Light sheet microscope sample pool

The modular design of the side and bottom connectors ensures high-precision concentric installation of the curved side window and detachability of the light-transmitting components, solving the problems of aberration and cumbersome operation in existing technologies and achieving efficient high-resolution imaging.

CN122016657APending Publication Date: 2026-05-12GUANGYUAN TECH (SHENZHEN) CO LTD
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Patent Information

Application Number
CN202610170539.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-06
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

In existing inverted lens microscope systems, the curved side window and bottom window are fixed by adhesive bonding in the sample cell, which makes it difficult to achieve high-precision concentricity, resulting in aberrations in the illumination optical path. Furthermore, the bottom window cannot be replaced individually to adapt to different optical requirements, making the operation cumbersome and increasing costs.

Method used

The side and bottom connectors feature a modular design. The side connectors can be detachably fitted with curved side windows, while the bottom connectors can be detachably fitted with light-transmitting components. Precise positioning is ensured by axial stoppers and circumferential anti-rotation components. The light-transmitting components use a glass bottom window and a light-transmitting film made of PDMS. The connectors use threaded connections instead of adhesive bonding.

Benefits of technology

It improves the focusing accuracy of illumination light, avoids aberration problems, simplifies the replacement process of curved side windows, reduces usage costs, and provides a stable high-resolution imaging environment.

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Abstract

The invention relates to the technical field of sample pools for light sheet microscopes, and discloses a light sheet microscope sample pool, which comprises a box body used for placing a sample, at least one side surface of the box body is provided with a first mounting hole, and the bottom of the box body is provided with a second mounting hole; at least one side surface connector, wherein each side surface connector is provided with a curved surface side window; the bottom connector is provided with a light transmitting piece; the side connector is detachably mounted in the first mounting hole, and the curved-surface side window is fixed on the side connector to replace a traditional bonding process, so that the curved-surface side window is convenient to replace, high-precision concentric mounting of the curved-surface side window is ensured, the bottom connector is detachably mounted, the bottom connectors with various height specifications can be arranged, and the mounting efficiency is improved. Different detection objective lenses have different working distance requirements, and the bottom connector with the corresponding height specification can be conveniently replaced in observation to adapt to the working distance of the detection objective lens without replacing the whole sample pool.
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