Traditional Chinese medicine probiotic agent for conditioning human spleen and stomach function and preparation method thereof

Abstract

The application discloses a traditional Chinese medicine probiotic agent with spleen and stomach function regulation and a preparation method thereof. The traditional Chinese medicine probiotic agent is composed of A component oligosaccharide and B component traditional Chinese medicine extract. The probiotic agent is a mixture of microorganisms, such as fermented lactic acid bacteria, plant lactobacillus, animal bifidobacterium, rhamnose lactic acid bacteria, swiss lactic acid bacteria and acidophilic lactobacillus. The traditional Chinese medicine food materials are composed of cassia, red mushroom, golden camellia, pueraria, dried tangerine or orange peel, lemon, vitis lamprochloa, moringa leaf, fig, eucommia ulmoides, cistanche and momordica grosvenorii. The traditional Chinese medicine food material extract and the probiotic agent are synergistically used, the problems of single function, low bioavailability and unsuitability for the internal environment of the human intestinal stomach with cereal as staple food of existing products are effectively solved, the functions of stomach, intestine, spleen, liver, gallbladder and kidney are improved, and a safer and more efficient, more targeted health solution is provided for the people with digestive system function disorder, especially spleen and stomach function disorder.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine probiotic preparations, specifically relating to a traditional Chinese medicine probiotic preparation that regulates the spleen, intestines and stomach functions of the human body and its preparation method. Background Technology

[0002] The human digestive system is a complex physiological system responsible for ingesting, breaking down, and absorbing nutrients and excreting waste. It consists of two main parts: the digestive tract and digestive glands. It maintains life activities through the coordinated action of mechanical and chemical digestion. Clinically, the section from the mouth, pharynx, esophagus, stomach, small intestine, to the duodenum is often referred to as the upper digestive tract, while the jejunum (including the cecum, appendix, colon, and rectum) and the portion below it are called the lower digestive tract. The liver, gallbladder, and pancreas are digestive glands, which are organs that secrete digestive juices. Their secretions flow into the digestive tract to exert their effects; they are divided into small glands located within the walls of the digestive tract and large glands independent of the walls.

[0003] During digestion, salivary amylase in the mouth initiates the initial breakdown of carbohydrates; the stomach, through the synergistic action of gastric acid and pepsin, degrades proteins; the small intestine, as the primary site of digestion and absorption, not only receives various digestive juices such as pancreatic juice and bile, but its abundant villi and microvilli on its mucosal surface greatly increase the absorption area, achieving efficient uptake of nutrients such as proteins, carbohydrates, vitamins, amino acids, and fats. The large intestine is mainly responsible for the reabsorption of water and the formation and temporary storage of feces. The entire system operates in an orderly manner under the regulation of the nervous and humoral systems, while closely interacting with the intestinal microecology. The pancreas, liver, and gallbladder secrete fluids to maintain the growth of beneficial bacteria, jointly maintaining stable digestive function and overall health.

[0004] Therefore, the normal functioning of particularly important organs in the digestive system, such as the gastric glands, intestinal glands, pancreas, liver, and gallbladder, is crucial for the body to physically and chemically digest food taken from the outside world, absorb its nutrients, and expel food residues from the body. This is an important system for ensuring the normal functioning of the body's metabolism.

[0005] With the accelerated pace of modern life, changes in dietary structure, and increased mental stress, digestive system dysfunction and imbalance have become one of the major public health problems affecting public health. Currently, utilizing probiotics, prebiotics, and medicinal and edible ingredients to regulate the digestive system, especially the ecological balance of the gastrointestinal tract and digestive glands, has become an important direction in the research and development of functional foods.

[0006] In existing gastrointestinal conditioning techniques, there are methods using yogurt or some beneficial bacteria as food, and there are also methods using multiple beneficial bacteria and traditional Chinese medicine for conditioning. For example, in 2012, the inventor Hu Hailiang applied for CN201210460746.1, "A Nutritional Liquid for Regulating the Human Digestive System," which is a health product for regulating gastrointestinal function: 1. A method for preparing a nutritional liquid for regulating the human digestive system, characterized in that: the weight percentage of each raw material is: probiotics 2%; natural mineral water 75%; rice bran 2%; spirulina 1%; monk fruit 1%; kudzu root 3%; brown sugar 16%. The preparation method includes: (1) removing impurities from rice bran, spirulina, monk fruit, and kudzu root, crushing them separately, sieving them, and collecting particles that pass through 80 mesh; crushing and sieving brown sugar and collecting particles that pass through 40 mesh; (2) putting the rice bran, spirulina, monk fruit, kudzu root, and brown sugar after sieving in step (1) into a fermentation tank according to the above proportion, adding natural mineral water according to the proportion, stirring until the brown sugar is completely dissolved, adding probiotics according to the proportion, stirring evenly, fermenting in a fully enclosed manner at 35-37℃ for 5 days, filtering, and the filtrate is a nutrient solution that has the function of conditioning and purifying the human digestive tract and blood, and dispensing it into containers; the probiotics are a mixture of Clostridium butyricum, Lactobacillus bulgaricus, Bifidobacterium, Lactobacillus acidophilus, and Streptococcus thermophilus, and their weight ratio is Clostridium butyricum: Lactobacillus bulgaricus: Bifidobacterium: Lactobacillus acidophilus: Streptococcus thermophilus is 1:1:1:1:1. The probiotic flora mentioned uses LABS probiotics produced by Mengniu Company for its yogurt. This product employs a complex probiotic flora including Clostridium butyricum, Lactobacillus bulgaricus, and Bifidobacterium, using natural mineral water as a substrate, and adding rice bran, spirulina, monk fruit, kudzu root, and brown sugar for fermentation, and is used in conjunction with an oligofructose aqueous solution. While the above patent can improve the intestinal flora structure to some extent by supplementing exogenous probiotics, in practical application and in-depth research, the following significant technical limitations have been found: First, the fermentation substrate of Formula B has a relatively simple nutritional structure. Its carbon and nitrogen sources mainly rely on brown sugar, rice bran, and spirulina. Although this can maintain the basic growth and metabolism of probiotics, it lacks complex functional factors that can specifically promote probiotic colonization, proliferation, and repair of the intestinal mucosal barrier. Secondly, the plant-based ingredients in this health supplement (such as kudzu root, wild grape, and monk fruit) directly participate in fermentation. Due to limitations in the fermentation cycle and the differences in the metabolic capacity of the microbial strains, large-molecule active substances (such as polysaccharides and saponins) are difficult to be fully released and converted into small-molecule substances that are easily absorbed by the human body, resulting in low bioavailability of the product. In addition, this health supplement mainly focuses on "supplementing the gut microbiota" and lacks deep targeted intervention for eliminating intestinal inflammation, regulating gastrointestinal motility, and repairing the immune barrier. Its conditioning effect on complex digestive system dysfunctions (such as those accompanied by chronic gastritis, irritable bowel syndrome, or liver, gallbladder, and spleen disorders) is limited.Third, the gut microbiota of Chinese people differs from that of Westerners. Lactose intolerance is common among Asians, while Westerners are more prone to gluten allergies. For example, probiotics like Zhuoyue or those rich in Firmicutes are commonly used in the US and Europe, while Chinese people prefer Proteus. Dietary habits also differ between East and West. Chinese people have a stronger preference for grains, tubers, and vegetables, advocating for a balanced diet of whole grains and vegetables; while Westerners have a higher proportion of meat in their diet. This leads to different health risks in different countries. For instance, lactose intolerance is more common in Asia, while certain metabolic diseases are more prevalent in the West. Fourth, probiotics and the human body have a symbiotic relationship. Over time, regional differences in selection have become particularly pronounced. It is said that different environments nurture different people. Europeans and Americans have long been primarily meat-based, while Easterners have long been primarily grain-based. These two factors have resulted in significant differences in gut microbiota. Many Chinese people have weak spleen and kidneys, and their gut microbiota lacks positive bacteria. Therefore, probiotics adapted to the meat-based diet of Westerners may not be suitable for the grain-based gut microbiota of Chinese people. Fifth, due to differences in diet and environment, the gut microbiota environments of people from the East and West differ significantly. Therefore, imported strains and probiotic blends from abroad may not be suitable for the gut microbiota of Chinese people. We should choose strains with sufficient experimental verification that are more suitable for the gut microbiota environment of Chinese people. Sixth, current technologies using plant-based raw materials (such as kudzu root and monk fruit) are considered to be cold in nature and are not suitable for most people. For example, many traditional Chinese medicine formulas, in order to avoid excessive intake and aggravation of cold and dampness in the body, can neutralize the coldness by combining them with warm ingredients, adjusting cooking methods, or adding seasonings. Seventh, according to five thousand years of Chinese culture, the stomach, intestines, spleen, liver, gallbladder, and kidneys are interconnected. Regulating only the stomach and intestines is not enough. The spleen plays a role in storing blood in the body. When the body has a bleeding disorder, the spleen releases some blood to replenish the body's blood volume. The liver and gallbladder secrete digestive fluids, and the kidneys also filter impurities from the blood and play an immune role. Therefore, when regulating the stomach and intestines, attention should also be paid to the functions of the spleen, liver, gallbladder, and kidneys to stimulate the function of the entire digestive system.

[0007] In conclusion, there are significant differences in gut microbiota between Chinese and Westerners, which are related to their dietary habits, physical constitution, and living environment. Therefore, when choosing traditional Chinese medicine and probiotic products, the localization and origin of the strains should be considered to better adapt to the constitution and gut environment of local people. At the same time, the addition of traditional Chinese herbs can regulate the relationship between the stomach, intestines, spleen, liver, gallbladder, and kidneys, especially the relationship between the stomach, intestines, and spleen, balancing the body's organs and ensuring the normal functioning of the body's metabolism. Summary of the Invention

[0008] To overcome the shortcomings of existing technologies, 1. This invention proposes a traditional Chinese medicine probiotic preparation that regulates the spleen, intestines, and stomach functions. This formula, while retaining the synergistic effect of probiotics and prebiotics, selects probiotic products better suited to the Chinese population, introducing the synergistic effect of compound food-medicine homologous traditional Chinese medicine extracts and highly active probiotics. By combining it with warm-natured ingredients / medicinal herbs, it effectively solves the problems of existing products having limited function, cold constitution, dampness, and low bioavailability, providing a safer, more efficient, more universal, and more targeted health solution for people with spleen and intestine dysfunction. 2. In the field of traditional Chinese medicine, this invention proposes to combine warm-natured ingredients to supplement probiotics while strengthening the regulation of the spleen, stomach, and intestines functions of traditional Chinese medicine, adapting to the digestive systems of various groups of people, including men, women, the elderly, and children, creating a completely new health concept.

[0009] The technical solution of this invention is: The herbal probiotic agent that regulates the human gastrointestinal function is composed of component A and component B. Component A contains fructooligosaccharides, and the weight percentage of fructooligosaccharides is 20-49%. Component B is composed of probiotic agent and extract of food and medicine homology herbal ingredients. The probiotic agent is a mixture of equal weights of fermenting lactic acid bacteria, Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium animalis, Bifidobacterium animalis subsp., Lactobacillus rhamnosus, Lactobacillus helveticus, Bifidobacterium longum, Bifidobacterium breve, Lactobacillus acidophilus, and Lactobacillus reuteri.

[0010] Preferably, the probiotic agent is a mixture of equal weights of Lactobacillus acidophilus NCFM, Lactobacillus fermentum CECT 5716, Lactobacillus helveticus R 0052, Lactobacillus plantarum JYLP-326, Bifidobacterium animalis BB-12, Lactobacillus reuteri DSM 17938, Bifidobacterium longum subsp. longum BB 536, Bifidobacterium longum subsp. infantum M-63, Bifidobacterium longum subsp. infantum R 0033, Bifidobacterium breve M-16V, Lactobacillus plantarum subsp. animalis HM 019, Bifidobacterium animalis subsp. Bi-07, Lactobacillus rhamnosus HN001, Lactobacillus rhamnosus MP 108, Lactobacillus rhamnosus GG (LGG), and Bifidobacterium bifidum R 0071.

[0011] The herbal extract is derived from the following herbal raw materials: cinnamon, red pine fungus, kudzu root, dried tangerine peel, golden camellia flower, lemon, wild grape, moringa leaf, fig, eucommia bark, cistanche, and monk fruit.

[0012] The liquid component of the probiotic agent is 1-3 parts by weight; the traditional Chinese medicine extract is 5-10 parts by weight; and the remainder is purified water or mineral water. The dry weight parts of the aforementioned Chinese medicinal materials are as follows: cinnamon 6-8, red cone fungus 5-8, kudzu root 4-6, dried tangerine peel 3-5, golden camellia flower 2-3, lemon 3-6, wild grape 3-5, moringa leaf 3-5, fig 3-5, eucommia bark 3-5, cistanche deserticola 3-5, and monk fruit 3-5.

[0013] The preparation process of component B described above is as follows: Cinnamon, red pine mushroom, kudzu root, dried tangerine peel, golden camellia flower, lemon, wild grape, moringa leaf, fig, eucommia bark, cistanche, and monk fruit are weighed according to their dry weight, crushed, and placed in a basket. The basket is then placed in an extraction tank, and five times the weight of the medicinal ingredients (food and medicine homology) of purified water is added to the extraction tank. The basket is submerged in the purified water and soaked for 2 hours, then boiled for 3-4 hours. The liquid is filtered out and set aside. The dregs are then boiled again with three times the weight of purified water, filtered, and the filtrates are combined. This combined filtrate is then mixed with probiotics and placed in a fermentation tank. The mixture of probiotics is added at a temperature of 30℃~40℃ and fermented for more than 20 days to obtain component B.

[0014] The method of administration described in this invention is as follows: open the caps of components A and B, pour the liquid from bottle B into bottle A, tighten the cap, shake well, and drink directly within 5 to 30 minutes.

[0015] Component A of this invention contains fructooligosaccharides (FOS), with a weight percentage of 20-49%. FOS is a short-chain carbohydrate naturally found in various plants, belonging to the prebiotic family. It consists of 2 to 4 fructose units and can be produced using glucose and sucrose as substrates. Its development began in the mid-20th century, and with in-depth research into its physiological functions, it has gradually been widely used in the food industry. Because FOS is low in calories and sweetness, it cannot be directly absorbed by the human small intestine, thus having a relatively small impact on blood sugar. Furthermore, it is a non-reducing sugar with strong hygroscopicity, high thermal stability, and is very stable within the general pH range of food products. FOS is widely distributed in natural plants such as bananas, onions, garlic, honey, and Jerusalem artichokes. Fructooligosaccharides are the favorite "nutrients" for "good bacteria" such as Bifidobacteria and Lactobacillus in the colon, selectively promoting the proliferation of these beneficial bacteria. They can also selectively stimulate the proliferation of beneficial bacteria such as Lactobacillus, Lactobacillus plantarum, and Bifidobacterium in the gastrointestinal tract, thereby helping to improve intestinal microecological health. By nourishing beneficial bacteria, they indirectly inhibit the growth of harmful bacteria, thus improving constipation, promoting mineral absorption, and regulating blood lipids. This invention preferentially uses the above-mentioned probiotic agents, including fermented lactic acid bacteria, Lactobacillus plantarum, Bifidobacterium animalis, Bifidobacterium animalis subsp., Lactobacillus rhamnosus, and others. Lactobacillus subtilis, Bifidobacterium longum, Bifidobacterium breve, Lactobacillus acidophilus, and Lactobacillus reuteri can selectively promote the growth and reproduction of beneficial intestinal flora. These probiotics are fermented to produce short-chain fatty acids, which lower the intestinal pH and directly enter the colon for further fermentation. This selectively promotes the proliferation of beneficial bacteria such as Bifidobacterium, regulates the intestinal microecological balance, and has multiple benefits, including improving digestive function and promoting mineral absorption. Therefore, this invention combines probiotic agents and traditional Chinese medicine extracts to better and faster protect the human digestive system, paving the way for better health.

[0016] The following are the specific functions and effects of the various probiotics in this invention: 1. Fermenting lactic acid bacteria generally refer to lactic acid bacteria, a collective term for bacteria that can ferment sugars to produce lactic acid. They are widely distributed in nature and the human gut, and are important probiotic resources. Basic characteristics: Gram-positive bacteria, non-spore-forming, anaerobic or facultative anaerobic, capable of converting carbohydrates into lactic acid. Common applications: Widely used in the production of fermented foods such as yogurt, kimchi, and cheese, helping to improve flavor and shelf life. Health benefits: Studies indicate that consuming fermented foods containing lactic acid bacteria helps regulate gut microbiota, improve digestion, and enhance immunity. The fermenting lactic acid bacteria used in this invention is CECT 5716.

[0017] 2. *Lactobacillus plantarum* is a widely studied probiotic. Its core functions are regulating the balance of intestinal flora, inhibiting harmful bacteria, enhancing intestinal barrier function, and immune regulation. It helps improve intestinal discomfort such as bloating, diarrhea, and constipation, and can also help lower cholesterol and relieve allergies. This strain can also activate immune cells (such as macrophages and T lymphocytes), promote the secretion of immunoglobulin (IgA), and enhance the function of the mucosal immune barrier. Studies have shown that its metabolites may reduce inflammatory responses and lower the risk of respiratory or digestive tract infections by regulating the expression of immune factors. After comparison, this invention selects *Lactobacillus plantarum* jylp-326.

[0018] 3. Bifidobacterium animalis and its subspecies; Bifidobacterium animalis belongs to the phylum Actinobacteria. (actinobacteria) These are beneficial probiotics for the gut, with functions including regulating gut microbiota, enhancing immunity, and promoting nutrient absorption. Specific strains show significant effects in improving digestion and immune protection. Their functions include: 1. Regulating gut microbiota balance: inhibiting the growth of harmful bacteria, maintaining gut microecological balance, and improving constipation and diarrhea symptoms; 2. Optimizing gut function: shortening intestinal transit time, increasing defecation frequency, improving stool characteristics, and alleviating discomfort caused by lactose intolerance; 3. Enhancing the immune barrier: stimulating the production of immune cells, promoting immunoglobulin A secretion, and enhancing the intestinal mucosal barrier function; 4. Reducing the risk of infection. This invention preferably uses *Bifidobacterium animalis* BB12 and *Bifidobacterium animalis* subspecies HM019.

[0019] 4. Lactobacillus rhamnosus primarily works by regulating intestinal flora balance, enhancing immunity, and alleviating allergic reactions. Its effects include: 1. Improving diarrhea or constipation, reducing infection risk, and assisting in the relief of eczema, with a high safety profile, making it suitable as a health supplement for specific populations; 2. Regulating intestinal flora and digestive health. Lactobacillus rhamnosus can colonize the intestinal mucosa, inhibiting the excessive proliferation of harmful bacteria (such as Escherichia coli and Salmonella), promoting the growth of beneficial bacteria, and maintaining intestinal microecological balance. Clinical studies show that it has a significant effect on improving antibiotic-associated diarrhea and traveler's diarrhea, while also relieving indigestion symptoms such as constipation and bloating. Furthermore, this bacterium can break down indigestible carbohydrates in food, producing short-chain fatty acids to provide energy for intestinal cells. This invention uses several types of Lactobacillus rhamnosus, including: Lactobacillus rhamnosus HN 001, Lactobacillus rhamnosus MP 108, and Lactobacillus rhamnosus GG (LGG).

[0020] 5. Helvetica lactic acid bacteria, Lactobacillus helvetica (Lactobacillus helveticus)Lactobacillus repens fermented milk contains various bioactive peptides that enhance human metabolism, promote immunity, act as hormones, inhibit enzymes, and have antibacterial, antiviral, and lipid-lowering effects. The proteases secreted by Lactobacillus repens release the bioactive peptides from the porin in dairy products, resulting in peptides that have antihypertensive, tumor-inhibiting, and cholesterol-lowering effects. It can effectively lower blood pressure while also relieving hypertension, reducing tension, improving brain function, and enhancing memory and learning abilities. Furthermore, Lactobacillus repens fermented milk also contains casein phosphopeptides (CPPs), which promote the absorption of elements such as calcium and iron.

[0021] 6. Both Bifidobacterium breve and Bifidobacterium longum are beneficial gut bacteria, but they differ in their primary distribution populations and functional focuses: Bifidobacterium breve is more specialized in utilizing human milk oligosaccharides and is a "pioneer bacterium" in the infant gut; Bifidobacterium longum remains dominant in adulthood and is widely involved in various metabolic support processes; Classification and nomenclature: Bifidobacterium breve (Bifidobacterium breve) Bifidobacterium longum (Bifidobacterium longum) These are two independent species within the genus *Bifidobacterium*, not simply differences in length between the same bacterium. Their origins and main distribution characteristics are as follows: *Bifidobacterium breve*: Naturally colonizes the intestines of breastfed infants, a key member of the early gut microbiota, efficiently breaking down oligosaccharides in breast milk and helping to establish a healthy gut environment. *Bifidobacterium longum*: Detectable in both infant and adult intestines, one of the most common bifidobacteria in adults, and widely found in traditional fermented foods, exhibiting stronger adaptability. Regarding their functions and applicable scenarios: *Bifidobacterium breve*: Primarily involved in infant immune development and the establishment of the intestinal barrier, with substantial research support for preventing infant diarrhea and alleviating allergies. *Bifidobacterium longum*: In addition to maintaining gut microecological balance, it is also associated with reducing constipation, alleviating symptoms of irritable bowel syndrome in adults, and improving lactose intolerance. Some strains can also help regulate anxiety, making its application range broader. In practical considerations, when supplementing infants with probiotics, formulas containing *Bifidobacterium breve* are often preferred because they are more compatible with the infant's gut environment. Products containing Bifidobacterium longum are more commonly used by adults for daily conditioning or dealing with digestive problems, but this is not absolute; the specific effect depends on the strain and individual differences. The two are not mutually exclusive; many products use them together to achieve a synergistic effect. Therefore, this invention uses Bifidobacterium breve M-16 for infants and Bifidobacterium longum BB536 for adults.

[0022] 7. Lactobacillus acidophilus (Lactobacillus acidophilus, Abbreviated as A) and Bifidobacterium lactis (Bifidobacterium,(B) A fermentation agent composed of these two live bacteria. Consuming dairy products containing these two live bacteria is beneficial to the digestive system, especially for infants with gastrointestinal dysfunction and patients with gastrointestinal dysfunction caused by long-term oral antibiotics. After consuming fermented milk containing these two live bacteria, the intestinal flora can quickly return to normal balance, inhibiting the proliferation of putrefactive bacteria, thus having excellent nutritional and health benefits. Lactobacillus acidophilus is an important probiotic naturally present in the human gut and oral cavity, belonging to the lactic acid bacteria family. It inhibits the growth of harmful bacteria by producing lactic acid and is one of the "main forces" in maintaining the balance of the intestinal microecology, often added to yogurt and probiotic supplements. Its functions and health benefits include: 1. Regulating the intestinal microecology: Lactobacillus acidophilus can metabolize and produce substances such as lactic acid and hydrogen peroxide, making the intestinal environment acidic. This acidic environment can inhibit the reproduction of putrefactive bacteria and pathogenic bacteria such as Salmonella and Escherichia coli, thereby improving diarrhea and indigestion. 2. Assisting in improving lactose intolerance: This bacterium can secrete lactase, which can help break down lactose in milk. For people who experience bloating and diarrhea after drinking milk, consuming Lactobacillus acidophilus or yogurt fermented with it can help alleviate these symptoms. 3. Supports immune and vaginal health: It can colonize the intestinal mucosa and urogenital tract, helping to resist pathogen invasion through competitive site selection and secretion of antibacterial substances, thus playing a positive role in reducing the risk of intestinal infections and bacterial vaginosis. This invention uses Lactobacillus acidophilus NCFM.

[0023] 8. Lactobacillus reuteri, Lactobacillus reuteri (Lactobacillus reuteri) Lactobacillus reuteri is a probiotic widely found in the intestines of humans and animals, possessing multiple functions including regulating gut microbiota balance, enhancing immunity, inhibiting pathogenic bacterial growth, and alleviating inflammation. Its unique metabolites (such as reuterin) can directly or indirectly affect host health, offering potential benefits to the gut, immune system, skin, and even metabolic-related diseases. 1. Gut health regulation: Lactobacillus reuteri maintains gut microecological balance by competitively inhibiting the colonization of harmful bacteria and promoting the production of short-chain fatty acids (such as acetic acid and propionic acid). It can improve symptoms such as diarrhea, constipation, and irritable bowel syndrome (IBS), and may reduce the risk of intestinal inflammation (such as ulcerative colitis). Studies have also shown that this bacterium can repair intestinal barrier function, reducing "leaky gut" and thus lowering the risk of toxins entering the bloodstream. 2. Immune system support: Lactobacillus reuteri can activate gut-associated lymphoid tissue (GALT) and enhance the activity of immune cells. Its secreted metabolites can regulate immune responses, such as inhibiting the release of pro-inflammatory factors (e.g., TNF-α, IL-6) while promoting the production of anti-inflammatory factors (e.g., IL-10). Clinical studies have shown that supplementation with this bacterium may reduce the frequency of respiratory infections and has a certain allergic effect on allergic diseases (e.g., eczema, rhinitis). This invention uses Lactobacillus reuteri DSM17938.

[0024] The probiotics and traditional Chinese medicine extracts selected in this invention have good compatibility. For example, the principal herbs (cinnamon and red cone bacteria) have shown good reproductive capacity after being added to the probiotic composition. After adding the assistant herbs, adjuvant herbs, and guiding herbs such as Camellia chrysantha flowers, lemon, Cistanche deserticola, Moringa leaves, fig, Eucommia ulmoides, and Siraitia grosvenorii, no decrease in the number of bacteria was found during fermentation in solution.

[0025] The liquid component of the probiotic agent is 1-3 parts by weight; the extract of food and medicine homology traditional Chinese medicine ingredients is 5-10 parts by weight; the remainder is purified water or mineral water. The dry matter weight parts of the aforementioned food and medicine homology Chinese herbal ingredients extract are as follows: cinnamon 6-8, red cone fungus 5-8, kudzu root 4-6, dried tangerine peel 3-5, golden camellia flower 2-3, lemon 3-6, wild grape 3-5, moringa leaf 3-5, fig 3-5, eucommia bark 3-5, cistanche deserticola 3-5, and monk fruit 3-5.

[0026] The following are the efficacy and effects of the food-medicine homology traditional Chinese medicine of this invention: 1. Cinnamon, Latin name: Cinnamomum cassia Presl. Other names: Cinnamon, Cassia bark, Cinnamon bark; refers to the cinnamon plant (Cinnamomum cassia) of the Lauraceae family. Cinnamomum cassia Presl. The dried bark of cinnamon is mostly harvested in autumn and dried in the shade. The outer layer of cinnamon bark is brown and relatively rough, while the inner layer is reddish-brown and oily, with a yellowish-brown line between the two layers. It has a strong aroma and a sweet and spicy taste. Currently, cinnamon is mainly used as a spice. Its main functions and effects are to replenish qi and yang, nourish qi and blood, calm the mind and soothe the nerves, warm and tonify the yang of the spleen and kidneys, and dispel cold from the spleen and stomach. It can prevent other cold-natured medicines (such as golden camellia and wild grape) from harming the stomach, promote blood circulation, and relieve abdominal pain and indigestion caused by stomach cold; cinnamon can help dilate blood vessels, promote blood circulation throughout the body, and improve blood supply to the heart and brain; reduce fever and convulsions; promote intestinal peristalsis and improve digestive function; relieve pain caused by stomach spasms, protect the gastric mucosa and prevent ulcers; help control blood sugar levels and inhibit bacterial growth. Note that cinnamon specifically refers to the inner bark of the cinnamon tree, a plant in the Lauraceae family. Some people also refer to the bark of other Lauraceae plants such as cinnamon bark, cinnamon tung oil, and cinnamon bark as cinnamon bark. Usually, this refers to the two species that are different from each other, even though they belong to the same genus.

[0027] 2. Conophytum rubrum, Latin name Russula vinosa,It is a rare wild edible fungus that grows symbiotically under the red pine forest, and is only distributed in a few red soil hilly areas such as Guangxi and Guangdong. Red pine mushroom is a purely natural wild edible fungus, commonly known as "red mushroom." Not only is it delicious, but it is also considered a health-preserving delicacy. Rich in polysaccharides and iron, it mainly has the effects of nourishing yin and kidneys, promoting blood circulation and removing blood stasis, and nourishing blood and beautifying the complexion. It has a good auxiliary effect on improving anemia and enhancing immunity. Red pine mushroom is rich in a variety of essential nutrients: high-quality amino acids and polysaccharides: it contains a variety of amino acids and fungal polysaccharides that the human body cannot synthesize on its own. These substances are key raw materials for enhancing physical fitness and repairing cells. Abundant minerals: especially high levels of trace elements such as iron and zinc, among which natural organic iron has a positive promoting effect on hematopoiesis. Vitamins: it contains B vitamins, which help maintain the health of the nervous system and relieve fatigue. In addition, red pine bacteria are very beneficial to women and may be associated with lactation. They are rich in a variety of nutrients: red pine bacteria contain protein, iron, B vitamins, etc., which are the basic nutrients needed for postpartum recovery.

[0028] 3. Kudzu root (Latin name) :Pueraria lobata (Willd.) Ohwi or Pueraria thomsonii Benth. Other names: Kudzu root, sweet kudzu, kudzu vine, dried kudzu, kudzu hemp vine. Kudzu root is a popular ingredient in soups in southern China. Wild kudzu grows abundantly in the mountains of Guangdong, Guangxi, Hunan, and Hainan, and many people cultivate improved varieties around their homes. Its main effects and functions are: promoting yang and relieving muscle tension, relieving rashes and diarrhea, and calming irritability and reducing fever. Value: Kudzu root is rich in flavonoids (such as puerarin), which can improve microcirculation. In gastrointestinal regulation, it is rich in dietary fiber, which absorbs a large amount of toxins in the intestines, and has an auxiliary therapeutic effect on diarrhea caused by spleen deficiency. It can also detoxify alcohol, protect the gastric mucosa, and promote bowel movements.

[0029] 4. Dried tangerine peel (Latin name) Citrus Reticulata Pericarp Orange peel, also known as: tangerine peel, Guilao, yellow tangerine peel, red peel, orange peel, Guangju peel, Chenju peel, Xinhui peel; has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It can be used to treat symptoms such as spleen and stomach qi stagnation, vomiting, cough with excessive phlegm, etc., and also has certain effects on the digestive system, cardiovascular system, and respiratory system. Classical medicinal descriptions include: The *Shennong Bencao Jing* records: "It treats chest fullness and heat, rebellious qi, promotes urination and digestion, and with prolonged use, removes foul odor and lowers qi." The *Bencao Gangmu* records: "It treats vomiting, nausea, frequent vomiting of clear water, phlegm accumulation, cough, malaria, constipation, and mastitis in women. When added to food, it detoxifies fish poisoning." It also points out that "its ability to treat various diseases is mainly due to its qi-regulating and dampness-drying effects." The *Mingyi Bielu* records: "It treats qi stagnation, stops vomiting and coughing, treats qi rushing to the chest, vomiting, cholera, spleen inability to digest food, and stops diarrhea."

[0030] The main effects and functions of dried tangerine peel: Regulating Qi and strengthening the spleen: Dried tangerine peel can relieve symptoms such as abdominal distension, belching, and nausea caused by stagnation of Qi in the spleen and stomach, and improve the digestive function of the spleen and stomach. Drying dampness and resolving phlegm: Dried tangerine peel can dry dampness and resolve phlegm, suitable for coughs with cold phlegm and damp phlegm, making phlegm easier to cough up, and has a slight bronchodilatory effect. Promoting digestion: The volatile oil contained in dried tangerine peel has a mild stimulating effect on the gastrointestinal tract, can promote the secretion of digestive juices, eliminate or expel gas in the intestines, and has a fragrant stomachic and wind-dispelling effect. Other effects: Dried tangerine peel also has expectorant, antitussive, antiasthmatic, myocardial stimulant, mild vasoconstrictor, blood pressure raising, prevention of arteriosclerosis caused by a high-fat diet, inhibition of common pathogenic bacteria such as Staphylococcus aureus, coronary artery dilation, and improvement of myocardial blood supply.

[0031] 5. The golden camellia flower is a plant endemic to Fangchenggang and Nanning cities in Guangxi. It is considered a giant panda in the plant kingdom. The Latin name for golden camellia is... :Camellia nitidissima, Other names: Queen of the Tea Clan, Multi-petaled Yellow Camellia, Golden Flower. Main effects and functions of Golden Camellia flowers: Clearing heat and detoxifying, promoting diuresis and reducing swelling, lowering blood lipids, and lowering blood sugar. Value: Its flowers contain natural pigments, tea polyphenols, and various amino acids, which can enhance the body's immunity, have significant effects on anti-oxidation and regulating human metabolism, and help improve the intestinal inflammatory environment. Active ingredients: Flavonoids: High in Golden Camellia flowers, these are important antioxidants that help eliminate free radicals in the body and reduce oxidative damage. Golden Camellia flowers are rich in tea polyphenols and tea polysaccharides: These two components have been extensively studied in regulating blood lipids and helping to lower blood sugar; they can slow down sugar absorption and improve insulin sensitivity. It also contains natural minerals and trace elements: selenium, germanium, zinc, etc., which are helpful in maintaining immune function and metabolic health. Main effects and functions: (1) Antioxidant and anti-aging: Flavonoids and tea polyphenols can resist cell oxidation, protect blood vessel elasticity, and have certain benefits for skin and cardiovascular health. (2) Assist in regulating blood sugar: Tea polysaccharides can help stabilize postprandial blood sugar. Some experiments have shown that they have an improving effect on insulin resistance and are suitable for daily diet. (3) Assist in regulating blood lipids: It helps to lower cholesterol and triglycerides and has a positive effect on preventing atherosclerosis, but it still needs to be combined with a balanced diet and exercise. (4) Enhance immunity: Trace elements and antioxidants work together to support the function of the immune system, reduce inflammatory response, and help the body resist external damage.

[0032] 6. Lemon, Latin name :Citrus limon (L.) Burm. f.Other names: lemon, mother lemon, foreign lemon. Main effects and functions of lemon: quench thirst, stimulate appetite and digestion, resolve phlegm and relieve cough. Value: rich in citric acid and vitamin C, which can promote the secretion of pepsin, help digestion and relieve loss of appetite. Its sour taste can astringe and promote saliva production, and balance the sweetness of other ingredients in the formula. Lemon probiotics are a product that combines probiotics with lemon extract. Its core function is to regulate the balance of intestinal flora, promote digestion, and supplement vitamin C. Simply put, it focuses on the dual effects of "intestinal health" and "nutritional supplementation", which is suitable for improving digestive discomfort and enhancing daily immunity. The inventor believes that the effects of lemon and probiotics are: (1) intestinal digestion and flora regulation. Probiotics are the key active ingredients and mainly act on the intestines; (2) balance microecology: supplementing beneficial bacteria can inhibit the reproduction of harmful bacteria, maintain the balance of intestinal flora, and improve bloating, diarrhea or constipation caused by flora imbalance. Promote digestion and absorption: Probiotics can help break down food, help generate digestive enzymes, relieve indigestion, and promote the absorption of nutrients; (3) Nutritional support and body protection; (4) Freshen the mouth and assist in purification.

[0033] 7. Wild grape, Latin name: Amur grape Rupr. Other names: Wild grape, wild grape, cat's eye, mountain grape. This variety grows naturally on rocky mountains in several counties of Guangxi, including Hechi, Nanning, Du'an, Mashan, and Luocheng. Its main effects and uses include: clearing heat and detoxifying, dispelling wind and dampness, promoting diuresis and reducing swelling, and relieving pain. Value: It has significant anti-inflammatory and antibacterial effects, and can clear damp-heat toxins from the intestines. It is often used to treat dysentery and enteritis (as recorded in *Jiangxi Folk Herbal Medicine*, wild grape can treat dysentery).

[0034] 8. Moringa leaves, Latin name: Moringa oleifera Lam. Other names: Drumstick leaves, Miracle Tree Miracle Tree Moringa leaves are mainly produced in Yunnan, Guangdong, Guangxi, Hainan, and Fujian provinces in China, with Yunnan being the primary growing region. Its main effects and benefits include lowering blood sugar and cholesterol, detoxifying and beautifying the skin, and boosting immunity. Value: Known as a "complete nutrient," it is rich in protein, vitamins, and minerals. Its high fiber content helps with bowel movements, promotes intestinal peristalsis, and improves constipation.

[0035] 9. Fig, Latin name: Ficus carica L. Other names: Sun-reflecting fruit, Honey fruit, Fairy fruit, Milk fruit, Tree sweet potato. Main effects and functions: Strengthens the stomach and intestines, reduces swelling and detoxifies, soothes the throat. Value: Figs contain malic acid, citric acid, lipase, etc., which can aid digestion and treat loss of appetite and indigestion. Its rich enzyme content helps "regulate the intestines and strengthen the stomach," and has auxiliary therapeutic effects on chronic enteritis and dysentery.

[0036] 10. Eucommia ulmoides, Latin name: Eucommia ulmoides OlEucommiae Cortex.Eucommia bark, also known as: Sixian, Sizhong, Mian, Yusipi, Chesipi, Simianpi, Chuan Duzhong, Han Duzhong. Main effects and functions: Functions: Heart function: Tonifies the liver and kidneys, strengthens tendons and bones, and calms the fetus; Value: Powerful strengthening effect: This invention uses Eucommia bark, a traditional kidney-tonifying medicine, whose liver- and kidney-tonifying effects are stronger than Eucommia leaves. In the formula, it can play a stronger "strengthening and consolidating" role, improving intestinal motility deficiency caused by kidney deficiency. Synergistic effect: Eucommia bark is rich in active ingredients such as Eucommia gum, chlorogenic acid, and genipin, which have strong antioxidant and metabolic regulating capabilities. It can synergistically work with warming herbs such as cinnamon and Cistanche deserticola in the formula to further enhance the overall constitution of the body and provide a robust internal environment for the colonization of probiotics.

[0037] 11. Cistanche deserticola, Latin name: Cistanche deserticola YC Ma Other names: Cistanche deserticola, Cunyun, Dan Dayun. Main effects and functions: Core function: Tonifies kidney yang, nourishes essence and blood, moistens the intestines and promotes bowel movement. Value: Cistanche deserticola is a good medicine for warming and tonifying kidney yang. It has a soft and moist texture and contains galactitol and other components, which can significantly improve intestinal lubrication and promote defecation. It is especially suitable for habitual constipation (yang deficiency constipation) in the elderly or those with weak constitution.

[0038] 12. Monk fruit, Latin name: Siraitia grosvenorii (Swingle) C. Jeffrey ex AM Lu and ZY Zhang, Other names: Monk fruit, false bitter melon, glossy ginkgo. Origin: Yongfu County, Guilin City, Guangxi Province, etc. Main effects and functions: Clears heat and moistens the lungs, soothes the throat and improves voice, lubricates the intestines and promotes bowel movements. Value: Monk fruit glycosides are a non-sugar sweetener, hundreds of times sweeter than sucrose, but they do not cause blood sugar fluctuations, making them suitable for diabetics. Its "laxative" effect helps relieve constipation and clears lung heat (the lungs and large intestine are internally and externally related), aiding in intestinal detoxification.

[0039] This invention originates from the theories of traditional Chinese medicine spanning thousands of years. Through pharmaceutical and formulation research, and based on traditional medicine, it analyzes the properties of the aforementioned Chinese herbs using the principles of monarch, minister, assistant, and guide. The monarch-minister-assistant-guide principle is a fundamental principle in the composition of traditional Chinese medicine prescriptions, classifying drugs into four levels: monarch, minister, assistant, and guide drugs, each with a different status and function in the prescription.

[0040] Monarch drug: a drug that plays a major therapeutic role in the main disease or main syndrome, is the core of the prescription, and its medicinal power ranks first in the prescription. In addition to the above bacterial strains, the traditional Chinese medicine of the present invention uses cinnamon and *Russula vinosa* as the monarch drugs of the prescription. Because cinnamon's main efficacy and function are that it is a qi-tonifying and yang-elevating drug, which can tonify qi and enrich blood, nourish the heart and calm the mind, warm and tonify the yang of spleen and kidney, dispel cold qi in spleen and stomach, prevent other cold-natured drugs (such as camellia chrysantha flower, amur grape, pueraria, etc.) from injuring the stomach, promote blood circulation, and relieve abdominal pain and indigestion caused by stomach cold; cinnamon can help dilate blood vessels, promote systemic blood circulation, and improve blood supply to the heart and brain; reduce fever and reduce convulsions; promote intestinal peristalsis and improve digestive function; relieve pain caused by gastric spasm, protect gastric mucosa and prevent ulcers; assist in controlling blood glucose level and inhibit bacterial growth; it is reported that cinnamon has a strong anti-inflammatory effect, because cinnamaldehyde in cinnamon can inhibit the activity of an enzyme called COX-2 in the human body, which is similar to the mechanism of some anti-inflammatory analgesics, and its effect is relatively mild. *Russula vinosa* mainly has the efficacies of nourishing yin and tonifying kidney, activating blood circulation to remove blood stasis, enriching blood and beautifying, and has a good auxiliary effect on improving anemia and enhancing immunity. *Russula vinosa* is rich in a variety of essential nutrients for human body: it contains high-quality amino acids and polysaccharides, including a variety of amino acids and fungal polysaccharides that the human body cannot synthesize by itself, and these substances are key raw materials for enhancing physique and repairing cells. The selection of cinnamon and *Russula vinosa* makes the probiotic product better adapted to Chinese people, so that the product can better adapt to the physique and intestinal environment of local people by introducing the synergistic effect of compound medicinal and edible homologous traditional Chinese medicine extract and highly active probiotics. Through the combination of warm-natured food / herbs, the problems of single function, cold and damp constitution and low bioavailability of existing products are effectively solved, and a safer, more efficient, more universal and more targeted health solution is provided for people with gastrointestinal dysfunction.

[0041] This invention selects dried tangerine peel and golden camellia flowers as auxiliary ingredients: to assist the principal ingredient in enhancing efficacy, and can have multiple functions, such as directly participating in the treatment of the main disease or symptom; reducing or eliminating the potential toxic side effects of the principal ingredient; and treating concurrent diseases or symptoms. Because the volatile oils contained in dried tangerine peel have a mild stimulating effect on the gastrointestinal tract, it can promote the secretion of digestive juices, inhibit common pathogenic bacteria such as Staphylococcus aureus, eliminate or expel gas in the intestines, and has a fragrant stomach-strengthening and wind-dispelling effect, relieving symptoms such as abdominal distension, belching, and nausea caused by spleen and stomach qi stagnation, and improving the spleen and stomach's digestive function. It promotes digestion and also has expectorant, antitussive, antiasthmatic, myocardial stimulant, mild vasoconstrictor, and blood pressure-raising effects. Golden camellia flowers contain natural pigments, tea polyphenols, and various amino acids, which can enhance the body's immunity, have significant effects on antioxidation and regulating human metabolism, and help improve the intestinal inflammatory environment. Active ingredients: Flavonoids, important antioxidant components, help to eliminate free radicals in the body and reduce oxidative damage. Golden camellia flowers are also rich in tea polyphenols and tea polysaccharides, which help improve the intestinal inflammatory environment. Therefore, they are very beneficial to the digestive system. Drinking a combination of dried tangerine peel and golden camellia flowers can exert a synergistic effect of regulating qi and strengthening the spleen, clearing heat and dampness, and promoting body fluid production and moisturizing dryness. It is especially suitable for people who experience dry mouth and throat, loss of appetite, or damp heat in the body. The two are warming and cooling, respectively, harmonizing each other and making the combination more mild, suitable for daily health maintenance. Combining dried tangerine peel and golden camellia flowers can leverage their combined advantages in the following aspects: 1. Synergistic effects: moisturizing the lungs and throat, relieving autumn dryness. Golden camellia flowers are rich in natural flavonoids and polysaccharides, which can moisturize the throat and relieve dry mouth and tongue. Dried tangerine peel contains volatile oils, which can regulate qi and resolve phlegm, making breathing feel smoother, and is especially suitable for throat discomfort and mild cough caused by dryness; 2. Awakening the spleen and stomach, relieving stagnation. Dried tangerine peel is a classic "spleen and lung medicine," adept at regulating qi and resolving dampness, and can effectively relieve abdominal distension and indigestion. Some people combine the delicate sweetness of golden camellia flowers with the aroma of dried tangerine peel to awaken the taste buds. Drinking it after meals helps reduce greasiness and stomach burden. 3. It harmonizes both sides, stabilizing emotions. Golden camellia flowers themselves have a calming and soothing effect, while the fragrance of dried tangerine peel can soothe liver qi. When facing stress, emotional instability, or restlessness, the aroma of this tea helps to relax and stabilize the mind.

[0042] This invention selects Moringa leaves, figs, Eucommia ulmoides, and Cistanche deserticola as adjuvant herbs. This serves three purposes: first, as adjuvant herbs, they assist the principal and assistant herbs in achieving greater therapeutic effects; second, as counteracting adjuvant herbs, they have properties opposite to the principal and assistant herbs, restraining their biases and preventing excessive heat from harming the body's vital energy or causing adverse reactions; third, as guiding herbs, they direct other herbs directly to the affected area. This invention utilizes two main medicinal ingredients: first, a guiding agent that directs the other herbs in the formula directly to the affected area; and second, a harmonizing agent that enhances flavor and aroma, enabling the herbs to work synergistically to expel pathogens. This invention uses lemon, wild grape, and monk fruit as guiding ingredients, giving the herbal decoction the properties of wild grape—its thirst-quenching, digestive, and sweet-sour flavor, rich in juice—which can quench thirst, improve appetite, and alleviate dry mouth and loss of appetite. Simultaneously, wild grape is rich in vitamins, minerals, water, sugar, amino acids, and other nutrients, providing the refreshing taste of lemon, regulating intestinal pH, and helping to replenish the body's nutritional needs, while also offering the sweetness of monk fruit to reduce the bitterness of the herbal decoction or adjust its flavor.

[0043] The production method of the health product for regulating gastrointestinal function of the present invention is as follows: (1) Use commercially available fructooligosaccharide products directly as component A.

[0044] (2) The preparation process of component B is as follows: Cinnamon, red pine fungus, kudzu root, dried tangerine peel, golden camellia flower, lemon, wild grape, moringa leaf, fig, eucommia, cistanche, and monk fruit are weighed according to dry weight, crushed and placed in a basket, and the basket is placed in an extraction tank. Five times the weight of the food and medicine homology Chinese medicinal materials are added to the extraction tank, and the basket is submerged in the purified water. Soak for 2 hours, then boil for 3-4 hours, and filter out the liquid for later use. The dregs are boiled with three times the amount of water, filtered and combined with the filtrate. Then, the filtrate is combined with the probiotic group and placed in a fermentation tank. At a temperature of 30℃~40℃, the probiotic mixture is added and fermented for more than 20 days to obtain component B.

[0045] In component B, the liquid portion of probiotics is 1-3 parts by weight; the extract of food and medicine homology traditional Chinese medicine ingredients is 5-10 parts by weight; the remainder is purified water or mineral water. (3) Package components A and B to obtain the product. (For ease of carrying and use, the product volumes in the two bottles A and B are proportional.)

[0046] The method of administration is as follows: Open the caps of components A and B, pour the liquid from bottle B into bottle A, tighten the cap, shake well, and drink directly within 5 to 30 minutes.

[0047] The advantages of this invention are: Compared with the prior art (the patented technology previously obtained by the inventor), This invention uses fructooligosaccharides as component A, combined with the herbal extracts of this invention, to provide beneficial intestinal bacteria with an efficient carbon source and energy. Component B, consisting of cinnamon, red pine mushroom, kudzu root, tangerine peel, golden camellia flower, lemon, wild grape, moringa leaf, fig, eucommia, cistanche, and monk fruit, is rich in active substances such as alkaloids, polysaccharides, vitamins, amino acids, and volatile oils. These herbs not only adapt to probiotics, regulate gastrointestinal pH, and promote digestive juice secretion, but also have significant antibacterial, anti-inflammatory, and immunomodulatory effects.

[0048] This invention utilizes cinnamon and *Pleurotus erythrorhizon* to help dilate blood vessels, promote systemic blood circulation, and improve blood supply to the heart and brain; it also has the effects of nourishing yin and kidneys, promoting blood circulation and removing blood stasis, and nourishing blood and beautifying the complexion; it reduces fever, promotes intestinal peristalsis, and improves digestive function; it relieves pain caused by stomach spasms, protects the gastric mucosa to prevent ulcers, helps control blood sugar levels, and inhibits bacterial growth; it has a good auxiliary effect on improving anemia and enhancing immunity. The herbal extract is rich in a variety of essential nutrients for the human body; it is a probiotic product better suited for Chinese people, containing high-quality amino acids and polysaccharides; it is adapted to the constitution and intestinal environment of local people, introducing the synergistic effect of compound food and medicine homology herbal extracts and highly active probiotics; by combining with warm ingredients / medicinal materials, it rationally utilizes various ingredients to improve the taste of the beverage, effectively solving the problems of single function, cold and damp constitution, and low bioavailability of existing products; it contains a variety of amino acids and fungal polysaccharides that the human body cannot synthesize on its own, which are key raw materials for enhancing physical fitness and repairing cells.

[0049] The active ingredients in the herbal extract of this invention can better improve the digestive system and enhance the intestinal barrier function, creating favorable conditions for the colonization and reproduction of probiotics. In turn, probiotics can metabolize and transform the components of food-medicine homologous herbs, enhancing their bioavailability and efficacy. This "bacteria-medicine symbiosis" model significantly improves the product's comprehensive regulatory ability on the spleen, stomach, and intestinal function.

[0050] The food-medicine homology compound of this invention targets multiple pathological aspects of spleen, stomach and intestinal dysfunction (such as dysbiosis, mucosal damage and immune imbalance) for multi-target intervention. Compared with the single nutritional supplementation mode in the prior art, it has a clearer therapeutic direction and more significant clinical effect, and the improvement reaction unique to food-medicine homology is stronger.

[0051] This invention, by optimizing the component structure and introducing a new synergistic mechanism of food and medicine homology, demonstrates significant advantages in improving product stability, enhancing bioavailability, and improving gastrointestinal health, and has broad application prospects.

[0052] This invention incorporates novel food-medicine homologous Chinese herbal ingredients and probiotics in a specific ratio, then ferments them at room temperature (30-40℃) for over 20 days. In addition to the original microbial flora, the food-medicine homologous Chinese herbal ingredients also introduce a significant amount of yeast and lactic acid bacteria, promoting better fermentation. Its advantages over existing technologies lie in utilizing the unique properties of cinnamon, red pine mushroom, dried tangerine peel, golden camellia, kudzu root, lemon, wild grape, moringa leaves, fig, eucommia, cistanche, and monk fruit. It is rich in flavonoids, polysaccharides, volatile oils, polyphenols, triterpenoids, and other compounds, which can improve microcirculation. In gastrointestinal regulation, it can "raise yang and stop diarrhea," providing adjunctive treatment for diarrhea caused by spleen deficiency. It also detoxifies alcohol, protects the gastric mucosa, promotes saliva production and quenches thirst, stimulates appetite and digestion, and resolves phlegm and relieves cough. Furthermore, its high citric acid and vitamin C content promotes pepsin secretion, aids digestion, and alleviates loss of appetite. Its sour taste can astringe and promote salivation, balancing the sweetness of other ingredients in the formula. It has significant anti-inflammatory and antibacterial effects, and can clear damp-heat toxins in the intestines. Even those suffering from dysentery and enteritis can recover quickly.

[0053] Overall effect: 1. The components of the compound food and medicine homology traditional Chinese medicine ingredients of the present invention work synergistically and complement each other, and have antibacterial, anti-inflammatory, antiviral, and antibacterial endotoxin effects, and can rapidly and effectively improve symptoms, with significant effects.

[0054] 2. The food and medicinal ingredients in this formula are abundant, inexpensive, and easy to process, which is conducive to market promotion.

[0055] 3. The above-mentioned food-medicine homology Chinese herbal ingredients work together to inhibit pathogens, clear stagnation, and protect the stomach, spleen, liver, and kidneys. They have a good therapeutic effect on digestive system inflammation. After several years of continuous accumulation of experiments with more than 300 volunteers, it has been found that regardless of gender or age, they can detoxify, reduce inflammation, relieve pain, and restore gastrointestinal function caused by poor diet, thus achieving a significant self-healing effect. They are characterized by definite curative effect, wide applicability to diseases, convenient use, and no toxic side effects.

[0056] Currently, the new generation of food and medicine homology + biological beverage of this invention has been evaluated by doctors and traditional Chinese medicine experts in some hospitals in Guangxi. Compared with the original probiotics, it is believed that there are few food-grade beverages with this effect in the same type of beverage, and it is about to be used as a hospital preparation for trial.

[0057] This invention regulates the gut microbiota by consuming a food-medicine homology + biological beverage, aiding digestion and promoting the efficient digestion of food by the liver and gallbladder. It also facilitates the absorption of protein, fat, amino acids, and vitamins from food by the small intestine, promoting nutritional balance and inhibiting various diseases of the five internal organs, thus ensuring good health. In terms of theory and practice, this invention primarily inherits and innovates upon Zhang Zhongjing's *Treatise on Febrile Diseases* and Li Donghuan's *Treatise on the Spleen and Stomach*. Firstly, because the spleen is located close to the left and back of the stomach, and below it is the left colic flexure, the stomach receives food, and the spleen transforms the essence of the food. Stomach qi descends, and spleen qi ascends, working together to complete the digestion and absorption of food. Secondly, it promotes blood circulation: the shared "blood bond" is the core deep connection between the two, realized through the portal venous system, replacing prescriptions and traditional Chinese medicine with a non-drug therapy based on food-medicine homology to restore human health.

[0058] This invention utilizes a non-drug therapy derived from food and medicine, incorporating over ten types of bacteria to replace prescriptions and traditional Chinese medicine for restoring health. This results in a stronger detoxification response, also known as a Herxheimer reaction, compared to existing technologies. Similarly, when addressing blockages in the middle and lower jiao (digestive systems), it can lead to increased frequency and volume of urination and defecation. Detailed Implementation

[0059] Example 1

[0060] (1) Use commercially available fructooligosaccharide products as component A.

[0061] (2) Weigh out 5g of cinnamon, 5g of red pine mushroom, 5g of kudzu root, 2g of dried tangerine peel, 3g of golden camellia flower, 5g of lemon, 3g of wild grape, 3g of moringa leaf, 3g of fig, 3g of eucommia bark, 3g of cistanche, and 3g of monk fruit according to dry weight. Crush them and put them in a basket. Place the basket in an extraction tank and add 5 times the weight of the medicinal ingredients to the extraction tank. Immerse the basket in the purified water and soak for 2 hours. Then boil for 3-4 hours and filter out the liquid for later use. Add 3 times the weight of water to the dregs, boil and filter, and combine the filtrates. Then combine the filtrates with the probiotic group and put them into a fermentation tank. Add the following probiotics at a temperature of 30℃~40℃: fermented lactic acid bacteria CECT5716, Lactobacillus acidophilus NCFM, fermented lactic acid bacteria CECT 5716, and Lactobacillus helveticus R A mixture of equal weights of the following: 0052, *Lactobacillus plantarum* JYLP-326, *Bifidobacterium animalis* BB-12, *Lactobacillus reuteri* DSM 17938, *Bifidobacterium longum* subsp. *longum* BB 536, *Bifidobacterium longum* subsp. *infantum* M-63, *Bifidobacterium longum* subsp. *infantum* R 0033, *Bifidobacterium breve* M-16V, *Bifidobacterium animalis* subsp. *bi-07*, *Lactobacillus rhamnosus* HN 001, *Lactobacillus rhamnosus* MP 108, *Lactobacillus rhamnosus* GG (LGG), and *Bifidobacterium bifidum* R 0071. In component B, the liquid probiotic agent accounts for 1 part by weight; the extract of food-medicine homology traditional Chinese medicine ingredients accounts for 5-10 parts by weight; the remainder is purified water or mineral water. (3) Package component A and component B separately to obtain the product.

[0062] Example 2

[0063] (1) Use commercially available fructooligosaccharide products as component A.

[0064] (2) Weigh out 7g of cinnamon, 6g of red pine mushroom, 6g of kudzu root, 5g of dried tangerine peel, 2g of golden camellia flower, 4g of lemon, 3g of wild grape, 4g of moringa leaf, 4g of fig, 4g of eucommia bark, 4g of cistanche, and 4g of monk fruit according to dry weight. Crush them and put them in a basket. Place the basket in an extraction tank and add 5 times the weight of the medicinal ingredients to the extraction tank. Immerse the basket in the purified water and soak for 2 hours. Then boil for 3-4 hours and filter out the liquid for later use. Add 3 times the weight of water to the dregs, boil and filter, and combine the filtrates. Then combine the filtrates with the probiotic group and put them into a fermentation tank. At a temperature of 30℃~40℃, add the probiotic mixture and ferment for 20 days to obtain component B. The probiotic agent is fermenting lactic acid bacteria CECT5716 and Lactobacillus rhamnosus HN. A mixture of equal weights of Lactobacillus rhamnosus MP 108, Lactobacillus rhamnosus GG (LGG), Bifidobacterium longum BB536, Bifidobacterium breve M-16, Lactobacillus acidophilus NCFM, Lactobacillus reuteri DSM17938, Bifidobacterium BB12, Bifidobacterium bifidum R 0071, Lactobacillus plantarum JYLP-326, Bifidobacterium animalis subsp. HM019, and Lactobacillus helveticus R0052, wherein component B contains 2 parts by weight of probiotic liquid, 5-10 parts by weight of extract of food and medicine homology traditional Chinese medicine ingredients, and the remainder is purified water or mineral water.

[0065] (3) Package component A and component B separately to obtain the product.

[0066] Example 3

[0067] (1) Use commercially available fructooligosaccharide products as component A.

[0068] (2) Weigh out 8g of cinnamon, 8g of red pine mushroom, 6g of kudzu root, 2g of golden camellia flower, 3g of dried tangerine peel, 6g of lemon, 3g of wild grape, 5g of moringa leaf, 5g of fig, 3g of eucommia bark, 3g of cistanche, and 4g of monk fruit by dry weight. Crush them and put them in a basket. Place the basket in an extraction tank and add 5 times the weight of the medicinal ingredients to the extraction tank. Submerge the basket in the purified water and soak for 2 hours. Then boil for 3-4 hours and filter out the liquid for later use. Add 3 times the weight of water to the dregs, boil, filter, and combine the filtrates. Then combine the filtrates with the probiotics and put them into a fermentation tank. At a temperature of 30℃~40℃, combine the filtrates with the probiotics. The mixture is placed in a fermentation tank and fermented for 20 days at a temperature of 30℃~40℃ to obtain component B. The probiotic agent is an equal weight mixture of fermenting lactic acid bacteria CECT5716, Lactobacillus rhamnosus MP108, Bifidobacterium longum BB536, Bifidobacterium breve M-16, Lactobacillus acidophilus NCFM, Lactobacillus reuteri DSM17938, Bifidobacterium BB12, Bifidobacterium animalis subsp. HM019, and Lactobacillus helveticus R0052. In component B, the liquid weight of the probiotic agent is 3; the weight of the extract of food and medicine homology traditional Chinese medicine ingredients is 5-10; and the remainder is purified water or mineral water.

[0069] (3) Package component A and component B separately to obtain the product.

[0070] Example 4

[0071] (1) Use commercially available fructooligosaccharide products as component A.

[0072] (2) Weigh out 7 g of cinnamon, 5 g of red cone fungus, 6 g of kudzu root, 5 g of dried tangerine peel, 3 g of golden camellia, 6 g of lemon, 3 g of wild grape, 5 g of moringa leaves, 5 g of fig, 5 g of eucommia bark, 5 g of cistanche, and 3 g of monk fruit according to dry weight. Crush them and put them in a basket. Place the basket in an extraction tank. Add 5 times the weight of the food and medicine ingredients to the extraction tank and immerse the basket in the purified water. Soak for 2 hours and then boil for 3-4 hours. Filter out the liquid for later use. Add 3 times the amount of water to the dregs, boil and filter. Combine the filtrate and then combine it with the probiotic group. Put it into a fermentation tank. At a temperature of 30℃~40℃, add the probiotic mixture and ferment for 20 days to obtain component B. The probiotic agent is a mixture of equal weights of fermented lactic acid bacteria CECT5716, Bifidobacterium longum BB536, Bifidobacterium breve M-16, Lactobacillus acidophilus NCFM, Lactobacillus reuteri DSM17938, Bifidobacterium BB12, Lactobacillus plantarum JYLP-326, Bifidobacterium animalis subsp. HM019, Lactobacillus helveticus R0052, Lactobacillus rhamnosus HN 001, Lactobacillus rhamnosus MP 108, and Lactobacillus rhamnosus GG (LGG). In component B, the liquid part of the probiotic agent is 1-3 parts by weight; the extract of food and medicine homology traditional Chinese medicine ingredients is 5-10 parts by weight; and the remainder is purified water or mineral water.

[0073] (3) Package component A and component B separately to obtain the product.

[0074] Application Examples: This invention relates to a traditional Chinese medicine probiotic preparation for regulating the spleen, intestines, and stomach. Over the past few years, it has been found to have significant benefits in regulating the stomach, intestines, spleen, liver, gallbladder, and kidneys. For example, it addresses indigestion, with typical symptoms including abdominal distension and loss of appetite; gastritis, primarily manifested as upper abdominal pain accompanied by nausea and vomiting; gastric ulcers, characterized by regular upper abdominal pain, often occurring after meals, accompanied by vomiting and diarrhea; enteritis, constipation, or diarrhea; acute and chronic pancreatitis; and liver and gallbladder pain and discomfort, digestive abnormalities, jaundice, dark urine (like strong tea), abnormal bowel movements, decreased appetite, fever, and systemic symptoms. The above symptoms have all significantly improved; the main reason is that the Chinese herbal extracts contain the following raw materials: cinnamon, red cone fungus, kudzu root, dried tangerine peel, golden camellia, lemon, wild grape, moringa leaves, fig, eucommia, cistanche, and monk fruit; the probiotics include: fermented lactic acid bacteria, lactobacillus plantarum, bifidobacterium animalis, subspecies of bifidobacterium animalis, lactobacillus rhamnosus, lactobacillus helveticus, bifidobacterium longum, bifidobacterium breve, lactobacillus acidophilus, and lactobacillus reuteri. The combination of the above Chinese herbs and probiotics greatly reduces harmful bacteria in the human gastrointestinal tract, promotes the overall health of organs such as the stomach, intestines, spleen, liver, gallbladder, and kidneys, effectively controls heart, lung, and vascular diseases, and even reduces the occurrence of diseases such as tumors. With improved digestion, there are fewer ailments throughout the body, and immunity is greatly enhanced. Drinking it a few times a month will make one feel refreshed and greatly improve the quality of life.

[0075] Example 1 Mr. Qin, male, 39 years old, from Nanning City, Guangxi Province, is an employee of an enterprise. In November 2024, he began to experience gastrointestinal discomfort, indigestion, dizziness, sallow complexion, and occasional chills. He took Western medicine on his own, but there was no improvement. After taking the traditional Chinese medicine probiotic agent of this invention, which has the function of regulating the human spleen, intestines and stomach, his gastrointestinal tract returned to normal, his appetite improved significantly, and his mental state improved.

[0076] Example 2 Ms. Liu, 29 years old, from Guigang, Guangxi, began experiencing weakness, pale complexion, spontaneous sweating, dizziness, sallow complexion, shortness of breath, fatigue, stomach pain due to spleen deficiency, and loose stools after giving birth in February 2023. She took Western medicine but did not see any improvement. After taking the probiotic preparation of traditional Chinese medicine that regulates the function of the spleen, intestines and stomach of the present invention, the patient's mental state improved, the spontaneous sweating stopped, her complexion became rosy, and the symptoms of stomach pain due to spleen deficiency and loose stools were significantly improved.

[0077] Example 3 Mr. Li, male, 54 years old, from Beihai, Guangxi, began experiencing fatigue, spontaneous sweating, dizziness, sallow complexion, kidney deficiency and lower back pain, impotence and premature ejaculation, excessive stomach acid and stomach pain, and diabetes in November 2022. He took Western medicine without improvement. After taking the probiotic preparation of traditional Chinese medicine that regulates the spleen, intestines and stomach functions of the present invention for 2 months, the patient's appetite improved significantly, his mental state improved, and his symptoms such as kidney deficiency and lower back pain, impotence and premature ejaculation, excessive stomach acid and stomach pain were significantly improved. His diabetes was also well controlled, and he had a rosy complexion.

[0078] Example 4 Mr. Li, 43 years old, began experiencing fatigue, constipation, loose stools, dizziness, sallow complexion, and diabetes in November 2024. He took Western medicine without improvement. After taking the probiotic preparation of traditional Chinese medicine that regulates the spleen, intestines, and stomach functions of this invention for two months, his appetite improved significantly, his constipation and loose stools improved, his mental state improved, and his symptoms such as excessive stomach acid and stomach pain improved significantly. His diabetes was also well controlled.

[0079] Example 5 Mr. Wu, 43 years old, began experiencing fatigue, constipation, loose stools, sallow complexion, and stomach pain in November 2023. He took Western medicine without improvement. After taking the traditional Chinese medicine probiotic preparation of this invention, which regulates the spleen, intestines, and stomach, for 3 months, his appetite improved significantly, his constipation, loose stools, and mental state improved, and his symptoms such as excessive stomach acid and stomach pain returned to the health condition he had before the illness.

[0080] Example 6 Mr. Wei, male, 65 years old, from Nanning, Guangxi, traveled to Xinjiang in June 2025. Due to the change in environment and eating too much melon, he suffered from diarrhea for 6 days, felt weak when walking, and lost 10 pounds. He took Baoji Pills but did not get better. After taking the traditional Chinese medicine probiotic agent of this invention, which has the function of regulating the human spleen, intestines and stomach, for only two days, twice a day, the diarrhea stopped.

[0081] Example 7, Mr. Deng, a 58-year-old male from Liuzhou, Guangxi, had been experiencing bad breath and intestinal problems before 2023. He would get diarrhea after eating cold food or fruits. He also had underlying conditions such as hypertension and kidney stones. He had visited hospitals in Liuzhou, but his condition did not improve significantly. In February 2023, he began drinking the probiotic supplement of this invention, starting with 20ml daily. He experienced diarrhea for the first few days, which the inventor explained was the body expelling toxins and cleaning up waste. Sure enough, after a few days, his condition improved significantly, and the diarrhea stopped. He then increased the dosage from 20ml daily to 50ml twice a day, morning and evening. After a month, his health returned to normal; he no longer experienced diarrhea easily, and his bad breath disappeared. Currently, his digestive system is completely normal, and his blood pressure has also decreased.

[0082] Example 8 Ms. Zhang, 32 years old, from Wuming District, Nanning, Guangxi, gave birth to twins in August 2025. Postpartum, she experienced loss of appetite, insufficient breast milk, and her babies cried frequently. The inventor specifically addressed her situation by doubling the dosage of cinnamon and *Pleurotus erythrorhizon* in a traditional Chinese medicine extract (added to Example 3). The dosage of Bifidobacterium was also doubled in the probiotic formulation. Ms. Zhang was given 50ml of the improved probiotic agent of this invention daily for 10 days. Her appetite increased significantly, and her breast milk became more abundant. We believe that increasing the dosage of cinnamon, *Pleurotus erythrorhizon*, and Bifidobacterium is very beneficial for women, promoting bowel regularity and increasing appetite. *Pleurotus erythrorhizon* and Bifidobacterium may also be related to lactation. These are essential nutrients for postpartum recovery. After drinking the probiotic, her twins, being well-fed, stopped crying and grew healthily.

[0083] Example 9 Ms. Xu, a 17-year-old female high school student in Beijing, moved from Guangxi to Beijing to study in August 2025. Initially, due to difficulties adapting to the environment and the unfamiliar school food, she frequently drank Coca-Cola. Later, she experienced stomach pain, organ prolapse, abdominal distension, loose stools, poor appetite, thirst, and daily unformed stools. An ultrasound examination revealed an enlarged spleen by a quarter, high blood sugar (fasting 8.5 mmol / L, postprandial 12.6 mmol / L), and she temporarily suspended her studies for one semester. During the Spring Festival of 2026, her family sent her a traditional Chinese medicine probiotic supplement that regulates the spleen and stomach functions. She drank 30ml daily, once a day. After three months, her appetite improved significantly, her stomach pain, constipation, and unformed stools improved, and her mental state returned to its pre-illness condition. Her fasting blood sugar was 4.8 mmol / L, her postprandial blood sugar was 7.6 mmol / L, and her spleen gradually returned to normal. She is now attending school normally.

Claims

1. A traditional Chinese medicine probiotic preparation that regulates the spleen, intestines, and stomach functions of the human body, characterized in that: Composed of component A and component B, component A contains fructooligosaccharides in a weight ratio of 20-49%, and component B consists of a probiotic agent and an extract of traditional Chinese medicinal herbs. The probiotic agent comprises an equal weight mixture of fermenting lactic acid bacteria, *Lactobacillus plantarum*, *Bifidobacterium animalis*, *Bifidobacterium animalis* subsp. *animal*, *Lactobacillus rhamnosus*, *Lactobacillus helveticus*, *Bifidobacterium longum*, *Bifidobacterium breve*, *Lactobacillus acidophilus*, and *Lactobacillus reuteri*. The extract of traditional Chinese medicinal herbs comprises cinnamon, *Pleurotus erythrorhizon*, kudzu root, dried tangerine peel, and *Camellia chrysantha* flowers. It is extracted from the following traditional Chinese medicine raw materials: lemon, wild grape, moringa leaves, fig, eucommia, cistanche, and monk fruit; the liquid weight of the probiotic agent is 1-3; the weight of the food and medicine homology traditional Chinese medicine extract is 5-10; the remainder is purified water or mineral water; the dry weight of each of the traditional Chinese medicine raw materials is as follows: cinnamon 6-8, red cone fungus 5-8, kudzu root 4-6, dried tangerine peel 3-5, golden camellia flower 2-3, lemon 3-6, wild grape 3-5, moringa leaves 3-5, fig 3-5, eucommia 3-5, cistanche 3-5, and monk fruit 3-5.

2. The traditional Chinese medicine probiotic agent for regulating the spleen, intestines, and stomach functions according to claim 1, characterized in that: The probiotic agent is a mixture of equal weights of Lactobacillus acidophilus NCFM, Lactobacillus fermentum CECT 5716, Lactobacillus helveticus R 0052, Lactobacillus plantarum JYLP-326, Bifidobacterium animalis BB-12, Lactobacillus reuteri DSM 17938, Bifidobacterium longum subsp. longum BB 536, Bifidobacterium longum subsp. infantum M-63, Bifidobacterium longum subsp. infantum R 0033, Bifidobacterium breve M-16V, Bifidobacterium subsp. HM019, Bifidobacterium animalis subsp. Bi-07, Lactobacillus rhamnosus HN 001, Lactobacillus rhamnosus MP 108, Lactobacillus rhamnosus GG (LGG), and Bifidobacterium bifidum R 0071.

3. The traditional Chinese medicine probiotic agent with the function of regulating the human spleen, intestines and stomach according to claim 1, characterized in that: The preparation method of component B is as follows: cinnamon, red pine mushroom, kudzu root, dried tangerine peel, golden camellia flower, lemon, wild grape, moringa leaf, fig, eucommia bark, cistanche, and monk fruit are weighed according to dry weight, crushed, and placed in a basket. The basket is then placed in an extraction tank, and five times the weight of the Chinese medicine in purified water is added to the extraction tank. The basket is submerged in the purified water and soaked for 2 hours, then boiled for 3-4 hours. The liquid is filtered out and set aside. The dregs are boiled again with three times the weight of water, filtered, and the filtrates are combined. Then, the filtrates are combined with probiotics and placed in a fermentation tank. The probiotic mixture is added at a temperature of 30℃~40℃ and fermented naturally for more than 20 days to obtain component B. In Component B, the liquid portion of the probiotic agent is 1-3 parts by weight; the extract of food and medicine homology traditional Chinese medicine ingredients is 5-10 parts by weight; and the remainder is purified water or mineral water.

4. The traditional Chinese medicine probiotic preparation for regulating the spleen, intestines, and stomach functions as described in claim 1, characterized in that: The method of administration is as follows: Open the caps of components A and B, pour the liquid from bottle B into bottle A, tighten the cap, shake well, and drink directly within 5 to 30 minutes.