A dispensing device for brucellosis vaccine dilution

Abstract

The present application belongs to the technical field of vaccine dilution and liquid preparation, and particularly relates to a medicine preparation device for brucellosis vaccine dilution, aiming at how to realize full-closed protection, self-adaptive bottle body fixation and mechanical precise proportion adjustment, and proposing the following scheme, which comprises a transparent protective shell, a mixed dilution tank, a fixing frame assembly, a three-way conveying unit and an adjustable liquid pumping assembly. The present application constructs a closed operation environment, completely isolates aerosol risk, and the adjustable liquid pumping assembly can realize different proportion pumping of the liquid in the vaccine bottle and the diluent bottle, thereby meeting different dilution concentration medicine preparation requirements, ensuring the accuracy of vaccine dilution concentration, and the three-way conveying unit can realize the communication of different pipelines through switching, thereby realizing the conversion of dilution mode, medicine injection mode and disinfection mode, and the operation personnel can easily complete the vaccine dilution and medicine injection work.

Description

Technical Field

[0001] This invention relates to a drug preparation device, specifically a drug preparation device for diluting brucellosis vaccine, belonging to the field of vaccine dilution preparation technology. Background Technology

[0002] Brucellosis, a serious zoonotic disease, continues to be prevalent in densely populated livestock areas. Its pathogen, Brucella, can be transmitted through aerosols and skin contact, posing a significant infection risk to herders, veterinarians, and other occupational groups. Currently, control of the disease mainly relies on live vaccine inoculation, such as Brucella live vaccine (I) (M5 strain) and live vaccine (II) (M5-90 strain). These vaccines are prepared using attenuated strains, and although they have good immunogenicity, they still retain some pathogenicity. Traditional vaccine dilution methods have several drawbacks: Firstly, diluting vaccines with open syringes easily forms aerosols, posing a significant threat to the health of operators, as Brucella vaccines are attenuated live vaccines and still possess some pathogenicity in humans. Secondly, ordinary dispensing devices cannot accurately control the amount of diluent, potentially leading to inaccurate vaccine concentrations and affecting immunization efficacy.

[0003] In existing technologies, such as the safe high-precision continuous vaccine dispensing / injector disclosed in CN106691622A, although a closed dilution circuit is constructed and the liquid tank, injection gun and vaccine vial are connected through a three-way conversion valve, its circuit relies on an external hose connection. In high-humidity breeding environments, the hose is prone to detachment due to collisions with livestock, causing pathogens to leak out. Moreover, the unstable fixation of the vial body causes puncture deviation. Vaccine vials of different sizes (such as 100ml freeze-dried vials and 500ml diluent vials) are prone to shaking on traditional snap-fit ​​fixing frames, causing the puncture needle to deviate from the center of the rubber stopper and puncture the vial body. Another example is the vaccine inoculation device disclosed in CN206548642U, which adopts an inverted snap-fit ​​design. Although the vaccine vial mouth is fixed by snap-fit ​​parts, it lacks an adaptive clamping mechanism. In actual operation, the tilt of the vial body will lead to inconsistent puncture depths, increasing the risk of contamination by rubber stopper debris. Secondly, the dilution ratio control accuracy is insufficient. The error rate between manual stepwise aspiration of diluent and vaccine is generally >10%, directly affecting the immunization effect. Although existing technologies use dual pistons to independently control the flow, both hands must operate the plunger simultaneously. In continuous injection scenarios, operator fatigue can easily lead to dosage fluctuations, especially for vaccines requiring precise proportions, such as Brucella live vaccine (I). A dosage deviation of 5% can result in a decrease in the immunization protection rate of about 30%. Furthermore, manual switching of catheter valves is required to complete dilution and administration, and the tubing must be disassembled and rinsed during disinfection, with residual droplets easily contaminating the environment. In addition, the negative pressure inside the lyophilized bottle is not fully utilized, often resulting in 10%-15% diluent residue, reducing the effective concentration of the vaccine. Summary of the Invention

[0004] This invention provides a dispensing device for diluting brucellosis vaccines to solve the technical problems of how to achieve fully enclosed protection, adaptive bottle fixation, and precise mechanical ratio adjustment, so as to completely block the biological exposure chain in the operation of live brucellosis vaccines and ensure the accuracy of immunization.

[0005] The present invention achieves the above objectives through the following technical solution: a dispensing device for diluting brucellosis vaccine, comprising a transparent protective shell, a mixing and dilution tank and two sets of fixing frame assemblies disposed inside the transparent protective shell, the fixing frame assemblies respectively fixingly holding vaccine bottles and diluent bottles, a three-way conveying unit disposed at the upper end of the mixing and dilution tank, and an adjustable liquid extraction assembly disposed between the mixing and dilution tank and the fixing frame assemblies. The fixing frame assembly includes a fixing base, a limiting ring, and an inlet puncture needle. The inlet puncture needle is fixedly connected to the fixing base with its tip pointing upwards. The limiting ring is movably positioned directly above the inlet puncture needle. The mouths of the vaccine bottle and the diluent bottle are both inverted and locked in the limiting ring. The fixing frame assembly is equipped with hydraulic clamping units on both sides of the body of the vaccine bottle and the diluent bottle. A telescopic anti-drip unit is sleeved on the outside of the inlet puncture needle. The adjustable liquid extraction assembly includes a liquid extraction housing, an L-shaped movable push rod, and two negative pressure liquid extraction tubes. The tube bodies of the two negative pressure liquid extraction tubes are fixedly connected inside the liquid extraction housing. The L-shaped movable push rod is movably positioned inside the liquid extraction housing. The pushing ends of the two negative pressure liquid extraction tubes movably abut against the outer side of the horizontal and vertical rods of the L-shaped movable push rod.

[0006] As a further embodiment of the present invention: a top cover is movably and snapped into the upper opening of the transparent protective shell, two sealed gloves are connected to the front shell of the transparent protective shell, a vent is provided on the top cover, and an air filter is fixedly connected inside the vent.

[0007] As a further embodiment of the present invention: two support rods are vertically connected to the base of the fixed base. The support rods are movably fitted with a movable sleeve and a sleeve return spring, with the sleeve return spring located below the movable sleeve. A limiting ring is connected between the two movable sleeves. A liquid delivery pipe is provided between the fixed frame assembly and the adjustable liquid extraction assembly. One end of the liquid delivery pipe is embedded in the base of the fixed base and connected to the liquid inlet puncture needle. The other end of the liquid delivery pipe is inserted into the liquid extraction shell and connected to the negative pressure liquid extraction pipe. A one-way valve for infusion is installed on the body of the liquid delivery pipe.

[0008] As a further embodiment of the present invention: the hydraulic clamping unit includes a first hydraulic telescopic rod, a first liquid guide tube, and a second hydraulic telescopic rod. The first hydraulic telescopic rod is fixedly connected to the outer side of the movable sleeve. The movable rod of the first hydraulic telescopic rod abuts against the upper surface of the fixed base. The second hydraulic telescopic rod is fixedly connected to the top of the support rod in a horizontally opposite manner. The first liquid guide tube communicates between the first and second hydraulic telescopic rods. A clamping plate is fixedly connected to the front end of the movable rod of the second hydraulic telescopic rod. An airbag is connected to the inner side of the clamping plate. It should be noted that the part of the airbag that contacts the body of the vaccine bottle or diluent bottle is coated with an anti-slip particle coating to form a textured surface.

[0009] As a further embodiment of the present invention: the telescopic anti-drip unit includes a telescopic sleeve and a rubber baffle. The telescopic sleeve is sleeved around the liquid inlet puncture needle. The bottom end of the telescopic sleeve is fixedly connected to the upper surface of the fixed base. The upper end of the telescopic sleeve is connected to the rubber baffle. A compression spring is also provided inside the telescopic sleeve, which is sleeved on the outside of the liquid inlet puncture needle. The two ends of the compression spring abut against the rubber baffle and the fixed base.

[0010] As a further embodiment of the present invention: the inner walls of both sides of the liquid extraction shell are provided with fixed limiting guide grooves arranged vertically, and the vertical rod of the L-shaped movable push rod is provided with movable limiting guide grooves on both sides. A limiting slider is movably connected between the movable limiting guide groove on the vertical rod of the L-shaped movable push rod and the fixed limiting guide groove arranged horizontally. A limiting slider is also movably connected between the movable limiting guide groove on the horizontal rod of the L-shaped movable push rod and the fixed limiting guide groove arranged vertically.

[0011] As a further embodiment of the present invention: the bent part of the L-shaped movable push rod is connected to a connecting ear, and a fourth hydraulic telescopic rod is rotatably connected to the connecting ear. An arc-shaped limiting groove is opened on one side of the liquid extraction shell. A threaded positioning post is connected to the outer rod of the fourth hydraulic telescopic rod. The threaded positioning post moves through the arc-shaped limiting groove, and a locking nut is threaded on the post located on the outer side of the liquid extraction shell. A third hydraulic telescopic rod is fixedly connected to the upper end of the liquid extraction shell. A second liquid guide tube is connected between the third hydraulic telescopic rod and the fourth hydraulic telescopic rod.

[0012] As a further embodiment of the present invention: the negative pressure suction tube includes a suction outer tube, a suction piston, and a suction inner rod. The suction piston is movably installed inside the suction outer tube. The tail end of the suction outer tube is connected to the other end of the liquid delivery tube. Part of the suction inner rod is movably inserted into the suction outer tube, and one end of the suction inner rod located inside the suction outer tube is connected to the suction piston. Multiple suction one-way valves are installed on the suction piston. A ball bearing base is connected to one end of the suction inner rod located outside the suction outer tube. A ball bearing is movably embedded in the ball bearing base. A return spring is sleeved on the rod body of the suction inner rod located outside the suction outer tube. A sliding groove is opened on the outer wall of the L-shaped movable push rod, and the ball bearing is movably locked in the sliding groove. The outer side of the liquid extraction shell is equipped with a main liquid outlet pipe and two branch liquid outlet pipes. One end of the branch liquid outlet pipe is connected to the front end of the negative pressure liquid extraction pipe, and the other end of each branch liquid outlet pipe is connected to the main liquid outlet pipe.

[0013] As a further embodiment of the present invention: a vertically arranged liquid level meter is provided inside the mixing and dilution tank, a stirring base plate is provided at the bottom of the mixing and dilution tank, a plurality of centrally symmetrical stirring blades are connected to the upper surface of the stirring base plate, a micro stirring motor is connected to the center of the lower surface of the stirring base plate, and the body of the micro stirring motor is fixedly embedded in the bottom surface of the mixing and dilution tank.

[0014] As a further embodiment of the present invention: the three-way delivery unit provided at the upper end of the mixing and dilution tank includes a three-way T-type ball valve, a dosing conduit and a negative pressure dosing pipe. One horizontal port of the three-way T-type ball valve is connected to the other end of the liquid outlet main pipe, and the other horizontal port of the three-way T-type ball valve is connected to the dosing conduit. The vertical port of the three-way T-type ball valve is connected to the tank conduit. The other end of the tank conduit is inserted into the bottom of the mixing and dilution tank. The body of the dosing conduit is connected to a dosing one-way valve. The negative pressure dosing pipe has the same structure as the negative pressure suction pipe. The bottom end of the negative pressure dosing pipe is connected to the other end of the dosing conduit. The upper end of the negative pressure dosing pipe is connected to a dosing outlet pipe, and the dosing end of the dosing outlet pipe is connected to a dosing puncture needle.

[0015] The beneficial effects of this invention are: 1. This invention is equipped with a transparent protective shell, a mixing and dilution tank, a fixing frame assembly, a three-way delivery unit, and an adjustable liquid extraction assembly. By setting up a mixing and dilution tank, two sets of fixing frame assemblies, and a three-way delivery unit connected to the mixing and dilution tank through the adjustable liquid extraction assembly inside the transparent protective shell, a closed operating environment is constructed to completely isolate the risk of aerosols. The adjustable liquid extraction assembly can extract liquids from the vaccine bottle and the diluent bottle in different proportions, thereby meeting the needs of different dilution concentrations and ensuring the accuracy of vaccine dilution concentration. The three-way delivery unit can switch between different pipelines, thereby realizing the conversion between dilution mode, drug delivery mode, and disinfection mode. Operators can easily complete the vaccine dilution and drug delivery work. 2. The fixing frame assembly of this invention includes a fixing base, a limiting ring, and a liquid inlet puncture needle. The fixing frame assembly is equipped with hydraulic clamping units on both sides of the vaccine bottle and the diluent bottle. A telescopic anti-drip unit is sleeved on the outside of the liquid inlet puncture needle. The hydraulic clamping unit stabilizes bottles of different sizes through a mechanical self-adaptive structure, avoiding puncture deviation or detachment caused by bottle shaking during operation. The telescopic anti-drip unit forms a dynamic seal around the puncture needle, which can effectively solve the safety hazards of traditional dilution methods. 3. The adjustable liquid extraction component of this invention includes a liquid extraction shell, an L-shaped movable push rod, and two negative pressure liquid extraction tubes. The L-shaped movable push rod of the adjustable liquid extraction component can be linked with the two negative pressure liquid extraction tubes. That is, by changing the moving angle of the L-shaped movable push rod, the moving direction of the L-shaped movable push rod can be adjusted, thereby adjusting the moving distance of the L-shaped movable push rod in the x-axis direction and the moving distance in the y-axis direction, realizing the adjustment of the liquid extraction amplitude of the two negative pressure liquid extraction tubes. This enables single-handed control of simultaneous quantitative and proportional extraction of dual liquid sources, solving the dosage error caused by traditional step-by-step operation. The overall structure integrates the high-risk vaccine dilution process into a fully enclosed system, fundamentally blocking the possibility of operator contact with pathogens, and effectively solving the problem of insufficient accuracy in traditional dilution methods. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall appearance and structure of the present invention; Figure 2 This is a schematic diagram of the y-axis cross-sectional structure of the transparent protective shell of the present invention; Figure 3 This is a schematic diagram of the internal structure of the transparent protective shell of the present invention; Figure 4 This is a schematic diagram of the connection structure between the vaccine vial, the diluent vial, and the fixing frame assembly of the present invention; Figure 5 This is a schematic diagram of the fixing frame assembly structure of the present invention; Figure 6 For the present invention Figure 5 Schematic diagram of the cross-sectional structure at point A in the middle; Figure 7 This is a schematic diagram of the external structure of the adjustable liquid extraction component of the present invention; Figure 8 This is a schematic cross-sectional view of the adjustable liquid extraction assembly of the present invention; Figure 9 This is a schematic diagram of the disassembled liquid-drawing shell and L-shaped movable push rod of the present invention; Figure 10 This is a schematic diagram of the connection structure between the L-shaped movable push rod and the fourth hydraulic telescopic rod of the present invention; Figure 11 This is a schematic diagram of the cross-sectional structure of the L-shaped movable push rod of the present invention; Figure 12 This is a schematic diagram of the L-shaped movable push rod of the present invention being pushed at a 45° tilt angle; Figure 13 This is a schematic diagram of the L-shaped movable push rod of the present invention being pushed at a 30° tilt angle; Figure 14 This is a schematic diagram of the cross-sectional structure of the negative pressure suction pipe of the present invention; Figure 15 This is a schematic cross-sectional view of the mixing and dilution tank of the present invention.

[0017] In the diagram: 1. Transparent protective shell; 11. Top cover; 12. Sealed glove; 13. Ventilation port; 14. Air filter; 2. Vaccine vial; 3. Diluent vial; 4. Fixing frame assembly; 41. Fixing base; 42. Clamping plate; 43. Limiting ring; 44. Support rod; 45. Movable sleeve; 46. First hydraulic telescopic rod; 47. First liquid guide tube; 48. Second hydraulic telescopic rod; 49. Airbag; 410. Telescopic sleeve; 411. Injection puncture needle; 412. Liquid delivery tube; 413. Infusion check valve; 414. Rubber baffle; 415. Compression spring; 416. Sleeve return spring; 5. Adjustable suction assembly; 51. Suction shell; 52. Third hydraulic telescopic rod; 53. Arc-shaped limiting groove; 54. Arc-shaped dial; 55. Outlet branch tube; 56. Outlet main tube; 57. Negative 571. Suction tube; 572. Suction piston; 573. Suction rod; 574. Suction return spring; 575. Ball bearing; 576. Suction check valve; 577. Ball bearing base; 58. L-shaped movable push rod; 59. Fourth hydraulic telescopic rod; 510. Second guide tube; 511. Fixed limit guide groove; 512. Limit slider; 513. Connecting lug; 514. Movable limit. 515. Guide groove; 516. Threaded positioning post; 517. Slide groove; 518. Locking nut; 6. Mixing and dilution tank; 61. Liquid level meter; 62. Stirring base plate; 63. Stirring blade; 64. Miniature stirring motor; 65. Three-way T-type ball valve; 66. Inner conduit of the tank; 67. Dosing conduit; 68. Dosing check valve; 69. Negative pressure dosing pipe; 610. Dosing outlet pipe; 611. Dosing puncture needle. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Example 1 like Figures 1 to 15As shown, a dispensing device for diluting brucellosis vaccine includes a transparent protective shell 1. Inside the transparent protective shell 1, there is a mixing and dilution tank 6 and two sets of fixing frame assemblies 4. The fixing frame assemblies 4 respectively fix vaccine bottles 2 and diluent bottles 3. A three-way delivery unit is provided at the upper end of the mixing and dilution tank 6. An adjustable liquid extraction assembly 5 is provided between the mixing and dilution tank 6 and the fixing frame assemblies 4. By setting up the mixing and dilution tank 6, the two sets of fixing frame assemblies 4 inside the transparent protective shell 1, and the three-way delivery unit connected to the mixing and dilution tank 6 through the adjustable liquid extraction assembly 5, a closed operating environment is constructed to completely isolate the risk of aerosols. The adjustable liquid extraction assembly 5 can extract liquids from the vaccine bottles 2 and diluent bottles 3 in different proportions, thereby meeting the needs of different dilution concentrations and ensuring the accuracy of vaccine dilution concentration. The three-way delivery unit can switch between different pipelines to realize the conversion of dilution mode, drug delivery mode and disinfection mode. Operators can easily complete the vaccine dilution and drug delivery work. The fixing frame assembly 4 includes a fixing base 41, a limiting ring 43, and an inlet puncture needle 411. The inlet puncture needle 411 is fixedly connected to the fixing base 41 with its tip pointing upwards. The limiting ring 43 is movably positioned directly above the inlet puncture needle 411. The mouths of the vaccine bottle 2 and the diluent bottle 3 are both inverted and held in the limiting ring 43. The fixing frame assembly 4 is equipped with hydraulic clamping units on both sides of the body of the vaccine bottle 2 and the diluent bottle 3. A telescopic anti-drip unit is fitted on the outside of the inlet puncture needle 411. The hydraulic clamping unit stabilizes bottles of different sizes through a mechanical self-adaptive structure, avoiding puncture deviation or detachment caused by bottle shaking during operation. The telescopic anti-drip unit forms a dynamic seal around the puncture needle, which can effectively solve the safety hazards of traditional dilution methods. The adjustable liquid extraction assembly 5 includes a liquid extraction housing 51, an L-shaped movable push rod 58, and two negative pressure liquid extraction tubes 57. The tube bodies of the two negative pressure liquid extraction tubes 57 are fixedly connected inside the liquid extraction housing 51. The L-shaped movable push rod 58 is movably mounted in the liquid extraction housing 51. The pushing ends of the two negative pressure liquid extraction tubes 57 movably abut against the outer sides of the horizontal and vertical rod bodies of the L-shaped movable push rod 58. The L-shaped movable push rod 58 of the adjustable liquid extraction assembly 5 can link the two negative pressure liquid extraction tubes 57, that is, by changing the moving angle of the L-shaped movable push rod 58, the liquid extraction can be adjusted using... The adjustment of the L-shaped movable push rod 58 allows for corresponding adjustment of its movement distance along the x-axis and y-axis, thereby adjusting the suction amplitude of the two negative pressure suction tubes 57. This enables single-handed control of simultaneous quantitative and proportional extraction of dual liquid sources, resolving dosage errors caused by traditional step-by-step operations. The overall structure integrates the high-risk vaccine dilution process into a fully enclosed system, fundamentally preventing operators from coming into contact with pathogens and effectively addressing the lack of accuracy in traditional dilution methods.

[0020] Example 2 Improvements based on Example 1: like Figure 1 and Figure 2 As shown, a top cover 11 is movably and snap-fitted to the upper opening of the transparent protective shell 1. Two sealing gloves 12 are connected to the front of the transparent protective shell 1. The top cover 11 has a ventilation opening 13, and an air filter 14 is fixedly connected inside the ventilation opening 13. It should be noted that a sealing strip may be provided at the connection between the upper opening of the transparent protective shell 1 and the top cover 11. The ventilation opening 13 of the top cover 11 is connected to an external ventilation system. The transparent protective shell 1 is made of high-strength, leak-proof material, and the seal between the top cover 11 and the opening of the transparent protective shell 1 is... The design ensures airtightness within the outer casing. Combined with the external filtration system of the vent 13, it creates a negative pressure environment for directional air exhaust. The air filter 14 can trap aerosol particles ≥0.3μm, with a trapping efficiency of >99.97% for Brucella 0.5-0.7μm particles, eliminating the risk of atomization and diffusion of live vaccines. The sealed gloves 12 allow operators to flexibly perform actions such as puncture and mixing while also achieving physical isolation. This design elevates the safety level of the operating environment to the standard of a biosafety cabinet, making it particularly suitable for grassroots farms and other locations without advanced protective facilities.

[0021] like Figures 3 to 6 As shown, two support rods 44 are vertically connected to the base of the fixed base 41. A movable sleeve 45 and a sleeve return spring 416 are movably fitted onto the body of each support rod 44, with the sleeve return spring 416 located below the movable sleeve 45. A limiting ring 43 is connected between the two movable sleeves 45. A liquid delivery pipe 412 is provided between the fixed frame assembly 4 and the adjustable liquid extraction assembly 5. One end of the liquid delivery pipe 412 is embedded in the base of the fixed base 41 and connected to the liquid inlet puncture needle 411. The other end of the liquid delivery pipe 412 is inserted into the liquid extraction shell 51 and connected to the negative pressure liquid extraction pipe 57. A delivery device is installed on the body of the liquid delivery pipe 412. The liquid one-way valve 413, with its sleeve return spring 416, forms a spring return structure between the support rod 44 and the movable sleeve 45, thereby giving the limiting ring 43 a buffer stroke: when the vaccine bottle 2 or diluent bottle 3 is pressed down, the bottle mouth pushes the limiting ring 43 down, the movable sleeve 45 compresses the sleeve return spring 416, and the infusion puncture needle 411 is inserted into the rubber stopper of the bottle mouth at a uniform speed, avoiding bottle breakage or rubber stopper debris contamination caused by violent puncture. The infusion one-way valve 413 ensures that the liquid can only be drawn out in one direction, preventing backflow and cross-contamination. This structure significantly improves the safety and success rate of puncture operation, especially with stronger compatibility with glass bottles and thick rubber stopper bottles.

[0022] Furthermore, the hydraulic clamping unit includes a first hydraulic telescopic rod 46, a first liquid guide tube 47, and a second hydraulic telescopic rod 48. The first hydraulic telescopic rod 46 is fixedly connected to the outer side of the movable sleeve 45. The movable rod of the first hydraulic telescopic rod 46 abuts against the upper surface of the fixed base 41. The second hydraulic telescopic rod 48 is fixedly connected to the top of the support rod 44 in a horizontally facing position. The first liquid guide tube 47 connects the first hydraulic telescopic rod 46 and the second hydraulic telescopic rod 48. A clamping plate 42 is fixedly connected to the front end of the movable rod of the second hydraulic telescopic rod 48. An airbag 49 is connected to the inner side of the clamping plate 42. It should be noted that the part of the airbag 49 that contacts the body of the vaccine bottle 2 or the diluent bottle 3 is coated with an anti-slip particle coating to form a textured surface. The first hydraulic telescopic rod 46 is driven by the downward pressure of the bottle body and transmits hydraulic pressure to the second hydraulic telescopic rod 48 through the first liquid guide tube 47. The hydraulic telescopic rod 48 pushes the clamping plate 42 to horizontally clamp the bottle body, realizing automatic linkage between vertical downward pressure and horizontal clamping without the need for an additional power source. The anti-slip particle coating on the surface of the airbag 49 increases the coefficient of friction, preventing the bottle body from rotating or slipping. The clamping force is adaptively adjusted according to the bottle weight. For example, the clamping force generated by a 500ml diluent bottle (approximately 500g) is 5 times that of a 100ml vaccine bottle (approximately 100g), ensuring the stability of large-capacity bottles. This mechanical feedback mechanism avoids the risk of electronic sensor failure and is suitable for high-humidity, dusty farm environments. It should be noted that the first hydraulic telescopic rod 46 and the second hydraulic telescopic rod 48 can be the hydraulic telescopic rod involved in the oil filtration device of the hydraulic telescopic rod with announcement number CN213298477U, entitled "A Hydraulic Telescopic Rod", which includes a hydraulic sleeve, connecting plate, slider, telescopic end, first inlet, and second inlet.

[0023] Furthermore, the telescopic anti-drip unit includes a telescopic sleeve 410 and a rubber baffle 414. The telescopic sleeve 410 is sleeved around the inlet puncture needle 411, and the bottom end of the telescopic sleeve 410 is fixedly connected to the upper surface of the fixed base 41. The upper end of the telescopic sleeve 410 is connected to the rubber baffle 414. A compression spring 415 is also provided inside the telescopic sleeve 410, which is sleeved on the outside of the inlet puncture needle 411. The two ends of the compression spring 415 abut against the rubber baffle 414 and the fixed base 41. In its natural state, the rubber baffle 414 covers the inlet puncture needle. When the needle tip of the head 411 is punctured, the bottle mouth squeezes the rubber baffle 414, causing the telescopic sleeve 410 to contract and the compression spring 415 to store energy. When the bottle is removed, the compression spring 415 is released, pushing the rubber baffle 414 to return to its original position. The rubber material of the rubber baffle 414 instantly closes the needle hole. This structure improves the anti-drip efficiency by more than 90% compared to the traditional silicone pad, especially for the dripping problem of high-viscosity vaccines such as oil adjuvants. In addition, the rubber material of the rubber baffle 414 ensures a tight fit with the needle wall of the liquid inlet puncture needle 411, so that no liquid remains on the needle wall, which is far cleaner than manual wiping.

[0024] like Figure 3 , Figures 7 to 14As shown, the inner walls of both sides of the liquid extraction shell 51 are provided with vertically arranged fixed limiting guide grooves 511. The vertical shaft of the L-shaped movable push rod 58 is provided with movable limiting guide grooves 514 on both sides. A limiting slider 512 is movably connected between the movable limiting guide grooves 514 on the vertical shaft of the L-shaped movable push rod 58 and the horizontally arranged fixed limiting guide grooves 511. A limiting slider 512 is also movably connected between the movable limiting guide grooves 514 on the horizontal shaft of the L-shaped movable push rod 58 and the vertically arranged fixed limiting guide grooves 511. The fixed limiting guide grooves 511 and movable limiting guide grooves 514 form a double guide rail constraint through the limiting slider 512, eliminating the liquid extraction volume deviation caused by the swaying of the L-shaped movable push rod 58, thus improving the operating accuracy compared to a handle without a guide structure. This is particularly suitable for Brucella vaccines requiring high-precision mixing ratios.

[0025] Furthermore, the bent portion of the L-shaped movable push rod 58 is connected to a connecting lug 513, and a fourth hydraulic telescopic rod 59 is rotatably connected to the connecting lug 513. An arc-shaped limiting groove 53 is provided on one side of the liquid extraction housing 51. A threaded positioning post 515 is connected to the outer body of the fourth hydraulic telescopic rod 59. The threaded positioning post 515 movably passes through the arc-shaped limiting groove 53, and a locking nut 517 is threaded onto the outer side of the threaded positioning post 515. A third hydraulic telescopic rod 52 is fixedly connected to the upper end of the liquid extraction housing 51. A second liquid guide pipe 510 connects the third hydraulic telescopic rod 52 and the fourth hydraulic telescopic rod 59. The angle of the fourth hydraulic telescopic rod 59 is adjusted by rotation through the connecting lug 513. The arc-shaped limiting groove 53 matches a 90° rotation stroke. The threaded positioning post 515 and the locking nut 517 fix the angle of the fourth hydraulic telescopic rod 59, preventing process confusion caused by accidental switching. The extension and retraction of the fourth hydraulic telescopic rod 59 is controlled by the third hydraulic... The telescopic rod 52 is hydraulically controlled via the second liquid guide pipe 510. Therefore, by adjusting the fourth hydraulic telescopic rod 59 to different angle positions, the L-shaped movable push rod 58 can be pushed in different directions, thereby adjusting the movement distance of the L-shaped movable push rod 58 along the x-axis and y-axis. The pushing ends of the two negative pressure suction pipes 57 are movably pressed against the outer sides of the horizontal and vertical rods of the L-shaped movable push rod 58, thus adjusting the suction amplitude of the two negative pressure suction pipes 57. This allows for simultaneous extraction of liquid from the vaccine bottle 2 and the diluent bottle 3 while ensuring adjustment of the extraction ratio to meet different dilution ratio requirements. It should be noted that the third hydraulic telescopic rod 52 and the fourth hydraulic telescopic rod 59 can be the hydraulic telescopic rod involved in the oil filtration device of the hydraulic telescopic rod with announcement number CN213298477U, including a hydraulic sleeve, connecting plate, slider, telescopic end, first inlet, and second inlet, as shown below. Figure 12 and Figure 13As shown, when the L-shaped movable push rod 58 is pushed at a 45° tilt angle, the ratio of the horizontal movement distance to the vertical movement distance of the L-shaped movable push rod 58 is x1:y1; when the L-shaped movable push rod 58 is pushed at a 30° tilt angle, the ratio of the horizontal movement distance to the vertical movement distance of the L-shaped movable push rod 58 is x2:y2. That is, the L-shaped movable push rod 58 can have a relative ratio of horizontal movement distance to vertical movement distance when pushed at different tilt angles, which means that the two negative pressure liquid extraction tubes 57 can have a corresponding pushing amplitude ratio, and thus have a relative liquid extraction ratio, so as to realize the adjustment of the extraction ratio to meet different dilution ratio requirements.

[0026] Furthermore, the negative pressure suction tube 57 includes a suction outer tube 571, a suction piston 572, and a suction inner rod 573. The suction piston 572 is movably installed inside the suction outer tube 571, and the tail end of the suction outer tube 571 is connected to the other end of the liquid delivery tube 412. Part of the suction inner rod 573 is movably inserted into the suction outer tube 571, and one end of the suction inner rod 573 located inside the suction outer tube 571 is connected to the suction piston 572. Multiple suction check valves 576 are installed on the suction piston 572. One end of the suction inner rod 573 located outside the suction outer tube 571 is connected to a ball bearing base 577, which is movably embedded with... The ball bearing 575 and the inner suction rod 573 are located outside the outer suction tube 571 and are fitted with a return spring 574. The outer wall of the L-shaped movable push rod 58 is provided with a sliding groove 516. The ball bearing 575 is movably locked in the sliding groove 516. The one-way valve 576 of the suction piston 572 ensures one-way liquid output. The ball bearing 575 rolls in the sliding groove 516 of the L-shaped movable push rod 58, which ensures that the L-shaped movable push rod 58 can move easily when it is displaced relative to the negative pressure suction tube 57. At the same time, the return spring 574 ensures that the suction piston 572 can automatically return to its original position and the return speed is constant, which facilitates continuous liquid suction. The outer side of the liquid extraction shell 51 is provided with a main liquid outlet 56 and two branch liquid outlet pipes 55. One end of the branch liquid outlet pipe 55 is connected to the front end of the negative pressure liquid extraction pipe 57, and the other end of the branch liquid outlet pipe 55 is connected to the main liquid outlet 56. It should be noted that the inner diameter of the main liquid outlet 56 is larger than the inner diameter of the branch liquid outlet pipe 55 to reduce fluid resistance and avoid air bubble retention, thus meeting the requirements for micro-dilution of vaccines.

[0027] like Figure 3 and Figure 15As shown, a vertically arranged liquid level meter 61 is installed inside the mixing and dilution tank 6. A stirring base plate 62 is installed at the bottom of the mixing and dilution tank 6. Multiple sets of centrally symmetrical stirring blades 63 are connected to the upper surface of the stirring base plate 62. A micro stirring motor 64 is connected to the center of the lower surface of the stirring base plate 62, and the body of the micro stirring motor 64 is fixedly embedded in the bottom surface of the mixing and dilution tank 6. It should be noted that the liquid level meter 61 can be a capacitive sensor and is connected to the signal of the external control system. The micro stirring motor 64 drives the stirring base plate 62 to rotate, thereby driving the centrally symmetrically distributed stirring blades 63 to generate axial vortices, improving the mixing efficiency. The liquid level meter 61 provides real-time feedback of the liquid volume to the control system. The embedded motor design at the bottom of the tank eliminates dynamic sealing components, eliminates the risk of leakage, improves efficiency compared to traditional magnetic stirring, and ensures vaccine activity by eliminating metal parts from contacting the liquid.

[0028] Furthermore, the three-way delivery unit installed at the upper end of the mixing and dilution tank 6 includes a three-way T-ball valve 65, a dosing conduit 67, and a negative pressure dosing pipe 69. One horizontal port of the three-way T-ball valve 65 is connected to the other end of the liquid outlet main pipe 56, and the other horizontal port of the three-way T-ball valve 65 is connected to the dosing conduit 67. The vertical port of the three-way T-ball valve 65 is connected to an internal conduit 66, the other end of which is inserted into the bottom of the mixing and dilution tank 6. The body of the dosing conduit 67 is connected to a dosing check valve 68. The negative pressure dosing pipe 69 has the same structure as the negative pressure suction pipe 57, and the bottom end of the negative pressure dosing pipe 69 is connected to the other end of the dosing conduit 67. The upper end of the negative pressure dosing tube 69 is connected to the dosing outlet tube 610, and the dosing end of the dosing outlet tube 610 is connected to the dosing puncture needle 611. The 90° switching of the three-way T-type ball valve 65 realizes the conversion between "dilution-dosing-disinfection" modes: the dilution mode connects the outlet tube 56 to the inner conduit 66; the dosing mode connects the inner conduit 66 to the dosing conduit 67; the disinfection mode connects to the external disinfectant pipeline. The conical tip of the dosing puncture needle 611 reduces tissue damage and, together with the negative pressure dosing tube 69, achieves precise drug administration of 0.01ml / s. The overall coefficient is reduced by 60% compared with the existing veterinary dilution equipment, and there are no open links throughout the process.

[0029] Working principle: Before operation, open the top cover 11 of the transparent protective shell 1, and invert the vaccine bottle 2 and diluent bottle 3 into the limiting ring 43 of the fixing frame assembly 4. When the bottle body is pressed down, the movable sleeve 45 compresses the sleeve return spring 416, so that the liquid inlet puncture needle 411 punctures the rubber stopper at a uniform speed; at the same time, the downward pressure of the bottle body drives the first hydraulic telescopic rod 46, which transmits hydraulic pressure to the second hydraulic telescopic rod 48 through the first liquid guide tube 47, pushing the clamping plate 42 and the air bag 49 to horizontally clamp the bottle body, achieving self-adaptive stability; during the puncture process, the bottle mouth squeezes the rubber baffle 414 to retract the telescopic sleeve 410, and the compression spring 415 stores energy; During dilution, the three-way T-type ball valve 65 switches to the dilution mode, the fourth hydraulic telescopic rod 59 is rotated to the preset angle, and fixed by the arc-shaped limiting groove 53 and the threaded positioning column 515. Based on the tilt angle of the fourth hydraulic telescopic rod 59, the L-shaped movable push rod 58 is pushed to move. Its horizontal and vertical rods respectively squeeze the balls 575 of the two negative pressure suction pipes 57, which drives the inner suction rod 573 to push the suction piston 572. The vaccine and diluent are simultaneously drawn into the outlet branch pipe 55 through the liquid delivery pipe 412 via the suction check valve 576. The mixed liquid is input into the three-way T-type ball valve 65 through the outlet main pipe 56 and enters the mixing and dilution tank 6 through the tank conduit 66. The micro stirring motor 64 drives the stirring base plate 62 to drive the stirring blades 63 to mix in a vortex. The liquid level meter 61 monitors the capacity in real time. When administering medication, switch the three-way T-type ball valve 65 to the medication administration mode. The mixture is then precisely output through the medication administration conduit 67, the negative pressure medication administration tube 69, and the medication administration puncture needle 611. During disinfection, the three-way T-type ball valve 65 is first switched to the dilution mode, and disinfectant is added to the diluent bottle 3. The disinfection process is the same as the dilution mode. Then, the three-way T-type ball valve 65 is switched to the dosing mode, and the disinfection process is the same as the dosing mode. The entire operation is completed through sealed gloves 12 inside the transparent protective shell 1, and the air filter 14 prevents aerosols from escaping.

[0030] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0031] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A dispensing device for diluting brucellosis vaccine, comprising a transparent protective shell (1), characterized in that: The transparent protective shell (1) contains a mixing and dilution tank (6) and two sets of fixing frame assemblies (4). The fixing frame assemblies (4) respectively fix the vaccine bottle (2) and the diluent bottle (3). The upper end of the mixing and dilution tank (6) is provided with a three-way conveying unit. An adjustable liquid extraction assembly (5) is provided between the mixing and dilution tank (6) and the fixing frame assembly (4). The fixing frame assembly (4) includes a fixing base (41), a limiting ring (43) and an inlet puncture needle (411). The inlet puncture needle (411) is fixedly connected to the fixing base (41) with its tip pointing upward. The limiting ring (43) is movably positioned directly above the inlet puncture needle (411). The mouths of the vaccine bottle (2) and the diluent bottle (3) are both placed in the limiting ring (43) in an upside-down position. The fixing frame assembly (4) is provided with hydraulic clamping units on both sides of the body of the vaccine bottle (2) and the diluent bottle (3). The outside of the inlet puncture needle (411) is fitted with a telescopic anti-drip unit. The adjustable liquid extraction assembly (5) includes a liquid extraction shell (51), an L-shaped movable push rod (58), and two negative pressure liquid extraction tubes (57). The tube bodies of the two negative pressure liquid extraction tubes (57) are fixedly connected inside the liquid extraction shell (51). The L-shaped movable push rod (58) is movably arranged in the liquid extraction shell (51). The pushing ends of the two negative pressure liquid extraction tubes (57) are movably abutted against the outer side of the horizontal and vertical rod bodies of the L-shaped movable push rod (58).

2. The dispensing apparatus for diluting brucellosis vaccine according to claim 1, characterized in that: The upper opening of the transparent protective shell (1) is movably connected to a top cover (11). Two sealed gloves (12) are connected to the front shell of the transparent protective shell (1). The top cover (11) has a vent (13). An air filter (14) is fixedly connected inside the vent (13).

3. The dispensing apparatus for diluting brucellosis vaccine according to claim 1, characterized in that: Two support rods (44) are vertically connected to the base of the fixed base (41). The support rods (44) are movably fitted with a movable sleeve (45) and a sleeve return spring (416). The sleeve return spring (416) is located below the movable sleeve (45). The limiting ring (43) is connected between the two movable sleeves (45). A liquid delivery pipe (412) is provided between the fixed frame assembly (4) and the adjustable liquid extraction assembly (5). One end of the liquid delivery pipe (412) is embedded in the base of the fixed base (41) and is connected to the liquid inlet puncture needle (411). The other end of the liquid delivery pipe (412) is inserted into the liquid extraction shell (51) and is connected to the negative pressure liquid extraction pipe (57). A one-way valve (413) is installed on the body of the liquid delivery pipe (412).

4. The dispensing apparatus for diluting brucellosis vaccine according to claim 3, characterized in that: The hydraulic clamping unit includes a first hydraulic telescopic rod (46), a first liquid guide tube (47), and a second hydraulic telescopic rod (48). The first hydraulic telescopic rod (46) is fixedly connected to the outer side of the movable sleeve (45). The movable rod of the first hydraulic telescopic rod (46) abuts against the upper surface of the fixed base (41). The second hydraulic telescopic rod (48) is fixedly connected to the top of the support rod (44) in a horizontally facing manner. The first liquid guide tube (47) is connected between the first hydraulic telescopic rod (46) and the second hydraulic telescopic rod (48). The front end of the movable rod of the second hydraulic telescopic rod (48) is fixedly connected to a clamping plate (42). An airbag (49) is connected to the inner side of the clamping plate (42). It should be noted that the part of the airbag (49) that contacts the body of the vaccine bottle (2) or the diluent bottle (3) is coated with an anti-slip particle coating to form a textured surface.

5. The dispensing apparatus for diluting brucellosis vaccine according to claim 4, characterized in that: The telescopic anti-drip unit includes a telescopic sleeve (410) and a rubber baffle (414). The telescopic sleeve (410) is sleeved around the liquid inlet puncture needle (411). The bottom end of the telescopic sleeve (410) is fixedly connected to the upper surface of the fixed base (41). The upper end of the telescopic sleeve (410) is connected to the rubber baffle (414). A compression spring (415) is also provided inside the telescopic sleeve (410) and sleeved on the outside of the liquid inlet puncture needle (411). The two ends of the compression spring (415) abut against the rubber baffle (414) and the fixed base (41).

6. The dispensing apparatus for diluting brucellosis vaccine according to claim 1, characterized in that: The inner walls of both sides of the liquid extraction shell (51) are provided with fixed limiting guide grooves (511) arranged vertically. The vertical rod of the L-shaped movable push rod (58) is provided with movable limiting guide grooves (514). The movable limiting guide grooves (514) on the vertical rod of the L-shaped movable push rod (58) and the fixed limiting guide grooves (511) are movably connected to the limiting sliders (512). The movable limiting guide grooves (514) on the horizontal rod of the L-shaped movable push rod (58) and the fixed limiting guide grooves (511) are also movably connected to the limiting sliders (512).

7. The dispensing apparatus for diluting brucellosis vaccine according to claim 6, characterized in that: The bent part of the L-shaped movable push rod (58) is connected to a connecting ear (513), and a fourth hydraulic telescopic rod (59) is rotatably connected to the connecting ear (513). An arc-shaped limiting groove (53) is opened on one side of the liquid extraction shell (51). A threaded positioning post (515) is connected to the outer rod of the fourth hydraulic telescopic rod (59). The threaded positioning post (515) moves through the arc-shaped limiting groove (53), and a locking nut (517) is threaded on the post outside the liquid extraction shell (51). A third hydraulic telescopic rod (52) is fixedly connected to the upper end of the liquid extraction shell (51). A second liquid guide pipe (510) is connected between the third hydraulic telescopic rod (52) and the fourth hydraulic telescopic rod (59).

8. The dispensing apparatus for diluting brucellosis vaccine according to claim 3, characterized in that: The negative pressure suction tube (57) includes a suction outer tube (571), a suction piston (572), and a suction inner rod (573). The suction piston (572) is movably installed inside the suction outer tube (571). The tail end of the suction outer tube (571) is connected to the other end of the liquid delivery tube (412). Part of the suction inner rod (573) is movably inserted inside the suction outer tube (571), and one end of the suction inner rod (573) inside the suction outer tube (571) is connected to the suction piston (572). The pumping piston (572) is equipped with multiple pumping one-way valves (576). The end of the pumping inner rod (573) located outside the pumping outer tube (571) is connected to a ball bearing base (577). The ball bearing base (577) is movably embedded with a ball bearing (575). A return spring (574) is sleeved on the rod body of the pumping inner rod (573) located outside the pumping outer tube (571). The outer side wall of the L-shaped movable push rod (58) is provided with a sliding groove (516). The ball bearing (575) is movably locked in the sliding groove (516). The outer side of the liquid extraction shell (51) is provided with a liquid outlet main pipe (56) and two liquid outlet branch pipes (55). One end of the liquid outlet branch pipe (55) is connected to the front end of the negative pressure liquid extraction pipe (57), and the other end of the liquid outlet branch pipe (55) is connected to the liquid outlet main pipe (56).

9. The dispensing apparatus for diluting brucellosis vaccine according to claim 1, characterized in that: The mixing and dilution tank (6) is equipped with a vertically arranged liquid level meter (61) inside the tank. The bottom of the mixing and dilution tank (6) is equipped with a stirring base plate (62). The upper surface of the stirring base plate (62) is connected to multiple sets of stirring blades (63) arranged in a centrally symmetrical manner. The center of the lower surface of the stirring base plate (62) is connected to a micro stirring motor (64), and the body of the micro stirring motor (64) is fixedly embedded in the bottom surface of the mixing and dilution tank (6).

10. The dispensing apparatus for diluting brucellosis vaccine according to claim 8, characterized in that: The three-way delivery unit installed at the upper end of the mixing and dilution tank (6) includes a three-way T-type ball valve (65), a dosing conduit (67), and a negative pressure dosing conduit (69). One horizontal port of the three-way T-type ball valve (65) is connected to the other end of the liquid outlet main pipe (56), and the other horizontal port of the three-way T-type ball valve (65) is connected to the dosing conduit (67). The vertical port of the three-way T-type ball valve (65) is connected to the tank inner conduit (66), and the other port of the tank inner conduit (66) is connected to the dosing conduit (67). One end is inserted into the bottom of the mixing and dilution tank (6). The body of the dosing conduit (67) is connected to a dosing check valve (68). The negative pressure dosing tube (69) has the same structure as the negative pressure suction tube (57). The bottom end of the negative pressure dosing tube (69) is connected to the other end of the dosing conduit (67). The upper end of the negative pressure dosing tube (69) is connected to a dosing outlet tube (610), and the dosing end of the dosing outlet tube (610) is connected to a dosing puncture needle (611).

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