A device for thoroughly mixing raw materials for pharmaceutical production

Abstract

This invention discloses a device for thoroughly mixing raw materials for pharmaceutical production, relating to the technical field of pharmaceutical production equipment. It includes a base box, on which a first driving assembly is mounted. A carrying hopper is fixedly installed on the first driving assembly. Hydraulic cylinders are fixedly installed on the base box and on both sides of the carrying hopper. A housing is fixedly installed on each hydraulic cylinder. Shafts are rotatably mounted on the side walls of the housing. A mixing cylinder is fixedly installed between the shafts. A second driving assembly is located between the housing and the shafts. This invention, through a unique structural design, organically combines container tilting with internal stirring and is equipped with automatic wall scraping and material transfer functions. It effectively overcomes the defects of traditional mixing equipment, such as uneven mixing, dead corners, material residue, and low automation, significantly improving the efficiency, quality, and automation level of pharmaceutical raw material mixing. It has good practical value and application prospects.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical production equipment technology, specifically to a device for fully mixing raw materials used in pharmaceutical production. Background Technology

[0002] In pharmaceutical manufacturing, thorough and uniform mixing of raw materials is one of the key processes to ensure the consistency, stability, and final product quality of the drug components. The uniformity of raw material mixing directly affects the smooth progress of subsequent formulation processes and the stable efficacy of the finished drug, especially in the production of solid dosage forms (such as tablets, capsules, and granules), where the mixing process is of particular importance.

[0003] Currently, commonly used mixing equipment in the pharmaceutical industry mainly includes two-dimensional mixers, three-dimensional mixers, V-type mixers, and trough-type stirred mixers. While these devices can achieve material mixing to a certain extent, they still have several shortcomings: For example, some devices mainly rely on container rotation to achieve overall tumbling, resulting in weak internal shearing of the material. This is especially true for raw materials with large density differences, wide particle size distribution, or easy agglomeration, making it difficult to achieve ideal microscopic mixing uniformity. Some devices use fixed container internal stirring, which enhances local shearing but results in insufficient overall fluidity, easily creating mixing dead zones. Furthermore, material residues are easily left on the inner wall of the container after discharge, causing yield losses and potentially leading to cross-contamination between different batches. In addition, the feeding, mixing, and discharging processes of traditional equipment are often separated, with low levels of automation, requiring significant manual intervention, cumbersome operation, and limited production efficiency. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a device for fully mixing raw materials in pharmaceutical production, which solves the technical problems of traditional equipment where the feeding, mixing, and discharging processes are often separated, the degree of automation is low, there is a lot of manual intervention, the operation is cumbersome, and the production efficiency is limited.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a device for fully mixing raw materials for pharmaceutical production, comprising a base box, a first driving assembly on the base box, a carrying hopper fixedly mounted on the first driving assembly, hydraulic cylinders fixedly mounted on the base box and on both sides of the carrying hopper, a housing fixedly mounted on the hydraulic cylinders, a shaft cylinder rotatably mounted on the side wall of the housing, a mixing cylinder fixedly mounted between the shaft cylinders, a second driving assembly between the housing and the shaft cylinders, a stirring rod rotatably mounted on the upper inner wall of the mixing cylinder, a discharge pipe fixedly mounted on the lower inner wall of the mixing cylinder, and a linkage assembly between the stirring rod and the second driving assembly.

[0006] Preferably, the first drive assembly includes a first motor, which is fixedly installed on the outer rear wall of the base box. The drive end of the first motor passes through the rear wall of the base box and is fixedly installed with a lead screw. The other end of the lead screw is rotatably installed on the inner front wall of the base box. Guide rods are fixedly installed between the front and rear walls of the base box and on both sides of the lead screw. An opening is provided on the upper wall of the base box. An I-shaped block is slidably installed in the opening. A threaded hole is provided on the I-shaped block. Through holes are provided on both sides of the threaded hole on the I-shaped block. The I-shaped block is slidably installed on the guide rod through the through holes. The I-shaped block is engaged with the lead screw through the threaded hole. The bearing bucket is fixedly installed on the upper wall of the I-shaped block.

[0007] Preferably, rollers are installed at the four corners of the lower wall of the I-shaped block.

[0008] Preferably, the second drive assembly includes a second motor, a shaft is fixedly mounted on the drive end of the second motor, the other end of the shaft is rotatably mounted on the inner wall of the housing, a first drive gear is fixedly mounted on the shaft, and a first driven gear is fixedly mounted on the end of the shaft away from the mixing cylinder inside the housing, and the first drive gear and the first driven gear are meshed together.

[0009] Preferably, the linkage assembly includes an L-shaped box body, which is fixedly mounted on the mixing drum. The vertical end of the L-shaped box body communicates with the shaft cylinder. The upper end of the stirring rod passes through the mixing drum and the horizontal end of the L-shaped box body. A first transmission gear is fixedly mounted on the shaft rod and located on one side of the first driving gear. A first transmission shaft is rotatably mounted on the shaft cylinder. A second transmission gear is fixedly mounted on one end of the first transmission shaft, and the first transmission gear meshes with the second transmission gear. A third transmission gear is fixedly mounted on the other end of the first transmission shaft, and a second transmission shaft is rotatably mounted on the shaft cylinder. The second drive shaft has a fourth drive gear fixedly installed at one end inside the shaft sleeve. The fourth drive gear meshes with the third drive gear. The other end of the second drive shaft is located inside the L-shaped box and has a fifth drive gear fixedly installed thereon. The third drive shaft is rotatably installed inside the L-shaped box. A sixth drive gear is fixedly installed on the third drive shaft and meshes with the fifth drive gear. A second driven gear is fixedly installed at the upper end of the stirring rod. A second driving gear is fixedly installed on the third drive shaft and meshes with the second driven gear.

[0010] Preferably, the third transmission gear, the fourth transmission gear, the fifth transmission gear, the sixth transmission gear, the second driven gear, and the second driving gear are all bevel gear structures.

[0011] Preferably, a scraper is fixedly installed on the stirring rod, and the scraper is in contact with the inner wall of the mixing cylinder.

[0012] Preferably, a solenoid valve is fixedly installed on the discharge pipe.

[0013] Beneficial effects This invention provides a device for thoroughly mixing raw materials in pharmaceutical production, solving the technical problems of traditional equipment where the feeding, mixing, and discharging processes are often separated, automation is low, manual intervention is frequent, operation is cumbersome, and production efficiency is limited. This invention uses a second drive component to continuously rotate the mixing drum around a horizontal axis, causing the material to flow and scatter as a whole within the drum. Simultaneously, a linkage component transmits power to the stirring rod, causing it to rotate continuously within the mixing drum, applying shearing and stirring effects to the material. This combined "rotation + stirring" motion mode combines the advantages of overall convection and local shearing, effectively breaking up material agglomeration and reducing density segregation. It is particularly suitable for raw materials with large density differences, wide particle size distribution, or easy adhesion, significantly improving mixing uniformity and efficiency, and shortening mixing time.

[0014] The scraper on the stirring rod remains in constant contact with the inner wall of the mixing drum as the stirring rod rotates, effectively removing material adhering to the inner wall. This design not only improves the yield of a single batch of material and reduces losses, but also facilitates post-mixing cleaning, reduces the risk of cross-contamination between different batches of raw materials, and better complies with GMP requirements for pharmaceutical production.

[0015] The device integrates automatic feeding, mixing, discharging, and material transfer functions. The height and angle of the mixing drum can be adjusted via hydraulic cylinders for easy feeding and discharging; a solenoid valve on the discharge pipe enables automatic control of the discharge; and most importantly, the first drive assembly (screw drive) automatically moves the carrying hopper, allowing it to accurately receive material below the discharge port and move away from the workstation after being full, thus achieving automated connection between the mixing and discharging processes. This significantly reduces manual intervention, improves production efficiency, and reduces the labor intensity of operators.

[0016] Both the second drive assembly and the linkage assembly employ gear transmission, particularly using bevel gears in multiple locations. This ensures reliable power transmission and speed variation in orthogonal directions, guaranteeing stable and synchronized drive of the stirring rod while the mixing drum rotates. The entire transmission system is compact, rationally laid out, operates smoothly, has low noise, and is easy to maintain.

[0017] The mixing drum's tilt angle is adjustable, allowing for the selection of a suitable mixing posture based on material characteristics and process requirements; the stirring speed can also be adjusted via motor control. This enables the device to adapt to the mixing process needs of raw materials with different properties, making it highly versatile.

[0018] This invention, through its unique structural design, organically combines container tilting with internal stirring and is equipped with automatic wall scraping and material transfer functions. It effectively overcomes the defects of traditional mixing equipment, such as uneven mixing, dead corners, material residue, and low automation, and significantly improves the efficiency, quality, and automation level of pharmaceutical raw material mixing. It has good practical value and application prospects. Attached Figure Description

[0019] Figure 1 This is a front view schematic diagram of a pharmaceutical raw material mixing device according to the present invention.

[0020] Figure 2 This is a rear view schematic diagram of a pharmaceutical raw material mixing device according to the present invention.

[0021] Figure 3 This is a top view schematic diagram of a pharmaceutical raw material mixing device according to the present invention.

[0022] Figure 4 This is a cross-sectional structural schematic diagram of a pharmaceutical raw material mixing device according to the present invention.

[0023] Figure 5 This is a side view of the mixing cylinder of a pharmaceutical raw material mixing device according to the present invention.

[0024] Figure 6 This is a schematic diagram of the exploded structure of the mixing cylinder of a pharmaceutical raw material mixing device according to the present invention. Figure 7 This is a cross-sectional view of the base box of the pharmaceutical raw material mixing device described in this invention. Figure 8 This is an exploded view of the base box structure of the pharmaceutical raw material mixing device described in this invention. In the diagram: 1. Base box; 2. Loading hopper; 3. Hydraulic cylinder; 4. Box body; 5. Shaft cylinder; 6. Mixing cylinder; 7. Stirring rod; 8. Discharge pipe; 9. First motor; 10. Lead screw; 11. Guide rod; 12. I-shaped block; 13. Roller; 14. Second motor; 15. Shaft; 16. First driving gear; 17. First driven gear; 18. L-shaped box body; 19. First transmission gear; 20. First transmission shaft; 21. Second transmission gear; 22. Third transmission gear; 23. Second transmission shaft; 24. Fourth transmission gear; 25. Fifth transmission gear; 26. Third transmission shaft; 27. Sixth transmission gear; 28. Second driven gear; 29. ​​Second driving gear; 30. Scraper; 31. Solenoid valve. Detailed Implementation

[0025] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0026] This invention provides a technical solution: Please see Figures 1 to 8 The present invention provides a device for fully mixing raw materials for pharmaceutical production, comprising a base box 1, a first drive assembly, a bearing hopper 2, a hydraulic cylinder 3, a housing 4, a shaft cylinder 5, a mixing cylinder 6, a second drive assembly, a stirring rod 7, a discharge pipe 8, and a linkage assembly, among other main components.

[0027] Base box and first drive assembly The base box 1 is a rectangular box structure welded from steel plates. It is hollow inside and is used to house and support some of the transmission components of the first drive assembly. The bottom of the box can be equipped with shock-absorbing pads or anchor bolts to adapt to different ground installation requirements.

[0028] The first drive assembly includes a first motor 9, a lead screw 10, a guide rod 11, an I-beam block 12, and a roller 13. The first motor 9 is preferably a servo motor or a stepper motor, possessing precise speed and position control capabilities, and is fixedly mounted on the outer rear wall of the base box 1 via a motor mount. Its drive end is connected to one end of the lead screw 10 via a coupling, and the other end of the lead screw 10 is rotatably mounted on the inner front wall of the base box 1 via a bearing seat. The lead screw 10 is a precision ball screw to achieve high-precision, low-friction linear transmission.

[0029] Two guide rods 11 are arranged parallel to each other on both sides of the lead screw 10 and are fixed between the front and rear walls of the base box 1 by a bracket, serving as guides and supports to ensure the smooth movement of the I-shaped block 12. The surface of the guide rods 11 can be hardened and polished, or fitted with linear bearings to further reduce friction.

[0030] The I-shaped block 12 is an inverted "I"-shaped slider, with its upper part passing through a long strip opening on the upper wall of the base box 1, and its lower part located inside the box. It has threaded holes that engage with the lead screw 10, and through holes on both sides to fit onto the guide rod 11. Four rollers 13 are installed at the four corners of the lower wall of the I-shaped block 12. The rollers can be made of nylon or rubber-coated material, rolling on the inner bottom plate of the base box 1, significantly reducing movement resistance and improving transmission efficiency and lifespan.

[0031] The carrying hopper 2 is an open-top container, which can be made of stainless steel and is fixedly installed on the upper wall of the I-shaped block 12 to receive the mixed materials. Its volume can be designed according to the batch capacity of the mixing cylinder 6, and an observation window or material level sensor can be installed on the side wall.

[0032] Lifting and Support Structure Two hydraulic cylinders 3 are symmetrically fixedly installed on the upper surface of the base box 1 and on both sides of the carrying hopper 2. The upper end of the piston rod of the hydraulic cylinder 3 is connected to the box body 4 through a flange. The hydraulic cylinders 3 are driven by an external hydraulic station and can be raised and lowered synchronously, thereby driving the entire box body 4 and the mixing cylinder 6 to move vertically to adapt to different height and inclination requirements during feeding, mixing, and discharging. The hydraulic system can integrate control valves and position sensors to achieve precise stroke control.

[0033] Hybrid main structure The housing 4 is a rigid frame structure, housing the second drive assembly and some linkage components. Two coaxial shafts 5 are rotatably mounted on its two side walls via bearing seats. The shafts 5 are hollow tubular structures, with one end extending into the housing 4 and the other end fixedly connected to the mixing cylinder 6. The mixing cylinder 6 is a cylindrical container closed at both ends, its axis coinciding with the axis of the shafts 5, and can rotate with the shafts 5. The mixing cylinder 6 is preferably made of 316L stainless steel, with its inner wall polished or electrolytically polished to achieve a mirror finish with Ra≤0.4μm to reduce material adhesion. A feed inlet with a sealing cap (not shown in the figure) can be provided at the top of the mixing cylinder 6, and a discharge pipe 8 is welded to the center of the bottom. A solenoid valve 31 is installed on the discharge pipe 8 to control the opening and closing of the discharge inlet.

[0034] Second drive component The second drive assembly is used to drive the mixing drum 6 to rotate. It includes a second motor 14, a shaft 15, a first driving gear 16, and a first driven gear 17. The second motor 14 is fixed to the outer wall of the housing 4, and is preferably a variable frequency speed-regulating motor, allowing for stepless speed adjustment. The shaft 15 is rotatably supported on the inner wall of the housing 4 by two bearings. The first driving gear 16 and the first driven gear 17 are a pair of cylindrical gears, with their module and number of teeth designed according to the required torque and speed. The first driven gear 17 is fixedly sleeved on the end of the shaft cylinder 5 that extends into the housing 4. When the second motor 14 starts, it drives the first driving gear 16 to rotate via the shaft 15, thereby driving the first driven gear 17, shaft cylinder 5, and mixing drum 6 to continuously rotate around the horizontal axis.

[0035] Linkage components and stirring system The linkage component is used to transmit the power branch of the second drive component to the stirring rod 7, realizing the synchronous operation of the mixing drum rotation and internal stirring. Its core lies in a spatial transmission chain composed of a series of gears and drive shafts.

[0036] The linkage assembly includes an L-shaped box 18, a first drive shaft 20, a second drive shaft 23, a third drive shaft 26, and multiple sets of gears. The L-shaped box 18 is welded and fixed to the outer wall of the mixing cylinder 6, with its vertical lower end communicating with the inner cavity of the shaft cylinder 5, and its horizontal end located above the top of the mixing cylinder 6.

[0037] The stirring rod 7 is rotatably mounted on the center of the upper wall of the mixing cylinder 6 via two bearings. Its lower end extends into the inner cavity of the mixing cylinder 6, and its upper end passes through the upper wall of the mixing cylinder 6 and the horizontal end of the L-shaped box 18. Multiple layers of blades (not shown in detail in the figure) can be installed on the lower part of the stirring rod 7, and the blade angle can be designed as either a propulsion type or a shearing type. A second driven gear 28 is fixed to the upper end of the stirring rod 7.

[0038] The detailed transmission path is as follows: The second motor 14 drives the shaft 15 to rotate. In addition to the first driving gear 16, the shaft 15 also has a first transmission gear 19 fixed on it. The first transmission shaft 20 is rotatably mounted on the outer wall of the shaft cylinder 5 via bearings. One end of the shaft is fixed with the second transmission gear 21, which meshes with the first transmission gear 19; the other end extends into the inner cavity of the shaft cylinder 5 and is fixed with the third transmission gear 22. The second transmission shaft 23 is rotatably mounted inside the shaft cylinder 5 via bearings, coaxial with the shaft cylinder 5 but rotatable relative to it. One end of the shaft is fixed with the fourth transmission gear 24, which meshes with the third transmission gear 22; the other end passes through the shaft cylinder 5 and extends into the vertical part of the L-shaped box 18, and is fixed with the fifth transmission gear 25. The third transmission shaft 26 is rotatably mounted inside the L-shaped box 18 via bearings, in a horizontal direction. One end of the third transmission shaft 26 is fixed with the sixth transmission gear 27, which meshes with the fifth transmission gear 25; the other end is fixed with the second driving gear 29, which meshes with the second driven gear 28 at the upper end of the stirring rod 7.

[0039] The key improvement lies in the fact that the third transmission gear 22 and the fourth transmission gear 24, the fifth transmission gear 25 and the sixth transmission gear 27, and the second driving gear 29 and the second driven gear 28 are all bevel gears (bevel gears). Bevel gears can change the direction of power transmission by 90 degrees, which is very suitable for the scenario in this invention where axial rotational power needs to be converted into radial rotational power, and the transmission is smooth and the load-bearing capacity is high.

[0040] Wall scraping device At least one scraper 30 is fixedly installed on the portion of the stirring rod 7 located inside the mixing cylinder 6. The scraper 30 is typically made of a flexible material (such as food-grade polyurethane or silicone rubber) or a rigid material covered with a flexible liner. Its outer edge profile matches the curved surface of the inner wall of the mixing cylinder 6 and maintains slight contact pressure. As the stirring rod 7 rotates, the scraper 30 rotates accordingly, continuously scraping the inner wall of the mixing cylinder 6 to prevent material adhesion or scaling.

[0041] The control system can be equipped with a PLC (Programmable Logic Controller) or an industrial computer control system. The control system integrates the linkage control of the first motor 9, the second motor 14, the hydraulic cylinder 3, and the solenoid valves 31. It can achieve the following automated process: After startup, the hydraulic cylinder 3 raises the mixing drum to the feeding position, opening the feeding port (or feeding under negative pressure through the discharge pipe); after feeding is completed, the hydraulic cylinder 3 adjusts to the horizontal mixing position, the second motor 14 starts, the mixing drum 6 rotates at a set speed, and simultaneously the stirring rod 7 rotates at a set speed for timed mixing; after mixing is completed, the second motor 14 stops, and the hydraulic cylinder 3 moves the mixing drum 6 to the vertical discharge position (discharge pipe 8 facing downwards); the solenoid valve 31 opens, and the material is discharged into the lower carrying hopper 2; after the material is discharged, the first motor 9 starts, driving the carrying hopper 2 to move along the screw 10 to the designated receiving or transfer position; the entire process can be operated unattended.

[0042] Detailed Workflow The following describes a complete working cycle of this device in detail with reference to the accompanying drawings: Step 1: Material Preparation Initial state: The supporting hopper 2 is located at the rear of the base box 1 (away from the discharge pipe 8). The mixing cylinder 6 is in a vertical position, and the port of the discharge pipe 8 is facing upward (at this time it can be used as a feed inlet), and the solenoid valve 31 is closed.

[0043] Start hydraulic cylinder 3 to lift box 4 and mixing cylinder 6 to a suitable height, making it easy for operators or automatic feeders to connect.

[0044] The raw materials to be mixed are fed into the mixing cylinder 6 through the discharge pipe 8 (which serves as the feed inlet) or a dedicated feed port at the top of the mixing cylinder 6. The raw materials can be a mixture of various powders and granules.

[0045] Step 2: Mixing process After feeding is completed, hydraulic cylinder 3 is activated to adjust mixing cylinder 6 to a roughly horizontal position (usually the angle between the axis and the horizontal plane is 0-30 degrees, which can be adjusted according to the process).

[0046] The second motor 14 is started. The second motor 14 drives the first drive gear 16 to rotate via the shaft 15. The first drive gear 16 drives the first driven gear 17, which in turn drives the two shaft cylinders 5 to rotate synchronously. The shaft cylinders 5 drive the mixing cylinder 6 to rotate continuously and uniformly around its horizontal axis (e.g., at a speed range of 5-30 rpm).

[0047] Synchronized stirring action: As the shaft 15 rotates, the first transmission gear 19 rotates accordingly. Power is transmitted sequentially through the second transmission gear 21 → first transmission shaft 20 → third transmission gear 22 → fourth transmission gear 24 → second transmission shaft 23 → fifth transmission gear 25 → sixth transmission gear 27 → third transmission shaft 26 → second driving gear 29 → second driven gear 28, ultimately driving the stirring rod 7 to rotate at high speed relative to the mixing cylinder 6 (e.g., speed range 50-300 rpm).

[0048] Composite mixing effect: Under the tumbling action of the mixing drum 6, the material is continuously lifted and scattered within the drum, achieving macroscopic convective mixing. Simultaneously, the high-speed rotating stirring rod 7 generates strong shearing, diffusion, and localized disturbances on the material, achieving microscopic dispersion mixing. The scraper 30 continuously cleans the drum wall, ensuring all material participates in circulation without any stagnant dead zones.

[0049] The mixing time is preset by the control system. During this period, the tumbling speed and stirring speed can be adjusted according to the material characteristics (such as particle size, density, and viscosity) to achieve the best mixing effect.

[0050] Step 3: Discharge and Transfer When the mixing time is up, the second motor 14 stops running. The control system controls the hydraulic cylinder 3 to adjust the mixing drum 6 to a completely vertical position, with the discharge pipe 8 port precisely pointing downwards and aligned with the bearing hopper 2 at its initial position below.

[0051] Open the solenoid valve 31 on the discharge pipe 8. Under the action of gravity, the uniformly mixed material is smoothly discharged through the discharge pipe 8. Due to the action of the scraper 30, there is almost no residue on the inner wall of the cylinder, the discharge is complete, and the yield is high.

[0052] After all the material has fallen into the carrying hopper 2, the solenoid valve 31 closes.

[0053] Start the first motor 9 (forward rotation). The first motor 9 drives the lead screw 10 to rotate. Since the I-shaped block 12 engages with the lead screw 10 through the threaded hole and is restricted to linear movement by the guide rod 11, the rotation of the lead screw 10 is converted into the I-shaped block 12 (along with the bearing bucket 2) moving forward along the guide rod 11 (towards) Figure 1 The movement is a smooth linear motion on the right side (the side furthest from the second motor 14). Rollers 13 assist in the movement and reduce friction.

[0054] The carrying hopper 2 is transported to a designated receiving station at the front end (e.g., docking with a downstream packaging machine hopper or transfer container). Once in place, the first motor 9 stops. The material in the carrying hopper 2 can be removed manually or by a robotic arm, or the carrying hopper 2 can be designed for tipping and unloading.

[0055] After unloading, the first motor 9 reverses and drives the carrying bucket 2 back to its initial position (directly below the discharge pipe) along the original path, ready to receive the next batch of material.

[0056] Step 4: Cleaning Preparation After one batch is completed, the cleaning process can begin. Cleaning solvent is injected through the inlet or outlet pipe, and the mixing drum is restarted for tumbling and stirring (at low speed). The scraping action of the scraper 30 and the flushing action of the liquid quickly clean the inner wall of the mixing drum 6 and the stirring components. Cleaning waste liquid can be discharged through the outlet pipe 8. This design greatly simplifies the cleaning process.

[0057] Scraper variant: Scraper 30 can be spring-loaded to keep it in close contact with the cylinder wall, ensuring scraping effect even if the cylinder wall is slightly deformed or worn.

[0058] Drive variants: The first drive assembly can use a synchronous belt, chain, or linear motor instead of a lead screw drive. The second drive assembly can use a direct drive motor (torque motor) to directly drive the shaft cylinder 5, simplifying the gear structure.

[0059] Mixing cylinder variant: A fixed baffle or guide vane can be added inside the mixing cylinder 6 to enhance the turbulence effect of the material during tumbling.

[0060] Materials and Sealing: All parts that come into contact with materials (mixing cylinder 6, stirring rod 7, scraper 30, discharge pipe 8, and bearing hopper 2) are made of stainless steel that meets GMP requirements, and the seals are made of food-grade silicone or PTFE to ensure no contamination and easy cleaning.

[0061] Protection and Safety: The device can be equipped with safety features such as a transparent protective cover, an emergency stop button, and operating status indicator lights. Transmission components are fitted with protective housings to prevent human contact.

[0062] Working principle: As shown in the accompanying drawings, during use, the outlet pipe 8 is initially positioned with its port facing upwards. Material is then introduced into the mixing drum 6 through the outlet pipe 8. At this point, the solenoid valve 31 is closed, and simultaneously, the second motor 14 is started. The drive end of the second motor 14 rotates the shaft 15, which in turn rotates the first drive gear 16. The first drive gear 16 meshes with the first driven gear 17, causing the first driven gear 17 to rotate the shaft cylinder 5. This, in turn, causes the shaft cylinder 5 to rotate, thus causing the mixing drum 6 to tumble and mix the material within. Simultaneously, the shaft 15 rotates the first transmission gear 19, which in turn rotates the second transmission gear 21. The second transmission gear 21 rotates the first transmission shaft 20, which in turn rotates the third transmission gear 22. The third transmission gear 22 rotates the fourth transmission gear 24, which in turn rotates the second transmission shaft 23. The second transmission shaft 23 rotates the fifth transmission gear 25, which in turn rotates the sixth transmission gear 27. The sixth transmission gear 27 drives the third transmission shaft 26 to rotate, which in turn drives the second driving gear 29 to rotate. The second driving gear 29 then drives the second driven gear 28 to rotate, which in turn drives the stirring rod 7 to rotate. This causes the material inside the mixing drum 6 to be both agitated and mixed. The scraper 30 cleans the material inside the mixing drum 6 to prevent it from sticking to the walls. After the material in the mixing drum 6 is fully mixed, the mixing drum 6 is positioned vertically, and the outlet pipe 8 is opened... With the material facing downwards, the solenoid valve 31 is opened, and the material in the mixing cylinder 6 falls into the carrying hopper 2. After the material in the mixing cylinder 6 is completely discharged, the first motor 9 is started. The drive end of the first motor 9 drives the lead screw 10 to rotate. Since the I-shaped block 12 is connected to the lead screw 10 through the threaded hole, the lead screw 10 has a driving tendency to drive the I-shaped block 12 when it rotates. At this time, the I-shaped block 12 moves along the path of the guide rod 11, and the roller 13 assists the I-shaped block 12 in moving, thereby moving the carrying hopper 2 to the side of the discharge pipe 8, which facilitates the material discharge.

[0063] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

Claims

1. A raw material mixing device for pharmaceutical production, comprising a base box (1), characterized in that, The base box (1) is provided with a first drive assembly, and a bearing bucket (2) is fixedly installed on the first drive assembly. Hydraulic cylinders (3) are fixedly installed on the base box (1) and on both sides of the bearing bucket (2). A box body (4) is fixedly installed on the hydraulic cylinders (3). A shaft cylinder (5) is rotatably installed on the side wall of the box body (4). A mixing cylinder (6) is fixedly installed between the shaft cylinders (5). A second drive assembly is provided between the box body (4) and the shaft cylinders (5). A stirring rod (7) is rotatably installed on the upper wall of the mixing cylinder (6). A discharge pipe (8) is fixedly installed on the lower wall of the mixing cylinder (6). A linkage assembly is provided between the stirring rod (7) and the second drive assembly.

2. The apparatus for thoroughly mixing raw materials for pharmaceutical production according to claim 1, characterized in that... The first drive assembly includes a first motor (9), which is fixedly installed on the outer rear wall of the base box (1). The drive end of the first motor (9) passes through the rear wall of the base box (1) and is fixedly installed with a lead screw (10). The other end of the lead screw (10) is rotatably installed on the inner front wall of the base box (1). Guide rods (11) are fixedly installed between the inner front and rear walls of the base box (1) and on both sides of the lead screw (10). An opening is provided on the upper wall of the base box (1). An I-shaped block (12) is slidably installed in the opening. A threaded hole is provided on the I-shaped block (12). Through holes are provided on both sides of the threaded hole on the I-shaped block (12). The I-shaped block (12) is slidably installed on the guide rod (11) through the through hole. The I-shaped block (12) is engaged with the lead screw (10) through the threaded hole. The bearing bucket (2) is fixedly installed on the upper wall of the I-shaped block (12).

3. The apparatus for thoroughly mixing raw materials for pharmaceutical production according to claim 2, characterized in that... Rollers (13) are installed at the four corners of the lower wall of the I-shaped block (12).

4. The apparatus for thoroughly mixing raw materials for pharmaceutical production according to claim 1, characterized in that... The second drive assembly includes a second motor (14), a shaft (15) is fixedly mounted on the drive end of the second motor (14), the other end of the shaft (15) is rotatably mounted on the inner wall of the housing (4), a first drive gear (16) is fixedly mounted on the shaft (15), and a first driven gear (17) is fixedly mounted on the end of the shaft cylinder (5) away from the mixing cylinder (6) inside the housing (4), and the first drive gear (16) and the first driven gear (17) are meshed and connected.

5. The apparatus for thoroughly mixing raw materials for pharmaceutical production according to claim 4, characterized in that... The linkage assembly includes an L-shaped box (18) which is fixedly mounted on a mixing cylinder (6). The vertical end of the L-shaped box (18) is connected to the shaft cylinder (5). The upper end of the stirring rod (7) passes through the mixing cylinder (6) and the horizontal end of the L-shaped box (18). A first transmission gear (19) is fixedly mounted on the shaft (15) and located on one side of the first driving gear (16). A first transmission shaft (20) is rotatably mounted on the shaft cylinder (5). A second transmission gear (21) is fixedly mounted on one end of the first transmission shaft (20). The first transmission gear (19) and the second transmission gear (21) are meshed and connected. A third transmission gear (22) is fixedly mounted on the other end of the first transmission shaft (20). A second transmission shaft (23) is rotatably mounted on the shaft cylinder (5). The second drive shaft (23) is fixedly mounted with a fourth drive gear (24) at one end inside the shaft sleeve (5). The fourth drive gear (24) meshes with the third drive gear (22). The other end of the second drive shaft (23) is located inside the L-shaped box (18) and is fixedly mounted with a fifth drive gear (25). The third drive shaft (26) is rotatably mounted inside the L-shaped box (18). The sixth drive gear (27) is fixedly mounted on the third drive shaft (26). The sixth drive gear (27) meshes with the fifth drive gear (25). The upper end of the stirring rod (7) is fixedly mounted with a second driven gear (28). The third drive shaft (26) is fixedly mounted with a second driving gear (29). The second driving gear (29) meshes with the second driven gear (28).

6. The apparatus for thoroughly mixing raw materials for pharmaceutical production according to claim 5, characterized in that... The third transmission gear (22), the fourth transmission gear (24), the fifth transmission gear (25), the sixth transmission gear (27), the second driven gear (28), and the second driving gear (29) are all bevel gear structures.

7. The apparatus for thoroughly mixing raw materials for pharmaceutical production according to claim 1, characterized in that... A scraper (30) is fixedly installed on the stirring rod (7), and the scraper (30) is in contact with the inner wall of the mixing cylinder (6).

8. The apparatus for thoroughly mixing raw materials for pharmaceutical production according to claim 1, characterized in that... A solenoid valve (31) is fixedly installed on the discharge pipe (8).

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