Lymphematopoietic pathological section high-throughput digital scanning and intelligent analysis device

Abstract

The invention relates to the technical field of pathological section scanning, and particularly discloses a lymphatic hematopoietic pathological section high-flux digital scanning and intelligent analysis device which comprises a lower shell, a base is arranged on the lower shell, and a collecting bin and a feeding bin are arranged on the two sides of the top of the base respectively. The collecting bin and the feeding bin are each provided with a sliding guide rail groove and a material opening. A plurality of groups of screw rod assemblies are mounted on the base, a scanning assembly is mounted in the middle of the plurality of groups of screw rod assemblies, and a camera is arranged at the bottom of the scanning assembly; a control assembly and a central fixing disc are mounted at the bottom of the camera on the base, and a plurality of clamping blocks are arranged on the central fixing disc; through a meshing transmission structure of the toothed plate and the first gear and a lifting mechanism of the stabilizing plate and the threaded rod, linkage control over the height of the scanning assembly and rotation of the rotating disc is achieved, the scanning focal length can be accurately adjusted according to pre-measured data, and the definition and consistency of scanning imaging are improved.

Description

Technical Field

[0001] This invention relates to the field of pathological slide scanning technology, and more specifically to a high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological slides. Background Technology

[0002] The diagnosis of lymphohematopoietic system diseases (such as lymphoma and leukemia) heavily relies on morphological observation and immunohistochemical analysis of pathological sections. Lymphoid tissue is characterized by extremely dense cells, fragile texture, and a tendency to wrinkle and exhibit staining differences, demanding extremely high section quality and scanning accuracy. With the development of digital pathology, high-throughput slide scanners have been gradually applied in clinical practice, but the following problems exist in practical use: First, existing scanning equipment lacks sufficient automation, mostly operating as stand-alone machines. Manual tasks such as slide loading, cleaning, and barcode entry are required, making it difficult to achieve fully automated processing from slide preparation to digital image. Pathologists need to intervene frequently, which is not only inefficient but also prone to introducing human error. Secondly, the scanning quality is limited by the sample condition. Lymphoid tissue sections often have problems such as wrinkles, folds, and local defocusing. Traditional vertical scanning methods are difficult to obtain complete and clear full-field images, resulting in a high rescan rate and affecting diagnostic efficiency. Furthermore, existing scanners have limited functionality and lack pre-processing capabilities. They cannot perform functions such as slide cleaning, thickness measurement, and pre-focusing before scanning. During the scanning process, defocusing problems caused by slide stains or thickness differences frequently occur. Furthermore, the existing equipment is disconnected from the subsequent intelligent analysis system. After scanning, images need to be manually exported and then imported into the analysis system, resulting in a fragmented process that makes it difficult to achieve real-time diagnostic feedback and automatic classification and storage. Summary of the Invention

[0003] In order to overcome the above-mentioned defects of the prior art, the present invention provides a high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections to solve the problems existing in the background art.

[0004] This invention provides the following technical solution: a high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological slides, comprising a lower outer shell, a base on the lower outer shell, a collection chamber and a feeding chamber on the top two sides of the base respectively, and sliding guide grooves and feeding ports on the collection chamber and the feeding chamber; multiple sets of screw assemblies are installed on the base, a scanning assembly is installed in the middle of the multiple sets of screw assemblies, and a camera is installed at the bottom of the scanning assembly; a control assembly and a central fixing plate are installed on the base below the camera, and multiple locking blocks are provided on the central fixing plate; a drive motor is installed at the bottom of the control assembly, and a second push rod is installed at the top of the control assembly.

[0005] Furthermore, a lifting push rod is installed inside the collection compartment to drive the storage tray to rise as a whole inside the collection compartment, achieving multi-layer stacking collection.

[0006] Furthermore, the control component consists of a rotating disk and a control arc plate. The control arc plate is mounted on the rotating disk via a connecting plate, and a toothed plate is installed on the outer side of the rotating disk. Two sets of sliding material grooves are opened on the top of the rotating disk. The two sets of sliding material grooves are distributed at an obtuse angle and are connected to the material inlet of the feeding bin or the collection bin before and after rotation, respectively. The second push rod consists of a hydraulic rod and a push plate. The height of the push plate is the same as that of the placement tray.

[0007] Furthermore, the tray includes a movable main frame with multiple feeding tines; the middle part of the movable main frame is a slide slot, in which a slide is installed; a first support point and a second support point are fixedly connected to the side of the movable main frame.

[0008] Furthermore, the screw assembly includes a threaded rod, on which a first gear is fixedly connected, and the first gear meshes with a gear plate; a stabilizing plate is mounted on the threaded rod, and multiple stabilizing plates are mounted together on the side of the scanning assembly.

[0009] Furthermore, the shelf includes a retractable main board, on which multiple sets of movable support rods are installed. Each set of movable support rods is hinged to the retractable main board, and each movable support rod has a movable slot, the position of which corresponds to the second fulcrum.

[0010] Furthermore, control contacts are installed on the front of the collection bin and the feeding bin. When the control arc plate rotates to align with the collection bin or the feeding bin, the end of the control arc plate contacts the control contacts, triggering the corresponding feeding, scanning or discharging program.

[0011] Furthermore, the rotating disk has multiple functional stations inside, including a cleaning station, a thickness measurement station, and a scanning station; the cleaning station is equipped with a miniature rotating brush to remove stains from the surface of the glass slide; the thickness measurement station is equipped with a laser displacement sensor to measure the height of the cover glass slide surface; and the scanning station is equipped with a miniature tilt motor, which can adjust the tilt angle of the glass slide within the range of 0-15°.

[0012] Furthermore, the control contact is a multi-functional electrical interface. When the control arc plate contacts the control contact, it supplies power to the active devices inside the rotating disk and transmits scanning parameters and status data.

[0013] The technical effects and advantages of this invention are as follows: 1. This invention, by incorporating a feeding bin, a rotating disk, and a collection bin, achieves fully automated operation of automatic feeding, transfer, scanning, and classified storage of glass slides, effectively solving the problems of manual intervention and low efficiency of existing equipment, and significantly improving the work efficiency of the pathology department.

[0014] 2. The present invention achieves linkage control between the height of the scanning assembly and the rotation of the rotating disk through a meshing transmission structure with a toothed plate and a first gear, and a lifting mechanism with a stabilizing plate and a threaded rod. This allows the scanning focal length to be precisely adjusted according to the predicted data, thereby improving the clarity and consistency of the scanning image. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0016] Figure 2 This is a diagram of the overall internal structure of the present invention.

[0017] Figure 3 For the present invention Figure 2 Schematic diagram of structure A in the middle.

[0018] Figure 4 This is a schematic diagram of the control component structure of the present invention.

[0019] Figure 5 This is a schematic diagram of the storage tray structure of the present invention.

[0020] Figure 6 This is a schematic diagram of the screw assembly structure of the present invention.

[0021] Figure 7 This is a schematic diagram of the shelf structure of the present invention.

[0022] The attached diagram is labeled as follows: 1. Lower outer shell; 101. Base; 102. Collection bin; 103. Feeding bin; 104. Sliding guide rail groove; 105. Feeding port; 2. Upper outer shell; 3. Shelf; 301. Retractable main board; 302. Movable support rod; 303. Movable slot; 4. Control assembly; 401. Rotary disk; 402. Sliding feed chute; 403. Control arc plate; 404. Gear plate; 5. Screw assembly; 501. Threaded rod; 502. First gear; 503. Stabilizing plate; 6. Scanning assembly; 7. Storage tray; 701. Moving main frame; 702. Feeding helical gear; 703. First fulcrum; 704. Second fulcrum; 705. Slide slot; 8. Control contact; 9. First push rod; 10. Second push rod; 11. Central fixing plate. Detailed Implementation

[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. In addition, the morphology of each structure described in the following embodiments is merely illustrative. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological slides involved in the present invention is not limited to the structures described in the following embodiments. All other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Reference Figure 1 and Figure 2 This invention provides a high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological slides, comprising a lower outer shell 1 and an upper outer shell 2. The lower outer shell 1 includes a base 101, with a collection chamber 102 and a feeding chamber 103 respectively located on the top two sides of the base 101. Both the collection chamber 102 and the feeding chamber 103 have sliding guide grooves 104 and feeding ports 105. The sliding guide grooves 104 on the collection chamber 102 and the feeding chamber 103 correspond to the first support point 703 and the second support point 704 of the placement tray 7, respectively. Multiple sets of screw assemblies 5 are mounted on the base 101, and a scanning assembly 6 is mounted in the middle of the screw assemblies 5. A high-resolution camera is located at the bottom of the scanning assembly 6. A control assembly 4 and a central fixing plate 11 are mounted on the base 101 below the camera, and the central fixing plate 11 has multiple locking blocks. A drive motor is mounted at the bottom of the control assembly 4, and a second push rod 10 is mounted at the top of the control assembly 4.

[0025] In this embodiment, it should be specifically noted that: a lifting push rod is installed inside the collection chamber 102, which is used to raise the entire tray 7 inside the collection chamber 102 to achieve multi-layer stacking collection, and can hold 50-100 slices at a time. The controller is electrically connected to the drive motor, scanning component 6 and lifting push rod, and is used to control the coordinated action of each mechanism according to the scanning progress.

[0026] Reference Figure 3 and Figure 4 The control component 4 consists of a rotating disk 401 and a control arc plate 403. The control arc plate 403 is mounted on the rotating disk 401 via a connecting plate, and a toothed plate 404 is mounted on the outer side of the rotating disk 401. Two sets of sliding material grooves 402 are provided on the top of the rotating disk 401, distributed at a 120° obtuse angle, and connected to the material inlet 105 of the loading bin 103 or the collection bin 102 before and after rotation. The second push rod 10 consists of a hydraulic rod and a push plate, the height of which is the same as that of the placement tray 7, and is used to push the placement tray 7 from the rotating disk 401 into the collection bin 102 after rotation.

[0027] In this embodiment, it should be specifically noted that control contacts 8 are installed on the front of the collection bin 102 and the loading bin 103. When the control arc plate 403 rotates to align with the collection bin 102 or the loading bin 103, the end of the control arc plate 403 contacts the control contact 8, triggering the corresponding loading, scanning, or unloading program. The control contact 8 integrates power contacts and data contacts, which, when in contact, supply power to the active devices in the rotating disk 401 and transmit scanning parameters and status data.

[0028] As a further optimization of the present invention, the rotating disk 401 has multiple functional stations inside. The first station is a cleaning station, equipped with a miniature rotating brush. When the slide passes by, the miniature rotating brush rotates to remove fingerprints, resin residue, and other stains from the surface of the cover glass. The second station is a thickness measurement station, equipped with a laser displacement sensor to measure the distance from the surface of the cover glass to a reference plane, generating the focal plane offset of the slide and transmitting it to the scanning component 6. The third station is a scanning station, equipped with a miniature tilt motor, which can precisely adjust the tilt angle of the slide within a range of 0-15°. This, combined with the scanning component 6, allows for multi-angle imaging of areas with wrinkles, acquiring image data from different angles for subsequent fusion processing.

[0029] Reference Figure 5 The storage tray 7 includes a movable main frame 701, which is equipped with multiple feeding tines 702. The feeding tines 702 allow the storage tray 7 to enter the central fixed plate 11 normally, where it is secured at all four corners by locking blocks. The central part of the movable main frame 701 is a slide groove 705, in which slides containing lymphatic tissue section information are installed. A first fulcrum 703 and a second fulcrum 704 are fixedly connected to the side of the movable main frame 701. The first fulcrum 703 and the second fulcrum 704 provide stability during movement and ensure stable guidance when the storage tray 7 moves within the collection chamber 102 or the loading chamber 103. This also allows the storage tray 7 to be removed horizontally when the storage rack 3 is taken out.

[0030] Reference Figure 6 The screw assembly 5 includes a threaded rod 501, on which a first gear 502 is fixedly connected. The first gear 502 meshes with a gear plate 404. A stabilizing plate 503 is mounted on the threaded rod 501. Multiple stabilizing plates 503 are mounted together on the side of the scanning assembly 6 to control the lifting and lowering of the scanning assembly 6. When the rotating disk 401 rotates, the gear plate 404 drives the first gear 502 to rotate, thereby causing the stabilizing plates 503 to move on the threaded rod 501, achieving precise adjustment of the height of the scanning assembly 6.

[0031] Reference Figure 7The shelf 3 includes a retractable main board 301, on which multiple sets of movable support rods 302 are mounted. Each set of movable support rods 302 is hinged to the retractable main board 301, and each movable support rod 302 has a movable slot 303, the position of which corresponds to the second fulcrum 704. The shelf 3 is used for batch transfer of the storage tray 7, making it convenient for operators to load multiple slices at once.

[0032] As a further optimization of the present invention, the control contact 8 is a multi-functional electrical interface, which integrates power contacts and data contacts. When the control arc plate 403 contacts the control contact 8, the power contact is turned on to supply power to the miniature rotating brush, laser displacement sensor and miniature tilt motor in the rotating disk 401; the data contact is turned on to transmit the thickness data measured by the laser displacement sensor and the focusing command of the scanning component.

[0033] The working principle and specific steps of this invention are as follows: The main problem solved by this embodiment is to achieve full automation of the lymphatic tissue sectioning process from automatic feeding to intelligent scanning through the multi-functional station design of the rotary disk and the electrical connection of the control contacts, and to solve the image quality problems caused by wrinkles and stains.

[0034] The specific steps are as follows: S1: Batch loading and feeding preparation: The operator places multiple trays 7 containing lymph tissue slices into the feeding bin 103 in batches via the rack 3. The pushing mechanism at the bottom of the feeding bin 103 pushes the bottommost tray 7 to the feeding port 105 to wait for loading. S2: Automatic feeding and positioning: The drive motor starts, causing the control component 4 to rotate clockwise. When the left end of the control arc plate 403 on the front of the rotating disk 401 contacts the control contact 8 on the front of the feeding bin 103, the feeding program is triggered. At this time, the sliding material groove 402 on the rotating disk 401 is precisely aligned with the material inlet 105 of the feeding bin 103, and the first push rod 9 pushes the placement tray 7 forward, so that it enters the central fixed plate 11 along the sliding material groove 402 and is fixed by the four corners of the clamping block, completing the feeding action; S3: Pre-processing and Measurement: After the tray 7 is fixed, the control component 4 continues to rotate, causing the glass slide to pass through each functional station in the rotating disk 401 in sequence. First, it passes through the cleaning station, where a micro rotating brush removes stains from the surface of the cover glass; then it passes through the thickness measurement station, where a laser displacement sensor measures the height of the cover glass and generates the focal plane offset. S4: Intelligent Scanning and Focusing: After preprocessing, the drive motor reverses, and the control component 4 rotates counterclockwise. During rotation, the toothed plate 404 meshes with the first gear 502, driving the threaded rod 501 to rotate, so that the stabilizing plate 503 and the scanning component 6 can precisely adjust their height according to the predicted focal plane offset, achieving fast and accurate focusing. When scanning to an area with wrinkles, the micro tilt motor starts, adjusting the tilt angle of the slide within the range of 0-15° to perform multi-angle imaging, ensuring clear and complete details of the cell nucleus; S5: Automatic Discharge and Collection: When the counterclockwise rotation reaches the endpoint, the right end of the control arc plate 403 on the front of the rotating disk 401 contacts the control contact 8 on the front of the collection bin 102, triggering the discharge program. The second push rod 10 is activated, and its push plate pushes the feeding helical tooth 702, causing the placement tray 7 to move out of the central fixed plate 11 and enter the collection bin 102 along the sliding material groove 402. The first fulcrum 703 and the second fulcrum 704 enter the sliding guide rail groove 104 to ensure smooth movement. The lifting push rod in the collection bin 102 pushes the placement tray 7 to different height positions according to the preset classification, realizing classified storage; S6: Cyclic operation: Repeat steps S2 to S5 above to achieve continuous, unmanned, large-batch automatic scanning of slices; The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections, comprising a lower outer shell (1), characterized in that: The lower outer shell (1) includes a base (101), and a collection bin (102) and a feeding bin (103) are respectively provided on the top two sides of the base (101). The collection bin (102) and the feeding bin (103) are both provided with sliding guide rail grooves (104) and feeding ports (105). Multiple sets of screw assemblies (5) are installed on the base (101), and a scanning assembly (6) is installed in the middle of the multiple sets of screw assemblies (5). A control assembly (4) and a central fixing plate (11) are installed on the base (101) below the scanning assembly (6). Multiple locking blocks are provided on the central fixing plate (11). A drive motor is installed at the bottom of the control assembly (4), and a second push rod (10) is installed at the top of the control assembly (4).

2. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 1, characterized in that: The control component (4) consists of a rotating disk (401) and a control arc plate (403). The control arc plate (403) is mounted on the rotating disk (401) via a connecting plate. A toothed plate (404) is installed on the outer side of the rotating disk (401). Two sets of sliding material grooves (402) are provided on the top of the rotating disk (401). The two sets of sliding material grooves (402) are distributed at an obtuse angle and are connected to the material inlet (105) of the feeding bin (103) or the collecting bin (102) before and after rotation.

3. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 2, characterized in that: The rotating disk (401) has multiple functional stations inside, including a cleaning station, a thickness measurement station and a scanning station; a miniature rotating brush is installed at the cleaning station to clean the surface when the glass slide enters; a laser displacement sensor is installed at the thickness measurement station; and a miniature tilting motor is installed at the scanning station.

4. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 1, characterized in that: The front of the collection bin (102) and the feeding bin (103) are equipped with control contacts (8). When the control arc plate (403) is rotated to align with the collection bin (102) or the feeding bin (103), the end of the control arc plate (403) contacts the control contact (8) to trigger the corresponding feeding, scanning or discharging program.

5. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 4, characterized in that: The control contact (8) is a multi-functional electrical interface that integrates power contacts and data contacts, used to power the active devices in the rotating disk (401) and transmit data.

6. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 1, characterized in that: The screw assembly (5) includes a threaded rod (501), on which a first gear (502) is fixedly connected, and the first gear (502) meshes with a gear plate (404); a stabilizing plate (503) is installed on the threaded rod (501), and multiple stabilizing plates (503) are installed together on the side of the scanning assembly (6).

7. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 1, characterized in that: It also includes a storage tray (7), which includes a movable main frame (701), a plurality of feeding slant teeth (702) on the movable main frame (701), a glass slide groove (705) in the middle of the movable main frame (701), and a first support point (703) and a second support point (704) fixedly connected to the side of the movable main frame (701).

8. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 1, characterized in that: It also includes a shelf (3), which includes a retractable main board (301). Multiple sets of movable support rods (302) are installed on the retractable main board (301). Each set of movable support rods (302) is hinged to the retractable main board (301), and each movable support rod (302) has a movable slot (303).

9. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 1, characterized in that: The collection compartment (102) is equipped with a lifting push rod, which is used to drive the storage tray (7) to collect and classify the multi-layer stack inside the collection compartment (102).

10. The high-throughput digital scanning and intelligent analysis device for lymphohematopoietic pathological sections according to claim 1, characterized in that: The scanning component (6) has a built-in analysis module for automatically performing cell detection, classification and counting.

Images