A method of synthesizing dihydropyrano[2,3-c]pyrazole analogs

By using a rhodium catalyst and a bisphosphine ligand for the enyne reaction, the problems of harsh conditions and byproduct generation in traditional synthetic methods have been solved, and the synthesis of highly selective and efficient dihydropyran[2,3-c]pyrazole analogues has been achieved, which has potential applications in medicinal chemistry.

CN122145477APending Publication Date: 2026-06-05DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
Filing Date
2024-12-03
Publication Date
2026-06-05

Smart Images

  • Figure BDA0005167357990000011
    Figure BDA0005167357990000011
  • Figure BDA0005167357990000021
    Figure BDA0005167357990000021
  • Figure BDA0005167357990000031
    Figure BDA0005167357990000031
Patent Text Reader

Abstract

The application relates to a method for synthesizing dihydropyrrolo[2,3-c]pyrazole analogs. Specifically, under the catalysis of a transition metal and a bidentate ligand, dihydropyrrolo[2,3-c]pyrazole analogs can be obtained in high selectivity by using the bidentate ligand synergy, taking pyrazolinone as raw material and reacting with 1,3-alkyne under the action of triethylenediamine. The application uses cheap and commercially available 1,3-alkyne and easily obtained pyrazolinone, and a series of heterocyclic compounds with potential medicinal value are obtained in high selectivity under simple and mild conditions.
Need to check novelty before this filing date? Find Prior Art