A clearing acne and acne-removing ointment for treating acne, its preparation method and application

Abstract

The present application relates to the technical field of traditional Chinese medicine compositions, in particular to a kind of Qinggua Xiaocuo ointment for treating acne and its preparation method and application.The Qinggua Xiaocuo ointment comprises 400-600 parts of rhubarb, 480-520 parts of sulfur, 150-180 parts of Chinese milk vetch, 380-420 parts of golden cypress, 70-100 parts of white and yellow, 70-90 parts of turmeric, 40-60 parts of Cape jasmine, 20-40 parts of ginger and magnolia officinalis, 20-40 parts of dried tangerine or orange peel, 20-40 parts of Chinese artichoke, 70-100 parts of white peony root, 10-25 parts of borneol, 20-40 parts of prepared rhizoma arisaematis, 150-180 parts of chapter dan, 300-350 parts of sophora, 300-350 parts of scutellaria, and 20-40 parts of licorice.The Qinggua Xiaocuo ointment provided by the present application has the effects of relieving redness, swelling and pain of inflammatory skin lesions, promoting the regression of nodules and pustules, and effectively preventing or treating acne.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a acne-clearing and acne-reducing ointment for treating acne, its preparation method, and its application. Background Technology

[0002] Acne, also known as acne vulgaris, is a common chronic inflammatory skin disease. It primarily affects the cheeks, forehead, and jawline, but can also spread to the chest, back, and shoulders. Clinically, it manifests as various skin lesions including comedones, papules, pustules, nodules, cysts, and scars, and is often accompanied by seborrhea. The pathogenesis of acne is complex, but it is closely related to factors such as abnormal androgen levels, excessive sebum secretion, abnormal keratinization of cells around the hair follicles, and inflammatory responses triggered by Propionibacterium acnes infection.

[0003] The typical symptoms of acne are lesions and seborrhea: in the early stages, they often manifest as whiteheads and blackheads, which can develop into inflammatory papules as the condition progresses, with some papules forming small pustules at their tips. These lesions not only severely affect the patient's appearance but also easily cause social distress and psychological stress, while negative emotions can further aggravate the condition, creating a vicious cycle. Among them, acne conglobata is one of the most severe types of acne, characterized by the dense fusion of deep inflammatory lesions (mainly nodules and cysts), often accompanied by significant pain, and is prone to leaving scars and pigmentation after healing, causing dual damage to the patient's skin health and mental well-being. Clinical treatment of acne conglobata requires a combination of drug therapy, physical therapy, and lifestyle interventions, and long-term standardized management is necessary to reduce the risk of recurrence.

[0004] Currently, the main clinical treatments for acne conglobata include topical antibiotics (such as clindamycin gel) and oral retinoids (such as isotretinoin). However, these drugs have significant limitations: long-term topical antibiotic use can easily lead to chronic skin damage and may also induce bacterial resistance; oral isotretinoin may cause various side effects such as elevated blood lipids, dry skin, and mucosal irritation, thus limiting its clinical application. Therefore, there is an urgent need for an acne treatment drug that is effective, safe, and has no obvious toxic side effects, which has significant clinical importance and application value. Summary of the Invention

[0005] The purpose of this invention is to provide an acne-clearing and acne-reducing ointment for treating acne, its preparation method and application. This ointment can effectively prevent or treat acne conglobata and has minimal toxic side effects.

[0006] To achieve the above objectives, the present invention provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: Rhubarb 400-600 parts, sulfur 480-520 parts, trichosanthes root 150-180 parts, phellodendron bark 380-420 parts, bletilla rhizome 70-100 parts, turmeric 70-90 parts, gardenia fruit 40-60 parts, magnolia bark 20-40 parts, tangerine peel 20-40 parts, atractylodes rhizome 20-40 parts, angelica root 70-100 parts, borneol 10-25 parts, processed arisaema rhizome 20-40 parts, cinnabar 150-180 parts, sophora root 300-350 parts, scutellaria root 300-350 parts, licorice root 20-40 parts.

[0007] In this invention, the acne-clearing and acne-reducing ointment for treating acne preferably comprises the following raw materials in parts by weight: rhubarb 520-540 parts, sulfur 490-510 parts, trichosanthes root 160-170 parts, phellodendron bark 400-410 parts, bletilla rhizome 80-90 parts, turmeric 80-88 parts, gardenia fruit 45-55 parts, magnolia bark 25-35 parts, tangerine peel 25-35 parts, atractylodes rhizome 25-35 parts, angelica root 80-90 parts, borneol 15-20 parts, processed arisaema rhizome 30-35 parts, cinnabar 160-170 parts, sophora root 320-330 parts, scutellaria root 320-330 parts, and licorice root 30-35 parts.

[0008] In this invention, the acne-clearing and acne-reducing ointment for treating acne more preferably comprises the following raw materials in parts by weight: 532 parts rhubarb, 500 parts sulfur, 169 parts trichosanthes root, 408 parts phellodendron bark, 85 parts bletilla rhizome, 85 parts turmeric, 50 parts gardenia fruit, 34 parts magnolia bark, 34 parts tangerine peel, 34 parts atractylodes rhizome, 85 parts angelica root, 17 parts borneol, 34 parts prepared arisaema rhizome, 169 parts cinnabar, 322 parts sophora root, 323 parts scutellaria root, and 34 parts licorice root.

[0009] In this invention, the *Zhangdan* refers to *Zhangdan* after roasting. The roasting method is not specifically limited and any roasting method known to those skilled in the art can be used.

[0010] This invention also provides a method for preparing the above-mentioned acne-clearing and acne-reducing ointment for treating acne, comprising the following steps: S1. Mix rhubarb, trichosanthes root, phellodendron bark, bletilla rhizome, turmeric, gardenia, magnolia bark, tangerine peel, atractylodes rhizome, angelica root, prepared arisaema rhizome, sophora root, scutellaria root, and licorice root, grind and sift to make medicinal powder; Sulfur and cinnabar are mixed, ground, and sieved to make a fine powder. The borneol is ground and sieved to obtain borneol powder; S2. Add the medicinal powder to water, soak, decoct to obtain a decoction, and concentrate to obtain a thick paste; S3. Melt the petroleum jelly and add it to the thick paste. Stir, then add the fine powder and borneol powder in sequence and continue stirring to obtain the acne-clearing and acne-reducing ointment for treating acne.

[0011] In this invention, the rhubarb, trichosanthes root, phellodendron bark, bletilla rhizome, turmeric, gardenia, magnolia bark, tangerine peel, atractylodes rhizome, angelica root, prepared arisaema rhizome, sophora root, scutellaria root, and licorice root mentioned in S1 all need to be dried before mixing. The drying temperature is 45-55℃, preferably 50℃, and the drying time is 4-6 hours, preferably 5 hours.

[0012] In this invention, the powder in S1 has a mesh size of 100-150 mesh, preferably 120 mesh; the fine powder has a mesh size of 100-150 mesh, preferably 120 mesh; and the borneol powder has a mesh size of 80-100 mesh, preferably 100 mesh.

[0013] In this invention, the mass-to-volume ratio of the medicinal powder to water in S2 is 1g:8-10mL, preferably 1g:9mL; the soaking temperature is preferably room temperature (18-30℃), the soaking time is 30-60min, preferably 45min; the decoction temperature is 90-95℃, preferably 92-95℃, the decoction time is 1-1.5h, preferably 1.2h.

[0014] In this invention, the concentration temperature in S2 is 60-70℃, preferably 65℃, the concentration vacuum degree is -0.06MPa to -0.04MPa, preferably -0.05MPa, and the concentration time is 1.5-2.5h, preferably 2h.

[0015] In this invention, after the petrolatum in S3 is melted, it is passed through a 400-mesh filter and then a thick paste is added.

[0016] In this invention, the mass ratio of petrolatum to thick paste in S3 is 1.5-2:1, preferably 2:1; the melting temperature is 75-85℃, preferably 80℃, and the melting holding time is 20-30 min, preferably 25 min; the stirring temperature is 50-60℃, preferably 55℃, the stirring speed is 150-250 r / min, preferably 200 r / min, and the stirring time is 30-40 min, preferably 35 min.

[0017] In this invention, the specific process of adding fine powder and borneol powder in sequence in S3 and continuing to stir includes: cooling the system temperature to 40-45℃, keeping the stirring speed constant, adding fine powder and stirring for 15-25 minutes, then adjusting the stirring speed to 260-300 r / min, adding borneol powder and stirring for 10-15 minutes to obtain acne-clearing and acne-reducing ointment for treating acne.

[0018] The present invention also provides the application of the above-mentioned acne-clearing and acne-reducing ointment in the preparation of acne prevention or treatment drugs.

[0019] The present invention has the following beneficial effects: This invention provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: rhubarb 400-600 parts, sulfur 480-520 parts, trichosanthes root 150-180 parts, phellodendron bark 380-420 parts, bletilla rhizome 70-100 parts, turmeric 70-90 parts, gardenia fruit 40-60 parts, magnolia bark 20-40 parts, tangerine peel 20-40 parts, atractylodes rhizome 20-40 parts, angelica root 70-100 parts, borneol 10-25 parts, prepared arisaema rhizome 20-40 parts, cinnabar 150-180 parts, sophora root 300-350 parts, scutellaria root 300-350 parts, and licorice root 20-40 parts.

[0020] The acne-clearing and acne-reducing ointment provided by this invention targets the core pathogenesis of severe acne—"heat, toxin, dampness, blood stasis, and nodules"—organically combining multiple effects such as clearing heat and detoxifying, drying dampness and astringing sores, promoting blood circulation and dispersing nodules, and reducing swelling and relieving pain. Specifically, the combination of rhubarb, sulfur, scutellaria, phellodendron, sophora flavescens, and gardenia constitutes the core of clearing heat, drying dampness, and detoxifying, inhibiting inflammation and reducing redness and swelling. The combination of turmeric, processed arisaema, trichosanthes kirilowii, and bletilla striata has the effects of promoting blood circulation, resolving phlegm, dispersing nodules, and reducing swelling, aiming to resolve deep skin lesions such as cysts and nodules. Borneol and angelica dahurica significantly enhance the local delivery efficiency of the active ingredients in the formula. Bletilla striata, cinnabar, and sulfur work together to exert an astringent effect, helping to reduce excessive sebum secretion, promote the absorption of inflammatory exudates, and dry skin lesions. Furthermore, the synergistic effect of turmeric, trichosanthes kirilowii, and bletilla striata promotes tissue repair and healing.

[0021] The acne-clearing and acne-reducing ointment provided by this invention has clearly defined functions of each component, which work synergistically to relieve redness, swelling, and pain of inflammatory skin lesions, promote the regression of nodules and pustules, and inhibit the progression of cysts. Moreover, it has a balanced medicinal effect, high safety, and few toxic side effects, and can effectively prevent or treat acne.

[0022] This invention also provides a method for preparing the above-mentioned acne-clearing and acne-reducing ointment for treating acne, comprising the following steps: S1. Rhubarb, Trichosanthes kirilowii, Phellodendron chinense, Bletilla striata, Curcuma longa, Gardenia jasminoides, Magnolia officinalis, Citrus reticulata, Atractylodes lancea, Angelica dahurica, processed Arisaema heterophyllum, Sophora flavescens, Scutellaria baicalensis, and Glycyrrhiza uralensis are mixed, ground, and sieved to make a medicinal powder; sulfur and cinnabar are mixed, ground, and sieved to make a fine powder; borneol is ground and sieved to obtain borneol powder; S2. The medicinal powder is added to water, soaked, and decocted to obtain a decoction, which is then concentrated to obtain a thick paste; S3. Vaseline is melted and added to the thick paste, stirred, and then the fine powder and borneol powder are added in sequence, and stirring is continued to obtain a acne-clearing and acne-reducing ointment for treating acne.

[0023] This product uses a topical ointment formulation, avoiding the risks associated with oral medications. By utilizing the soothing effect of petrolatum and the harmonizing effect of licorice, it not only retains the core pharmacological activity of the overall formula but also significantly improves the skin dryness, irritation, and other discomforts that may be caused by traditional topical medications. This enhances patient comfort and meets the requirements for long-term application.

[0024] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. Attached Figure Description

[0025] Figure 1 This is a comparison chart of the number of cured patients in the treatment group and the control group of this invention. Detailed Implementation

[0026] The present invention will be further described below with reference to the accompanying drawings and embodiments. Unless otherwise defined, the technical or scientific terms used in this invention should be understood in their ordinary sense by those skilled in the art. The features mentioned above or in the specific examples mentioned in this invention can be combined arbitrarily, and these specific embodiments are only used to illustrate the invention and are not intended to limit the scope of the invention.

[0027] Example 1 This embodiment provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: Rhubarb 532g, sulfur 500g, trichosanthes root 169g, phellodendron bark 408g, bletilla rhizome 85g, turmeric 85g, gardenia fruit 50g, magnolia bark 34g, tangerine peel 34g, atractylodes rhizome 34g, angelica root 85g, borneol 17g, prepared arisaema rhizome 34g, cinnabar 169g, sophora root 322g, scutellaria root 323g, licorice root 34g.

[0028] The preparation method of the above-mentioned acne-clearing and acne-reducing ointment includes the following steps: S1. Rhubarb, Trichosanthes kirilowii, Phellodendron chinense, Bletilla striata, Curcuma longa, Gardenia jasminoides, Magnolia officinalis, Citrus reticulata, Atractylodes lancea, Angelica dahurica, processed Arisaema heterophyllum, Sophora flavescens, Scutellaria baicalensis, and Glycyrrhiza uralensis are dried at 50°C for 5 hours, then mixed, ground, and passed through a 120-mesh sieve to make medicinal powder. The sulfur and cinnabar are mixed, ground, and passed through a 120-mesh sieve to make a fine powder; The borneol is ground and passed through a 100-mesh sieve to obtain borneol powder; S2. Take the above-mentioned medicinal powder and add it to 20000mL of water. Soak it at room temperature (25℃) for 45min, and then decoct it at 95℃ for 1.5h to obtain the decoction. Concentrate the decoction at 65℃ for 2h under a vacuum of -0.05MPa to obtain a thick paste. S3. Melt 4400g of petroleum jelly at 80℃ for 25min, pass it through a 400-mesh filter, then add the above thick paste, stir at 55℃ and 200r / min for 35min, then cool the system to 45℃, keep the stirring speed (200r / min) constant, add fine powder and stir for 15min, then adjust the stirring speed to 260r / min, add borneol powder and stir for 15min to obtain acne-clearing and acne-reducing ointment for treating acne.

[0029] Example 2: This embodiment provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: Rhubarb 600g, sulfur 510g, trichosanthes root 160g, phellodendron bark 400g, bletilla rhizome 80g, turmeric 90g, gardenia fruit 40g, magnolia bark 40g, tangerine peel 40g, atractylodes rhizome 40g, angelica root 100g, borneol 10g, prepared arisaema rhizome 20g, cinnabar 170g, sophora root 300g, scutellaria root 320g, licorice root 40g.

[0030] The preparation method of the above-mentioned acne-clearing and acne-reducing ointment includes the following steps: S1. Rhubarb, Trichosanthes kirilowii, Phellodendron chinense, Bletilla striata, Curcuma longa, Gardenia jasminoides, Magnolia officinalis, Citrus reticulata, Atractylodes lancea, Angelica dahurica, processed Arisaema heterophyllum, Sophora flavescens, Scutellaria baicalensis, and Glycyrrhiza uralensis are dried at 45°C for 4 hours, then mixed, ground, and passed through a 100-mesh sieve to make medicinal powder. The sulfur and cinnabar are mixed, ground, and passed through a 100-mesh sieve to make a fine powder; The borneol is ground and passed through a 100-mesh sieve to obtain borneol powder; S2. Take the above-mentioned medicinal powder and add it to 20000mL of water. Soak it at room temperature (25℃) for 60min, and then decoct it at 93℃ for 1h to obtain a decoction. Concentrate the decoction at 65℃ for 1.5h under a vacuum of -0.06MPa to obtain a thick paste. S3. Melt 4500g of petroleum jelly at 85℃ for 20min, pass it through a 400-mesh filter, then add the above thick paste, stir at 50℃ and 250r / min for 30min, then cool the system to 45℃, keep the stirring speed (250r / min) constant, add fine powder and stir for 20min, then adjust the stirring speed to 300r / min, add borneol powder and stir for 10min to obtain acne-clearing and acne-reducing ointment for treating acne.

[0031] Example 3: This embodiment provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: Rhubarb 400g, sulfur 480g, trichosanthes root 180g, phellodendron bark 380g, bletilla rhizome 100g, turmeric 80g, gardenia 45g, magnolia bark 20g, tangerine peel 20g, atractylodes rhizome 20g, angelica root 70g, borneol 25g, prepared arisaema rhizome 40g, cinnabar 150g, sophora root 350g, scutellaria root 350g, licorice root 30g.

[0032] The preparation method of the above-mentioned acne-clearing and acne-reducing ointment includes the following steps: S1. Rhubarb, Trichosanthes kirilowii, Phellodendron chinense, Bletilla striata, Curcuma longa, Gardenia jasminoides, Magnolia officinalis, Citrus reticulata, Atractylodes lancea, Angelica dahurica, processed Arisaema heterophyllum, Sophora flavescens, Scutellaria baicalensis, and Glycyrrhiza uralensis are dried at 55°C for 6 hours, then mixed, ground, and passed through a 150-mesh sieve to make medicinal powder. The sulfur and cinnabar are mixed, ground, and passed through a 150-mesh sieve to make a fine powder; The borneol is ground and passed through an 80-mesh sieve to obtain borneol powder; S2. Take the above-mentioned medicinal powder and add it to 20000mL of water. Soak it at room temperature (25℃) for 30min, and then decoct it at 90℃ for 1.5h to obtain a decoction. Concentrate the decoction at 60℃ for 2.5h under a vacuum of -0.04MPa to obtain a thick paste. S3. Melt 4000g of petroleum jelly at 85℃ for 20min, pass it through a 400-mesh filter, then add the above thick paste, stir at 150r / min at 60℃ for 40min, then cool the system to 40℃, keep the stirring speed (150r / min) constant, add fine powder and stir for 25min, then adjust the stirring speed to 260r / min, add borneol powder and stir for 15min to obtain acne-clearing and acne-reducing ointment for treating acne.

[0033] Example 4: This embodiment provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: Rhubarb 520g, sulfur 510g, trichosanthes root 170g, phellodendron bark 410g, bletilla rhizome 90g, turmeric 88g, gardenia fruit 55g, magnolia bark 35g, tangerine peel 35g, atractylodes rhizome 35g, angelica root 80g, borneol 15g, prepared arisaema rhizome 30g, cinnabar 160g, sophora root 320g, scutellaria root 330g, licorice root 35g.

[0034] The preparation method of the above-mentioned acne-clearing and acne-reducing ointment includes the following steps: S1. Rhubarb, Trichosanthes kirilowii, Phellodendron chinense, Bletilla striata, Curcuma longa, Gardenia jasminoides, Magnolia officinalis, Citrus reticulata, Atractylodes lancea, Angelica dahurica, processed Arisaema heterophyllum, Sophora flavescens, Scutellaria baicalensis, and Glycyrrhiza uralensis are dried at 55°C for 6 hours, then mixed, ground, and passed through a 100-mesh sieve to make medicinal powder. The sulfur and cinnabar are mixed, ground, and passed through a 100-mesh sieve to make a fine powder; The borneol is ground and passed through a 100-mesh sieve to obtain borneol powder; S2. Take the above-mentioned medicinal powder and add it to 20000mL of water. Soak it at room temperature (25℃) for 60min, and then decoct it at 92℃ for 1.2h to obtain a decoction. Concentrate the decoction at 60℃ for 1.5h under a vacuum of -0.04MPa to obtain a thick paste. S3. Melt 4000g of petroleum jelly at 75℃ for 30min, pass it through a 400-mesh filter, then add the above thick paste, stir at 55℃ and 200r / min for 40min, then cool the system to 40℃, keep the stirring speed (200r / min) constant, add fine powder and stir for 25min, then adjust the stirring speed to 260r / min, add borneol powder and stir for 15min to obtain acne-clearing and acne-reducing ointment for treating acne.

[0035] Example 5: This embodiment provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: Rhubarb 540g, sulfur 490g, trichosanthes root 160g, phellodendron bark 400g, bletilla rhizome 90g, turmeric 80g, gardenia fruit 45g, magnolia bark 25g, tangerine peel 25g, atractylodes rhizome 25g, angelica root 90g, borneol 20g, prepared arisaema rhizome 35g, cinnabar 170g, sophora root 330g, scutellaria root 330g, licorice root 30g.

[0036] The preparation method of the above-mentioned acne-clearing and acne-reducing ointment includes the following steps: S1. Rhubarb, Trichosanthes kirilowii, Phellodendron chinense, Bletilla striata, Curcuma longa, Gardenia jasminoides, Magnolia officinalis, Citrus reticulata, Atractylodes lancea, Angelica dahurica, processed Arisaema heterophyllum, Sophora flavescens, Scutellaria baicalensis, and Glycyrrhiza uralensis are dried at 55°C for 6 hours, then mixed, ground, and passed through a 150-mesh sieve to make medicinal powder. The sulfur and cinnabar are mixed, ground, and passed through a 120-mesh sieve to make a fine powder; The borneol is ground and passed through an 80-mesh sieve to obtain borneol powder; S2. Take the above-mentioned medicinal powder and add it to 20000mL of water. Soak it at room temperature (25℃) for 45min, and then decoct it at 95℃ for 1.2h to obtain a decoction. Concentrate the decoction at 60℃ for 1.5h under a vacuum of -0.05MPa to obtain a thick paste. S3. Melt 4000g of petroleum jelly at 85℃ for 20min, pass it through a 400-mesh filter, then add the above thick paste, stir at 55℃ and 200r / min for 40min, then cool the system to 40℃, keep the stirring speed (200r / min) constant, add fine powder and stir for 15min, then adjust the stirring speed to 300r / min, add borneol powder and stir for 10min to obtain acne-clearing and acne-reducing ointment for treating acne.

[0037] Example 6: This embodiment provides an acne-clearing and acne-reducing ointment for treating acne, comprising the following raw materials in parts by weight: Rhubarb 540g, sulfur 520g, trichosanthes root 150g, phellodendron bark 420g, bletilla rhizome 100g, turmeric 70g, gardenia fruit 60g, magnolia bark 40g, tangerine peel 40g, atractylodes rhizome 35g, angelica root 70g, borneol 20g, prepared arisaema rhizome 25g, cinnabar 165g, sophora root 325g, scutellaria root 300g, licorice root 20g.

[0038] The preparation method of the above-mentioned acne-clearing and acne-reducing ointment includes the following steps: S1. Rhubarb, Trichosanthes kirilowii, Phellodendron chinense, Bletilla striata, Curcuma longa, Gardenia jasminoides, Magnolia officinalis, Citrus reticulata, Atractylodes lancea, Angelica dahurica, processed Arisaema heterophyllum, Sophora flavescens, Scutellaria baicalensis, and Glycyrrhiza uralensis are dried at 50°C for 4 hours, then mixed, ground, and passed through a 100-mesh sieve to make medicinal powder. The sulfur and cinnabar are mixed, ground, and passed through a 150-mesh sieve to make a fine powder; The borneol is ground and passed through a 100-mesh sieve to obtain borneol powder; S2. Take the above-mentioned medicinal powder and add it to 20000mL of water. Soak it at room temperature (25℃) for 45min, and then decoct it at 95℃ for 1h to obtain a decoction. Concentrate the decoction at 60℃ for 2.5h under a vacuum of -0.06MPa to obtain a thick paste. S3. Melt 4000g of petroleum jelly at 75℃ for 20min, pass it through a 400-mesh filter, then add the above thick paste, stir at 60℃ and 250r / min for 40min, then cool the system to 40℃, keep the stirring speed (250r / min) constant, add fine powder and stir for 15min, then adjust the stirring speed to 300r / min, add borneol powder and stir for 10min to obtain acne-clearing and acne-reducing ointment for treating acne.

[0039] Test example: Take 100g of each of the acne-clearing and acne-reducing ointments prepared in Examples 1-6 above.

[0040] This invention systematically selected patients with aggregated acne of different ages and genders. The main medical history of the patients was: acne on the forehead, cheekbones and face, some of which were cystic or nodular, and some of which were merged into patches, with large pores.

[0041] The patients were randomly divided into a treatment group and a control group. The treatment group consisted of 60 patients, which were further divided into six treatment groups: treatment group 1, treatment group 2, treatment group 3, treatment group 4, treatment group 5, and treatment group 6. Each treatment group had 10 patients, including 5 male patients and 5 female patients. The male patients were aged 16-32 years, and the female patients were aged 16-34 years.

[0042] The control group consisted of 10 patients, including 5 males and 5 females. The male patients were aged 16-32 years, and the female patients were aged 16-34 years.

[0043] Treatment groups 1-6 were treated with the acne-clearing ointment prepared in Examples 1-6, respectively. The ointment was applied after cleansing the face with water, and then applied again every other day. The ointment was washed off with water after 40 minutes. The treatment course was 60 days.

[0044] (Treatment group 1 corresponds to the acne-clearing and acne-reducing ointment prepared in Example 1, treatment group 2 corresponds to the acne-clearing and acne-reducing ointment prepared in Example 2, treatment group 3 corresponds to the acne-clearing and acne-reducing ointment prepared in Example 3, treatment group 4 corresponds to the acne-clearing and acne-reducing ointment prepared in Example 4, treatment group 5 corresponds to the acne-clearing and acne-reducing ointment prepared in Example 5, and treatment group 6 corresponds to the acne-clearing and acne-reducing ointment prepared in Example 6).

[0045] The control group applied clindamycin gel to the affected area after cleansing their face in the morning and evening.

[0046] The clinical data statistics of the treatment effects in the above test group and the control group are shown in Table 1. The number of cured patients is shown in Table 1. Figure 1 .

[0047] Table 1. Clinical Data Statistics

[0048] Note: Cured: Acne cysts and nodules completely disappear; Significantly effective: Skin lesions disappear by more than 80%; Effective: Skin lesions disappear by more than 60%; Ineffective: Symptoms show no significant improvement, and skin lesions disappear by less than 20%.

[0049] From Table 1 and Figure 1It can be seen that the acne-clearing and acne-reducing ointment provided by this invention can effectively treat or alleviate acne, with high efficacy. In all treatment groups (1-6) with the acne-clearing and acne-reducing ointment, there were 0 ineffective cases, and the total effective rate (cured + significantly effective) was 100%, significantly better than the control group. Meanwhile, although the control group showed some effect in treating acne, skin dryness and redness occurred during the treatment course. Patients in the treatment group felt well after applying the ointment and did not experience any discomfort.

[0050] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A acne-clearing and acne-reducing ointment for treating acne, characterized in that, The raw materials include the following parts by weight: Rhubarb 400-600 parts, sulfur 480-520 parts, trichosanthes root 150-180 parts, phellodendron bark 380-420 parts, bletilla rhizome 70-100 parts, turmeric 70-90 parts, gardenia fruit 40-60 parts, magnolia bark 20-40 parts, tangerine peel 20-40 parts, atractylodes rhizome 20-40 parts, angelica root 70-100 parts, borneol 10-25 parts, processed arisaema rhizome 20-40 parts, cinnabar 150-180 parts, sophora root 300-350 parts, scutellaria root 300-350 parts, licorice root 20-40 parts.

2. The acne-clearing and acne-reducing ointment for treating acne according to claim 1, characterized in that, The acne-clearing and acne-reducing ointment for treating acne comprises the following ingredients in parts by weight: Rhubarb 520-540 parts, sulfur 490-510 parts, trichosanthes root 160-170 parts, phellodendron bark 400-410 parts, bletilla rhizome 80-90 parts, turmeric 80-88 parts, gardenia fruit 45-55 parts, magnolia bark 25-35 parts, tangerine peel 25-35 parts, atractylodes rhizome 25-35 parts, angelica root 80-90 parts, borneol 15-20 parts, processed arisaema rhizome 30-35 parts, cinnabar 160-170 parts, sophora root 320-330 parts, scutellaria root 320-330 parts, licorice root 30-35 parts.

3. The acne-clearing and acne-reducing ointment for treating acne according to claim 2, characterized in that, The acne-clearing and acne-reducing ointment for treating acne comprises the following ingredients in parts by weight: 532 parts rhubarb, 500 parts sulfur, 169 parts trichosanthes root, 408 parts phellodendron bark, 85 parts bletilla rhizome, 85 parts turmeric, 50 parts gardenia fruit, 34 parts magnolia bark, 34 parts dried tangerine peel, 34 parts atractylodes rhizome, 85 parts angelica root, 17 parts borneol, 34 parts prepared arisaema rhizome, 169 parts cinnabar, 322 parts sophora root, 323 parts scutellaria root, and 34 parts licorice root.

4. A pimple-clearing and acne-reducing ointment for treating acne according to claim 1, 2, or 3, characterized in that, The Zhangdan mentioned refers to Zhangdan after it has been roasted.

5. A method for preparing an acne-clearing and acne-reducing ointment according to any one of claims 1-4, characterized in that, Includes the following steps: S1. Mix rhubarb, trichosanthes root, phellodendron bark, bletilla rhizome, turmeric, gardenia, magnolia bark, tangerine peel, atractylodes rhizome, angelica root, prepared arisaema rhizome, sophora root, scutellaria root, and licorice root, grind and sift to make medicinal powder; The sulfur and cinnabar are mixed, ground, and sieved to make a fine powder. The borneol is ground and sieved to obtain borneol powder; S2. Add the medicinal powder to water, soak, decoct to obtain a decoction, and concentrate to obtain a thick paste; S3. Melt the petroleum jelly and add it to the thick paste. Stir, then add the fine powder and borneol powder in sequence and continue stirring to obtain the acne-clearing and acne-reducing ointment for treating acne.

6. The method for preparing an acne-clearing and acne-reducing ointment according to claim 5, characterized in that, The powder described in S1 has a mesh size of 100-150; the fine powder has a mesh size of 100-150; and the borneol powder has a mesh size of 80-100.

7. The method for preparing an acne-clearing and acne-reducing ointment according to claim 5, characterized in that, The mass-to-volume ratio of the powder to water in S2 is 1g:8-10mL; The soaking time is 30-60 minutes; The decocting temperature is 90-95℃, and the decocting time is 1-1.5h.

8. The method for preparing an acne-clearing and acne-reducing ointment according to claim 5, characterized in that, The concentration temperature described in S2 is 60-70℃, the concentration vacuum degree is -0.06MPa~-0.04MPa, and the concentration time is 1.5-2.5h.

9. The method for preparing an acne-clearing and acne-reducing ointment according to claim 5, characterized in that, The mass ratio of petrolatum to thick paste described in S3 is 1.5-2:1; The melting temperature is 75-85℃, and the melting holding time is 20-30 minutes. The stirring temperature is 50-60℃, the stirring speed is 150-250 r / min, and the stirring time is 30-40 min.

10. The use of the acne-clearing and acne-reducing ointment according to any one of claims 1-4 in the preparation of acne prevention or treatment drugs.

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