Drug-loaded mesenchymal stem cell engineered preparation, preparation method and application thereof

By preparing drug-loaded mesenchymal stem cell engineered formulations, the problems of systemic drug distribution defects and unstable efficacy of MSCs in the treatment of systemic sclerosis have been solved. Targeted accumulation and local release of drugs at the lesion site have been achieved, enhancing anti-inflammatory and anti-fibrotic efficacy, reducing systemic side effects, and producing a stable synergistic therapeutic effect.

CN122140764APending Publication Date: 2026-06-05JILIN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN UNIVERSITY
Filing Date
2026-05-09
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing treatments for systemic sclerosis suffer from deficiencies in systemic drug distribution and unstable efficacy of mesenchymal stem cells (MSCs), resulting in significant side effects and short-lasting efficacy. Simple combination therapies cannot achieve precise drug accumulation and synergistic effects at the lesion site.

Method used

By preparing drug-loaded mesenchymal stem cell engineered formulations, hormonal drugs are loaded onto mesenchymal stem cells. Utilizing their targeted homing characteristics, the drugs are directly delivered to the lesion site, achieving potent local drug delivery. Furthermore, targeted delivery reduces systemic drug exposure, enhances the survival and function of MSCs, and realizes the spatiotemporal synergistic effect of drugs and cells.

Benefits of technology

It achieves targeted accumulation and local release of drugs at the lesion site, enhances anti-inflammatory and anti-fibrotic efficacy, significantly reduces the toxic side effects of systemic medication, and produces a stable synergistic therapeutic effect.

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Abstract

The application is suitable for the field of biological medicine technology, and provides a mesenchymal stem cell engineering preparation loaded with drugs, a preparation method and application, and comprises the following steps: cell pretreatment, MSCs sedimentation is obtained; methylprednisolone sodium succinate is weighed, filtered and sterilized, diluted to a working concentration, and placed on ice for standby; the MSCs sediment is resuspended, the cell density is adjusted to 2x10 6 cells / mL, the cell suspension and pre-cooled MPSS working solution are continuously mixed at a volume ratio of 1:1, so that the final concentration of MPSS is 4ug / uL, the loading process lasts for 24 hours±5 minutes, and the environmental temperature is maintained at 4℃±0.5℃; post-processing and preparation forming. In the application, MSCs are used as a drug delivery carrier to realize the lesion-targeted accumulation and local release of hormones and other drugs, so that the anti-inflammatory and anti-fibrosis effects are enhanced, the toxic and side effects caused by systemic medication are significantly reduced, and finally the synergistic treatment effect of "1+1>2" is achieved.
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