pH-responsive covalent nucleic acid nanoprobes, methods of making and using the same
By designing pH-responsive covalent nucleic acid nanoprobes and activating them in the acidic tumor microenvironment, we have achieved highly specific and long-lasting imaging of nucleic acid aptamers in tumor sites. This solves the problems of non-specificity and unstable binding of nucleic acid aptamers in tumor imaging and provides safe imaging results with a high signal-to-noise ratio.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUNAN UNIV
- Filing Date
- 2026-05-06
- Publication Date
- 2026-07-17
AI Technical Summary
Existing nucleic acid aptamer probes have problems such as non-specific recognition, unstable binding, and short imaging duration in tumor imaging. Traditional improvement strategies have safety risks or limited penetration depth.
A pH-responsive covalent nucleic acid nanoprobe was designed, comprising a pH-responsive nucleic acid structural unit, a target recognition unit, and a covalent reaction unit. It is activated by the acidic tumor microenvironment and binds to target cell surface proteins through a proximity-driven effect by forming stable covalent bonds.
It achieves highly specific and long-lasting imaging at tumor sites, reduces off-target effects, improves the imaging signal-to-noise ratio, and requires no external stimulation under intrinsic conditions, thus possessing safety and universality.
Smart Images
Figure CN122399063A_ABST