Laryngeal medicine atomizer and intelligent flow rate regulation and control system thereof

Abstract

The invention relates to the technical field of atomizer regulation and control, in particular to a laryngeal medicine atomizer and an intelligent flow rate regulation and control system thereof. The system is used for determining a basic breathing state of a patient according to historical treatment information of the patient, and determining an initial atomization flow rate based on the basic breathing state; collecting real-time monitoring data, and determining an initial state normal degree index and a throat real-time stress degree index according to the real-time monitoring data; the initial atomization flow velocity is corrected according to the initial state normal degree index and the throat real-time stress degree index, and the corrected atomization flow velocity is obtained; and a control instruction is determined based on the corrected atomization flow speed, so that the atomizer outputs atomized medicine based on the control instruction. According to the invention, the accuracy of atomization flow rate control can be improved.

Description

Technical Field

[0001] This invention relates to the technical field of nebulizer control, specifically to a throat medication nebulizer and its intelligent flow rate control system. Background Technology

[0002] A laryngeal nebulizer is a medical device used to convert liquid medication into fine aerosols for targeted local delivery, making it particularly suitable for treating inflammation in the throat area and postoperative recovery. Traditional laryngeal nebulizers primarily utilize gas jets or ultrasound principles to atomize medication into tiny particles for patients to nebulize and treat throat conditions. Currently, most traditional nebulizers employ a fixed flow rate design, which makes it difficult to adapt to individual breathing differences, easily leading to medication waste or inaccurate deposition.

[0003] Currently, the flow rate of existing nebulizers is usually fixed or roughly adjustable manually. When a patient experiences throat discomfort (such as pain or edema), causing abnormal nebulization patterns, the system cannot dynamically adjust according to the patient's real-time throat condition, respiratory status, and drug deposition requirements. This may result in the drug not being effectively deposited in the target area of ​​the throat, thus affecting the treatment effect.

[0004] In other words, existing technologies have low accuracy in controlling atomization flow rate. Summary of the Invention

[0005] The purpose of this invention is to provide a throat nebulizer and its intelligent flow rate control system to solve the technical problem of low accuracy in nebulization flow rate control in the prior art.

[0006] In a first aspect, one embodiment of the present invention provides a throat nebulizer and its intelligent flow rate control system, the system comprising: The initial state determination module is used to determine the patient's baseline respiratory state based on the patient's historical medical information, and to determine the initial nebulization flow rate based on the baseline respiratory state. The data processing module is used to collect real-time monitoring data and determine the initial state normality index and the laryngeal real-time stress index based on the real-time monitoring data. The real-time monitoring data includes nebulization time series data and laryngeal time series data. The initial state normality index is used to characterize the adaptability of the initial nebulization flow rate setting. The laryngeal real-time stress index is used to characterize the laryngeal tolerance to the real-time nebulization flow rate. The correction module is used to correct the initial atomization flow rate based on the initial state normality index and the real-time throat stress index to obtain the corrected atomization flow rate. The control module is used to determine control commands based on the corrected atomization flow rate, so that the nebulizer can output atomized drugs according to the control commands.

[0007] In some embodiments, determining a patient's baseline respiratory status based on their historical medical records includes: Retrieve the number of disease keywords and the number of visits related to medical treatment from historical medical records; Based on preset coefficients, the number of symptom keywords and the number of times a patient visits for medical treatment are weighted and summed to determine the patient's baseline respiratory status.

[0008] In some embodiments, determining the initial nebulization flow rate based on baseline respiratory status includes: Determine the absolute value of the difference between the patient's baseline respiratory status and the baseline respiratory status of historical patients; Based on the absolute value of the difference in baseline respiratory status and a preset threshold, at least one reference historical patient is identified; The initial nebulization flow rate of a patient is determined based on the mean of the initial nebulization flow rates of at least one reference historical patient.

[0009] In some embodiments, the atomization time-series data includes atomization pressure time-series data and atomization flow rate time-series data. Based on real-time monitoring data, an initial state normality index is determined, including: The initial stable value of atomization pressure is determined based on the variance of the atomization pressure time series data within a preset time period; The average nebulization flow rate of the patient is determined based on the mean of the nebulization flow rate time series data within a preset time period; Based on the initial stable value of atomization pressure, average atomization flow rate, and initial atomization velocity, determine the indicators of the normality of the initial state.

[0010] In some embodiments, the laryngeal time series includes a laryngeal vibration time series and a laryngeal pressure time series. Based on real-time monitoring data, an index of real-time laryngeal stress level is determined, including: Based on the laryngeal time sequence within a preset time period and a preset trigger threshold, determine the cough events and the number of cough events; The target mean is determined by the sum of the first mean of the absolute values ​​of the differences between the laryngeal vibration signal corresponding to the cough event and the preset vibration threshold, and the second mean of the absolute values ​​of the differences between the laryngeal pressure signal corresponding to the cough event and the preset pressure threshold. The real-time stress level of the larynx was determined based on the number of cough events and the target mean.

[0011] In some embodiments, the initial nebulization flow rate is corrected based on an initial state normality index and a real-time throat stress index to obtain a corrected nebulization flow rate, including: Based on the initial state normality index, the real-time throat stress index, the flow rate adjustment coefficient, and the initial atomization flow rate, the adjusted atomization flow rate is determined; the flow rate adjustment coefficient is used to characterize the adjustable range benchmark of the initial atomization flow rate. The corrected atomization flow rate is determined based on the preset lower limit atomization flow rate threshold and the adjusted atomization flow rate.

[0012] In some embodiments, after determining the control command based on the modified atomization flow rate, the method further includes: Within a preset sliding time window, the updated initial state normality index is determined based on the corrected atomization flow rate and real-time monitoring data. Based on the updated initial state normality index and the preset normality index threshold, the atomization flow rate control strategy is determined, and the control command is updated based on the atomization flow rate control strategy.

[0013] In some embodiments, atomization flow rate control strategy is determined based on an updated initial state normality index and a preset normality index threshold, including: If the updated initial state normality index is greater than or equal to the preset normality index threshold, the atomization flow rate control strategy is determined to maintain the corrected atomization flow rate. If the updated initial state normality index is less than the preset normality index threshold, the atomization flow rate control strategy is determined to be the updated and corrected atomization flow rate, and the corrected atomization flow rate is updated based on the updated initial state normality index and the real-time throat stress index.

[0014] In some embodiments, after collecting real-time monitoring data, the method further includes: An abnormal event is identified when the amplitude increase of the laryngeal signal in the laryngeal time sequence is greater than or equal to a preset increase; abnormal events include coughing events. In the event of an abnormal event, an emergency control command is determined so that the nebulizer can output nebulized medication based on the emergency control command; the emergency control command is used to adjust the current nebulization flow rate to a preset safe nebulization flow rate value.

[0015] Secondly, another embodiment of the present invention provides a throat nebulizer and a method for intelligent flow rate control thereon, the method comprising: Based on the patient's historical medical history, determine the patient's baseline respiratory status, and determine the initial nebulization flow rate based on the baseline respiratory status; Real-time monitoring data is collected, and based on the real-time monitoring data, the initial state normality index and the laryngeal real-time stress index are determined. The real-time monitoring data includes nebulization time series data and laryngeal time series data. The initial state normality index is used to characterize the adaptability of the initial nebulization flow rate setting. The laryngeal real-time stress index is used to characterize the laryngeal tolerance to the real-time nebulization flow rate. The initial nebulization flow rate was corrected based on the initial state normality index and the real-time throat stress index to obtain the corrected nebulization flow rate. The control command is determined based on the modified atomization flow rate, so that the nebulizer outputs atomized medication according to the control command.

[0016] Thirdly, in another embodiment of the present invention, an electronic device is provided, including a processor, a memory, and a computer program stored in the memory and executable on the processor, wherein the computer program, when executed by the processor, implements the steps of the method described in the second aspect above.

[0017] Fourthly, in another embodiment of the present invention, a computer-readable storage medium is provided, on which a computer program is stored, which, when executed by a processor, implements the steps of the method described in the second aspect above.

[0018] The present invention has the following beneficial effects: This invention determines the initial nebulization flow rate suitable for an individual's underlying condition by combining the patient's historical medical information. Then, based on real-time monitoring data such as nebulization time-series data and laryngeal time-series data, it constructs an initial state normality index and a real-time laryngeal stress index, and dynamically adjusts the nebulization flow rate accordingly, ultimately outputting control commands. This avoids the problem of traditional fixed or manual flow rate adjustments being difficult to adapt to individual differences, and can respond in real time to changes in the patient's respiratory state and laryngeal response. It effectively reduces laryngeal irritation caused by improper flow rate, improves treatment comfort, and ensures effective drug deposition in the laryngeal target area to optimize treatment effects, thus improving the accuracy of nebulization flow rate control. Attached Figure Description

[0019] To more clearly illustrate the technical solutions and advantages in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the structure of a throat drug nebulizer and its intelligent flow rate control system provided in an embodiment of the present invention; Figure 2 This is a schematic flowchart of a throat drug nebulizer and its intelligent flow rate control method provided in an embodiment of the present invention; Figure 3 This is a schematic diagram of an electronic device provided in an embodiment of the present invention. Detailed Implementation

[0021] To further illustrate the technical means and effects adopted by the present invention to achieve its intended purpose, the following, in conjunction with the accompanying drawings and preferred embodiments, details the specific implementation, structure, features, and effects of the throat drug nebulizer and its intelligent flow rate control system proposed according to the present invention. In the following description, different "one embodiment" or "another embodiment" do not necessarily refer to the same embodiment. Furthermore, specific features, structures, or characteristics in one or more embodiments can be combined in any suitable form.

[0022] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0023] The specific solution of the throat drug nebulizer and its intelligent flow rate control system provided by the present invention will be described in detail below with reference to the accompanying drawings.

[0024] It should be noted that the throat nebulizer and its intelligent flow rate control system of the present invention are applicable to intelligent terminals (including hospital bedside medical terminals, patient-side intelligent diagnosis and treatment APPs, cross-institutional data sharing servers, etc.) in the context of collaborative diagnosis and treatment in medical consortia.

[0025] In one embodiment, the present invention provides a throat nebulizer and its intelligent flow rate control system 100, such as... Figure 1 As shown, the system 100 includes: The initial state determination module 101 is used to determine the patient's basic respiratory state based on the patient's historical medical information, and to determine the initial nebulization flow rate based on the basic respiratory state.

[0026] Historical medical records refer to static data related to the larynx and respiratory system in the patient's electronic medical records, including diagnostic records, surgical records, and previous treatment records of the larynx and respiratory system. These records are used to assess the patient's basic health status. Historical medical records related to the larynx and respiratory system can be obtained not only through real-time network access, but also through medical history tags entered by the user on the App, or through summary data generated by scanning medical records using OCR.

[0027] Baseline respiratory status refers to an indicator obtained by quantifying the severity of a patient's laryngeal and respiratory-related conditions, reflecting the strength and stability of the patient's basic respiratory capacity. Jieba word segmentation can be used to extract laryngeal / respiratory-related keywords (such as vocal cord edema) from diagnostic records, count the number of keywords, and combine this with surgical records and previous treatment counts. A higher baseline respiratory status indicates weaker / unstable baseline respiratory capacity.

[0028] The initial nebulization flow rate can be a personalized baseline for initial nebulization drug delivery, determined based on matching data from similar historical patients, avoiding the adaptability issues of traditional fixed flow rates. For example, reference historical patients in the database whose absolute difference between their baseline respiratory status and the current patient's is less than a preset threshold can be selected, and the average of their initial flow rates can be used as the initial nebulization flow rate for the current patient.

[0029] For example, in an embodiment of the present invention, based on the patient's historical medical information, the basic respiratory state is obtained by quantifying the severity of the disease, and then the initial nebulization flow rate is determined by matching the treatment data of similar historical patients, so as to provide a data basis for subsequent real-time dynamic adjustment of the flow rate.

[0030] Furthermore, based on the patient's historical medical history, the patient's baseline respiratory status is determined, including: Retrieve the number of disease-related keywords and the number of visits from historical medical records.

[0031] The number of disease keywords refers to the total number of keywords directly related to laryngeal function and respiratory intensity (such as vocal cord edema and bronchitis) selected based on a preset knowledge base after the disease description section in the historical medical information is segmented by the Jieba word segmentation tool. The more keywords there are, the higher the severity of the patient's condition.

[0032] The number of visits refers to the cumulative number of surgical records and previous treatments obtained by integrating historical medical information. The higher the number, the more severe the patient's laryngeal condition and the weaker the patient's basic respiratory condition may be.

[0033] For example, the number of disease keywords related to the throat / respiratory system and the cumulative number of surgeries and previous treatments can be extracted from the patient's historical medical records (electronic medical records) to provide data input for subsequent calculation of the baseline respiratory status through weighted summation and normalization.

[0034] Based on preset coefficients, the number of symptom keywords and the number of times a patient visits for medical treatment are weighted and summed to determine the patient's baseline respiratory status.

[0035] Among them, the preset coefficient refers to the pre-set weighting parameter used to balance the importance of the number of symptom keywords and the number of visits when assessing the patient's basic respiratory status, so as to ensure that the two indicators are reasonably allocated in the calculation.

[0036] The calculation method involves assigning corresponding weights to the number of disease-related keywords and the number of visits to a doctor using preset coefficients, and then summing the results. This method integrates information from the two indicators to quantify the patient's basic condition.

[0037] The baseline respiratory status can be quantified by weighting the number of symptom keywords and the number of visits, and then performing min-max normalization. The larger the value, the weaker or more unstable the patient's baseline respiratory status, which is used to determine the initial flow rate of the nebulizer.

[0038] For example, the basic respiratory state can be represented as: ; in, This indicates the patient's baseline respiratory status. This represents the normalization function (using the min-max normalization method). This indicates the number of keywords related to the patient's symptoms. This indicates the number of times a patient has visited a hospital (surgical records and previous treatments). and This indicates the preset coefficient.

[0039] It should be noted that in the process of calculating the baseline respiratory status, the 3σ principle (σ refers to the standard deviation of the baseline respiratory status of all patients) can be used to remove outlier data of extremely critically ill patients in the historical database.

[0040] For example, the number of disease keywords is first extracted from medical records through word segmentation and knowledge base identification, and the number of surgeries and previous treatments related to the visit is counted. Then, these two indicators are weighted and summed according to preset weight coefficients. Finally, after normalization processing, the quantitative value of the basic respiratory state reflecting the patient's basic laryngeal state and respiratory stability is obtained, which provides data for matching the initial flow rate of the nebulizer.

[0041] Furthermore, the initial nebulization flow rate is determined based on the baseline respiratory state, including: The absolute value of the difference between the patient's baseline respiratory status and that of historical patients was determined.

[0042] Among them, the baseline respiratory status of historical patients refers to the baseline respiratory status indicators of other patients whose disease type is related to the current patient and are stored in the database. These indicators are all derived using the same calculation logic as the current patient (word segmentation to extract keywords, weighted summation, and normalization), and are used as a reference benchmark for the current patient.

[0043] The absolute value of the baseline respiratory state difference refers to the difference between the baseline respiratory state of the current patient and that of a single historical patient, and is obtained by taking the absolute value. It is used to quantify the similarity between the baseline respiratory states of the current patient and historical patients; the smaller the absolute value of the difference, the more similar the two states are.

[0044] For example, by calculating the absolute value of the difference between the baseline respiratory status of the current patient and the historical patients in the database, the similarity between their baseline respiratory status is quantified, providing a basis for subsequent screening of reference historical patients and determining the initial nebulization flow rate.

[0045] Based on the absolute value of the difference in baseline respiratory status and a preset threshold, at least one reference historical patient is identified.

[0046] The preset threshold refers to the critical value used to determine whether the baseline respiratory status of the current patient is similar to that of historical patients. It is used to filter historical patient data that has reference value. For example, the preset threshold can be 0.2, but it is not limited in the embodiments of the present invention.

[0047] The reference historical patients refer to historical patients in the database whose absolute value of the difference between their baseline respiratory status and that of the current patient is less than a preset threshold. Their nebulizer initial flow rate data can be used as a reference for setting the initial flow rate of the current patient.

[0048] For example, a baseline respiratory status index reflecting the patient's basic respiratory condition is first calculated using the patient's medical record data. Then, this index is compared with the baseline respiratory status of historical patients in the database, and the absolute value of the difference between the two is calculated. Finally, historical patients whose absolute value of the difference is less than a preset threshold are selected as reference objects for setting the initial flow rate of the current patient.

[0049] The initial nebulization flow rate of a patient is determined based on the mean of the initial nebulization flow rates of at least one reference historical patient.

[0050] The initial nebulization flow rate refers to the initial output flow rate of the nebulizer set for the current patient. It is a baseline value that is subsequently corrected based on the real-time status. It is used to provide the patient with an initial aerosol output rate that is adapted to the patient's basic respiratory state, ensuring the initial effectiveness of drug deposition.

[0051] It should be noted that by calculating the average of the initial nebulization flow rates corresponding to all eligible historical patients, individual differences are balanced, providing a more universal and safer initial flow rate reference for current patients.

[0052] For example, the patient's baseline respiratory status is first calculated by analyzing the patient's medical record data. Then, reference historical patients with similar baseline respiratory status are matched from the database. Finally, the average initial nebulization flow rate of these reference historical patients is used as the initial nebulization flow rate of the current patient to ensure that the initial flow rate is adapted to the patient's baseline laryngeal and respiratory status.

[0053] The data processing module 102 is used to collect real-time monitoring data and determine the initial state normality index and the laryngeal real-time stress index based on the real-time monitoring data. The real-time monitoring data includes nebulization time series data and laryngeal time series data. The initial state normality index is used to characterize the adaptability of the initial nebulization flow rate setting. The laryngeal real-time stress index is used to characterize the tolerance of the laryngeal to the real-time nebulization flow rate.

[0054] Real-time monitoring data refers to various dynamic data continuously collected during the process of patients using a throat nebulizer, including nebulization time sequence data and throat time sequence data.

[0055] Nebulization time-series data refers to patient nebulization-related data that changes over time and is collected through airflow sensors, including nebulization pressure time-series data and nebulization flow rate time-series data.

[0056] The laryngeal time series refers to the laryngeal activity data that changes over time, obtained by collecting data from laryngeal contact sensors (such as flexible piezoelectric sensors and accelerometers) and converting it from analog to digital. It includes laryngeal vibration time series (reflecting the dynamic changes of laryngeal vibration) and laryngeal pressure time series (reflecting the dynamic changes of laryngeal pressure).

[0057] The initial state normality index is a quantitative indicator calculated based on nebulization time-series data during the initial stage of nebulization (e.g., the first 20 seconds). It is used to characterize the suitability of the preset initial nebulization flow rate with the patient's actual nebulization state. The larger the value of this index, the better the initial flow rate setting matches the patient's current state; the smaller the value, the less suitable the initial flow rate is, and it needs to be corrected.

[0058] The initial nebulization flow rate refers to the initial nebulization output rate determined based on the patient's baseline respiratory status (calculated from medical record data) and by referring to the average nebulization flow rate of patients with similar historical statuses in the database. It serves as the baseline value for subsequent flow rate adjustments.

[0059] The laryngeal real-time stress index is a quantitative indicator calculated based on the laryngeal time sequence during the initial stage of nebulization. It is used to characterize the patient's tolerance to the current real-time nebulization flow rate. The higher the value of this index, the stronger the laryngeal stress response to the current flow rate (such as frequent coughing or abnormal signal amplitude), and the lower the tolerance; conversely, the lower the value, the higher the tolerance.

[0060] For example, the atomization time series data (atomization pressure and flow time series data) and throat time series data (throat vibration and pressure time series) during the atomization process are first collected through a multi-parameter monitoring module. Then, based on these real-time monitoring data, the initial state normality index for judging the adaptability of the initial atomization flow rate and the throat real-time stress index for judging the throat's tolerance to the current flow rate are calculated respectively, providing a quantitative basis for whether the initial flow rate and the corrected flow rate need to be adjusted in the future.

[0061] Furthermore, the atomization time-series data includes atomization pressure time-series data and atomization flow rate time-series data. Based on real-time monitoring data, indicators of the initial state of normality are determined, including: The initial stable value of atomization pressure is determined based on the variance of the atomization pressure time series data within a preset time period.

[0062] The preset time period refers to the fixed monitoring duration during the initial stage of nebulization (e.g., the preset time period can be 20 seconds), which is used to collect patient status data in the early stage of nebulization, providing a basis for subsequent assessment of the initial flow rate adaptability.

[0063] Nebulization pressure time series data refers to the set of patient nebulization end pressure data that is continuously collected over time by airflow sensors during the nebulization process, reflecting the pressure fluctuations during patient nebulization.

[0064] For example, the fluctuation of atomization pressure can be obtained by quantifying the dispersion of atomization pressure time series data within a preset time period.

[0065] The initial nebulization pressure stability value refers to an index obtained by calculating the variance of nebulization pressure time series data within a preset time period. It directly characterizes the stability of nebulization pressure in the initial stage of nebulization for patients. The larger the value, the more stable the pressure.

[0066] For example, using a preset time period (e.g., 20 seconds) in the initial stage of nebulization as the statistical range, the variance of the nebulization pressure time series data within this period is calculated to quantify the pressure stability of the patient during the initial nebulization, providing data support for subsequent comprehensive calculation of the normality index of the initial nebulization state and judgment of the initial flow rate suitability.

[0067] The average nebulization flow rate for patients is determined based on the mean of the nebulization flow rate time series data within a preset time period.

[0068] Among them, the nebulization flow time series data refers to the patient's nebulization end flow data sequence, which is collected in real time by the airflow sensor of the nebulizer and arranged in chronological order, reflecting the changes in nebulization flow at different times during the nebulization process.

[0069] The average nebulization flow rate is obtained by arithmetically averaging all nebulization flow rate data collected within a preset time period. This eliminates random fluctuations in flow rate data at individual moments and objectively reflects the overall level of nebulization flow rate for patients within that time period.

[0070] It should be noted that the matching degree between the average nebulization flow rate and the nebulizer's set flow rate will affect the drug deposition effect.

[0071] For example, a fixed time period is first set, and the nebulization flow rate time sequence data of the patient during nebulization is collected by the airflow sensor within that period. Then, the arithmetic mean of these flow rate data arranged by time is calculated, and finally the average nebulization flow rate that can reflect the overall nebulization flow rate level of the patient during that time period is obtained.

[0072] Based on the initial stable value of atomization pressure, average atomization flow rate, and initial atomization velocity, determine the indicators of the normality of the initial state.

[0073] The initial nebulization pressure stability value refers to the variance of the nebulization pressure time series data within the initial time T of nebulization (e.g., the initial 20 seconds). The larger this value, the higher the stability of the nebulization pressure in the initial stage of nebulization.

[0074] Average nebulization flow rate refers to the average nebulization flow rate of a patient at the initial time T of nebulization. It reflects the average inhalation volume of the patient during the initial nebulization phase. Combined with the initial nebulization flow rate, the effectiveness of nebulization flow rate can be judged.

[0075] The initial nebulization flow rate refers to the baseline flow rate obtained by matching the absolute value of the difference in baseline respiratory status of the current patient with reference historical patients in the database whose baseline respiratory status difference is less than a preset threshold, and taking the average of the initial nebulization flow rates of these reference patients.

[0076] The initial state normality index is a quantitative indicator calculated from the initial stable nebulization pressure, average nebulization flow rate, and initial nebulization velocity. It is used to determine the effectiveness of the patient's initial nebulization state. The higher the value, the more normal the patient's initial nebulization state; if it is lower than the preset normality index threshold, it indicates that the initial nebulization flow rate may be inaccurate and needs further correction.

[0077] For example, based on the monitoring data at the initial time T of the patient's nebulization, the initial stable value of the nebulization pressure and the average nebulization flow rate are first extracted, and then combined with the preset initial nebulization flow rate, an index of the normality of the initial state can be obtained. Finally, this index is used to determine whether the initial nebulization flow rate needs to be corrected.

[0078] For example, the initial state normality index can be expressed as: ; in, This indicates the degree of normality of the patient's initial condition. This indicates the patient's initial stable nebulization pressure value. This indicates the patient's average nebulization flow rate. This indicates the initial nebulization flow rate for the current patient. This indicates the effectiveness of the current inhalation flow rate for the patient. This indicates the effectiveness of inhalation flow rate for historical patients under the condition that the initial nebulization flow rate of the nebulizer is the same. It is a very small positive value (e.g., 0.001). This is a smoothing coefficient (e.g., 1.0). Adding 1 to the denominator is to avoid a denominator of 0 while also having a normalization effect. This represents the normalization function (using the min-max normalization method). Therefore... A higher value indicates greater stability of the patient's nebulization pressure. The smaller the value, the greater the effectiveness of the nebulization flow for the current patient. Therefore... The higher the value, the more normal the patient's initial nebulization state is.

[0079] It should be noted that in actual calculations, to prevent the denominator from being zero, a very small positive number is added to the denominator term. (e.g., 0.001).

[0080] Furthermore, the laryngeal time series includes laryngeal vibration time series and laryngeal pressure time series. Based on real-time monitoring data, indicators of real-time laryngeal stress level are determined, including: Based on the throat timing sequence within a preset time period and the preset trigger threshold, the cough events and the number of cough events are determined.

[0081] Among them, the preset trigger threshold refers to the judgment threshold set based on the statistical mean of a large number of patients' historical data. The preset trigger threshold includes the preset vibration threshold and the preset pressure threshold, which correspond to the abnormal judgment criteria of the laryngeal vibration time sequence and the laryngeal pressure time sequence, respectively, and are reference values ​​for judging the triggering of cough events.

[0082] For example, a cough event refers to a patient's coughing behavior as determined by preset rules. Specifically, within a preset time period, if the signal amplitude at a single statistical moment in the laryngeal vibration time sequence is greater than a preset vibration threshold and the signal duration is less than a preset duration threshold (e.g., 0.5 seconds), it is determined to be a cough event; or if the signal amplitude at a single statistical moment in the laryngeal pressure time sequence is greater than a preset pressure threshold and the signal duration is less than a preset duration threshold (e.g., 0.5 seconds), it is determined to be a cough event.

[0083] The number of cough events refers to the total number of cough events accumulated within a preset time period according to the cough event judgment rules. It is a parameter for calculating the real-time stress level of the patient's larynx.

[0084] For example, using a preset time period as the monitoring window, the laryngeal time sequence (including laryngeal vibration and pressure time sequence data) is compared with the corresponding preset trigger thresholds (preset vibration threshold and preset pressure threshold). If either the vibration signal amplitude exceeds the vibration threshold or the pressure signal amplitude exceeds the pressure threshold, it is determined as a cough event. Finally, the total number of cough events within the time period is counted.

[0085] The target mean is determined by summing the first mean of the absolute values ​​of the differences between the laryngeal vibration signal corresponding to the cough event and the preset vibration threshold, and the second mean of the absolute values ​​of the differences between the laryngeal pressure signal corresponding to the cough event and the preset pressure threshold.

[0086] Among them, laryngeal vibration signal refers to signal data related to the patient's laryngeal vibration, which is collected by laryngeal contact sensors (such as flexible piezoelectric sensors and accelerometers) and obtained after analog-to-digital conversion. It is the basis for judging cough events.

[0087] The preset vibration threshold refers to a threshold set based on the statistical mean of a large amount of historical patient data. It is used to determine whether the laryngeal vibration signal reaches the triggering standard for a cough event. For example, the preset vibration threshold can be set to 0.5g (gravitational acceleration), but this is not limited in the embodiments of the present invention.

[0088] For example, in a single cough event, the intensity of the vibration signal exceeding the threshold can be quantified by calculating the difference between the amplitude of the laryngeal vibration signal and a preset vibration threshold, and then performing an absolute value operation to obtain a non-negative value.

[0089] The first mean refers to the arithmetic mean of the absolute values ​​of the differences between the laryngeal vibration signals corresponding to all cough events and the preset vibration threshold, which is used to characterize the average intensity of laryngeal vibration exceeding the threshold in all cough events.

[0090] Laryngeal pressure signal refers to signal data related to the patient's laryngeal pressure, which is collected by a laryngeal contact sensor and obtained after analog-to-digital conversion. It is the basis for judging cough events.

[0091] The preset pressure threshold refers to a threshold set based on the statistical mean of a large amount of historical patient data. It is used to determine whether the laryngeal pressure signal reaches the triggering standard for a cough event. For example, the preset pressure threshold can be set to 2 kPa, but this is not limited in the embodiments of the present invention.

[0092] For example, in a single cough event, the intensity of the pressure signal exceeding the threshold can be quantified by calculating the difference between the amplitude of the laryngeal pressure signal and a preset pressure threshold, and then performing an absolute value operation to obtain a non-negative value.

[0093] The second mean refers to the arithmetic mean of the absolute values ​​of the differences between the laryngeal pressure signals corresponding to all cough events and the preset pressure threshold, which is used to characterize the average intensity of laryngeal pressure exceeding the threshold in all cough events.

[0094] The target mean refers to the value obtained by adding the first mean and the second mean, which comprehensively quantifies the average intensity of laryngeal vibration and pressure exceeding the corresponding threshold in all cough events.

[0095] For example, taking cough events in the initial stage of nebulization as the statistical object, the average intensity (first mean and second mean) of the laryngeal vibration signal and laryngeal pressure signal exceeding the corresponding preset thresholds in all cough events is calculated, and then the two are summed to obtain the target mean, which provides data for subsequent calculation of the real-time stress index of the larynx in combination with the number of cough events.

[0096] The real-time stress level of the larynx was determined based on the number of cough events and the target mean.

[0097] The target mean refers to the sum of the absolute values ​​of the differences between the two types of signals in all cough events within the initial time T. This includes the mean of the absolute value of the difference between the laryngeal vibration signal and the preset vibration threshold, and the mean of the absolute value of the difference between the laryngeal pressure signal and the preset pressure threshold. This is used to quantify the signal intensity of each cough event.

[0098] The real-time laryngeal stress index refers to an index obtained by quantifying the intensity of the patient's laryngeal response to nebulization stimulation in the initial stage of nebulization. It is obtained by multiplying the number of cough events and the target mean and then performing min-max normalization. The larger the value, the stronger the stimulation to the patient's laryngeal region and the more obvious the stress response.

[0099] For example, within the initial preset time period of nebulization, the number of cough events of the patient is counted, and the target mean of the signal intensity corresponding to all cough events is calculated; then, the comprehensive stress effect of cough frequency and single intensity is quantified by multiplying the two, and after normalization, an index reflecting the intensity of the real-time stress response of the patient's larynx is finally obtained.

[0100] For example, the real-time stress level index of the larynx can be expressed as: ; in, This indicates the real-time stress level in the throat. This represents the normalization function (using the min-max normalization method). This indicates the number of cough events that occurred in the patient during the initial time T. This represents the sum of the absolute values ​​of the differences between the laryngeal vibration signal and its preset vibration threshold, and the absolute values ​​of the differences between the laryngeal pressure signal and its preset pressure threshold, across all cough events of the patient. The higher the value, the greater the real-time stress level in the patient's larynx.

[0101] Furthermore, after collecting real-time monitoring data, it also includes: An abnormal event is identified when the amplitude increase of the laryngeal signal in the laryngeal time sequence is greater than or equal to a preset increase; abnormal events include coughing events.

[0102] Among them, laryngeal signals refer to signals that reflect the patient's laryngeal activity, which are monitored by laryngeal contact sensors. Specifically, they include laryngeal vibration signals and laryngeal pressure signals, and can be used to determine laryngeal movements such as coughing and swallowing.

[0103] Signal amplitude refers to the intensity value of the larynx signal at a single statistical moment. It is an indicator of the intensity of larynx activity. The vibration signal amplitude increases significantly during coughing.

[0104] The preset increase refers to a judgment threshold preset based on clinical data, used to determine whether there are abnormal fluctuations in the laryngeal signal. For example, the preset increase can be 1 / 2 of the signal amplitude at the previous statistical time point, but it is not limited in the embodiments of the present invention.

[0105] Abnormal events refer to abnormal conditions in the patient's throat during nebulization, such as coughing events, which need to be determined by whether the signal amplitude increase reaches the preset standard.

[0106] For example, a throat time sequence (including vibration and pressure time sequence data) is collected and generated by a throat contact sensor. The throat signal amplitude is compared with the previous statistical time in real time. If the amplitude increase reaches or exceeds the preset increase, an abnormal event is determined to have occurred.

[0107] In the event of an abnormal event, an emergency control command is determined so that the nebulizer can output nebulized medication based on the emergency control command; the emergency control command is used to adjust the current nebulization flow rate to a preset safe nebulization flow rate value.

[0108] Among them, the emergency control command refers to the command generated after an abnormal event is detected, which is used to urgently adjust the operation of the nebulizer. It is used to quickly adjust the nebulization flow rate, avoid excessive stimulation of the patient's throat under abnormal conditions, and ensure the safety and comfort of the nebulization process.

[0109] Nebulized drug delivery refers to the process of converting the liquid medication in the drug storage tank into droplet-like aerosols through a nebulization unit such as an ultrasonic transducer, and then delivering it to the patient at a set flow rate for nebulization to achieve targeted treatment of the larynx.

[0110] The current nebulization flow rate refers to the nebulizer's output flow rate of nebulized aerosol at the moment the abnormal event occurs. This flow rate may no longer be suitable due to the patient's sudden condition and needs to be adjusted through emergency control commands.

[0111] The preset safe nebulization flow rate value refers to the pre-set safe flow rate benchmark value that needs to be switched to immediately when an abnormal event occurs. It is used to ensure the nebulization process continues with a low-irritation, high-safety flow rate and avoid risks when the patient experiences sudden discomfort.

[0112] For example, if the amplitude of the throat sensor signal exceeds the preset increase during the patient's nebulization process, an emergency control command will be generated immediately. This emergency control command can quickly adjust the current nebulization flow rate of the nebulizer to the preset safe nebulization flow rate value, thereby avoiding excessive stimulation of the patient's throat under abnormal conditions and ensuring the safety and continuity of the nebulization process.

[0113] It should be noted that after adjusting the nebulization flow rate to the preset safe nebulization flow rate value, monitoring data is continuously collected. Based on the monitoring data, the updated initial state normality index is determined. If the updated initial state normality index is greater than the preset normality index threshold, and the real-time throat stress index is lower than the safety threshold for a preset duration (e.g., 1 minute), the nebulization flow rate is controlled to slowly increase in preset steps (e.g., 0.5 ml / min) until the initial nebulization flow rate is reached.

[0114] The correction module 103 is used to correct the initial atomization flow rate based on the initial state normality index and the real-time throat stress index to obtain the corrected atomization flow rate.

[0115] The initial state normality index refers to an indicator that quantifies the stability and effectiveness of the nebulization process in the initial stage of nebulization, and is used to judge the suitability of the initial nebulization flow rate. It can be calculated based on the variance and average nebulization flow rate of the nebulization pressure time series data in this stage, combined with the initial nebulization flow rate and the effectiveness of historical patient nebulization flow rates. The higher the initial state normality index, the more normal the initial nebulization state and the better the initial flow rate suitability.

[0116] The real-time laryngeal stress index is an indicator that quantifies the intensity of the laryngeal stress response during the initial stage of nebulization, reflecting the laryngeal tolerance to the current nebulization conditions. It is determined by the number of cough events during this stage, combined with the average absolute value of the difference between the laryngeal vibration and pressure signals exceeding the corresponding preset thresholds in all cough events. A higher real-time laryngeal stress index value indicates a stronger laryngeal stress response.

[0117] The corrected nebulization flow rate refers to the final initial drug delivery flow rate after correction (subsequent iterative adjustments are based on this). Ensure that the flow rate adjustment is not lower than the effective threshold and is adapted to the patient's real-time condition.

[0118] For example, in an embodiment of the present invention, based on the initial state normality index and the real-time throat stress index, if the initial state normality index is less than the preset normality index threshold, a correction process will be initiated. By calculating the adjustment range, a corrected flow rate that ensures effective drug nebulization while avoiding excessive throat stimulation is obtained, providing a basis for the iteration of the subsequent nebulization process.

[0119] Furthermore, the initial nebulization flow rate is corrected based on the initial state normality index and the real-time throat stress index to obtain the corrected nebulization flow rate, including: Based on the initial state normality index, the real-time throat stress index, the flow rate adjustment coefficient, and the initial atomization flow rate, the adjusted atomization flow rate is determined; the flow rate adjustment coefficient is used to characterize the adjustable range benchmark of the initial atomization flow rate.

[0120] The flow rate adjustment coefficient is a preset fixed coefficient used to characterize the adjustable range of the initial nebulization flow rate. Its value determines the maximum potential range of flow rate adjustment and needs to be preset in combination with drug characteristics, clinical data, etc., to balance the effectiveness and safety of flow rate adjustment.

[0121] It should be noted that patients with a history of baseline respiratory status differences that are greater than or equal to a preset threshold will not be included in the calculation of the initial nebulization flow rate.

[0122] It should be noted that, in the embodiments of the present invention, the initial nebulization flow rate determined based on historical reference patients is used as the basis, combined with the initial state normality index and the real-time laryngeal stress index, and the adjustment range is limited by a preset flow rate adjustment coefficient, so as to finally calculate the adjustment of the nebulization flow rate and realize the correction of the initial flow rate.

[0123] The corrected atomization flow rate is determined based on the preset lower limit atomization flow rate threshold and the adjusted atomization flow rate.

[0124] Among them, the preset lower limit nebulization flow rate threshold refers to the minimum effective nebulization rate of the nebulizer preset by the doctor according to the characteristics of the drug. It is the lower limit of the flow rate to ensure that the drug can exert its therapeutic effect, and avoids the drug not being able to effectively deposit in the target area of ​​the throat due to the flow rate being too low, thus ensuring the basic effectiveness of the treatment.

[0125] Adjusting the nebulization flow rate refers to the baseline value for flow rate adjustment calculated based on the patient's initial nebulization state and the real-time stress level of the larynx, reflecting the required range of flow rate adjustment for the patient's real-time state.

[0126] The corrected nebulization flow rate refers to the final execution flow rate determined by adjusting the nebulization flow rate and combining it with a preset lower limit nebulization flow rate threshold. It is obtained by taking the maximum value of the adjusted nebulization flow rate and the preset lower limit nebulization flow rate threshold, which ensures that the flow rate is adapted to the patient's real-time laryngeal and respiratory status, and is not lower than the minimum effective flow rate required for treatment.

[0127] For example, the corrected atomization flow rate can be expressed as: ; in, This indicates the patient's corrected nebulization flow rate. This indicates the initial nebulization flow rate of the nebulizer for the current patient. This represents the function that takes the maximum value. This indicates the degree of normality of the patient's initial condition. This indicates the real-time stress level in the throat. This represents the preset flow rate adjustment coefficient. Furthermore, when... The higher the value, the greater the adjustment of the nebulizer's flow rate is needed to avoid excessive throat irritation for the patient. The preset lower limit nebulization flow rate threshold for the nebulizer (the minimum effective nebulization rate preset by the doctor based on the characteristics of the drug).

[0128] For example, the preset flow rate adjustment coefficient X is recommended to be in the range of 0.1 to 0.5.

[0129] For example, after setting the initial flow rate based on the patient's basic respiratory state, the nebulization flow rate is adjusted by combining the normality of the nebulization state in the initial stage of nebulization and the real-time stress level of the larynx; then, with a preset lower limit nebulization flow rate threshold as a constraint, the maximum value of the adjusted nebulization flow rate and the threshold is taken as the corrected nebulization flow rate.

[0130] The control module 104 is used to determine control commands based on the corrected atomization flow rate, so that the nebulizer outputs atomized medication based on the control commands.

[0131] Among them, the control command refers to the command generated by the intelligent control center to control the operation of the nebulizer. The nebulizer outputs nebulized drugs at the set flow rate through the transmission of the command.

[0132] It is important to emphasize that the control commands determined based on the modified nebulization flow rate are only used to drive the nebulizer to output nebulized medication that is adapted to the patient's current laryngeal state and inhalation status (usually a control command corresponding to the flow rate dynamically and iteratively adjusted based on real-time monitoring data, in order to reduce the irritation to the patient's throat caused by improper flow rate while ensuring effective drug deposition in the target area of ​​the larynx). This is to help improve the treatment effect and the patient's inhalation comfort. However, the final calibration of the nebulization flow rate, the optimization and adjustment of the control commands, and the improvement of subsequent treatment plans need to be determined by medical staff based on their own clinical experience, drug characteristics, and the patient's actual treatment response.

[0133] Furthermore, after determining the control command based on the modified atomization flow rate, it also includes: Within a preset sliding time window, the updated initial state normality index is determined based on the corrected atomization flow rate and real-time monitoring data.

[0134] The preset sliding time window refers to a fixed duration window (e.g., 1 minute) used to continuously monitor and assess the patient's condition during nebulization. The window slides continuously over time (i.e., after each unit of time, the window moves backward synchronously, always covering the latest 1-minute data), which is used to achieve iterative dynamic adjustment of the flow rate.

[0135] It should be noted that abnormal events refer to interruptive real-time responses (milliseconds), while sliding windows refer to trend-based periodic adjustments (minutes).

[0136] The updated initial state normality index refers to the index recalculated within each preset sliding time window based on real-time monitoring data and the current baseline flow rate (corrected nebulization flow rate or flow rate adjusted in the previous window), using the same calculation logic as the initial state normality index. It is used to assess the normality of the patient's nebulization state at the current flow rate in real time.

[0137] For example, during the atomization process, a fixed sliding time window of 1 minute is used. Based on the currently effective corrected atomization flow rate (or the flow rate adjusted in the previous window) and combined with the real-time monitoring data continuously collected within the window, the updated initial state normality index is recalculated.

[0138] Based on the updated initial state normality index and the preset normality index threshold, the atomization flow rate control strategy is determined, and the control command is updated based on the atomization flow rate control strategy.

[0139] The preset normality index threshold refers to the pre-set critical value for judging whether the atomization state is normal. It is the basis for distinguishing between maintaining the current flow rate and adjusting the flow rate. If the updated initial state normality index is greater than or equal to the preset normality index threshold, the atomization state is judged to be normal. If the updated initial state normality index is less than the preset normality index threshold, the atomization state is judged to be abnormal and the flow rate needs to be adjusted.

[0140] The atomization flow rate control strategy refers to the atomizer flow rate regulation scheme determined based on the comparison between the updated initial state normality index and the preset normality index threshold. Specifically, it includes maintenance strategy and adjustment strategy. In particular, if the increase in the amplitude of the throat sensor signal is greater than the preset increase, the flow rate needs to be adjusted to a safe value immediately and then slowly restored after the signal stabilizes.

[0141] Control commands refer to instructions generated by the atomizer's intelligent control center to control the operation of the micro-flow rate regulating valve. These commands include specific execution requirements such as maintaining the current flow rate, adjusting the flow rate according to the calculated value, and switching to a safe value. They are transmitted to the flow rate regulating component via wireless communication or a built-in chip to control the atomization flow rate.

[0142] For example, within a sliding time window, an updated initial state normality index is calculated based on real-time monitoring data within the window. This index is compared with a preset threshold to determine the corresponding nebulization flow rate control strategy (maintaining the current flow rate, adjusting the flow rate, or activating emergency measures). An updated control command is generated based on the determined strategy. After the feasibility of the updated control command is verified manually (by medical staff based on experience to determine whether to enable the updated control command), it is transmitted to the flow rate regulating valve for execution, ultimately achieving the regulation of the nebulization flow rate during nebulization, ensuring effective drug deposition and patient comfort.

[0143] Furthermore, based on the updated initial state normality index and the preset normality index threshold, the atomization flow rate control strategy is determined, including: If the updated initial state normality index is greater than or equal to the preset normality index threshold, the atomization flow rate control strategy is determined to maintain the corrected atomization flow rate.

[0144] It should be noted that, in the embodiments of the present invention, within the sliding time window, the updated initial state normality index is iteratively calculated; when the index is greater than or equal to a preset threshold, it indicates that the patient's current nebulization state is normal, and the corrected nebulization flow rate can adapt to the patient's throat and breathing state. At this time, the nebulization flow rate control strategy is determined to maintain the corrected nebulization flow rate, and a corresponding control command is generated. After the feasibility of the control command is verified manually (by medical staff based on experience to determine whether to enable the control command), it is then transmitted to the flow rate regulating valve for execution, so as to ensure the effective deposition of drugs and the stability of the patient's nebulization comfort.

[0145] If the updated initial state normality index is less than the preset normality index threshold, the atomization flow rate control strategy is determined to be the updated and corrected atomization flow rate, and the corrected atomization flow rate is updated based on the updated initial state normality index and the real-time throat stress index.

[0146] Among them, the updated and corrected atomization flow rate refers to the new adaptive flow rate obtained by adjusting the corrected flow rate at the previous moment during the iterative monitoring process, combining the updated initial state normality index and the real-time throat stress index. It is a parameter that ensures the adaptability of the subsequent atomization process.

[0147] For example, within the sliding time window, the updated initial state normality index is continuously calculated and compared with a preset normality index threshold. If the updated initial state normality index is less than the preset normality index threshold, it indicates that the current nebulization flow rate is not well adapted to the patient's real-time nebulization state. At this time, the flow rate control strategy is determined to be the updated and corrected nebulization flow rate. Combined with the updated initial state normality index and the real-time laryngeal stress index, the corrected flow rate of the previous moment is readjusted, and a corresponding control command is generated. After the feasibility of the updated control command is verified manually (by medical staff based on experience to determine whether to enable the updated control command), it is transmitted to the flow rate regulating valve for execution, ensuring that the nebulization flow rate always adapts to the patient's dynamic nebulization state, ensuring effective drug deposition and patient comfort.

[0148] In summary, this invention determines the initial nebulization flow rate appropriate to the individual's underlying condition by combining the patient's historical medical information. Then, based on real-time monitoring data such as nebulization time-series data and laryngeal time-series data, it constructs an initial state normality index and a real-time laryngeal stress index, and dynamically adjusts the nebulization flow rate accordingly, ultimately outputting control commands. This avoids the problem of traditional fixed or manual flow rate adjustments being difficult to adapt to individual differences, and can respond in real time to changes in the patient's respiratory status and laryngeal response. It effectively reduces laryngeal irritation caused by improper flow rate, improves treatment comfort, and ensures effective drug deposition in the laryngeal target area to optimize treatment effects, thus improving the accuracy of nebulization flow rate control.

[0149] It should be noted that the system provided in the above embodiments is only an example of the division of the above functional modules. In actual applications, the above functions can be assigned to different functional modules as needed, that is, the internal structure of the computer device can be divided into different functional modules to complete all or part of the functions described above.

[0150] In one embodiment, the present invention also provides a throat nebulizer and a method for intelligent flow rate control thereon, such as... Figure 2 As shown, the method includes: Step S1: Determine the patient's baseline respiratory status based on the patient's historical medical information, and determine the initial nebulization flow rate based on the baseline respiratory status; Step S2: Collect real-time monitoring data and determine the initial state normality index and the laryngeal real-time stress index based on the real-time monitoring data; the real-time monitoring data includes nebulization time series data and laryngeal time series data; the initial state normality index is used to characterize the adaptability of the initial nebulization flow rate setting; the laryngeal real-time stress index is used to characterize the laryngeal tolerance to the real-time nebulization flow rate. Step S3: Correct the initial atomization flow rate based on the initial state normality index and the real-time throat stress index to obtain the corrected atomization flow rate. Step S4: Determine the control command based on the corrected atomization flow rate so that the nebulizer outputs atomized medication based on the control command.

[0151] The throat nebulizer and its intelligent flow rate control system provided in the above embodiments belong to the same concept as the throat nebulizer and its intelligent flow rate control method. The specific implementation process is detailed in the system embodiments and will not be repeated here.

[0152] This invention also provides an electronic device. Please refer to [link to relevant documentation]. Figure 3 The electronic device may include a processor 301, a memory 302, and a program 3021 stored in the memory 302 and capable of running on the processor 301.

[0153] When program 3021 is executed by processor 301, it can achieve the following: Figure 2 Any steps in the corresponding method embodiments and the achievement of the same beneficial effects will not be repeated here.

[0154] Those skilled in the art will understand that all or part of the steps of the methods described in the above embodiments can be implemented by hardware related to program instructions, and the program can be stored in a readable medium.

[0155] This invention also provides a readable storage medium storing a computer program, which, when executed by a processor, can perform the above-described functions. Figure 2 Any step in the corresponding method embodiment can achieve the same technical effect, and will not be repeated here to avoid repetition.

[0156] The computer-readable storage medium of this invention can be any combination of one or more computer-readable media. The computer-readable medium can be a computer-readable signal medium or a computer-readable storage medium. For example, a computer-readable storage medium can be an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination thereof. More specific examples of computer-readable storage media (a non-exhaustive list) include: an electrical connection having one or more wires, a portable computer disk, a hard disk, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), optical fiber, portable compact disk read-only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination thereof. In this document, a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

[0157] Computer-readable signal media may include data signals propagated in baseband or as part of a carrier wave, carrying computer-readable program code. Such propagated data signals may take various forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination thereof. Computer-readable signal media may also be any computer-readable medium other than computer-readable storage media, capable of sending, propagating, or transmitting programs for use by or in connection with an instruction execution system, apparatus, or device.

[0158] The program code contained on the storage medium can be transmitted using any suitable medium, including but not limited to wireless, wire, optical fiber, RF, etc., or any suitable combination thereof.

[0159] Computer program code for performing the operations of this invention can be written in one or more programming languages ​​or a combination thereof, including object-oriented programming languages ​​such as Java, Smalltalk, and C++, as well as conventional procedural programming languages ​​such as "C" or similar programming languages. The program code can be executed entirely on the user's computer, partially on the user's computer, as a standalone software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or terminal. In cases involving remote computers, the remote computer can be connected to the user's computer via any type of network—including a local area network (LAN) or a wide area network (WAN)—or can be connected to an external computer (e.g., via the Internet using an Internet service provider).

[0160] This invention also provides a computer program product that, when run on a computer, causes the computer to perform the aforementioned steps to realize the throat nebulizer and its intelligent flow rate control method provided in the above embodiments.

[0161] It should be noted that the order of the above embodiments of the present invention is merely for descriptive purposes and does not represent the superiority or inferiority of the embodiments. The processes depicted in the accompanying drawings do not necessarily require a specific or sequential order to achieve the desired result. In some embodiments, multitasking and parallel processing are also possible or may be advantageous.

[0162] The various embodiments in this specification are described in a progressive manner. The same or similar parts between the various embodiments can be referred to each other. Each embodiment focuses on describing the differences from other embodiments.

Claims

1. A throat medication nebulizer and its intelligent flow rate control system, characterized in that, The system includes: The initial state determination module is used to determine the patient's baseline respiratory state based on the patient's historical medical information, and to determine the initial nebulization flow rate based on the baseline respiratory state. The data processing module is used to collect real-time monitoring data and determine the initial state normality index and the laryngeal real-time stress index based on the real-time monitoring data; the real-time monitoring data includes nebulization time series data and laryngeal time series data; the initial state normality index is used to characterize the adaptability of the initial nebulization flow rate setting; the laryngeal real-time stress index is used to characterize the laryngeal tolerance to the real-time nebulization flow rate. The correction module is used to correct the initial atomization flow rate based on the initial state normality index and the real-time throat stress index to obtain the corrected atomization flow rate. The control module is used to determine control commands based on the corrected atomization flow rate, so that the nebulizer outputs atomized medication based on the control commands.

2. The throat nebulizer and its intelligent flow rate control system according to claim 1, characterized in that, Determining the patient's baseline respiratory status based on the patient's historical medical history includes: Obtain the number of disease keywords and the number of visits related to medical treatment from the historical medical records; Based on preset coefficients, the number of disease-related keywords and the number of medical visits are weighted and summed to determine the patient's baseline respiratory status.

3. The throat nebulizer and its intelligent flow rate control system according to claim 2, characterized in that, The determination of the initial nebulization flow rate based on the basic respiratory state includes: The absolute value of the difference in baseline respiratory status is determined based on the patient's baseline respiratory status and the baseline respiratory status of historical patients. Based on the absolute value of the difference in baseline respiratory status and a preset threshold, at least one reference historical patient is identified; The initial nebulization flow rate of the patient is determined based on the mean of the initial nebulization flow rates of at least one of the reference historical patients.

4. The throat nebulizer and its intelligent flow rate control system according to claim 1, characterized in that, The atomization time-series data includes atomization pressure time-series data and atomization flow rate time-series data. The step of determining the initial state normality index based on the real-time monitoring data includes: The initial stable value of atomization pressure is determined based on the variance of the atomization pressure time series data within a preset time period; The average nebulization flow rate of the patient is determined based on the average value of the nebulization flow rate time sequence data within the preset time period; The initial state normality index is determined based on the initial stable atomization pressure value, the average atomization flow rate, and the initial atomization velocity.

5. The throat nebulizer and its intelligent flow rate control system according to claim 1, characterized in that, The laryngeal time series includes a laryngeal vibration time series and a laryngeal pressure time series. The determination of the real-time laryngeal stress level index based on the real-time monitoring data includes: Based on the laryngeal time sequence within a preset time period and a preset trigger threshold, the cough events and the number of cough events are determined; The target mean is determined by the sum of the first mean of the absolute values ​​of the differences between the laryngeal vibration signal corresponding to the cough event and the preset vibration threshold, and the second mean of the absolute values ​​of the differences between the laryngeal pressure signal corresponding to the cough event and the preset pressure threshold. Based on the number of cough events and the target mean, an index of real-time laryngeal stress level is determined.

6. The throat nebulizer and its intelligent flow rate control system according to claim 1, characterized in that, The step of correcting the initial nebulization flow rate based on the initial state normality index and the real-time throat stress index to obtain the corrected nebulization flow rate includes: Based on the initial state normality index, the real-time throat stress index, the flow rate adjustment coefficient, and the initial atomization flow rate, the adjusted atomization flow rate is determined; the flow rate adjustment coefficient is used to characterize the adjustable range benchmark of the initial atomization flow rate. The corrected atomization flow rate is determined based on the preset lower limit atomization flow rate threshold and the adjusted atomization flow rate.

7. The throat nebulizer and its intelligent flow rate control system according to claim 1, characterized in that, Following the determination of the control command based on the modified atomization flow rate, the method further includes: Within a preset sliding time window, based on the corrected atomization flow rate and the real-time monitoring data, the updated initial state normality index is determined. Based on the updated initial state normality index and the preset normality index threshold, atomization flow rate control strategy is determined, and the control command is updated based on the atomization flow rate control strategy.

8. The throat nebulizer and its intelligent flow rate control system according to claim 7, characterized in that, The step of determining the atomization flow rate control strategy based on the updated initial state normality index and the preset normality index threshold includes: If the updated initial state normality index is greater than or equal to the preset normality index threshold, the atomization flow rate control strategy is determined to maintain the corrected atomization flow rate. If the updated initial state normality index is less than the preset normality index threshold, the atomization flow rate control strategy is determined to be to update the corrected atomization flow rate, and the corrected atomization flow rate is updated according to the updated initial state normality index and the real-time throat stress index.

9. The throat nebulizer and its intelligent flow rate control system according to claim 1, characterized in that, Following the collection of real-time monitoring data, the following is also included: An abnormal event is identified when the amplitude increase of the laryngeal signal in the laryngeal time sequence is greater than or equal to a preset increase; the abnormal event includes a coughing event. In the event of the aforementioned abnormal event, an emergency control command is determined so that the nebulizer outputs nebulized medication based on the emergency control command; the emergency control command is used to adjust the current nebulization flow rate to a preset safe nebulization flow rate value.

10. The throat nebulizer and its intelligent flow rate control system according to claim 1, characterized in that, The system also includes: The information acquisition module is used to acquire the number of disease keywords and the number of times related to medical visits in the historical medical information; The respiratory status determination module is used to determine the patient's baseline respiratory status by weighted summing of the number of disease keywords and the number of medical visits based on preset coefficients.

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