Systems and methods for analysis of isobaric labeling experiments
By using a windowed super-resolution algorithm to process mass spectrometry data in isoweight labeling analysis, the problem of high-resolution requirements was solved, efficient quantification of low-resolution mass spectrometry data was achieved, and the application scope of isoweight labeling experiments was expanded.
CN122422979APending Publication Date: 2026-07-17THERMO FISHER SCI BREMEN
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- THERMO FISHER SCI BREMEN
- Filing Date
- 2024-12-20
- Publication Date
- 2026-07-17
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Figure CN122422979A_ABST
Abstract
提供了同重标记实验的定量的方法和系统。提供的方法包括：获得样品的第一组质谱数据，其中所述样品包含多种同重标识分析物，根据所述第一组质谱数据确定所述多种同重标识分析物中的所选同重标识分析物的互补离子的相应预测质量，获得所述样品的碎裂部分的质谱仪输出，所述部分含有所述所选同重标识分析物，将窗口化超分辨率算法应用于所述质谱仪输出以生成第二组质谱数据，其中所述窗口化超分辨率算法的窗口基于所述互补离子的所述预测质量来确定，以及根据所述第二组质谱数据对存在于所述样品中的所述分析物进行定量。
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