A composition with soothing and repairing efficacy and its use

Abstract

The present application belongs to the technical field of cosmetics, and particularly relates to a composition with soothing and repairing effects and application thereof. The composition with soothing and repairing effects contains a Bauhinia championii bark extract, PDRN, SiRNA and mussel mucin, wherein the mussel mucin contains Mefp-1 type and Mefp-5 type in a specific weight ratio; the four components have a significant synergistic effect, and the four components can significantly improve the inhibitory effect of the composition on inflammatory factors; the composition obtained by scientific compounding of the four components has excellent soothing and repairing effects, is safe and efficient, and can be widely applied in the field of cosmetics.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a composition with soothing and repairing effects and its application. Background Technology

[0002] Sensitive skin is a common sub-healthy skin problem, caused by a combination of imbalances in the skin barrier, neurovascular system, and immune system. External factors such as ultraviolet radiation, environmental pollution, irritating skincare products, and improper skincare methods, as well as internal factors such as stress and endocrine disorders, can all damage the stratum corneum, causing epidermal lipid loss and disrupting the skin barrier function. Once the skin barrier is damaged, transepidermal water loss increases, the skin's tolerance threshold for irritation decreases, and it is more prone to triggering immune inflammatory responses, leading to discomfort such as burning, stinging, itching, and tightness, often accompanied by signs such as erythema, telangiectasia, and scaling.

[0003] Existing soothing and repairing skincare products have significant technological shortcomings, making it difficult to balance repair efficacy with safety. Conventional products often achieve temporary soothing by removing irritating ingredients such as fragrances, pigments, and alcohol, or by adding antihistamines, but they cannot fundamentally repair the damaged skin barrier. Long-term use can easily lead to skin dependence, and their anti-allergic effects are limited. While existing patent CN202110588884.7 discloses a soothing and repairing face cream containing purslane extract and peach resin extract, which can improve skin redness and dryness and is suitable for sensitive skin care, this technology's formulation system has limitations. Its overall anti-allergic, soothing, and barrier-repairing performance is insufficient, failing to meet the diverse repair needs of sensitive skin.

[0004] With the increasing number of people with sensitive skin, the market demand for safe and effective skin-soothing and repairing products is becoming increasingly urgent. Therefore, there is a pressing need in this field to develop a skincare composition that is novel in formulation, safe and gentle, and possesses both highly effective soothing and barrier-repairing capabilities. Summary of the Invention

[0005] In view of the above-mentioned defects or improvement needs of the prior art, the present invention provides a composition with soothing and repairing effects and its application, which solves the problems of poor efficacy and safety of existing skin care products.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: In a first aspect, the present invention provides a composition having soothing and repairing effects, comprising the following components in parts by weight: Bark extract of *Bretschneidera sinensis*: 0.7-1.3 parts; PDRN: 0.8-1.1 parts; siRNA: 1-1.3 parts; Mussel adhesive protein: 1.5-2 parts; The PDRN has an average molecular weight of 150-850 kDa; the siRNA has an average molecular weight of 13-14 kDa and is prepared by solid-phase synthesis; the mussel adhesive protein includes Mefp-1 and Mefp-5 types in a weight ratio of 7:2.5-4.

[0007] Preferably, the composition having soothing and repairing effects comprises the following components in parts by weight: Bark extract of the variegated bellflower tree: 1 part; PDRN: 0.9 copies; siRNA: 1.1 copies; Mussel adhesive protein: 1.7 parts; The PDRN has an average molecular weight of 200 kDa; the siRNA has an average molecular weight of 13.5 kDa; and the mussel adhesive protein comprises Mefp-1 and Mefp-5 in a weight ratio of 7:3.

[0008] Secondly, the present invention provides the use of the composition with soothing and repairing effects described in the first aspect in the preparation of cosmetics with soothing and repairing effects.

[0009] Preferably, the dosage form of the cosmetic with soothing and repairing effects includes any one of face cream, lotion, and serum.

[0010] Thirdly, the present invention provides a serum with soothing and repairing effects, the serum comprising 0.1-5 wt% of the composition with soothing and repairing effects described in the first aspect.

[0011] Preferably, the essence further comprises a moisturizer, a preservative, a thickener, a pH adjuster, and deionized water.

[0012] More preferably, the moisturizer is at least one of sodium hyaluronate, glycerin, and squalane.

[0013] More preferably, the preservative is at least one of p-hydroxyacetophenone, ethylhexylglycerin, and octyl glycol.

[0014] More preferably, the thickener is at least one of xanthan gum, hydroxyethyl cellulose, ammonium acryloyl dimethyl taurate / VP copolymer, and sodium polyacryloyl dimethyl taurate.

[0015] More preferably, the pH adjuster is tromethamine.

[0016] The beneficial effects of this invention are: The soothing and repairing composition of this invention contains *Bretschneidera sinensis* bark extract, PDRN, siRNA, and mussel adhesive protein, wherein the mussel adhesive protein contains Mefp-1 and Mefp-5 types in a specific weight ratio. The four components exhibit a significant synergistic effect, and their combined use significantly enhances the composition's inhibitory effect on inflammatory factors. *Bretschneidera sinensis* bark extract is rich in polyphenols and saponins, which can scavenge free radicals and possess strong antioxidant and anti-inflammatory effects. It can soothe skin problems such as erythema, itching, rashes, or pain caused by dust, microorganisms, and irritants, maintaining the skin's healthy condition for a long time. PDRN (polydeoxyribose)... Nucleotides are natural molecules derived from living organisms, possessing biological activities such as promoting cell regeneration and tissue repair, anti-inflammation, anti-oxidation, and repairing DNA damage. siRNA (small interfering RNA) can specifically degrade target mRNA, achieving highly efficient inhibition of protein expression. It has advantages such as target specificity, long-lasting effect, and designability, exhibiting excellent repair efficacy. Mussel adhesive protein is composed of 70-90 repeating polypeptide fragments, containing 20% ​​lysine and 10% dopa groups, exhibiting strong anti-inflammatory and antioxidant activity. The combination of these four components, scientifically formulated, has excellent soothing and repairing effects, and is safe and highly effective, making it widely applicable in the cosmetics field. Detailed Implementation

[0017] To further illustrate the technical means and effects of the present invention in achieving the intended purpose, the following detailed description of the specific embodiments, structure, features and effects of the present invention, in conjunction with the composition, is provided below.

[0018] For the following compositions, unless otherwise specified, experimental methods are generally performed under standard conditions or as recommended by the manufacturer. Unless otherwise specified, all materials and reagents used are commercially available.

[0019] Some of the raw materials and their sources are as follows: The bark of the variegated bellflower tree was purchased from Shanghai Qianfei Chemical Co., Ltd. PDRN was purchased from Ruijiming (Shandong) Biotechnology Co., Ltd.; SiRNA was purchased from Shanghai Shuyinxin Technology Co., Ltd. Mefp-1 was purchased from Shenzhen Baiyin Biotechnology Co., Ltd. Mefp-5 was purchased from Shenzhen Baiyin Biotechnology Co., Ltd. The preparation method of the variegated bellflower bark extract of this invention refers to the preparation method of variegated bellflower bark extract 1 disclosed in the patent "An antioxidant composition containing variegated bellflower bark extract and its application" (application number: CN202510334360.3), and the specific steps are as follows: S1. Air-dry the bark of the variegated bellflower tree until the moisture content is ≤5%, and grind it into coarse powder; S2. Mix coarse powder of variegated bellflower bark with rapeseed oil and polyglycerol-3 diisostearate, heat to 55°C, and stir at 300 rpm for 20 min to obtain a mixture; S3. Under N2 atmosphere, the mixture in S2 was subjected to ultrasonic-assisted extraction to obtain the extract. Extraction temperature: 55℃, ultrasonic frequency: 30 kHz, extraction time: 45 min. S4. Filter the extract to remove insoluble matter, centrifuge, and collect the supernatant to obtain the bark extract of the variegated bellflower tree; In step S2, the mass ratio of coarse bark powder of *Bretschneidera sinensis*, rapeseed oil, and polyglycerol-3 diisostearate is 1:3:0.2.

[0020] The composition (parts by weight) of the compositions with soothing and repairing effects in Examples 1-5 of this invention is shown in Table 1 below. Each component was weighed according to the formula amount, mixed and homogenized to obtain each composition.

[0021] Table 1. Components and their weight parts of the compositions in Examples 1-5 1 1 0.9 850 1.1 14 1.7 7：2.5 2 1 0.9 150 1.1 13 1.7 7：4 3 1 0.9 200 1.1 13.5 1.7 7：3 4 0.7 0.8 200 1 13.5 1.5 7：3 5 1.3 1.1 200 1.3 13.5 2 7：3 Comparative Example 1 Compared with Example 3, the difference is that Comparative Example 1 did not add the bark extract of Bellflower Tree, and the missing amount was made up with PDRN, siRNA and mussel adhesive protein in a weight ratio of 0.9:1.1:1.7. The average molecular weight of PDRN was 200 kDa and the average molecular weight of siRNA was 13.5 kDa. Other conditions and preparation methods were the same as in Example 3.

[0022] Comparative Example 2 Compared with Example 3, the difference is that PDRN was not added in Comparative Example 2. The missing amount was made up with the bark extract of *Bretschneidera sinensis*, siRNA and mussel adhesive protein in a weight ratio of 1:1.1:1.7. The average molecular weight of siRNA was 13.5 kDa. All other conditions and preparation methods were the same as in Example 3.

[0023] Comparative Example 3 Compared with Example 3, the difference is that siRNA was not added in Comparative Example 3. The missing amount was made up with the bark extract of *Bretschneidera sinensis*, PDRN and mussel adhesive protein in a weight ratio of 1:0.9:1.7. The average molecular weight of PDRN was 200 kDa. Other conditions and preparation methods were the same as in Example 3.

[0024] Comparative Example 4 Compared with Example 3, the difference is that mussel adhesive protein was not added in Comparative Example 4. The missing amount was made up by extract of *Bretschneidera sinensis* bark, PDRN and siRNA in a weight ratio of 1:0.9:1.1. The average molecular weight of PDRN was 200 kDa and the average molecular weight of siRNA was 13.5 kDa. Other conditions and preparation methods were the same as in Example 3.

[0025] Comparative Example 5 Compared with Example 3, the difference is that the mussel adhesive protein in Comparative Example 5 does not contain Mefp-1 type, and the missing amount is made up with Mefp-5 type. The average molecular weight of PDRN is 200 kDa, and the average molecular weight of siRNA is 13.5 kDa. Other conditions and preparation methods are the same as in Example 3.

[0026] Comparative Example 6 Compared with Example 3, the difference is that the mussel adhesive protein in Comparative Example 6 does not contain Mefp-5 type, and the missing amount is made up with Mefp-1 type. The average molecular weight of PDRN is 200 kDa, and the average molecular weight of siRNA is 13.5 kDa. Other conditions and preparation methods are the same as in Example 3.

[0027] Comparative Example 7 Compared with Example 3, the difference is that the bark extract of *Cyclocarya variegata* in Comparative Example 7 was replaced with an equal amount of *Rosa desertica* leaf cell extract, the average molecular weight of PDRN was 200 kDa, the average molecular weight of siRNA was 13.5 kDa, and other conditions and preparation methods were the same as in Example 3.

[0028] Comparative Example 8 Compared with Example 3, the difference is that the weight ratio of the bark extract of *Bretschneidera sinensis*, PDRN, siRNA and mussel adhesive protein in Comparative Example 8 is 1.8:1.6:1.8:1, the average molecular weight of PDRN is 200 kDa, the average molecular weight of siRNA is 13.5 kDa, and other conditions and preparation methods are the same as in Example 3.

[0029] Comparative Example 9 Compared with Example 3, the difference is that in Comparative Example 9, the weight ratio of Mefp-1 and Mefp-5 mussel adhesive proteins is 7:5, the average molecular weight of PDRN is 200 kDa, and the average molecular weight of siRNA is 13.5 kDa. All other conditions and preparation methods are the same as in Example 3.

[0030] The total weight of each composition in Examples 1-5 is the same as that in Comparative Examples 1-9.

[0031] Example 1: Composition Test Test samples: Compositions prepared in Examples 1-5 and Comparative Examples 1-9; Bacterial lipopolysaccharide (LPS) binds to the surface antigen recognition receptor of mouse monocytic leukemia cells RAW264.7, inducing macrophages to release the inflammatory mediator nitric oxide (NO). Excessive NO can promote the release of inflammatory factors such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) from macrophages, which in turn can promote the secretion of more NO, forming a vicious cycle and aggravating the inflammatory response. In this test case, the inhibition rate of inflammatory factors in the sample group after administration was measured to evaluate the inhibitory effect of the sample on the release of inflammatory factors, thereby evaluating whether the sample has soothing and anti-inflammatory effects.

[0032] IL-6 and TNF-α assay: RAW264.7 cells were collected, centrifuged, counted, and prepared with 2×10⁻⁶ cells. 5 0.5 mL of cell suspension was seeded into each well of a 24-well plate and cultured until cells adhered. The culture medium was removed from each well of the 24-well plate, and 200 μL of complete culture medium was added to each well of each group. The plates were then placed in an incubator and cultured for another 24 h. The culture medium was then removed from each well of the 24-well plate. For the model group, 200 μL of complete culture medium containing 1 μg / mL LPS was added, and for the sample group, 200 μL of complete culture medium containing 1 μg / mL LPS and 0.5 wt% sample was added. The plates were then placed in an incubator and cultured for another 24 h. The supernatant was transferred to a centrifuge tube and centrifuged at 1000g for 20 min. The supernatant was then used to detect changes in inflammatory factors according to the ELISA kit instructions. The inhibition rate of IL-6 / TNF-α was calculated using the following formula. The test results are shown in Table 2 below. ; In the formula: A 模型组 The average IL-6 / TNF-α ratio in the model group; A 样品组 This represents the average IL-6 / TNF-α content for each sample group. Table 2 Composition Data Example 1 41.36 60.83 Example 2 39.58 62.15 Example 3 42.60 63.91 Example 4 40.74 59.12 Example 5 39.19 57.46 Comparative Example 1 27.42 37.28 Comparative Example 2 29.63 39.17 Comparative Example 3 23.11 35.29 Comparative Example 4 26.05 36.16 Comparative Example 5 31.57 46.03 Comparative Example 6 30.64 44.20 Comparative Example 7 34.26 49.38 Comparative Example 8 35.82 52.07 Comparative Example 9 37.59 54.14 As shown in Table 2, the composition of this invention has significant anti-inflammatory and soothing effects. Combined with the results of Example 3 and Comparative Examples 1-4 and 7, it is evident that the extract of *Bretschneidera sinensis* bark, PDRN, siRNA, and mussel adhesive protein in this invention exhibit a significant synergistic effect; the combined use of these four components significantly enhances the inhibitory effect of the composition on inflammatory factors. Furthermore, combined with the results of Example 3 and Comparative Examples 5-6, it is evident that the combined use of Mefp-1 and Mefp-5 types of mussel adhesive protein in this invention significantly enhances the composition's effectiveness against IL-6 and TNF. The inhibitory effect of -α indicates a significant synergistic effect between Mefp-1 and Mefp-5 types. Combined with the results of Examples 3-5 and Comparative Example 8, it can be seen that the weight proportions of the *Cyclocarya variegata* bark extract, PDRN, siRNA, and mussel adhesive protein selected in this invention achieve the best efficacy within the scope defined by this invention. Combined with the results of Examples 1-3 and Comparative Example 9, it can be seen that the weight proportions of Mefp-1 and Mefp-5 types of mussel adhesive protein selected in this invention achieve the best efficacy within the scope defined by this invention.

[0033] Application example: A soothing and repairing serum The soothing and repairing compositions prepared in Examples 1-5 and Comparative Examples 1-9 were added to the serums to obtain the serums of Application Examples 1-5 and Comparative Application Examples 1-9, respectively.

[0034] The soothing and repairing essence comprises the following components by weight percentage: 2% of the aforementioned composition, 6% glycerin, 0.5% p-hydroxyacetophenone, 0.4% ammonium acryloyldimethyl taurate / VP copolymer, a suitable amount of tromethamine, and the balance being deionized water. The term "suitable amount" for tromethamine indicates that the pH needs to be adjusted to a specified pH, which is the pH specified in the essence preparation steps.

[0035] The preparation methods for the serums in Application Examples 1-5 and Comparative Application Examples 1-9 are as follows: Step 1: Mix the composition, p-hydroxyacetophenone, glycerol and 1 / 2 deionized water at 25°C until homogeneous to obtain mixture A; Step 2: Mix the ammonium acryloyldimethyl taurate / VP copolymer with 1 / 4 deionized water at 40°C to obtain mixture B; Step 3: After mixture B cools to 25°C, mix mixture B with mixture A and the remaining deionized water evenly and adjust the pH to 6 using tromethamine to obtain the essence.

[0036] The preparation method of the serum for the blank control group is as follows: Step 1: Mix p-hydroxyacetophenone, glycerol and 1 / 2 deionized water at 25°C until homogeneous to obtain mixture A; Step 2: Mix the ammonium acryloyldimethyl taurate / VP copolymer with 1 / 4 deionized water at 40°C to obtain mixture B; Step 3: After mixture B cools to 25°C, mix mixture B with mixture A and the remaining deionized water evenly and adjust the pH to 6 using tromethamine to obtain the essence.

[0037] Example 2: Safety Test Test substances: the essences prepared in Application Examples 1-5, Comparative Application Examples 1-9, and the blank control group.

[0038] Subject selection: Healthy subjects aged 31-47 years were selected who voluntarily participated and signed an informed consent form, and were able to complete the test as required during the testing period. Subjects were randomly assigned to groups of 5 subjects, with each group corresponding to one test substance.

[0039] Experimental method: Select qualified patch equipment, take 1g of the test substance and place it in the patch applicator and spread it evenly. Then, use topical hypoallergenic adhesive tape to apply the patch applicator to the flexor side of the subject's forearm. Remove the test substance after 24 hours. Observe and record the skin reaction at 0.5, 24 and 48 hours after removal.

[0040] Results evaluation: Adverse skin reactions were graded according to the classification of adverse skin reactions in human trials as specified in the "Cosmetic Safety Technical Specifications" (2015 edition). The grading criteria are shown in Table 3.

[0041] Table 3 Skin Reaction Scoring Criteria 0 negative reaction 1 Suspicious reaction, only slight erythema 2 Weak positive reaction (erythema reaction): erythema, infiltration, edema, and papules may be present. 3 Strong positive reaction (herpes reaction): erythema, infiltration, edema, papules; the reaction may extend beyond the test area. 4 Extremely strong positive reaction (confluent herpes simplex reaction): obvious erythema, severe infiltration, edema, confluent herpes simplex; reaction extends beyond the test area. Test results: All subjects showed negative skin reactions, indicating that the serum prepared using the composition of this invention does not cause allergic reactions, is non-irritating, and has high safety.

[0042] Example 3 of efficacy test: Human efficacy trial Recruit 75 healthy subjects (zygomatic bone water < 60 C.U., TEWL ≥ 20 g / hm) 2Participants were aged 25-40 years, with no obvious skin lesions or severe allergic reactions, and had not received any skin treatments or cosmetic procedures (such as lasers, injections, etc.) or used any medications that affected their skin condition within the past 6 months. They were randomly divided into 15 groups of 5 people each. On the day of their visit, participants washed their faces with water without applying any products and sat quietly for 20 minutes in an air-conditioned room with a temperature of 21±1℃ and humidity of 50±10%. Transdermal water loss (TEWL) was measured on the cheekbone using a Tewameter™ Hex probe, and the erythema index (a* value) was measured on the cheek using a Colorimeter CL440 skin color test probe. After washing their faces and waiting 10 minutes, TEWL and a* values ​​were measured as pre-use data. Participants used the serum twice daily, morning and evening, 1g each time. A follow-up visit was conducted after 28 days, and TEWL and a* values ​​were measured again. ; Where: TEWL value 第0天 The TEWL values ​​for each group before use (day 0); TEWL values 第28天 The TEWL values ​​for each group after use (day 28); ; In the formula: a* value 第0天 The a* value for each group before use (day 0); a* value 第28天 The a* value for each group after use (day 28); The results were taken as averages, as shown in Table 4. It can be seen that the serums prepared using Examples 1-5 can significantly improve the facial soothing and repairing effect, indicating that the bark extract of Bellflower Tree, PDRN, siRNA and mussel adhesive protein are combined in a specific ratio to achieve synergistic effects and achieve excellent soothing and repairing effects.

[0043] Specifically, combining the results of Application Example 3 with those of Comparative Application Examples 1-4 and 7, it can be seen that the *Bretschneidera sinensis* bark extract, PDRN, siRNA, and mussel adhesive protein in this invention exhibit a significant synergistic effect, and their combined use can significantly enhance the soothing and repairing effect of the essence. Combining the results of Application Example 3 with those of Comparative Application Examples 5-6, it can be seen that the combined use of Mefp-1 and Mefp-5 types of mussel adhesive protein in this invention can significantly enhance the soothing and repairing effect of the essence, indicating a significant synergistic effect between Mefp-1 and Mefp-5 types. Combining the results of Application Examples 3-5 with those of Comparative Application Example 8, it can be seen that the weight proportions of *Bretschneidera sinensis* bark extract, PDRN, siRNA, and mussel adhesive protein selected in this invention achieve the best efficacy within the scope defined by this invention. Combining the results of Application Examples 1-3 with those of Comparative Application Example 9, it can be seen that the weight proportions of Mefp-1 and Mefp-5 types of mussel adhesive protein selected in this invention achieve the best efficacy within the scope defined by this invention.

[0044] Table 4. Human Trial Evaluation Data Blank application example 2.69 1.71 Application Example 1 30.72 19.50 Application Example 2 31.94 18.47 Application Example 3 32.58 20.63 Application Example 4 30.10 18.15 Application Example 5 29.43 17.26 Comparative Application Example 1 18.31 11.59 Comparative Application Example 2 16.25 9.78 Comparative Application Example 3 19.46 12.65 Comparative Application Example 4 15.27 9.34 Comparative Application Example 5 23.80 13.92 Comparative Application Example 6 22.05 13.07 Comparative Application Example 7 25.14 14.53 Comparative Application Example 8 26.37 15.06 Comparative Application Example 9 28.53 16.28 The above description is merely a preferred composition of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with preferred compositions, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent compositions without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above compositions based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A composition having soothing and repairing effects, characterized in that, It contains the following components by weight: Bark extract of *Bretschneidera sinensis*: 0.7-1.3 parts; PDRN: 0.8-1.1 parts; siRNA: 1-1.3 parts; Mussel adhesive protein: 1.5-2 parts; The PDRN has an average molecular weight of 150-850 kDa; the siRNA has an average molecular weight of 13-14 kDa and is prepared by solid-phase synthesis; the mussel adhesive protein includes Mefp-1 and Mefp-5 types in a weight ratio of 7:2.5-4.

2. The composition with soothing and repairing effects as described in claim 1, characterized in that, It contains the following components by weight: Bark extract of the variegated bellflower tree: 1 part; PDRN: 0.9 copies; siRNA: 1.1 copies; Mussel adhesive protein: 1.7 parts; The PDRN has an average molecular weight of 200 kDa; the siRNA has an average molecular weight of 13.5 kDa; and the mussel adhesive protein comprises Mefp-1 and Mefp-5 in a weight ratio of 7:

3.

3. The use of the composition with soothing and repairing effects as described in claim 1 or 2 in the preparation of cosmetics with soothing and repairing effects.

4. The application as described in claim 3, characterized in that, The dosage form of the cosmetic with soothing and repairing effects includes any one of face cream, lotion, and serum.

5. A serum with soothing and repairing effects, characterized in that, The serum contains 0.1-5 wt% of the composition with soothing and repairing effects as described in claim 1 or 2.

6. The essence as described in claim 5, characterized in that, The serum also contains moisturizers, preservatives, thickeners, pH adjusters, and deionized water.

7. The essence as described in claim 6, characterized in that, The moisturizer is at least one of sodium hyaluronate, glycerin, and squalane.

8. The essence as described in claim 6, characterized in that, The preservative is at least one of p-hydroxyacetophenone, ethylhexylglycerin, and octyl glycol.

9. The essence as described in claim 6, characterized in that, The thickener is at least one of xanthan gum, hydroxyethyl cellulose, ammonium acryloyl dimethyl taurate / VP copolymer, and sodium polyacryloyl dimethyl taurate.

10. The essence as described in claim 6, characterized in that, The pH adjuster is tromethamine.