Ultrasonic activated nanomaterials for promoting healing of diabetic wounds and methods of making and using the same
By using ultrasound-activated nanomaterials that load zinc oxide nanoparticles onto graphite-diyne nanosheets and modify them with L-arginine, the problems of insufficient phototherapy penetration and limited chemokinetics were solved, achieving a synergistic effect of deep sterilization and tissue repair, and promoting the healing of diabetic wounds.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHENGZHOU UNIV
- Filing Date
- 2026-05-06
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies suffer from problems such as insufficient penetration depth of phototherapy, limitations of wound microenvironment in chemokinetics, and the difficulty of achieving both deep sterilization and tissue repair simultaneously with a single antibacterial mode.
A sonic-activated nanomaterial, consisting of graphdiyne nanosheets loaded with zinc oxide nanoparticles and modified with L-arginine, is used to generate reactive oxygen species through ultrasonic activation, which then oxidizes L-arginine to release nitric oxide, thus achieving a synergistic effect between sonic dynamic therapy and nitric oxide gas therapy.
It achieves synergistic treatment of deep antibacterial and active repair promotion, significantly promotes the healing of diabetic wounds, has highly efficient antibacterial properties and good biocompatibility, and avoids the risk of drug leakage.
Smart Images
Figure CN122399019A_ABST