Lipid-polymer composition comprising retinol and methods of making and using the same

Abstract

The present application relates to the cosmetic technical field, specifically, it relates to a kind of lipid-polymer composition comprising retinol and its preparation method and application.The component includes retinol 1-15%, solvent oil 10-20%, antioxidant 0.1-1%, emulsifier 1-4.5%, lipid 1-2%, polyol 10-20%, polymer 0.05-0.5% by mass percentage, and the balance is water.The present application can significantly improve the stability of retinol and system by the compounding of specific retinol, solvent oil, antioxidant, emulsifier, lipid, polyol and polymer, solve the problem of easy oxidative degradation of retinol;By limiting the emulsifier to be polyglycerol emulsifier, combined with lipid and polymer hybridization wrapping, the skin irritation of retinol can be effectively reduced, and the defects of strong irritation of retinol and limited application population can be effectively solved.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a lipid-polymer composition containing retinol, its preparation method, and its application. Background Technology

[0002] Retinol, a classic and highly effective anti-aging active ingredient in cosmetics, can regulate skin cell gene expression, promote collagen synthesis, and inhibit collagen degradation, showing definite effects in improving photoaging, reducing fine lines, and accelerating epidermal renewal. However, retinol molecules contain multiple unsaturated double bonds, making them highly sensitive to light, heat, and oxygen. In water-based formulations, they are easily oxidized, degraded, and inactivated. Furthermore, high concentrations can easily trigger skin irritation reactions such as erythema, stinging, and peeling. These stability and tolerability issues severely limit its application. To address these problems, the industry has successively adopted technologies such as antioxidant protection, oil-phase matrix isolation, microencapsulation, liposome encapsulation, and cyclodextrin inclusion complexation. However, all of these have significant limitations: traditional antioxidant and oil-phase isolation can only slightly delay degradation; microcapsule particle size is too large, affecting skin feel and making release behavior difficult to control; liposomes have poor thermodynamic stability, easily merging and leaking, leading to decreased encapsulation efficiency; while cyclodextrin inclusion complexation improves water solubility, it significantly reduces retinol permeability and bioactivity.

[0003] Chinese invention patent application CN114939079A discloses the preparation and application of a retinol encapsulation system, which constructs an encapsulation system using oils, antioxidants, and conventional emulsifiers, thus improving retinol stability to some extent. However, this technology does not employ a lipid-polymer hybrid carrier structure, relying solely on simple encapsulation, and cannot form a delivery system that balances structural strength and skin affinity; it also fails to effectively address the retinol irritation issue, and cannot simultaneously meet the cosmetic application requirements of high stability, low irritation, and high permeability. Lipid-polymer hybrid carriers can combine the biocompatibility of lipids with the structural stability of polymers, representing an optimized direction for retinol delivery. However, existing technologies lack precise formulations, processes, and performance control schemes suitable for cosmetics, necessitating the development of a retinol delivery system with excellent stability, high safety, and strong permeability. Summary of the Invention

[0004] The first aspect of the present invention provides a lipid-polymer composition loaded with retinol, comprising, by weight percentage, 1-15% retinol, 10-20% solvent oil, 0.1-1% antioxidant, 1-4.5% emulsifier, 1-2% lipid, 10-20% polyol, 0.05-0.5% polymer, and the balance being water.

[0005] Currently, retinol systems rely on single antioxidant protection, ordinary emulsifier encapsulation, or simple oil-phase isolation, lacking a multi-component synergistic structural stabilization design. Their ability to block light, heat, and oxygen is weak, leading to problems such as carrier leakage, particle agglomeration, and rapid degradation of active ingredients, failing to fundamentally address the core defect of retinol's easy oxidation and inactivation. This invention constructs a lipid-polymer hybrid synergistic stabilization system through a precise blending of retinol, solvent oil, antioxidant, polyglycerol emulsifier, compounded solid lipids, polyol, and polymer in specific proportions. Each component forms a synergistic effect of functional complementarity and mechanistic coupling, blocking the retinol degradation pathway from multiple dimensions. Specifically, the solvent oil constructs a continuous hydrophobic environment, directly isolating water and oxygen from contacting retinol molecules; the antioxidant efficiently captures free radicals generated during oxidation, interrupting the degradation chain reaction; the polyglycerol emulsifier and a specific proportion of solid lipids synergistically form a dense and stable interfacial film, maintaining the system's dispersion uniformity; the polyol balances the system's hydration state, reduces interfacial tension, and helps improve the system's tolerance; the polymer acts as a rigid framework supporting the hybrid structure, preventing carrier collapse and drug leakage. The components do not act independently, but rather form a comprehensive three-dimensional protective barrier through multiple synergistic mechanisms such as hydrophobic isolation, free radical scavenging, interface stabilization, structural support, and hydration balance. This significantly improves the stability of retinol itself and the overall formulation system, effectively inhibiting the oxidative degradation, isomerization, and activity loss of retinol during storage and use. It fundamentally overcomes the technical challenges of poor stability, short shelf life, and rapid efficacy decay of traditional retinol formulations, providing an innovative solution for the efficient and stable application of retinol in anti-aging cosmetics.

[0006] Optionally, by weight percentage, the components include 5-15% retinol, 10-20% solvent oil, 0.1-1% antioxidant, 2-4.5% emulsifier, 1-2% lipid, 10-15% polyol, 0.05-0.2% polymer, and the balance being water.

[0007] Optionally, the emulsifier includes polyglycerol emulsifiers.

[0008] The polyglycerol emulsifiers include one or more of polyglycerol-10 myristate, polyglycerol-10 stearate, and polyglycerol-10 oleate.

[0009] The solvent oil includes one or more of the following: glyceryl caprylic / capric ester, tridecane, squalane, jojoba ester, isooctyl palmitate, ethylhexyl stearate, dioctyl carbonate, isononyl isononanoate, and propylheptyl octanoate.

[0010] The solvent oil includes one or more of glyceryl caprylic / decanoic acid ester and tridecane.

[0011] Optionally, the solvent oil comprises glyceryl caprylic / decanoate and tridecane, wherein the weight ratio of glyceryl caprylic / decanoate to tridecane is (10-15):(3-6).

[0012] The antioxidants include one or more of tocopherol, BHT (2,6-di-tert-butyl-p-cresol), BHA (tert-butyl-p-hydroxyanisole), and pentaerythritol tetra(bis-tert-butyl-hydroxyhydrocinnamic acid) ester.

[0013] Optionally, the antioxidant includes one or both of tocopherol and BHT.

[0014] The polyols include at least two of glycerol, propylene glycol, butylene glycol, pentanediol, and hexanediol.

[0015] Optionally, the polyol includes glycerol and hexanediol, wherein the weight ratio of glycerol to hexanediol is 10:(1-3).

[0016] The polymer includes one or two of xanthan gum, sphingosine gum, sclerotium gum, carbomer, acrylate cross-linked polymers, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, and sodium polyacrylate.

[0017] The polymer includes one or both of xanthan gum and sphingosine mycelium gum.

[0018] The lipids include one or more of cetearyl oleate, sorbitan oleate, glyceryl stearate, glyceryl behenate, pentaerythritol distearate, stearyl alcohol, behenate, palmitol, and myristol.

[0019] Optionally, the lipids include cetearyl oleate and sorbitan oleate, wherein the weight ratio of cetearyl oleate to sorbitan oleate is 3:(1-3).

[0020] A second aspect of the present invention provides a method for preparing a composition, comprising the following steps: Retinol, antioxidant, and solvent oil are mixed and dissolved to obtain an oil phase; emulsifier, lipid, and polyol are mixed and dissolved to obtain a surfactant phase; the surfactant phase and polymer are added to water, dispersed evenly, and then the oil phase is added to obtain a coarse dispersion; the coarse dispersion is dispersed using a microfluidic process to obtain a composition.

[0021] The pressure of the microjet process is 800-1000 bar.

[0022] The microfluidic process is repeated 1-3 times.

[0023] The hydration kinetic diameter of the composition is 100-200 nm.

[0024] A third aspect of the present invention provides an application of the composition in the preparation of cosmetics.

[0025] Beneficial effects 1. This invention, through the compounding of specific retinol, solvent oil, antioxidant, emulsifier, lipid, polyol and polymer, can significantly improve the stability of retinol and the system, and solve the problem of easy oxidation and degradation of retinol.

[0026] 2. By limiting the emulsifier to polyglycerol, this invention, combined with lipid and polymer hybrid encapsulation, can effectively reduce the skin irritation of retinol, thus effectively solving the defects of retinol's strong irritation and limited applicable population.

[0027] 3. By defining the preparation method of the composition and combining it with high-pressure microfluidic technology, this invention can ensure the long-term stability of the particle size, dispersibility and pH of the nanosystem.

[0028] 4. This invention improves the skin permeability of retinol by regulating the composition to form uniform nanoparticles with a hydrodynamic diameter of 100-200 nm, thus solving the bottleneck of low penetration efficiency and difficulty in exerting efficacy of retinol formulations.

[0029] 5. The composition prepared by this invention has a better anti-aging effect when used in the cosmetics field. It can significantly increase skin elasticity, reduce wrinkles around the eyes, and increase dermal thickness and density. Attached Figure Description

[0030] Figure 1 The appearance of the sample in Example 1.

[0031] Figure 2 The changes in retinol retention rate after adding it to the emulsion in Example 1 and Comparative Example 1 and storing it at 45°C for 12 weeks are shown.

[0032] Figure 3 The permeability of Example 1 and Comparative Example 1 was compared by adding them to the essence and conducting a diffusion cell experiment.

[0033] Figure 4 This is a comparison of the permeability of the serum after adding it to the essence and emulsifying it with retinol, as shown in Example 1, in a diffusion cell experiment.

[0034] Figure 5 Examples 1 and Comparative Example 1 were added to face creams, and the subjects used them for 4 weeks to observe changes in facial skin elasticity.

[0035] Figure 6 Examples 1 and Comparative Example 1 were added to face creams, and the changes in the size of crow's feet were observed in subjects after 4 weeks of use.

[0036] Figure 7Examples 1 and Comparative Example 1 were added to face creams, and the subjects used them for 4 weeks to observe changes in the depth of crow's feet.

[0037] Figure 8 The image shows the changes in crow's feet wrinkles in subjects after 4 weeks of use, as described in Example 1, which was added to a face cream.

[0038] Figure 9 Example 1 and Comparative Example 1 were added to face creams respectively, and the changes in the thickness of the dermal layer of the facial skin were observed in the subjects after 4 weeks of use.

[0039] Figure 10 Examples 1 and Comparative Example 1 were added to face creams, and the changes in the density of the dermal layer of facial skin were observed in subjects after 4 weeks of use.

[0040] Figure 11 Example 1 was added to a face cream, and the changes in facial dermal protein fiber simulation diagrams were observed in subjects after 4 weeks of use. Detailed Implementation

[0041] Examples 1-2, Comparative Examples 1-4 A lipid-polymer composition encapsulating retinol, the components of which are shown in Table 1.

[0042] Table 1

[0043] A method for preparing a lipid-polymer composition loaded with retinol.

[0044] The preparation method of Example 1 is as follows: Retinol, tocopherol, tridecane, and glyceryl caprylic / capric acid ester are heated to 50°C until completely dissolved to obtain an oil phase. Glycerin, polyglycerol-10 myristate, cetearyl oleate, and sorbitan oleate are heated to 80°C until uniformly dissolved to obtain a surfactant phase. The surfactant phase and xanthan gum are added to water and homogenized at 4500 rpm for 5 min. Then, the oil phase is added and homogenized at 4500 rpm for 5 min to obtain a coarse dispersion. The coarse dispersion is subjected to high-pressure shearing using a microfluidic jet at a pressure of 1000 bar for 3 times to obtain the desired product. Figure 1 The composition shown.

[0045] The preparation method of Example 2 is as follows: Retinol, tocopherol, and glyceryl caprylic / capric acid ester were heated to 50°C until completely dissolved to obtain an oil phase. Glycerol, polyglycerol-10 myristate, cetearyl oleate, and sorbitan oleate were heated to 80°C until uniformly dissolved to obtain a surfactant phase. The surfactant phase and xanthan gum were added to water and homogenized at 4500 rpm for 5 min. Then, the oil phase was added and homogenized at 4500 rpm for 5 min to obtain a coarse dispersion. The coarse dispersion was subjected to high-pressure shearing using a microjets at a pressure of 1000 bar twice to obtain the composition.

[0046] The preparation method of Comparative Example 1 is as follows: retinol, tocopherol, tridecane, butanediol, and polysorbate-20 are heated to 50°C until completely dissolved to obtain an oil phase. The oil phase and xanthan gum are added to water and homogenized at 4500 rpm for 5 min to obtain a coarse dispersion. The coarse dispersion is subjected to high-pressure shearing using a microjets at a pressure of 1000 bar for 3 times to obtain the composition.

[0047] The preparation method of Comparative Example 2 is as follows: Retinol, tocopherol, tridecane, and glyceryl caprylic / capric acid ester were heated to 50°C until completely dissolved to obtain an oil phase. Glycerin, polyglycerol-10 myristate, cetearyl oleate, and sorbitan oleate were heated to 80°C until uniformly dissolved to obtain a surfactant phase. The surfactant phase was added to water and homogenized at 4500 rpm for 5 min. Then, the oil phase was added and homogenized at 4500 rpm for 5 min to obtain a coarse dispersion. The coarse dispersion was subjected to high-pressure shearing using a microjets at a pressure of 1000 bar for 3 times to obtain the composition.

[0048] The preparation method of Comparative Example 3 is as follows: Retinol, tocopherol, tridecane, and glyceryl caprylic / capric acid ester were heated to 50°C until completely dissolved to obtain an oil phase. Glycerol and polyglycerol-10 myristate were heated to 50°C until uniformly dissolved to obtain a surfactant phase. The surfactant phase and xanthan gum were added to water and homogenized at 4500 rpm for 5 min. Then, the oil phase was added and homogenized at 4500 rpm for 5 min to obtain a coarse dispersion. The coarse dispersion was subjected to high-pressure shearing using a microjets at a pressure of 1000 bar for 3 times to obtain the composition.

[0049] The preparation method of Comparative Example 4 is as follows: Retinol, tocopherol, tridecane, and glyceryl caprylic / capric acid ester were heated to 50°C until completely dissolved to obtain the oil phase. Glycerol, polyglycerol-10 myristate, cetearyl oleate, and sorbitan oleate were heated to 80°C until uniformly dissolved to obtain the surfactant phase. The surfactant phase and xanthan gum were added to water and homogenized at 4500 rpm for 5 min. Then, the oil phase was added and homogenized at 4500 rpm for 5 min to obtain a coarse dispersion. The coarse dispersion was subjected to high-pressure shearing using a microjets at a pressure of 1000 bar for 3 times to obtain the composition.

[0050] Performance testing methods The compositions prepared in the examples and comparative examples were subjected to the following performance tests. Performance test experiment 1: The appearance changes of Examples 1-2 and Comparative Examples 1-4 after being stored at 4℃, 25℃ and 50℃ for 8 weeks are listed in Table 2.

[0051] Test method: Examples 1-2 and Comparative Examples 1-4 were placed at 4℃, 25℃ and 45℃ respectively for 8 weeks, and the appearance was observed for discoloration, layering, sedimentation, oiling and other conditions.

[0052] Test Results: As shown in Table 2, Examples 1 and 2 showed essentially no change in appearance after 8 weeks of storage, exhibiting good stability. Comparative Example 1 showed significant color deepening under high-temperature conditions, indicating poor stability. Comparative Example 2 showed solid precipitation under low-temperature conditions, indicating poor stability. Comparative Examples 3 and 4 both showed oil exudation at high temperatures, indicating poor stability. Therefore, the emulsifier, solid lipids, and polymers in Examples 1 and 2 are essential components, and their proportions cannot be arbitrarily changed.

[0053] Table 2

[0054] Performance Test 2: The particle size (hydration dynamic diameter), PDI (polydispersity index), and pH stability of Example 1 after high and low temperature storage are listed in Table 3.

[0055] Particle size and PDI testing methods: The sample was diluted with pure water at a mass concentration of 0.1%, and then dynamic light scattering method was used. The accumulation model was based on ISO 22412 Particle size analysis – Dynamic light scattering (DLS). The light intensity was used to characterize the hydration dynamic diameter and PDI. Three parallel measurements were taken and the average value was taken. The results are expressed as mean ± standard deviation.

[0056] pH test method: According to GB / T13531.1 General test method for cosmetics, pH value determination is performed by dilution method to determine the pH value of the sample as a 10% aqueous solution.

[0057] Test Results: The test results are shown in Table 1. During storage at 4℃, 25℃, and 45℃ for 8 weeks, the particle size distribution of Example 1 remained between 126-135 nm, with very small fluctuations. The PDI fluctuated between 0.07 and 0.14, indicating high monodispersity of the system. The pH remained stable within the range of 4-5. Therefore, Example 1 exhibits excellent structural stability, with all indicators varying within a small range.

[0058] Table 3

[0059] Performance Test Experiment 3: Retinol Retention Rate of Examples 1 and 1 after Adding to Emulsion and Storage Test Method: Take emulsion samples (Table 4), add 0.3 wt% of Example 1 and 0.3 wt% of Comparative Example 1 respectively, and then place both samples at 45℃. The retinol content is determined by HPLC at the initial, 4-week, and 12-week stages. The HPLC method is mainly based on "T / SHRH043 Determination of all-trans retinol and its derivatives in cosmetics and raw materials by high-performance liquid chromatography". The retention rate is calculated as follows: Retention rate = (Stable retinol content / Initial sample retinol content) * 100%.

[0060] Test results: see Figure 2 After 12 weeks, the retinol retention rate of the sample in Example 1 was 82.72%, while that of the sample in Comparative Example 1 was 40.37%. The former was about 105% higher than the latter, indicating that Example 1 significantly improved the stability of retinol.

[0061] Homemade lotion recipe table 4:

[0062] Process: After pre-mixing glycerol and xanthan gum in phase A, add them to water while stirring. Add the remaining components in phase A, homogenize at 3000 rpm for 5 minutes, and heat to 75°C. Heat phase B to 75°C until completely dissolved, then add it to phase A and homogenize at 6000 rpm for 5 minutes. Phase C was pre-dispersed in a dispersion disc at 1000 rpm for 30 minutes, and then phases AB were added and homogenized at 6000 rpm for 3 minutes. After pre-dissolving phase D, add phases ABC, homogenize at 6000 rpm for 3 minutes, and then cool to below 45°C; Add phase E to phases ABCD, homogenize at 6000 rpm for 3 minutes, and then continue cooling to below 30°C.

[0063] Performance Test Experiment 4: Permeability Comparison between Example 1 and Comparative Example 1 Test methods: Sample A (retinol content 0.25 wt%) was obtained by adding 5 wt% of Example 1 to the essence sample; Sample B (retinol content 0.25 wt%) was obtained by adding 5 wt% of Comparative Example 1 to the essence sample; Sample C was obtained by adding 0.25 wt% of retinol to the emulsion sample. Samples A and B were subjected to Franz diffusion cell experiments, and the retinol content was measured at 1 h, 2 h, 4 h, 8 h, and 12 h. The results were expressed as permeability. Samples A and C were subjected to Franz diffusion cell experiments, and the retinol content was measured at 1 h, 2 h, 4 h, 8 h, and 12 h. The results were expressed as cumulative permeation. The Franz diffusion cell experiment was mainly based on "T / SHBA002 Cosmetic Evaluation In Vitro Skin Permeation Test Method". Strat-M artificial membranes were used for skin testing. The retinol content test method was mainly based on "T / SHRH043 Determination of All-trans Retinol and its Derivatives in Cosmetics and Raw Materials by High Performance Liquid Chromatography".

[0064] Test results: such as Figure 3 As shown, the permeability of Example 1 was increased by more than 50% compared to Comparative Example 1 at 4h, 8h, and 12h, indicating that the permeability of Example 1 was significantly higher than that of Comparative Example 1. Figure 4 As shown, the permeability of the sample with added retinol in Example 1 was more than 38 times higher than that of the emulsion at both 8h and 12h, proving that the permeability of the composition was significantly higher than that of the unencapsulated retinol.

[0065] Performance Test Experiment 5: Comparison of IC50 values ​​of keratinocytes in Example 1 and Comparative Example 1 Test method: Refer to the literature<De Bai,et al.Pharmaceutics,2023,15(3):731.> The IC50 values ​​of keratinocytes in Example 1 and Comparative Example 1 were determined.

[0066] Test results: The IC50 value of Example 1 was 0.02347%, and the IC50 value of Comparative Example 1 was 0.01379%. Therefore, the former is about 70% safer for human keratinocytes than the latter.

[0067] Performance Test Experiment 6: Human Patch Experiment of Example 1 and Comparative Example 1 Test method: 0.2% of Example 1 and 0.2% of Comparative Example 1 were added to the essence samples respectively, and then both samples were sent for patch testing. The patch test was mainly conducted in accordance with the "Cosmetic Safety Technical Specifications (2015 Edition)". Number of participants: 30.

[0068] Test results: Adding the essence sample of Example 1 resulted in 0 people experiencing irritation, while adding the essence sample of Comparative Example 1 resulted in 4 people experiencing a Grade 1 reaction. Therefore, the composition of Example 1 can significantly reduce the irritation of retinol.

[0069] Performance Test Experiment 7: Human Anti-aging Efficacy Experiment of Example 1 and Comparative Example 1 Test Method: 1 wt% of Example 1 and 1 wt% of Comparative Example 1 were added to the face cream samples, and 10 subjects were tested for 4 weeks. The main test items were facial elasticity, crow's feet size, crow's feet depth, dermal thickness, and dermal density, mainly according to the "T / CAB0152-2022 Test Methods for Seven Efficacy Items of Cosmetics: Anti-wrinkle, Firming, Moisturizing, Oil Control, Repairing, Nourishing, and Soothing". The initial values ​​of each parameter were set to 100%, and the results were expressed as the rate of change after 2 and 4 weeks.

[0070] Test results: such as Figure 5 As shown, the face cream of Example 1 demonstrated better improvement in skin elasticity compared to the face cream of Comparative Example 1 at both 2 and 4 weeks. Figure 6 As shown, the face cream of Example 1 reduced the size of crow's feet more than the face cream of Comparative Example 1 at 2 and 4 weeks. Figure 7 As shown, the face cream of Example 1 reduced the depth of crow's feet more than the face cream of Comparative Example 1 at 2 and 4 weeks. Figure 8 As shown, the face cream in Example 1 had a significant effect on improving the wrinkles around the eyes of the subjects. Figure 9 As shown, the face cream of Example 1 showed a more significant increase in dermal thickness at 2 and 4 weeks compared to the face cream of Comparative Example 1. Figure 10 As shown, the face cream of Example 1 showed a more significant effect on increasing dermal density compared to the face cream of Comparative Example 1 at 2 and 4 weeks. Figure 11 As shown, the dermal protein fiber density of the subjects treated with the face cream in Example 1 significantly increased within 4 weeks. Therefore, Example 1 demonstrates a better anti-aging effect than Comparative Example 1, significantly improving skin elasticity, reducing wrinkle size and depth, and increasing dermal thickness and density.

Claims

1. A lipid-polymer composition comprising retinol, characterized in that, By mass percentage, the components include 1-15% retinol, 10-20% solvent oil, 0.1-1% antioxidant, 1-4.5% emulsifier, 1-2% lipid, 10-20% polyol, 0.05-0.5% polymer, and the balance being water.

2. The composition according to claim 1, characterized in that, The emulsifier includes polyglycerol emulsifiers.

3. The composition according to claim 2, characterized in that, The polyglycerol emulsifiers include one or more of polyglycerol-10 myristate, polyglycerol-10 stearate, and polyglycerol-10 oleate.

4. The composition according to claim 1, characterized in that, The solvent oil includes one or both of glyceryl caprylic / decanoic acid ester and tridecane.

5. The composition according to claim 4, characterized in that, The solvent oil comprises glyceryl caprylic / decanoate and tridecane, wherein the weight ratio of glyceryl caprylic / decanoate and tridecane is (10-15):(3-6).

6. The composition according to claim 1, characterized in that, The polyols include at least two of glycerol, propylene glycol, butylene glycol, pentanediol, and hexanediol.

7. The composition according to claim 6, characterized in that, The polyol comprises glycerol and hexanediol, wherein the weight ratio of glycerol to hexanediol is 10:(1-3).

8. A method for preparing the composition according to any one of claims 1-7, characterized in that, Includes the following steps: Retinol, antioxidant, and solvent oil are mixed and dissolved to obtain the oil phase; emulsifier, lipid, and polyol are mixed and dissolved to obtain the surfactant phase; the surfactant phase and polymer are added to water, dispersed evenly, and then the oil phase is added to obtain a coarse dispersion; The coarse dispersion was dispersed using a microfluidic process to obtain the composition.

9. The method for preparing the composition according to claim 8, characterized in that, The hydration kinetic diameter of the composition is 100-200 nm.

10. An application of the composition according to any one of claims 1-7, characterized in that, It is used in the preparation of cosmetics.

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