Synthesis method of deuterated 1-naphthyl-9-anthracene-D9

CN122010658APending Publication Date: 2026-05-12PERRY TECH CO LTD
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PERRY TECH CO LTD
Filing Date
2025-12-30
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

In the existing technology for synthesizing deuterated 9-bromoanthracene, the hydrogen-deuterium exchange effect of the palladium catalyst leads to a significant decrease in the deuteration rate, which affects the quality of the target product.

Method used

Using 1-naphthylboronic acid and deuterated 9-bromoanthracene as raw materials, and Pd(PPh3)4 or Pd(PPh3)2Cl2 as catalysts, the Suzuki coupling reaction was carried out in an alkaline environment of potassium phosphate, and the temperature was controlled at 50-80℃. The raw material ratio and purification steps were optimized.

Benefits of technology

High deuteration rate and high yield were achieved in the presence of palladium catalyst. The deuteration rate of the prepared pure 1-naphthyl-9-anthracene-D9 was above 97.5%, the yield was above 84%, and the purity was above 99.3%, which improved the quality of the product.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122010658A_ABST
    Figure CN122010658A_ABST
Patent Text Reader

Abstract

The invention belongs to the technical field of deuterated organic chemical synthesis, and particularly relates to a synthetic method of deuterated 1-naphthyl-9-anthracene-D9, which comprises the following steps: taking 1-naphthylboronic acid and deuterated 9-bromoanthracene as raw materials, taking Pd (PPh3) 4 or Pd (PPh3) 2Cl2 as a catalyst, and carrying out Suzuki coupling reaction at the temperature of 50-80 DEG C in a potassium phosphate alkaline environment to prepare the deuterated 1-naphthyl-9-anthracene-D9. According to the synthesis method provided by the invention, the 1-naphthylboronic acid and the deuterated 9-bromoanthracene react in the alkaline environment under the catalysis condition of the palladium catalyst to generate the 1-naphthyl-9-anthracene-D9, so that the reduction of the deuteration rate is avoided, and the obtained product has high yield, high deuteration rate and high purity at the same time.
Need to check novelty before this filing date? Find Prior Art