Traditional Chinese medicine composition for treating eczema

Abstract

The invention discloses a traditional Chinese medicine composition for treating eczema, which is prepared from the following raw material components in parts by weight: 15-30 parts of garden burnet, 10-15 parts of radix sophorae flavescentis, 3-10 parts of coptis chinensis, 3-9 parts of fructus evodiae, 10-15 parts of cortex dictamni, 6-15 parts of fructus cnidii, 6-12 parts of angelica sinensis and 10-30 parts of radix rehmanniae recen. The medicinal materials in the formula interact with one another, the fructus evodiae can be used for assisting bitter cold and warming yang and drying dampness, the angelica sinensis and the radix rehmanniae recen can be used for regulating qi, blood, yin and yang, so that the medicine property of the whole formula tends to be mild, the effects of the medicinal materials are synergistically exerted, and the aim of treating eczema is jointly achieved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and more specifically to a traditional Chinese medicine composition for treating eczema. Background Technology

[0002] Eczema is a common inflammatory skin disease characterized by polymorphic rashes, intense itching, recurrent flare-ups, and a tendency to become chronic. In recent years, influenced by factors such as environmental changes and lifestyle alterations, the global prevalence of eczema has continued to rise, with a particularly high incidence among children and adolescents, making it one of the chronic diseases that seriously affect public health.

[0003] From the perspective of Traditional Chinese Medicine (TCM), the pathogenesis of eczema is closely related to "dampness, heat, wind, and deficiency." In the acute phase, it is often caused by external wind-evil combined with internal damp-heat, resulting in the accumulation of wind, dampness, and heat in the skin. In the chronic phase, it is caused by prolonged illness depleting yin and blood, leading to blood deficiency and dryness, and malnourishment of the skin. Spleen deficiency and dampness accumulation are important internal foundations of eczema. When the spleen fails to function properly, dampness is generated internally, which stagnates and transforms into heat, manifesting on the skin along the meridians. Therefore, TCM treatment of eczema generally follows the basic principles of clearing heat and dampness, dispelling wind and relieving itching, and nourishing blood and moisturizing dryness, while also addressing both the symptoms and the root cause.

[0004] Fu'ai's Yushen Cream is composed of Sanguisorba officinalis, Sophora flavescens, Coptis chinensis, and Evodia rutaecarpa in a 4:3:2:1 ratio. Its medicinal properties are bitter, cold, pungent, and astringent, with mild, non-toxic, and non-irritating effects in clearing heat and detoxifying, drying dampness and relieving itching. However, this formula is primarily used to treat infantile eczema. The pathogenesis of pediatric eczema includes: congenital deficiency, spleen dysfunction, damp-heat and food stagnation; or excessive consumption of rich and greasy foods, damaging the spleen and stomach, leading to damp-heat accumulation and overflowing to the skin; or congenital malnutrition, insufficient qi and blood, blood depletion and dryness of body fluids, resulting in malnourished skin. This four-herb combination is insufficiently targeted at chronic blood deficiency and wind-dryness type eczema. Patients with chronic eczema often have yin and blood deficiency and malnourishment of the skin. Long-term use of this combination may further deplete yin and blood due to the bitter and cold nature of the herbs, exacerbating the blood deficiency and wind-dryness syndrome, leading to a prolonged illness. Furthermore, some patients may experience adverse reactions such as stomach discomfort and loss of appetite after use. Summary of the Invention

[0005] In view of this, the present invention provides a traditional Chinese medicine composition for treating eczema, which has a wider range of indications and fewer side effects.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A traditional Chinese medicine composition for treating eczema, comprising the following raw materials in parts by weight: 15-30 parts of Sanguisorba officinalis, 10-15 parts of Sophora flavescens, 3-10 parts of Coptis chinensis, 3-9 parts of Evodia rutaecarpa, 10-15 parts of Dictamnus dasycarpus, 6-15 parts of Cnidium monnieri, 6-12 parts of Angelica sinensis, and 10-30 parts of Rehmannia glutinosa.

[0008] Preferably, the above-mentioned traditional Chinese medicine composition comprises the following raw material components by weight: 20 parts of Sanguisorba officinalis, 15 parts of Sophora flavescens, 10 parts of Coptis chinensis, 5 parts of Evodia rutaecarpa, 15 parts of Dictamnus dasycarpus, 12 parts of Cnidium monnieri, 12 parts of Angelica sinensis, and 15 parts of Rehmannia glutinosa.

[0009] Preferably, the above-mentioned traditional Chinese medicine composition comprises the following raw material components by weight: 20g of Sanguisorba officinalis, 12g of Sophora flavescens, 6g of Coptis chinensis, 6g of Evodia rutaecarpa, 12g of Dictamnus dasycarpus, 10g of Cnidium monnieri, 10g of Angelica sinensis, and 15g of Rehmannia glutinosa.

[0010] Preferably, the above-mentioned traditional Chinese medicine composition comprises the following raw material components by weight: 25g of Sanguisorba officinalis, 15g of Sophora flavescens, 10g of Coptis chinensis, 5g of Evodia rutaecarpa, 15g of Dictamnus dasycarpus, 12g of Cnidium monnieri, 12g of Angelica sinensis, and 20g of Rehmannia glutinosa.

[0011] Preferably, the above-mentioned traditional Chinese medicine composition comprises the following raw material components by weight: 15g of Sanguisorba officinalis, 10g of Sophora flavescens, 5g of Coptis chinensis, 8g of Evodia rutaecarpa, 10g of Dictamnus dasycarpus, 8g of Cnidium monnieri, 12g of Angelica sinensis, and 25g of Rehmannia glutinosa.

[0012] Preferably, the above-mentioned traditional Chinese medicine composition comprises the following raw material components by weight: 30g of Sanguisorba officinalis, 15g of Sophora flavescens, 8g of Coptis chinensis, 5g of Evodia rutaecarpa, 15g of Dictamnus dasycarpus, 15g of Cnidium monnieri, 10g of Angelica sinensis, and 15g of Rehmannia glutinosa.

[0013] The preparation method of the above-mentioned traditional Chinese medicine composition includes the following steps: drying and storing, grinding into fine powder and sealing for later use; when ready for use, mixing with an oil-in-water cream base to form a 15%~30% paste dosage form.

[0014] The beneficial effects of this invention are: The role of each ingredient in the formula Sanguisorba officinalis: Cold in nature, sour, bitter, and astringent in taste, it enters the liver and large intestine meridians. It possesses the effects of clearing heat and detoxifying, cooling the blood and stopping bleeding. In the formula of this invention, its anti-inflammatory and antibacterial effects are further enhanced, effectively relieving skin redness and itching caused by eczema, and having a good astringent effect on the exudative and erosive symptoms of acute eczema. Modern research shows that the tannins, saponins, and other components in Sanguisorba officinalis can inhibit the release of inflammatory mediators and reduce skin inflammatory reactions.

[0015] Sophora flavescens: Cold in nature and bitter in taste, it enters the heart, liver, stomach, large intestine, and bladder meridians. It has the effects of clearing heat and drying dampness, killing parasites and relieving itching. Targeting the damp-heat pathogenesis of eczema, it can deeply clear damp-heat pathogens from the body, relieving skin erythema, papules, and severe itching. In addition, Sophora flavescens also has a certain anti-allergic effect, which can reduce the recurrence of eczema.

[0016] Coptis chinensis: Cold in nature, bitter in taste, and enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. Its powerful heat-clearing, dampness-drying, fire-purging, and detoxifying effects are highlighted in the formula, focusing on clearing heat toxins from the body of eczema patients and improving symptoms such as burning and redness caused by heat toxins. The berberine component in Coptis chinensis has significant antibacterial and anti-inflammatory effects, effectively inhibiting harmful bacteria on the skin surface.

[0017] Evodia rutaecarpa: Hot in nature, pungent and bitter in taste, slightly toxic, and enters the liver, spleen, stomach, and kidney meridians. In the original formula, it acts as a counteracting agent, restraining the cold nature of other bitter and cold herbs and preventing them from harming the stomach. After improvement, its warming, dispersing, dampness-drying, and pain-relieving effects further assist in regulating the patient's constitution. For cold-dampness type eczema or eczema caused by spleen and stomach deficiency, it can warm and transform cold and dampness, restoring the normal digestive function of the spleen and stomach.

[0018] Dictamnus dasycarpus root bark: Cold in nature, bitter in taste, and enters the spleen, stomach, and bladder meridians. It excels at clearing heat and drying dampness, dispelling wind and detoxifying, making it an excellent medicine for treating itchy skin. It can directly reach the skin, clearing away wind-dampness and heat from the skin surface, quickly relieving itching symptoms caused by eczema, and also has a repairing effect on skin damage and exudation caused by eczema.

[0019] Cnidium monnieri: Warm in nature, pungent and bitter in taste, slightly toxic, and enters the kidney meridian. It possesses the effects of drying dampness and dispelling wind, killing parasites and relieving itching, and warming the kidneys and strengthening yang. In formulas, Cnidium monnieri can enhance the effect of drying dampness and relieving itching, alleviating the itching discomfort of eczema, and can also warm and tonify kidney yang, adjusting the patient's physical condition. It has a good effect on improving recurrent flare-ups of chronic eczema caused by insufficient yang qi and lingering dampness.

[0020] Angelica sinensis: Warm in nature, sweet and pungent in taste, it enters the liver, heart, and spleen meridians. It has the effects of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and promoting bowel movements. In this formula, Angelica sinensis mainly plays the role of nourishing and promoting blood circulation, following the traditional Chinese medicine theory of "treating wind by first treating blood, for when blood flows smoothly, wind will naturally subside." By nourishing blood and moisturizing dryness, it improves the symptoms of dry and flaky skin in eczema patients, while also promoting blood circulation in the skin and accelerating the repair of eczema lesions.

[0021] Rehmannia glutinosa: Cold in nature, sweet in taste, and enters the heart, liver, and kidney meridians. It can clear heat and cool the blood, nourish yin and generate fluids. For eczema patients with symptoms such as dry skin and dry mouth caused by heat toxin damaging yin, Rehmannia glutinosa can nourish yin and clear heat, replenish the body's yin fluids, prevent heat toxins from further damaging yin fluids, and maintain the body's yin-yang balance.

[0022] The pairing of ruler, minister, assistant, and envoy Principal herbs: Sanguisorba officinalis, Coptis chinensis With its effects of clearing heat and detoxifying, cooling blood and astringing, Sanguisorba officinalis directly targets the core pathogenesis of eczema caused by damp-heat and heat toxins accumulating in the skin, quickly relieving acute symptoms such as skin redness, swelling and exudation; Coptis chinensis powerfully clears heat toxins from the body, complementing Sanguisorba officinalis to jointly eliminate the main pathogenic factors that cause eczema. The two are the principal herbs and occupy the dominant position in the formula.

[0023] Assistant herbs: Sophora flavescens, Dictamnus dasycarpus root bark Sophora flavescens clears heat and dries dampness, assisting the principal herb in deeply clearing damp-heat from the body, thus cutting off the root cause of eczema. Dictamnus dasycarpus root bark dispels wind, detoxifies, and relieves itching, assisting the principal herb in alleviating skin symptoms and reducing patient suffering. Sophora flavescens and Dictamnus dasycarpus root bark work internally and externally, enhancing the therapeutic efficacy of the principal herb, thus serving as assistant herbs.

[0024] Adjuvant herbs: Cnidium monnieri, Angelica sinensis, Rehmannia glutinosa, Evodia rutaecarpa Cnidium monnieri dries dampness, relieves itching, warms the kidneys, and strengthens yang. On the one hand, it assists the principal and assistant herbs in enhancing the effect of drying dampness and relieving itching, and on the other hand, it adjusts the patient's constitution and prevents eczema recurrence. Angelica sinensis nourishes blood and promotes blood circulation, while Rehmannia glutinosa clears heat and nourishes yin. Both of them target the symptoms of blood deficiency and yin deficiency that occur in the later stages of eczema or chronic eczema, and play a role in nourishing blood, moisturizing dryness, nourishing yin, and clearing heat, thus improving dry skin and peeling. Evodia rutaecarpa acts as a counteracting agent to restrain the cold nature of the principal and assistant herbs, preventing bitter and cold herbs from damaging the stomach. At the same time, it warms and transforms cold and dampness, taking into account patients with spleen and stomach deficiency and cold type eczema. All four herbs work together as adjuvant herbs.

[0025] Guiding agent: There is no single, clearly defined guiding agent; the drugs are used in harmony with each other. The various medicinal materials in the formula of this invention interact with each other. Evodia rutaecarpa can both counteract the bitter and cold nature of the herbs and warm the yang and dry dampness. Angelica sinensis and Rehmannia glutinosa can harmonize qi, blood, yin and yang, making the overall medicinal properties of the formula more balanced. The effects of each medicinal material can be synergistically exerted to achieve the purpose of treating eczema. Detailed Implementation

[0026] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] Example 1 20g of Sanguisorba officinalis, 15g of Sophora flavescens, 10g of Coptis chinensis, 5g of Evodia rutaecarpa, 15g of Dictamnus dasycarpus, 12g of Cnidium monnieri, 12g of Angelica sinensis, and 15g of Rehmannia glutinosa.

[0028] Example 2 25g of Sanguisorba officinalis, 15g of Sophora flavescens, 10g of Coptis chinensis, 5g of Evodia rutaecarpa, 15g of Dictamnus dasycarpus, 12g of Cnidium monnieri, 12g of Angelica sinensis, and 20g of Rehmannia glutinosa.

[0029] Example 3 Sanguisorba officinalis 15g, Sophora flavescens 10g, Coptis chinensis 5g, Evodia rutaecarpa 8g, Dictamnus dasycarpus 10g, Cnidium monnieri 8g, Angelica sinensis 12g, Rehmannia glutinosa 25g Example 4 Sanguisorba officinalis 30g, Sophora flavescens 15g, Coptis chinensis 8g, Evodia rutaecarpa 5g, Dictamnus dasycarpus 15g, Cnidium monnieri 15g, Angelica sinensis 10g, Rehmannia glutinosa 15g Example 5: 20g of Sanguisorba officinalis, 12g of Sophora flavescens, 6g of Coptis chinensis, 6g of Evodia rutaecarpa, 12g of Dictamnus dasycarpus, 10g of Cnidium monnieri, 10g of Angelica sinensis, and 15g of Rehmannia glutinosa.

[0030] Example 6 The preparation method of the formulations in Examples 1-5 includes the following steps: Dry all raw materials, grind them into a fine powder and pass them through a 100-mesh sieve; mix them with an oil-in-water emulsion base (Ouyangxue oil-in-water moisturizing skin care snow cream) to make a 15% paste formulation.

[0031] Test case Experiment 1: Animal Experiment Test drug: 15% oil-in-water ointment paste prepared according to the formulations of Examples 1-5 in Example 6 of this invention (labeled as test groups 1-5 respectively).

[0032] Control drugs: Positive control drug (commercially available brand of compound dexamethasone cream); negative control (equal amount of base cream); model control group (modeling only, no treatment).

[0033] Laboratory animals: Healthy male BALB / c mice, SPF grade, weighing 18-22g, acclimatized for one week.

[0034] Main reagents and instruments: 2,4-dinitrochlorobenzene (DNCB), multi-functional microplate reader, skin moisture loss tester (TEWL), skin pH meter.

[0035] Experimental methods and results: (1) Establishment and evaluation of a mouse model of chronic eczema: A chronic eczema model was induced in mice using repeated topical application of DNCB. After successful modeling, mice were randomly divided into a model control group, a negative control group, a positive control group, and experimental groups 1-5, with 10 mice in each group. The appropriate medication was applied to the affected area once daily for 14 consecutive days.

[0036] Observation indicators: Skin lesion severity score: The severity of erythema, edema, epidermal abrasion, and lichenification of the skin lesions on the ears or back of mice were scored twice a week.

[0037] Itching behavior record: Observe and record the number of times the mice scratch.

[0038] Skin barrier function testing: After treatment, transepidermal water loss (TEWL) and skin pH were measured.

[0039] result Compared with the model group and the negative control group, experimental groups 1-5 all significantly reduced the severity score of skin lesions (P<0.01). Among them, experimental group 2 was particularly effective in reducing acute inflammatory markers such as erythema and edema, and was comparable to the positive control group.

[0040] All experimental groups showed a significant reduction in the number of times mice scratched (P<0.01), indicating that they had a good antipruritic effect.

[0041] After treatment, the TEWL values ​​in each experimental group were significantly lower than those in the model group, and the skin pH value tended to normalize, indicating that the composition of the present invention can effectively repair damaged skin barrier function.

[0042] (2) Preliminary study on anti-inflammatory and immunomodulatory mechanisms: Mouse skin lesions were homogenized, and the levels of inflammatory factors (such as TNF-α, IL-4, IL-13, and IFN-γ) were detected. The results showed that the levels of pro-inflammatory factors in the skin lesions of the experimental group were significantly lower than those in the model group, indicating that the herbal composition of this invention can exert its therapeutic effect by inhibiting Th2-type immune responses and reducing the release of inflammatory mediators.

[0043] Experiment 2, Clinical Trial 1. Research Design: A randomized, double-blind, positive-drug parallel-controlled trial was conducted. A total of 120 patients with acute and chronic eczema who met the diagnostic criteria were included.

[0044] 2. Experimental grouping and methods: Treatment group (60 cases): The 15% paste prepared according to Example 1 (general type) of the present invention was applied topically to the affected area twice a day.

[0045] Control group (60 cases): Used a well-known commercially available Chinese herbal eczema cream (without hormones), in the same way as the treatment group.

[0046] The treatment course was 4 weeks, and follow-up was conducted at weeks 0, 2, and 4 of treatment.

[0047] 3. Evaluation Criteria and Results: The main efficacy indicator is the EASI (Eczema Area and Severity Index) score.

[0048] Secondary efficacy endpoints: patient visual analog scale (VAS) score for pruritus, dermatology quality of life index (DLQI), comparison of skin lesion photos, and overall patient satisfaction.

[0049] result After 4 weeks of treatment, the overall effective rate in the treatment group was 91.7%, significantly higher than the 76.7% in the control group (P<0.05).

[0050] In terms of EASI score improvement rate and VAS score reduction, the treatment group showed a trend of being superior to the control group from week 2 onwards (P<0.05).

[0051] The treatment group also outperformed the control group in improving DLQI sub-indicators such as sleep and daily activity limitation.

[0052] Typical case images show that the erythema, papules, infiltration, and lichenification of the skin lesions in the treatment group resolved more quickly and thoroughly. All patients completed the trial without any dropouts.

[0053] 4. Safety Assessment: During the 4-week trial, only 3 cases of mild local irritation (transient burning sensation, which resolved spontaneously without treatment) were reported in the treatment group, and no systemic adverse reactions occurred. Clinical trials demonstrate that the herbal composition of this invention is effective and safe in treating eczema.

[0054] Experiment 3: Toxicological Experiment 1. Acute toxicity test: Skin irritation test: A single-dose test was conducted on intact and broken skin of rabbits. A paste equivalent to 50 times the human clinical dose (Example 1 of this invention) was applied and observed for 72 hours. Results showed no irritation reactions such as erythema or edema on the animal skin, indicating that this product has extremely low topical skin irritation.

[0055] Skin sensitization test (guinea pig maximal test): Sensitization and challenge were performed according to standard methods. Result interpretation: No obvious allergic reactions were observed in any guinea pigs, indicating a low risk of sensitization by this product.

[0056] 2. Long-term toxicity testing SD rats were selected and divided into a blank control group (matrix) and low-, medium-, and high-dose drug groups (5, 10, and 20 times the clinically equivalent dose, respectively). The drug was administered once daily through intact skin for 90 consecutive days. The animals' general condition, body weight, hematological and blood biochemical parameters were observed, and major organs were harvested for pathological examination.

[0057] Results: Compared with the control group, no statistically significant abnormalities were observed in the behavior, body weight, food intake, blood routine tests, and liver and kidney function (ALT, AST, BUN, Cr) of rats in each drug-treated group (P>0.05). Pathological examination of important organs (heart, liver, spleen, lungs, kidneys, and skin) also revealed no specific pathological changes related to drug toxicity. No delayed toxic reactions were observed during the two-week observation period after drug withdrawal.

[0058] The aforementioned animal experiments, clinical trials, and toxicological studies have fully verified, from multiple perspectives including efficacy, safety, and mechanism of action, that the present invention, "a traditional Chinese medicine composition for treating eczema," has a clear therapeutic effect and reliable safety.

[0059] Existing technology (Yushen Cream) mainly targets the damp-heat and food stagnation pathogenesis of infantile eczema. This invention, by adding Dictamnus dasycarpus root bark, Cnidium monnieri fruit, Angelica sinensis root, and Rehmannia glutinosa root, makes the formula more comprehensive in its effects: it not only clears heat and dries dampness (for the acute phase), but also nourishes blood, moisturizes dryness, dispels wind, and relieves itching, making it more targeted at the blood deficiency and wind-dryness syndrome of chronic eczema.

[0060] By using Angelica sinensis and Rehmannia glutinosa to nourish yin and blood, and harmonizing the bitter and cold properties of Coptis chinensis and Sophora flavescens, the potential for long-term use to cause spleen and stomach discomfort is reduced; Evodia rutaecarpa further protects the spleen and stomach through its antagonistic effect. It has a wider range of indications, not only suitable for infants, but also showing good efficacy for patients with damp-heat, physical weakness accompanied by damp-heat, and blood deficiency with wind-dryness.

[0061] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. Similar or identical parts between embodiments can be referred to interchangeably. For the apparatus disclosed in the embodiments, since they correspond to the methods disclosed in the embodiments, the description is relatively simple; relevant parts can be referred to the method section.

[0062] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine composition for treating eczema, characterized in that, By weight, it consists of the following raw materials: 15-30 parts of Sanguisorba officinalis, 10-15 parts of Sophora flavescens, 3-10 parts of Coptis chinensis, 3-9 parts of Evodia rutaecarpa, 10-15 parts of Dictamnus dasycarpus, 6-15 parts of Cnidium monnieri, 6-12 parts of Angelica sinensis, and 10-30 parts of Rehmannia glutinosa.

2. The traditional Chinese medicine composition for treating eczema according to claim 1, characterized in that, By weight, it consists of the following raw materials: 20 parts of Sanguisorba officinalis, 15 parts of Sophora flavescens, 10 parts of Coptis chinensis, 5 parts of Evodia rutaecarpa, 15 parts of Dictamnus dasycarpus, 12 parts of Cnidium monnieri, 12 parts of Angelica sinensis, and 15 parts of Rehmannia glutinosa.

3. The traditional Chinese medicine composition for treating eczema according to claim 1, characterized in that, By weight, it consists of the following raw materials: 20g of Sanguisorba officinalis, 12g of Sophora flavescens, 6g of Coptis chinensis, 6g of Evodia rutaecarpa, 12g of Dictamnus dasycarpus, 10g of Cnidium monnieri, 10g of Angelica sinensis, and 15g of Rehmannia glutinosa.

4. The traditional Chinese medicine composition for treating eczema according to claim 1, characterized in that, By weight, it consists of the following raw materials: 25g of Sanguisorba officinalis, 15g of Sophora flavescens, 10g of Coptis chinensis, 5g of Evodia rutaecarpa, 15g of Dictamnus dasycarpus, 12g of Cnidium monnieri, 12g of Angelica sinensis, and 20g of Rehmannia glutinosa.

5. The traditional Chinese medicine composition for treating eczema according to claim 1, characterized in that, By weight, it consists of the following raw materials: 15g of Sanguisorba officinalis, 10g of Sophora flavescens, 5g of Coptis chinensis, 8g of Evodia rutaecarpa, 10g of Dictamnus dasycarpus, 8g of Cnidium monnieri, 12g of Angelica sinensis, and 25g of Rehmannia glutinosa.

6. The traditional Chinese medicine composition for treating eczema according to claim 1, characterized in that, By weight, it consists of the following raw materials: Sanguisorba officinalis 30g, Sophora flavescens 15g, Coptis chinensis 8g, Evodia rutaecarpa 5g, Dictamnus dasycarpus 15g, Cnidium monnieri 15g, Angelica sinensis 10g, and Rehmannia glutinosa 15g.