Glioma electric field combined CAR-T treatment system, method and application

By using a closed-loop feedback control mechanism, combined with CAR-T data and multimodal sensing data, the electric field output mode is adjusted, which solves the problems of timing coordination and safety control in glioma electric field combined with CAR-T therapy. It achieves matching and safety interlocking between electric field output and CAR-T cell state, thereby improving the safety and effectiveness of treatment.

CN122399250APending Publication Date: 2026-07-17THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
Filing Date
2026-06-17
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In glioma electric field combined with CAR-T therapy, existing technologies suffer from insufficient timing coordination, conflict between the CAR-T cell expansion phase and the fixed electric field output parameters, and safety control challenges such as cytokine release, neurotoxicity risks, and interference with EEG signal monitoring.

Method used

It employs an electric field output module, a CAR-T data interface, a multimodal electrode interface, a sensor acquisition module, and a control module. By receiving CAR-T-related data and multimodal sensor data, it achieves closed-loop feedback regulation, generates frequency, field strength, pulse duty cycle, phase, start/stop, or alarm control commands, adjusts the electric field output mode to match the CAR-T state, and performs safety interlock control when impedance, temperature, EEG, implant, and metabolic load are abnormal.

Benefits of technology

It improves the adaptability of electric field output to CAR-T cell state, enhances the safety control capability of system operation, reduces the risk of neurotoxicity and monitoring interference, and ensures the safety and effectiveness of treatment.

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Abstract

本发明公开了一种基胶质瘤电场联合CAR‑T治疗系统、方法及应用，涉及肿瘤电场治疗、细胞免疫治疗和生物医学工程技术领域。该系统包括电场输出模块、CAR‑T数据接口、多模态电极接口、传感采集模块和控制模块。控制模块根据CAR‑T制剂信息、回输时间、外周血淋巴细胞计数或CAR‑T拷贝数，以及温度、阻抗、脑电、生化指标和影像建模数据，切换基准输出模式、增殖保护输出模式和安全联锁输出模式，并生成频率、场强、脉冲占空、相位、启停或报警控制指令。该系统能够根据CAR‑T扩增状态调节电场输出，并在异常风险出现时进行联锁控制。
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Citation Information

Patent Citations

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