Preparation method and application of metal oxide hybrid hollow polydopamine microspheres

By preparing hollow polydopamine microspheres hybridized with metal oxides, the problems of structural instability and insufficient responsiveness of polydopamine microspheres in the blood circulation process were solved, achieving specific release and efficient delivery of drugs, which is suitable for integrated tumor diagnosis and treatment.

CN122075432APending Publication Date: 2026-05-26LUOYANG INST OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LUOYANG INST OF SCI & TECH
Filing Date
2026-01-12
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing polydopamine microspheres, as drug carriers, have poor structural stability during blood circulation, are prone to swelling and rupture, leading to premature drug leakage, and lack tumor microenvironment responsiveness, resulting in nonspecific drug delivery and low drug loading.

Method used

Using sulfonated polystyrene microspheres as hard templates, metal ions and dopamine are adsorbed through electrostatic interaction to form a metal oxide hybrid core-shell structure. Hollow polydopamine microspheres with metal oxide hybrids are prepared by hydrothermal reaction and dialysis technology to enhance structural stability and endow the tumor microenvironment with responsiveness.

Benefits of technology

It achieves specific release and efficient delivery of drugs, avoids toxic side effects caused by premature drug release, improves drug loading and delivery efficiency, and is suitable for the integrated diagnosis and treatment of tumors.

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Abstract

The invention relates to the technical field of chemical biological medicines, in particular to a preparation method and application of metal oxide hybrid hollow polydopamine microspheres. PSS is used as a hard template, metal ions and dopamine are adsorbed through static electricity, non-adsorbed metal ions are removed through dialysis, then the metal ions are oxidized into metal oxides through hydrothermal treatment, meanwhile, dopamine is subjected to self-polymerization to form polydopamine, and the composite material with the PSS as a core and the PDA as a shell is formed. A polydopamine-based core-shell structure with uniform size and controllable morphology of metal oxide particles is embedded, a hollow structure is formed along with etching of PSS and metal oxide, and a hollow structure with a nano plug is formed along with secondary coordination nucleation of metal ions after drug loading; due to the existence of the metal oxide, the stability of the adjustable structure of the prodrug is enhanced; the huge cavity structure is beneficial for increasing the drug loading capacity and the packaging efficiency of the anti-tumor small molecule drug; the composite material can realize directional delivery and efficient release of drugs.
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