A flexible patch for nervous system diseases and a preparation method thereof

By using a flexible intranasal patch loaded with levodopa and copper oxide nanozymes on a silk fibroin nanofiber substrate, the problems of blood drug concentration fluctuations and oxidative stress caused by traditional drug delivery methods have been solved. This has enabled continuous dopamine delivery and reactive oxygen species clearance, improving Parkinson's symptoms and slowing disease progression.

CN122075447APending Publication Date: 2026-05-26NANJING UNIV OF POSTS & TELECOMM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF POSTS & TELECOMM
Filing Date
2026-02-13
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing oral and intranasal drug delivery methods suffer from significant fluctuations in blood drug concentrations and frequent motor complications during administration. Furthermore, they cannot effectively intervene in oxidative stress, a key mechanism of Parkinson's disease. Existing intranasal delivery systems cannot achieve a combination of long-term retention, stable drug release, and antioxidant function.

Method used

A flexible nasal patch was prepared by loading drug-loaded nanoparticles containing levodopa and copper oxide nanozymes onto a flexible, breathable substrate made of silk fibroin nanofibers and encapsulating them with chitosan. The patch achieved close adhesion to the nasal mucosa by utilizing humidity responsiveness, and the drug release kinetics were regulated by ethanol annealing treatment.

Benefits of technology

It achieves continuous and stable dopamine delivery and simultaneous clearance of reactive oxygen species, significantly improves Parkinson's symptoms, slows disease progression, has good biocompatibility and patient compliance, avoids fluctuations in blood drug concentration and nasal irritation, and provides long-lasting, stable drug delivery and synergistic therapeutic effects.

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Abstract

This invention relates to the field of biomedical materials technology, and more particularly to a flexible patch for treating nervous system diseases and its preparation method. It comprises: a flexible, breathable substrate composed of silk fibroin nanofibers, and drug-loaded nanoparticles loaded within the substrate; the drug-loaded nanoparticles are encapsulated with chitosan and contain levodopa and copper oxide nanoenzymes; the silk fibroin nanofibers are annealed with ethanol to form a controllable degradation structure, achieving self-adhesion and continuous drug release in a humid environment. This patch can simultaneously achieve stable delivery of dopamine and scavenging of reactive oxygen species, thus addressing the motor complications and neurooxidative damage caused by fluctuations in blood drug concentration in traditional Parkinson's disease treatment, achieving a dual synergistic treatment of symptom relief and neuroprotection.
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