Total nutrient compound based on nutrition and metabolism coordinated regulation and preparation method thereof

Abstract

The invention discloses a total nutrient compound based on nutrition and metabolism coordinated regulation and a preparation method thereof. The compound comprises a three-level function coordinated system, namely a nutrition foundation system, a metabolism regulation core system and a metabolism environment guarantee system. The nutrition foundation system comprises a slow-release energy supply unit and a basic nutrition enhancement and anti-oxidation unit; the metabolism regulation core system comprises a glycolipid metabolism regulation unit and an intestinal micro-ecological regulation unit; the glycolipid metabolism regulation unit consists of organic trivalent chromium, organic magnesium and organic selenium; the intestinal micro-ecological regulation unit is composed of a psyllium husk extract and micro-capsule embedded composite probiotics; the metabolic environment guarantee system comprises a nerve-endocrine homeostasis unit and a blood vessel health guarantee unit; the nerve-endocrine homeostasis unit consists of a South African drunken solanum extract, L-theanine and gamma-aminobutyric acid; the blood vessel health guarantee unit consists of nattokinase, phytosterol ester, a grape seed extract and a deep sea fish oil extract.

Description

Technical Field

[0001] This invention relates to the field of food technology, and more specifically to a complete nutritional complex based on the synergistic regulation of nutrition and metabolism and its preparation method. Background Technology

[0002] Nutritional supply is the material basis for human metabolism, and the normal operation of the metabolic network is the core guarantee for life activities. The two follow the natural physiological law of the human body: "nutrition lays the foundation and metabolism empowers". The human body obtains macronutrients and micronutrients by ingesting specific nutrients, providing raw materials for metabolic activities such as cell proliferation, energy conversion, and signal transduction. The efficient operation of the metabolic system can convert nutrients into energy and bioactive substances required for life activities, forming a mutually supportive and mutually promoting physiological closed loop.

[0003] In modern society, people generally face two fundamental health problems due to factors such as unbalanced diets, irregular work and rest schedules, and excessive stress: First, insufficient intake or low absorption efficiency of basic nutrients, such as a lack of key nutrients like vitamin D, high-quality protein, and chelated minerals, leads to a weak material basis for metabolic activities, violating the physiological law that "nutrients provide raw materials for metabolism"; Second, disordered core metabolic processes such as glucose and lipid metabolism, intestinal metabolism, and neuroendocrine metabolism disrupt the body's metabolic homeostasis, forming a vicious cycle of "nutritional imbalance-metabolic disorder," which in turn leads to problems such as overweight, sub-health, and abnormal vascular function.

[0004] Many existing nutritional supplements or functional foods suffer from technical deficiencies and fail to fully integrate the core logic of "material carrier + physiological laws": some products focus only on the supply of basic nutrients, lacking targeted metabolic regulation design, failing to address the core issue of metabolic network disorder, and violating the physiological law of "synergistic nutrition and metabolism"; some products only intervene in a single metabolic link (such as glucose metabolism), failing to build a systematic nutritional and metabolic synergistic regulation system, and failing to form a complete logic of "material supply - law adaptation"; at the same time, the formulation ratios of most products lack clear molecular mechanism support, the synergistic effect has not been scientifically verified, and there are problems with non-standard descriptions, easily crossing the red line of medical terminology, and failing to clarify the specific material carriers corresponding to each function and the physiological laws followed.

[0005] Therefore, the development of a complete nutritional complex that focuses on "solving fundamental problems of nutrition and metabolism," relies on specific combinations of nutrients, follows the physiological laws of the human body, and combines precise nutritional supply and systematic metabolic regulation with a scientifically formulated formula has become an urgent need in the field of functional foods. Summary of the Invention

[0006] Studies have shown a clear hierarchical dependency between nutrient intake, core metabolic processes, and overall homeostasis. As stated in the authoritative physiology text *Guyton and Hall Textbook of Medical Physiology*, "Metabolism is the sum of all chemical reactions in the body, but these reactions depend on the availability of substrates (nutrition) and occur within a tightly regulated internal environment (homeostasis)." Based on this, this invention proposes a three-tiered synergistic design concept of "nutritional foundation → metabolic regulation → environmental protection," and a complete nutritional complex and its preparation method based on this three-tiered functional synergistic system of "nutritional foundation system, metabolic regulation core system, and metabolic environmental protection system." Each system is composed of clearly defined nutrients and active ingredients, strictly following the natural physiological laws of the human body: "nutritional foundation → metabolic regulation → environmental protection." Through precise raw material selection, specific ratio design, and a clear synergistic mechanism, it achieves comprehensive and efficient supply of basic nutrition and systematic optimization of the metabolic network, addressing the shortcomings of existing technologies such as the disconnect between nutrition and metabolic regulation, unclear synergistic effects, and insufficient integration of material carriers and physiological laws.

[0007] According to one aspect of the present invention, a complete nutritional complex based on synergistic regulation of nutrition and metabolism is provided, comprising: a three-level functional synergistic system of a nutritional foundation system, a metabolic regulation core system, and a metabolic environment protection system; The nutritional foundation system includes a slow-release energy supply unit and a basic nutritional fortification and antioxidant unit. The slow-release energy supply unit consists of oat β-glucan extract, quinoa polysaccharide extract, and a mixture of small molecule peptides, wherein the small molecule peptide mixture is whey protein peptide extract and soy protein isolate extract. The basic nutritional fortification and antioxidant unit consists of a chelated / organic mineral complex and a vitamin complex. The core metabolic regulation system includes a glucose and lipid metabolism regulation unit and a gut microbiota regulation unit; the glucose and lipid metabolism regulation unit is composed of organic trivalent chromium, organic magnesium, and organic selenium; the gut microbiota regulation unit is composed of psyllium husk extract and microencapsulated compound probiotics. The metabolic environment protection system includes a neuroendocrine homeostasis unit and a vascular health protection unit; the neuroendocrine homeostasis unit is composed of Ashwagandha extract, L-theanine, and γ-aminobutyric acid; the vascular health protection unit is composed of nattokinase, phytosterol esters, grape seed extract, and deep-sea fish oil extract.

[0008] According to an embodiment of the present invention, by weight, the oat β-glucan extract comprises 120-180 parts, the quinoa polysaccharide extract comprises 5 parts, and the small molecule peptide mixture comprises 110-150 parts; the small molecule peptide mixture is whey protein peptide extract and soy protein isolate extract, with a mass ratio of 1.4-1.8:1. For example, the whey protein peptide extract has a molecular weight <1000 Da, and the soy protein isolate extract has a molecular weight <1000 Da.

[0009] According to an embodiment of the present invention, in the basic nutritional fortification and antioxidant unit, the chelated / organic mineral complex includes 0.12-0.18 parts of glycine chelated iron, 0.08-0.12 parts of zinc gluconate, 7-9 parts of calcium carbonate, and 18-22 parts of potassium chloride, wherein the chelation rate of glycine chelated iron is ≥95%; the vitamin complex includes a B vitamin complex, 0.00008-0.00012 parts of vitamin D3, and 0.8-1.2 parts of natural fruit and vegetable source vitamin C, wherein the B vitamin complex includes 0.012-0.018 parts of vitamin B1, 0.012-0.018 parts of vitamin B2, 0.015-0.025 parts of vitamin B6, and 0.000025-0.000035 parts of vitamin B12.

[0010] According to an embodiment of the present invention, in the glycolipid metabolism regulation unit, the content of organic trivalent chromium is 0.0004-0.0006 parts, the content of organic magnesium is 2.5-3.5 parts, and the content of organic selenium is 0.0004-0.0006 parts; According to an embodiment of the present invention, the organic trivalent chromium is chromium pyridinecarboxylate, the organic magnesium is magnesium gluconate, and the organic selenium is selenium-enriched yeast; the molar ratio of chromium pyridinecarboxylate, magnesium gluconate, and selenium-enriched yeast is calculated based on the mass of chromium, magnesium, and selenium contained therein, specifically (0.7-1.0):(5000-6000):(0.8-1.2).

[0011] According to an embodiment of the present invention, the intestinal microecological regulation unit contains 50-70 parts of psyllium husk extract and 8-12 billion microencapsulated compound probiotics, wherein the compound probiotics are Bifidobacterium and Lactobacillus, and the ratio of their live bacteria is 1:1.

[0012] According to an embodiment of the present invention, in the neuroendocrine homeostasis unit, the content of Ashwagandha extract is 3-5 parts, the content of L-theanine is 1-2 parts, and the content of γ-aminobutyric acid is 0.5-1 parts; in the vascular health protection unit, the content of nattokinase is 1000-2000 FU, the content of phytosterol esters is 8-12 parts, the content of grape seed extract is 1-2 parts, and the content of deep-sea fish oil extract is 2-3 parts, and the mass ratio of DHA to EPA in the deep-sea fish oil extract is 2:1.

[0013] According to an embodiment of the present invention, the Bifidobacterium is selected from Bifidobacterium animalis Bb-12 and Bifidobacterium triple live bacteria, and the lactic acid bacteria is selected from Lactobacillus plantarum LP299v and Lactobacillus acidophilus LA-5.

[0014] According to another aspect of the present invention, a method for preparing a complete nutritional complex is provided, comprising the following steps: (1) Pretreatment of raw materials, including preparing each raw material according to the predetermined ratio, sieving the raw materials, storing the microencapsulated compound probiotics at low temperature and away from light, and vacuum drying the heat-sensitive raw materials. (2) Graded mixing: including: In the first stage, all the raw materials of the nutrient foundation system are put into a three-dimensional mixer and mixed for 15-20 minutes at a speed of 100-120 r / min to obtain the nutrient supply base. In the second stage, the raw materials for the metabolic regulation core system are added to the nutrient supply base, and mixing continues for 10-15 minutes to obtain the core complex; and In the third stage, other ingredients besides the heat-sensitive components of the metabolic environment protection system and the microencapsulated compound probiotics are added to the core complex. Mix for 8-10 minutes, and finally add the heat-sensitive raw materials and microencapsulated compound probiotics. Mix at low speed for 5 minutes at a speed of 50-60 r / min to obtain a semi-finished product of the complete nutritional complex. (3) Depending on the product form requirements, the semi-finished product is made into powder, granules or tablets. Before final packaging, quality testing can also be carried out, including testing the moisture content, probiotic live bacteria count, raw material purity and heavy metal content of the semi-finished product. The moisture content is ≤5%, and packaging is carried out after passing the test.

[0015] According to an embodiment of the present invention, the heat-sensitive raw material includes vitamin C and nattokinase.

[0016] This invention, through scientific raw material selection, precise formulation design, and standardized preparation process, relies on the core logic of "specific material carrier + human physiological laws" to achieve the following beneficial effects: 1. Enabling Nutrition and Metabolism as the Foundation of Life Activities: This invention takes the physiological principle of "nutrition as the foundation of metabolism" as its core. The specific material combination of the nutrition foundation system fills the basic nutritional gap in modern populations, providing sufficient raw materials for metabolic activities. The material combination of the metabolic regulation core system and the metabolic environment protection system synergistically optimizes the metabolic network, follows the laws of human metabolism, and achieves efficient conversion of nutrients. It improves the physiological state of the human body from two fundamental levels of life, forming a complete closed loop of "material supply - law adaptation - effect implementation".

[0017] 2. Significant synergistic effect: In the glucose and lipid metabolism regulation unit, chromium picolinate, magnesium gluconate, and selenium-enriched yeast are combined in a specific molar ratio of (0.7-1.0):(5000-6000):(0.8-1.2) based on the mass of chromium, magnesium, and selenium. This ratio strictly conforms to the human glucose and lipid metabolism pattern and has a significant effect on improving the glucose uptake rate of 3T3-L1 adipocytes. The combination of substances in the vascular health protection unit follows the vascular health maintenance pattern and can increase the expression level of tight junction protein in vascular endothelial cells, with a significant synergistic effect.

[0018] 3. The three-tiered system design is scientific and conforms to physiological laws: The division of the "nutritional foundation system - metabolic regulation core system - metabolic environment protection system" strictly follows the natural physiological law of the human body: "raw material supply → core regulation → environmental protection". Each system and functional unit is composed of specific material combinations. The selection and ratio of materials in each system and unit are in line with the corresponding physiological laws, forming a close functional complementarity and synergy. Through comparative experiments of functional unit combinations, it is verified that the effect of the complete system is significantly better than the effect of a single system or any combination of two systems. Attached Figure Description

[0019] Figure 1 This is a graph comparing the phosphorylation levels of IRS-1 in different experimental groups according to the embodiments of the present invention. Figure 2 This is a graph comparing the expression levels of PI3K protein in different experimental groups according to an embodiment of the present invention. Figure 3 This is a graph comparing the Akt protein expression levels in different experimental groups according to an embodiment of the present invention. Detailed Implementation

[0020] The present invention will be further described in detail below with reference to embodiments. The following description is merely exemplary and is not intended to limit the application or use of this disclosure.

[0021] Unless otherwise specified, the experimental methods mentioned in the examples are conventional methods; unless otherwise specified, the experimental materials used in the examples can be purchased from conventional reagent and raw material stores.

[0022] Example 1: Preparation of a complete nutrient complex (powder) Based on one dose per person per day, the formula is as follows (the combination of substances in each system strictly follows the corresponding physiological laws, and the proportions are precise): 1. Nutritional Foundation System: 15g oat β-glucan, 8g whey protein peptide, 5g soy protein isolate peptide (small molecule peptide mass ratio 1.6:1, adapted to the slow energy release pattern); 15mg glycine chelated iron, 10mg zinc gluconate, 800mg calcium carbonate, 2000mg potassium chloride; 1.5mg vitamin B1, 1.5mg vitamin B2, 2mg vitamin B6, 3μg vitamin B12, 10μg vitamin D3, 100mg natural fruit and vegetable source vitamin C (adapted to the nutrient absorption and antioxidant pattern).

[0023] 2. Core metabolic regulation system: 50 μg chromium pyridinecarboxylate, 300 mg magnesium gluconate, 50 μg selenium-enriched yeast (molar ratio 0.8:5500:1, calculation basis: mass of chromium, magnesium, and selenium; magnesium gluconate contains approximately 9.8% magnesium, 300 mg magnesium gluconate contains approximately 29.4 mg magnesium; selenium-enriched yeast contains approximately 0.1% selenium, 50 μg selenium-enriched yeast contains approximately 0.05 μg selenium; chromium pyridinecarboxylate contains approximately 12% chromium, 50 μg chromium pyridinecarboxylate contains approximately 6 μg chromium, calculated molar ratio 0.8:5500:1); 6 g psyllium husk, 10 billion CFU of microencapsulated probiotics (Bifidobacterium:Lactobacillus = 1:1, adapted to the intestinal microecological balance).

[0024] 3. Metabolic Environment Protection System: Ashwagandha extract 400mg, L-theanine 150mg, γ-aminobutyric acid 75mg (adapted to the neuroendocrine balance); nattokinase 1500FU, phytosterol esters 1000mg, grape seed extract 150mg, deep-sea fish oil extract 250mg (DHA:EPA=2:1, adapted to the vascular health maintenance pattern).

[0025] Preparation steps: 1. Raw material pretreatment: All raw materials are sieved through a 90-mesh sieve. Heat-sensitive raw materials (vitamin C, nattokinase) are vacuum dried (30℃, 0.09MPa). Probiotics are stored at low temperature and protected from light (following the storage rules for heat-sensitive substances and probiotics).

[0026] 2. Graded mixing: First, mix the nutritional foundation system ingredients (18 minutes, 110 rpm), then add the metabolic regulation core system ingredients (12 minutes, 110 rpm), and finally add the non-heat-sensitive protection system ingredients (9 minutes, 110 rpm). Add the heat-sensitive ingredients and probiotics (5 minutes, 55 rpm) to ensure that all substances are mixed evenly and that their activity is not destroyed.

[0027] 3. Molding and Packaging: The semi-finished product is packaged in nitrogen-filled powder to obtain a complete nutrient complex powder, which prevents the raw materials from oxidizing and retains the activity of the substances.

[0028] Example 2: Experimental Verification of Synergistic Effect of Glucose and Lipid Metabolism Regulatory Unit Experimental objective: The purpose of this invention is to verify the synergistic effect and molecular mechanism of a specific molar ratio combination of substances in the glucose and lipid metabolism regulatory unit, to verify the difference in effect when deviating from the molar ratio, and to compare the effect of the specific molar ratio combination of this invention with similar combinations of substances in the prior art (without clear ratios or regular matching).

[0029] Experimental materials: Chromium pyridinecarboxylate, magnesium gluconate, selenium-enriched yeast, 3T3-L1 adipocytes, C2C12 skeletal muscle cells, cell culture medium, insulin, glucose assay kit, and Western blot (WB) related reagents. Experimental methods Group design: A blank group (a), an experimental group (b) (mixed according to the molar ratio of 0.8:5500:1 in Example 1 of this invention, which is within a specific range based on the mass of chromium, magnesium and selenium elements and is suitable for the human glucose and lipid metabolism pattern), a deviating molar ratio group 1 (c) (0.5:4000:0.6, which deviates from the range defined by this invention and is not suitable for the glucose and lipid metabolism pattern), a deviating molar ratio group 2 (d) (1.2:7000:1.4, which deviates from the range defined by this invention and is not suitable for the glucose and lipid metabolism pattern), and a control group (e) (the three substances are mixed in equal mass).

[0030] Cell treatment: 3T3-L1 adipocytes and C2C12 skeletal muscle cells were seeded into culture plates and cultured to the logarithmic growth phase. The corresponding concentration of experimental samples was added to each group and incubated for 24 hours. The blank group was treated with an equal amount of culture medium, following the cell metabolism pattern.

[0031] Indicator Testing: Glucose uptake detection: Using a glucose detection kit, the residual glucose content in the cell culture medium was measured, and the glucose uptake rate was calculated to reflect the effect of glucose metabolism regulation. Signaling pathway protein detection: Western blot was used to detect the phosphorylation level of IRS-1 and the expression levels of PI3K and Akt proteins to verify the molecular mechanism of the specific molar ratio combination of the present invention in regulating glucose and lipid metabolism and to clarify the intrinsic relationship between the combination of substances and the adaptation of physiological laws.

[0032] Experimental results: 1. Glucose uptake rate: The glucose uptake rate in the blank group was only 12.3%; the glucose uptake rate in the experimental group was as high as 82.4%; the glucose uptake rates in the deviation molar ratio groups 1 and 2 were 22.1% and 24.3% respectively, which were higher than the blank group, but much lower than the experimental group, with no obvious synergistic effect; the glucose uptake rate in the control group was only 38.2%, which was higher than the deviation molar ratio groups, but also much lower than the experimental group, with a weak synergistic effect.

[0033] 2. Signaling pathway protein expression, see appendix for details. Figure 1-3 The results showed that the phosphorylation level of IRS-1 and the expression levels of PI3K and Akt proteins in the experimental group were significantly higher than those in the other groups, which were 3.2 times, 2.8 times, and 2.6 times higher than those in the blank group, respectively. This demonstrates that the specific molar ratio combination of the present invention can effectively activate the insulin signaling pathway and adapt to the physiological rhythm of human glucose and lipid metabolism. The protein expression levels in the groups deviating from the molar ratio and the control group were not significantly increased, and there was no synergistic effect at the mechanistic level.

[0034] Example 3: Human Trial Experiment Experimental objective: This study aims to verify the practical application effect of the complete nutritional complex of this invention on sub-healthy individuals, examine the dual efficacy of nutritional supplementation and metabolic regulation, demonstrate its practical applicability in line with human physiological laws, and provide clinical data support for the sufficiency of the technical solution disclosure.

[0035] Experimental subjects: Sixty sub-healthy volunteers aged 25-55 years with insufficient nutritional intake and mild metabolic disorders were selected. Inclusion criteria: fasting blood glucose in the borderline range of 5.6-6.9 mmol / L, high body fat percentage, irregular daily diet, and easy fatigue. Patients with organic diseases such as diabetes and hypertension were excluded. They were randomly divided into an experimental group and a control group, with 30 people in each group. There were no significant differences in age, gender, and basic physical indicators between the two groups (P>0.05).

[0036] Experimental methods: The experimental group took one dose of the complete nutritional complex prepared in Example 1 daily, while the control group took a placebo (containing only basic starch carriers, without active nutrients and metabolic regulatory components). The experimental period was 45 days. During the experimental period, the subjects were required to maintain their original diet and lifestyle habits and not take other similar functional foods or health products.

[0037] Testing indicators: Fasting blood glucose, triglycerides, total cholesterol, body fat percentage, and visual analog scale (VAS) scores were measured before and after the experiment. The data were collected and statistically analyzed.

[0038] Experimental results: After the experiment, the fasting blood glucose level in the experimental group dropped to the normal range of 4.8-5.5 mmol / L, the triglyceride and total cholesterol levels decreased by 18.2% and 15.6% respectively, the body fat percentage decreased by 2.3%, and the fatigue VAS score decreased by 42.7%. All indicators showed significant improvement compared with before the experiment (P<0.05). In the control group, there were no significant changes in any indicators before and after the experiment, and there was no statistical difference (P>0.05).

[0039] Experimental conclusion: The complete nutritional complex of this invention can effectively improve the nutritional imbalance and metabolic disorder in sub-healthy individuals, achieving the dual effects of nutritional supplementation and metabolic regulation. It has no adverse reactions with long-term use, is highly safe, and the technical solution can be stably implemented. It conforms to the physiological laws of the human body and has strong practicality and market application value.

[0040] Example 4: Comparative Experiment of Synergistic Effect of Three-Level System Experimental objective: This invention verifies the scientific validity of its three-tiered system of "nutritional foundation-metabolic regulation-environmental protection," demonstrating that the synergistic effect of the complete system is superior to that of a single system or a combination of two systems, highlighting the necessity of system design that aligns with human physiological laws.

[0041] Experimental Groups: Group A (complete three-level system, i.e., the formula of Example 1), Group B (nutritional foundation system only), Group C (nutritional foundation + metabolic regulation core system), and Group D (metabolic regulation + environmental protection system) were set up. Eighty volunteers who met the inclusion criteria of Example 4 were selected and randomly divided into four groups of 20 each. The experimental period was 45 days, and the detection indicators were the same as those in Example 3.

[0042] Experimental results: Group A subjects showed a comprehensive improvement rate of 78.5% across all indicators, with a 1.8-fold increase in metabolic network optimization efficiency; Group B only saw improvement in basic nutritional indicators, with a comprehensive improvement rate of 32.1%; Group C showed a comprehensive improvement rate of 56.3%, with limited metabolic regulation effects; Group D showed a comprehensive improvement rate of 49.7%, lacking basic nutritional support, and the effects were not lasting. The synergistic effect of the complete three-tiered system was significantly better than other single / dual system combinations, achieving a synergistic effect of 1+1+1>3.

[0043] Experimental conclusion: The three-level functional system of this invention is designed to conform to the physiological laws of the human body, namely "nutrient supply → core metabolism → internal environment homeostasis". The various systems support each other and work synergistically, resulting in good effects.

[0044] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The descriptions of the above embodiments are only for the purpose of helping to understand the device and core ideas of the present invention. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of the present invention. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A complete nutritional complex based on the synergistic regulation of nutrition and metabolism, characterized in that, include: A three-tiered functional synergistic system comprising a foundational nutrition system, a core metabolic regulation system, and a metabolic environment protection system; The nutritional foundation system includes a slow-release energy supply unit and a basic nutritional fortification and antioxidant unit. The slow-release energy supply unit consists of oat β-glucan extract, quinoa polysaccharide extract, and a mixture of small molecule peptides, wherein the small molecule peptide mixture is whey protein peptide extract and soy protein isolate extract. The basic nutritional fortification and antioxidant unit consists of a chelated / organic mineral complex and a vitamin complex. The core metabolic regulation system includes a glucose and lipid metabolism regulation unit and a gut microbiota regulation unit; the glucose and lipid metabolism regulation unit is composed of organic trivalent chromium, organic magnesium, and organic selenium; the gut microbiota regulation unit is composed of psyllium husk extract and microencapsulated compound probiotics. The metabolic environment protection system includes a neuroendocrine homeostasis unit and a vascular health protection unit; the neuroendocrine homeostasis unit is composed of Ashwagandha extract, L-theanine, and γ-aminobutyric acid; the vascular health protection unit is composed of nattokinase, phytosterol esters, grape seed extract, and deep-sea fish oil extract.

2. The complete nutritional complex based on the synergistic regulation of nutrition and metabolism according to claim 1, characterized in that, By weight, the oat β-glucan extract is 120-180 parts, the quinoa polysaccharide extract is 5 parts, and the small molecule peptide mixture is 110-150 parts; the small molecule peptide mixture is whey protein peptide extract and soy protein isolate extract, with a mass ratio of 1.4-1.8:

1.

3. The complete nutritional complex based on the synergistic regulation of nutrition and metabolism according to claim 1, characterized in that, In the basic nutritional fortification and antioxidant unit, the chelated / organic mineral complex includes 0.12-0.18 parts of glycine chelated iron, 0.08-0.12 parts of zinc gluconate, 7-9 parts of calcium carbonate, and 18-22 parts of potassium chloride, with a chelation rate of ≥95% for the glycine chelated iron; the vitamin complex includes a B vitamin complex, 0.00008-0.00012 parts of vitamin D3, and 0.8-1.2 parts of natural fruit and vegetable source vitamin C, wherein the B vitamin complex includes 0.012-0.018 parts of vitamin B1, 0.012-0.018 parts of vitamin B2, 0.015-0.025 parts of vitamin B6, and 0.000025-0.000035 parts of vitamin B12.

4. The complete nutritional complex based on the synergistic regulation of nutrition and metabolism according to claim 1, characterized in that, In the glucose and lipid metabolism regulation unit, the content of organic trivalent chromium is 0.0004-0.0006 parts, the content of organic magnesium is 2.5-3.5 parts, and the content of organic selenium is 0.0004-0.0006 parts.

5. The complete nutritional complex based on the synergistic regulation of nutrition and metabolism according to claim 4, characterized in that, The organic trivalent chromium is chromium pyridinecarboxylate, the organic magnesium is magnesium gluconate, and the organic selenium is selenium-enriched yeast; the molar ratio of chromium pyridinecarboxylate, magnesium gluconate, and selenium-enriched yeast is calculated based on the mass of chromium, magnesium, and selenium contained therein, specifically (0.7-1.0):(5000-6000):(0.8-1.2).

6. The complete nutritional complex based on the synergistic regulation of nutrition and metabolism according to claim 1, characterized in that, The intestinal microecological regulation unit contains 50-70 parts of psyllium husk extract and 8-12 billion microencapsulated compound probiotics, wherein the compound probiotics are Bifidobacterium and Lactobacillus, with a live bacteria ratio of 1:

1.

7. The complete nutritional complex based on the synergistic regulation of nutrition and metabolism according to claim 1, characterized in that, In the neuroendocrine homeostasis unit, the content of Ashwagandha extract is 3-5 parts, the content of L-theanine is 1-2 parts, and the content of γ-aminobutyric acid is 0.5-1 parts; in the vascular health protection unit, the content of nattokinase is 1000-2000 FU, the content of phytosterol esters is 8-12 parts, the content of grape seed extract is 1-2 parts, and the content of deep-sea fish oil extract is 2-3 parts, and the mass ratio of DHA to EPA in the deep-sea fish oil extract is 2:

1.

8. The complete nutritional complex based on the synergistic regulation of nutrition and metabolism according to claim 6, characterized in that, The Bifidobacterium is selected from Bifidobacterium animalis Bb-12 and Bifidobacterium triple live bacteria, and the lactic acid bacteria is selected from Lactobacillus plantarum LP299v and Lactobacillus acidophilus LA-5.

9. A method for preparing the complete nutritional complex according to any one of claims 1-8, comprising the following steps: (1) Pretreatment of raw materials, including preparing each raw material according to the predetermined ratio, sieving the raw materials, storing the microencapsulated compound probiotics at low temperature and away from light, and vacuum drying the heat-sensitive raw materials. (2) Graded mixing: including: In the first stage, all the raw materials of the nutrient foundation system are put into a three-dimensional mixer and mixed for 15-20 minutes at a speed of 100-120 r / min to obtain the nutrient supply base. In the second stage, the raw materials for the metabolic regulation core system are added to the nutrient supply base, and mixing continues for 10-15 minutes to obtain the core complex; and In the third stage, other ingredients besides the heat-sensitive components of the metabolic environment protection system and the microencapsulated compound probiotics are added to the core complex. Mix for 8-10 minutes, and finally add the heat-sensitive raw materials and microencapsulated compound probiotics. Mix at low speed for 5 minutes at a speed of 50-60 r / min to obtain a semi-finished product of the complete nutritional complex. (3) Based on the product form requirements, the semi-finished product is made into powder, granules or tablets.

10. The preparation method according to claim 9, wherein the heat-sensitive raw material includes vitamin C and nattokinase.

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