A method for preparing a signal enhancement electrode for an invasive brain-machine interface
By combining two-dimensional boron-based materials with graphene oxide, signal enhancement electrodes were prepared, solving the problems of electrode compliance and stability in invasive brain-computer interfaces and achieving high-quality neural signal acquisition.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- JIANGMEN DUAL CARBON LAB
- Filing Date
- 2026-04-20
- Publication Date
- 2026-07-10
AI Technical Summary
Existing traditional metal electrodes or rigid electrodes have problems such as insufficient flexibility, high interfacial impedance and poor long-term stability in invasive brain-computer interfaces, making it difficult to meet the requirements of high-quality signal acquisition and long-term biocompatible contact.
A signal enhancement electrode was fabricated by combining a two-dimensional boron-based material with graphene oxide. The two-dimensional boronyne material was prepared by mixing it with an aqueous solution of graphene oxide and then undergoing freeze-thaw treatment, followed by pressure molding.
It improves the conductivity and interface compatibility of the electrodes, reduces the contact impedance between the electrodes and biological tissues, enhances signal transmission capability and interface contact stability, and improves the acquisition effect of neural electrical signals.
Smart Images
Figure CN122350718A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of flexible electronic materials and devices, and specifically discloses a method for preparing a signal enhancement electrode for invasive brain-computer interfaces. Background Technology
[0002] Brain-computer interfaces (BCIs) are an important technology for enabling information exchange between the brain and external devices, with broad application prospects in fields such as the diagnosis and treatment of neurological diseases, motor function reconstruction, intelligent prosthesis control, and neuroscience research. Based on the different ways electrodes contact biological tissue, BCIs can generally be divided into non-invasive, semi-invasive, and invasive types. Among them, invasive BCIs, by placing electrodes directly inside the brain tissue or near the brain surface, can obtain neural electrical signals with higher spatial and temporal resolution, thus having a significant advantage in high-precision neural information acquisition and decoding.
[0003] The performance of invasive brain-computer interfaces (BCIs) largely depends on the electrode materials and their interface structure. An ideal invasive electrode not only needs good conductivity and signal transmission capabilities, but also low tissue interface contact impedance, high mechanical compliance, and good biocompatibility to reduce mechanical mismatch between the electrode and soft tissue after implantation, and minimize interface damage and signal attenuation. However, existing traditional metal electrodes or conventional rigid electrodes typically suffer from insufficient compliance, high interface impedance, and poor long-term implantation stability, making it difficult to simultaneously meet the requirements of invasive BCIs for high-quality signal acquisition and long-term biocompatible contact.
[0004] With the development of flexible electronics technology, constructing flexible electrodes based on flexible polymer substrates and functional nanomaterials has become an important research direction for improving the performance of brain-computer interface electrodes. Graphene, graphene oxide, and their derivatives have attracted widespread attention in the field of bioelectrodes due to their high specific surface area, excellent conductivity, and certain flexibility. However, single-material systems still have certain limitations in terms of interfacial conductivity, structural stability, and adaptability to complex physiological environments, especially in reducing contact resistance, improving electrode flexibility, and enhancing long-term stability.
[0005] Two-dimensional boron-based materials, due to their unique electronic structure, excellent conductivity, and potential interface control capabilities, have shown great application potential in flexible electronic devices and bioelectronic materials. Combining two-dimensional boron-based materials with graphene oxide is expected to combine the advantages of both in terms of conductivity, flexibility, and interface compatibility, thereby improving the contact state between electrodes and biological tissues, reducing interfacial impedance, and enhancing device stability and signal acquisition performance.
[0006] Therefore, there is an urgent need to provide a method for manufacturing signal enhancement electrodes suitable for invasive brain-computer interfaces, so as to obtain flexible electrodes with good conductivity, low interface impedance, mechanical compliance and biological stability, to meet the application requirements of invasive brain-computer interfaces for high-performance neural signal acquisition devices. Summary of the Invention
[0007] The purpose of this invention is to provide a method for preparing signal enhancement electrodes for invasive brain-computer interfaces, so as to solve the problems existing in the prior art.
[0008] The technical solution adopted in this invention is as follows: A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material.
[0009] Further, step S1 specifically includes: Step S1.1: Dissolve the boron dimethyl sulfide complex and the boron pinacol ester in an organic solvent and disperse them by stirring to obtain a precursor mixture; Step S1.2: The precursor mixture is subjected to thermal reaction to obtain a two-dimensional boryne material; Step S1.3: After mixing the two-dimensional boron yne material with the graphene oxide aqueous solution, freeze the mixture until it is completely frozen, and then thaw it in a vacuum environment to obtain the two-dimensional boron-based graphene oxide composite material.
[0010] Furthermore, in step S1.1, the organic solvent is selected from one or more of naphthalene-2,7-dicarboxylic acid, neopentyl glycol diacrylate, and diallyl malonate; the precursor mixture is dispersed by magnetic stirring, mechanical stirring, or ultrasonic dispersion.
[0011] Furthermore, in step S1.2, the precursor mixture is placed in a tube furnace for thermal reaction. The thermal reaction is carried out under an inert atmosphere or a protective atmosphere, including nitrogen and / or argon. The temperature of the thermal reaction is 300~1200℃, and the reaction time is 0.5~10h.
[0012] Furthermore, in step S1.2, the heating rate of the thermal reaction is 5~8℃ / min.
[0013] Furthermore, in step S1.3, the two-dimensional boryne material and the graphene oxide aqueous solution are mixed at a mass ratio of 1:(0.1~10); the freezing temperature is -20 ~ -40 ℃, and vacuum thawing is carried out under negative pressure until the frozen system is completely thawed.
[0014] Further, step S2 specifically involves placing the thawed two-dimensional boron-based graphene oxide composite material in a mold and pressing it to form a signal enhancement electrode for invasive brain-computer interfaces.
[0015] Furthermore, in step S2, the pressure for pressurization is 1~50 MPa, and the time is 10~90 min.
[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: 1) This invention combines two-dimensional boron-based materials with graphene oxide, giving full play to the synergistic effect of two-dimensional boron-based materials and carbon-based materials in terms of conductivity, interface compatibility and structural regulation, thereby improving the signal transmission capability of the electrode.
[0017] 2) The present invention adopts a composite treatment method combining freezing and vacuum thawing, which is beneficial to improving the composite uniformity and structural stability between two-dimensional boryne materials and graphene oxide, thereby improving the overall stability and interfacial contact performance of the prepared electrode.
[0018] 3) The signal enhancement electrode prepared by the present invention can effectively reduce the impedance of the interface between the electrode and biological tissue, enhance the stability of the interface contact, and thus improve the neural electrical signal acquisition effect in invasive brain-computer interfaces.
[0019] 4) The preparation process of the present invention is simple and operable, and the parameter range is adjustable, which makes it easy to optimize the material composite ratio, reaction conditions and molding conditions according to different application requirements, and has high feasibility and application value.
[0020] 5) The signal enhancement electrode prepared by this invention has good flexibility and biocompatibility, and can form a relatively stable contact state at the interface with biological tissue, thus making it suitable for the field of invasive brain-computer interfaces. Detailed Implementation
[0021] It is readily understood that, based on the technical solution of this invention, those skilled in the art can propose various interchangeable structural methods and implementations without altering the essential spirit of the invention. Therefore, the following detailed embodiments and accompanying drawings are merely illustrative examples of the technical solution of this invention and should not be considered as the entirety of the invention or as limitations or restrictions on the technical solution of this invention. Attached Figure Description
[0022] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Wherein: Figure 1 The images show the actual brain-computer interface electrodes and EEG test data of Example 1. Figure 2 The images show the actual brain-computer interface electrodes and EEG test data from Example 2. Figure 3 The images show the actual brain-computer interface electrodes and EEG test data of Example 3; Figure 4 The images show the actual brain-computer interface electrodes and EEG test data of Example 4; Figure 5 The images show the actual brain-computer interface electrodes and EEG test data from Example 5. Figure 6 The images show the actual brain-computer interface electrodes and EEG test data of Example 6; Figure 7 The image shows the actual brain-computer interface electrode and EEG test data of Example 7; Figure 8 The image shows the actual brain-computer interface electrode and EEG test data of Example 8; Figure 9 The image shows the actual brain-computer interface electrode and EEG test data of Example 9; Figure 10 The image shows the actual brain-computer interface electrode and EEG test data of Example 10; Figure 11 This is a physical image of the two-dimensional boron-based graphene oxide composite material of Example 1.
[0023] Example 1 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 1.0 g of borane dimethyl sulfide complex and 1.0 g of boron pinacol ester, add them to 20 mL of neopentyl glycol diacrylate, and disperse them at room temperature by magnetic stirring for 2 h to obtain the precursor mixture; Step S1.2: Place the precursor mixture in a tube furnace, heat it to 600°C at 5°C / min under a nitrogen protective atmosphere, and hold it for 2 hours to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boronyne material with the graphene oxide aqueous solution at a mass ratio of 1:1, stir evenly, and then freeze at -30°C until completely frozen. Subsequently, place under vacuum until the frozen system is completely thawed, obtaining the desired result. Figure 11 The two-dimensional boron-based graphene oxide composite material shown; Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 10 MPa for 30 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0024] Example 1 like Figure 1 As shown in (a) and (b), the signal enhancement electrode for invasive brain-computer interfaces is obtained using the materials and preparation method of Example 1; Figure 1 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0025] Example 2 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 1.5g of borane dimethyl sulfide complex and 1.2g of boron pinacol ester, add them to 25mL diallyl malonate, and disperse them by mechanical stirring for 1.5h to obtain a precursor mixture. Step S1.2: Place the precursor mixture in a tube furnace, heat it to 700°C at 8°C / min under a nitrogen protective atmosphere, and hold it for 1 hour to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:0.5, stir evenly, and then freeze in an environment of -25°C until completely frozen. Then place it in a vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 15 MPa for 20 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0026] Example 2 like Figure 2 As shown in (a) and (b), the signal enhancement electrode for invasive brain-computer interfaces was obtained using the materials and preparation method of Example 2; Figure 2 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0027] Example 3 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 0.8 g of borane dimethyl sulfide complex and 1.0 g of boron pinacol ester, add them to 20 mL of naphthalene-2,7-dicarboxylic acid, and treat with ultrasonic dispersion for 1 h to obtain precursor mixture; Step S1.2: Place the precursor mixture in a tube furnace, heat it to 500°C under a nitrogen protective atmosphere, and hold it for 3 hours to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:2, stir evenly, and then freeze in an environment of -35°C until completely frozen. Then place it in a vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 8 MPa for 40 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0028] Example 3 like Figure 3 As shown in (a) and (b), these are signal enhancement electrodes for invasive brain-computer interfaces obtained using the materials and preparation method of Example 3; Figure 3 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0029] Example 4 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 2.0 g of borane dimethyl sulfide complex and 1.5 g of diboron pinacol ester, add them to 30 mL of a mixed organic solvent composed of neopentyl glycol diacrylate and diallyl malonate in a volume ratio of 1:1, and treat for 2 h by a combination of magnetic stirring and ultrasonic dispersion to obtain a precursor mixture. Step S1.2: Place the precursor mixture in a tube furnace, heat it to 800°C under a nitrogen / argon mixed protective atmosphere, and hold it at that temperature for 1.5 hours to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:3, stir evenly, and then freeze in an environment of -40°C until completely frozen. Then place it in a negative pressure vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 20 MPa for 25 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0030] Example of effect 4 like Figure 4 As shown in (a) and (b), these are signal enhancement electrodes for invasive brain-computer interfaces obtained using the materials and preparation method of Example 4; Figure 4 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0031] Example 5 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 1.2g of borane dimethyl sulfide complex and 0.9g of boron pinacol ester, add them to 18mL of neopentyl glycol diacrylate, and treat with mechanical stirring for 3h to obtain the precursor mixture. Step S1.2: Place the precursor mixture in a tube furnace, heat it to 900°C under an argon protective atmosphere, and hold it at that temperature for 0.5 h to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:0.1, stir evenly, and then freeze in an environment of -20°C until completely frozen. Then place it in a negative pressure vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 5 MPa for 60 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0032] Example 5 like Figure 5 As shown in (a) and (b), the signal enhancement electrode for invasive brain-computer interfaces was obtained using the materials and preparation method of Example 5; Figure 5 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0033] Example 6 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 1.0 g of borane dimethyl sulfide complex and 1.8 g of boron pinacol ester, add them to 28 mL of diallyl malonate, and treat with ultrasonic dispersion for 1.5 h to obtain precursor mixture; Step S1.2: Place the precursor mixture in a tube furnace, heat it to 1000°C under a nitrogen protective atmosphere, and hold it for 1 hour to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:5, stir evenly, and then freeze in an environment of -32°C until completely frozen. Then place it in a negative pressure vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 30 MPa for 15 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0034] Example 6 like Figure 6 As shown in (a) and (b), the signal enhancement electrode for invasive brain-computer interfaces was obtained using the materials and preparation method of Example 6; Figure 6 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0035] Example 7 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 0.5g of borane dimethyl sulfide complex and 0.6g of boron pinacol ester, add them to 15mL of a mixed organic solvent composed of naphthalene-2,7-dicarboxylic acid and neopentyl glycol diacrylate, and treat with magnetic stirring for 2.5h to obtain a precursor mixture. Step S1.2: Place the precursor mixture in a tube furnace, heat it to 300°C under an argon protective atmosphere, and hold it for 10 hours to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:10, stir evenly, and then freeze in an environment of -28°C until completely frozen. Then place it in a negative pressure vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 1 MPa for 90 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0036] Example 7 like Figure 7 As shown in (a) and (b), these are signal enhancement electrodes for invasive brain-computer interfaces obtained using the materials and preparation method of Example 7; Figure 7 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0037] Example 8 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 2.5g of borane dimethyl sulfide complex and 2.0g of boron pinacol ester, add them to 35mL of a mixed organic solvent composed of diallyl malonate and neopentyl glycol diacrylate, and treat with mechanical stirring combined with ultrasonic dispersion for 2h to obtain a precursor mixture. Step S1.2: Place the precursor mixture in a tube furnace, heat it to 1200°C under nitrogen protection, and hold it for 0.5 h to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:8, stir evenly, and then freeze in an environment of -40°C until completely frozen. Then place it in a negative pressure vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 50 MPa for 10 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0038] Example 8 like Figure 8 As shown in (a) and (b), these are signal enhancement electrodes for invasive brain-computer interfaces obtained using the materials and preparation method of Example 8; Figure 8 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0039] Example 9 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 1.3g of borane dimethyl sulfide complex and 1.1g of boron pinacol ester, add them to 22mL of neopentyl glycol diacrylate, treat with magnetic stirring for 1h, and then ultrasonically disperse for 30min to obtain the precursor mixture. Step S1.2: Place the precursor mixture in a tube furnace, heat it to 650°C under nitrogen protection, and hold it for 4 hours to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:1.5, stir evenly, and then freeze in an environment of -30°C until completely frozen. Then place it in a negative pressure vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 12 MPa for 35 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0040] Example 9 like Figure 9 As shown in (a) and (b), the signal enhancement electrode for invasive brain-computer interfaces was obtained using the materials and preparation method of Example 9; Figure 9 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0041] Example 10 A method for fabricating a signal enhancement electrode for an invasive brain-computer interface includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S1.1: Weigh 1.8g of borane dimethyl sulfide complex and 1.8g of diboron pinacol ester, add them to 30mL of a mixed organic solvent composed of naphthalene-2,7-dicarboxylic acid, diallyl malonate and neopentyl glycol diacrylate, and treat with mechanical stirring for 2h, followed by ultrasonic dispersion for 1h to obtain the precursor mixture. Step S1.2: Place the precursor mixture in a tube furnace, heat it to 750°C under argon protection, and hold it for 2.5 hours to obtain a two-dimensional boronyne material. Step S1.3: Mix the two-dimensional boron yne material with the graphene oxide aqueous solution at a mass ratio of 1:4, stir evenly, and then freeze in an environment of -36°C until completely frozen. Then place it in a negative pressure vacuum environment until the frozen system is completely thawed to obtain a two-dimensional boron-based graphene oxide composite material. Step S2: A signal enhancement electrode for invasive brain-computer interface is prepared using a two-dimensional boron-based graphene oxide composite material. Specifically, the two-dimensional boron-based graphene oxide composite material is placed in a mold and pressurized at 25 MPa for 30 min to obtain the signal enhancement electrode for invasive brain-computer interface.
[0042] Example 10 like Figure 10 As shown in (a) and (b), the signal enhancement electrode for invasive brain-computer interfaces is obtained using the materials and preparation method of Example 10; Figure 10 As shown in (c), this is the EEG test data of the signal enhancement electrode.
[0043] The technical scope of this invention is not limited to the content described above. Those skilled in the art can make various modifications and variations to the above embodiments without departing from the technical concept of this invention, and all such modifications and variations should fall within the protection scope of this invention.
Claims
1. A method for fabricating a signal enhancement electrode for an invasive brain-computer interface, characterized in that, Includes the following steps: Step S1: Prepare two-dimensional boron-based graphene oxide composite material; Step S2: Use the two-dimensional boron-based graphene oxide composite material to prepare a signal enhancement electrode for invasive brain-computer interface.
2. The method for fabricating a signal enhancement electrode for an invasive brain-computer interface according to claim 1, characterized in that, Step S1 specifically includes: Step S1.1: Dissolve the boron dimethyl sulfide complex and the boron pinacol ester in an organic solvent and disperse them by stirring to obtain a precursor mixture; Step S1.2: The precursor mixture is subjected to a thermal reaction to obtain a two-dimensional boryne material; Step S1.3: After mixing the two-dimensional boron yne material with the graphene oxide aqueous solution, freeze the mixture until it is completely frozen, and then thaw it in a vacuum environment to obtain a two-dimensional boron-based graphene oxide composite material.
3. The method for fabricating a signal enhancement electrode for an invasive brain-computer interface according to claim 2, characterized in that, In step S1.1, the organic solvent is selected from one or more of naphthalene-2,7-dicarboxylic acid, neopentyl glycol diacrylate, and diallyl malonate; the precursor mixture is dispersed by magnetic stirring, mechanical stirring, or ultrasonic dispersion.
4. The method for fabricating a signal enhancement electrode for an invasive brain-computer interface according to claim 2, characterized in that, In step S1.2, the precursor mixture is placed in a tube furnace for thermal reaction. The thermal reaction is carried out under an inert atmosphere or a protective atmosphere, including nitrogen and / or argon. The temperature of the thermal reaction is 300~1200℃ and the reaction time is 0.5~10h.
5. The method for fabricating a signal enhancement electrode for an invasive brain-computer interface according to claim 4, characterized in that, In step S1.2, the heating rate of the thermal reaction is 5~8℃ / min.
6. The method for fabricating a signal enhancement electrode for an invasive brain-computer interface according to claim 2, characterized in that, In step S1.3, the two-dimensional boryne material and the graphene oxide aqueous solution are mixed at a mass ratio of 1:(0.1~10); the freezing temperature is -20 ~ -40 ℃, and vacuum thawing is carried out under negative pressure until the frozen system is completely thawed.
7. The method for fabricating a signal enhancement electrode for an invasive brain-computer interface according to claim 2, characterized in that, Step S2 specifically involves placing the thawed two-dimensional boron-based graphene oxide composite material in a mold and pressing it to form a signal enhancement electrode for invasive brain-computer interfaces.
8. The method for fabricating a signal enhancement electrode for an invasive brain-computer interface according to claim 7, characterized in that, In step S2, the pressure for pressurization is 1~50 MPa and the time is 10~90 min.