Preparation method for forming small molecule peptide based on mould synergistic degradation of egg shell membrane and small molecule peptide

By using a synergistic degradation system of Trichoderma reesei and Aspergillus niger, combined with membrane separation technology and low-temperature spray drying process, eggshell membranes were successfully converted into high-value small molecule peptides, solving the environmental problem of eggshell membrane treatment and creating economic value.

CN122146825APending Publication Date: 2026-06-05四川牧舟科技有限公司 +1
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Patent Information

Application Number
CN202610284944.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-10
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing technologies are insufficient to efficiently and cost-effectively convert eggshell membranes into small molecule peptides, and traditional methods may damage biological activity or cause environmental pollution.

Method used

By employing a synergistic degradation system of Trichoderma reesei and Aspergillus niger, combined with membrane separation technology and low-temperature spray drying process, and through optimization of specific parameters, we achieved efficient conversion of eggshell membranes and preparation of small molecule peptides.

Benefits of technology

This method achieves efficient conversion of eggshell membranes, producing small molecule peptides with concentrated molecular weight and good bioactivity, reducing production costs and environmental pollution, and has significant economic value.

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Abstract

The invention discloses a preparation method for forming a small molecule peptide based on mould synergistic degradation of an egg shell membrane and the small molecule peptide, and relates to the field of small molecule peptide preparation. Comprising the following steps: mixing a pretreated egg shell membrane with a mold fermentation liquid, and carrying out synergistic degradation; inactivating and centrifuging the degraded mixture, and collecting supernate; purifying the small molecule peptide in the supernate through a membrane separation technology; drying the purified small molecule peptide solution by adopting a low-temperature spray drying method to obtain small molecule peptide powder; the mould comprises trichoderma reesei and aspergillus niger. According to the method disclosed by the invention, through the synergistic degradation effect of the two moulds, the conversion of the egg shell membrane is more thorough, the yield of the small molecule peptide is obviously improved, the total nitrogen recovery rate can reach 85.2%, and the molecular weight distribution of the product is concentrated.
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