Traditional Chinese medicine composition for treating vitiligo and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating vitiligo and a preparation method thereof, and relates to the technical field of preparation of traditional Chinese medicines for treating vitiligo. The traditional Chinese medicine composition is divided into an external composition and an internal composition, the external composition is prepared from nux vomica, cantharides, walnut skin, green persimmon, green fig, plant soot and red garlic according to a specific weight ratio, and the internal composition is prepared from rye, black beans, black sesame, polygonum multiflorum and fructus psoraleae according to a specific weight ratio. The external composition is fermented in a dark place and then decocted into paste, and the oral composition is fried and then ground into powder. Through the combination of external use and oral administration, the synergistic effect of the traditional Chinese medicinal materials is fully exerted, the leucoderma symptom of a leucoderma patient can be effectively improved, the medicinal materials are wide in source, the preparation process is simple, and the traditional Chinese medicine composition is suitable for being popularized and applied in clinical and daily treatment.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology for treating vitiligo, specifically to a traditional Chinese medicine composition for treating vitiligo and its preparation method. Background Technology

[0002] Vitiligo is a common acquired skin and mucous membrane disease characterized by loss of pigmentation. It is non-contagious, and its pathogenesis is not fully understood, but it is generally believed to be related to multiple factors, including genetics, autoimmunity, oxidative stress, and neuropsychiatric factors. The main clinical manifestation is the appearance of one or more white patches of varying sizes on the skin. These white patches can occur anywhere on the body, but are most common in exposed, friction-prone, and folded areas such as the face, neck, back of the hands, wrists, forearms, and lumbosacral region. Usually, there are no subjective symptoms, but a very small number of patients may experience mild itching in the early and progressive stages of the disease.

[0003] As the condition progresses, the area and number of white patches in vitiligo patients may gradually increase, severely affecting their appearance and leading to negative psychological states such as anxiety and depression, thus reducing their quality of life. Furthermore, vitiligo may occur concurrently with other systemic diseases, such as hyperthyroidism, hypothyroidism, autoimmune polygland syndrome, diabetes, and alopecia areata, further exacerbating the patient's physical burden.

[0004] Currently, clinical treatments for vitiligo mainly include drug therapy, phototherapy, hormone therapy, and small-area skin grafting. Drug therapy often uses topical corticosteroids and calcineurin inhibitors, but long-term use may cause adverse reactions such as skin atrophy and telangiectasia. Phototherapy mainly promotes melanocyte regeneration through ultraviolet radiation, but the treatment cycle is long, and some patients are not sensitive to phototherapy. Hormone therapy is suitable for patients with progressive vitiligo, controlling disease progression through oral or injectable corticosteroids, but long-term use may lead to systemic side effects such as elevated blood sugar and osteoporosis. Small-area skin grafting is suitable for patients in the stable phase with small lesions, but the surgery is invasive, and problems such as uneven pigmentation and graft failure may occur after transplantation. Because of the differences in disease type (such as segmental and non-segmental), severity of disease, location of disease, and individual constitution among different patients, existing treatment methods are difficult to effectively treat all patients, and some treatment methods have problems such as large side effects, long treatment cycles, and high costs.

[0005] Therefore, developing a drug for treating vitiligo that is effective, safe, easy to prepare, and inexpensive has become an urgent need in the medical field. Summary of the Invention (a) Technical problems to be solved

[0006] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine composition for treating vitiligo and its preparation method. This traditional Chinese medicine composition combines external and internal application, which can effectively improve the symptoms of vitiligo in patients. Moreover, the medicinal materials are widely available, the preparation process is simple, and the use is safe, thus solving the problems of large side effects and unstable efficacy of existing treatment methods.

[0007] To achieve the above objectives, the present invention provides the following technical solution: A traditional Chinese medicine composition for treating vitiligo, comprising a topical composition and an oral composition; The external application composition consists of the following raw materials in parts by weight: 2-4 parts of nux vomica, 2-4 parts of blister beetle, 480-520 parts of walnut shell, 240-260 parts of green persimmon, 90-110 parts of green fig, 280-320 parts of herbal ash, and 70-90 parts of red garlic. The oral composition consists of the following raw materials in parts by weight: 1900-2100 parts of rye, 900-1100 parts of black beans, 900-1100 parts of black sesame seeds, 240-260 parts of Polygonum multiflorum, and 140-160 parts of Psoralea corylifolia.

[0008] Furthermore, it includes topical compositions and oral compositions; The topical composition consists of the following raw materials in parts by weight: 3 parts nux vomica, 3 parts blister beetle, 500 parts walnut peel, 250 parts green persimmon, 100 parts green fig, 300 parts cypermethrin, and 80 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 2000 parts rye, 1000 parts black beans, 1000 parts black sesame seeds, 250 parts Polygonum multiflorum, and 150 parts Psoralea corylifolia.

[0009] Furthermore, it includes topical compositions and oral compositions; The external application composition consists of the following raw materials in parts by weight: 2 parts nux vomica, 2 parts blister beetle, 480 parts walnut peel, 240 parts green persimmon, 90 parts green fig, 280 parts cypermethrin, and 70 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 1900 parts rye, 900 parts black beans, 900 parts black sesame seeds, 240 parts Polygonum multiflorum, and 140 parts Psoralea corylifolia.

[0010] Furthermore, it includes topical compositions and oral compositions; The topical composition consists of the following raw materials in parts by weight: 4 parts nux vomica, 4 parts blister beetle, 520 parts walnut peel, 260 parts green persimmon, 110 parts green fig, 320 parts cypermethrin, and 90 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 2100 parts rye, 1100 parts black beans, 1100 parts black sesame seeds, 260 parts Polygonum multiflorum, and 160 parts Psoralea corylifolia.

[0011] Furthermore, the preparation method of the traditional Chinese medicine composition for treating vitiligo includes the following steps: Step S1. Preparation of the topical composition ① Weigh out the following ingredients by weight: nux vomica, blister beetle, walnut shell, green persimmon, green fig, cypermethrin, and red garlic. Remove the seed coat from the nux vomica, remove the legs and wings from the blister beetle, select fresh walnut shells that are free of mold, remove the pits from the green persimmon and green fig, and peel the red garlic. Wash all the pre-treated ingredients with purified water 2-3 times to remove the mud and impurities on the surface, and then drain the surface water. ② Place the drained raw materials into a sealed ceramic or glass container. The container should be disinfected with 75% alcohol and dried beforehand. Then place the container in a dark, dry environment with the ambient temperature controlled at 15-25℃ and the relative humidity controlled at 50-60%. Ferment for 100 days. ③ After fermentation, transfer all the raw materials and fermentation liquid from the container to an iron pot, add 2-3 times the total weight of the raw materials in purified water, stir well, heat over high heat until boiling, stirring constantly to prevent the raw materials from sticking to the pot, then reduce to low heat and simmer for 2-3 hours, stirring every 15-20 minutes until the material becomes a thick paste that can drip naturally without spreading when lifted with a spoon. Stop heating, transfer the external Chinese medicine paste to a clean container, cool to room temperature to obtain the external Chinese medicine paste, then seal and store in a cool place. The shelf life is 30-45 days. Step S2. Preparation of the oral composition ① Weigh out the rye, black beans, black sesame seeds, Polygonum multiflorum and Psoralea corylifolia by weight. First, remove impurities such as stones, broken pieces and weeds from the raw materials by screening. Then, wash the screened raw materials twice with pure water to remove surface dust and dirt. After washing, place them in a ventilated place to dry the surface moisture to avoid excessive moisture causing them to burn during subsequent stir-frying. ② Place the dried ingredients into a clean iron pot. Preheat the pot over low heat for 1-2 minutes, then turn to medium heat and stir-fry. Stir-fry the ingredients constantly with a spatula to ensure even heating. The black wheat, black beans, and black sesame seeds should be stir-fried until they turn slightly yellow and feel plump when rubbed with your hands, with a slight aroma. The Polygonum multiflorum and Psoralea corylifolia should be stir-fried until their surface color changes from light brown to dark brown, and they become slightly brittle and not easily broken. During the stir-frying process, closely observe the color and state of the ingredients to avoid burning. If any parts are burnt, turn off the heat immediately and remove the burnt parts. ③ Transfer the cooked raw materials to a clean tray and let them cool to room temperature to prevent residual heat from causing them to burn. Once the raw materials have completely cooled, grind them in a traditional stone mill. During the grinding process, control the speed of the stone mill to ensure uniform grinding. After grinding, pass the powder through an 80-100 mesh sieve to remove any insufficiently ground particles, obtaining a fine powder for internal use. Store the powder in a sealed bag or container in a cool, dry, and ventilated place to prevent moisture absorption and clumping. The shelf life is 6-8 months.

[0012] Furthermore, in step S1, during the fermentation process, the container is opened for ventilation for 1-2 hours every 20 days to observe whether the raw materials show any abnormalities such as mold or odor. If any abnormalities occur, they should be dealt with in a timely manner to ensure the smooth progress of the fermentation process.

[0013] Furthermore, in step S2, process ③, the fineness of the powder being ground is 80-100 mesh.

[0014] Furthermore, the method of using this traditional Chinese medicine composition for treating vitiligo includes: applying the topical herbal paste 2-3 times daily. Before use, wash the affected skin with warm water and dry it. Take an appropriate amount of the topical herbal paste (adjust the amount according to the size of the affected area, generally 5-10g each time), and use a clean cotton swab or spoon to evenly apply the paste to the white patches, controlling the thickness of the application to 0.5-1mm to ensure that the paste completely covers the affected skin. After application, avoid wearing clothes or rubbing the affected area immediately. Allow the paste to dry naturally (generally 15-20 minutes) before resuming daily activities. During use, pay attention to skin reaction. Slight redness and itching are normal. If severe redness, swelling, stinging, blisters or other allergic reactions occur, stop using immediately, wash the affected area with clean water, and consult a doctor if necessary. The oral Chinese medicine powder is taken 3 times a day, 1 spoonful each time, with each spoonful weighing 5-8g; When taking the medicine, you can mix the powder with warm water and then swallow it, or you can mix it into porridge, soy milk or other foods to improve the taste. It is recommended to take this medicine 30 minutes after a meal to avoid irritating the gastrointestinal tract if taken on an empty stomach. Children, pregnant women, breastfeeding women, and the elderly and those with weak constitutions need to adjust the dosage under the guidance of a doctor. Generally, the dosage for children is 1 / 2 to 2 / 3 of that for adults. Pregnant women and breastfeeding women should use it with caution or avoid it altogether.

[0015] This invention provides a traditional Chinese medicine composition for treating vitiligo and its preparation method. It possesses the following beneficial effects: 1. This invention provides a traditional Chinese medicine composition for treating vitiligo and its preparation method. It adopts a treatment method combining external and internal application. The external application composition contains nux vomica and blister beetle, which can stimulate blood circulation in the affected skin and activate melanocytes. Walnut peel, licorice root, and red garlic can protect the skin barrier and reduce inflammatory response. Green persimmon and green fig can nourish the skin. The internal application composition contains rye, black beans, and black sesame seeds, which can supplement nutrition and enhance immunity. Polygonum multiflorum and psoralea corylifolia can regulate the body's metabolism and promote melanin synthesis. The synergistic effect of internal and external application can effectively improve the symptoms of vitiligo.

[0016] 2. This invention provides a traditional Chinese medicine composition for treating vitiligo and its preparation method. The selected Chinese medicinal materials are all common natural medicinal materials with wide sources and their safety has been verified through long-term practice. Compared with Western medicine and hormone therapy, it has fewer side effects. The external composition is processed by fermentation and decoction, which can reduce the irritation of some medicinal materials. The internal composition is more easily digested and absorbed by the human body after being stir-fried, reducing the irritation to the gastrointestinal tract. Moreover, no chemical preservatives, pigments, fragrances or other additives are added during the preparation process, making it safer and more reliable to use.

[0017] 3. This invention provides a traditional Chinese medicine composition for treating vitiligo and its preparation method. The external application of the traditional Chinese medicine paste is thick and dries easily after application, without affecting daily activities. The internal application of the traditional Chinese medicine powder can be taken directly with warm water or mixed into food. It has an easy-to-accept taste and is especially suitable for children and patients with difficulty swallowing. Both dosage forms have a long shelf life, are easy to store and carry, and meet the needs of patients for long-term treatment.

[0018] 4. This invention provides a traditional Chinese medicine composition for treating vitiligo and its preparation method. The preparation method does not require complex equipment or professional technicians. The fermentation and decoction of the external composition and the stir-frying and grinding of the internal composition can be completed by traditional processes. The operation is simple and suitable for home preparation or batch preparation in small medical institutions, which reduces the treatment cost and facilitates its promotion and application in primary medical units and among ordinary patients. Detailed Implementation

[0019] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0020] The effects of each ingredient in this invention are as follows: Strychnos nux-vomica has the effects of clearing the meridians, relieving pain, dispersing nodules and reducing swelling. Its components, such as strychnine, can stimulate the skin, promote local blood circulation, and help activate melanocytes. Cantharides: It has the effects of breaking up blood stasis, dispersing nodules and eliminating lumps, and can improve the microcirculation of the skin in the affected area, providing a good environment for the growth of melanocytes; Walnut skin: It is neutral in nature and bitter in taste. It has the effects of astringing, consolidating, and relieving itching. It can protect the skin of the affected area and reduce external irritation. Green persimmons: rich in vitamin C, carotene and other nutrients, they have the effects of clearing heat, moistening the lungs and promoting body fluid production, and can nourish the skin and promote skin repair; Green figs: Rich in various enzymes, amino acids and minerals, they have the effects of strengthening the spleen and stomach, detoxifying and reducing swelling, and can enhance the skin's resistance; Baicaoshuang: It is the soot that adheres to the hearth or chimney after burning weeds. It has the effects of stopping bleeding, eliminating stagnation, and detoxifying, and can reduce the inflammatory reaction of the skin in the affected area. Red garlic contains active ingredients such as allicin, which have antibacterial, anti-inflammatory, and antioxidant effects. It can inhibit the growth of harmful microorganisms on the skin surface and protect the skin barrier. Rye: Rich in protein, dietary fiber, B vitamins and minerals, it has the effects of invigorating qi, clearing heat and quenching thirst, and can supplement the body's nutrition and enhance the body's immunity; Black beans: They have the effects of nourishing the kidneys and yin, strengthening the spleen and removing dampness, and dispelling wind and relieving numbness. Traditional Chinese medicine believes that "the health of the kidneys is reflected in the hair and the strength of the bones". Nourishing the kidneys helps improve skin pigmentation metabolism. Black sesame seeds: They have the effects of nourishing the liver and kidneys, replenishing essence and blood, and moisturizing the intestines. They can nourish the body and provide necessary nutrients for melanin synthesis. Polygonum multiflorum: Processed Polygonum multiflorum has the effects of tonifying the liver and kidneys, nourishing essence and blood, blackening hair, and strengthening muscles and bones. It can regulate the body's immune function and promote the production of melanocytes. Psoralea corylifolia: It has the effects of warming the kidneys and invigorating yang, promoting qi circulation and stopping diarrhea. Its components, such as psoralen, can enhance the skin's sensitivity to ultraviolet rays and promote melanin synthesis.

[0021] Example 1: This embodiment provides a traditional Chinese medicine composition for treating vitiligo, including a topical composition and an oral composition; The topical composition consists of the following raw materials in parts by weight: 3 parts nux vomica, 3 parts blister beetle, 500 parts walnut peel, 250 parts green persimmon, 100 parts green fig, 300 parts ash, and 80 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 2000 parts rye, 1000 parts black beans, 1000 parts black sesame seeds, 250 parts Polygonum multiflorum, and 150 parts Psoralea corylifolia.

[0022] The preparation method of this traditional Chinese medicine composition for treating vitiligo includes the following steps: Step S1. Preparation of the topical composition ① Weigh out the following ingredients by weight: nux vomica, blister beetle, walnut shell, green persimmon, green fig, cypermethrin, and red garlic. Remove the seed coat from the nux vomica, remove the legs and wings from the blister beetle, select fresh walnut shells that are free of mold, remove the pits from the green persimmon and green fig, and peel the red garlic. Wash all the pre-treated ingredients three times with purified water to remove the mud and impurities from the surface, and then drain the surface water. ② Place the drained raw materials into a sealed ceramic or glass container. The container should be disinfected with 75% alcohol and dried beforehand. Then place the container in a dark, dry environment with the ambient temperature controlled at 20℃ and the relative humidity controlled at 55% for 100 days of fermentation. ③ After fermentation, transfer all the raw materials and fermentation liquid from the container to an iron pot, add three times the total weight of the raw materials in purified water, stir well, heat over high heat until boiling, stirring constantly to prevent the raw materials from sticking to the pot, then reduce to low heat and simmer for 3 hours, stirring every 20 minutes until the material becomes a thick paste that can drip naturally without spreading when lifted with a spoon. Stop heating, transfer the external Chinese medicine paste to a clean container, cool to room temperature to obtain the external Chinese medicine paste, and then seal and store it. Step S2. Preparation of the oral composition ① Weigh out the rye, black beans, black sesame seeds, Polygonum multiflorum and Psoralea corylifolia by weight. First, remove impurities such as stones, broken pieces and weeds from the raw materials by screening. Then, wash the screened raw materials twice with pure water to remove surface dust and dirt. After washing, place them in a ventilated place to dry the surface moisture to avoid excessive moisture causing them to burn during subsequent stir-frying. ② Place the dried ingredients into a clean iron pot. Preheat the pot over low heat for 2 minutes, then turn to medium heat and stir-fry. Stir-fry the ingredients constantly with a spatula to ensure even heating. The black wheat, black beans, and black sesame seeds should be stir-fried until they turn slightly yellow and feel plump when rubbed by hand, with a slight aroma. The Polygonum multiflorum and Psoralea corylifolia should be stir-fried until their surface color changes from light brown to dark brown, and they become slightly brittle and not easily broken. During the stir-frying process, closely observe the color and state of the ingredients to avoid burning. If any parts are burnt, turn off the heat immediately and remove the burnt parts. ③ Transfer the cooked raw materials to a clean tray and let them cool to room temperature to prevent residual heat from causing them to burn. Once the raw materials have completely cooled, grind them in a traditional stone mill. During the grinding process, control the speed of the stone mill to ensure uniform grinding. After grinding, pass the powder through a 90-mesh sieve to remove any unground particles, obtaining a fine powder for internal use. Store the powder in a sealed bag or container in a cool, dry, and ventilated place.

[0023] How to use: Use the topical Chinese medicine ointment 2-3 times daily. Before use, wash the affected skin with warm water and dry it. Take an appropriate amount of the ointment (adjust the amount according to the size of the affected area, generally 8g each time). Use a clean cotton swab or spoon to apply the ointment evenly to the vitiligo area, with a thickness of 1mm, ensuring that the ointment completely covers the affected skin. After application, avoid wearing clothes or rubbing the affected area immediately. Allow the ointment to dry naturally (usually 18 minutes) before resuming daily activities. Take the Chinese herbal powder three times a day, one spoonful each time, each spoonful weighing 6g. When taking it, you can mix the Chinese herbal powder with warm water and then swallow it, or you can mix it into porridge, soy milk or other foods and take it together.

[0024] Example 2: This embodiment provides a traditional Chinese medicine composition for treating vitiligo, including a topical composition and an oral composition; The topical composition consists of the following raw materials in parts by weight: 2 parts nux vomica, 2 parts blister beetle, 480 parts walnut shell, 240 parts green persimmon, 90 parts green fig, 280 parts ash, and 70 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 1900 parts rye, 900 parts black beans, 900 parts black sesame seeds, 240 parts Polygonum multiflorum, and 140 parts Psoralea corylifolia.

[0025] The preparation method of this traditional Chinese medicine composition for treating vitiligo includes the following steps: Step S1. Preparation of the topical composition ① Weigh out the following ingredients by weight: nux vomica, blister beetle, walnut shell, green persimmon, green fig, cypermethrin, and red garlic. Remove the seed coat from the nux vomica, remove the legs and wings from the blister beetle, select fresh walnut shells that are free of mold, remove the pits from the green persimmon and green fig, and peel the red garlic. Wash all the pre-treated ingredients three times with purified water to remove the mud and impurities from the surface, and then drain the surface water. ② Place the drained raw materials into a sealed ceramic or glass container. The container should be disinfected with 75% alcohol and dried beforehand. Then place the container in a dark, dry environment with the ambient temperature controlled at 20℃ and the relative humidity controlled at 55% for 100 days of fermentation. ③ After fermentation, transfer all the raw materials and fermentation liquid from the container to an iron pot, add three times the total weight of the raw materials in purified water, stir well, heat over high heat until boiling, stirring constantly to prevent the raw materials from sticking to the pot, then reduce to low heat and simmer for 3 hours, stirring every 20 minutes until the material becomes a thick paste that can drip naturally without spreading when lifted with a spoon. Stop heating, transfer the external Chinese medicine paste to a clean container, cool to room temperature to obtain the external Chinese medicine paste, and then seal and store it. Step S2. Preparation of the oral composition ① Weigh out the rye, black beans, black sesame seeds, Polygonum multiflorum and Psoralea corylifolia by weight. First, remove impurities such as stones, broken pieces and weeds from the raw materials by screening. Then, wash the screened raw materials twice with pure water to remove surface dust and dirt. After washing, place them in a ventilated place to dry the surface moisture to avoid excessive moisture causing them to burn during subsequent stir-frying. ② Place the dried ingredients into a clean iron pot. Preheat the pot over low heat for 2 minutes, then turn to medium heat and stir-fry. Stir-fry the ingredients constantly with a spatula to ensure even heating. The black wheat, black beans, and black sesame seeds should be stir-fried until they turn slightly yellow and feel plump when rubbed by hand, with a slight aroma. The Polygonum multiflorum and Psoralea corylifolia should be stir-fried until their surface color changes from light brown to dark brown, and they become slightly brittle and not easily broken. During the stir-frying process, closely observe the color and state of the ingredients to avoid burning. If any parts are burnt, turn off the heat immediately and remove the burnt parts. ③ Transfer the cooked raw materials to a clean tray and let them cool to room temperature to prevent residual heat from causing them to burn. Once the raw materials have completely cooled, grind them in a traditional stone mill. During the grinding process, control the speed of the stone mill to ensure uniform grinding. After grinding, pass the powder through a 90-mesh sieve to remove any unground particles, obtaining a fine powder for internal use. Store the powder in a sealed bag or container in a cool, dry, and ventilated place.

[0026] How to use: Use the topical Chinese medicine ointment 2-3 times daily. Before use, wash the affected skin with warm water and dry it. Take an appropriate amount of the ointment (adjust the amount according to the size of the affected area, generally 8g each time). Use a clean cotton swab or spoon to apply the ointment evenly to the vitiligo area, with a thickness of 1mm, ensuring that the ointment completely covers the affected skin. After application, avoid wearing clothes or rubbing the affected area immediately. Allow the ointment to dry naturally (usually 18 minutes) before resuming daily activities. Take the Chinese herbal powder three times a day, one spoonful each time, each spoonful weighing 6g. When taking it, you can mix the Chinese herbal powder with warm water and then swallow it, or you can mix it into porridge, soy milk or other foods and take it together.

[0027] Example 3: This embodiment provides a traditional Chinese medicine composition for treating vitiligo, including a topical composition and an oral composition; The external application composition consists of the following raw materials in parts by weight: 4 parts nux vomica, 4 parts blister beetle, 520 parts walnut peel, 260 parts green persimmon, 110 parts green fig, 320 parts ash, and 90 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 2100 parts rye, 1100 parts black beans, 1100 parts black sesame seeds, 260 parts Polygonum multiflorum, and 160 parts Psoralea corylifolia.

[0028] The preparation method of this traditional Chinese medicine composition for treating vitiligo includes the following steps: Step S1. Preparation of the topical composition ① Weigh out the following ingredients by weight: nux vomica, blister beetle, walnut shell, green persimmon, green fig, cypermethrin, and red garlic. Remove the seed coat from the nux vomica, remove the legs and wings from the blister beetle, select fresh walnut shells that are free of mold, remove the pits from the green persimmon and green fig, and peel the red garlic. Wash all the pre-treated ingredients three times with purified water to remove the mud and impurities from the surface, and then drain the surface water. ② Place the drained raw materials into a sealed ceramic or glass container. The container should be disinfected with 75% alcohol and dried beforehand. Then place the container in a dark, dry environment with the ambient temperature controlled at 20℃ and the relative humidity controlled at 55% for 100 days of fermentation. ③ After fermentation, transfer all the raw materials and fermentation liquid from the container to an iron pot, add three times the total weight of the raw materials in purified water, stir well, heat over high heat until boiling, stirring constantly to prevent the raw materials from sticking to the pot, then reduce to low heat and simmer for 3 hours, stirring every 20 minutes until the material becomes a thick paste that can drip naturally without spreading when lifted with a spoon. Stop heating, transfer the external Chinese medicine paste to a clean container, cool to room temperature to obtain the external Chinese medicine paste, and then seal and store it. Step S2. Preparation of the oral composition ① Weigh out the rye, black beans, black sesame seeds, Polygonum multiflorum and Psoralea corylifolia by weight. First, remove impurities such as stones, broken pieces and weeds from the raw materials by screening. Then, wash the screened raw materials twice with pure water to remove surface dust and dirt. After washing, place them in a ventilated place to dry the surface moisture to avoid excessive moisture causing them to burn during subsequent stir-frying. ② Place the dried ingredients into a clean iron pot. Preheat the pot over low heat for 2 minutes, then turn to medium heat and stir-fry. Stir-fry the ingredients constantly with a spatula to ensure even heating. The black wheat, black beans, and black sesame seeds should be stir-fried until they turn slightly yellow and feel plump when rubbed by hand, with a slight aroma. The Polygonum multiflorum and Psoralea corylifolia should be stir-fried until their surface color changes from light brown to dark brown, and they become slightly brittle and not easily broken. During the stir-frying process, closely observe the color and state of the ingredients to avoid burning. If any parts are burnt, turn off the heat immediately and remove the burnt parts. ③ Transfer the cooked raw materials to a clean tray and let them cool to room temperature to prevent residual heat from causing them to burn. Once the raw materials have completely cooled, grind them in a traditional stone mill. During the grinding process, control the speed of the stone mill to ensure uniform grinding. After grinding, pass the powder through a 90-mesh sieve to remove any unground particles, obtaining a fine powder for internal use. Store the powder in a sealed bag or container in a cool, dry, and ventilated place.

[0029] How to use: Use the topical Chinese medicine ointment 2-3 times daily. Before use, wash the affected skin with warm water and dry it. Take an appropriate amount of the ointment (adjust the amount according to the size of the affected area, generally 8g each time). Use a clean cotton swab or spoon to apply the ointment evenly to the vitiligo area, with a thickness of 1mm, ensuring that the ointment completely covers the affected skin. After application, avoid wearing clothes or rubbing the affected area immediately. Allow the ointment to dry naturally (usually 18 minutes) before resuming daily activities. Take the Chinese herbal powder three times a day, one spoonful each time, each spoonful weighing 6g. When taking it, you can mix the Chinese herbal powder with warm water and then swallow it, or you can mix it into porridge, soy milk or other foods and take it together.

[0030] Example 4: This embodiment provides a traditional Chinese medicine composition for treating vitiligo, including a topical composition and an oral composition; The topical composition consists of the following raw materials in parts by weight: 3 parts nux vomica, 3 parts blister beetle, 500 parts walnut peel, 250 parts green persimmon, 100 parts green fig, 300 parts ash, and 80 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 2000 parts rye, 1000 parts black beans, 1000 parts black sesame seeds, 250 parts Polygonum multiflorum, and 150 parts Psoralea corylifolia.

[0031] The preparation method of this traditional Chinese medicine composition for treating vitiligo includes the following steps: Step S1. Preparation of the topical composition ① The raw material pretreatment is the same as in Example 1, and the raw materials are washed and drained; ② Place in a glass container and ferment in a dark environment at 18℃ for 100 days, ventilating for 1 hour every 20 days; ③ After fermentation, add twice the amount of purified water, bring to a boil over high heat, then simmer over low heat for 2 hours until it becomes a paste. Cool and seal.

[0032] Step S2. Preparation of the oral composition ① The raw materials are screened and cleaned in the same way as in Example 1, and then stir-fried after being dried; ② Stir-fry over medium heat until the raw materials meet the requirements, then grind them with a stone mill after cooling and pass them through an 80-mesh sieve.

[0033] How to use: For external use, take 5g three times a day; for internal use, take 5g three times a day, mixed into porridge.

[0034] Clinical trials have shown that the traditional Chinese medicine compositions in Examples 1, 2, 3, and 4 can effectively improve the symptoms of vitiligo in patients with vitiligo, and no obvious adverse reactions have been observed.

[0035] The following points should be noted in this article: 1. The embodiments disclosed herein only relate to the structures involved in the embodiments disclosed herein; other structures may refer to general designs.

[0036] 2. Where there is no conflict, the embodiments of this disclosure and the features in the embodiments can be combined with each other to obtain new embodiments.

[0037] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating vitiligo, characterized in that, Including topical and oral compositions; The external application composition consists of the following raw materials in parts by weight: 2-4 parts of nux vomica, 2-4 parts of blister beetle, 480-520 parts of walnut shell, 240-260 parts of green persimmon, 90-110 parts of green fig, 280-320 parts of herbal ash, and 70-90 parts of red garlic. The oral composition consists of the following raw materials in parts by weight: 1900-2100 parts of rye, 900-1100 parts of black beans, 900-1100 parts of black sesame seeds, 240-260 parts of Polygonum multiflorum, and 140-160 parts of Psoralea corylifolia.

2. The traditional Chinese medicine composition for treating vitiligo according to claim 1, characterized in that, Including topical and oral compositions; The topical composition consists of the following raw materials in parts by weight: 3 parts nux vomica, 3 parts blister beetle, 500 parts walnut peel, 250 parts green persimmon, 100 parts green fig, 300 parts cypermethrin, and 80 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 2000 parts rye, 1000 parts black beans, 1000 parts black sesame seeds, 250 parts Polygonum multiflorum, and 150 parts Psoralea corylifolia.

3. The traditional Chinese medicine composition for treating vitiligo according to claim 1, characterized in that, Including topical and oral compositions; The topical composition consists of the following raw materials in parts by weight: 2 parts nux vomica, 2 parts blister beetle, 480 parts walnut peel, 240 parts green persimmon, 90 parts green fig, 280 parts cypermethrin, and 70 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 1900 parts rye, 900 parts black beans, 900 parts black sesame seeds, 240 parts Polygonum multiflorum, and 140 parts Psoralea corylifolia.

4. The traditional Chinese medicine composition for treating vitiligo according to claim 1, characterized in that, Including topical and oral compositions; The topical composition consists of the following raw materials in parts by weight: 4 parts nux vomica, 4 parts blister beetle, 520 parts walnut peel, 260 parts green persimmon, 110 parts green fig, 320 parts cypermethrin, and 90 parts red garlic. The oral composition consists of the following ingredients in parts by weight: 2100 parts rye, 1100 parts black beans, 1100 parts black sesame seeds, 260 parts Polygonum multiflorum, and 160 parts Psoralea corylifolia.

5. A method for preparing a traditional Chinese medicine composition for treating vitiligo as described in claim 1, characterized in that, Includes the following steps: Step S1. Preparation of the topical composition ① Weigh out the following ingredients by weight: nux vomica, blister beetle, walnut shell, green persimmon, green fig, cyperus tinctoria, and red garlic. After cleaning all the ingredients, remove the pits from the green persimmon and green fig, and peel the red garlic. ② Put the processed raw materials into a sealed container, and then place the sealed container containing the raw materials in a dark, dry environment with a temperature maintained at 15-25℃ for 100 days of fermentation. ③ After fermentation, transfer all the raw materials in the container to an iron pot, add 2-3 times the total weight of the raw materials in purified water, heat it over high heat until it boils, then turn to low heat and continue to simmer for 2-3 hours, stirring constantly until the material becomes a paste. Stop heating and let it cool to obtain the external Chinese medicine paste. Step S2. Preparation of the oral composition ① Weigh out the rye, black beans, black sesame seeds, Polygonum multiflorum and Psoralea corylifolia by weight. After screening all the raw materials to remove impurities, wash them clean and dry the surface moisture. ② Place the dried ingredients into an iron pot and stir-fry over medium heat. Stir-fry the rye, black beans, and black sesame seeds until they turn slightly yellow and have a fragrant aroma. Stir-fry the Polygonum multiflorum and Psoralea corylifolia until they darken in color and become slightly brittle. Stir the ingredients constantly to prevent them from burning. ③ After the raw materials have been stir-fried, cool them to room temperature, then put them into a stone mill and grind them into powder. After sifting, you will get the Chinese medicine powder for internal use.

6. The method for preparing the traditional Chinese medicine composition for treating vitiligo according to claim 5, characterized in that, In step S1, during process ②, the container is opened for ventilation for 1-2 hours every 20 days during fermentation to ensure that the fermentation process proceeds normally.

7. The method for preparing the traditional Chinese medicine composition for treating vitiligo according to claim 5, characterized in that, In step S2, process ③, the fineness of the powder being ground is 80-100 mesh.

8. A method of using a traditional Chinese medicine composition for treating vitiligo as described in claims 1-7, characterized in that, The topical Chinese medicine ointment is used 2-3 times a day. Each time, take an appropriate amount and apply it evenly to the vitiligo area. The thickness of the application should be 0.5-1mm. After application, keep the skin of the affected area clean and avoid friction. The oral Chinese medicine powder is taken three times a day, one spoonful each time, with warm water, or mixed into porridge or soy milk.