Synthesis method of astringent active component DMAG and intermediate thereof
The preparation of DMAG via a three-step reaction using ellagic acid as the starting material solves the problem of low natural DMAG content in Sanguisorba officinalis and realizes an efficient and simple synthesis method suitable for industrial production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-30
- Publication Date
- 2026-07-17
AI Technical Summary
In existing technologies, the natural content of DMAG in Sanguisorba officinalis is low, and the separation and purification process is complex, resulting in limited product quantity and high price, which makes it difficult to meet the needs of research and application.
Using ellagic acid as the starting material, DMAG was prepared through a three-step reaction: methylation, glycosylation, and deprotection. The specific steps included methylation using potassium carbonate and iodomethane, glycosylation using β-bromoglucotetraacetic acid, and deprotection in ammonia-methanol solution. The reaction conditions were mild and the operation was simple.
The method achieves efficient preparation of DMAG with a total yield of 22.5%. The reaction steps are simple and suitable for industrial production, solving the problem of low efficiency in natural extraction.
Smart Images
Figure CN122404450A_ABST