Oral care products and compositions thereof

Abstract

Disclosed herein are oral care compositions suitable for being dispensed with a pump and oral care products comprising an oral care composition and having a pump for dispensing such oral care composition. According to one aspect, there is provided an oral care product comprising: a container comprising a body defining a chamber and a pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: from about 36 wt% to about 72 wt% of a polyol system; a thickening system comprising from about 0.4 wt% to about 2.6 wt% of a silica thickening agent, a natural gum and a cellulose; one or more surfactants; and from about 10 wt% to about 36 wt% of water, wherein all weight percents are based on the total weight of the oral care composition.

Description

Technical Field

[0001] The present invention relates to oral care compositions suitable for dispensing with a pump, and oral care products comprising oral care compositions and having a pump for dispensing such oral care compositions. Background Technology

[0002] Many toothpaste products on the market are packaged in flexible tubes. While many consumers are satisfied with toothpaste packaged in flexible tubes, such products may exhibit certain drawbacks, including difficulty in squeezing for some users, difficulty for young children to control the amount of toothpaste dispensed, and the potentially unappealing appearance of the deformed tube. Furthermore, the frequent opening and closing of the cap can be inconvenient for young children. Summary of the Invention

[0003] This summary is intended only to provide a brief overview of some aspects of one or more embodiments of the present disclosure. Other applicable areas of the present disclosure will become apparent from the detailed description provided below. This summary is not an exhaustive overview, nor is it intended to identify key or essential elements of the teachings, nor to describe the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in a simplified form as a prelude to the following detailed description.

[0004] This invention relates to oral care compositions suitable for dispensing with a pump, and to oral care products comprising an oral care composition and a pump for dispensing such an oral care composition. According to one aspect of the invention, an oral care product is provided, the oral care product comprising: a container including a body defining a chamber and a pump extending into the chamber of the body; and an oral care composition disposed within the chamber, the oral care composition comprising: about 36 wt% to about 72 wt% of a polyol system; a thickening system comprising about 0.4 wt% to about 2.6 wt% of a silica thickener, natural gum and cellulose; one or more surfactants; and about 10 wt% to about 36 wt% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0005] According to another aspect, an oral care product is provided, the oral care product comprising: a container including a body defining a chamber and a pump extending into the chamber of the body; and an oral care composition disposed in the chamber, the oral care composition comprising: about 41 wt% to about 67 wt% of a polyol; a thickening system consisting of about 0.4 wt% to about 2.6 wt% of a silica thickener, xanthan gum and carboxymethyl cellulose, wherein xanthan gum and carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2:1; and one or more surfactants, said one or more surfactants including betaine surfactants; and about 13 wt% to about 26 wt% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0006] According to another aspect, an oral care composition suitable for dispensing using a pump is provided, the oral care composition comprising about 36% to about 72% by weight of a polyol system; a thickening system comprising about 0.4% to about 2.6% by weight of a silica thickener, natural gum and cellulose; one or more surfactants; and about 10% to about 36% by weight of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0007] According to yet another aspect, an oral care composition is provided for use in oral care products with pumps to reduce pump clogging, the oral care composition comprising: about 36% to about 72% by weight of a polyol system; a thickening system comprising about 0.4% to about 2.6% by weight of a silica thickener, natural gum, and cellulose; one or more surfactants; and about 10% to about 36% by weight of water, wherein all weight percentages are based on the total weight of the oral care composition. Preferably, the oral care composition disclosed herein has an instability index of 0.04 or less, more preferably about 0.025 or less, and even more preferably about 0.02 or less, as measured by the Lumisizer test. The Lumisizer analytical centrifugation test (also referred to herein as the “Lumisizer test”) is a test method designed to predict gravity-driven separation of toothpaste formulations within their expected shelf life. Typically, an instability index of 0.05 or less indicates a shelf life of at least 2 years. Attached Figure Description

[0008] Implementation of this technology will now be described by way of example only, with reference to the accompanying drawings, wherein:

[0009] Figure 1 This is a schematic diagram of an exemplary, non-limiting oral care product according to aspects of the present invention;

[0010] Figure 2This is a diagram illustrating a cross-section of an exemplary, non-limiting pump according to aspects of the invention; and

[0011] Figure 3 This is a graph illustrating exemplary, non-limiting oral care compositions according to aspects of the present invention and comparing the instability indices of oral care compositions.

[0012] It should be understood that the aspects are not limited to the arrangements and means shown in the attached figures. Detailed Implementation

[0013] For illustrative purposes, the principles of the invention are described by reference to several exemplary embodiments thereof. While certain embodiments of the invention have been specifically described herein, those skilled in the art will readily recognize that the same principles are equally applicable to and can be used in other compositions and methods. Before detailing the disclosed embodiments of the invention, it should be understood that the invention is not limited in its application to the details of any particular embodiment disclosed herein. The terminology used herein is for descriptive purposes and not for limitation.

[0014] As used herein and in the appended claims, unless the context otherwise requires, the singular forms “a,” “an,” and “the” include plural references. The singular form of any class of ingredients refers not only to a single chemical substance within that class but also to mixtures of such chemical substances. The terms “a” (or “an”), “a / a or more / a”, and “at least one / a” are used interchangeably herein. The terms “comprising,” “including,” and “having” are used interchangeably. The term “comprising” should be construed as “including, but not limited to.” The term “comprising” should be construed as “including but not limited to.”

[0015] As used throughout, a range is used as a shorthand to describe the individual values ​​within that range and each value. Any value within a range can be chosen as an endpoint of the range. Thus, the range 1 to 5 specifically includes 1, 2, 3, 4, and 5, as well as subranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.

[0016] The term “about” when referring to a number means any number within 10% of that number. For example, the phrase “about 2% by weight” refers to a number between 1.8% by weight and 2.2% by weight, and includes both 1.8% by weight and 2.2% by weight.

[0017] All references cited herein are incorporated herein by reference in their entirety. In the event of any conflict between the definitions in this disclosure and those in the cited references, the definitions in this disclosure shall prevail.

[0018] Unless otherwise stated, abbreviations and symbols used herein have their ordinary meanings. The abbreviation "wt%" indicates a percentage relative to the oral care composition by weight. The symbol "°" refers to a degree, such as a temperature reading or an angle reading. The symbols "h," "min," "mL," "nm," and "μm" refer to hours, minutes, milliliters, nanometers, and micrometers, respectively. The abbreviation "UV-VIS" when referring to a spectrometer or spectroscopy means ultraviolet-visible. The abbreviation "rpm" means revolutions per minute.

[0019] When referring to chemical structures and names, the symbols "C", "H", and "O" represent carbon, hydrogen, and oxygen, respectively. The symbols "–", "=", and "≡" represent single, double, and triple bonds, respectively.

[0020] As used in this article, "volatile" means a flash point below approximately 100°C. As used in this article, "non-volatile" means a flash point above approximately 100°C.

[0021] Any member of the species list used to exemplify or define a genus may be distinct from, overlap with, be a subset of, be equivalent to, be nearly identical to, or be identical to any other member of the species list. Furthermore, unless explicitly stated otherwise, for example when describing the Markush Formation, the list of species used to define or exemplify a genus is open-ended, and it is permissible for other species to exist that define or exemplify the genus that are exactly as good as or better than any other species listed.

[0022] The phrases “its mixture,” “its combination,” or “combination of two or more thereof” do not require that the mixture contain all of A, B, C, D, E, and F (although it may contain all of A, B, C, D, E, and F). Rather, it indicates a mixture that may contain any two or more of A, B, C, D, E, and F. In other words, it is equivalent to the phrase “a mixture of one or more elements selected from A, B, C, D, E, and F, and any two or more of A, B, C, D, E, and F.” Similarly, the term “its salt” also refers to “its various salts.” Therefore, when this disclosure refers to "elements selected from A, B, C, D, E, F, their salts, and mixtures thereof", it means that it may include one or more of A, B, C, D, and F, one or more of the salts of A, B, C, D, E, and F, or a mixture of any two of the salts of A, B, C, D, E, F, the salts of A, B, C, D, E, and F.

[0023] All components and elements affirmatively set forth in this disclosure may be negatively excluded from the claims. In other words, the oral care compositions of this disclosure may be free of or substantially free of all components and elements affirmatively recited throughout this disclosure. In some cases, the oral care compositions of this disclosure may be substantially free of non-incidental amounts of the ingredients or compounds described herein. Non-incidental amounts of an ingredient or compound are the amounts of that ingredient or compound added alone to the oral care composition. For example, an oral care composition may be substantially free of non-incidental amounts of an ingredient or compound, although such an ingredient or compound may be present as part of raw materials included in a blend of two or more compounds.

[0024] Some of the identified different categories of components may overlap. In cases where overlap is possible and the oral care composition contains two components (or more than two overlapping components), the overlapping compound does not represent more than one component. For example, some compounds may be characterized as both a polyol source and a sweetener. If a particular oral care composition details both a polyol and a sweetener, xylitol will be used only as either a polyol or a sweetener—not both.

[0025] For readability purposes, chemical functional groups are presented in their adjective form; for each adjective, it is assumed that the word "group" is used. For example, the adjective "alkyl" without a noun should be interpreted as "alkyl group".

[0026] This invention relates to oral care compositions suitable for dispensing with a pump, and oral care products comprising oral care compositions and having a pump for dispensing such oral care compositions. Formulating oral care compositions for use with pumps (e.g., shampoo pumps) is challenging due to pump nozzle drying or clogging, balancing the viscosity and pumpability of the oral care composition with maintaining oral care efficacy. The inventors have discovered that the problem of pump nozzle drying or clogging can be overcome using certain oral care compositions particularly suitable for pump dispensing. For example, the inventors have found that oral care compositions having specific polyol systems, thickening systems, and certain surfactants achieve an instability index preferably 0.04 or less, more preferably about 0.025 or less, more preferably about 0.02 or less as measured by Lumisizer testing, indicating reduced clogging and / or drying in the pump nozzle while achieving the desired pumping viscosity and pumpability.

[0027] According to one aspect of the invention, an oral care product is provided, the oral care product comprising: a container including a body defining a chamber and a pump extending into the chamber of the body; and an oral care composition disposed in the chamber, the oral care composition comprising: about 36% to about 72% by weight of a polyol system; a thickening system comprising about 0.4% to about 2.6% by weight of a silica thickener, natural gum and cellulose; one or more surfactants; and about 10% to about 36% by weight of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0028] According to another aspect, an oral care product is provided, the oral care product comprising: a container including a body defining a chamber and a pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: about 41 wt% to about 67 wt% of a polyol; a thickening system comprising about 0.4 wt% to about 2.6 wt% of a silica thickener, xanthan gum and carboxymethyl cellulose, wherein xanthan gum and carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2:1; and one or more surfactants, said one or more surfactants including betaine surfactants; and about 13 wt% to about 36 wt% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0029] According to another aspect, an oral care composition suitable for dispensing using a pump is provided, the oral care composition comprising about 36 wt% to about 72 wt% of a polyol system; a thickening system comprising about 0.4 wt% to about 2.6 wt% of a silica thickener, natural gum and cellulose; one or more surfactants; and about 10 wt% to about 36 wt% of water, wherein all weight percentages are based on the total weight of the oral care composition. Preferably, the oral care composition has an instability index, for example, measured according to a Lumisizer test, of 0.04 or less, more preferably about 0.025 or less, and even more preferably about 0.02 or less. In some other preferred embodiments, the pumping viscosity of the oral care composition is 2.5 to 4.5, preferably 2.8 to 4.2, or preferably 3 to 4.2. Additionally or alternatively, the pumping force of the oral care composition may preferably be 30 to 45 or about 35 to about 43. In some preferred embodiments, the yield stress of the oral care composition is 30 to 40, preferably about 35 to about 38.

[0030] According to yet another aspect, an oral care composition is provided for use in oral care products with pumps to reduce such pump blockage, the oral care composition comprising: about 36% to about 72% by weight of a polyol system; a thickening system comprising about 0.4% to about 2.6% by weight of a silica thickener, natural gum and cellulose; one or more surfactants; and about 10% to about 36% by weight of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0031] Oral care products typically include a container that comprises a body defining a chamber. In addition to the container, oral care products often include a pump. (See reference...) Figure 1 and Figure 2 The container 100 typically includes a body 110 and a pump 120. The body 110 defines a chamber suitable for containing an oral care composition. The pump 120 typically extends into the chamber defined by the body 110.

[0032] Reference Figure 2 Pump 120 may include a nozzle head 122, a plunger 124, a container cap 126, a sheath 128, a spring 130, a motor 132, a suction tube 134, and a PE 136. Pump 120 may have a suction tube 134 configured to extend into a chamber of body 110 when pump 120 is coupled to body 110. Pump 120 may be configured such that pressing nozzle head 122 in a direction toward sheath 128 actuates pump 120 to compress spring 130, thereby activating motor 132. Activating pump 120 may generate suction that draws oral care composition into suction tube 134 and through suction tube 134. Oral care composition may then be biased through nozzle head 122 to be dispensed from an opening in nozzle head 122. The operation of pump 120 will be readily understood by those skilled in the art. Further descriptions of pumps and components thereof that may be applied to some embodiments of the oral care products disclosed herein can be found in U.S. Patent Nos. 8,231,031, 2010 / 230,443, and 2021 / 229,123, all of which are incorporated herein by reference in their entirety for all purposes.

[0033] Preferably, the cross-sectional diameter D1 of the suction tube 134 can be from about 5 mm to about 15 mm. In some embodiments, the cross-sectional diameter D1 of the suction tube 134 is from about 5 mm to about 12 mm, from about 5 mm to about 10 mm, from about 5 mm to about 8 mm, from about 6 mm to about 8 mm, from about 7 mm to about 8 mm, or any range or subrange thereof. The nozzle length L1 of the pump 120 can be from about 7 mm to about 25 mm. In some embodiments, the nozzle length L1 of the nozzle head 122 is from about 7 mm to about 20 mm, from about 7 mm to about 16 mm, from about 7 mm to about 14 mm, from about 10 mm to about 14 mm, from about 12 mm to about 14 mm, or any range or subrange thereof.

[0034] Pump 120 may have a nozzle head 122 having a minimum cross-sectional area of ​​approximately 4 mm². 2 approximately 10mm 2 The channel. In some embodiments, the minimum cross-sectional area within the channel of the nozzle head 122 can be approximately 4 mm². 2 approximately 10mm 2 Approximately 4mm 2 Approximately 8mm 2 Approximately 4mm 2 Approximately 6mm 2 Approximately 6mm 2 approximately 10mm 2 Approximately 8mm 2 approximately 10mm 2 Approximately 5mm 2 Approximately 7mm 2 Or any range or subrange thereof. Without being limited by any particular theory, it is believed that problems with the oral care composition drying and / or clogging in nozzle head 122 may occur or cause problems at the minimum cross-sectional area. As discussed herein, embodiments of the oral care composition disclosed herein can advantageously avoid drying and / or clogging in nozzle head 120.

[0035] Oral care compositions may be in the form of dental cleaning agents, toothpaste, gels, etc. Depending on the specific combination of other ingredients and the form of the oral care composition, suitable components, such as those listed below, may be included in or excluded from the formulation for use with the oral care composition. Additionally or alternatively, in some embodiments, the oral care composition may have a single phase, comprising components and / or ingredients of the oral care composition. In other embodiments, the oral care composition may comprise two or more phases, such as two-phase, three-phase, four-phase, or five-phase.

[0036] Based on the total weight of the oral care composition, the oral care composition typically contains a polyol system in an amount of about 36% to about 72% by weight. For example, based on the total weight of the oral care composition, the total amount of the polyol system present in the oral care composition may be about 41% to about 72% by weight, about 44% to about 72% by weight, about 47% to about 72% by weight, about 50% to about 72% by weight, about 53% to about 72% by weight, about 57% to about 72% by weight; about 36% to about 67% by weight, about 41% to about 67% by weight, about 44% to about 67% by weight, about 47% to about 67% by weight, about 50% to about 67% by weight, about 53% to about 67% by weight, about 57% to about 67% by weight; about 36% to about 62% by weight, about 41% to about 62% by weight, about 44% to about 62% by weight, about 47% to about 62% by weight, about 50% to about 7 ...0% to about 72% by weight, about 41% to about 62% by weight, about 44% to about 62% by weight, about 47% to about 62% by weight, about 50% to about About 62 wt%, about 53 wt% to about 62 wt%, about 57 wt% to about 62 wt%; about 36 wt% to about 58 wt%, about 41 wt% to about 58 wt%, about 44 wt% to about 58 wt%, about 47 wt% to about 58 wt%, about 50 wt% to about 58 wt%, about 53 wt% to about 58 wt%; about 36 wt% to about 54 wt%, about 41 wt% to about 54 wt%, about 44 wt% to about 54 wt%, about 47 wt% to about 54 wt%, about 50 wt% to about 54 wt%; about 36 wt% to about 50 wt%, about 41 wt% to about 50 wt%, about 44 wt% to about 50 wt%, about 47 wt% to about 50 wt%; about 36 wt% to about 47 wt%, about 41 wt% to about 47 wt%, or any range or subrange thereof.

[0037] The polyol system can be selected from diols or compounds having multiple hydroxyl groups, such as glycerol. One or more polyols can be liquids at ambient temperature (25°C). Polyols can be wetting agents. In some cases, oral care compositions contain compounds selected from C2-C6. 32 One or more polyols. One or more polyols may have 2 to 32 carbon atoms, 3 to 16 carbon atoms, or 3 to 12 carbon atoms. For example, an oral care composition may comprise ethylene glycol, propylene glycol, butylene glycol, hexanediol, glycerin, diglycerol, diethylene glycol, dipropylene glycol, polyethylene glycol, or combinations thereof. In some embodiments, the polyol includes one or more diols, such as those selected from propylene glycol, ethylene glycol, butylene glycol, octyl glycol, polyethylene glycol, or combinations thereof.

[0038] The oral care composition preferably contains a reduced amount of sorbitol, is substantially free of sorbitol, or contains no sorbitol at all. In some preferred embodiments, the oral care composition has about 3% by weight or less, about 2% by weight or less, about 1% by weight or less, about 0.5% by weight or less, about 0.1% by weight or less, or about 0.01% by weight or less of sorbitol based on the total weight of the oral care composition. Ideally, the oral care composition may have 0% by weight of sorbitol based on the total weight of the oral care composition.

[0039] Preferably, the oral care composition comprises glycerin. For example, in some preferred embodiments, the oral care composition has glycerin in an amount of about 82% or more of the total weight of the polyols in the oral care composition. In some preferred embodiments, glycerin accounts for about 85% or more, about 88% or more, about 91% or more, about 93% or more, or about 96% or more of the total weight of the polyols in the oral care composition. In at least one embodiment, glycerin is the only polyol in the oral care composition. In another embodiment, the polyol system comprises glycerin and polyethylene glycol, such as polyethylene glycol 400, polyethylene glycol 600, or polyethylene glycol 800.

[0040] In addition to polyol systems, oral care compositions suitable for pump dispensing typically include a thickening system comprising a silica thickener, natural gum, and cellulose. The thickening system may be present in a total amount from about 1 wt% to about 5 wt% based on the total weight of the oral care composition. For example, the total amount of the thickening system may be from about 1 wt% to about 4 wt%, from about 1 wt% to about 3 wt%, from about 1 wt% to about 2.6 wt%, from about 1 wt% to about 2.2 wt%, from about 1 wt% to about 2 wt%; from about 1.5 wt% to about 5 wt%, from about 1.5 wt% to about 4 wt%, from about 1.5 wt% to about 3 wt%, from about 1.5 wt% to about 2.6 wt%; from about 2 wt% to about 5 wt%, from about 2 wt% to about 4 wt%, from about 2 wt% to about 3 wt%; from about 2.5 wt% to about 5 wt%, from about 2.5 wt% to about 4 wt%, or any range or subrange thereof.

[0041] Based on the total weight of the oral care composition, the silica thickener may be present in the oral care composition in an amount from about 0.4 wt% to about 2.6 wt%. In some preferred embodiments, based on the total weight of the oral care composition, the silica thickener is present in the following amounts: about 0.4 wt% to about 2.3 wt%, about 0.4 wt% to about 2 wt%, about 0.4 wt% to about 1.7 wt%, about 0.4 wt% to about 1.4 wt%; about 0.7 wt% to about 2.6 wt%, about 0.7 wt% to about 2.3 wt%, about 0.7 wt% to about 2 wt%, about 0.7 wt% to about 1.7 wt%, and about 0.7 wt% to about 1. 4 wt%; about 1 wt% to about 2.6 wt%, about 1 wt% to about 2.3 wt%, about 1 wt% to about 2 wt%, about 1 wt% to about 1.7 wt%, about 1 wt% to about 1.4 wt%; about 1.4 wt% to about 2.6 wt%, about 1.4 wt% to about 2.3 wt%, about 1.4 wt% to about 2 wt%; about 1.7 wt% to about 2.6 wt%, about 1.7 wt% to about 2.3 wt%; about 2 wt% to about 2.6 wt%, or any range or subrange thereof.

[0042] Thickened silica, sometimes called silica thickener, typically forms a polymeric structure or gel in aqueous media. Thickened silica generally differs physically and functionally from granular silica abrasives because silica thickeners are very fine and offer almost no abrasive action.

[0043] The thickening system may contain thickening silica with a particle size distribution (D95) less than or equal to 7 μm and a BET surface area greater than or equal to 150 m². 2 / g. In some cases, the BET surface area of ​​thickened silica is greater than or equal to 175m². 2 / g, greater than or equal to 200m 2 / g, or greater than or equal to 250m 2 / g. For example, the BET surface area of ​​thickened silica can be approximately 150m². 2 / g to approximately 350m 2 / g, approximately 170m 2 / g to approximately 350m 2 / g, approximately 190m 2 / g to approximately 350m 2 / g, approximately 210m 2 / g to approximately 350m 2 / g, approximately 230m 2 / g to approximately 350m 2 / g, approximately 250m 2 / g to approximately 350m 2 / g, approximately 270m 2 / g to approximately 350m 2 / g, approximately 290m 2 / g to approximately 350m 2 / g, approximately 310m 2 / g to approximately 350m 2 / g, approximately 330m 2 / g to approximately 350m 2 / g; approximately 150m 2 / g to approximately 300m 2 / g, approximately 170m 2 / g to approximately 300m 2 / g, approximately 190m 2 / g to approximately 300m 2 / g, approximately 210m 2 / g to approximately 300m 2 / g, approximately 230m 2 / g to approximately 300m 2 / g, approximately 250m 2 / g to approximately 300m 2 / g, approximately 270m 2 / g to approximately 300m 2 / g; approximately 150m 2 / g to approximately 275m 2 / g, approximately 170m 2 / g to approximately 275m 2 / g, approximately 190m 2 / g to approximately 275m 2 / g, approximately 210m 2 / g to approximately 275m 2 / g, approximately 230m 2 / g to approximately 275m 2 / g, approximately 250m 2 / g to approximately 275m 2 / g; approximately 150m 2 / g to approximately 250m 2 / g, approximately 170m 2 / g to approximately 250m 2 / g, approximately 190m 2 / g to approximately 250m 2 / g, approximately 210m 2 / g to approximately 250m 2 / g, approximately 230m 2 / g to approximately 250m 2 / g; approximately 150m 2 / g to approximately 225m 2 / g, approximately 170m 2 / g to approximately 225m 2 / g, approximately 190m2 / g to approximately 225m 2 / g, approximately 210m 2 / g to approximately 225m 2 / g, or any of its ranges or subranges.

[0044] Alternatively or concurrently, the oil absorption capacity of the thickened silica may be greater than or equal to about 200 mL / 100 g, about 240 mL / 100 g, about 250 mL / 100 g, or any range thereof. For example, the oil absorption capacity of the thickened silica may be about 200 mL / 100 g to about 250 mL / 100 g, about 210 mL / 100 g to about 250 mL / 100 g, about 220 mL / 100 g to about 250 mL / 100 g, about 230 mL / 100 g to about 250 mL / 100 g; about 200 mL / 100 g to about 240 mL / 100 g, about 210 mL / 100 g... g to about 240 mL / 100 g, about 220 mL / 100 g to about 240 mL / 100 g, about 230 mL / 100 g to about 240 mL / 100 g; about 200 mL / 100 g to about 230 mL / 100 g, about 210 mL / 100 g to about 230 mL / 100 g, about 220 mL / 100 g to about 230 mL / 100 g, or any range or subrange thereof.

[0045] In addition to silica thickeners, thickener systems typically also contain natural gums and cellulose. Based on the total weight of the oral care composition, the thickener system may contain natural gums in an amount from about 0.2 wt% to about 2 wt%. For example, based on the total weight of the oral care composition, one or more natural gums may be present in the oral care composition in the following total amounts: about 0.2 wt% to about 1.6 wt%, about 0.2 wt% to about 1.2 wt%, about 0.2 wt% to about 1 wt%, about 0.2 wt% to about 0.8 wt%, about 0.2 wt% to about 0.5 wt%; about 0.35 wt% to about 2 wt%, about 0.35 wt% to about 1.6 wt%, about 0.35 wt% to about 1.2 wt%, about 0.35 wt% to about 1 wt%, and about 0.35 wt% to about 0. 8 wt%, about 0.35 wt% to about 0.5 wt%; about 0.5 wt% to about 2 wt%, about 0.5 wt% to about 1.6 wt%, about 0.5 wt% to about 1.2 wt%, about 0.5 wt% to about 1 wt%, about 0.5 wt% to about 0.8 wt%; about 0.75 wt% to about 2 wt%, about 0.75 wt% to about 1.6 wt%, about 0.75 wt% to about 1.2 wt%, about 0.75 wt% to about 1 wt%; about 1 wt% to about 2 wt%, about 1 wt% to about 1.6 wt%, or any range or subrange thereof.

[0046] Examples of natural gums that may be included in or excluded from oral care compositions in certain embodiments include alginate, pectin, carrageenan, gum arabic, astragalus gum, ebony gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, seneca gum, sclerotinia gum, gellan gum, xanthan gum, or combinations thereof. For example, thickening systems may contain natural gums including gum arabic, astragalus gum, ebony gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, sclerotinia gum, gellan gum, xanthan gum, or combinations thereof. In some cases, oral care compositions contain natural gums selected from xanthan gum, carrageenan, pectin, alginate, pectin, and combinations thereof. In at least one preferred embodiment, the natural gum includes or is composed of xanthan gum.

[0047] Based on the total weight of the oral care composition, the amount of cellulose in the thickening system can be from about 0.05 wt% to about 1 wt%. In some cases, based on the total weight of the oral care composition, the total amount of cellulose in the oral care composition is from about 0.05 wt% to about 0.7 wt%, from about 0.05 wt% to about 0.5 wt%, from about 0.05 wt% to about 0.3 wt%, from about 0.05 wt% to about 0.1 wt%; from about 0.1 wt% to about 1 wt%, from about 0.1 wt% to about 0.7 wt%, from about 0.1 wt% to about 0.5 wt%, from about 0.1 wt% to about 0.3 wt%; from about 0.3 wt% to about 1 wt%, from about 0.3 wt% to about 0.7 wt%, from about 0.3 wt% to about 0.5 wt%; from about 0.5 wt% to about 1 wt%, from about 0.5 wt% to about 0.7 wt%, or any range or subrange thereof.

[0048] Examples of cellulose include cellulose ethers selected from: carboxymethyl cellulose (CMC), ethyl cellulose (EC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), methyl hydroxyethyl cellulose (MHEC), their salts, and mixtures thereof. In some embodiments, the cellulose is a modified cellulose selected from: microcrystalline cellulose (MCC) (e.g., in its anhydrous or hydrated form) and cellulose ethers (e.g., hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC)). In at least one preferred embodiment, the cellulose comprises carboxymethyl cellulose and / or its salts or consists of carboxymethyl cellulose and / or its salts.

[0049] Preferably, the thickening system is suitable for having xanthan gum and carboxymethyl cellulose present in a weight ratio of about 10:1 to about 2:1. In some preferred embodiments, the weight ratio of xanthan gum and carboxymethyl cellulose is about 8:1 to about 2:1, about 6:1 to about 2:1, about 5:1 to about 2:1, about 4:1 to about 2:1; about 10:1 to about 3:1, about 8:1 to about 3:1, about 6:1 to about 3:1, about 5:1 to about 3:1; about 10:1 to about 4:1, about 8:1 to about 4:1, about 6:1 to about 4:1; about 10:1 to about 5:1, about 8:1 to about 5:1, about 7:1 to about 5:1; about 10:1 to about 6:1, about 8:1 to about 6:1, or any range or subrange thereof.

[0050] Oral care compositions typically contain one or more surfactants. Based on the total weight of the oral care composition, the total amount of surfactants in the oral care composition can be from about 0.5% by weight to about 5% by weight. For example, based on the total weight of the oral care composition, the oral care composition may contain one or more surfactants in the following amounts: about 0.5% by weight to about 4% by weight, about 0.5% by weight to about 3% by weight, about 0.5% by weight to about 2% by weight, about 0.5% by weight to about 1.5% by weight; about 0.75% by weight to about 4% by weight, about 0.75% by weight to about 3% by weight, about 0.75% by weight to about 2% by weight, about 0.75% by weight to about 1.5% by weight; about 1% by weight to about 5% by weight, about 1% by weight to about 4% by weight, about 1% by weight... From about 3 wt%, from about 1 wt% to about 2 wt%; from about 1.5 wt% to about 5 wt%, from about 1.5 wt% to about 4 wt%, from about 1.5 wt% to about 3 wt%, from about 1.5 wt% to about 2 wt%; from about 2 wt% to about 5 wt%, from about 2 wt% to about 4 wt%, from about 2 wt% to about 3 wt%; from about 2.5 wt% to about 5 wt%, from about 2.5 wt% to about 4 wt%, from about 2.5 wt% to about 3.5 wt%; from about 3 wt% to about 5 wt%, from about 3 wt% to about 4 wt%, or any range or subrange thereof.

[0051] One or more surfactants may be selected from anionic surfactants, amphoteric surfactants, and / or combinations thereof. One or more surfactants may include anionic surfactants, such as those selected from water-soluble and water-miscible salts of alkyl sulfates, such as those having 8 to 20 carbon atoms in the alkyl group (e.g., sodium alkyl sulfate), and water-soluble or water-miscible salts of sulfonated monoglycerides of fatty acids having 8 to 20 carbon atoms. Examples of anionic surfactants that may be included in or excluded from oral care compositions in some cases include sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium lauryl sarcosinate, sodium cocoyl methyl taurate, sodium monoglyceride sulfate, sodium cetyl sulfate, potassium cocoyl glycinate, sodium lauryl phosphate, sodium lauryl lactylate, sodium lauryl sulfoacetate, sodium lauryl glutamate, sodium lauryl hydroxyethyl sulfonate, sodium lauryl ether carboxylate, sodium dodecylbenzene sulfonate, and combinations thereof. In some preferred embodiments, the anionic surfactant comprises or is composed of sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco-sulfate, ammonium coco-sulfate, and / or combinations thereof. In at least one embodiment, sodium lauryl sulfate and / or sodium lauryl ether sulfate are preferred surfactants. Other anionic surfactants are disclosed in U.S. Patent No. 3,959,458, which is incorporated herein by reference in its entirety for all purposes.

[0052] Based on the total weight of the oral care composition, the amount of anionic surfactant present in the oral care composition can be from about 0.1 wt% to about 5 wt%. In some cases, based on the total weight of the oral care composition, the oral care composition may contain anionic surfactant in the following amounts: about 0.1 wt% to about 4 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1.5 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.5 wt%; about 0.2 wt% to about 4 wt%, about 0.2 wt% to about 3 wt%, about 0.2 wt% to about 2 wt%, about 0.2 wt% to about 1.5 wt%, about 0.2 wt% to about 1 wt%, about 0.2 wt% to about 0.5 wt%; about 0.5 wt% to about 4 wt%, about 0.5 wt% to about 3 wt%. The amounts are expressed as follows: %; about 0.5 wt% to about 2 wt%; about 0.5 wt% to about 1.5 wt%; about 0.75 wt% to about 4 wt%; about 0.75 wt% to about 3 wt%; about 0.75 wt% to about 2 wt%; about 0.75 wt% to about 1.5 wt%; about 1 wt% to about 5 wt%; about 1 wt% to about 4 wt%; about 1 wt% to about 3 wt%; about 1 wt% to about 2 wt%; about 1.5 wt% to about 5 wt%; about 1.5 wt% to about 4 wt%; about 1.5 wt% to about 3 wt%; about 2 wt% to about 5 wt%; about 2 wt% to about 4 wt%; about 2 wt% to about 3 wt%, or any range or subrange thereof.

[0053] Amphoteric surfactants are preferably selected from betaine surfactants. Examples of betaine surfactants include cocamidopropyl betaine, lauryl dimethyl betaine (sold under the trade name Macat LB), cetyl dimethyl betaine, and cocoamphodiacetate. Amphoteric surfactants may contain substituents having 8 to 18 carbon atoms and substituents having one or more carboxyl, sulfonate, sulfate, phosphate, or phosphonate groups. For example, amphoteric surfactants may have alkyl groups having 8 to 20 carbon atoms, 8 to 16 carbon atoms, 10 to 16 carbon atoms, or 10 to 13 carbon atoms. Amphoteric surfactants may include, but are not limited to, derivatives of linear or branched aliphatic secondary and tertiary amines. In some cases, one of the aliphatic substituents of the amphoteric surfactant contains about 8 to about 18 carbon atoms and one of the aliphatic substituents contains anionic water-solubilizing groups, such as carboxyl, sulfonate, sulfate, phosphate, or phosphonate groups. The amphoteric surfactants disclosed herein may be present in the oral care composition in the form of salts. Other examples of amphoteric surfactants that may be included in the oral care composition or, in some preferred embodiments, may be excluded from the oral care composition include alkyl sulfonate, alkyl amphoacetate, and alkyl amphopropionate. In at least one embodiment, the amphoteric surfactant comprises or is composed of cocamidopropyl betaine.

[0054] Based on the total weight of the oral care composition, the amount of amphoteric surfactant present in the oral care composition can be from about 0.1 wt% to about 5 wt%. In some cases, based on the total weight of the oral care composition, the oral care composition contains anionic surfactants in the following amounts: about 0.1 wt% to about 4 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1.5 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.5 wt%; about 0.3 wt% to about 4 wt%, about 0.3 wt% to about 3 wt%, about 0.3 wt% to about 2 wt%, about 0.3 wt% to about 1.5 wt%, about 0.3 wt% to about 1 wt%, about 0.2 wt% to about 0.5 wt%; about 0.5 wt% to about 4 wt%, about 0.5 wt% to about 3 wt%, about 0.5 wt% to about 2 wt%, about 0.5 wt%. % to about 1.5 wt%; about 0.75 wt% to about 4 wt%, about 0.75 wt% to about 3 wt%, about 0.75 wt% to about 2 wt%, about 0.75 wt% to about 1.5 wt%; about 1 wt% to about 5 wt%, about 1 wt% to about 4 wt%, about 1 wt% to about 3 wt%, about 1 wt% to about 2 wt%; about 1.5 wt% to about 5 wt%, about 1.5 wt% to about 4 wt%, about 1.5 wt% to about 3 wt%, about 1.5 wt% to about 2 wt%; about 2 wt% to about 5 wt%, about 2 wt% to about 4 wt%, about 2 wt% to about 3 wt%; about 2.5 wt% to about 5 wt%, about 2.5 wt% to about 4 wt%, about 2.5 wt% to about 3.5 wt%, or any range or subrange thereof.

[0055] Oral care compositions typically contain water. The total amount of water in the oral care composition can be from about 10% by weight to about 36% by weight, based on the total weight of the oral care composition. In some preferred embodiments, the total amount of water present in the oral care composition, based on the total weight of the oral care composition, is about 10% by weight to about 36% by weight, about 10% by weight to about 31% by weight, about 10% by weight to about 26% by weight, about 10% by weight to about 23% by weight, about 10% by weight to about 21% by weight, about 10% by weight to about 19% by weight, about 10% by weight to about 17% by weight, about 10% by weight to about 15% by weight; about 13% by weight to about 36% by weight, about 13% by weight to about 31% by weight, about 13% by weight to about 26% by weight, about 13% by weight to about 23% by weight, about 13% by weight to about 21% by weight, about 13% by weight to about 19% by weight. %; about 16 wt% to about 36 wt%, about 16 wt% to about 31 wt%, about 16 wt% to about 26 wt%, about 16 wt% to about 23 wt%, about 16 wt% to about 21 wt%; about 19 wt% to about 36 wt%, about 19 wt% to about 31 wt%, about 19 wt% to about 26 wt%, about 19 wt% to about 23 wt%, about 19 wt% to about 21 wt%; about 21 wt% to about 36 wt%, about 21 wt% to about 31 wt%, about 21 wt% to about 26 wt%, about 21 wt% to about 23 wt%; about 25 wt% to about 36 wt%, about 25 wt% to about 31 wt%, or any range or subrange thereof.

[0056] Based on the total weight of the oral care composition, the oral care composition may, for example, contain one or more abrasives in an amount from about 7% to about 30% by weight. In some cases, based on the total weight of the oral care composition, the amount of abrasive in the oral care composition is about 7% to about 27% by weight, about 7% to about 23% by weight, about 7% to about 19% by weight, about 7% to about 17% by weight, about 7% to about 15% by weight, about 7% to about 13% by weight; about 10% to about 30% by weight, about 10% to about 27% by weight, about 10% to about 23% by weight, about 10% to about 19% by weight, about 10% to about 17% by weight, about 10% to about 15% by weight; about 13% to about 30% by weight, about 13% to about 27% by weight, about 13% by weight... % to about 23 wt%, about 13 wt% to about 19 wt%, about 13 wt% to about 17 wt%, about 13 wt% to about 15 wt%; about 15 wt% to about 30 wt%, about 15 wt% to about 27 wt%, about 15 wt% to about 23 wt%, about 15 wt% to about 19 wt%; about 17 wt% to about 30 wt%, about 17 wt% to about 27 wt%, about 17 wt% to about 23 wt%; about 19 wt% to about 30 wt%, about 19 wt% to about 27 wt%, about 19 wt% to about 23 wt%; about 23 wt% to about 30 wt%, about 23 wt% to about 27 wt%, or any range or subrange thereof.

[0057] Abrasives may include or be selected from the following: silica abrasives, silicates, silicon, alumina (including calcined alumina), aluminosilicates, bentonite, zeolite, kaolin, mica, silica or diatomaceous earth, pumice, calcium compounds, calcium carbonate, cuttlebone, composite resins (e.g., melamine resin, phenolic resin, and urea-formaldehyde resin), polycarbonate, silicon carbide, boron carbide, microcrystalline wax, microcrystalline cellulose (e.g., a combination of colloidal microcrystalline cellulose and carboxymethyl cellulose), dicalcium phosphate, calcium pyrophosphate, dicalcium orthophosphate dihydrate, tricalcium phosphate, polymetaphosphate, calcium carbonate, calcium bicarbonate, and combinations thereof. In some embodiments, the oral care composition comprises one or more abrasives selected from the following: dicalcium phosphate, calcium pyrophosphate, dicalcium orthophosphate dihydrate, tricalcium phosphate, polymetaphosphate, calcium carbonate, calcium bicarbonate, or combinations thereof. In other embodiments, the oral care composition comprises an abrasive selected from calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, resinous abrasive materials (e.g., granular condensation products of urea and formaldehyde), and combinations thereof. In at least one preferred embodiment, the abrasive comprises, or is preferably composed of, silica abrasive. For example, the abrasive is selected from high-cleanliness silica.

[0058] Based on the total weight of the oral care composition, the oral care composition may contain potassium caustic soda (KOH) in an amount from about 0.25 wt% to about 5 wt%. For example, based on the total weight of the oral care composition, the amount of potassium caustic soda (KOH) in the oral care composition may preferably be from about 0.25 wt% to about 4 wt%, from about 0.25 wt% to about 3 wt%, from about 0.25 wt% to about 2 wt%, from about 0.25 wt% to about 1.5 wt%, from about 0.25 wt% to about 1 wt%; from about 0.5 wt% to about 4 wt%, from about 0.5 wt% to about 3 wt%, from about 0.5 wt% to about 2 wt%, from about 0.5 wt% to about 1.5 wt%; from about 0.75 wt% to about 4 wt%, from about 0.75 wt% to about 3 wt%, from about 0.75 wt% to about 2 wt%, from about 0.75 wt% to about 1.5 wt%; from about 1 wt% to about 5 wt%. The amounts are expressed as follows: 1 wt% to 4 wt%, 1 wt% to 3 wt%, 1 wt% to 2 wt%; 1.25 wt% to 5 wt%, 1.25 wt% to 4 wt%, 1.25 wt% to 3 wt%, 1.25 wt% to 2 wt%; 1.5 wt% to 5 wt%, 1.5 wt% to 4 wt%, 1.5 wt% to 3 wt%, 1.5 wt% to 2 wt%; 2 wt% to 5 wt%, 2 wt% to 4 wt%, 2 wt% to 3 wt%; 2.5 wt% to 5 wt%, 2.5 wt% to 4 wt%, 2.5 wt% to 3.5 wt%, or any range or subrange thereof.

[0059] The oral care composition may contain an anti-tartar agent. Based on the total weight of the oral care composition, the amount of the anti-tartar agent present in the oral care composition may be from about 0.5% by weight to about 10% by weight. In some cases, based on the total weight of the oral care composition, the anti-tartar agent is present in the oral care composition in the following amounts: about 0.5% by weight to about 8% by weight, about 0.5% by weight to about 6% by weight, about 0.5% by weight to about 5% by weight, about 0.5% by weight to about 4% by weight, about 0.5% by weight to about 3% by weight, about 0.5% by weight to about 2% by weight; about 1% by weight to about 10% by weight, about 1% by weight to about 8% by weight, about 1% by weight to about 6% by weight, about 1% by weight to about 5% by weight, about 1% by weight to about 4% by weight, about 1% by weight to about 3% by weight, about 1% by weight to about 2% by weight; about 2% by weight % to about 10 wt%, about 2 wt% to about 8 wt%, about 2 wt% to about 6 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 4 wt%, about 2 wt% to about 3 wt%; about 3 wt% to about 10 wt%, about 3 wt% to about 8 wt%, about 3 wt% to about 6 wt%, about 3 wt% to about 5 wt%, about 3 wt% to about 4 wt%; about 5 wt% to about 10 wt%, about 5 wt% to about 8 wt%, about 5 wt% to about 6 wt%; about 7 wt% to about 10 wt%, about 7 wt% to about 8 wt%, about 8 wt% to about 10 wt%, or any range or subrange thereof.

[0060] Anti-tartar agents can be selected from phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate, zinc citrate trihydrate, peptides, polyolefin sulfonates, polyolefin phosphates, bisphosphonates, and combinations thereof. Examples of anti-tartar agents include tetrasodium pyrophosphate, ammonium tripolyphosphate, hexametaphosphate, polycarboxylate polymers, polyethylene methyl ether / maleic anhydride (PVME / MA) copolymers, or combinations thereof. In some embodiments, the oral care composition comprises one or more alkali metal polyphosphates, such as tetrasodium pyrophosphate.

[0061] The oral care composition may optionally contain a fluoride ion source. The fluoride ion source may be present in an effective amount. In some cases, the fluoride ion source is present in the oral care composition in an amount of about 0.01% by weight to about 5% by weight, based on the total weight of the oral care composition. For example, based on the total weight of the oral care composition, the fluoride ion source is present in the following amounts: about 0.01 wt% to about 5 wt%, about 0.01 wt% to about 4 wt%, about 0.01 wt% to about 3 wt%, about 0.01 wt% to about 2 wt%, about 0.01 wt% to about 1 wt%; about 0.05 wt% to about 5 wt%, about 0.05 wt% to about 4 wt%, about 0.05 wt% to about 3 wt%, about 0.05 wt% to about 2 wt%, about 0.05 wt% to about 1 wt%; about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 4 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%; about 0.3 wt% to about 5 wt%, about 0.3 wt% to about 4 wt%, about 0.3 wt% to about 3 wt%, about 0.3 wt% to about 2 wt%; about 0.6 wt% to about 5 wt%, about 0.6 wt% to about 4 wt%, about 0.6 wt% to about 3 wt%, about 0.6 wt% to about 2 wt%; about 0.9 wt% to about 5 wt%, about 0.9 wt% to about 4 wt%, about 0.9 wt% to about 3 wt%, about 0.9 wt% to about 2 wt%; about 1.2 wt% to about 5 wt%, about 1.2 wt% to about 4 wt%, about 1.2 wt% to about 3 wt%, about 1.2 wt% to about 2 wt%; about 1.5 wt% to about 5 wt%, about 1.5 wt% to about 4 wt%, about 1.5 wt% to about 3 wt%; about 2 wt% to about 5 wt%, about 2 wt% to about 4 wt%, about 2 wt% to about 3 wt%; about 3 wt% to about 5 wt%, about 4 wt% to about 5 wt%, or any range or subrange thereof.

[0062] Fluoride ion sources can be selected from soluble fluoride salts. For example, fluoride ion sources may include sodium fluoride, potassium fluoride, calcium fluoride, zinc fluoride, zinc ammonium fluoride, lithium fluoride, ammonium fluoride, stannous fluoride, stannous fluorozirconate, sodium monofluorophosphate, potassium monofluorophosphate, laurylamine hydrofluoride, diethylaminoethyloctoylamide hydrofluoride, decyl dimethyl ammonium fluoride, and cetylpyridine fluoride. dilaurylmorpholine fluoride Stannous sarcosine fluoride, potassium glycine fluoride, glycine hydrofluoride, fluorinated amines, or combinations thereof. In some embodiments, the fluoride ion source includes sodium fluoride, sodium monofluorophosphate, or combinations thereof. Further examples of fluoride ion sources are disclosed in U.S. Patent Nos. 3,535,421, 4,885,155, and 3,678,154, the disclosures of which are incorporated herein by reference in their entirety.

[0063] In some embodiments, the oral care compositions of this disclosure may contain a fluoride ion source or a reagent that provides fluoride in an amount sufficient to deliver a total of 25 ppm to 25,000 ppm (mass fraction), typically at least 500 ppm, such as about 500 ppm to about 2,000 ppm, about 800 ppm to about 1,800 ppm, about 1,000 ppm to about 1,600 ppm, about 1,200 ppm to about 1,550 ppm, or about 1,450 ppm.

[0064] The oral care compositions of this disclosure may include flavoring agents. Flavoring agents are typically incorporated into the oral care composition at a concentration of about 0.01 wt% to about 3 wt% based on the weight of the oral care composition. For example, based on the total weight of the oral care composition, the amount of flavoring agent present in the oral care composition may be about 0.01 wt% to about 2 wt%, about 0.01 wt% to about 1 wt%, about 0.01 wt% to about 0.5 wt%, about 0.01 wt% to about 0.1 wt%; about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.5 wt%; about 0.5 wt% to about 3 wt%, about 0.5 wt% to about 2 wt%, about 0.5 wt% to about 1 wt%; about 1 wt% to about 3 wt%, about 1 wt% to about 2 wt%; about 2 wt% to about 3 wt%, including any range or subrange thereof.

[0065] Suitable flavoring agents include, but are not limited to, essential oils and a variety of flavoring aldehydes, esters, alcohols, and similar substances. Examples of essential oils include spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange oils. Chemicals such as menthol, carvone, and anethole are also useful. Other flavoring agents may include, but are not limited to, menthol, artificial vanilla, cinnamon derivatives and various fruit flavorings, spearmint oil, peppermint oil, cinnamon oil, wintergreen oil (methyl salicylate), clove oil, laurel oil, anise oil, eucalyptus oil, thyme oil, cedarwood leaf oil, nutmeg oil, sage oil, bitter almond oil, cinnamon oil, and combinations of two or more of these.

[0066] Oral care compositions may contain one or more colorants. Exemplary colorants may include natural or uncertified pigments of natural origin, or pigments certified for color effects. In some embodiments, colorants may include dyes, certified aluminum lakes, or pigments derived from natural sources. Colorants may be water-based, oil-based, or dry. Colorants may be primary pigments, pigment blends, or discrete pigment mixtures, such as confetti. Based on the total weight of the oral care composition, the concentration of colorants in the oral care composition may range from trace amounts to about 0.6% by weight, about 0.1% by weight to about 0.5% by weight, about 0.2% by weight to about 0.4% by weight, or about 0.15% by weight to about 0.35% by weight.

[0067] Oral care compositions may contain one or more pH adjusters to raise or lower the overall pH of the oral care composition. For example, one or more acids may be included to lower the pH of the oral care composition. Examples of suitable acids for lowering the pH of an oral care composition include, but are not limited to, citric acid, acetic acid, etc. Oral care compositions may contain one or more bases (e.g., sodium hydroxide, potassium hydroxide, etc.) to raise the pH of the oral care composition. Other or alternative acids and bases suitable for adjusting the pH of oral care compositions will be readily apparent to those skilled in the art.

[0068] The amount of pH adjuster in an oral care composition can be based on the desired pH of the final oral care composition and / or product. For example, the total amount of pH adjuster can range from about 0.05% by weight to about 20% by weight, based on the total weight of the oral care composition. In some cases, the total amount of pH adjuster is about 0.05% by weight to about 15% by weight, about 0.1% by weight to about 10% by weight, or about 0.12% by weight to about 5% by weight, including ranges and subranges therein, based on the total weight of the oral care composition.

[0069] The pH of the oral care composition may be 4.5 to about 10, 4.5 to about 9, 4.5 to about 8, 4.5 to about 7, 4.5 to about 6; about 5 to about 10, about 5 to about 9, about 5 to about 8, about 5 to about 7, about 5 to about 6; about 6 to about 10, about 6 to about 9, about 6 to about 8, or about 6 to about 7; about 7 to about 10, about 7 to about 9, or about 7 to about 8, including any range and subrange therein.

[0070] According to yet another aspect, an oral care composition is provided for use in a pump-equipped oral care product to reduce such pump clogging, the oral care composition comprising: about 36 wt% to about 72 wt% of a polyol system; a thickening system comprising about 0.4 wt% to about 2.6 wt% of a silica thickener, natural gum, and cellulose; one or more surfactants; and about 10 wt% to about 36 wt% of water, wherein all weight percentages are based on the total weight of the oral care composition. Preferably, the instability index of the oral care composition for use in a pump-equipped oral care product to reduce such pump clogging, as measured by the Lumisizer test, is 0.04 or less, more preferably about 0.025 or less, and even more preferably about 0.02 or less. In some other preferred embodiments, the pumping viscosity of the oral care composition for use in a pump-equipped oral care product to reduce such pump clogging during dispensing of the oral care composition with such a pump is 2.5 to 4.5, preferably 2.8 to 4.2, or preferably 3 to 4.2. Alternatively or concurrently, the pumping force of the oral care composition used in the pump-equipped oral care product to reduce such pump clogging is 30 to 45, or about 35 to about 43, for dispensing the oral care composition with such a pump. In some preferred embodiments, the yield stress of the oral care composition used in the pump-equipped oral care product to reduce such pump clogging during dispensing of the oral care composition with such a pump is 30 to 40, preferably about 35 to about 38.

[0071] Example

[0072] Example 1

[0073] According to some aspects of the invention, four non-limiting oral care compositions of the embodiments were prepared in the form of dental cleaning agents. Four comparative compositions (comparative compositions 1 to 4) were also prepared in the form of dental cleaning agents. Formulations for the embodiment compositions A to D and comparative compositions 1 to 4 are provided in Table 1.

[0074] Table 1

[0075]

[0076] Example 2

[0077] Examples A to D and comparative compositions 1 to 4 were placed in an oral care container, the container comprising a body with a defined chamber and a pump. The oral care container and the various dental cleaning agents therein were placed in a controlled environment at 49°C for 1 day to allow the dental cleaning agents to age. The oral care container was evaluated for potential blockages within the pump.

[0078] The stability of Example Compositions A through D and Comparative Compositions 1 through 4 was then evaluated. Specifically, a Lumisizer test was performed to predict the stability of the formulation. The Lumisizer analytical centrifugation test (also referred to herein as the “Lumisizer test”) is a test method designed to predict gravity-driven separation of toothpaste formulations over their expected shelf life. Typically, an instability index of 0.05 or less indicates a shelf life of at least 2 years. A lower instability index indicates better product stability performance and a significant reduction in pump clogging. The instability indices of Example Compositions A through D and Comparative Compositions 1 through 4 were... Figure 3 As shown in the image.

[0079] Example 3

[0080] The rheological properties, including pumping viscosity, pumping force, and yield stress, of Examples B and D, and Comparative Compositions 1 and 2 were evaluated. Pumping viscosity represents gel distribution properties. Yield stress represents the amount of stress required to flow the oral care composition through a pump. A summary of the pumping viscosity, pumping force, and yield stress of Examples B and D, and Comparative Compositions 1 and 2 is provided in Table 2.

[0081] Table 2

[0082] Comp1 Comp2 Ex.B Ex.D Pumping viscosity (Pa·s) 6 2.1 4.2 3 Pumping force (N) 40.3 26.1 42.4 36.6 Yield stress 49.6 26.4 37.9 35.8

Claims

1. An oral care product, comprising: A container comprising a body defining a chamber and a pump extending into the chamber of the body; An oral care composition disposed in the chamber, the oral care composition comprising: A polyol system of approximately 36% to approximately 72% by weight; Thickening system, the thickening system comprising: From about 0.4% to about 2.6% by weight of silica thickener, Natural rubber; and Cellulose; One or more surfactants; and Water, approximately 10% by weight to approximately 36% by weight, wherein all weight percentages are based on the total weight of the oral care composition.

2. The oral care product of claim 1, wherein the instability index of the oral care composition, as measured by the Lumisizer test, is 0.04 or less.

3. The oral care product according to claim 1 or claim 2, wherein the silica thickener is present in an amount of about 0.7% by weight to about 2.2% by weight of the thickening silica.

4. The oral care product according to any of the preceding claims, wherein the silica thickener is present in an amount of about 1% to about 2% by weight of the thickening silica.

5. The oral care product according to any of the preceding claims, wherein the natural gum is selected from gum arabic, astragalus gum, ebony gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, sclerotium gum, gellan gum, xanthan gum, and combinations of two or more thereof.

6. The oral care product according to any of the preceding claims, wherein the natural gum comprises xanthan gum.

7. The oral care product according to any of the preceding claims, wherein the cellulose is selected from carboxymethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, and combinations thereof or more.

8. The oral care product according to any of the preceding claims, wherein the cellulose comprises carboxymethyl cellulose.

9. The oral care product according to any of the preceding claims, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2:

1.

10. The oral care product according to any of the preceding claims, wherein the one or more surfactants are selected from anionic surfactants, amphoteric surfactants, and combinations thereof.

11. The oral care product of claim 10, wherein the anionic surfactant comprises sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium cocoyl sulfate, ammonium cocoyl sulfate, or a combination thereof.

12. The oral care product according to claim 10 or claim 11, wherein the amphoteric surfactant comprises a betaine surfactant.

13. The oral care product according to any of the preceding claims, wherein the one or more surfactants are selected from cocamidopropyl betaine, lauryl dimethyl betaine, cetyl dimethyl betaine, coacromegadiacetate, sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium cocoyl sulfate, ammonium cocoyl sulfate, and combinations of two or more thereof.

14. The oral care product according to any of the preceding claims, wherein the one or more surfactants are selected from cocamidopropyl betaine, sodium lauryl sulfate, sodium lauryl ether sulfate, and combinations thereof.

15. The oral care product according to any of the preceding claims, wherein the polyol system comprises glycerin.

16. The oral care product according to any of the preceding claims, wherein glycerin accounts for about 82% by weight or more of the polyol system based on the total weight of the polyols in the oral care composition.

17. The oral care product according to any of the preceding claims, wherein the oral care composition is substantially free of sorbitol or contains no sorbitol.

18. The oral care product according to any of the preceding claims, wherein the polyol system comprises glycerin, polyethylene glycol, and combinations thereof.

19. The oral care product according to any of the preceding claims, wherein the thickening system is present in a total amount of about 1% to about 5% by weight, based on the total weight of the polyols in the oral care composition.

20. The oral care product according to any of the preceding claims, wherein the pump includes a suction tube with a cross-sectional diameter of about 5 mm to about 15 mm.

21. The oral care product according to any of the preceding claims, wherein the pump includes a nozzle with a nozzle length of about 7 mm to about 25 mm.

22. The oral care product according to any of the preceding claims, wherein the minimum cross-sectional area of ​​the nozzle is approximately 4 mm². 2 approximately 10mm 2 .

23. An oral care product, comprising: A container comprising a body defining a chamber and a pump extending into the chamber of the body; An oral care composition disposed in the chamber, the oral care composition comprising: From about 41% by weight to about 67% by weight of polyols; A thickening system, wherein the thickening system comprises the following: From about 0.4% to about 2.6% by weight of silica thickener, Xanthan gum, and Carboxymethyl cellulose, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2:1; One or more surfactants, said one or more surfactants including betaine surfactants; and Water, approximately 13% to approximately 23% by weight, wherein all weight percentages are based on the total weight of the oral care composition.

24. An oral care composition suitable for dispensing using a pump, the oral care composition comprising: A polyol system of approximately 36% to approximately 72% by weight; Thickening system, the thickening system comprising: From about 0.4% to about 2.6% by weight of silica thickener, Natural rubber; and Cellulose; One or more surfactants; and Water, approximately 10% by weight to approximately 36% by weight, wherein all weight percentages are based on the total weight of the oral care composition.

25. An oral care composition for use in an oral care product having a pump to reduce clogging within such a pump, said oral care composition comprising: A polyol system of approximately 36% to approximately 72% by weight; Thickening system, the thickening system comprising: From about 0.4% to about 2.6% by weight of silica thickener, Natural rubber; and Cellulose; One or more surfactants; and Water, approximately 10% by weight to approximately 36% by weight, wherein all weight percentages are based on the total weight of the oral care composition.

26. The oral care composition of claim 24 or claim 25, wherein the instability index of the oral care composition, as measured by the Lumisizer test, is 0.04 or less.

27. The oral care composition according to any one of claims 24 to 26, wherein the silica thickener is present in an amount of about 0.7% by weight to about 2.2% by weight of the thickening silica.

28. The oral care composition according to any one of claims 24 to 27, wherein the silica thickener is present in an amount of about 1% to about 2% by weight of the thickening silica.

29. The oral care composition according to any one of claims 24 to 28, wherein the natural gum is selected from gum arabic, astragalus gum, ebony gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, sclerotium gum, gellan gum, xanthan gum, and combinations of two or more thereof.

30. The oral care composition according to any one of claims 24 to 29, wherein the natural gum comprises xanthan gum.

31. The oral care composition according to any one of claims 24 to 30, wherein the cellulose is selected from carboxymethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose (MHEC), and combinations thereof or more.

32. The oral care composition according to any one of claims 24 to 31, wherein the cellulose comprises carboxymethyl cellulose.

33. The oral care composition according to any one of claims 24 to 32, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2:

1.

34. The oral care composition according to any one of claims 24 to 33, wherein the one or more surfactants are selected from anionic surfactants, amphoteric surfactants, and combinations thereof.

35. The oral care composition of claim 34, wherein the anionic surfactant comprises sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium cocoyl sulfate, ammonium cocoyl sulfate, or combinations thereof.

36. The oral care composition of claim 34 or claim 35, wherein the amphoteric surfactant comprises a betaine surfactant.

37. The oral care composition according to any one of claims 24 to 36, wherein the one or more surfactants are selected from cocamidopropyl betaine, lauryl dimethyl betaine, cetyl dimethyl betaine, coacromegadiacetate, sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium cocoyl sulfate, ammonium cocoyl sulfate, and combinations of two or more thereof.

38. The oral care composition according to any one of claims 24 to 37, wherein the one or more surfactants are selected from cocamidopropyl betaine, sodium lauryl sulfate, sodium lauryl ether sulfate, and combinations thereof.

39. The oral care composition according to any one of claims 24 to 38, wherein the polyol system comprises glycerin.

40. The oral care composition according to any one of claims 24 to 39, wherein glycerin accounts for about 82% by weight or more of the polyol system based on the total weight of the polyols in the oral care composition.

41. The oral care composition according to any one of claims 24 to 40, wherein the oral care composition is substantially free of sorbitol or contains no sorbitol.

42. The oral care composition according to any one of claims 24 to 41, wherein the polyol system comprises glycerin, polyethylene glycol, and combinations thereof.

43. The oral care composition according to any one of claims 24 to 42, wherein the thickening system is present in a total amount of about 1% to about 5% by weight, based on the total weight of the polyols in the oral care composition.

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