Moisturizing, whitening and anti-chap soap and preparation method thereof

Abstract

The invention discloses moisturizing, whitening and chap-preventing soap and a preparation method thereof, and belongs to the technical field of daily chemicals. The soap provided by the invention contains 5-25 parts of enzymolysis trichosanthes kirilowii pulp, 0.5-2 parts of a microemulsion andrographolide composition and the like. The problems that active ingredients are difficult to release and easy to inactivate are solved through the composite enzymolysis and nanometer micro-emulsification technology, the L * value is increased by more than or equal to 4.5, the water content is increased by more than or equal to 48%, the TEWL value of percutaneous water loss is obviously reduced, the IL-6 is reduced by more than or equal to 58%, the synergy index is 1.76, and it is predicted that the stability is good within 24 months, and skin irritation is avoided.

Description

A moisturizing, whitening, and anti-chapping soap and its preparation method Technical Field

[0001] This invention relates to the field of daily chemical products technology, specifically to a moisturizing, whitening, and anti-chapping soap and its preparation method; more particularly, to a moisturizing, whitening, and anti-chapping soap and its preparation method that activates natural ingredients through a specific pretreatment technology and achieves synergistic effects. Background Technology

[0002] As a basic cleaning product, soap is evolving from a single cleaning product to an integrated "cleansing-care-repairing" product. There is an urgent market demand for soaps with natural ingredients that also offer multiple benefits such as long-lasting moisturizing, brightening skin tone, strengthening the skin barrier, and soothing sensitive skin.

[0003] Trichosanthes kirilowii pulp is rich in polysaccharides, saponins and other active substances, and has potential moisturizing and repairing value; andrographolide is a known anti-inflammatory ingredient. However, applying the two directly to soap faces inherent technical bottlenecks: (1) The plant cell structure of Trichosanthes kirilowii pulp makes it difficult for its active ingredients to be released quickly and act on the skin during the washing process, resulting in low bioavailability; (2) Andrographolide has extremely poor water solubility, making it difficult to disperse in the alkaline aqueous phase system of soap base and having poor chemical stability, resulting in a serious mismatch between the amount added as labeled and the actual efficacy; (3) Existing technologies are mostly simple compounding of multiple plant extracts, lacking research on improving the efficiency of single ingredients through deep processing technology, and even less so scientific verification and product design on whether there is a synergistic effect between compounded ingredients.

[0004] Therefore, the core challenge in developing the next generation of high-performance functional soaps is to overcome the aforementioned application barriers through innovative pretreatment processes and to design ingredient combinations that can produce synergistic effects. Summary of the Invention

[0005] To address the above technical problems, this invention provides a moisturizing, whitening, and anti-chapping soap containing enzymatically hydrolyzed Trichosanthes kirilowii pulp and microemulsified andrographolide, along with its preparation method. This invention provides a soap that significantly improves the release rate of active ingredients from Trichosanthes kirilowii while simultaneously improving the water dispersibility, stability, and transdermal permeability of andrographolide, achieving multiple synergistic effects of moisturizing, whitening, anti-chapping, and anti-inflammatory properties. Through compound enzymatic hydrolysis and nano-microemulsification technology, the problems of difficult release and easy inactivation of active ingredients are solved, achieving an L* value increase of ≥4.5, a moisture increase of ≥48%, a significant reduction in transdermal water loss (TEWL) value, a IL-6 decrease of ≥58%, a synergistic index of 1.76, good stability predicted for 24 months, and no skin irritation.

[0006] The first objective of this invention is to provide a moisturizing, whitening, and anti-chapping soap, comprising the following components by weight: 5-25 parts of enzymatically hydrolyzed Trichosanthes kirilowii pulp; 0.5-2 parts of microemulsified andrographolide composition; 50-70 parts of oil; 6-15 parts of moisturizer; 10-15 parts of edible beeswax; 0-3 parts of additives; and 20-25 parts of deionized water.

[0007] In some embodiments of the present invention, the microemulsion andrographolide composition comprises a transparent nanoemulsion of andrographolide 0.5-2wt%, lecithin 3-5wt%, sodium hyaluronate 2-4wt%, glycerol 1-2wt%, and the balance water, with an average particle size of 35-50 nm.

[0008] In some embodiments of the present invention, the microemulsion andrographolide composition is prepared by the following method: using lecithin and sodium hyaluronate as membrane materials, and combining andrographolide, a transparent nanoemulsion is prepared under high-pressure homogenization-ultrasound conditions, which is the microemulsion andrographolide composition. The present invention utilizes the addition of the microemulsion andrographolide composition to achieve highly effective anti-inflammatory, soothing, and synergistic anti-chapping effects.

[0009] In some embodiments of the present invention, the mass ratio of andrographolide, lecithin and sodium hyaluronate is 1:(4-6):(2-4); the conditions for high-pressure homogenization-ultrasound combined use are as follows: high-pressure homogenization: pressure is 80-120 MPa, 2-4 cycles; ultrasonic treatment: carried out under ice bath conditions, power is 300-500 W, time is 10-20 minutes.

[0010] In some embodiments of the present invention, the enzymatically hydrolyzed Trichosanthes kirilowii pulp is prepared by the following method: (a) fresh Trichosanthes kirilowii pulp is crushed and water is added to form a homogenate, wherein the weight of water is 1-3 times the weight of Trichosanthes kirilowii pulp; (b) 0.5-2.0 wt% pectinase and 0.2-1.0 wt% cellulase are added, and the mixture is enzymatically hydrolyzed at 45-55 °C and pH 4.5-5.5 for 30-120 minutes; (c) the enzyme is inactivated at 85-90 °C for 10 minutes, and the mixture is filtered to obtain the enzymatically hydrolyzed Trichosanthes kirilowii pulp.

[0011] In some embodiments of the present invention, the oils include trichosanthes seed oil, coconut oil, olive oil, and palm oil; the moisturizer is selected from at least two of fresh cucumber pulp, fresh lemon juice, glycerin, and honey.

[0012] In this invention, enzymatic hydrolysis of Trichosanthes kirilowii juice is used to achieve long-lasting moisturizing, skin barrier repair, and skin whitening effects.

[0013] In some embodiments of the present invention, the adjuvants include one or more of antioxidants, metal ion chelators, preservatives, and fragrances.

[0014] In some embodiments of the present invention, the antioxidants include, but are not limited to, one or more of vitamin E (tocopherol), tert-butylhydroquinone (BHT), and tea polyphenols; the metal ion chelating agents include, but are not limited to, disodium ethylenediaminetetraacetate (EDTA-2Na); the preservatives include, but are not limited to, one or more of phenoxyethanol, potassium sorbate, and sodium benzoate; the fragrances include, but are not limited to, natural plant essential oils and / or food-grade fragrances; the natural plant essential oils include lavender essential oil and / or tea tree essential oil.

[0015] The second objective of this invention is to provide a method for preparing the aforementioned moisturizing, whitening, and anti-chapping soap, comprising the following steps: providing an enzymatically hydrolyzed trichosanthes fruit pulp and a microemulsified andrographolide composition; mixing and heating the oils to obtain an oil phase; adding an alkaline solution to the oil phase and stirring until the viscosity reaches 1000-4000 mPa·s; then adding the enzymatically hydrolyzed trichosanthes fruit pulp, the microemulsified andrographolide composition, a humectant, and an auxiliary agent, homogenizing, and then molding; and keeping warm, demolding, and curing to obtain the aforementioned moisturizing, whitening, and anti-chapping soap.

[0016] In some embodiments of the present invention, the temperature of the mixing and heating is 40-45 °C; the alkaline solution includes an alkali metal hydroxide solution; preferably a sodium hydroxide solution and / or a potassium hydroxide solution; for the solid soap of the present invention, sodium hydroxide is mainly used.

[0017] The heat preservation temperature is 35-40 ℃, and the time is 24-48 hours; the curing time is 4-6 weeks.

[0018] The beneficial effects of this invention are as follows: 1. This invention uses a compound enzymatic hydrolysis technology to break down the plant cell walls of Trichosanthes kirilowii pulp, allowing the full release of its internal moisturizing polysaccharides, restorative amino acids, and other active ingredients, thus solving the problem of low bioavailability of natural plant components. Simultaneously, through a nano-microemulsification technology combining high-pressure homogenization and ultrasound, andrographolide is encapsulated in a lecithin-sodium hyaluronate composite membrane, forming a stable nanocarrier with an average particle size of 35-50 nm, effectively overcoming the application challenges of poor water dispersibility and high chemical instability in soap bases.

[0019] 2. This invention, through the combination of the two pretreatment technologies mentioned above, not only maximizes the release of the efficacy of each active ingredient, but more importantly, the moist repair environment created by enzymatic hydrolysis of Trichosanthes kirilowii juice and the deep anti-inflammatory effect of microemulsified andrographolide produce a significant synergistic effect (synergistic index 1.76). This synergy manifests as follows: moisturizing strengthens the skin barrier function, providing a basis for the action of anti-inflammatory ingredients; anti-inflammatory and soothing properties break the inflammation cycle caused by dryness, fundamentally improving the efficiency and durability of moisturizing and repair, thereby achieving a comprehensive effect of moisturizing, whitening, and preventing chapping, where '1+1>2'.

[0020] 3. Compared with the blank soap, the soap of this invention achieves the following within 4 weeks: 1) Skin brightness L* value increased by ≥4.5; 2) Stratum corneum moisture content increased by ≥48%; 3) TEWL decreased by ≥34%; 4) Inflammatory factor IL-6 decreased by ≥58%; 5) Synergistic index Q=1.76 (>1.15), indicating a significant synergistic effect; 6) Rated as "non-irritating" through acute skin irritation test (OECD TG 404); 7) Accelerated test (40... o After 24 months (C / 75%RH), the retention rate of active ingredients is ≥95%, and the particle size change is ≤10%. Attached Figure Description

[0021] To make the content of this invention easier to understand, the invention will be further described in detail below with reference to specific embodiments and accompanying drawings. Figure 1 shows the appearance and foam of the soap from Example 1 of this invention; Figure 2 shows a comparison photograph of hand skin before and after 4 weeks of use; Figure 3 is a bar chart showing the increase in L* value for each group; Figure 4 is a comparison chart of stratum corneum moisture content and TEWL value for each group; Figure 5 is a microscopic image (×100x) of chapped skin on the hands; Figure 6 is a bar chart showing the percentage decrease in IL-6 for each group; Figure 7 is a comparison chart of the content of active ingredients in Trichosanthes kirilowii before and after enzymatic hydrolysis; Figure 8 is a particle size distribution diagram of the microemulsified andrographolide of this invention. Detailed Implementation

[0022] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, so that those skilled in the art can better understand and implement the present invention. However, the embodiments described are not intended to limit the present invention.

[0023] Example 1: This example provides a moisturizing, whitening and anti-chapping soap containing enzymatically hydrolyzed Trichosanthes kirilowii pulp and microemulsified andrographolide, as follows: (1) Enzymatically hydrolyzed Trichosanthes kirilowii pulp: Take 100 g of fresh Trichosanthes kirilowii pulp, crush it, add 1.2 g of pectinase (Pectinanse from Aspergillus aculeatus, Sigma-Aldrich, E6287) and 0.6 g of cellulase (Cellulase from Trichoderma reesei, TCI, C0057), adjust the pH to 5.0, hydrolyze at 50 ℃ for 90 min, inactivate the enzyme at 85 ℃ for 10 min, and filter to obtain the product.

[0024] (2) Microemulsion andrographolide composition: 1.0 g of andrographolide, 4.0 g of lecithin, 3.0 g of sodium hyaluronate, 1.0 g of glycerin, and water to make up to 100 g. The mixture was sonicated in an ice bath for 15 min to obtain a 45 nm transparent emulsion.

[0025] (3) Soap preparation: a. Formula (total weight 100 parts): 20 parts enzymatic hydrolyzed trichosanthes pulp, 10 parts trichosanthes seed oil, 2 parts microemulsion composition, 30 parts coconut oil, 5 parts olive oil, 12 parts palm oil, 8 parts cucumber pulp, 4 parts lemon juice, 3 parts glycerin, 2 parts honey, 12 parts beeswax, 22 parts deionized water, 0.1 parts EDTA-2Na, 0.1 parts vitamin E, 0.3 parts phenoxyethanol.

[0026] b. Process: S1 Mix coconut oil, olive oil, palm oil, and trichosanthes seed oil and heat to 45 ℃ to obtain the oil phase; S2 Prepare the lye solution: Dissolve sodium hydroxide (calculated based on a lye-to-oil mass ratio of 0.135:1) in a portion of deionized water to prepare a 25wt% solution, and cool to 45 ℃; S3 Slowly add the lye solution obtained in step S2 to the oil phase, stirring until the viscosity reaches 2000 mPa·s; S4 Add enzymatically hydrolyzed trichosanthes pulp, microemulsified andrographolide composition, cucumber pulp, lemon juice, glycerin, honey, and auxiliary agents (EDTA-2Na, vitamin E, phenoxyethanol, lavender essential oil) sequentially, homogenize, and pour into a mold; S5 Keep at 40 ℃ for 48 hours, demold, and cure for 5 weeks to obtain the moisturizing, whitening, and anti-chapping soap. The curing environment temperature is 25 ℃, the relative humidity is 60%, and it should be protected from light and ventilated.

[0027] Comparative Examples 1-4 and Blank Control: The corresponding components were replaced / omitted according to the scheme in Table 1, and the rest was the same as in Example 1.

[0028] Table 1 Comparison of experimental design groups Note: Groups B, D, E, and F are prepared using the same basic formula and process as Group A, with only the corresponding components or forms changed according to the table above.

[0029] The efficacy test was conducted to systematically verify the whitening, moisturizing, barrier repair, and anti-inflammatory and soothing effects of the soap of this invention, and to quantitatively evaluate the synergistic effect between "enzymatic hydrolysis of Trichosanthes kirilowii juice" and "microemulsified andrographolide". The following series of human efficacy evaluation experiments were designed and carried out for the six groups of samples (AF group).

[0030] 1. Whitening (1) Test objective: To evaluate the effect of soap on improving skin brightness and to analyze the contribution of each functional component and its processing technology.

[0031] (2) Experimental method: Subjects: 60 healthy female volunteers aged 25-50 (Fitzpatrick skin type III-IV) were recruited and randomly divided into 6 groups of 10 people each, and used AF group soap respectively.

[0032] (3) Testing Procedure: Subjects used the designated soap to cleanse their faces every morning and evening for 4 consecutive weeks. Before use (day 0), and at week 2 and week 4 after use, the skin brightness value (L* value) of a fixed cheek area was measured using a professional skin colorimeter (model: CM-700d, Konica Minolta) under constant environmental conditions (temperature 22±1 ℃, humidity 50±5%). Each area was measured three times and the average value was taken. The variation of L* value of each group of volunteers within 4 weeks was calculated, and paired t-tests within groups and one-way ANOVA between groups were performed. The significance level was set at p<0.05.

[0033] (4) Experimental results: Table 2 Results of synergistic whitening effect test (skin brightness value (L* value)) Note: p<0.01 indicates extremely significant difference, ***; p<0.05 indicates significant difference, **; p>0.05 indicates no significant difference, *.

[0034] (5) Results Analysis: The data trend shows that the increase in the * value of group A is not only higher than that of each single component group, but also significantly higher than that of the compound control group (groups D and E) without the corresponding pretreatment process. This result indicates that the trichosanthes kirilowii treated with compound enzymatic hydrolysis and andrographolide treated with microemulsion show a synergistic trend of improving skin brightness in the soap system of this invention, and its whitening effect is not a simple superposition of the effects of each single component.

[0035] 2. Moisturizing and Barrier Repair (1) Test Objective: To evaluate the efficacy of soap in increasing skin hydration and repairing the skin's physical barrier.

[0036] (2) Experimental method: Subjects and grouping: Same as Experiment 1.

[0037] (3) Testing procedure: Before use and 4 weeks after use, the stratum corneum moisture content (AU) of the same cheek area was measured using a skin moisture meter (Cornemeter® CM825), and the transepidermal water loss (TEWL value, g·h⁻) of the same area was measured using a transepidermal water loss meter (Tewameter®™ 300). 1 ·m⁻ 2 Each indicator was measured three times and the average value was taken. Data analysis: The percentage increase in moisture content and the percentage decrease in TEWL value were calculated, and inter-group comparisons were performed.

[0038] (4) Experimental results: Table 3 Results of synergistic moisturizing and barrier repair effect test (stratum corneum moisture content (AU) and transepidermal water loss (TEWL) value) Note: The differences between group A and groups B, C, D, E, and F in both indicators were statistically significant, with p < 0.05 indicating a significant difference.

[0039] (5) Results Analysis: The results showed that the soap using enzymatic hydrolysis of Trichosanthes kirilowii pulp combined with microemulsified andrographolide (Group A) performed best in both increasing the moisture content of the stratum corneum and reducing transepidermal water loss (TEWL), and the differences compared with the other groups were statistically significant (p<0.05). Compared with the control group containing only a single component or without the corresponding pretreatment process, Group A achieved more significant improvements in both indicators, indicating that the combined enzymatic hydrolysis and microemulsification treatment can significantly improve the moisturizing and barrier repair efficiency of active ingredients. In particular, in terms of reducing TEWL, the improvement in Group A was significantly better than that in the control group without microemulsification treatment, indicating that this pretreatment process helps to enhance the skin barrier function. The above results indicate that Trichosanthes kirilowii and andrographolide, after specific pretreatment, exhibit a synergistic effect in improving skin moisturizing and barrier function in the system of this invention.

[0040] 3. Anti-inflammatory and soothing (1) Test objective: To quantitatively evaluate the anti-inflammatory efficacy of the soap and to calculate the synergistic effect index between "enzymatic hydrolysis of Trichosanthes kirilowii" and "microemulsified andrographolide".

[0041] (2) Experimental method: Subjects: From the volunteers in Experiment 1, those diagnosed with mild sensitive skin by lactic acid stinging test were selected in each group (n=6 per group).

[0042] (3) Testing procedure: After 4 weeks of use, a non-invasive skin sampling patch (such as Sebutape®) was applied to healthy skin on the inner forearm for 1 hour to collect tissue fluid from the skin surface. The content of the inflammatory factor interleukin-6 (IL-6) in the sample was quantitatively detected using a high-sensitivity ELISA kit.

[0043] Synergistic effect calculation: A simplified evaluation was performed using the Chou-Talalay combination index method. The approximate value of the synergistic index (CI), Q, was calculated using the formula: Q = Eab / (Ea + Eb - Ea × Eb), where Ea and Eb represent the IL-6 reduction rates of group B (deficient in Trichosanthes kirilowii, representing the single effect of "microemulsified andrographolide") and group C (deficient in Andrographis paniculata, representing the single effect of "enzymatically hydrolyzed Trichosanthes kirilowii"), respectively, and Eab represents the IL-6 reduction rate of group A. Generally, Q > 1.15 indicates synergy, Q between 0.85 and 1.15 indicates additive effects, and Q < 0.85 indicates antagonism.

[0044] (4) Experimental Results Table 4 Synergistic Anti-inflammatory and Soothing Effect Test (Inflammatory Factor (IL-6 Value) Results) Note: The decrease rate of group A differed significantly from that of groups B, C, D, and E (p < 0.01).

[0045] Synergy index calculation Q=0.583 / (0.205+0.158-0.205×0.158)=0.583 / (0.363-0.032)≈1.76; (5) Results analysis The experimental results showed that the soap (Group A) using enzymatic hydrolysis of Trichosanthes kirilowii pulp and microemulsified andrographolide had a significantly better inhibitory effect on the inflammatory factor IL-6 than the control group containing only one single component or without the corresponding pretreatment process (p<0.01). The synergy index calculated by the combination index method was Q≈1.76, which was significantly higher than the synergy judgment threshold, indicating that the two active ingredients with specific pretreatment produced a significant synergistic anti-inflammatory and soothing effect in the system of the present invention, rather than a simple additive effect.

[0046] 4. Crack Repair (1) Test objective: To verify the repair effect of soap on skin that has cracked.

[0047] (2) Experimental method: Subjects: Another 30 volunteers with mild to moderate hand chapped skin in winter (clinical score 2-3) were recruited and randomly divided into 3 groups: Group A (this invention), Group C (without Andrographis paniculata), and Group F (basic soap), with 10 people in each group.

[0048] (3) Testing Procedure: Wash hands twice daily with the designated soap, and apply a uniform basic moisturizing cream to the affected area 30 minutes after washing. Follow-up was conducted at weeks 0, 2, 4, and 6. The severity, area, and dryness of the fissures were scored using a visual assessment scale. At weeks 0 and 6, 100x magnification images of fixed locations were taken using a dermoscope (Dino-Lite Premier), and the pixel area ratio of the fissure area was calculated using image analysis software.

[0049] (4) Experimental Results Table 5 Clinical Improvement Test Results for Anti-chapped Skin (5) Results Analysis: Group A was significantly better than Groups C and F in all indicators. This result directly reflects the clinical value of the synergistic effect: based on the excellent moisturizing and physical repair provided by the Trichosanthes kirilowii components, the addition of andrographolide, through its powerful synergistic anti-inflammatory effect, can more quickly and thoroughly relieve the redness, swelling, pain, and itching symptoms associated with chapped skin, thereby accelerating the healing process and improving the quality of repair. This demonstrates the outstanding advantages of the combination of the present invention from a practical application perspective.

[0050] Accelerated stability and safety verification test: The sample from Example 1 was sealed in an aluminum foil bag and placed in a constant temperature incubator at 40±2 ℃ and RH 75±5% for 3 months. Samples were taken at 0, 30, 60, and 90 days, and the content of andrographolide was determined by HPLC, and the particle size was determined by DLS. The results are shown in Table 6.

[0051] Table 6 Results after 90 days of accelerated recovery Conclusion: All changes were less than the judgment threshold, indicating that the 24-month shelf life is acceptable.

[0052] The embodiments described above are merely preferred embodiments for fully illustrating the present invention, and the scope of protection of the present invention is not limited thereto. Equivalent substitutions or modifications made by those skilled in the art based on the present invention are all within the scope of protection of the present invention.

Claims

1. A moisturizing, whitening, and anti-chapping soap, characterized in that, By weight, it comprises the following components: 5-25 parts of enzymatically hydrolyzed Trichosanthes kirilowii pulp; 0.5-2 parts of microemulsified andrographolide composition; 50-70 parts of oil; 6-15 parts of humectant; 10-15 parts of edible beeswax; and 0-3 parts of adjuvants. 20-25 parts deionized water.

2. The moisturizing, whitening, and anti-chapping soap as described in claim 1, characterized in that, The microemulsion andrographolide composition comprises a transparent nanoemulsion of andrographolide 0.5-2wt%, lecithin 3-5wt%, sodium hyaluronate 2-4wt%, glycerol 1-2wt%, and the balance water, with an average particle size of 35-50 nm.

3. The moisturizing, whitening, and anti-chapping soap as described in claim 1 or 2, characterized in that, The microemulsion andrographolide composition was prepared by the following method: using lecithin and sodium hyaluronate as membrane materials, and combining andrographolide, a transparent nanoemulsion was prepared under high pressure homogenization-ultrasound conditions, which is the microemulsion andrographolide composition.

4. The moisturizing, whitening, and anti-chapping soap as described in claim 3, characterized in that, The mass ratio of andrographolide, lecithin and sodium hyaluronate is 1:(4-6):(2-4); High-pressure homogenization-ultrasound combined treatment conditions: High-pressure homogenization: pressure 80-120MPa, 2-4 cycles; Ultrasound treatment: carried out under ice bath conditions, power 300-500W, time 10-20 minutes.

5. The moisturizing, whitening, and anti-chapping soap as described in claim 1, characterized in that, The enzymatically hydrolyzed Trichosanthes kirilowii pulp is prepared by the following method: (a) fresh Trichosanthes kirilowii pulp is crushed and water is added to form a homogenate; wherein the weight of water is 1-3 times the weight of Trichosanthes kirilowii pulp; (b) pectinase and cellulase are added, and enzymatic hydrolysis is carried out at 45-55 ℃ and pH 4.5-5.5 for 30-120 minutes; (c) the enzymes are inactivated at 85-90 ℃ and filtered to obtain the enzymatically hydrolyzed Trichosanthes kirilowii pulp.

6. The moisturizing, whitening, and anti-chapping soap as described in claim 1, characterized in that, The oils include trichosanthes seed oil, coconut oil, olive oil, and palm oil; the moisturizers are selected from at least two of fresh cucumber pulp, fresh lemon juice, glycerin, and honey.

7. The moisturizing, whitening, and anti-chapping soap as described in claim 1, characterized in that, The additives include one or more of antioxidants, metal ion chelating agents, preservatives, and fragrances.

8. The moisturizing, whitening, and anti-chapping soap as described in claim 7, characterized in that, The antioxidants include one or more of vitamin E, tert-butylhydroquinone, and tea polyphenols; the metal ion chelating agent includes disodium ethylenediaminetetraacetate; the preservatives include one or more of phenoxyethanol, potassium sorbate, and sodium benzoate; and the flavorings include natural plant essential oils and / or food-grade flavorings.

9. The preparation method of the moisturizing, whitening, and anti-chapping soap according to any one of claims 1 to 8, characterized in that, Includes the following steps: A composition of enzymatically hydrolyzed Trichosanthes kirilowii pulp and microemulsified andrographolide is provided; the oil is mixed and heated to obtain an oil phase; an alkaline solution is added to the oil phase and stirred until the viscosity is 1000-4000 mPa·s; then the enzymatically hydrolyzed Trichosanthes kirilowii pulp, the microemulsified andrographolide composition, a humectant and an auxiliary agent are added, and after homogenization, the mixture is poured into a mold; The soap is then kept warm, unmolded, and cured to obtain the moisturizing, whitening, and anti-chapping soap.

10. The preparation method according to claim 9, characterized in that, The temperature for mixing and heating is 40-45 ℃; the alkaline solution includes an alkali metal hydroxide solution; the holding temperature is 35-40 ℃ for 24-48 hours; and the aging time is 4-6 weeks.

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