A ceramide composition having a long-lasting repair efficacy and a method of preparing the same

Abstract

This invention discloses a ceramide composition with long-lasting repair effects and its preparation method, relating to the cosmetics field. This ceramide composition effectively solves the technical problem of ceramide precipitation by rationally adjusting the ratio of its components, ensuring good physicochemical stability under high and low temperatures and long-term storage conditions. Ceramides, in synergistic effect with phytosterols, behenol, etc., significantly reduce transepidermal water loss, enhance skin hydration, accelerate the repair of damaged barriers, and form a long-lasting protective film on the skin surface, ensuring the durability of the repair effect. Through optimized formulation and process, a product with stable and excellent pearlescent effect can be prepared without relying on mica-based pearlescent agents, avoiding safety issues such as pore blockage or skin irritation that pearlescent powder may cause. In summary, this application overcomes the shortcomings of insufficient repair durability in existing technologies, providing a ceramide composition with both excellent stability and significant long-lasting repair effects.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, and more specifically, to a ceramide composition with long-lasting repair effects and a method for preparing the same. Background Technology

[0002] Ceramides are the main components of intercellular lipids in the stratum corneum of the skin. Together with cholesterol and free fatty acids, they form the core structure of the skin barrier and play a key role in maintaining skin moisture and resisting external stimuli.

[0003] However, ceramides are highly crystalline, have poor solubility in aqueous systems, poor compatibility with other components in cosmetics, and are prone to precipitation in high and low temperature environments, making long-term stable storage difficult. To address this issue, existing technologies disclose methods that utilize water-soluble polymers to form protective colloids from microparticle ceramides for stabilization. However, this technique, by microparticleizing the ceramide crystals, results in insufficient integration with the stratum corneum, hindering its full moisturizing and repairing effects. Another technique involves covalently introducing ceramides into hyaluronic acid molecules; however, this method results in an overly strong bond between ceramides and hyaluronic acid, insufficiently leveraging the barrier repair function of ceramides themselves.

[0004] When the amount of ceramide added exceeds a certain level, stability tests under high and low temperature and freeze-thaw cycles often fail. Therefore, how to increase the amount of ceramide added while ensuring the long-term stability of the composition and fully exerting its skin barrier repair efficacy remains a technical challenge that urgently needs to be solved in this field.

[0005] In view of this, the present invention is proposed. Summary of the Invention

[0006] The purpose of this invention is to provide a ceramide composition with long-lasting repair effects and a method for preparing the same.

[0007] This invention is implemented as follows: In a first aspect, embodiments of the present invention provide a composition comprising: a ceramide mixture, phytosterols, behenol, hydrogenated lecithin, alcohol compounds, poloxamer 407, and water; wherein the ceramide mixture comprises: ceramide NP, ceramide AP, ceramide EOP, and ceramide EOS in a mass ratio of (8~12):(2~3):(0.5~1.5):(0.5~1.5).

[0008] Secondly, embodiments of the present invention provide a formulation with skin barrier repair function, which contains the composition described in the foregoing embodiments.

[0009] Thirdly, embodiments of the present invention provide a method for preparing an agent with skin barrier repair function as described in the foregoing embodiments, which includes mixing the composition described in the foregoing embodiments.

[0010] Fourthly, embodiments of the present invention provide a cosmetic product comprising the composition described in the foregoing embodiments, the formulation described in the foregoing embodiments, or the formulation prepared by the preparation method described in the foregoing embodiments.

[0011] The present invention has the following beneficial effects: The ceramide composition provided in this application effectively solves the technical problem of ceramide precipitation under high concentration conditions by rationally adjusting the ratio of each component, enabling the composition to maintain good physicochemical stability under high and low temperatures and long-term storage conditions. Simultaneously, the ceramide in the composition works synergistically with phytosterols, behenol, and other components to significantly reduce transepidermal water loss (TEWL), enhance skin hydration, accelerate the repair of damaged skin barriers, and form a long-lasting protective film on the skin surface, ensuring the durability of the repair effect. Furthermore, the composition of this application does not contain animal-derived cholesterol, avoiding the safety risks and source limitations that may arise from animal-derived ingredients, and is more in line with environmental protection and sustainable development principles. In addition, by optimizing the ratio and process, this application can also prepare a product with stable and excellent pearlescent effect, which can be achieved without relying on traditional mica-based pearlescent agents, avoiding safety issues such as pore blockage or skin irritation that may arise from pearlescent powder. In summary, this application effectively overcomes the technical obstacle of insufficient durability of the repair effect of ceramides in the prior art, providing a ceramide composition with excellent stability and significant and long-lasting skin barrier repair efficacy. Attached Figure Description

[0012] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 The image shows the appearance of the pearlescent composition in experimental group 1. Figure 2 This is an image of the transparent composition in experimental group 6. Figure 3 This is a particle size distribution diagram of the transparent composition in experimental group 6. Detailed Implementation

[0014] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0015] On one hand, embodiments of the present invention provide a composition comprising: a mixture of ceramides, phytosterols, behenol, hydrogenated lecithin, alcohols, poloxamer 407, and water; The ceramide mixture comprises ceramide NP, ceramide AP, ceramide EOP and ceramide EOS in a mass ratio of (8~12):(2~3):(0.5~1.5):(0.5~1.5).

[0016] In some embodiments, the phytosterols are selected from one or more of β-sitosterol, stigmasterol, campesterol, and phytosterol / octyldodecyl lauroyl glutamate.

[0017] In some embodiments, the mass ratio of the ceramide mixture, the phytosterols, and the behenol is (2-4):(0.5-1.5):(0.5-1.5). Specifically, the mass ratio of the ceramide mixture to the phytosterols can be any one of 2:1, 2.5:1, 3:1, 3.5:1, 4:1, or any combination thereof. The mass ratio of the ceramide mixture to the behenol can be any one of 2:1, 2.5:1, 3:1, 3.5:1, 4:1, or any combination thereof.

[0018] In some embodiments, the composition comprises, by weight, 0.1 to 12 parts of a ceramide mixture, 0.1 to 5 parts of phytosterols, 0.1 to 5 parts of behenol, 1 to 5 parts of hydrogenated lecithin, 10 to 70 parts of an alcohol compound, 0.1 to 7 parts of poloxamer 407, and 20 to 70 parts of water, wherein the alcohol compound comprises at least one of butylene glycol and glycerol.

[0019] In some embodiments, the weight parts of the ceramide mixture may be any one or a range between any two of 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 11.5 and 12 parts.

[0020] In some embodiments, the weight parts of phytosterols may be any one or any combination of 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, and 5 parts.

[0021] In some embodiments, the weight parts of behenol can be any one of 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, or 5 parts, or any range between any two.

[0022] In some embodiments, the hydrogenated lecithin may be in any one or a range between any two of the following weights: 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 and 5 parts.

[0023] In some embodiments, the weight parts of the alcohol compound may be any one or any combination of 10, 20, 30, 40, 50, 60 and 70 parts.

[0024] In some embodiments, the weight parts of butylene glycol or glycerin may be any one of 10, 15, 20, 25, 30, 35 and 40 parts or a range between any two.

[0025] In some embodiments, the parts by weight of poloxamer 407 may be any one or a range between any two of 0.1, 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.4, 1.6, 1.8, 2, 2.2, 2.4, 2.6, 2.8, 3, 3.2, 3.4, 3.6, 3.8, 4, 4.2, 4.4, 4.6, 4.8, 5, 5.5, 6, 6.5, and 7 parts.

[0026] In some embodiments, the water by weight can be any one or a range between any two of 20, 25, 30, 35, 40, 45, 50, 55, 60, 65 and 70 parts.

[0027] In some embodiments, the composition comprises, by weight percentage: 0.1% to 12% ceramide mixture, 0.1% to 5% phytosterols, 0.1% to 5% behenol, 1% to 5% hydrogenated lecithin, 10% to 70% alcohols, 0.1% to 7% poloxamer 407, with the balance being water, wherein the alcohols include at least one of butylene glycol and glycerol.

[0028] In some embodiments, the mass percentage of the ceramide mixture can be any one or a range between any two of 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10%, 10.5%, 11%, 11.5%, and 12%.

[0029] In some embodiments, the mass percentage of phytosterols or behenol can be any one or a range between any two of 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% and 5%.

[0030] In some embodiments, the mass percentage of hydrogenated lecithin can be any one or a range between any two of 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% and 5%.

[0031] In some embodiments, the mass percentage of the alcohol compound can be any one or a range between any two of 10%, 20%, 30%, 40%, 50%, 60%, and 70%.

[0032] In some embodiments, the mass percentage of butylene glycol or glycerol can be any one or a range between any two of 10%, 15%, 20%, 25%, 30%, 35%, and 40%.

[0033] In some embodiments, the mass percentage of poloxamer 407 can be any one or a range between any two of the following: 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, 2.2%, 2.4%, 2.6%, 2.8%, 3%, 3.2%, 3.4%, 3.6%, 3.8%, 4%, 4.2%, 4.4%, 4.6%, 4.8%, 5%, 5.5%, 6%, 6.5%, and 7%.

[0034] By adjusting the components and their proportions in the composition, both pearlescent and transparent dissolution appearance products can be obtained.

[0035] In some embodiments, the composition comprises, by weight, 2.5 to 12 parts of a ceramide mixture, 0.1 to 5 parts of phytosterols, 0.1 to 5 parts of behenol, 1 to 5 parts of hydrogenated lecithin, 10 to 40 parts of butylene glycol, 10 to 30 parts of glycerol, 0.1 to 2 parts of poloxamer 407 and 20 to 70 parts of water.

[0036] In some embodiments, the composition comprises, by weight, 0.1 to 2 parts of a ceramide mixture, 0.1 to 5 parts of phytosterols, 0.1 to 5 parts of behenol, 1 to 5 parts of hydrogenated lecithin, 10 to 40 parts of butylene glycol, 10 to 30 parts of glycerol, 2 to 7 parts of poloxamer 407 and 20 to 70 parts of water.

[0037] In some embodiments, the composition comprises, by weight percentage: 2.5% to 12% ceramide mixture, 0.1% to 5% phytosterols, 0.1% to 5% behenol, 1% to 5% hydrogenated lecithin, 10% to 40% butylene glycol, 10% to 30% glycerol, 0.1% to 2% poloxamer 407, with the balance being water.

[0038] In some embodiments, the composition comprises, by weight percentage: 0.1% to 2% ceramide mixture, 0.1% to 5% phytosterols, 0.1% to 5% behenol, 1% to 5% hydrogenated lecithin, 10% to 40% butylene glycol, 10% to 30% glycerol, 2% to 7% poloxamer 407, with the balance being water.

[0039] On the other hand, embodiments of the present invention provide a formulation with skin barrier repair function, which contains the composition described in any of the foregoing embodiments.

[0040] On the other hand, embodiments of the present invention provide a method for preparing an agent with skin barrier repair function as described in any of the foregoing embodiments, which includes mixing the composition described in any of the foregoing embodiments.

[0041] In some embodiments, the preparation steps of the preparation method include: The oil phase components are mixed and then heated to 80-90°C to dissolve, thereby obtaining the oil phase; the oil phase components include a mixture of ceramides, phytosterols, behenol, hydrogenated lecithin, and butylene glycol; The aqueous phase components are mixed and heated to 80-90°C to obtain an aqueous phase; the aqueous phase components include glycerol, poloxamer 407 and water. The aqueous phase is added to the oil phase for emulsification; The emulsified product was homogenized.

[0042] In some embodiments, the heating temperature of the oil phase component or the aqueous phase component can be any one of 80, 82, 84, 86, 88 and 90°C or a range between any two.

[0043] In some embodiments, the emulsification conditions are 2000~5000 rpm for 5~15 min; the rpm can be any one or a range between any two of 2000, 2500, 3000, 3500, 4000, 4500 and 5000 rpm; the time can be any one or a range between any two of 5, 6, 8, 10, 12, 14 and 15 min.

[0044] In some embodiments, the homogenization is high-speed shearing and / or high-pressure homogenization, wherein the high-speed shearing conditions are 8000~12000 rpm for 3~5 min. The rotational speed can be any one or a range between 8000, 9000, 10000, 11000, and 12000 rpm. The time can be any one or a range between 3, 4, and 5 min.

[0045] The high-pressure homogenization conditions are 600-800 bar, repeated 1-3 times. The pressure can be any one of 600, 650, 700, 750, and 800 bar, or any combination thereof. The number of cycles can be any one of 1, 2, and 3, or any combination thereof.

[0046] In some embodiments, after homogenization, the preparation method further includes: Cooling: Cool the homogenized product to a set temperature, wherein the set temperature is 40~50℃; Isothermal aging: Maintain at the set temperature for 20-40 minutes; Cooling: Cool to room temperature at a rate of 1~5℃ / min.

[0047] In some embodiments, the cooling rate during the cooling phase is 0.5~2.0℃ / min, specifically any one or any two of 0.5, 0.6, 0.8, 1, 1.2, 1.4, 1.6, 1.8 and 2℃ / min.

[0048] In some embodiments, the set temperature can be any one of 40, 42, 44, 46, 48 and 50°C or a range between any two.

[0049] In some embodiments, the holding time for isothermal aging can be any one or a range between any two of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38 and 40 min.

[0050] In some embodiments, the cooling rate during the cooling phase can be any one or a range between any two of 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 and 5 °C / min.

[0051] Furthermore, embodiments of the present invention also provide a cosmetic product comprising the composition described in any of the foregoing embodiments, the formulation described in any of the foregoing embodiments, or the formulation prepared by the preparation method described in any of the foregoing embodiments.

[0052] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0053] In the tables of examples and comparative examples: NP is ceramide NP, AP is ceramide AP, EOP is ceramide EOP, EOS is ceramide EOS, and the subsequent ceramide mixture refers to a mixture of ceramide NP, ceramide AP, ceramide EOP and ceramide EOS; butanediol is 1,3-butanediol; "%" is mass percentage.

[0054] Example 1 This embodiment provides a ceramide composition, the formulation of which is shown in Table 1.

[0055] Table 1 Formulation of ceramide compositions

[0056] Example 2 This embodiment provides a ceramide composition, the formulation of which is shown in Table 2.

[0057] Table 2 Formulation of ceramide compositions

[0058] Example 3 This embodiment provides a method for preparing a pearlescent ceramide composition, the steps of which are as follows: (1) Oil phase heating: A mixture of ceramides, phytosterols, behenol, hydrogenated lecithin and 1,3-butanediol was mixed, heated to 85°C, and stirred thoroughly until completely melted and homogeneous to obtain the oil phase; (2) Aqueous phase preparation: Glycerin, poloxamer 407 and deionized water were mixed and heated to 85°C to obtain an aqueous phase. (3) Preliminary emulsification: Under stirring conditions of 3000 rpm, the aqueous phase was gradually added to the oil phase and stirred for 8 min. (4) High-speed shearing: The system was initially homogenized by homogenizing and shearing at 12,000 rpm for 3 minutes. (5) Slow cooling: Slowly cooling to 40℃ at a rate of 0.5℃ / min, during which ceramide molecules gradually arrange themselves in an orderly manner, is a key window for the self-assembly of laminar liquid crystals. (6) Isothermal aging: By maintaining a constant temperature of 40℃ for 20 min, the layered liquid crystal structure is fully self-assembled and crystallized. During this stage, lipid molecules diffuse and rearrange fully under conditions close to the phase transition temperature, forming a highly ordered layered structure, which gives the product a stable pearlescent appearance. (7) Final cooling: The mixture was cooled to room temperature (25±2℃) at a rate of 1℃ / min to "lock" the formed layered liquid crystal structure and obtain a pearlescent composition.

[0059] Example 4 This embodiment provides a method for preparing a transparent ceramide composition, the steps of which are as follows: (1) Oil phase heating: A mixture of ceramides, phytosterols, behenol, hydrogenated lecithin and 1,3-butanediol was mixed, heated to 80°C, and stirred thoroughly until completely melted and homogeneous to obtain the oil phase; (2) Aqueous phase preparation: Glycerin, poloxamer 407 and deionized water were mixed and heated to 80°C to obtain an aqueous phase. (3) Preliminary emulsification: Under stirring conditions of 2000 rpm, the aqueous phase was gradually added to the oil phase and stirred for 15 min. (4) High-pressure homogenization: The obtained sample was homogenized three times using a high-pressure homogenizer at 800 bar, and then cooled after discharge to obtain a soluble composition. The composition has a transparent or translucent appearance.

[0060] Comparative Example 1 This comparative example provides a ceramide composition, the formulation of which is shown in Table 3.

[0061] Table 3 Formulation of ceramide compositions

[0062] Comparative Example 2 This comparative example provides a ceramide composition, the formulation of which is shown in Table 4.

[0063] Table 4 Formulation of ceramide compositions

[0064] Experimental Example 1 (1) Pearl type The compositions of experimental groups 1-5 and control groups 1-10 were prepared according to the preparation method of the pearlescent composition provided in Example 3.

[0065] The preparation process of the compositions in control groups 11-13 was roughly the same as that in Example 3, except that: Control group 11: Step (5) was cooled at a rate of 5℃ / min.

[0066] Control group 12: Step (6) isothermal aging omitted.

[0067] Control group 13: Step (6) was kept at 60℃ for 40 min.

[0068] (2) Transparent type The compositions of experimental groups 6-10 and control group 17 were prepared according to the method for preparing transparent compositions provided in Example 4.

[0069] The preparation process of the compositions in control groups 14-16 was roughly the same as that in Example 4, except that: Control group 14: Step (4) homogenized at 6000 rpm for 3 min using a conventional homogenizer.

[0070] Control group 15: Step (4) was homogenized 3 times at 400 bar.

[0071] Control group 16: Step (4) was homogenized 3 times at 1200 bar.

[0072] (3) Detect the products of each group. 1. Appearance and particle size The appearance diagrams of experimental groups 1 and 6 are shown below. Figure 1 and Figure 2 The particle size distribution diagram of the composition in experimental group 6 is shown below. Figure 3 .

[0073] 2. Appearance Characterization – Pearlescent Appearance Score Scoring criteria (out of 10): 10 points: The pearlescent effect is extremely strong, the luster is uniform, and it has a distinct silvery-white metallic luster. Strong flashes can be observed from multiple angles (0°, 30°, 60°). 8-9 points: Strong pearlescent effect, uniform luster, obvious pearlescent appearance, and the pearlescent effect can be clearly observed from multiple angles; 6-7 points: The pearlescent effect is moderate, the luster is relatively uniform, and the pearlescent effect can be observed on the front and at an angle of ≤45°. 4-5 points: The pearlescent effect is weak, and only a slight pearlescent effect can be seen at specific angles; 1-3 points: Basically no pearlescent luster, milky white or semi-transparent in appearance; 0 points: No pearlescent luster, transparent or ordinary emulsion appearance.

[0074] Result determination: The average score of ≥10 reviewers is taken, and the average pearlescent score of the pearlescent composition of the present invention is not less than 8 points.

[0075] Table 5 Appearance Rating

[0076] 3. Stability Test The products from each group were placed in ovens at room temperature, 5°C, and 45°C, and removed after 14 days, one month, two months, and three months. The test results are shown in the table below.

[0077] Table 6 Stability Results

[0078] 4. Skin barrier repair – TEWL test Ten healthy volunteers (aged 18-45 years) were selected to undergo TEWL testing on the inner forearm. The test area was 2×2cm, and the single dose was 10 μL. The concentration of ceramide NP in the product was fixed at 0.1%. The blank sample was only an aqueous base without the addition of ceramide. The test times were 30 min, 60 min, and 2 hours after product use.

[0079] 4.1 Pearl type Table 7 TEWL value after 30 minutes of product use (pearl-type, g / m³) 2 *h)

[0080] Table 8 TEWL value after 60 min of product use (pearl-type, g / m³) 2 *h)

[0081] Table 9 TEWL values ​​after 2 hours of product use (pearl-type, g / m³) 2 *h)

[0082] 4.2 Transparent type Table 10 TEWL value 30 min after product use (transparent type, g / m³) 2 *h)

[0083] Table 11 TEWL value after 60 minutes of product use (transparent type, g / m³) 2 *h)

[0084] Table 12 TEWL value 2 hours after product use (transparent type, g / m³) 2 *h)

[0085] The biomimetic ceramide compositions prepared in this invention (experimental group 1, pearlescent type; experimental group 6, transparent type) exhibited significant skin barrier repair efficacy in paired t-test TEWL tests (n=10 volunteers, NP concentration uniformly 0.1%). The TEWL reduction rates in experimental group 1 at 30 min, 60 min, and 2 h after product use were 10.28%, 15.25%, and 20.92%, respectively; the TEWL reduction rates in experimental group 6 at the three time points were 9.57%, 14.36%, and 21.37%, respectively. Both experimental groups showed highly significant differences relative to the control group at 2 h. P <0.001), and exhibits a time-cumulative characteristic, proving that the composition of the present invention is based on a layered liquid crystal structure that gradually integrates into the intercellular lipid sheet of the stratum corneum to achieve barrier reconstruction.

[0086] In 17 control groups, the necessity of each technical feature of the present invention was demonstrated from four dimensions: ceramide subtype composition (control groups 1-7), auxiliary lipid composition (control groups 8-10), pearlescent preparation process (control groups 11-13), and transparent preparation process (control groups 14-17). Experimental group 1 achieved [the following results] compared to 12 out of 13 pearlescent control groups. P <0.001; the experimental group 6 relative to all 4 transparent control groups reached P <0.001. The above results fully demonstrate that the present invention is irreplaceable and has significant inventiveness in terms of precise subtype ratio (NP:AP:EOP:EOS=10:2.5:1:1), auxiliary lipid combination (phytosterol / behenol / hydrogenated lecithin), and key process parameters (slow cooling + isothermal aging or high pressure homogenization).

[0087] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A composition, characterized in that, Its components include: a mixture of ceramides, phytosterols, behenol, hydrogenated lecithin, alcohols, poloxamer 407, and water; The ceramide mixture comprises ceramide NP, ceramide AP, ceramide EOP and ceramide EOS in a mass ratio of (8~12):(2~3):(0.5~1.5):(0.5~1.5).

2. The composition according to claim 1, characterized in that, The mass ratio of the ceramide mixture, the phytosterols, and the behenol is (2~4):(0.5~1.5):(0.5~1.5).

3. The composition according to claim 1, characterized in that, The composition comprises, by weight, 0.1 to 12 parts of a ceramide mixture, 0.1 to 5 parts of phytosterols, 0.1 to 5 parts of behenol, 1 to 5 parts of hydrogenated lecithin, 10 to 70 parts of alcohols, 0.1 to 7 parts of poloxamer 407, and 20 to 70 parts of water, wherein the alcohols include at least one of butylene glycol and glycerol.

4. The composition according to claim 3, characterized in that, The composition, by weight, comprises: 2.5-12 parts of a ceramide mixture, 0.1-5 parts of phytosterols, 0.1-5 parts of behenol, 1-5 parts of hydrogenated lecithin, 10-40 parts of butylene glycol, 10-30 parts of glycerol, 0.1-2 parts of poloxamer 407, and 20-70 parts of water; or, 0.1-2 parts ceramide mixture, 0.1-5 parts phytosterols, 0.1-5 parts behenol, 1-5 parts hydrogenated lecithin, 10-40 parts butylene glycol, 10-30 parts glycerol, 2-7 parts poloxamer 407 and 20-70 parts water; And / or, the phytosterols are selected from one or more of β-sitosterol, stigmasterol, campesterol, and phytosterol / octyldodecyl lauroyl glutamate.

5. A formulation with skin barrier repair function, characterized in that, It contains the composition according to any one of claims 1 to 4.

6. The method for preparing the formulation with skin barrier repair function as described in claim 5, characterized in that, It includes mixing the composition according to any one of claims 1 to 4.

7. The preparation method according to claim 6, characterized in that, It includes: The oil phase components are mixed and then heated to 80-90°C to dissolve, thereby obtaining the oil phase; the oil phase components include a mixture of ceramides, phytosterols, behenol, hydrogenated lecithin, and butylene glycol; The aqueous phase components are mixed and heated to 80-90°C to obtain an aqueous phase; the aqueous phase components include glycerol, poloxamer 407 and water. The aqueous phase is added to the oil phase for emulsification; The emulsified product was homogenized.

8. The preparation method according to claim 7, characterized in that, The emulsification conditions are 2000~5000 rpm for 5~15 min; And / or, the homogenization is high-speed shearing and / or high-pressure homogenization, wherein the conditions for high-speed shearing are 8000~12000 rpm for 3~5 min, and the conditions for high-pressure homogenization are 600~800 bar for 1~3 times.

9. The preparation method according to any one of claims 6 to 8, characterized in that, After homogenization, the preparation method further includes: Cooling: Cool the homogenized product to a set temperature at a rate of 0.5~2.0℃ / min, where the set temperature is 40~50℃; Isothermal aging: Maintain at the set temperature for 20-40 minutes; Cooling: Cool to room temperature at a rate of 1~5℃ / min.

10. A cosmetic product, characterized in that, It includes the composition according to any one of claims 1 to 4, the formulation according to claim 5, or the formulation prepared by the preparation method according to any one of claims 6 to 9.

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