice a day; 4. Qi Deficiency and Blood Stasis Type: 5g of commercially available Yupingfeng Granules (Qi-tonifying) + Xuefu Zhuyu Capsules (Blood-activating), 3 times a day; 5. Mixed Type: The above medications were used in combination according to the specific symptoms; 14 days constituted one course of treatment.

[0159] 3. Efficacy Analysis

[0160] 3.1 Efficacy Criteria: Cured: All clinical symptoms have disappeared; Effective: Some clinical symptoms have disappeared or have been significantly reduced; Ineffective: All clinical symptoms have not been reduced or have worsened.

[0161] 3.2 Comparison of Efficacy: Table comparing the efficacy of one course of treatment between the two groups

[0162]

[0163] The results were statistically analyzed, and P < 0.01, indicating that there were significant differences in cure rate and total effective rate between the treatment group and the control group. The treatment group was significantly more effective than the control group, and no toxic side effects were found in any of the 200 cases in the treatment group.

[0164] 4. Typical Cases:

[0165] Example 1: Mr. Zhao, male, 59 years old, presented with a two-month history of dry cough with little phlegm, dry throat, and hoarseness, which worsened at night when lying flat and required clearing his throat upon waking. He had previously sought treatment at Danzi Town Health Center, receiving intravenous ceftriaxone sodium and dexamethasone injections, ultrasonic nebulization of dexamethasone and alpha-chymotrypsin, and oral pharyngitis tablets, but the dry cough persisted with poor treatment results. Inspection: Red tongue with little saliva and coating; dry and congested pharyngeal mucosa. Auscultation: Hoarse cough with a weak voice. Inquiry: The patient had smoked for 38 years, consuming 20 cigarettes daily. He experienced dry cough with little phlegm that was thick and difficult to expectorate, dry throat and mouth, which worsened at night. He also experienced night sweats, hot palms and soles, dry stools, a preference for cold drinks, and a tendency to sleep prone without being covered by blankets, indicating a Yin deficiency constitution. Palpation: Thready pulse. Diagnosis: Lung Yin Deficiency Type. Treatment with the combined system formulation of this invention alone: ​​① One packet of the compound herbal tea is taken orally daily, brewed repeatedly 3 times, for 14 days as one cycle; ② External application of plasters is applied to the Tian Tu, Tan Zhong, and bilateral Fei Shu acupoints, one plaster per acupoint, every 12-24 hours, for 14 days as one course of treatment. The patient is advised to quit smoking, avoid secondhand smoke, and avoid spicy and fried foods. On the 3rd day, a follow-up examination showed a reduction in the frequency of dry cough and a decrease in dry throat and hoarseness; after the first week, a follow-up examination showed that the dry cough and dry throat had disappeared, and there was no need to clear the throat in the morning; hoarseness was greatly relieved; in the second week, hoarseness recovered, and symptoms had basically disappeared; the patient was instructed to continue for another course of treatment to consolidate the therapeutic effect. One month later, a follow-up examination showed that all symptoms had healed; a six-month follow-up examination showed that smoking cessation was successful and symptoms had not recurred.

[0166] Example 2: Mr. Ding, male, 29 years old, presented with a 10-day history of sore throat, cough, thick yellow phlegm, and bitter taste in his mouth. He had previously sought treatment at a traditional Chinese medicine clinic and taken Qingfei Yihuo Wan (a traditional Chinese medicine formula) for a week, but the sore throat and cough persisted, and the treatment was ineffective. Inspection: Red face and eyes, swollen and red throat, grade I tonsil enlargement, red tongue with a yellow, greasy coating; Auscultation: Coarse cough, thick yellow phlegm that is difficult to expectorate; Inquiry: The patient has smoked for 8 years and recently, due to anxiety and insomnia, his smoking has increased dramatically to 2 boxes (40 cigarettes) per day. He also experiences cough with thick yellow phlegm, sore throat, bitter taste in his mouth, dry stools, and dark yellow urine; Palpation: Slippery and rapid pulse. Diagnosis: Lung heat with excessive phlegm type. Treatment with the combined system formulation of this invention alone: ​​① Oral administration of one packet of the compound herbal tea daily, brewed repeatedly three times, for 14 days as one cycle; ② External application of the plaster to the Tian Tu, Tan Zhong, and bilateral Fei Shu acupoints, one plaster per acupoint, applied every 12-24 hours, for 14 days as one course of treatment. The patient was instructed to immediately quit smoking and avoid tobacco, alcohol, barbecued foods, and other hot and dry foods. On the second day, a follow-up examination showed that the redness of the face and eyes had returned to normal, the sore throat had subsided, and the frequency of coughing had decreased. A follow-up examination after the first week showed that the yellow sputum had turned white and was easier to cough up, the bitter taste in the mouth had disappeared, and bowel movements had improved. A follow-up examination after the second week showed that the symptoms had basically disappeared; the patient was instructed to continue for another course of treatment to consolidate the therapeutic effect. A follow-up examination one month later showed that all symptoms had healed. A follow-up visit three months later showed that smoking cessation was successful and the symptoms had not recurred.

[0167] Finally, it should be noted that the specific embodiments described above enable those skilled in the art to gain a more comprehensive understanding of the present invention, but do not limit the present invention in any way. Therefore, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the present invention; and all technical solutions and improvements that do not depart from the spirit and technical essence of the present invention should be covered within the protection scope of this patent.

Claims

1. A combined system preparation for preventing and treating the harms of smoking and its preparation method, wherein the integrated combined system architecture is as follows: using different formulations of traditional Chinese medicine preparations to make a compound herbal tea for oral administration and a plaster for external application to the Tian Tu acupoint, Tan Zhong acupoint, and bilateral Fei Shu acupoints, forming an integrated combined system preparation for overall conditioning and prevention and treatment. Relying on the self-regulation mechanism of the human body's own five internal organs system, through comprehensive overall regulation and intervention, it achieves the prevention and treatment objectives of "preventing damage" and "relieving existing symptoms".

2. The combined system formulation according to claim 1, characterized in that, Different formulations of traditional Chinese medicine were used to prepare compound tea substitutes for oral administration and plasters for external application to the Tian Tu, Tan Zhong, and bilateral Fei Shu acupoints.

3. The combined system formulation according to claim 2, characterized in that, Targeting the etiological and pathological characteristics of the harms of smoking, preparations with different formulas were formulated, including oral compound herbal teas and external plasters for acupoints Tian Tu, Tan Zhong, and bilateral Fei Shu. The raw materials for these preparations are as follows: A. Oral compound herbal tea: 1-4g of Nan Sha Shen (Radix Adenophorae), 1-4g of Mai Dong (Radix Ophiopogonis), 1-4g of dried lily bulb scales, 1-4g of dried blueberries, 0.5-1g of Jie Geng (Radix Platycodi), 0.5-1g of dried double-petaled rose petals, 0.5-1g of dried jujube (pitted), 0.5-1g of frost-covered mulberry leaves, 0.5-1g of dried peppermint leaves, 0.1-0.5g of Huang Qi (Radix Astragali), and 0.1-0.5g of aged tangerine peel (aged for three years); B. Tian Tu acupoint: 0.5-2g of Mu Hu Die (Radix Oroxyli), 0.5-2g of Pang Da Hai (Semen Sterculiae), and 0.5-1g of loquat leaves. C. Plaster for Tanzhong acupoint: Salvia miltiorrhiza 0.5-2, Platycodon grandiflorus 0.5-2, Inula japonica 0.5-1, Glycyrrhiza uralensis 0.5-1, Paeonia lactiflora 0.5-1, Lilium brownii 0.5-1, Fritillaria thunbergii 0.5-1, Phragmites communis 0.1-0.5, Trichosanthes kirilowii 0.1-0.5, Citrus reticulata 0.1-0.5, Poria cocos 0.1-0.5; D. Plaster for bilateral Feishu acupoints: Platycodon grandiflorus 0.5-2, Tussilago farfara 0.5-1, Peucedanum praeruptorum 0.5-1, Lilium brownii 0.5-1, Angelica sinensis 0.1-0.5, Panax quinquefolius 0.1-0.5, Astragalus membranaceus 0.1-0.5, Citrus reticulata 0.1-0.

5.

4. The combined system formulation according to claim 3, characterized in that, In the compound herbal tea for oral administration, 1-4 parts by weight of *Adenophora stricta* can be replaced with an equal amount of *Adenophora stricta*, *Polygonatum odoratum*, or *Lycium barbarum* to achieve the same therapeutic effect; 0.5-1 part by weight of dried double-petaled rose petals can be replaced with an equal amount of *Salvia miltiorrhiza*, *Curcuma longa*, *Carthamus tinctorius*, *Prunus persica*, or *Rosa chinensis* to achieve the same therapeutic effect; and 0.5-1 part by weight of mulberry leaves can be replaced with an equal amount of chrysanthemum or honeysuckle to achieve the same therapeutic effect.

5. The combined system formulation according to claim 3, characterized in that, The A. oral compound herbal tea is prepared through the following steps: I. Pretreatment: ① Weigh out the four herbs (Radix Adenophorae), Radix Ophiopogonis, Radix Platycodi, and Radix Astragali according to the ingredient ratio, and place them separately in a vegetable washing basket. Rinse them quickly 1-2 times under running water to remove surface dirt, dust, and other residual impurities; ② After draining the rinsed herbs, place them in a clean container, cover with a damp cloth, and let stand for 1-2 hours or soak in warm water (30-40℃) for 10-15 minutes to soften them. After draining, place them on a cutting board and slice them into 2-3 mm thick diagonal slices; ③ Cut the sliced ​​herbs into thin slices...

1. Spread the pills evenly on a bamboo mat or gauze net and air dry them naturally in a well-ventilated, cool, and dry place.

2. Quickly rinse dried lily scales 1-2 times under running water to remove surface dust and impurities. Soak them in warm water for 10 minutes to soften, then drain and remove any remaining brown stems. Dry them completely.

3. Place dried blueberries in a fine sieve and quickly rinse them under running water for 10-20 seconds to remove surface dust, fruit scraps, and impurities. Drain and dry them completely.

4. Place dried rose petals in a fine sieve and quickly rinse them under running water for 10-20 seconds to remove surface dust and impurities. Immediately after soaking, remove the jujubes from the water and lay them flat on a clean gauze to drain. Remove any remaining calyxes and stems, and dry them for later use. Fifth, soak the jujubes in warm water for 5 minutes to soften the skin wrinkles. Gently brush away surface dust and impurities with a soft brush. Remove the pits with a pitter, slice into 0.5 cm thick slices, and dry them for later use. Sixth, quickly rinse the mulberry leaves 1-2 times in clean water to remove surface dust, insect eggs, and mud. Drain the water and remove the petioles and withered stems. If using whole mulberry leaves, cut them into 0.5 cm wide strips and dry them for later use. Seventh, place dried mint leaves in a fine sieve and quickly rinse them under running water for 5-10 minutes.

1. Rinse off surface dust and residual flower stems, wash and drain, then spread evenly on a baking tray, place in an oven at 40℃, bake for 5 minutes, let cool, and then seal for later use; 2. Soak dried tangerine peel in warm water for 5-10 minutes to soften it, while dissolving surface dust and residual impurities; use a clean, soft brush to gently scrub the surface of the tangerine peel and some of the white pith inside, rinse quickly with clean water again, drain, cut into 0.5 cm wide thin strips, and dry for later use; 3. Put all the pre-treated medicinal materials into a mixer and mix thoroughly, then measure 15g per bag and put them into corn fiber tea bags or non-woven fabric tea bags. Heat seal to obtain the product; 4. As stated in B.The Tian Tu acupoint external plaster is prepared by the following steps: (1) Boil half of the following seven herbs in water: Oroxylum indicum, Sterculia lychnophora, Eriobotrya japonica, Platycodon grandiflorus, Trichosanthes kirilowii, Arctium lappa, and Chrysanthemum morifolium; (2) Take the remaining portion of the seven herbs from step (1) and grind it into fine powder A; (3) Mix the clear paste from step (1) with fine powder A from step (2), dry it, and then grind it into a paste-like fine powder B; (4) Heat an appropriate amount of honey until it is covered with large, reddish-brown bubbles, and add an appropriate amount of honey. The beeswax is melted, and then the fine powder B from step (3) and an appropriate amount of transdermal agent are added gradually in batches while stirring. After mixing evenly, a paste is made. C. The external plaster for the Tanzhong acupoint is prepared by the following steps: (1) Add water to decoct half of the following 11 herbs: Salvia miltiorrhiza, Platycodon grandiflorus, Inula japonica, Glycyrrhiza uralensis, Paeonia lactiflora, Lilium brownii, Fritillaria thunbergii, Phragmites communis, Trichosanthes kirilowii, Citrus reticulata, and Poria cocos; (2) Take the remaining part of the 11 herbs from step (1) and crush it into fine powder A; (3) Combine the clear paste from step (1) with In step (2), fine powder A is mixed, dried, and then pulverized into fine powder B acceptable for ointment; (4) Take an appropriate amount of honey and heat it until the surface is covered with large reddish-brown bubbles, add an appropriate amount of beeswax to melt, then add fine powder B from step (3) and an appropriate amount of transdermal agent in batches, stirring while adding, and mix evenly to make an ointment; D. External plaster for the bilateral lung acupoints is prepared by the following steps: (1) Add water to decoct Platycodon grandiflorus, Tussilago farfara, Peucedanum praeruptorum, Lilium brownii, Angelica sinensis, Panax quinquefolius, Astragalus membranaceus, and Agrimonia pilosa. (1) Take half the amount of each of the eight herbs from step (1); (2) Take the remaining portion of each of the eight herbs from step (1) and grind it into fine powder A; (3) Mix the clear paste from step (1) with the fine powder A from step (2), dry it, and then grind it into a fine powder B acceptable for ointment; (4) Take an appropriate amount of honey, heat it until the surface is covered with large, reddish-brown bubbles, add an appropriate amount of beeswax to melt it, then add the fine powder B from step (3) and an appropriate amount of transdermal agent gradually in batches, stirring while adding, and mix evenly to make an ointment.

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