Equipment inspection device and calibration method for near-infrared brain function imaging device

Abstract

The invention discloses an equipment inspection device and calibration method for a near-infrared brain function imaging device.The equipment inspection device comprises a first medium, at least two second media and at least two apertures, the two ends of the first medium are connected with an incident end and an output end, the incident end is used for emitting near-infrared light, the second media are embedded in the first medium, and the output end is used for outputting the near-infrared light. The first medium and the second medium are respectively used for absorbing near-infrared light with corresponding wavelengths and scattering near-infrared light with other wavelengths, each aperture is embedded in the first medium, the number of the apertures is the same as that of the second medium, each aperture is respectively arranged at a scattering path of the corresponding first medium so as to receive and conduct the scattered near-infrared light to the output end, and the aperture is arranged in the scattering path of the second medium. The aperture of the aperture can be adjusted so as to form a standard reference object which plays a role in equipment inspection and waveform calibration, and the product inspection efficiency and accuracy are improved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a device testing apparatus and calibration method for a near-infrared brain functional imaging device. Background Technology

[0002] Functional near-infrared spectroscopy (fNIRS) utilizes the absorption and scattering relationships between near-infrared light of multiple wavelengths and chromophores (such as oxyhemoglobin and deoxyhemoglobin) in brain tissue to examine changes in the concentration of these substances under specific conditions. These concentration changes can indirectly reflect neuronal activity, cellular energy metabolism, and hemodynamic-related functions, thereby revealing the state and processing of the brain. Specifically, when the brain is active, the oxygen content of blood in active areas increases, leading to an increase in the concentration of oxyhemoglobin in the cortex and a decrease in the concentration of deoxyhemoglobin. These changes affect the propagation of light in brain tissue and are thus captured by near-infrared brain functional imaging equipment. By analyzing these changes in light, the brain's activity can be inferred.

[0003] Near-infrared brain functional imaging devices collect dynamic changes in brain blood oxygenation. Currently, there is no available data calibration and verification method. During the equipment's factory testing process, each light source in different channels is usually tested separately, which is a cumbersome process. Summary of the Invention

[0004] The purpose of this invention is to address the technical problems existing in the background art by proposing a device testing apparatus for near-infrared brain functional imaging devices.

[0005] To achieve the above-mentioned technical objectives, the technical solution adopted by the present invention in the first aspect is as follows: A device testing apparatus for a near-infrared brain functional imaging device is installed inside a housing. It includes a first medium, at least two second media, and at least two apertures. The first medium has an incident end and an output end connected to its two ends. The incident end is used to emit near-infrared light. Each second medium is embedded in the first medium to absorb near-infrared light of a corresponding wavelength and scatter near-infrared light of other wavelengths, respectively. Each aperture is embedded in the first medium, and the number of apertures is the same as the number of second media. Each aperture is placed at the scattering path of the corresponding first medium to receive and transmit the scattered near-infrared light to the output end. The aperture of the aperture is adjustable.

[0006] Preferably, the device testing apparatus for the near-infrared brain functional imaging device further includes a spectral phantom, in which the first medium, each of the second media, and the aperture are encapsulated.

[0007] Preferably, the spectral phantom is made of an opaque material.

[0008] Preferably, each of the second media is of the same size and is arranged side by side and close together to form a total attenuation medium.

[0009] Preferably, the length of the total attenuation medium is the same as the width of the first medium.

[0010] Preferably, there are two second media, and the two second media absorb two different wavelengths of near-infrared light.

[0011] Preferably, the device testing apparatus for the near-infrared brain functional imaging device further includes a support member, on which each aperture is mounted, and the support member places each aperture at the scattering path of the corresponding second medium.

[0012] Preferably, the support component is made of an opaque material.

[0013] Preferably, the first medium is a POM material with 50% white transparency.

[0014] The technical solution adopted in the second aspect of this invention is as follows: A calibration method is provided for a device testing apparatus of a near-infrared brain functional imaging device according to any of the above-mentioned schemes. The calibration method is as follows: Connect the incident end to a preset near-infrared light emission source and the output end to a preset standard cerebral blood oxygen acquisition device. Using a near-infrared light emission source, near-infrared light with different wavelengths is incident from the incident end into the first medium; Then, standard cerebral oxygenation equipment is used to collect near-infrared light of various wavelengths through the first medium, the second medium, and the aperture; And determine whether the waveform data of near-infrared light at each wavelength is consistent with the standard data built into the standard cerebral oxygenation acquisition device; If they are inconsistent, adjust the aperture of the corresponding aperture and then re-execute the standard brain blood oxygen acquisition and analysis operation. If they match, then the recommendations and calibration of the equipment testing device for the infrared brain functional imaging device are completed.

[0015] Compared with the prior art, the invention has the following beneficial technical effects: it includes a first medium, at least two second media, and at least two apertures. The first medium has an incident end and an output end connected to its two ends. The incident end is used to emit near-infrared light. Each second medium is embedded in the first medium to absorb near-infrared light of a corresponding wavelength and scatter near-infrared light of other wavelengths, respectively. Each aperture is embedded in the first medium, and the number of apertures is the same as the number of second media. Each aperture is placed at the scattering path of the corresponding first medium to receive and transmit the scattered near-infrared light to the output end. The aperture of the aperture can be adjusted to establish a standard reference, which can play a role in equipment inspection and waveform calibration, thereby improving the efficiency and accuracy of product inspection. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of an embodiment of the first aspect of the present invention; Figure 2 This is a calibration flowchart of an embodiment of the second aspect of the present invention; Figure 3 The graph shows the different absorption rates of brain oxygenated hemoglobin HbO2 and brain deoxygenated hemoglobin HbR under different wavelengths of near-infrared light in an optical window. Figure 4 The standard brain blood oxygenation waveform, brain oxygenated hemoglobin (HbO2) waveform, and brain deoxygenated hemoglobin (HbR) waveform are used to simulate brain blood oxygenation curves by converting waveform change data into aperture area changes.

[0017] Icon labels: 100 First medium, 200 Second medium, 300 Aperture, 301 Support, 400 Spectral phantom, 401 Incident end, 402 Output end. Detailed Implementation

[0018] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other.

[0019] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or assembly referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more features. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0020] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a link, or a specific connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the connection within two groups. Those skilled in the art will understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0021] The specific embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0022] like Figure 1-4 As shown, the present invention provides a device testing apparatus for a near-infrared brain functional imaging device in a first aspect, comprising a first medium 100, at least two second media 200 and at least two apertures 300; The first medium 100 has an incident end 401 and an output end 402 connected at both ends. The incident end 401 is used to emit near-infrared light. Each second medium 200 is embedded in the first medium 100 to absorb near-infrared light of the corresponding wavelength and scatter near-infrared light of other wavelengths, respectively. Each aperture 300 is embedded in the first medium 100. The number of apertures 300 is the same as the number of second mediums 200. Each aperture 300 is placed at the scattering path of the corresponding first medium 100 to receive and conduct the scattered near-infrared light to the output end 402. The aperture of the aperture 300 is adjustable.

[0023] like Figure 1As shown, the first medium 100 is the main body, and the second mediums 200 and the apertures 300 are spliced ​​together and embedded in the first medium 100. In this embodiment, the embedding position of the second mediums 200 and the apertures 300 is in the center of the first medium 100, so that the first medium 100 is divided into left and right parts. Of course, the embedding position of the second mediums 200 and the apertures 300 can be determined according to the actual application scenario or the needs of the user, so as to change the refraction path of the near-infrared light in the left and right parts of the first medium 100. However, there is no requirement for this in this embodiment, so it is preferred to embed them in the center. The structure consisting of the first medium 100, each of the second media 200, and each aperture 300 makes the light path pass sequentially through the left part of the first medium 100, each of the second media 200, each aperture 300, and finally the right part of the first medium 100. Each of the second media 200 is used to absorb near-infrared light of a specific wavelength and refract near-infrared light of other wavelengths to simulate different conditions of cerebral blood oxygenation by near-infrared light. The aperture adjustment of the aperture 300 is to control the intensity of the near-infrared light refracted into the first medium 100, so as to simulate the change of cerebral blood oxygenation by the change of aperture area. like Figure 3 As shown, according to the modified Beer-Lambert formula for calculating cerebral oxygenation, we can conclude that: ; ; Wherein, the extinction coefficient ε and the differential path factor DPF are fixed values, ΔOD is the change in near-infrared light, λ1 and λ2 are two different wavelengths of near-infrared light, and L is the optical path length.

[0024] Furthermore, there are two second media 200, and the two second media 200 absorb two different wavelengths of near-infrared light.

[0025] As described above, in this embodiment, two second media 200 with different absorption rates for near-infrared light of different wavelengths are used, so that these two second media 200 can simulate the state of brain oxygenated hemoglobin HbO2 and brain deoxygenated hemoglobin HbR under two different wavelengths of near-infrared light.

[0026] Furthermore, the device testing apparatus for the near-infrared brain functional imaging device also includes a spectral phantom 400, which encapsulates the first medium 100, each of the second media 200 and the aperture 300.

[0027] The Spectral Phantom 400 is made of opaque material.

[0028] Specifically, in order to ensure the safety of the entire near-infrared brain functional imaging device and to prevent near-infrared light from spilling out, an opaque spectral phantom 400 is added to the outer layer of the entire device.

[0029] Furthermore, each of the second media 200 is of the same size, and the second media 200 are arranged side by side and close together to form a total attenuation medium.

[0030] The length of the total attenuation medium is the same as the width of the first medium 100.

[0031] Specifically, to prevent near-infrared light from overflowing from the first medium 100 into the spectral phantom 400, or from overflowing from the total attenuation medium into the spectral phantom 400, thus affecting the accuracy of testing and calibration, the first medium 100 and the total attenuation medium are joined in a regular rectangular structure, so that most of the near-infrared light entering the left part of the first medium 100 can be absorbed or received by the total attenuation medium.

[0032] Furthermore, the equipment testing device of the near-infrared brain functional imaging device also includes a support 301, on which each aperture 300 is mounted, and the support 301 places each aperture 300 at the scattering path of the corresponding second medium 200.

[0033] Support component 301 is made of opaque material.

[0034] Furthermore, the first medium 100 is made of POM material with 50% white transparency.

[0035] In a second aspect, the present invention provides a calibration method for use in a device testing apparatus for a near-infrared brain functional imaging device according to any of the above-described embodiments. The calibration method includes: S1. Connect the incident end 401 to a preset near-infrared light emission source and the output end 402 to a preset standard cerebral blood oxygen acquisition device. S2. Using a near-infrared light emission source, near-infrared light with different wavelengths is emitted from the incident end 401 into the first medium 100; S3. Then, use a standard cerebral oxygenation acquisition device to collect near-infrared light of various wavelengths through the first medium 100, the second medium 200, and the aperture 300. S4. Determine whether the waveform data of each wavelength of near-infrared light is consistent with the standard data built into the standard cerebral oxygenation acquisition device. S5. If inconsistent, adjust the aperture of the corresponding aperture 300 and then re-execute the standard brain blood oxygen acquisition and analysis operation. S6. If consistent, then complete the recommendations and calibration of the equipment inspection device for the infrared brain functional imaging device.

[0036] The above descriptions provide one or more embodiments in conjunction with specific details, but do not imply that the specific implementation of the present invention is limited to these descriptions. Any methods or structures that are similar to or identical to those of the present invention, or any technical deductions or substitutions made based on the concept of the present invention, should be considered within the scope of protection of the present invention.

Claims

1. A device testing apparatus for a near-infrared brain functional imaging device, characterized in that, include: A first medium (100) has an incident end (401) and an output end (402) connected at both ends. The incident end (401) is used to emit near-infrared light. At least two second media (200), each second media (200) is embedded in the first medium (100) to absorb near-infrared light of the corresponding wavelength and scatter near-infrared light of other wavelengths, respectively; At least two apertures (300) are embedded in the first medium (100). The number of apertures (300) is the same as the number of the second medium (200). Each aperture (300) is placed at the scattering path of the corresponding first medium (100) to receive and conduct the scattered near-infrared light to the output end (402). The aperture of each aperture (300) is adjustable.

2. The equipment testing device for a near-infrared brain functional imaging device according to claim 1, characterized in that, It also includes a spectral phantom (400) that encapsulates the first medium (100), each of the second media (200) and the aperture (300).

3. The equipment testing device for a near-infrared brain functional imaging device according to claim 2, characterized in that, The spectral phantom (400) is made of opaque material.

4. The equipment testing device for a near-infrared brain functional imaging device according to claim 2, characterized in that, Each of the second media (200) is of the same size and is arranged side by side and close together to form a total attenuation medium.

5. The equipment testing device for a near-infrared brain functional imaging device according to claim 4, characterized in that, The length of the total attenuation medium is the same as the width of the first medium (100).

6. The equipment testing device for a near-infrared brain functional imaging device according to claim 4, characterized in that, There are two second media (200), and the two second media (200) absorb two different wavelengths of near-infrared light.

7. The equipment testing device for a near-infrared brain functional imaging device according to claim 2, characterized in that, It also includes a support member (301), on which each of the apertures (300) is mounted, and the support member (301) places each of the apertures (300) at the scattering path of the corresponding second medium (200).

8. The equipment testing device for a near-infrared brain functional imaging device according to claim 7, characterized in that, The support component (301) is made of opaque material.

9. The equipment testing device for a near-infrared brain functional imaging device according to claim 1, characterized in that, The first medium (100) is made of POM material with 50% white transparency.

10. A calibration method, characterized in that, The calibration method for the device testing apparatus of a near-infrared brain functional imaging device as described in any one of claims 1-9 includes: The incident end (401) is connected to a preset near-infrared light emission source, and the output end (402) is connected to a preset standard cerebral blood oxygen acquisition device. Using the near-infrared light emission source, near-infrared light with different wavelengths is emitted from the incident end (401) into the first medium (100); The standard cerebral blood oxygenation acquisition device is then used to collect near-infrared light of various wavelengths passing through the first medium (100), the second medium (200), and the aperture (300); And determine whether the waveform data of the near-infrared light at each wavelength is consistent with the standard data built into the standard cerebral oxygenation acquisition device; If they are inconsistent, adjust the aperture (300) corresponding to the aperture (300) and then re-execute the standard brain blood oxygen acquisition device acquisition and analysis operation; If they match, then the recommendations and calibration of the equipment inspection device for the infrared brain functional imaging device are completed.

Images