A CAR-NK cell reinfusion treatment bolus device

Abstract

The application relates to the technical field of medical devices, in particular to a CAR-NK cell transfusion treatment push injection device, which comprises a base and a transfusion tube, the side wall of the base is fixedly connected with a shell, a traction ring is slidably matched in the side wall of the shell, a fixing assembly for fixing the transfusion tube is arranged in the traction ring; an arc-shaped sliding groove is formed in the side of the shell away from the base, a sliding assembly for driving the traction ring to slide along the sliding groove is arranged in the sliding groove; a center rod is rotationally matched in the shell, a push injection assembly for conveying liquid in the transfusion tube is arranged on the center rod; a protection assembly for protecting the transfusion tube is further arranged on the traction ring. Through the design of the traction ring, the device can quickly complete the installation and switching of the transfusion tube, and dynamically protect and monitor the state of the transfusion tube; after the installation of the transfusion tube is completed, the uniform conveying of CAR-NK cells is automatically realized, the operation complexity is effectively reduced, the installation efficiency and installation effect of the transfusion tube are improved, and the conveying quality of the CAR-NK cell conveying is guaranteed.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a CAR-NK cell reinfusion therapy injection device. Background Technology

[0002] CAR-NK cells, as a promising adoptive immunotherapy, have attracted widespread attention due to their inherent anti-tumor cytotoxicity and low risk of graft-versus-host disease. However, the safe and effective reinfusion of laboratory-prepared CAR-NK cells into patients is a crucial step in clinical translation. CAR-NK cells possess unique biological vulnerabilities, being extremely sensitive to physical shear forces, temperature changes, and mechanical stress during handling. Any improper handling can lead to decreased cell viability, impaired function, or even cell death, directly impacting treatment efficacy.

[0003] In current clinical practice, medical peristaltic pumps are widely used for CAR-NK cell reinfusion to ensure the gentleness and stability of the infusion process. For example, the LongerPump DG15-24 peristaltic pump produced by Baoding Longer Constant Flow Pump Co., Ltd. uses a push rod to alternately squeeze the infusion tubing, driving the fluid inside the tubing to flow in a specific direction. This avoids direct contact between the fluid and the pump body, reduces the physical shearing of the fluid, and also reduces the risk of contamination.

[0004] However, existing peristaltic pumps have significant shortcomings in the installation and operation of the infusion tubing. Medical staff need to insert the soft, thin infusion tubing into the pump's inlet and then push it forward until the end of the tubing emerges from the outlet. Afterward, manual adjustment and additional securing mechanisms are required to lock it in place. This process is not only cumbersome and time-consuming, but also prone to compression or deformation of the tubing due to uneven pushing force during the pushing and positioning process. This affects the flow stability of the cell suspension within the tubing, posing a potential risk of damage to the already fragile CAR-NK cells and severely impacting the delivery efficacy of CAR-NK cells. Therefore, this invention provides a CAR-NK cell reinfusion therapy injection device to solve the above problems. Summary of the Invention

[0005] To address the aforementioned issues, this invention provides a CAR-NK cell reinfusion therapy injection device. Through the design of a traction ring, the device can quickly complete the installation and switching of the infusion tubing, and dynamically protect and monitor the status of the infusion tubing. After the infusion tubing is installed, it automatically achieves uniform delivery of CAR-NK cells, effectively reducing operational complexity, improving the installation efficiency and effect of the infusion tubing, and ensuring the delivery quality of CAR-NK cells.

[0006] To achieve the above objectives, the technical solution of the present invention is as follows: A CAR-NK cell reinfusion therapy injection device includes a base and an infusion tube. A housing is fixedly connected to the side wall of the base, and the bottom of the housing has a first port and a second port for inserting the infusion tube. A traction ring is slidably fitted inside the side wall of the housing, and a fixing component for fixing the infusion tube is provided inside the traction ring. An arc-shaped sliding groove is opened on the side of the housing away from the base, and a sliding component for driving the traction ring to slide along the sliding groove is provided inside the sliding groove. A central rod is rotatably fitted inside the housing, and an injection component for conveying the liquid in the infusion tube is provided on the central rod. A protective component for protecting the infusion tube is also provided on the traction ring.

[0007] The technical principle of the above solution is as follows:

[0008] Medical staff insert one end of the infusion tube into the first port and extend the tube into the traction ring. The portion of the infusion tube within the traction ring is then secured using a fixing component. After securing, the central rod is rotated, causing the sliding component to move. This component drives the traction ring along a sliding groove, which in turn moves the infusion tube synchronously. During this process, the traction ring moves the infusion tube from the first port into the outer casing, wrapping it around the surface of the injection component. The tube is then moved to the second port, and the medical staff pulls it to the designated length, completing the securing and installation of the infusion tube. During the movement of the traction ring, a protective component is also fitted onto the portion of the infusion tube inside the outer casing. After installation, the central rod is rotated again, causing the injection component to compress the infusion tube and deliver the fluid within.

[0009] The above approach has the following beneficial effects:

[0010] 1. While existing injection devices can achieve gentle delivery of CAR-NK cells, the installation process of the infusion tubing is cumbersome and time-consuming. In contrast, this invention, through the design of a traction ring, can automatically fix the infusion tubing and pull it along a designated path, guiding the infusion tubing from the first port to the second port, thus achieving rapid installation of the infusion tubing, effectively reducing the operational difficulty of infusion tubing installation, and improving operational efficiency.

[0011] 2. In the prior art, during the installation of the infusion tube, uneven pushing force can cause the infusion tube to be squeezed or twisted and deformed, which in turn affects the flow stability and delivery effect of the cell suspension inside the tube. The present invention effectively ensures the stable and uniform movement of the traction ring through mechanical drive, so that the traction ring can drive the infusion tube to move with uniform traction force, effectively reducing the deformation of the infusion tube caused by uneven force, and providing a stable delivery space for the subsequent delivery of cell suspension.

[0012] 3. This invention can realize multiple functions such as infusion tube installation, infusion tube protection and cell suspension delivery by relying only on the rotation of the central rod and the transmission of the mechanical structure. It does not require multiple drive sources, which effectively improves the continuity of infusion tube installation and cell suspension delivery operations, improves the operational efficiency of the entire treatment process, and reduces the production cost of the device.

[0013] Furthermore, the sliding assembly includes a sliding rod that is slidably fitted in the sliding groove. The sliding rod is fixedly connected to the outer wall of the traction ring. A driving assembly for driving the sliding rod to slide along the sliding groove is provided on the central rod. An electrically controlled telescopic rod is fixedly connected to the end of the sliding rod away from the traction ring. The controller is used to control the operation of the electrically controlled telescopic rod.

[0014] Beneficial effects: This solution, through the limiting effect of the sliding groove and the sliding of the sliding rod, can drive the traction ring to slide stably along the specified trajectory, thus ensuring the stability of the traction operation.

[0015] Furthermore, the drive assembly includes a drive component embedded in the base, the output shaft of the drive component is coaxially and fixedly connected to the center rod, a controller is fixedly connected to the side wall of the base, the controller is used to control the operation of the drive component, the end of the center rod away from the drive component extends to the outside of the housing and is fixedly connected to a turntable, a lever is fixedly connected to the side wall of the turntable, and an electrically controlled telescopic rod abuts against the lever.

[0016] Beneficial effects: This solution uses the rotation of the central rod, turntable, and lever to move the electrically controlled telescopic rod, sliding rod, and traction ring, thus enabling the installation of the infusion tubing. Simultaneously, the design of the electrically controlled telescopic rod allows it to retract after installation via a controller, preventing interference with the fluid delivery process and ensuring coordinated installation and infusion operations.

[0017] Furthermore, the fixing component includes a support rod that slides radially against the side wall of the traction ring, with an arc-shaped support plate fixedly connected to one end of the support rod, the support plate being located inside the traction ring; the sliding rod is provided with an adjustment component for driving the support rod to slide radially along the side wall of the traction ring.

[0018] Beneficial effects: This solution, through the design of support rods and support plates, can effectively fix infusion tubes of different sizes; at the same time, it can also squeeze the infusion tubes to adjust the flow diameter of the infusion tubes, thereby adjusting the output of the infusion tubes.

[0019] Furthermore, the sliding rod is hollow inside, and the adjustment assembly includes an electric control cylinder fixedly connected to the inner wall of the sliding rod, and a support rod extending into the sliding rod from the end away from the support plate and fixedly connected to the output shaft of the electric control cylinder; the controller is used to control the operation of the electric control cylinder.

[0020] Beneficial effects: This solution, through the design of an electrically controlled cylinder, allows medical staff to quickly adjust the position of the support rod and support plate, thereby rapidly achieving the fixation of the infusion tube and the adjustment of the infusion volume.

[0021] Furthermore, the injection assembly includes a push rod that is circumferentially fixed to the side wall of the central rod. All push rods are located inside the housing, and each push rod is equipped with a buffer assembly to reduce the friction between the push rod and the infusion tubing.

[0022] Beneficial effects: When the central rod rotates, it drives the push rod to rotate, which in turn pushes the fluid in the infusion tube forward. This delivery method is gentle and uniform, which can effectively reduce the risk of cell damage and improve the effectiveness of treatment.

[0023] Furthermore, the buffer assembly includes a roller rotatably connected to the side of the push rod away from the center rod.

[0024] Beneficial effects: This solution, through the design of rollers, can effectively reduce the friction between the push rod and the infusion tube, reduce the risk of infusion tube breakage, increase the service life of the infusion tube, and reduce medical costs.

[0025] Furthermore, the protective component includes a protective tube detachably connected to the side of the traction ring near the first port, the length of which is not less than the length of the sliding groove; the protective tube is equipped with a detection component for detecting the status of the infusion tube.

[0026] Beneficial effects: When the traction ring slides along the sliding groove, it also drives the protective tube to move synchronously, so that the protective tube covers the second opening from the first opening, thereby protecting the infusion tube inside the traction ring. The squeezing action of the push rod and roller will be transmitted to the infusion tube through the protective tube, avoiding direct contact between the push rod and roller and the infusion tube, further reducing the risk of infusion tube breakage.

[0027] Furthermore, a display and an alarm are installed on the side wall of the base, and a controller is used to control the operation of the display and the alarm; the detection component includes several humidity sensors embedded in the inner walls of both ends of the protective tube, and the humidity sensors are used to collect the humidity inside the protective tube; the controller is used to input the humidity threshold, and when the humidity inside the protective tube is greater than the humidity threshold, the controller controls the alarm to operate; the controller is also used to display the humidity threshold and the humidity inside the protective tube through the display.

[0028] Beneficial effect: When the infusion tube is damaged, the liquid inside the infusion tube will flow to both ends of the protective tube under the action of gravity. At this time, the humidity at both ends of the protective tube will increase significantly, which can be used to effectively determine whether the infusion tube is broken.

[0029] Furthermore, the detection component also includes several pressure sensors embedded in the traction ring. The pressure sensors are used to collect the pressure between the protective tube and the traction ring. The controller is used to input the pressure threshold. When the pressure between the protective tube and the traction ring is greater than the pressure threshold, the controller controls the electric cylinder and drive components to operate. When the electric cylinder and drive components operate, and the pressure between the protective tube and the traction ring is still greater than the pressure threshold, the controller controls the alarm to operate. The controller is also used to display the pressure threshold and the pressure between the protective tube and the traction ring on a display.

[0030] Beneficial effects: When the infusion tube becomes blocked, it will expand to a certain extent, and the pressure between the infusion tube and the protective tube will increase significantly. This can effectively determine whether the infusion tube is blocked. In addition, the push rod and roller will not come into contact with the two ends of the protective tube during rotation, which can effectively prevent the pressure sensor and humidity sensor from being damaged by the rotation of the push rod and roller, and at the same time prevent the push rod and roller from interfering with the accuracy of the detection results. Attached Figure Description

[0031] Figure 1 This is an isometric view of the CAR-NK cell reinfusion therapy injection device of the present invention.

[0032] Figure 2 for Figure 1 Enlarged view of part A in the middle.

[0033] Figure 3 This is a front view of the outer casing of the CAR-NK cell reinfusion therapy injection device of the present invention.

[0034] Figure 4 This is a rear cross-sectional view of the outer casing of the CAR-NK cell reinfusion therapy injection device of the present invention.

[0035] Figure 5 This is an isometric sectional view of the outer casing of the CAR-NK cell reinfusion therapy injection device of the present invention.

[0036] Figure 6 This is a bottom view of the CAR-NK cell reinfusion therapy injection device of the present invention.

[0037] Figure 7 This is a cross-sectional view of the fixation component in the CAR-NK cell reinfusion therapy injection device of the present invention.

[0038] The reference numerals in the accompanying drawings of the instruction manual include: 1. Infusion tube; 2. Outer shell; 3. Base; 4. Controller; 5. Display; 6. Turntable; 7. Lever; 8. Electrically controlled telescopic rod; 9. Center rod; 10. Push rod; 11. Roller; 12. Support plate; 13. Support rod; 14. Electrically controlled cylinder; 15. Traction ring; 16. Protective tube; 17. Alarm; 18. Anti-slip sleeve; 19. Sliding rod; 201. First port; 202. Second port. Detailed Implementation

[0039] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0040] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0041] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0042] The following detailed description illustrates the specific implementation method:

[0043] Example 1:

[0044] like Figure 1 and Figure 2 As shown, a CAR-NK cell reinfusion therapy injection device includes a base 3 and an infusion tube 1. A controller 4 is bolted to the side wall of the base 3, and a housing 2 is bolted to the side wall of the base 3. The bottom of the housing 2 has a first port 201 and a second port 202 for inserting the infusion tube 1 (e.g., ...). Figure 5 and Figure 6 As shown); a traction ring 15 is slidably fitted inside the side wall of the outer casing 2 (as shown). Figure 4 and Figure 5 As shown), the traction ring 15 contains a fixing component for securing the infusion tube 1. The outer casing 2 has an arc-shaped sliding groove (as shown) on the side away from the base 3. Figure 1 and Figure 3 As shown), a sliding assembly for driving the traction ring 15 to slide along the sliding groove is provided inside the sliding groove. A central rod 9 (as shown) is rotatably fitted inside the outer casing 2. Figure 4 and Figure 5 As shown), the central rod 9 is equipped with a push assembly for conveying the liquid in the infusion tube 1.

[0045] like Figure 5 and Figure 7 As shown, the fixing assembly includes a support rod 13 that slides radially against the side wall of the traction ring 15. One end of the support rod 13 is fixedly bonded to an arc-shaped support plate 12, which is located inside the traction ring 15. The sliding assembly includes a sliding rod 19 that slides within a sliding groove. The sliding rod 19 is fixedly bonded to the outer side wall of the traction ring 15. An adjusting assembly for driving the support rod 13 to slide radially along the side wall of the traction ring 15 is provided inside the sliding rod 19. The sliding rod 19 is hollow. The adjusting assembly includes an electric cylinder 14 bolted to the inner side wall of the sliding rod 19. The end of the support rod 13 away from the support plate 12 extends into the sliding rod 19 and is bolted to the output shaft of the electric cylinder 14. The controller 4 is used to control the operation of the electric cylinder 14.

[0046] Specifically, such as Figure 5 As shown, in the initial state, the traction ring 15 is located at the first port 201. Medical personnel insert one end of the infusion tube 1 into the first port 201 and completely through the traction ring 15, causing one end of the infusion tube 1 to move above the traction ring 15. At this time, as... Figure 7 As shown, medical staff activate the electric control cylinder 14 via the controller 4, causing the output axis of the electric control cylinder 14 to extend upward, thereby pushing the support rod 13 and the support plate 12 to move upward. The inner wall of the traction ring 15 and the top wall of the support plate 12 are used to clamp and fix the infusion tube 1. Medical staff adjust the output of the electric control cylinder 14 via the controller 4 so that the device can fix infusion tubes 1 of different sizes. The larger the size of the infusion tube 1, the smaller the output of the electric control cylinder 14; conversely, the smaller the size of the infusion tube 1, the larger the output of the electric control cylinder 14.

[0047] Because the infusion tubing 1 has good deformation capacity, medical staff can adjust the flow cross-section of the infusion tubing 1 by adjusting the output of the electric control cylinder 14 after the infusion tubing 1 is fixed. The larger the output of the electric control cylinder 14, the greater the upward movement of the support rod 13 and the support plate 12, the greater the deformation of the infusion tubing 1, and the smaller its flow cross-sectional area. During the delivery of CAR-NK cell suspension, CAR-NK cells may settle, causing blockage of the infusion tubing 1. When the flow rate of the CAR-NK cell suspension is constant, appropriately reducing the flow cross-section can increase the flow velocity of the CAR-NK cell suspension at the traction ring 15, reducing the risk of cell sedimentation and blockage of the infusion tubing 1. Therefore, this embodiment, through the design of the support plate 12 and the support rod 13, can effectively improve the delivery therapy of CAR-NK cell suspension.

[0048] Combination Figure 1 and Figure 3 As shown, the central rod 9 is equipped with a drive assembly for driving the sliding rod 19 to slide along the sliding groove; the end of the sliding rod 19 away from the traction ring 15 is fixedly connected to an electrically controlled telescopic rod 8 located in the sliding groove, the sliding groove and the electrically controlled telescopic rod 8 are slidably engaged, and the controller 4 is used to control the operation of the electrically controlled telescopic rod 8. The drive assembly includes a drive component (in this embodiment, the drive component is a servo motor) embedded in the base 3, the output shaft of the servo motor is fixedly bolted to the central rod 9, the controller 4 is used to control the operation of the servo motor, the end of the central rod 9 away from the servo motor extends to the outside of the outer shell 2 and is fixedly bonded to a turntable 6, a lever 7 is fixedly bonded to the side wall of the turntable 6, and the electrically controlled telescopic rod 8 abuts against the lever 7. Figure 1 As shown, several anti-slip sleeves 18 are detachably engaged on the infusion tube 1 (in this embodiment, the anti-slip sleeves 18 are selected from the existing anti-slip buckles, which can prevent the infusion tube 1 from sliding during the delivery of CAR-NK cell suspension).

[0049] Specifically, such as Figure 3 As shown, in the initial state, the traction ring 15, sliding rod 19, and electrically controlled telescopic rod 8 are all located on the right side of the sliding groove, with the electrically controlled telescopic rod 8 in an extended state. The end of the lever 7 away from the turntable 6 is located below the electrically controlled telescopic rod 8. After the infusion tube 1 is fixed, medical staff can start the servo motor through the controller 4. The output shaft of the servo motor drives the central rod 9 to rotate counterclockwise. The central rod 9 will drive the turntable 6 and the lever 7 to rotate counterclockwise. The lever 7 will push the electrically controlled telescopic rod 8, sliding rod 19, and traction ring 15 to slide counterclockwise along the sliding groove, eventually moving to the left side of the sliding groove. During this process, due to the fixation of the support plate 12 and the traction ring 15, the traction ring 15 will drive one end of the infusion tube 1 to enter the outer shell 2 from the first port 201 and exit from the second port 202, thus quickly completing the traction of the infusion tube 1 inside the outer shell 2. Figure 1 As shown, at this time, medical staff only need to pull the infusion tube 1 from the second port 202 to extend it to the specified length, and then use the anti-slip buckle to lock it at the first port 201 and the second port 202 of the infusion tube 1, and then put the left end of the infusion tube 1 ( Figure 1 Connect the infusion tube 1 to the output source of the CAR-NK cell suspension (in this embodiment, the output source is a storage bag in the prior art), and connect the right end of the infusion tube 1 ( Figure 1 By connecting it to the patient, the installation of infusion tubing 1 can be completed quickly, effectively reducing the difficulty of installing infusion tubing 1 and improving installation efficiency.

[0050] like Figure 4 and Figure 5 As shown, the injection assembly includes a push rod 10 circumferentially fixed to the side wall of the central rod 9. All push rods 10 are located inside the housing 2, and each push rod 10 is provided with a buffer assembly to reduce the friction between the push rod 10 and the infusion tubing 1. The buffer assembly includes a roller 11 rotatably connected to the side of the push rod 10 away from the central rod 9.

[0051] Specifically, such as Figure 4 As shown, after the infusion tube 1 is installed, it will align with each roller 11 along the sliding groove, with the central rod 9 as the center. At this time, medical staff control the electrically controlled telescopic rod 8 to retract into the sliding groove via the controller 4, preventing the electrically controlled telescopic rod 8 from obstructing the lever 7 during the suspension delivery process. Then, the servo motor is started again, and the output shaft of the servo motor drives the central rod 9 to rotate clockwise. Figure 4 The central rod 9 will drive the push rod 10 and the roller 11 to rotate clockwise. When the roller 11 rotates, it will continuously squeeze the infusion tube 1, thereby realizing the delivery of liquid. During this process, medical staff can adjust the delivery time and delivery rate by adjusting the running time and output power of the servo motor.

[0052] like Figure 4 and Figure 5 As shown, the traction ring 15 is also provided with a protective component for protecting the infusion tube 1. The protective component includes a protective tube 16 (in this embodiment, the protective tube 16 is a silicone flexible tube) that is detachably engaged with the side of the traction ring 15 near the first port 201, and the length of the protective tube 16 is not less than the length of the sliding groove.

[0053] Specifically, such as Figure 4 and Figure 5 As shown, when medical staff install the infusion tube 1, they insert the infusion tube 1 through the protective tube 16 into the first port 201 and extend it to the traction ring 15. When the traction ring 15 moves the infusion tube 1 along the sliding groove, the traction ring 15 also moves the protective tube 16 synchronously into the outer shell 2. Since the length of the protective tube 16 is not less than the length of the sliding groove, under the traction of the traction ring 15, the protective tube 16 can cover the second port 202 from the first port 201, thereby protecting the infusion tube 1 inside the outer shell 2. The squeezing action of the push rod 10 and the roller 11 will be transmitted to the infusion tube 1 through the protective tube 16, avoiding direct contact between the push rod 10 and the roller 11 and the infusion tube 1, further reducing the risk of damage to the infusion tube 1.

[0054] This embodiment, through the design of the traction ring 15, can automatically fix the infusion tube 1 and pull it along a designated path, realizing the rapid installation of the infusion tube 1, effectively reducing the operational difficulty of installing the infusion tube 1 and improving operational efficiency. Through mechanical drive, the stable and uniform movement of the traction ring 15 is effectively ensured, thereby enabling the traction ring 15 to drive the infusion tube 1 with uniform traction force, effectively reducing the deformation of the infusion tube 1 caused by uneven force, and providing a stable delivery space for the subsequent delivery of cell suspension. Moreover, relying only on the rotation of the central rod 9 and the transmission of the mechanical structure, multiple functions such as infusion tube 1 installation, infusion tube 1 protection, and cell suspension delivery can be realized simultaneously without the need for multiple drive sources, effectively improving the continuity of the infusion tube 1 installation and cell suspension delivery operations, improving the operational efficiency of the entire treatment process, and reducing the production cost of the device.

[0055] Example 2:

[0056] Unlike the embodiments described above, as Figure 2 and Figure 4 As shown, the protective tube 16 contains a detection component for detecting the status of the infusion tube 1. A display 5 and an alarm 17 are mounted on the side wall of the base 3. A controller 4 controls the operation of the display 5 and the alarm 17. The detection component includes several humidity sensors embedded in the inner walls of both ends of the protective tube 16. These humidity sensors collect the humidity inside the protective tube 16. The controller 4 records a humidity threshold. When the humidity inside the protective tube 16 exceeds the humidity threshold, the controller 4 activates the alarm 17. The controller 4 also displays the humidity threshold and the humidity inside the protective tube 16 on the display 5.

[0057] Specifically, such as Figure 4 As shown, when the infusion tube 1 is damaged, the liquid inside the infusion tube 1 will flow to the inner walls of both ends of the protective tube 16 under the action of gravity. At this time, the humidity of the inner walls of both ends of the protective tube 16 will increase significantly. When the humidity inside the protective tube 16 exceeds the humidity threshold, the alarm 17 will immediately sound an alarm: "The infusion tube 1 may be damaged. Please check it in time." This reminds medical staff to replace the infusion tube 1 in time.

[0058] like Figure 4 As shown, the push rod 10 and roller 11 will not come into contact with the two ends of the protective tube 16 during rotation, which can effectively prevent the humidity sensor from being damaged by the squeezing of the push rod 10 and roller 11.

[0059] The detection assembly also includes several pressure sensors embedded in the traction ring 15. The pressure sensors are used to collect the pressure between the protective tube 16 and the traction ring 15. The controller 4 is used to input the pressure threshold. When the pressure between the protective tube 16 and the traction ring 15 is greater than the pressure threshold, the controller 4 controls the electric cylinder 14 and the drive unit to operate. When the electric cylinder 14 and the drive unit operate, and the pressure between the protective tube 16 and the traction ring 15 is still greater than the pressure threshold, the controller 4 controls the alarm 17 to operate and controls the electric cylinder 14 and the drive unit to operate. The controller 4 is also used to display the pressure threshold and the pressure between the protective tube 16 and the traction ring 15 through the display 5.

[0060] Specifically, when infusion tube 1 becomes blocked, both infusion tube 1 and protective tube 16 will expand to a certain extent. At this time, the pressure between traction ring 15 and protective tube 16 will increase significantly. When the pressure between protective tube 16 and traction ring 15 exceeds the pressure threshold, the controller will alternately pause and start the drive component, thereby generating a pulse effect. The instantaneous rapid flow of liquid will impact the blockage, thus clearing infusion tube 1. At the same time, the controller will also control the output shaft of electric cylinder 14 to repeatedly extend and retract, further generating a pulse effect to improve the clearing effect. If the pressure still does not decrease after the above operations, the controller will activate alarm 17, which will immediately sound an alarm: "Infusion tube 1 may be blocked, please check it in time." This reminds medical staff to clear or replace infusion tube 1 in a timely manner.

[0061] like Figure 4 As shown, the push rod 10 and roller 11 will not contact the two ends of the protective tube 16 during rotation, which can effectively prevent the pressure sensor from being damaged by the squeezing of the push rod 10 and roller 11. At the same time, it can prevent the pressure generated when the push rod 10 and roller 11 squeeze the protective tube 16 from being misjudged as the pressure generated by the expansion of the infusion tube 1, thus ensuring the accuracy of the detection results.

[0062] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A CAR-NK cell reinfusion therapy injection device, comprising a base (3) and an infusion tube (1), wherein a shell (2) is fixedly connected to the side wall of the base (3), and the bottom of the shell (2) has a first port (201) and a second port (202) for inserting the infusion tube (1); characterized in that, A traction ring (15) is slidably fitted inside the side wall of the outer shell (2), and a fixing component for fixing the infusion tube (1) is provided inside the traction ring (15); The outer shell (2) has an arc-shaped sliding groove on the side away from the base (3), and a sliding component for driving the traction ring (15) to slide along the sliding groove is provided in the sliding groove; A central rod (9) is rotatably fitted inside the outer casing (2), and a push assembly for conveying the liquid in the infusion tube (1) is provided on the central rod (9); The traction ring (15) is also equipped with a protective component for protecting the infusion tube (1).

2. The CAR-NK cell reinfusion therapy injection device according to claim 1, characterized in that, The sliding assembly includes a sliding rod (19) that slides in the sliding groove. The sliding rod (19) is fixedly connected to the outer wall of the traction ring (15). The center rod (9) is provided with a driving assembly for driving the sliding rod (19) to slide along the sliding groove. An electrically controlled telescopic rod (8) is fixedly connected to one end of the sliding rod (19) away from the traction ring (15). The controller (4) is used to control the operation of the electrically controlled telescopic rod (8).

3. The CAR-NK cell reinfusion therapy injection device according to claim 2, characterized in that, The drive assembly includes a drive component embedded in the base (3), the output shaft of the drive component is coaxially fixedly connected to the center rod (9), a controller (4) is fixedly connected to the side wall of the base (3), the controller (4) is used to control the operation of the drive component, the end of the center rod (9) away from the drive component extends to the outside of the housing (2) and is fixedly connected to a turntable (6), a lever (7) is fixedly connected to the side wall of the turntable (6), and an electrically controlled telescopic rod (8) abuts against the lever (7).

4. The CAR-NK cell reinfusion therapy injection device according to claim 1, characterized in that, The fixing assembly includes a support rod (13) that slides radially with the side wall of the traction ring (15). One end of the support rod (13) is fixedly connected to an arc-shaped support plate (12), which is located inside the traction ring (15). The sliding rod (19) is provided with an adjustment assembly for driving the support rod (13) to slide radially along the side wall of the traction ring (15).

5. The CAR-NK cell reinfusion therapy injection device according to claim 4, characterized in that, The sliding rod (19) is hollow inside. The adjustment assembly includes an electric control cylinder (14) fixedly connected to the inner wall of the sliding rod (19). The support rod (13) extends into the sliding rod (19) from the end away from the support plate (12) and is fixedly connected to the output shaft of the electric control cylinder (14). The controller (4) is used to control the operation of the electric control cylinder (14).

6. The CAR-NK cell reinfusion therapy injection device according to claim 1, characterized in that, The injection assembly includes a push rod (10) that is circumferentially fixed to the side wall of the central rod (9). The push rods (10) are all located inside the housing (2). Each push rod (10) is provided with a buffer assembly to reduce the friction between the push rod (10) and the infusion tube (1).

7. The CAR-NK cell reinfusion therapy injection device according to claim 6, characterized in that, The buffer assembly includes a roller (11) rotatably connected to the push rod (10) on the side away from the center rod (9).

8. The CAR-NK cell reinfusion therapy injection device according to claim 1, characterized in that, The protective assembly includes a protective tube (16) detachably connected to the traction ring (15) on the side near the first port (201), the length of the protective tube (16) being not less than the length of the sliding groove; the protective tube (16) is provided with a detection component for detecting the status of the infusion tube (1).

9. The CAR-NK cell reinfusion therapy injection device according to claim 8, characterized in that, A display (5) and an alarm (17) are installed on the side wall of the base (3). The controller (4) is used to control the operation of the display (5) and the alarm (17). The detection component includes several humidity sensors embedded in the inner walls of both ends of the protective tube (16). The humidity sensors are used to collect the humidity inside the protective tube (16). The controller (4) is used to input the humidity threshold. When the humidity inside the protective tube (16) is greater than the humidity threshold, the controller (4) controls the alarm (17) to run. The controller (4) is also used to display the humidity threshold and the humidity inside the protective tube (16) through the display (5).

10. The CAR-NK cell reinfusion therapy injection device according to claim 8, characterized in that, The detection component also includes several pressure sensors embedded in the traction ring (15), which are used to collect the pressure between the protective tube (16) and the traction ring (15); the controller (4) is used to input the pressure threshold. When the pressure between the protective tube (16) and the traction ring (15) is greater than the pressure threshold, the controller (4) controls the electric cylinder (14) and the drive unit to run; when the electric cylinder (14) and the drive unit run, if the pressure between the protective tube (16) and the traction ring (15) is still greater than the pressure threshold, the controller (4) controls the alarm (17) to run; the controller (4) is also used to display the pressure threshold and the pressure between the protective tube (16) and the traction ring (15) through the display (5).

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