Biopharmaceutical three-dosage-form integrated blister packaging machine

Abstract

The invention discloses a biopharmaceutical three-dosage-form integrated blister packaging machine, and relates to the technical field of biopharmaceutical packaging machines, the biopharmaceutical three-dosage-form integrated blister packaging machine comprises a machine base, a blister forming assembly, a product filling assembly and a post-processing assembly; the bubble cap forming assembly comprises a film loading roller, multiple sets of guide rollers, a pair of heating plates, a step-by-step forming component and a tensioning roller, the film loading roller is rotationally arranged in the machine base, the multiple sets of guide rollers are rotationally arranged in the machine base, the pair of heating plates are symmetrically arranged in the machine base, and the tensioning roller is rotationally arranged in the machine base; the heating plate is arranged on one side of the step-by-step forming part; the product filling assembly comprises a feeding wheel, a filling plate, a plurality of sets of fixing plates, a plurality of sets of flow guide plates, a plurality of sets of vibration feeding components and a vacuum impurity removal component. According to the blister packaging machine, medicines of different specifications and dosage forms can be packaged on the same aluminum-plastic plate according to actual needs, and the packaging flexibility of the blister packaging machine is improved.

Description

Technical Field

[0001] This application relates to the field of biopharmaceutical packaging machine technology, and in particular to a biopharmaceutical three-dosage integrated blister packaging machine. Background Technology

[0002] A biopharmaceutical blister packaging machine is a packaging device that seals medicines between a transparent plastic film blister and a base plate (such as aluminum foil). The main working processes of a biopharmaceutical blister packaging machine include: material heating, blister forming, product filling, heat sealing, batch number imprinting, punching and cutting, and finished product conveying.

[0003] Existing biopharmaceutical blister packaging machines typically package the same drug, i.e., they process drugs of the same specification and dosage form. They cannot package drugs of different specifications and dosage forms on an aluminum-plastic blister pack according to actual needs. They cannot meet the needs of packaging drugs of multiple specifications and dosage forms according to daily / dosage. Furthermore, the blister forming process is carried out by one-time stamping, resulting in thinner blister walls and poor forming effect. Summary of the Invention

[0004] To address the problem that existing biopharmaceutical blister packaging machines cannot integrate and package multiple dosage forms of medicines onto a single aluminum-plastic plate according to actual needs, this application provides a biopharmaceutical three-dosage-form integrated blister packaging machine.

[0005] This application provides an integrated blister packaging machine for three dosage forms in biopharmaceuticals, employing the following technical solution: A biopharmaceutical three-dosage integrated blister packaging machine includes: a machine base, a blister forming assembly, a product filling assembly, and a post-processing assembly. The blister forming assembly is disposed within the machine base and includes a film loading roller, multiple sets of guide rollers, a pair of heating plates, a step-forming component, and a tension roller. The film loading roller is rotatably disposed within the machine base, as are the multiple sets of guide rollers. The pair of heating plates are symmetrically disposed within the machine base. The step-forming component is located on the side of the heating plates opposite to the guide rollers and is used for pre-forming and positive pressure forming of the plastic blister pack. The tension roller is rotatably disposed within the machine base and is located on the side of the step-forming component opposite to the heating plates. The product filling assembly is fixedly disposed on the upper part of the machine base. The product filling assembly includes a feeding wheel, a packing plate, multiple sets of fixed plates, multiple sets of guide plates, multiple sets of vibrating feeding components, and a vacuum cleaning component. The feeding wheel is rotatably mounted on one side of the machine base. The packing plate is fixedly mounted above the machine base. Multiple sets of fixed plates are evenly distributed above the packing plate. Multiple sets of guide plates are correspondingly mounted to multiple sets of fixed plates, and the guide plates and fixed plates cooperate to form a feeding channel. Multiple sets of vibrating feeding components are one-to-one with multiple sets of guide plates for feeding material into the feeding channel. The vacuum cleaning component is located on the side of the guide plate away from the feeding wheel. The post-processing component is fixedly mounted on the side of the vacuum cleaning component away from the guide plate and is used for heat sealing, batch number imprinting, and punching.

[0006] By adopting the above technical solution, the plastic film is unwound and supported by a film loading roller. After being heated by a heating plate, the plastic film is conveyed to a step-forming component for pre-pressing and positive-pressing to form blister packs. Subsequently, the medicine is filled into the blister packs through the cooperation of multiple sets of vibrating feeding components and unloading channels. Post-processing components are used to heat-seal, imprint batch numbers, and punch the plastic film blister packs.

[0007] Optionally, the step-forming component includes a forming box, a lifting cam servo drive, a roller seat, multiple forming columns, a forming guide plate, a lower water tank plate, and a lower forming mold. The forming box is fixedly installed inside the machine base, the lifting cam servo drive is rotatably installed inside the forming box, and the roller seat is slidably installed in the forming box.

[0008] By adopting the above technical solution, the roller seat is driven to perform lifting by driving the lifting cam to rotate.

[0009] Optionally, multiple forming columns are fixedly installed inside the forming box, the forming guide plate is slidably sleeved on the outside of the multiple forming columns, and the lower water tank plate and the lower forming mold are sequentially fixedly installed above the forming guide plate.

[0010] By adopting the above technical solution, multiple forming columns play a role in assembling, limiting, and guiding the lifting of the forming guide plate.

[0011] Optionally, the step-forming component further includes an upper mold base, an air duct mold, a preforming mold, and multiple sets of preforming cylinders. The upper mold base is fixedly connected to the upper ends of multiple forming columns. The air duct mold is fixedly connected to the side of the upper mold base close to the lower forming mold. The preforming mold is slidably disposed within the air duct mold. All sets of preforming cylinders are fixedly disposed above the upper mold base.

[0012] By employing the above technical solution, the air channel mold and the lower forming mold are closed by driving the lifting cam to rotate. Subsequently, the plastic film is pre-formed by pressing down the pre-forming mold. After pre-forming, the blister is positively pressure-formed by filling the space between the pre-forming mold and the lower forming mold with compressed air.

[0013] Optionally, the blister forming assembly further includes a housing, multiple sets of clamping cylinders, and a pair of clamping rollers. The housing is fixedly installed inside the machine base, the tensioning rollers are rotatably installed inside the housing, the pair of clamping cylinders are fixedly installed on the outside of the housing, and the pair of clamping rollers are installed on the outside of the tensioning rollers.

[0014] By adopting the above technical solution, the clamping roller can limit the plastic film blister pack located outside the tensioning roller by controlling the extension and retraction of multiple sets of clamping cylinders, which facilitates the subsequent pulling and moving of the plastic film blister pack by the rotation of the tensioning roller.

[0015] Optionally, the vibratory feeding component includes a vibratory plate, a pair of guide troughs, multiple sets of discharge cover plates, and a discharge sensor. The vibratory plate is positioned above the guide plate, and a pair of guide troughs are provided inside the vibratory plate. The pair of guide troughs are connected to the discharge channel. The multiple sets of discharge cover plates are fixedly positioned above the packing plate and are configured in conjunction with the multiple sets of guide plates. The discharge sensor is fixedly positioned below the vibratory plate and is configured corresponding to the discharge channel.

[0016] By adopting the above technical solution, the medicine is orderly conveyed into the discharge channel along the guide chute under the vibration feeding action of the vibratory feeder. Simultaneously, the installation of multiple discharge covers prevents misalignment of medicines of different specifications or dosage forms. The discharge sensors detect the medicine falling into the discharge channel, thus counting the amount of medicine being filled.

[0017] Optionally, the vibratory feeding component further includes a fixed frame, a storage bin, a feeding cylinder, and a baffle plate. The fixed frame is fixedly installed above the vibratory plate, the storage bin is fixedly connected to the fixed frame, the feeding cylinder is fixedly installed below the fixed frame, and the baffle plate is fixedly connected to the telescopic end of the feeding cylinder.

[0018] By adopting the above technical solution, the horizontal movement of the baffle plate is regulated by controlling the extension and retraction of the feeding cylinder, thereby controlling the material discharge state of the storage hopper.

[0019] Optionally, the vacuum cleaning component includes a cleaning hood and an extraction pipe. The cleaning hood is fixedly installed above the packing plate, and a filter screen is fixedly installed at the lower opening of the cleaning hood. The extraction pipe is fixedly installed above the cleaning hood.

[0020] By adopting the above technical solution, the air inside the impurity removal hood is continuously extracted through the air extraction pipe, thereby adsorbing and removing impurities inside the blister pack.

[0021] Optionally, the post-processing components include a dust cover, a limiting roller, a rotating frame, an anilox roller, an aluminum foil loading roller, a guide limiting roller, a drive housing, an embossing die, and a punching die. The dust cover is fixedly installed on one side of the machine base, the limiting roller is rotatably installed inside the dust cover, the rotating frame is rotatably installed inside the dust cover, and the anilox roller is rotatably connected to the side of the rotating frame close to the limiting roller.

[0022] By adopting the above technical solution, the anilox roller is driven to rotate by rotating the frame, and the anilox roller heat-seals the aluminum foil and plastic film blister pack.

[0023] Optionally, the aluminum foil loading roller is rotatably disposed inside the dust cover, multiple sets of guide and limiting rollers are rotatably disposed inside the dust cover, the drive housing is fixedly disposed inside the dust cover, and the embossing die and the punching die are respectively fixedly disposed at both ends of the drive housing.

[0024] By adopting the above technical solution, the heat-sealed plastic film blister packs are sequentially passed through an embossing mold and a die-cutting mold to perform batch number embossing and die-cutting processes, respectively.

[0025] In summary, the embodiments of the present invention provide an integrated blister packaging machine for three dosage forms in biopharmaceuticals, which includes at least one of the following beneficial technical effects: 1. The plastic film blister pack is formed in stages by combining preforming and positive pressure forming, which improves the uniformity, smoothness and aesthetics of the plastic film blister pack forming process; 2. By employing multiple sets of vibrating feeding components, drugs of different specifications and dosage forms are accurately filled in stages, enabling integrated packaging of multiple dosage forms of drugs on the same aluminum-plastic plate; 3. By using a vibrating feeding component in conjunction with a guide plate, multi-dosage form medicines can be accurately filled, avoiding damage or incomplete filling during the filling process; 4. By setting up a vacuum impurity removal component, foreign matter generated during the filling process of the medicine can be removed, thereby improving the product qualification rate. Attached Figure Description

[0026] Figure 1 A schematic diagram of the structure of a biopharmaceutical three-dosage integrated blister packaging machine provided in an embodiment of the present invention; Figure 2 A three-dimensional structural schematic diagram of a biopharmaceutical three-dosage integrated blister packaging machine provided in an embodiment of the present invention; Figure 3 for Figure 2 Enlarged view of a portion of the structure at point A; Figure 4 for Figure 2 Enlarged view of the structure at point B in the middle; Figure 5 for Figure 2 Enlarged view of the structure at point C; Figure 6 This is a schematic diagram of the step-forming component in a biopharmaceutical three-dosage integrated blister packaging machine provided in an embodiment of the present invention; Figure 7 A perspective view of the combined state of an integrated blister packaging machine for three dosage forms in biopharmaceuticals provided in an embodiment of the present invention; Figure 8 This is a schematic diagram of the structure of the guide plate in a three-dosage integrated blister packaging machine for biopharmaceuticals, provided in an embodiment of the present invention; Figure 9 This is a schematic diagram of the feeding cover plate in a three-dosage integrated blister packaging machine for biopharmaceuticals provided in an embodiment of the present invention; Figure 10 This is a schematic diagram of the structure of a vibrating feeding component in a biopharmaceutical three-dosage integrated blister packaging machine provided in an embodiment of the present invention; Figure 11 This is a cross-sectional view of a vibrating feeding component in a biopharmaceutical three-dosage integrated blister packaging machine provided in an embodiment of the present invention; Figure 12 for Figure 11 Enlarged view of the structure at point D.

[0027] Explanation of the markings in the image: 1. Base; 2. Blister forming assembly; 201. Film loading roller; 202. Guide roller; 203. Heating plate; 204. Tensioning roller; 205. Forming box; 206. Lifting cam servo drive; 207. Roller seat; 208. Forming column; 209. Forming guide plate; 210. Lower water tank plate; 211. Lower forming mold; 212. Upper mold base; 213. Air passage mold; 214. Preforming mold; 215. Preforming cylinder; 216. Box base; 217. Clamping cylinder; 218. Clamping roller; 3. Product filling components; 301. Feeding wheel; 302. Filler plate; 303. Fixing plate; 304. Guide plate; 305. Vibratory feeder; 306. Feed chute; 307. Fixing frame; 308. Storage hopper; 309. Feeding cylinder; 310. Baffle plate; 311. Impurity removal hood; 312. Air extraction pipe; 313. Assembly bracket; 314. Distributing shaft; 315. Feeding plate; 316. Drive motor; 317. Air cylinder; 318. Piston block; 319. Return spring; 320. Compression plate; 321. Air blowing pipe; 4. Post-processing components; 401. Dust cover; 402. Limiting roller; 403. Rotating frame; 404. Anilox roller; 405. Aluminum foil loading roller; 406. Guide limiting roller; 407. Drive box base; 408. Imprinting die; 409. Punching die; 5. Material feeding channel; 6. Material discharge cover plate; 7. Feed sensor. Detailed Implementation

[0028] The following is in conjunction with the appendix Figure 1-12 This application will be described in further detail. Example 1

[0029] Combination Figure 1 and Figure 2 This application discloses an integrated blister packaging machine for three dosage forms in biopharmaceuticals, comprising: a base 1, a blister forming assembly 2, a product filling assembly 3, and a post-processing assembly 4. In practical applications, the blister forming assembly 2 completes the heating of the plastic film and blister forming, the product filling assembly 3 accurately fills the corresponding blister with drugs of different specifications and dosage forms, and the post-processing assembly 4 sequentially completes the aluminum foil heat sealing, batch number imprinting, and die-cutting processes.

[0030] Combination Figure 1 , Figure 2 , Figure 3 and Figure 4 The blister forming assembly 2 is disposed within the machine base 1. The blister forming assembly 2 includes a film loading roller 201, multiple sets of guide rollers 202, a pair of heating plates 203, a step-forming component, and a tension roller 204. In practical applications, the film loading roller 201 is used to unwind and support the plastic film roll, the multiple sets of guide rollers 202 are used to traction and guide the plastic film roll, and the heating plates 203 are used to heat the plastic film. The heated plastic film forms multiple blister packs under the action of the step-forming component.

[0031] Combination Figure 1 and Figure 2 The film loading roller 201 is rotatably mounted inside the machine base 1. The film loading roller 201 is used to support the unwinding of the plastic film roll.

[0032] Combination Figure 1 and Figure 2 Multiple sets of guide rollers 202 are rotatably mounted inside the machine base 1. The plastic film is guided by the multiple sets of guide rollers 202 to facilitate subsequent forming processing of the plastic film.

[0033] Combination Figure 2 , Figure 3 and Figure 6 The step-forming component is located on the side of the heating plate 203 away from the guide roller 202, and is used for pre-forming and positive pressure forming of plastic blister packs. The step-forming component includes a forming box 205, a lifting cam servo drive 206, a roller seat 207, multiple forming columns 208, a forming guide plate 209, a lower water tank plate 210, and a lower forming mold 211. The forming box 205 is fixedly installed in the machine base 1, the lifting cam servo drive 206 is rotatably installed in the forming box 205, and the roller seat 207 is slidably installed in the forming box 205 and located above the lifting cam servo drive 206. The roller seat 207 is lifted by driving the lifting cam servo drive 206 to rotate.

[0034] Combination Figure 2 , Figure 3 and Figure 6 Multiple forming columns 208 are fixedly installed inside the forming box 205. A forming guide plate 209 is slidably sleeved on the outside of the multiple forming columns 208. A lower water tank plate 210 and a lower forming mold 211 are sequentially fixed above the forming guide plate 209. The multiple forming columns 208 serve to limit assembly and guide the lifting of the forming guide plate 209. The cooperation between the lower water tank plate 210 and the lower forming mold 211 supports and limits the plastic film.

[0035] Combination Figure 2 , Figure 3 and Figure 6 The step-forming components also include an upper mold base 212, an air duct mold 213, a pre-forming mold 214, and multiple sets of pre-forming cylinders 215. The upper mold base 212 is fixedly connected to the upper ends of multiple forming columns 208. The air duct mold 213 is fixedly connected to the side of the upper mold base 212 close to the lower forming mold 211. The pre-forming mold 214 is slidably disposed within the air duct mold 213. The multiple sets of pre-forming cylinders 215 are all fixedly disposed above the upper mold base 212, and the telescopic ends of the multiple sets of pre-forming cylinders 215 are all fixedly connected to the pre-forming mold 214. The forming guide plate 209 is lifted by driving the lifting cam servo drive 206 to rotate, so that the air duct mold 213 and the lower forming mold 211 close. Subsequently, the pre-forming mold 214 is pressed down by controlling the extension of the telescopic ends of the multiple sets of pre-forming cylinders 215, thus pre-forming the plastic film. After preforming is completed, the blister is subjected to positive pressure forming by filling the space between the preforming mold 214 and the lower forming mold 211 with compressed air.

[0036] Specifically, an air pipe is connected to one side of the air channel mold 213 for filling compressed air between the pre-forming mold 214 and the lower forming mold 211. An inlet pipe and an outlet pipe are connected to one side of the lower water tank plate 210 to deliver coolant into the lower water tank plate 210 and use heat conduction to cool and shape the formed plastic film blister.

[0037] It is worth noting that, in the mold-closed state, the contact surface between the lower forming mold 211 and the air passage mold 213 is in a sealed state. At the same time, the outer wall of the preforming mold 214 and the inner wall of the air passage mold 213 are also in a sliding sealed state.

[0038] Combination Figure 2 , Figure 3 and Figure 6 The tension roller 204 is rotatably mounted inside the machine base 1, located on the side of the step forming component away from the heating plate 203. Multiple bubble cover clearance grooves are provided on the outer side of the tension roller 204.

[0039] Combination Figure 6 The blister forming assembly 2 also includes a housing 216, multiple sets of clamping cylinders 217, and a pair of clamping rollers 218. The housing 216 is fixedly installed inside the machine base 1, and the tension roller 204 is rotatably installed inside the housing 216. The pair of clamping cylinders 217 are fixedly installed on the outside of the housing 216, and the pair of clamping rollers 218 are installed on the outside of the tension roller 204, and the pair of clamping rollers 218 are rotatably connected to the telescopic ends of the multiple sets of clamping cylinders 217. By controlling the extension of the telescopic ends of the multiple sets of clamping cylinders 217, the clamping rollers 218 can limit the plastic film blister pack located outside the tension roller 204, facilitating the subsequent pulling and moving of the plastic film blister pack by the rotation of the tension roller 204.

[0040] Combination Figure 1 and Figure 2 The product filling assembly 3 includes a feeding wheel 301, a filling plate 302, multiple sets of fixing plates 303, multiple sets of guide plates 304, multiple sets of vibrating feeding components, and a vacuum cleaning component. In practical applications, the feeding wheel 301 guides and limits the plastic film blister packs, and the plastic film blister packs are horizontally conveyed along the filling plate 302 under the traction of the post-processing assembly 4. The medicine is filled into the plastic film blister packs through the cooperation of multiple sets of vibrating feeding components and multiple sets of unloading channels 5. After the vacuum cleaning component removes impurities, the medicine filling process is completed.

[0041] Combination Figure 1 and Figure 2The feed roller 301 is rotatably mounted on one side of the machine base 1. The feed roller 301 guides the formed plastic film blister packs. The filler plate 302 is fixedly mounted above the machine base 1, and multiple sets of fixing plates 303 are evenly distributed above the filler plate 302. The filler plate 302 is used for horizontal conveying of the formed plastic film blister packs.

[0042] Combination Figure 7 and Figure 8 Multiple sets of guide plates 304 and multiple sets of fixed plates 303 are correspondingly arranged, and the guide plates 304 and fixed plates 303 cooperate to form a feeding channel 5. Multiple sets of vibrating feeding components are correspondingly arranged with the guide plates 304 to feed materials into the feeding channel 5. The vibrating feeding components include a vibrating plate 305 and a pair of guide troughs 306. The vibrating plate 305 is arranged above the guide plates 304, and a pair of guide troughs 306 are opened in the vibrating plate 305. The pair of guide troughs 306 are connected to the feeding channel 5. Under the vibrating feeding action of the vibrating plate 305, the medicine is orderly conveyed into the feeding channel 5 along the guide troughs 306.

[0043] Combination Figure 9 Multiple sets of discharge cover plates 6 are fixedly installed above the filler plate 302 and are configured in conjunction with multiple sets of guide plates 304. The multiple sets of discharge cover plates 6 prevent misalignment of filling of drugs of different specifications or dosage forms, thus ensuring the accuracy of drug filling.

[0044] Combination Figure 2 and Figure 10 The feeding sensor 7 is fixedly installed below the vibratory feeder 305 and corresponds to the feeding channel 5. By detecting the medicine falling into the feeding channel 5 through the feeding sensor 7, the medicine filling is counted, which facilitates subsequent recording and traceability of medicine filling.

[0045] Combination Figure 2 and Figure 5 The vibratory feeding component also includes a fixed frame 307, a storage bin 308, a feeding cylinder 309, and a baffle plate 310. The fixed frame 307 is fixedly installed above the vibratory feeder 305. The storage bin 308 is fixedly connected to the fixed frame 307. The feeding cylinder 309 is fixedly installed below the fixed frame 307. The baffle plate 310 is fixedly connected to the telescopic end of the feeding cylinder 309. The baffle plate 310 is configured to cooperate with the discharge port of the storage bin 308. The horizontal movement of the baffle plate 310 is controlled by extending and retracting the telescopic end of the feeding cylinder 309, thereby controlling the feeding state of the storage bin 308.

[0046] Combination Figure 1 and Figure 2The vacuum impurity removal component is located on the side of the guide plate 304 opposite to the feed wheel 301. The vacuum impurity removal component includes an impurity removal hood 311 and an extraction pipe 312. The impurity removal hood 311 is fixedly installed above the packing plate 302, and a filter screen is fixedly installed at the lower opening of the hood 311. The extraction pipe 312 is fixedly installed above the hood 311. Air is continuously extracted from the hood 311 through the extraction pipe 312, thereby adsorbing and removing impurities from the bubble cap.

[0047] Specifically, visual inspection devices are installed between the feed roller 301 and the packing plate 302, and between the impurity removal hood 311 and the dust cover 401. These devices employ five cameras to perform comprehensive inspection of the product before heat sealing from different angles and workstations. They can simultaneously inspect materials, blister formation, foreign objects, and stains in three dosage forms, detect material irregularities and foreign objects on the back of the drug, and accurately issue rejection commands, thereby improving the product qualification rate.

[0048] Combination Figure 1 and Figure 2 The post-processing component 4 is fixedly installed on the side of the vacuum cleaning component away from the guide plate 304, and is used for heat sealing, batch number imprinting, and die-cutting of plastic film blister packs. The post-processing component 4 includes a dust cover 401, a limiting roller 402, a rotating frame 403, an anilox roller 404, an aluminum foil loading roller 405, a guide limiting roller 406, a drive box base 407, an imprinting die 408, and a die-cutting die 409. The dust cover 401 is fixedly installed on one side of the machine base 1. The limiting roller 402 is rotatably installed inside the dust cover 401. The rotating frame 403 is rotatably installed inside the dust cover 401, and the anilox roller 404 is rotatably connected to the side of the rotating frame 403 close to the limiting roller 402. The anilox roller 404 and the limiting roller 402 are configured to cooperate with each other. The anilox roller 404 is driven to rotate by the rotating frame 403, so that the anilox roller 404 squeezes the aluminum foil into contact with the plastic film blister, and heat seals the aluminum foil and plastic film blister by the anilox roller 404.

[0049] Specifically, a stainless steel heating tube is installed inside the anilox roller 404 to heat the anilox roller 404. A PID automatic temperature control system is used to control the heating tube to keep the anilox roller 404 at a constant temperature.

[0050] It is worth noting that when the machine stops, the anilox roller 404 is raised by rotating the frame 403, which separates the anilox roller 404 from the plastic film blister on the outside of the limit roller 402, thus eliminating the phenomenon of blister deformation caused by heat radiation when the machine stops.

[0051] Combination Figure 1 and Figure 2The aluminum foil loading roller 405 is rotatably mounted inside the dust cover 401, and multiple sets of guide and limiting rollers 406 are also rotatably mounted inside the dust cover 401. The drive housing 407 is fixedly mounted inside the dust cover 401, and the embossing die 408 and the blanking die 409 are respectively fixedly mounted at both ends of the drive housing 407. The heat-sealed plastic film blister packs, guided by the multiple sets of guide and limiting rollers 406, pass sequentially through the embossing die 408 and the blanking die 409, respectively, for batch number embossing and blanking. Example 2

[0052] Combination Figure 10 , Figure 11 and Figure 12 Unlike Embodiment 1, the vibratory feeding component also includes an assembly bracket 313, a distributing shaft 314, a feeding plate 315, a drive motor 316, an air cylinder 317, a piston block 318, a return spring 319, a compression plate 320, and an air blowing pipe 321. The assembly bracket 313 is fixedly connected to the fixing frame 307. The assembly bracket 313 serves to limit the assembly of the distributing shaft 314. The distributing shaft 314 is rotatably mounted within the assembly bracket 313, and the feeding plate 315 is fixedly connected to the lower end of the distributing shaft 314. By rotating the feeding plate 315 driven by the distributing shaft 314, the medicine added to the vibratory plate 305 is smoothed and fed, improving the subsequent feeding effect of the medicine.

[0053] Combination Figure 10 and Figure 11 The drive motor 316 is fixedly mounted above the assembly bracket 313, and the output shaft of the drive motor 316 is fixedly connected to the material distribution shaft 314. The rotation of the material distribution shaft 314 is driven by controlling the operation of the drive motor 316.

[0054] Combination Figure 10 , Figure 11 and Figure 12 A pair of air cylinders 317 are fixedly mounted above the mounting bracket 313. A piston block 318 is slidably connected inside each air cylinder 317. A return spring 319 is fixedly connected between the piston block 318 and the air cylinder 317. A compression plate 320 is fixedly sleeved on the outer side of the distributing shaft 314, and the compression plate 320 cooperates with the piston block 318. The piston block 318 is intermittently compressed by the rotation of the compression plate 320 as the distributing shaft 314 rotates, thereby allowing the air inside the air cylinder 317 to be pulsedly discharged along the air blowing pipe 321.

[0055] Combination Figure 10 , Figure 11 and Figure 12The air cylinder 317 has a one-way air inlet and a one-way air outlet (such as a one-way air valve) on its outer side. One end of a pair of air blowing pipes 321 is connected to the one-way air outlet of the pair of air cylinders 317, and the other end of the pair of air blowing pipes 321 is connected to a pair of feeding channels 5. The compressed air is pulsedly sprayed into the feeding channels 5 through the air blowing pipes 321 to blow away the medicine falling out of the feeding channels 5, so as to avoid single medicine particles from clogging the feeding channels 5 and ensure the stability of the medicine feeding.

[0056] In practical use, the plastic film roll is fitted onto the outside of the film loading roller 201. Multiple guide rollers 202 guide the plastic film roll, and a pair of heating plates 203 heat the plastic film. The heated plastic film moves between the air channel mold 213 and the lower forming mold 211. Then, multiple pre-forming cylinders 215 drive the pre-forming mold 214 downwards to pre-form the plastic film. After pre-forming, the pre-forming mold 214 is reset. Finally, compressed air is injected between the pre-forming mold 214 and the plastic film to perform positive pressure forming of the plastic film blister.

[0057] The tension roller 204 and a pair of clamping rollers 218 are used to limit the shape of the formed plastic film blister pack. The rotation of the tension roller 204 can continuously pull the plastic film roll.

[0058] The plastic film blister packs move horizontally along the packing plate 302 under the guidance of the feed roller 301. Simultaneously, during this movement, the discharge cover plate 6 is positioned above the packing plate 302 to ensure accurate drug filling. During this process, the drugs in the vibratory feeder 305 fall sequentially along the discharge channel 5 via the guide trough 306. Drugs of different sizes and dosage forms are filled into the plastic film blister packs through the discharge channels 5, which are of different sizes and located at different positions. After filling, impurities are removed by adsorption using a purification hood 311 and a suction pipe 312. Furthermore, during the filling process, the drug falling through the discharge channel 5 is counted by the discharge sensor 7.

[0059] After impurity removal, the plastic film blister pack moves to the outside of the limiting roller 402. Simultaneously, aluminum foil rolls are mounted on the outside of the aluminum foil loading roller 405. After being guided by multiple sets of guiding and limiting rollers 406, the aluminum foil covers the opening side of the plastic film blister pack. Then, by controlling the rotation of the rotating frame 403, the anilox roller 404 compresses the aluminum foil and plastic film blister pack, and the cooperation between the anilox roller 404 and the limiting roller 402 performs a heat-sealing process on the aluminum foil and plastic film blister pack.

[0060] After heat sealing, the product passes through the embossing die 408 and the punching die 409 in sequence under the guidance of the guide limiting roller 406, and the batch number is embossed and punched respectively. The finished product after punching is discharged and conveyed through the matching conveying structure.

[0061] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A three-dosage integrated blister packaging machine for biopharmaceuticals, characterized in that, include: Base; A blister forming assembly is disposed within the machine base. The blister forming assembly includes a film loading roller, multiple sets of guide rollers, a pair of heating plates, a step forming component, and a tensioning roller. The film loading roller is rotatably disposed within the machine base, multiple sets of guide rollers are rotatably disposed within the machine base, a pair of heating plates are symmetrically disposed within the machine base, the step-forming component is disposed on the side of the heating plate away from the guide roller, and is used for pre-forming and positive pressure forming of plastic blister packs, and the tension roller is rotatably disposed within the machine base and is located on the side of the step-forming component away from the heating plate. The product filling assembly is fixedly installed above the machine base. The product filling assembly includes a feed wheel, a packing plate, multiple sets of fixed plates, multiple sets of guide plates, multiple sets of vibrating feeding components, and a vacuum impurity removal component. The feeding wheel is rotatably mounted on one side of the machine base, the packing plate is fixedly mounted on the top of the machine base, multiple sets of fixed plates are evenly distributed above the packing plate, multiple sets of guide plates are correspondingly mounted to multiple sets of fixed plates, and the guide plates and fixed plates cooperate to form a feeding channel, multiple sets of vibrating feeding components are correspondingly mounted to multiple sets of guide plates for feeding materials into the feeding channel, and the vacuum impurity removal component is mounted on the side of the guide plate away from the feeding wheel; The post-processing component is fixedly installed on the side of the vacuum cleaning component away from the guide plate, and is used for heat sealing, batch number imprinting and punching.

2. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 1, characterized in that: The step-forming component includes a forming box, a lifting cam servo drive, a roller seat, multiple forming columns, a forming guide plate, a lower water tank plate, and a lower forming mold. The forming box is fixedly installed inside the machine base, the lifting cam servo drive is rotatably installed inside the forming box, and the roller seat is slidably installed inside the forming box and located above the lifting cam servo drive.

3. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 2, characterized in that: Multiple forming columns are fixedly installed inside the forming box. The forming guide plate is slidably sleeved on the outside of the multiple forming columns. The lower water tank plate and the lower forming mold are sequentially fixedly installed above the forming guide plate.

4. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 3, characterized in that: The step-forming component also includes an upper mold base, an air duct mold, a preforming mold, and multiple sets of preforming cylinders. The upper mold base is fixedly connected to the upper ends of multiple forming columns. The air duct mold is fixedly connected to the side of the upper mold base that is close to the lower forming mold. The preforming mold is slidably disposed inside the air duct mold. The multiple sets of preforming cylinders are all fixedly disposed above the upper mold base, and the telescopic ends of the multiple sets of preforming cylinders are all fixedly connected to the preforming mold.

5. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 1, characterized in that: The blister forming assembly also includes a housing, multiple sets of clamping cylinders and a pair of clamping rollers. The housing is fixedly installed inside the machine base, the tensioning roller is rotatably installed inside the housing, the pair of clamping cylinders are fixedly installed on the outside of the housing, the pair of clamping rollers are installed on the outside of the tensioning roller, and the pair of clamping rollers are rotatably connected to the extension and retraction ends of the multiple sets of clamping cylinders respectively.

6. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 1, characterized in that: The vibratory feeding component includes a vibratory plate, a pair of guide troughs, multiple sets of discharge cover plates, and a discharge sensor. The vibratory plate is positioned above the guide plate, and a pair of guide troughs are provided inside the vibratory plate. The pair of guide troughs are connected to the discharge channel. The multiple sets of discharge cover plates are fixedly positioned above the packing plate and are configured in conjunction with the multiple sets of guide plates. The discharge sensor is fixedly positioned below the vibratory plate and is configured corresponding to the discharge channel.

7. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 6, characterized in that: The vibratory feeding component also includes a fixed frame, a storage bin, a feeding cylinder, and a baffle plate. The fixed frame is fixedly installed above the vibratory plate, the storage bin is fixedly connected to the fixed frame, the feeding cylinder is fixedly installed below the fixed frame, the baffle plate is fixedly connected to the telescopic end of the feeding cylinder, and the baffle plate is configured to cooperate with the discharge port of the storage bin.

8. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 1, characterized in that: The vacuum cleaning component includes a cleaning hood and an extraction pipe. The cleaning hood is fixedly installed above the packing plate, and a filter screen is fixedly installed at the lower opening of the cleaning hood. The extraction pipe is fixedly installed above the cleaning hood.

9. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 1, characterized in that: The post-processing components include a dust cover, a limiting roller, a rotating frame, an anilox roller, an aluminum foil loading roller, a guide limiting roller, a drive housing, an embossing die, and a punching die. The dust cover is fixedly installed on one side of the machine base. The limiting roller is rotatably installed inside the dust cover. The rotating frame is rotatably installed inside the dust cover, and the anilox roller is rotatably connected to the side of the rotating frame close to the limiting roller.

10. The integrated blister packaging machine for three dosage forms in biopharmaceuticals according to claim 9, characterized in that: The aluminum foil loading roller is rotatably disposed inside the dust cover, and multiple sets of the guide and limiting rollers are also rotatably disposed inside the dust cover. The drive box base is fixedly disposed inside the dust cover, and the embossing die and the punching die are respectively fixedly disposed at both ends of the drive box base.

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