A reagent strip, capture wand, sample analyzer

Abstract

This application provides a reagent strip, a capture rod, and a sample analyzer. The reagent strip includes a reagent strip body and a capture rod. The reagent strip body includes a sample chamber, a reagent chamber, and a capture rod chamber. The sample chamber is used to contain a sample. The reagent chamber contains reagents for sample detection. The capture rod chamber is used to hold the capture rod. The capture rod includes an interconnected rod-shaped body and a closed structure. The rod-shaped body includes a first rod segment. One of the cavity wall of the capture rod chamber and the closed structure is provided with a positioning recess, and the other is provided with a positioning protrusion. The opening of the positioning recess faces or is away from the rod-shaped body, and the positioning recess and the positioning protrusion are engaged. The reagent strip of this application utilizes the capture rod's own structure to close the capture rod chamber and also utilizes the engagement of the positioning recess and the positioning protrusion to achieve the positioning of the capture rod. Thus, it is not necessary to configure an additional outer cover for the reagent strip body to position the capture rod, resulting in a simple structure and convenient operation.

Description

Technical Field

[0001] This application relates to the field of in vitro diagnostic technology, and in particular to a reagent strip, a capture rod, and a sample analyzer. Background Technology

[0002] In related technologies, the test strip is equipped with a capture rod, on which a coating layer is formed. The capture rod is placed and sealed within the cavity of the test strip, meaning it is an accessory of the test strip. The test strip has a flip-top structure. After the capture rod is placed into the cavity, a sealing gasket is placed at the opening of the cavity. When the flip-top is closed, it maintains the distance between the flip-top and the capture rod, forming a sealing fit to seal the capture rod within the cavity. This solution requires a flip-top structure to position the capture rod, and an additional opening mechanism is needed when opening the cap, making the structure relatively complex. Furthermore, the test strip requires an additional sealing gasket to ensure the orientation and sealing state of the capture rod relative to the test strip. Summary of the Invention

[0003] In view of this, embodiments of this application aim to provide a test strip, a capture rod, or a sample analyzer to solve at least one of the above-mentioned problems.

[0004] This application provides a reagent strip, comprising:

[0005] The reagent strip body has multiple chambers with a top-side opening, including a sample chamber, a reagent chamber, and a capture rod chamber; the sample chamber is used to contain a sample; the reagent chamber contains reagents for sample detection; and the capture rod chamber is used to place a capture rod.

[0006] A capture rod includes interconnected rod-shaped bodies and a closed structure, wherein the rod-shaped bodies include a first rod segment located on the bottom side of the closed structure; the closed structure is used to openably and close the cavity of the capture rod.

[0007] The cavity wall of the capture rod cavity and one of the closed structures are provided with a positioning recess, and the other is provided with a positioning protrusion. The opening of the positioning recess faces or is away from the rod-shaped body. The positioning recess and the positioning protrusion are fitted together to position the capture rod on the reagent strip body and to place the first rod segment in the capture rod cavity in a suspended position.

[0008] The reagent strip of this application embodiment uses the capture rod's own structure to close the capture rod cavity, and also uses the interlocking of the positioning recess and positioning protrusion to achieve the positioning of the capture rod. Thus, there is no need to configure an additional outer cover for the reagent strip body to position the capture rod, which is simple in structure and easy to operate.

[0009] In some implementations, the rod-shaped body and the closed structure are integrally formed.

[0010] In some implementations, the positioning recess and positioning protrusion are sealed together to achieve a seal between the closed structure and the cavity wall of the capture rod cavity.

[0011] In some embodiments, the reagent strip includes a sealing element, and the sealing structure and the cavity wall of the capture rod cavity are both sealed with the sealing element to achieve a seal between the sealing structure and the cavity wall of the capture rod cavity;

[0012] Preferably, the sealing element and the cavity wall of the capture rod cavity are integrally formed, or the sealing element and the sealing structure are integrally formed.

[0013] In some embodiments, the seal is located below or above the mating surface formed by the positioning recess and the positioning protrusion; preferably, the seal is located below the mating surface formed by the positioning recess and the positioning protrusion.

[0014] In some embodiments, the seal is located above the mating surface formed by the positioning recess and the positioning protrusion, the upper part of the sealing structure closes the opening of the capture rod cavity, and the lower part of the sealing structure and the cavity wall of the capture rod cavity are mated by the positioning recess and the positioning protrusion; or,

[0015] The sealing element is located below the mating surface formed by the positioning recess and the positioning protrusion. The sealing structure is used to close the opening of the capture rod cavity. It also provides the positioning recess or the positioning protrusion and is mated with the positioning recess or positioning protrusion provided on the cavity wall of the capture rod cavity.

[0016] In some embodiments, when the seal is fixedly connected to the closed structure, at least one of the seal and the cavity wall of the capture rod cavity at the sealing joint is provided with an inclined guide surface; or, when the seal is fixedly connected to the capture rod cavity, at least one of the seal and the closed structure at the sealing joint is provided with an inclined guide surface.

[0017] In some embodiments, the capture rod cavity includes a first cavity segment and a second cavity segment arranged along the extension direction of the closed structure toward the first rod segment, the cross-sectional area of ​​the first cavity segment being larger than the cross-sectional area of ​​the second cavity segment, the cavity walls of the first cavity segment and the cavity walls of the second cavity segment being connected by a stepped surface, at least a portion of the closed structure being accommodated in the first cavity segment, and at least a portion of the first rod segment being located in the second cavity segment.

[0018] In some embodiments, the bottom side of the closed structure has a sealing surface located above the stepped surface, and the reagent strip includes a seal disposed between the sealing surface and the stepped surface, sealing the gap between the sealing surface and the stepped surface.

[0019] In some embodiments, the upper part of the closed structure is located in the first cavity segment, the lower part of the closed structure is located in the second cavity segment, and the positioning recess or the positioning protrusion is provided and engages with the positioning recess or positioning protrusion provided on the cavity wall of the capture rod cavity.

[0020] In some embodiments, the positioning recess or the positioning protrusion is disposed on the cavity wall of the first cavity segment, and the sealing structure is entirely located in the first cavity segment when sealing the capture rod cavity;

[0021] Alternatively, the closed structure includes a first closed portion and a second closed portion arranged along the extension direction of the closed structure toward the first rod segment, the cross-sectional area of ​​the first closed portion being larger than the cross-sectional area of ​​the second closed portion, the first closed portion being located in the first cavity segment, and at least a portion of the second closed portion extending into the second cavity segment; one of the positioning recess and the positioning protrusion is disposed on the cavity wall of the second cavity segment, and the other is disposed on the second closed portion.

[0022] In some embodiments, the positioning protrusion includes a protruding ring or multiple positioning protrusions; and / or,

[0023] The positioning recess includes one or more grooves, or the reagent strip includes a first protruding structure and a second protruding structure, the first protruding structure and the second protruding structure being arranged at intervals along the extension direction of the rod-shaped body, and the interval between them defining the positioning recess.

[0024] In some embodiments, the positioning protrusion and the positioning recess have multiple spaced-apart engagement positions on the circumference of the rod-shaped body, the multiple engagement positions being centrally symmetrical and / or mirror-symmetrical with respect to the axis of the rod-shaped body; preferably,

[0025] The number of the interlocking positions is 2 to 6.

[0026] In some embodiments, the positioning protrusion includes a helical protrusion, and both the helical protrusion and the helical groove extend helically around the axis of the rod-shaped body, with the helical protrusion and the helical groove engaging helically.

[0027] In some embodiments, the first rod segment includes a first part and a second part, the first part being connected to one end of the second part near the closed structure, wherein the cross-sectional area of ​​the first part is smaller than the cross-sectional area of ​​the second part;

[0028] At least a portion of the surface of the first rod segment is covered with a coating layer;

[0029] The sample cavity is used to insert the first rod segment so that the coating layer can capture the target substance in the sample;

[0030] The reagent chamber is used to insert the first rod segment so that the target substance captured by the coating layer comes into contact with the reagent.

[0031] When the first rod segment is placed into the sample chamber or the reagent chamber, the liquid level in the sample chamber or the reagent chamber is within the height range of the first part; preferably, the first part includes a first sub-segment, a necking structure, and a second sub-segment in sequence along the extension direction of the closed structure toward the first rod segment, the necking structure connecting the first sub-segment and the second sub-segment, and the cross-sectional area of ​​the first sub-segment and the second sub-segment generally decreases from both ends of the first part toward the direction close to the necking structure.

[0032] In some embodiments, the rod-shaped body further includes a second rod segment connected to the top side of the closed structure, and the outer periphery of the second rod segment is provided with a gripping engagement structure for the retrieval mechanism to grip.

[0033] Preferably, the gripping engagement structure includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment; or, the gripping engagement structure includes one or more slots recessed into the outer peripheral surface of the second rod segment.

[0034] This application provides a trapping rod for reagent strips, the trapping rod comprising:

[0035] The rod-shaped main body includes the first rod segment;

[0036] A closed structure surrounds the outer periphery of the rod-shaped body and is connected to the rod-shaped body, with the first rod segment located on the first side of the closed structure.

[0037] The first rod segment includes a first part and a second part, the first part being connected between the second part and the closed structure, and the cross-sectional area of ​​the first part being smaller than that of the second part.

[0038] In some embodiments, the reagent strip further includes a capture rod cavity for placing the capture rod, and the outer peripheral surface of the closed structure is provided with a positioning recess or a positioning protrusion, the positioning recess or the positioning protrusion being used to fit into the cavity wall of the capture rod cavity so that the first rod segment of the capture rod is suspended in the capture rod cavity.

[0039] In some embodiments, the rod-shaped body includes a second rod segment connected to a second side of the closed structure, the first side and the second side being opposite to each other, and the outer periphery of the second rod segment is provided with a gripping engagement structure for the retrieval mechanism to grasp.

[0040] Preferably, the gripping engagement structure includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment; or, the gripping engagement structure includes one or more slots recessed into the outer peripheral surface of the second rod segment.

[0041] This application provides a sample analyzer, including:

[0042] Sample analysis module and reagent strips,

[0043] The reagent strip includes a capture rod and a reagent strip body. The reagent strip body has multiple chambers with a top-side opening. The multiple chambers include a sample chamber, a reagent chamber, and a capture rod chamber. The capture rod includes an interconnected rod-shaped body and a sealing structure. The sealing structure is detachably connected to the capture rod chamber and seals the capture rod chamber.

[0044] The sample analysis module includes:

[0045] A reagent strip storage area, wherein at least one of the reagent strips can be placed in the reagent strip storage area, and at least the top surface of the enclosed structure is exposed to the environment of the reagent strip storage area;

[0046] A sample dispensing mechanism, wherein the sample dispensing mechanism is used to dispense the sample into the sample cavity of the reagent strip;

[0047] A retrieving mechanism for driving the movement of the capture rod of the reagent strip;

[0048] A testing organization, which is used to test the test product prepared based on the sample;

[0049] The controller is used to control the retrieving mechanism to move to the position of the reagent strip, grasp the capture rod, remove the capture rod from the capture rod cavity, and control the detection mechanism to detect the product to be tested.

[0050] In some embodiments, the rod-shaped body includes a first rod segment and a second rod segment, the first rod segment and the second rod segment being located on opposite sides of the closed structure, and the first rod segment being suspended in the capture rod cavity;

[0051] The outer periphery of the second rod segment is provided with a gripping engagement structure for the retrieval mechanism to grasp;

[0052] The controller is used to control the retrieval mechanism to grasp the grasping engagement structure and move upward in a straight line to remove the capture rod from the capture rod cavity;

[0053] Preferably, the gripping engagement structure includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment; or, the gripping engagement structure is one or more slots recessed into the outer peripheral surface of the second rod segment.

[0054] In some embodiments, one of the cavity wall of the capture rod cavity and the closed structure is provided with a positioning recess, and the other is provided with a positioning protrusion. The opening of the positioning recess faces or is away from the rod-shaped body. The positioning recess and the positioning protrusion are fitted together to position the capture rod on the reagent strip body, and the part of the rod-shaped body located below the closed structure is suspended in the capture rod cavity.

[0055] The advantages of this embodiment are as follows: The capture rod cavity is sealed by its own structure, and the positioning of the capture rod is achieved through the interlocking of the positioning recess and the positioning protrusion. Thus, there is no need for an additional outer cover on the reagent strip body for positioning the capture rod, resulting in a simple structure and convenient operation. By providing mutually cooperating sealing elements and sealing surfaces on the capture rod or its cavity, a leak-proof seal can be achieved within the capture rod cavity. By incorporating a necking structure in the first section of the capture rod, it can better adapt to the reagent liquid level during reaction within the reagent strip, thereby reducing the change in coating reaction area caused by liquid level errors and lowering detection repeatability errors. By incorporating a gripping mating structure in the second section of the capture rod, the gripping action of the capture rod is simplified, improving detection efficiency. Attached Figure Description

[0056] Figure 1 This is a schematic diagram of the main body of a reagent strip according to an embodiment of this application;

[0057] Figure 2 This is a schematic diagram of the reagent strip according to the first embodiment of this application;

[0058] Figure 3 for Figure 2 A schematic diagram of the capture rod in the image;

[0059] Figure 4 for Figure 3 The capture rod shown is projected onto a plane perpendicular to the extension direction of the rod-shaped body.

[0060] Figure 5 This is a schematic diagram of the reagent strip according to the second embodiment of this application;

[0061] Figure 6 This is a schematic diagram of the reagent strip according to the third embodiment of this application;

[0062] Figure 7 for Figure 6 A schematic diagram of the main body of the reagent strip;

[0063] Figure 8 This is a schematic diagram of the reagent strip according to the fourth embodiment of this application;

[0064] Figure 9 This is a schematic diagram of the reagent strip according to the fifth embodiment of this application;

[0065] Figure 10 This is a schematic diagram of the reagent strip according to the sixth embodiment of this application;

[0066] Figure 11 for Figure 10 A schematic diagram of the capture rod in the image;

[0067] Figure 12 This is a schematic diagram of a retrieval mechanism grasping a capture rod according to an embodiment of this application.

[0068] Explanation of reference numerals in the attached figures

[0069] 100. Reagent strip; 11. Capture rod; 111. First rod segment; 1111. First part; 1112. Second part; 11111. First sub-segment; 11112. Necking structure; 11113. Second sub-segment; 112. Closed structure; 112A. First inclined guide surface; 1121. First closed part; 1122. Second closed part; 113. Second rod segment; 1131. Grasping and mating structure; 100A. Fixed 100B, Positioning protrusion; 100B1, First protruding structure; 100B2, Second protruding structure; 112, Reagent strip body; 12A, Capture rod cavity; 12A1, First cavity segment; 12A2, Second cavity segment; 121, Step surface; 122, Seal; 122A, Second inclined guide surface; 12B, Sample cavity; 12C, Reagent cavity; 12D, Photometric cavity; 200, Retrieval mechanism; 201, Claw. Detailed Implementation

[0070] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0071] The specific technical features described in the specific embodiments can be combined in any suitable manner without contradiction. For example, different combinations of specific technical features can form different embodiments and technical solutions. To avoid unnecessary repetition, the various possible combinations of the specific technical features in this invention will not be described separately.

[0072] In the following description, the terms "first," "second," etc., are used merely to distinguish different objects and do not indicate that the objects have the sameness or relationship. It should be understood that the directional descriptions "above," "below," "outside," and "inside" refer to the orientation under normal use conditions, while "left" and "right" refer to the left and right directions shown in the corresponding diagrams, which may or may not be the left and right directions under normal use conditions.

[0073] It should be noted that the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element. "A plurality of" means two or more.

[0074] This application provides a reagent strip 100, which can be used in a sample analyzer.

[0075] Please see Figure 2 , Figure 5 , Figure 6 , Figures 8 to 10 The reagent strip 100 includes a reagent strip body 12 and a capture rod 11.

[0076] The reagent strip body 12 is provided with multiple chambers with top openings, including a sample chamber 12B, a reagent chamber 12C, and a capture rod chamber 12A.

[0077] The sample cavity 12B is used to contain the sample. It should be noted that there can be one or more sample cavities 12B.

[0078] The reagent chamber 12C contains reagents used for sample testing. There can be one or more reagent chambers 12C. It should be noted that some reagent chambers 12C may contain reagents for sample testing, while the remaining reagent chambers 12C are reserved empty cavities. Alternatively, all reagent chambers 12C may contain reagents for sample testing. Among the multiple reagent chambers 12C containing reagents, the reagents in different reagent chambers 12C may be the same or different; there is no restriction on this.

[0079] For example, please refer to Figure 1 The aforementioned cavities also include a photometry cavity 12D. The sample analyzer includes a detection mechanism, which detects the test product prepared based on the sample in the photometry cavity 12D to obtain the sample detection results.

[0080] The sample analyzer includes a sample dispensing mechanism for dispensing samples into the sample chamber 12B.

[0081] For example, samples may include, but are not limited to, at least one of the following: blood, ascites, sputum, and other bodily fluids, but are not limited to these. Sample analyzers are used, for example, to detect specific proteins, peptides, small molecules, etc., in bodily fluids. The test results can reflect the physiological or pathological state of the human body, thus providing a basis for clinical diagnosis and forming the foundation of evidence-based medicine. Sample analyzers may include, but are not limited to, at least one of the following: biochemical analyzers, electrolyte analyzers, immunoassay analyzers, coagulation analyzers, and urine analyzers; for example, the sample analyzer may be a biochemical analyzer, which may include at least one of an immunoassay module, a coagulation analysis module, or a urine analysis module.

[0082] The capture rod cavity 12A is used to place the capture rod 11. That is, the reagent strip 100 provided in this application embodiment is pre-fabricated with the capture rod 11.

[0083] The capture rod 11 includes an interconnected rod-shaped body and a closing structure 112. The rod-shaped body includes a first rod segment 111 located on the bottom side of the closing structure 112. The closing structure 112 is used to openably and close the capture rod cavity 12A. That is, when the capture rod 11 is placed in the capture rod cavity 12A, the closing structure 112 can keep the capture rod cavity 12A closed, with the first rod segment 111 located in the closed capture rod cavity 12A.

[0084] One of the cavity wall of the capture rod cavity 12A and the closed structure 112 is provided with a positioning recess 100B, and the other is provided with a positioning protrusion 100A. The opening of the positioning recess 100B faces or is away from the rod-shaped body. The positioning recess 100B and the positioning protrusion 100A are fitted together to position the capture rod 11 on the reagent strip body 12 and to place the first rod segment 111 suspended in the capture rod cavity 12A.

[0085] The opening of the aforementioned positioning recess 100B faces or faces away from the rod-shaped body. The positioning recess 100B and the positioning protrusion 100A are engaged in the following situations: When the positioning recess 100B is disposed on the cavity wall of the capturing rod cavity 12A, the opening of the positioning recess 100B faces the rod-shaped body, and the positioning protrusion 100A is disposed on the closed structure 112. When the positioning recess 100B is disposed on the closed structure 112, the opening of the positioning recess 100B faces away from the rod-shaped body, and the positioning protrusion 100A is disposed on the cavity wall of the capturing rod cavity 12A, with the positioning protrusion 100A facing the rod-shaped body.

[0086] The aforementioned engagement of the positioning recess 100B and positioning protrusion 100A means that the positioning protrusion 100A passes through the opening of the positioning recess 100B and extends into the positioning recess 100B. In this way, the positioning recess 100B and positioning protrusion 100A form a positioning fit in the extension direction of the rod-shaped body, making it difficult for the two to move relative to each other in the extension direction of the rod-shaped body. This achieves the positioning fit between the cavity wall of the closed structure 112 and the capture rod cavity 12A in the extension direction of the rod-shaped body, thereby positioning the capture rod 11 on the reagent strip body 12.

[0087] The first rod segment 111 is suspended in the capture rod cavity 12A as described above. This means that the first rod segment 111 does not contact the cavity wall of the capture rod cavity 12A. In this way, the probability of the cavity wall of the capture rod cavity 12A and the first rod segment 111 rubbing against each other can be reduced.

[0088] The reagent strip 100 of this application embodiment uses the structure of the capture rod 11 itself to close the capture rod cavity 12A, and also uses the engagement of the positioning recess 100B and the positioning protrusion 100A to achieve the positioning of the capture rod 11. Thus, there is no need to configure an additional outer cover for the reagent strip body 12 to position the capture rod 11. The structure is simple and the operation is convenient.

[0089] The sample analyzer also includes a retrieval mechanism 200 (see reference). Figure 12 When it is necessary to remove the capture rod 11, the retrieval mechanism 200 can directly grab the capture rod 11 without performing the opening action. In this way, it can save time and simplify the retrieval action of the retrieval mechanism 200.

[0090] The cross-sectional shape of the capture rod cavity 12A is not limited; for example, it can be circular, rectangular, elliptical, etc., and there is no restriction here.

[0091] The peripheral shape of the closure structure 112 (the shape of its orthographic projection onto a plane perpendicular to the extension direction of the rod-shaped body) is adapted to the cross-sectional shape of the capturing rod cavity 12A. For example, when the cross-sectional shape of the cavity wall of the capturing rod cavity 12A is circular, the peripheral shape of the closure structure 112 is also circular; when the cross-sectional shape of the cavity wall of the capturing rod cavity 12A is rectangular, the peripheral shape of the closure structure 112 is also rectangular. Preferably, both the peripheral shape of the closure structure 112 and the cross-sectional shape of the capturing rod cavity 12A are perfectly circular, which provides good sealing and ease of processing.

[0092] In some embodiments, the rod-shaped body and the closed structure 112 are separate structures that are interconnected. For example, they can be connected by means of bonding, fusion welding, ultrasonic welding, etc., which helps to improve the sealing performance at the connection between the rod-shaped body and the closed structure 112. Of course, screws, snap-fits, etc. can also be used for connection.

[0093] In some embodiments, the rod-shaped body and the closed structure 112 are integrally formed. This is beneficial for improving the structural strength of the capturing rod 11, and can eliminate the assembly process of the rod-shaped body and the closed structure 112, while also ensuring the sealing of the junction between the closed structure 112 and the rod-shaped body.

[0094] For example, the surface of the first rod segment 111 is further coated with a coating layer, which includes a first substance to be bound and / or a substance capable of binding the first substance to be bound. The first substance to be bound can bind to the target substance in the sample. It should be noted that the binding can be a physical adsorption or a biochemical reaction, such as the binding of an antibody to an antigen.

[0095] For example, the first substance to be bound is an antigen, and the first segment 111 can capture the target substance in the sample, such as an antibody; or the first substance to be bound is an antibody, and the first segment 111 can capture the target substance in the sample, such as an antigen.

[0096] In some embodiments, the reagent includes a second substance to be bound. When the first rod segment 111 is removed from the sample and placed in the reagent, the target substance captured by the first rod segment 111 binds with the second substance to be bound in the reagent to form the test product.

[0097] For example, the reagent may be a secondary antibody reagent linked to a label, preferably a secondary antibody reagent selected from enzyme-labeled or acridinium ester-labeled reagents.

[0098] For example, the first substance to be bound can be coated on the surface of the first segment 111 by adsorption or covalent binding. Taking an antibody as the first substance to be bound, the process of forming a coating layer on the surface of the first segment 111 is as follows:

[0099] 1. Coating: Immerse the first segment 111 in the "avidin-carbonic acid buffer solution" to coat with avidin, and incubate overnight at 4°C.

[0100] 2. Sealing: Remove the first segment 111 from the coating system solution and wash it 3 times with cleaning solution; add sealing solution and incubate at 37°C for 2 hours.

[0101] 3. Drying: Remove the first rod segment 111 from the sealing liquid, absorb the moisture, and dry at 37°C.

[0102] 4. Capture antibody incubation: Immerse the first segment 111 in the "capture antibody-biotin" working solution; incubate at 37°C for 2 hours; then remove the first segment 111 from the "capture antibody-biotin" working solution.

[0103] Exemplarily, at least the first rod segment 111 is a structure made of a non-metallic material. Preferably, the non-metallic material is selected from polymers and silica, and the polymer is selected from at least one of the following: polyethylene, polypropylene, and polystyrene, so that a coating layer is formed on the surface of the first rod segment 111.

[0104] In some embodiments, please refer to Figure 3 and Figure 11 The first rod segment 111 includes a first part 1111 and a second part 1112. The first part 1111 is connected between the second part 1112 and the closed structure 112. The cross-sectional area of ​​the first part 1111 is smaller than the cross-sectional area of ​​the second part 1112.

[0105] At least a portion of the surface of the first rod segment 111 is coated with a layer. The sample chamber 12B is also used for inserting the first rod segment 111 so that the coating layer captures the target substance in the sample. The reagent chamber 12C is also used for inserting the first rod segment 111 so that the target substance captured by the coating layer comes into contact with the reagent; that is, the first rod segment 111 needs to be inserted into the sample chamber 12B first, followed by the reagent chamber 12C. When the first rod segment 111 is inserted into the sample chamber 12B or the reagent chamber 12C, the liquid level in the sample chamber 12B or the reagent chamber 12C is within the height range of the first portion 1111.

[0106] It is understandable that, since the surface of the first rod segment 111 has a coating layer, the contact area between the liquid and the first rod segment 111 will affect the amount of target substance in the sample captured by the coating layer, thereby affecting the measurement results. However, in this embodiment of the present application, the liquid level is controlled within the height range of the first part 1111. When the liquid level fluctuates, since the cross-sectional area of ​​the first part 1111 is smaller than that of the second part 1112, even if the liquid level fluctuates, the contact area between the liquid surface and the first part 1111 is relatively small, which helps to reduce the measurement error caused by the liquid level.

[0107] The cross-sectional shape of the first part 1111 and the cross-sectional shape of the second part 1112 can be the same or different. For example, when the cross-sectional shape of the second part 1112 is circular, the cross-sectional shape of the second part 1112 can be circular, rectangular, polygonal, etc.

[0108] In the extending direction of the second part 1112, the second part 1112 can be configured with a uniform cross-section, that is, the cross-sectional shape and area of ​​the second part 1112 are the same at any part; or it can be configured with a variable cross-section, that is, the cross-sectional shape and / or area of ​​at least two parts of the second part 1112 are different.

[0109] In some embodiments, please refer to Figure 3 and Figure 11 The first part 1111, extending along the closed structure 112 toward the first rod segment 111, sequentially includes a first sub-segment 11111, a necking structure 11112, and a second sub-segment 11113. The necking structure 11112 connects the first sub-segment 11111 and the second sub-segment 11113. That is, the first sub-segment 11111 is located at the end of the necking structure 11112 closer to the closed structure 112, and the second sub-segment 11113 is located at the end of the necking structure 11112 away from the closed structure 112.

[0110] From both axial ends of the first part 1111 towards the necking structure 11112, the cross-sectional areas of the first segment 11111 and the second segment 11113 generally decrease. Specifically, the cross-sectional area of ​​the end of the first segment 11111 furthest from the necking structure 11112 is larger than the cross-sectional area of ​​the end closest to the necking structure 11112. Similarly, the cross-sectional area of ​​the end of the second segment 11113 furthest from the necking structure 11112 is larger than the cross-sectional area of ​​the end closest to the necking structure 11112. The second segment 11113 facilitates the transition from the first part 1111 to the necking structure 11112, and also facilitates the transition between the necking structure 11112 and the end closest to the closed structure 112.

[0111] For example, when the first segment 111 is inserted into the sample chamber 12B or the reagent chamber 12C, the liquid level in the sample chamber 12B or the reagent chamber 12C is within the height range of the necking structure 11112. This helps to further reduce detection errors caused by liquid level fluctuations.

[0112] In some embodiments, the rod-shaped body further includes a second rod segment 113 connected to the top side of the closed structure 112, and the outer periphery of the second rod segment 113 is provided with a gripping engagement structure 1131 for the retrieval mechanism 200 to grip. Due to the force applied by the retrieval mechanism 200, the gripping engagement structure 1131 is less likely to slip in the direction of force application, thereby improving the gripping reliability.

[0113] In some embodiments, the gripping engagement structure 1131 includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment 113. The specific shape of the protruding structure is not limited; for example, it can be an annular shoulder surrounding the outer peripheral surface of the second rod segment 113. The protruding structure can also consist of multiple protrusions arranged at circumferential intervals along the second rod segment 113. The grasping mechanism 200 partially grips the protruding structure, thereby facilitating the application of force to the second rod segment 113.

[0114] In other embodiments, the gripping engagement structure 1131 includes one or more slots recessed into the outer peripheral surface of the second rod segment 113. A portion of the retraction mechanism 200 engages with the slot, thereby facilitating the application of force to the second rod segment 113.

[0115] For example, in some embodiments, the positioning recess 100B and the positioning protrusion 100A are sealed together to achieve the closure of the capture rod cavity 12A by the closing structure 112. That is, after the positioning recess 100B and the positioning protrusion 100A are fitted together, a sealed fit is formed at the contact point between the two. Thus, no other sealing measures are required, and the sealing of the cavity wall of the closing structure 112 and the capture rod cavity 12A is achieved at the same time as positioning.

[0116] In other embodiments, the reagent strip 100 includes a sealing element 122, and the walls of the closed structure 112 and the capture rod cavity 12A are all sealed with the sealing element 122 to achieve a seal between the closed structure 112 and the walls of the capture rod cavity 12A. By using the sealing element 122 to achieve a seal between the closed structure 112 and the walls of the capture rod cavity 12A, the sealing reliability is improved. The mating area between the positioning protrusion 100A and the positioning recess 100B does not need to be sealed, reducing the shape and precision requirements of the positioning protrusion 100A and the positioning recess 100B, and reducing the resistance when the closed structure 112 disengages from the capture rod cavity 12A.

[0117] The seal 122 can be connected to the closed structure 112, or to the cavity wall of the capture rod cavity 12A, or the seal 122 can be an independent component, i.e., the seal 122, the cavity wall of the capture rod cavity 12A, and the closed structure 112 are separate structures.

[0118] The seal 122 is located below or above the mating surface (or mating position) formed by the engagement of the positioning recess 100B and the positioning protrusion 100A. In other words, the seal 122 is staggered from the mating position in the height direction. This minimizes interference between the mating and the seal 122, facilitating structural arrangement.

[0119] Preferably, the seal 122 is located below the mating surface formed by the positioning recess 100B and the positioning protrusion 100A.

[0120] The following is a brief description of six embodiments exemplified in this application, with reference to the accompanying drawings. It should be understood that these six embodiments are only some of the embodiments of this application, and not an exhaustive list of embodiments.

[0121] First Embodiment

[0122] Please see Figures 2 to 4 ,

[0123] The cavity wall of the capture rod cavity 12A is connected to the sealing element 122. Both the sealing structure 112 and the cavity wall of the capture rod cavity 12A are sealed with the sealing element 122 to achieve a seal between the sealing structure 112 and the cavity wall of the capture rod cavity 12A.

[0124] For example, the closed structure 112 has a sealing surface that seals against the sealing element 122. In this embodiment, the sealing of the cavity wall of the closed structure 112 and the capture rod cavity 12A is achieved by the cooperation of the sealing element 122 and the sealing surface. This improves the sealing reliability, and the mating part of the positioning protrusion 100A and the positioning recess 100B does not need to be sealed, reducing the requirements for the shape and precision of the positioning protrusion 100A and the positioning recess 100B.

[0125] The sealing surface is located on the bottom surface of the closed structure 112. The sealing surface is along the direction in which the capture rod 11 is inserted into the capture rod cavity 12A. With the help of the positioning protrusion 100A and the positioning recess 100B, the sealing element 122 undergoes elastic deformation, thereby making the sealing surface and the sealing element 122 seal and abut.

[0126] The seal 122 and the cavity wall of the capture rod cavity 12A can be a separate structure. The seal 122 can be connected to the cavity wall of the capture rod cavity 12A by means of bonding or other methods.

[0127] As a preferred method, please refer to Figure 2 The sealing element 122 and the cavity wall of the capture rod cavity 12A are integrally formed. This helps to improve the sealing reliability and structural reliability at the connection between the sealing element 122 and the cavity wall of the capture rod cavity 12A, and also eliminates the assembly process of the sealing element 122 and the cavity wall of the capture rod cavity 12A.

[0128] For example, the cavity wall of the capture rod cavity 12A and the seal 122 can be made of plastic. Preferably, the cavity wall of the capture rod cavity 12A and the seal 122 are made of polyethylene or polystyrene. It is understood that the wall thickness of the capture rod cavity 12A is greater than the wall thickness of the seal 122. This ensures the structural strength of the cavity wall of the capture rod cavity 12A while allowing the seal 122 to have appropriate deformation, so that the seal 122 can deform appropriately when mating with the sealing surface to meet the sealing performance requirements.

[0129] For example, at least one of the sealing element 122 and the sealing structure 112 at their sealing mating point is provided with an inclined guide surface. That is, the sealing element 122 may have an inclined guide surface, while the sealing structure 112 may not. Alternatively, the sealing element 122 may not have an inclined guide surface, while the sealing structure 112 may have an inclined guide surface. Furthermore, both the sealing element 122 and the sealing structure 112 may have inclined guide surfaces, which abut against each other. The inclined guide surface facilitates the correct alignment of the sealing position of the sealing element 122 and the sealing structure 112, preventing misalignment, and also increases the contact area between the sealing surface and the sealing element 122, thereby improving the sealing reliability of the sealing surface and the sealing element 122.

[0130] Preferably, please refer to Figure 2 and Figure 3 The sealing surface includes a first inclined guide surface 112A. The sealing element 122 is flared in the axial direction and close to the closed structure 112. The inner circumferential surface of the sealing element 122 has a second inclined guide surface 122A. The first inclined guide surface 112A and the second inclined guide surface 122A seal against each other. During assembly, the first inclined guide surface 112A and the second inclined guide surface 122A help to further guide the correct alignment of the sealing position, making it less prone to misalignment, and also help to increase the contact area between the sealing surface and the sealing element 122, thereby improving the sealing reliability of the sealing surface and the sealing element 122.

[0131] For example, please refer to Figure 2 The capture rod cavity 12A includes a first cavity segment 12A1 and a second cavity segment 12A2 arranged along the extension direction of the closed structure 112 toward the first rod segment 111, that is, the first cavity segment 12A1 is closer to the opening of the capture rod cavity 12A than the second cavity segment 12A2.

[0132] The cross-sectional area of ​​the first cavity 12A1 is greater than the cross-sectional area of ​​the second cavity 12A2.

[0133] The cavity walls of the first cavity 12A1 and the second cavity 12A2 are connected by a stepped surface 121.

[0134] When the capture rod 11 is inserted into the capture rod cavity 12A, the closed structure 112 is completely housed in the first cavity 12A1, with a portion of the first rod segment 111 located in the first cavity 12A1 and another portion located in the second cavity 12A2.

[0135] The seal 122 is connected to the stepped surface 121. The sealing surface is located above the stepped surface 121, and the seal 122 seals the gap between the stepped surface 121 and the sealing surface. The stepped surface 121 supports the seal 122, which helps to maintain the preload at the contact point between the seal 122 and the sealing surface, thereby further improving the sealing effect.

[0136] Please see Figure 2 The positioning recess 100B is disposed on the cavity wall of the first cavity segment 12A1, and the sealing structure 112 is entirely located in the first cavity segment 12A1 when sealing the capture rod cavity 12A. In this embodiment, the engagement position of the positioning recess 100B and the positioning protrusion 100A is closer to the opening of the capture rod cavity 12A than the engagement position of the sealing surface and the sealing member 122, that is, the sealing member 122 is located below the engagement surface formed by the engagement of the positioning recess 100B and the positioning protrusion 100A. This embodiment is beneficial to reducing the size of the sealing structure 112 in the extension direction of the rod-shaped body, and is beneficial to the flattening of the sealing structure 112, reducing the depth occupied by the sealing structure 112 in the capture rod cavity 12A. Preferably, the entire sealing structure 112 is located above the sealing member 122.

[0137] In this embodiment, the preload of the seal 122 and the closure structure 112 is provided by the elastic deformation of the seal 122 caused by the engagement of the positioning recess 100B and the positioning protrusion 100A.

[0138] Understandably, in Figure 2 In the embodiment shown, the positions of the positioning recess 100B and the positioning protrusion 100A can be interchanged, that is, the positioning recess 100B is disposed on the closed structure 112, and the positioning protrusion 100A is disposed on the cavity wall of the capture rod cavity 12A.

[0139] For example, please refer to Figure 4 The positioning protrusion 100A includes a plurality of positioning protrusions 100A1 disposed on the outer peripheral surface of the closed structure 112. The positioning recess 100B includes one or more grooves disposed on the cavity wall of the capture rod cavity 12A, and the plurality of positioning protrusions 100A1 are engaged with one or more grooves. In this embodiment, the engagement of the positioning protrusions 100A1 and the grooves can not only satisfy the requirement of positioning the capture rod 11 on the reagent strip body 12, making it less likely for the capture rod 11 to detach from the reagent strip body 12 during transportation and movement, but also help to reduce the force required when the capture rod 11 is inserted into or removed from the capture rod cavity 12A. That is to say, in this embodiment, when the capture rod 11 is inserted into or removed from the capture rod cavity 12A, the capture rod 11 moves in a straight line, which helps to simplify the path of the gripping structure 200 and facilitates operation.

[0140] In this embodiment, the positions of the positioning protrusion 100A and the positioning recess 100B can be interchanged, that is, multiple positioning protrusions 100A1 are disposed on the cavity wall of the capture rod cavity 12A, and one or more recesses are recessed into the outer peripheral surface of the closed structure 112.

[0141] It should be noted that the number of grooves is no more than the number of positioning protrusions 100A1. When there is only one groove, the groove has a relatively long extension length, and all positioning protrusions 100A1 are embedded in the same groove. When there are multiple grooves, the number of grooves can be the same as the number of positioning protrusions 100A1, with each positioning protrusion 100A1 embedded in one groove; the number of grooves can also be less than the number of positioning protrusions 100A1, with some grooves having a moderate extension length, and some of the positioning protrusions 100A1 being embedded in the same groove.

[0142] It should be noted that each positioning protrusion 100A1 and the groove form a fitting position. The number of fitting positions is the same as the number of positioning protrusions 100A1. That is, the positioning protrusions 100A and the positioning recesses 100B have multiple spaced fitting positions arranged circumferentially on the rod-shaped body.

[0143] For example, multiple fitting positions are centrally symmetrical and / or mirror symmetrical with respect to the axis of the rod-shaped body.

[0144] Central symmetry refers to the fact that, in a plane perpendicular to the extension direction of the rod-shaped body, multiple fitting positions can coincide with themselves after being imaginarily rotated 180° around the axis of the rod-shaped body.

[0145] Mirror symmetry refers to the fact that when multiple fitting positions are folded along a straight line passing through the axis of the rod-shaped body in a plane perpendicular to the extension direction of the rod-shaped body, the two parts completely overlap.

[0146] In this embodiment, the multiple fitting positions are centrally symmetrical and / or mirror-symmetrical, which is beneficial to uniformly apply the clamping force to the seal, improve the sealing effect of the seal on the gap between the closed structure and the cavity wall of the capture rod, and enhance the sealing and connection reliability of the sealing structure and the cavity wall of the capture rod cavity 12A. In addition, when the retrieval mechanism 200 takes out the capture rod 11, the force applied by the retrieval mechanism 200 to the capture rod 11 in the circumferential direction is balanced, and it is not easy to cause skew when the capture rod 11 is pulled out.

[0147] It is understood that in this embodiment, the fitting positions are centrally symmetrical and / or mirror-symmetrical, which can also be understood as the multiple positioning protrusions 100A1 being centrally symmetrical and / or mirror-symmetrical.

[0148] For example, the positioning protrusion 100A1 may be generally hemispherical or semi-ellipsoidal in shape.

[0149] In a preferred embodiment, the number of engagement positions is 2 to 6, for example, 2, 3, 4, 5, or 6. In this embodiment, the number of engagement positions can take into account both connection reliability and the force required for the positioning protrusion 100A and positioning recess 100B to engage and disengage.

[0150] In this embodiment, the number of fitting positions is 2 to 6, which can also be understood as the number of positioning protrusions 100A1 being 2 to 6.

[0151] It is understood that in this embodiment, the positions of the positioning recess 100B and the positioning protrusion 100A can be interchanged, that is, the positioning recess 100B is disposed on the cavity wall of the capture rod cavity 12A, and the positioning protrusion 100A is disposed on the closed structure 112.

[0152] In other words, in the above embodiment, the sealing member 122 is located below the mating surface formed by the engagement of the positioning recess 100B and the positioning protrusion 100A. The sealing structure 122 is used to close the opening of the capture rod cavity 12A (this part can be understood as the entire sealing structure 1121 in this embodiment). It also includes a positioning recess 100B or a positioning protrusion 100A, which engages with the positioning recess 100B or the positioning protrusion 100A located on the cavity wall of the capture rod cavity 12A. In this embodiment, the engagement of the positioning protrusion 100A and the positioning recess 100B allows the sealing structure 112 to press the sealing member 112 from the top and bottom, effectively sealing the gap between the sealing structure and the capture rod cavity. This simple design balances the positioning and disengagement of the capture rod from the capture rod cavity with the sealing requirements. Preferably, the sealing member 112 is connected to the capture rod cavity, and both are made of similar materials, making them easier to process.

[0153] Second Embodiment

[0154] Please see Figure 5 In this embodiment, the sealing element 122 is connected to the closed structure 112, and the end of the sealing element 122 away from the closed structure 122 is sealed and abuts against the stepped surface 121.

[0155] The seal 122 and the closure structure 112 can be separate structures, for example, connected by bonding, fusion, ultrasonic welding, etc.

[0156] As a preferred embodiment, the seal 122 and the sealing structure 112 are integrally formed. This improves the sealing reliability and structural reliability at the connection between the seal 122 and the sealing structure 112, and also eliminates the need for assembly steps between the seal 122 and the sealing structure 112.

[0157] Since the material of the sealing structure 112 is relatively hard, while the sealing element 122 is relatively soft, the sealing structure 112 and the sealing element 122 can be made by two-color injection molding.

[0158] At least one of the sealing element 122 and the stepped surface 121 at their sealing mating point is provided with an inclined guide surface. That is, the sealing element 122 may have an inclined guide surface, while the stepped surface 121 may not. Alternatively, the sealing element 122 may not have an inclined guide surface, while the stepped surface 121 may have one. Furthermore, both the sealing element 122 and the stepped surface 121 may have inclined guide surfaces, which abut against each other. The inclined guide surface facilitates the correct alignment of the sealing position of the sealing element 122 and the stepped surface 121, preventing misalignment, and also increases the contact area between the stepped surface 121 and the sealing element 122, thereby improving the sealing reliability of the stepped surface 121 and the sealing element 122.

[0159] Preferably, the entire closed structure 112 is located above the seal 122.

[0160] The remaining structure of the second embodiment is the same as that of the first embodiment, and will not be described again here.

[0161] Third Embodiment

[0162] Please see Figure 6 and Figure 7 In this embodiment, the positioning protrusion 100A is a protruding ring disposed on the outer peripheral surface of the closed structure 112.

[0163] The reagent strip includes a first protruding structure 100B1 and a second protruding structure 100B2. The first protruding structure 100B1 and the second protruding structure 100B2 are disposed on the cavity wall of the capture rod cavity 12A and are arranged at intervals along the extension direction of the rod-shaped body. The interval between the two defines a positioning recess 100B.

[0164] The first protruding structure 100B1 can be discontinuous in the circumferential direction, meaning that the first protruding structure 100B1 will not form a continuous annular structure in the direction surrounding the cavity wall of the capturing rod cavity 12A. Thus, the first protruding structure 100B1 can form multiple engagement positions with the protruding ring. These multiple engagement positions are centrally symmetrical and / or mirror-symmetrical with respect to the axis of the rod-shaped body.

[0165] In this embodiment, the positions of the positioning protrusion 100A and the positioning recess 100B can be interchanged. The first protruding structure 100B1 and the second protruding structure 100B2 can also be disposed on the outer peripheral surface of the closed structure 112, and the protruding ring is disposed on the cavity wall of the capturing rod cavity 12A.

[0166] The remaining structure of the third embodiment is the same as that of the first embodiment, and will not be described again here.

[0167] Fourth embodiment

[0168] Please see Figure 8 In this embodiment, the capture rod cavity 12A does not have a stepped surface, and the capture rod cavity 12A does not distinguish between a first cavity segment and a second cavity segment. The sealing member 122 is connected to the cavity wall of the capture rod cavity 12A, and the sealing member 122 extends upward from the cavity wall of the capture rod cavity 12A and seals against the bottom surface of the closed structure 112.

[0169] Preferably, the seal 122 and the cavity wall of the capture rod cavity 12A are integrally formed.

[0170] Preferably, the entire closed structure 112 is located above the seal 122.

[0171] In this embodiment, the fitting structure of the positioning recess 100B and the positioning protrusion 100A can adopt the structure in the first embodiment or the structure in the third embodiment, and there is no limitation here.

[0172] Fifth embodiment

[0173] Please see Figure 9 Compared to the fourth embodiment, in the fifth embodiment, the sealing element 122 and the closing structure 112 are in a generally horizontal sealing contact. Specifically, the closing structure 112 includes a first closing structure 1121 and a second closing structure 1122 located below the first closing structure 1121. The cross-sectional area of ​​the first closing structure 1121 is larger than that of the second closing structure, forming a stepped structure between them. In this embodiment, the cross-sectional area refers to the area corresponding to the region enclosed by the outer contour in the cross-section.

[0174] The first sealing structure 1121 is fitted into the cavity wall of the capture rod cavity 12A through the positioning recess 100B and the positioning protrusion 100A. The second sealing structure 1122 extends downward and is spaced apart from the cavity wall of the capture rod cavity 12A. When the capture rod 11 is inserted into the capture rod cavity 12A, the sealing member 122 is located between the cavity wall of the capture rod cavity 12A and the outer peripheral surface of the second sealing structure 1122.

[0175] The sealing element 122 is connected to the cavity wall of the capture rod cavity 12A, and the sealing element 122 is in sealing contact with the outer peripheral surface of the second sealing structure 1122. Preferably, the sealing element 122 and the cavity wall of the capture rod cavity 12A are integrally formed structures.

[0176] In this embodiment, the pre-tightening force of the seal 122 and the outer peripheral surface of the second sealing structure 1122 (the direction of the pre-tightening force is approximately perpendicular to the extension direction of the rod-shaped body) depends on the distance between the outer peripheral surface of the second sealing structure 1122 and the cavity wall of the corresponding capture rod cavity 12A. When the size of the seal 122 remains unchanged, the smaller the distance between the outer peripheral surface of the second sealing structure 1122 and the cavity wall of the corresponding capture rod cavity 12A, the greater the pre-tightening force.

[0177] Of course, the seal 122 can also be connected to the outer peripheral surface of the second closed structure 1122 and seal against the cavity wall of the capture rod cavity 12A.

[0178] In this embodiment, the second closed structure 1122 can be a ring-shaped rib structure protruding from the bottom side of the first closed structure 1121, or it can be a block structure, and there is no limitation on this.

[0179] The remaining structure of the fifth embodiment can be the same as that of the fourth embodiment, and will not be described again here.

[0180] Sixth Embodiment

[0181] Please see Figure 10 and Figure 11 In this embodiment, the capture rod cavity 12A includes a first cavity segment 12A1 and a second cavity segment 12A2 arranged along the extension direction of the closed structure 112 toward the first rod segment 111. The cavity walls of the first cavity segment 12A1 and the second cavity segment 12A2 are connected by a stepped surface 121.

[0182] The closed structure 112 includes a first closed portion 1121 and a second closed portion 1122 arranged along the extension direction of the closed structure 112 toward the first rod segment 111, wherein the cross-sectional area of ​​the first closed portion 1121 is greater than the cross-sectional area of ​​the second closed portion 1122.

[0183] When the capture rod 11 is inserted into the capture rod cavity 12A, the first sealing part 1121 is located in the first cavity 12A1 and closes the opening of the capture rod cavity 12A. Part of the second sealing part 1122 is located in the second cavity 12A2.

[0184] The seal 122 is connected to the stepped surface 121. The bottom surface of the first sealing part 1121 has a sealing surface, which is located above the stepped surface 121. The seal 122 seals the gap between the stepped surface 121 and the sealing surface.

[0185] As a preferred embodiment, the seal 122 and the cavity wall of the capture rod cavity 12A are integrally formed. This improves the sealing reliability and structural reliability at the connection between the seal 122 and the cavity wall of the capture rod cavity 12A, and also eliminates the assembly process between the seal 122 and the cavity wall of the capture rod cavity 12A.

[0186] A positioning protrusion 100A is disposed on the cavity wall of the second cavity segment 12A2, and a positioning recess 100B is disposed on the outer peripheral surface of the second sealing portion 1122. The cavity wall of the second cavity segment 12A2 and the second sealing portion 1122 are positioned by the engagement of the positioning protrusion 100A and the positioning recess 100B.

[0187] In this embodiment, the seal 122 is located above the mating surface formed by the positioning recess 100B and the positioning protrusion 100A. That is, the positioning recess 100B and the positioning protrusion 100A are closer to the lower part of the capture rod cavity 12A. Therefore, the centering effect of the first rod segment 111 is better, and the first rod segment 111 is less likely to be scratched by the cavity wall of the capture rod cavity 12A.

[0188] In this embodiment, the positioning protrusion 100A may include a plurality of positioning protrusions as in the first embodiment, so that the positioning protrusion 100A and the positioning recess 100B form a plurality of spaced-apart fitting positions in the circumferential direction.

[0189] It is understood that in this embodiment, the positions of the positioning protrusion 100A and the positioning recess 100B can be interchanged, that is, the positioning protrusion 100A is disposed on the outer peripheral surface of the lower part 1122 of the closed structure 112, and the positioning recess 100B is disposed on the cavity wall of the cavity segment 12A2.

[0190] It is understood that in this embodiment, the seal 122 can also be connected to the bottom surface of the upper part 1122 of the closed structure 112. Preferably, the seal 122 can be integrally formed with the closed structure 112.

[0191] In this embodiment, the sealing member 122 is located above the mating surface formed by the positioning recess 100B and the positioning protrusion 100A. The upper part of the sealing structure 122 (which can be understood as the first sealing structure 1121) and the lower part of the sealing structure (which can be understood as the second sealing structure 1122) are fitted with the cavity wall of the capture rod cavity 12A through the positioning recess 100B or the positioning protrusion 100A. In this embodiment, the sealing structure 112 is divided into two functional areas. The upper functional area is used to cover the opening of the capture rod cavity 12A, and the lower functional area is used to position the capture rod 11 with the capture rod cavity 12A, so that the antibody-coated capture rod 11 is stably suspended in the capture rod cavity 12A. The sealing member 122 seals the gap between the sealing structure 112 and the capture rod cavity 12A through the middle part of the sealing structure 112.

[0192] It should be noted that in the above six embodiments, the structure of the first rod segment 111 can be the same or different. The structure of the second rod segment 113 can be the same or different.

[0193] It is understood that in the first to sixth embodiments shown above, during the insertion or removal of the capture rod 11 into or out of the capture rod cavity 12A, the capture rod 11 moves in a straight line. During the engagement of the positioning protrusion 100A and the positioning recess 100B, compression occurs approximately in the direction perpendicular to the straight line movement of the capture rod 11. During the compression process, the positioning protrusion 100A and / or the positioning recess 100B undergo a small amount of reversible deformation.

[0194] It should be noted that the positioning protrusion 100A and / or positioning recess 100B are provided with a guide structure to facilitate the relative movement of the positioning protrusion 100A and / or positioning recess 100B when the capture rod 11 is inserted into or removed from the capture rod cavity 12A, thereby facilitating the insertion and removal of the capture rod 11.

[0195] In other embodiments not shown, the positioning protrusion 100A includes a helical protrusion, and both the helical protrusion and the helical groove extend helically around the axis of the rod-shaped body, with the helical protrusion and the helical groove engaging helically. That is, the closed structure 112 and the cavity wall of the capture rod cavity 12A are threadedly engaged. When the capture rod 11 is inserted into or removed from the capture rod cavity 12A, the capture rod 11 performs a helical movement. In this embodiment, even if the capture rod 11 is accidentally touched by an external force, the capture rod 11 is not easily dislodged from the capture rod cavity 12A.

[0196] This application provides a capture rod 11 for use with a reagent strip 100, for example, it can be used with the reagent strip 100 in any of the above embodiments.

[0197] The capture rod 11 includes a rod-shaped body and a closed structure 112.

[0198] The rod-shaped body includes a first rod segment 111. A coating layer is formed on the surface of the first rod segment 111.

[0199] The closed structure 112 surrounds the outer periphery of the rod-shaped body and is connected to the rod-shaped body, with the first rod segment 111 located on the first side of the closed structure 112. For example, when the capture rod 11 is placed in the chamber of the reagent strip 100, the first side is the bottom side of the closed structure 112, and the first rod segment 111 is located on the bottom side of the closed structure 112.

[0200] The first segment 111 includes a first part 1111 and a second part 1112. The first part 1111 is connected between the second part 1112 and the closed structure 112. The cross-sectional area of ​​the first part 1111 is smaller than the cross-sectional area of ​​the second part 1112.

[0201] In this embodiment, when the first rod segment 111 is placed into the sample chamber 12B or the reagent chamber 12C, the liquid level in the sample chamber 12B or the reagent chamber 12C is within the height range of the first part 1111.

[0202] It is understandable that, since the surface of the first rod segment 111 has a coating layer, the contact area between the liquid and the first rod segment 111 will affect the amount of target substance in the sample captured by the coating layer, thereby affecting the measurement results. In this embodiment of the present application, the liquid level is controlled within the height range of the first part 1111. When the liquid level fluctuates, since the cross-sectional area of ​​the first part 1111 is smaller than that of the second part 1112, even if the liquid level fluctuates, the contact area between the liquid surface and the first part 1111 is relatively small, which helps to reduce the measurement error caused by the liquid level.

[0203] For example, the reagent strip 100 also includes a capture rod cavity 12A for placing the capture rod 11. The outer peripheral surface of the closed structure 112 is provided with a positioning recess 100B or a positioning protrusion 100A. The positioning recess 100B or the positioning protrusion 100A is used to fit into the cavity wall of the capture rod cavity 12A so that the first rod segment 111 of the capture rod 11 is suspended in the capture rod cavity 12A.

[0204] The capture rod 11 is positioned by using its own structure to seal the capture rod cavity 12A, and by using the structure of the sealing structure 112 and the cavity wall of the capture rod cavity 12A. Thus, there is no need to configure an additional outer cover for the reagent strip body 12 to position the capture rod 11. The structure is simple and the operation is convenient.

[0205] When the reagent strip 100 is applied to the sample analyzer, the sample analyzer's retrieval mechanism 200 can directly remove the capture rod 11 without needing to open the cap. This saves time and simplifies the retrieval action of the retrieval mechanism 200.

[0206] For example, the rod-shaped body includes a second rod segment 113, which is connected to the second side of the closed structure 112. The first side and the second side are opposite to each other. The outer periphery of the second rod segment 113 is provided with a gripping engagement structure 1131 for the retrieval mechanism 200 to grip. Due to the force applied by the retrieval mechanism 200, the gripping engagement structure 1131 is less likely to slip in the direction of force application, thus improving the gripping reliability.

[0207] In some embodiments, the gripping engagement structure 1131 includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment 113. The specific shape of the protruding structure is not limited; for example, it can be an annular shoulder surrounding the outer peripheral surface of the second rod segment 113. The protruding structure can also consist of multiple protrusions arranged at circumferential intervals along the second rod segment 113. The grasping mechanism 200 partially grips the protruding structure, thereby facilitating the application of force to the second rod segment 113.

[0208] In other embodiments, the gripping engagement structure 1131 includes one or more slots recessed into the outer peripheral surface of the second rod segment 113. A portion of the retraction mechanism 200 engages with the slot, thereby facilitating the application of force to the second rod segment 113.

[0209] Other structures of the capture rod 11 can refer to the structure of the capture rod 11 in any of the above embodiments, and will not be described again here.

[0210] This application provides a sample analyzer, including a sample analysis module and a reagent strip 100 in any embodiment of this application.

[0211] The sample analysis module includes a reagent strip storage area 100, a sample dispensing mechanism, a retrieval mechanism 200, and a testing mechanism.

[0212] The reagent strip 100 storage area can hold at least one reagent strip 100.

[0213] The sample dispensing mechanism is used to dispense the sample into the sample chamber 12B of the reagent strip 100.

[0214] The retrieval mechanism 200 is used to drive the capture rod 11 of the reagent strip 100 to move.

[0215] Testing agencies use these instruments to analyze samples. For example, they can excite the analyte, such as a marker bound to a target substance, to emit light, and then measure parameters such as the intensity of the light emission. Based on the test results, the concentration of the target substance in the sample can be determined, for example.

[0216] The controller is used to control the retrieval mechanism 200 to remove the capture rod 11 from the capture rod cavity 12A, and to control the detection mechanism to detect the sample.

[0217] In the sample analyzer of this application embodiment, the reagent strip 100 uses the capture rod 11 itself to close the capture rod cavity 12A, and also uses the engagement of the positioning recess 100B and the positioning protrusion 100A to position the capture rod 11. Thus, there is no need to configure an additional outer cover for the reagent strip body 12 to position the capture rod 11, the structure is simple and the operation is convenient; the retrieval mechanism 200 can directly take out the capture rod 11 without performing the opening action, thus saving time and simplifying the retrieval action of the retrieval mechanism 200.

[0218] In some embodiments, the test strip 100 further includes a pipette 12, and the multiple cavities also include a pipette cavity 103, in which a pipette 12 is pre-positioned. The sample dispensing mechanism 120 can be connected to the pipette 12 in the test strip 10010, using the pipette 12 to aspirate the sample and add the aspirated sample to the sample cavity 12B of the test strip 10010; afterwards, the pipette 12 can be unloaded into the pipette cavity 103. However, this is not the only embodiment; for example, in other embodiments, the sample dispensing mechanism 120 can add the aspirated sample to the sample cavity 12B using a sample needle, after which the sample needle is cleaned.

[0219] In some embodiments, please refer to Figure 11The retrieval mechanism 200 includes a claw 201 and a rod-shaped body including a second rod segment 113. The second rod segment 113 is connected to the side of the closed structure 112 away from the first rod segment 111. The outer periphery of the second rod segment 113 is provided with a gripping engagement structure 1131 for the claw 201 to grip. The controller controls the claw 201 of the retrieval mechanism 200 to grip the gripping engagement structure 1131 on the capture rod 11 and move upward linearly to remove the capture rod 11 from the capture rod cavity 12A. During the upward movement, the positioning protrusion 100A and the positioning recess 100B disengage from each other, thereby allowing the capture rod 11 to be removed from the capture rod cavity 12A.

[0220] This application provides a sample analyzer, including a sample analysis module and a reagent strip 100.

[0221] The test strip 100 includes a capture rod 11 and a test strip body 12. The test strip body 12 has multiple chambers with top openings. The multiple chambers include a sample chamber 12B, a reagent chamber 12C, and a capture rod chamber 12A.

[0222] The capture rod 11 includes an interconnected rod-shaped body and a closed structure 112, which is detachably connected to and closes the capture rod cavity 12A.

[0223] The sample chamber 12B is used to contain the sample. The sample analyzer includes a sample dispensing mechanism, which dispenses the sample into the sample chamber 12B when the reagent strip 100 is in use.

[0224] For example, samples may include, but are not limited to, at least one of the following: blood, ascites, sputum, and other bodily fluids, but are not limited to these. Sample analyzers are used, for example, to detect specific proteins, peptides, small molecules, etc., in bodily fluids. The test results can reflect the physiological or pathological state of the human body, thus providing a basis for clinical diagnosis and forming the foundation of evidence-based medicine. Sample analyzers may include, but are not limited to, at least one of the following: biochemical analyzers, electrolyte analyzers, immunoassay analyzers, coagulation analyzers, and urine analyzers; for example, the sample analyzer may be a biochemical analyzer, which may include at least one of an immunoassay module, a coagulation analysis module, or a urine analysis module.

[0225] The reagent chamber 12C contains reagents used for sample testing.

[0226] The capture rod cavity 12A is used to place the capture rod 11. That is, the reagent strip 100 provided in this application embodiment is pre-fabricated with the capture rod 11.

[0227] The sample analysis module includes a reagent strip 100 storage area, a sample dispensing mechanism, a retrieval mechanism 200, a testing mechanism, and a controller.

[0228] The reagent strip 100 storage area can hold at least one reagent strip 100, and at least the top surface of the closed structure 112 is exposed to the environment of the reagent strip 100 storage area. That is, the closed structure 112 has no outer cover, so that the closed structure 112 is exposed to the environment of the reagent strip 100 storage area.

[0229] The sample dispensing mechanism is used to dispense the sample into the sample chamber 12B of the reagent strip 100.

[0230] The retrieval mechanism 200 is used to drive the capture rod 11 of the reagent strip 100 to move.

[0231] Testing agencies are used to test products prepared based on samples.

[0232] The controller is used to control the retrieval mechanism 200 to move to the position of the reagent strip 100, grasp the capture rod 11, remove the capture rod 11 from the capture rod cavity 12A, and control the detection mechanism to detect the product to be tested.

[0233] In this embodiment of the sample analyzer, when the retrieval mechanism 200 retrieves the capture rod 11, it moves to the position of the reagent strip 100 without opening the cap. It can directly grab the capture rod 11 and remove it, which is simple and convenient.

[0234] In some embodiments, the rod-shaped body includes a first rod segment 111 and a second rod segment 113, which are located on opposite sides of the closed structure 112. The first rod segment 111 is suspended in the capture rod cavity 12A. The first rod segment 111 is located on the bottom side of the closed structure 112, and the second rod segment 113 is located on the top side of the closed structure 112. The top surfaces of both the second rod segment 113 and the closed structure 112 are exposed to the environment of the reagent strip 100 storage area.

[0235] The outer periphery of the second rod segment 113 is provided with a gripping engagement structure 1131 for the gripper 201 to grasp. The controller controls the retrieval mechanism 200 to grasp the gripping engagement structure 1131 and move it upward linearly to remove the capture rod 11 from the capture rod cavity 12A. This simplifies the power path of the retrieval structure, making operation simple and convenient.

[0236] The specific structure of the gripping and mating structure 1131 can be referred to in any of the above embodiments of the gripping and mating structure 1131, and will not be described again here.

[0237] For example, one of the cavity wall of the capture rod cavity 12A and the closed structure 112 is provided with a positioning recess 100B, and the other is provided with a positioning protrusion 100A. The opening of the positioning recess 100B faces or is away from the rod-shaped body. The positioning recess 100B and the positioning protrusion 100A are fitted together to position the capture rod 11 on the reagent strip body 12 and to place the first rod segment 111 suspended in the capture rod cavity 12A.

[0238] In this embodiment, the capture rod cavity 12A is closed by the structure of the capture rod 11 itself, and the positioning of the capture rod 11 is achieved by the fitting of the positioning recess 100B and the positioning protrusion 100A. Thus, there is no need to configure an additional outer cover for the reagent strip body 12 to position the capture rod 11. The structure is simple and the operation is convenient.

[0239] The positioning recess 100B and the positioning protrusion 100A can refer to the structure of the positioning recess 100B and the positioning protrusion 100A in any of the above embodiments, and will not be described again here.

[0240] In the description of this application, the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the embodiments of this application. In this application, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Furthermore, without contradiction, those skilled in the art can combine different embodiments or examples described in this application, as well as features of different embodiments or examples.

[0241] The above description is merely a preferred embodiment of this application and is not intended to limit the application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of protection of this application.

Claims

1. A reagent strip, characterized in that, include: The reagent strip body has multiple chambers with top openings, including a sample chamber, a reagent chamber, and a capture rod chamber. The sample chamber is used to hold the sample; the reagent chamber holds reagents used for sample detection. The capture rod cavity is used to place the capture rod; A capture rod includes interconnected rod-shaped bodies and a closed structure, wherein the rod-shaped bodies include a first rod segment located on the bottom side of the closed structure; the closed structure is used to openably and close the cavity of the capture rod. The cavity wall of the capture rod cavity and one of the closed structures are provided with a positioning recess, and the other is provided with a positioning protrusion. The opening of the positioning recess faces or is away from the rod-shaped body. The positioning recess and the positioning protrusion are fitted together to position the capture rod on the reagent strip body and to place the first rod segment in the capture rod cavity in a suspended position.

2. The reagent strip according to claim 1, characterized in that, The rod-shaped main body and the closed structure are integrally formed.

3. The reagent strip according to claim 1, characterized in that, The positioning recess and positioning protrusion are sealed together to achieve a seal between the closed structure and the cavity wall of the capture rod cavity.

4. The reagent strip according to claim 1, characterized in that, The reagent strip includes a sealing element, and the sealing structure and the cavity wall of the capture rod cavity are both sealed with the sealing element to achieve a seal between the sealing structure and the cavity wall of the capture rod cavity; Preferably, the sealing element and the cavity wall of the capture rod cavity are integrally formed, or the sealing element and the sealing structure are integrally formed.

5. The reagent strip according to claim 4, characterized in that, The sealing element is located below or above the mating surface formed by the positioning recess and the positioning protrusion; preferably, the sealing element is located below the mating surface formed by the positioning recess and the positioning protrusion.

6. The reagent strip according to claim 4, characterized in that, The sealing element is located above the mating surface formed by the positioning recess and the positioning protrusion. The upper part of the sealing structure closes the opening of the capture rod cavity, and the lower part of the sealing structure and the cavity wall of the capture rod cavity are mated by the positioning recess and the positioning protrusion; or, The sealing element is located below the mating surface formed by the positioning recess and the positioning protrusion. The sealing structure is used to close the opening of the capture rod cavity. It also provides the positioning recess or the positioning protrusion and is mated with the positioning recess or positioning protrusion provided on the cavity wall of the capture rod cavity.

7. The reagent strip according to claim 4, characterized in that, When the sealing element is fixedly connected to the closed structure, at least one of the sealing element and the cavity wall of the capture rod cavity at the sealing joint is provided with an inclined guide surface; or, when the sealing element is fixedly connected to the cavity wall of the capture rod cavity, at least one of the sealing element and the closed structure at the sealing joint is provided with an inclined guide surface.

8. The reagent strip according to any one of claims 1-5, characterized in that, The capture rod cavity includes a first cavity segment and a second cavity segment arranged along the extension direction of the closed structure toward the first rod segment. The cross-sectional area of ​​the first cavity segment is larger than that of the second cavity segment. The cavity walls of the first cavity segment and the cavity walls of the second cavity segment are connected by a stepped surface. At least a portion of the closed structure is accommodated in the first cavity segment, and at least a portion of the first rod segment is located in the second cavity segment.

9. The reagent strip according to claim 8, characterized in that, The bottom side of the closed structure has a sealing surface, which is located above the stepped surface. The reagent strip includes a sealing element, which is disposed between the sealing surface and the stepped surface and seals the gap between the sealing surface and the stepped surface.

10. The reagent strip according to claim 8, characterized in that, The upper part of the closed structure is located in the first cavity section, and the lower part of the closed structure is located in the second cavity section. The positioning recess or the positioning protrusion is provided and engages with the positioning recess or the positioning protrusion provided on the cavity wall of the capture rod cavity.

11. The reagent strip according to claim 8, characterized in that, The positioning recess or the positioning protrusion is disposed on the cavity wall of the first cavity segment, and the sealing structure is located entirely within the first cavity segment when sealing the capture rod cavity; Alternatively, the closed structure includes a first closed portion and a second closed portion arranged along the extension direction of the closed structure toward the first rod segment, the cross-sectional area of ​​the first closed portion being larger than the cross-sectional area of ​​the second closed portion, the first closed portion being located in the first cavity segment, and at least a portion of the second closed portion extending into the second cavity segment; one of the positioning recess and the positioning protrusion is disposed on the cavity wall of the second cavity segment, and the other is disposed on the second closed portion.

12. The reagent strip according to claim 1, characterized in that, The positioning protrusion includes a protruding ring or multiple positioning protrusions; and / or The positioning recess includes one or more grooves, or the reagent strip includes a first protruding structure and a second protruding structure, the first protruding structure and the second protruding structure being arranged at intervals along the extension direction of the rod-shaped body, and the interval between them defining the positioning recess.

13. The reagent strip according to claim 1, characterized in that, The positioning protrusion and the positioning recess have multiple spaced-apart fitting positions on the circumference of the rod-shaped body, and the multiple fitting positions are centrally symmetrical and / or mirror-symmetrical with respect to the axis of the rod-shaped body; preferably, The number of the interlocking positions is 2 to 6.

14. The reagent strip according to claim 1, characterized in that, The positioning protrusion includes a spiral protrusion, and both the spiral protrusion and the spiral groove extend spirally around the axis of the rod-shaped body, and the spiral protrusion and the spiral groove are spirally engaged.

15. The reagent strip according to any one of claims 1-14, characterized in that, The first rod segment includes a first part and a second part, the first part being connected to one end of the second part near the closed structure, wherein the cross-sectional area of ​​the first part is smaller than the cross-sectional area of ​​the second part; At least a portion of the surface of the first rod segment is covered with a coating layer; The sample cavity is used to insert the first rod segment so that the coating layer can capture the target substance in the sample; The reagent chamber is used to insert the first rod segment so that the target substance captured by the coating layer comes into contact with the reagent. When the first rod segment is placed into the sample chamber or the reagent chamber, the liquid level in the sample chamber or the reagent chamber is within the height range of the first part; preferably, the first part includes a first sub-segment, a necking structure, and a second sub-segment in sequence along the extension direction of the closed structure toward the first rod segment, the necking structure connecting the first sub-segment and the second sub-segment, and the cross-sectional area of ​​the first sub-segment and the second sub-segment generally decreases from both ends of the first part toward the direction close to the necking structure.

16. The reagent strip according to any one of claims 1-14, characterized in that, The rod-shaped body also includes a second rod segment connected to the top side of the closed structure, and the outer periphery of the second rod segment is provided with a gripping engagement structure for the retrieval mechanism to grip. Preferably, the gripping engagement structure includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment; or, the gripping engagement structure includes one or more slots recessed into the outer peripheral surface of the second rod segment.

17. A trapping rod, characterized in that, For use with reagent strips, the capture rod includes: The rod-shaped main body includes the first rod segment; A closed structure surrounds the outer periphery of the rod-shaped body and is connected to the rod-shaped body, with the first rod segment located on the first side of the closed structure. The first rod segment includes a first part and a second part, the first part being connected between the second part and the closed structure, and the cross-sectional area of ​​the first part being smaller than that of the second part.

18. The capture rod according to claim 17, characterized in that, The reagent strip also includes a capture rod cavity for placing the capture rod. The outer peripheral surface of the closed structure is provided with a positioning recess or a positioning protrusion. The positioning recess or the positioning protrusion is used to fit into the cavity wall of the capture rod cavity so that the first rod segment of the capture rod is suspended in the capture rod cavity.

19. The capture rod according to claim 17, characterized in that, The rod-shaped body includes a second rod segment, which is connected to the second side of the closed structure. The first side and the second side are opposite to each other. The outer periphery of the second rod segment is provided with a gripping engagement structure for the retrieval mechanism to grip. Preferably, the gripping engagement structure includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment; or, the gripping engagement structure includes one or more slots recessed into the outer peripheral surface of the second rod segment.

20. A sample analyzer, characterized in that, include: Sample analysis module and reagent strips, The reagent strip includes a capture rod and a reagent strip body. The reagent strip body has multiple chambers with a top-side opening. The multiple chambers include a sample chamber, a reagent chamber, and a capture rod chamber. The capture rod includes an interconnected rod-shaped body and a sealing structure. The sealing structure is detachably connected to the capture rod chamber and seals the capture rod chamber. The sample analysis module includes: A reagent strip storage area, wherein at least one of the reagent strips can be placed in the reagent strip storage area, and at least the top surface of the enclosed structure is exposed to the environment of the reagent strip storage area; A sample dispensing mechanism, wherein the sample dispensing mechanism is used to dispense the sample into the sample cavity of the reagent strip; A retrieving mechanism for driving the movement of the capture rod of the reagent strip; A testing organization, which is used to test the test product prepared based on the sample; The controller is used to control the retrieving mechanism to move to the position of the reagent strip, grasp the capture rod, remove the capture rod from the capture rod cavity, and control the detection mechanism to detect the product to be tested.

21. The sample analyzer according to claim 20, characterized in that, The rod-shaped body includes a first rod segment and a second rod segment, the first rod segment and the second rod segment are located on opposite sides of the closed structure, and the first rod segment is suspended in the capture rod cavity; The outer periphery of the second rod segment is provided with a gripping engagement structure for the retrieval mechanism to grasp; The controller is used to control the retrieval mechanism to grasp the grasping engagement structure and move upward in a straight line to remove the capture rod from the capture rod cavity; Preferably, the gripping engagement structure includes a protruding structure that protrudes from the outer peripheral surface of the second rod segment; or, the gripping engagement structure is one or more slots recessed into the outer peripheral surface of the second rod segment.

22. The sample analyzer according to claim 20, characterized in that, The cavity wall of the capture rod cavity and one of the closed structures are provided with a positioning recess, and the other is provided with a positioning protrusion. The opening of the positioning recess faces or is away from the rod-shaped body. The positioning recess and the positioning protrusion are fitted together to position the capture rod on the reagent strip body, and the part of the rod-shaped body located below the closed structure is suspended in the capture rod cavity.

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