Composite interference color toner with blue light damage resistance and optical brightening and yellow reduction functions and application thereof

Abstract

The present application relates to the technical field of cosmetics, and discloses a composite interference color powder with the functions of resisting blue light damage and optical lightening and yellow-reducing and application thereof.The color powder comprises titanium dioxide, synthetic fluorphlogopite, silica, hydrogenated polydimethylsiloxane and tin oxide; the color powder has a double-carrier structure composed of flaky synthetic fluorphlogopite and spherical silica, the flaky mica provides mirror reflection and optical interference, and the spherical silica fills the gaps to provide uniform diffuse reflection.The effective concentration of the color powder in cosmetics is 0.5%, the color powder can effectively intercept 450nm high-energy blue light, significantly inhibit blue light-induced oxidative stress, inflammatory response and collagen degradation, and instantly increase the L* value of skin and reduce the b* value, so that the natural light transmission, soft haze and yellow-reducing and lightening effects are achieved.The color powder can be used for preparing skin external preparations such as foundation, sunscreen cream and sunscreen cream.

Description

Technical Field

[0001] This invention relates to the field of cosmetic raw materials and daily chemical products, and in particular to a composite interference color powder with functions of resisting blue light damage and optical brightening and yellowing reduction, and its application. Background Technology

[0002] Blue light (wavelength 400-500 nm), as high-energy visible light, is one of the main sources of "light pollution" in modern life. With the widespread use of electronic devices such as mobile phones, tablets, and LED lighting, people's exposure time to blue light environments has increased significantly. Studies have shown that chronic blue light exposure can accelerate the skin aging process. The mechanism is mainly related to blue light-induced oxidative stress in keratinocytes and fibroblasts, stimulation of melanin production, and mediating the loss of extracellular matrix in dermal cells. Specifically, blue light radiation can activate the burst of reactive oxygen species (ROS) in skin cells, induce increased secretion of inflammatory factors (such as IL-6), and upregulate the expression of matrix metalloproteinases (such as MMP-1, MMP-3, and MMP-9), leading to collagen degradation, ultimately manifesting as dull, yellowish, loose, and wrinkled skin.

[0003] Currently, cosmetic technologies targeting blue light protection mainly focus on two areas: one is relying on plant extracts or bioactive ingredients (such as SOD, peptides, etc.) for antioxidant intervention; the other is using interference pigments for optical modification. However, existing technologies still have significant shortcomings.

[0004] First, the current functional positioning of interference pigments is focused on "visual enhancement," lacking the ability to specifically block blue light. Interference pigments are typically thin, plate-like particles that produce interference colors through a multi-layered structure and have been widely used in personal care compositions to improve skin appearance. For example, commercially available pearlescent particles are often based on synthetic fluorophlogopite, which has a high aspect ratio and good UV shielding properties, capable of protecting against ultraviolet rays and even, to some extent, visible light. However, the core applications of existing interference pigments in cosmetics are still primarily to provide pearlescent luster, color adjustment, and coverage, rather than specifically blocking high-energy blue light in the 400-450 nm wavelength band while simultaneously brightening and reducing yellowing of the skin tone.

[0005] Second, the existing formulations of interference pigments lack an understanding of the synergistic optical effects of the "dual-carrier structure." Some existing technologies mention that interference pigments can be mixed with other fillers (such as spherical silica), but such mixtures are mostly used to improve skin feel or increase transparency. They do not utilize the dual-carrier structure of "sheet mica + spherical silica" to achieve the synergistic effect of "specular reflection" and "diffuse reflection," thereby achieving the dual effects of anti-blue light and optical brightening and yellowing reduction at low concentrations.

[0006] Third, existing interference pigment combinations typically require high addition levels. For example, in some skincare compositions used for skin tone correction, the total amount of interference pigment is usually between 0.1% and 10%. Higher concentrations may lead to adverse effects such as a sticky feel and excessive coverage, and it is difficult to achieve the desired "natural and translucent" makeup effect. Currently, there are no reports of achieving significant blue light protection and brightening / yellowing effects with interference pigments using specific dual-carrier structures at a low effective concentration of 0.5%.

[0007] Therefore, there is an urgent need for a composite interference colorant that combines physical shielding, optical brightening, and biological protection functions, which can achieve highly effective blue light protection, brightening and yellowing reduction with low addition amount, while maintaining a natural light-transmitting skin feel. Summary of the Invention

[0008] The purpose of this invention is to overcome the shortcomings of existing interference pigments, such as limited functionality, lack of directional shielding ability against high-energy visible light (blue light), and difficulty in achieving both anti-blue light damage and optical brightening / yellowing effects at low concentrations. This invention provides a composite interference pigment with both anti-blue light damage and optical brightening / yellowing functions, and its applications. Through a specific "dual-carrier structure," this pigment achieves the technical effects of physically blocking blue light, inhibiting cellular oxidative stress, and significantly brightening / yellowing at a low effective concentration of 0.5%.

[0009] To achieve the above objectives, the present invention adopts the following technical solution: A composite interference colorant with blue light protection and optical brightening / yellowing reduction functions includes titanium dioxide (CI77891), synthetic fluorophlogopite, silica, hydrogenated polydimethylsiloxane, and tin oxide. The colorant has a dual-carrier structure composed of sheet-like synthetic fluorophlogopite and spherical silica. The sheet-like synthetic fluorophlogopite provides specular reflection and optical interference effects, while the spherical silica fills the gaps between the sheet-like particles to provide uniform diffuse reflection. The titanium dioxide is coated on the surface of the synthetic fluorophlogopite, and an interference layer is formed by controlling the coating thickness of the titanium dioxide.

[0010] The core structural feature is that the pigment has a dual-carrier structure composed of flake-shaped synthetic fluorophlogopite and spherical silica. The flake-shaped synthetic fluorophlogopite serves as a substrate in the pigment, providing stable specular reflection and optical interference effects; the spherical silica fills the gaps between the flake-shaped particles, providing uniform diffuse reflection, reducing abrupt reflections, and simultaneously increasing the smoothness and soft-focus effect of the system.

[0011] As a preferred technical solution, the concentration of the pigment in cosmetics or topical skin preparations is 0.5% by mass.

[0012] As a preferred technical solution, the thickness of the sheet-like synthetic fluorophlogopite is 100-1500 nm, and the average diameter of the individual particles in the longest direction is 5-75 μm; the average particle size of the spherical silica is 0.1-25 μm.

[0013] The present invention also provides a topical skin preparation comprising the above-mentioned composite interference pigment, wherein the topical skin preparation is selected from one of creams, lotions, serums, foundations, or makeup products. The composite interference pigment accounts for 0.5% of the total mass of the topical skin preparation.

[0014] As a preferred technical solution, the topical skin preparation comprises the following components by mass fraction: 65.55% water, 3% methyl gluceth-20, 10% glycerin, 2% PEG / PPG-17 / 6 copolymer, 6% 1,3-butanediol, 4% polyethylene glycol-8, 0.4% p-hydroxyacetophenone, 0.4% 1,2-hexanediol, 0.02% disodium EDTA, 0.2% allantoin, 0.1% sodium polyacrylate, 0.3% polyacrylate crosspolymer-6, 0.15% acrylate / C10-30 alkanol acrylate crosspolymer, 0.1% xanthan gum, 1.5% PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, 0.18% tromethamine, 1.5% caprylic / capric glyceride, 3% pentaerythritol tetra(ethylhexanoate), 0.5% polydimethylsiloxane, 0.5% jojoba oil, 0.1% tocopheryl acetate, and 0.5% of the above-mentioned composite interference pigment.

[0015] This invention further protects the application of the aforementioned composite interference pigment in the preparation of cosmetics for resisting blue light damage and / or brightening and reducing yellowing. The amount of the composite interference pigment added to the cosmetic is 0.5% by mass; the cosmetic includes, but is not limited to, foundation, primer, or sunscreen; the blue light specifically refers to high-energy visible light with a wavelength of 400–450 nm.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: Synergistic Effect of Dual-Carrier Structure: This invention utilizes a dual-carrier structure design of "sheet-like synthetic fluorophlogopite + spherical silica." The high aspect ratio of the sheet-like structure provides stable interference reflection, while the spherical silica fills the gaps to generate uniform diffuse reflection, achieving "microstructure color control" at the optical level. This unique physical structure effectively blocks high-energy blue light in the 400–450 nm range and improves skin dullness caused by light scattering. Excellent anti-blue light and brightening / yellowing effects are achieved with an extremely low addition amount (0.5%).

[0017] Significant in vitro cell protection effect: 450nm blue light (20mW / cm²) 2Experiments involving 30-minute irradiation of HACAT epidermal cells and HSF fibroblasts showed that the present invention achieved a 96.4% protection rate against IL-6 inflammatory factors and a 99.8% protection rate against SOD antioxidant enzymes in HACAT cells; and a 94.4% protection rate against MMP-1, a 93.6% protection rate against MMP-3, a 98.6% protection rate against MMP-9, a 74.8% protection rate against type I collagen, and a 60.3% protection rate against type III collagen in HSF fibroblasts. The overall average protection rate reached 88.3%, and the ROS level in cells irradiated with blue light, as detected by the DCFH-DA probe, was almost no different from that in the blank control group, significantly superior to the basal membrane group and the positive control group.

[0018] Immediate optical brightening and yellowing-reducing effects (human testing): A single-sided facial application test conducted by 34 healthy Chinese female subjects using a sample containing 0.5% of the colorant from this invention for 5-15 minutes, as determined by the authoritative third-party institution SGS, showed a significant increase in skin color L* value by 1.76% (brightening), a significant decrease in skin color b* value by 9.52% (yellowing reduction), a significant increase in skin ITA° value by 13.01% (lightening of skin tone), and a significant increase in skin radiance by 24.61%. In the subjects' self-assessment, 100% of the subjects agreed that the product had the effects of reducing yellowing, brightening, and providing a natural, seamless finish.

[0019] Excellent skin feel and good compatibility: The color powder of this invention, through a specific combination of forms, not only has good optical effects, but also has a makeup effect of "natural light transmission and soft matte finish". It is smooth and adheres well without showing texture, breaking the technical prejudice of traditional physical concealer powders that "only high concentration is effective, but it looks fake and heavy". It provides an innovative raw material for color cosmetics and skin care products with controllable luster and natural radiance. Attached Figure Description

[0020] Figure 1 The images show a comparison of ROS fluorescence microscopy in each group of cells during the blue light resistance experiment of this invention (scale bar 100μm). In the images, A is the blank control group, B is the base membrane group, C is the positive control group, and D is the 0.5% blue membrane group (Sample). Figure 2 This is a comparison image of the face of the subject in the human efficacy test of this invention using VISIA CR 5.0 (before use and 5-15 minutes after makeup application). Detailed Implementation

[0021] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below with reference to specific embodiments.

[0022] Example 1: Preparation of composite interference pigments This embodiment provides a composite interference colorant with functions of resisting blue light damage and optical brightening and yellowing reduction, comprising titanium dioxide (CI 77891), synthetic fluorophlogopite, silica, hydrogenated polydimethylsiloxane, and tin oxide. The colorant has a dual-carrier structure composed of flake-like synthetic fluorophlogopite and spherical silica.

[0023] This invention does not limit the specific preparation method of the interference pigment; those skilled in the art can prepare it using conventional methods. A conventional wet coating process can be used to coat titanium dioxide onto the surface of synthetic fluorophlogopite. The mechanism of interference light formation mainly involves controlling the thickness of the titanium dioxide coating to achieve a specific synergistic effect of optical interference and diffuse reflection. The pigment achieves a makeup effect that balances aesthetics and functionality through complementary particle shapes and optical synergy; its mechanism is shown in Table 1. Table 1. Mechanism of Action of Dual-Carrier Structure ; Example 2: A topical skin preparation containing 0.5% composite interference pigment Prepare test samples (total mass 100%) according to the components and mass fractions shown in Table 2.

[0024] Table 2. Composition of Test Samples ; ; Preparation process: Add the A-phase raw materials (p-hydroxyacetophenone, 1,3-butanediol, 1,2-hexanediol) into the main pot, heat to 78℃-82℃, stir until completely dissolved, and then cool to room temperature.

[0025] Add the B phase raw materials (glycerol, acrylate / C10-30 alkanol acrylate crosspolymer, xanthan gum, sodium polyacrylate, polyacrylate crosspolymer-6) into the cooled main pot and stir until completely dispersed and uniform.

[0026] Add the C-phase raw materials (water, PEG / PPG-17 / 6 copolymer, disodium EDTA, allantoin, polyethylene glycol-8, methyl gluceth-20, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerol) to the mixing bowl and stir slowly until completely transparent.

[0027] Pre-dissolve the D-phase raw materials (tromethamine and water) in an external container, and slowly add them to the main pot while stirring until they are evenly mixed.

[0028] Mix the E-phase raw materials (glyceryl caprylate, pentaerythritol tetra(ethylhexanoate), polydimethylsiloxane, jojoba oil, and tocopheryl acetate) and heat to 78℃-82℃ until completely dissolved. Slowly add the mixture to the main pot and homogenize and emulsify it evenly.

[0029] Cool the mixture to below 40°C, slowly add the composite interference pigment prepared in Example 1, and stir until homogeneous. Degas under vacuum, measure pH and appearance, and discharge to obtain the finished product.

[0030] Example 3: Blue Light Blocking Performance Test Using a CS-700 spectrophotometer from ColorSpectrum Technology (Zhejiang) Co., Ltd., three parallel measurements were performed on the base film group and the topical skin preparation containing 0.5% of the pigment of this invention, and the average value was taken as the transmittance data of the group. The average transmittance results of each group in the 400nm-450nm wavelength range are shown in Table 3.

[0031] Table 3. Test results of transmittance (%) of different samples in the 400–450 nm wavelength range. ; The results showed that the base film group had an average transmittance of approximately 88.3% at 450 nm, while the 0.5% blue film group of the present invention had an average transmittance of approximately 59.3% at 450 nm, representing a significant reduction of approximately 30% in transmittance in the 400-450 nm wavelength range. This indicates that the pigment of the present invention has excellent physical blocking ability for high-energy blue light. This performance supports the protective application for high-energy visible light with wavelengths of 400-450 nm as described in claim 10.

[0032] Example 4: In vitro cell-based blue light protection experiment (I) Experimental Materials and Methods 1. Cells and main reagents HACAT human immortalized epidermal cells and HSF human skin fibroblasts were purchased from Qisai Biotechnology (product numbers: QS-H019, QS-Q101).

[0033] The reagent kit information used to detect various indicators in this embodiment is as follows: Human interleukin-6 (IL-6) ELISA kit (Quanzhou Leda Qibo Biotechnology Co., Ltd., catalog number: LDQB-A-10377); Superoxide dismutase (SOD) activity assay kit (Solarbio, catalog number: CA1410; measured at 450 nm using the WST-8 method); Human type I collagen (Col I) ELISA kit (Quanzhou Leda Qibo Biotechnology Co., Ltd., catalog number: LDQB-A-10154); Human type III collagen (Col III) ELISA kit (Quanzhou Leda Qibo Biotechnology Co., Ltd., catalog number: LDQB-A-10050); Human matrix metalloproteinase 1 (MMP-1) ELISA kit (Quanzhou Leda Qibo Biotechnology Co., Ltd., catalog number: LDQB-A-10746). Human matrix metalloproteinase 3 (MMP-3) ELISA kit (Quanzhou Leda Qibo Biotechnology Co., Ltd., catalog number: LDQB-A-10753); Human matrix metalloproteinase 9 (MMP-9) ELISA kit (Quanzhou Leda Qibo Biotechnology Co., Ltd., catalog number: LDQB-A-10756). Reactive oxygen species (ROS) detection kit (Solarbio, catalog number: CA1410).

[0034] 2. Cell Culture and Grouping After seeding the cells into culture plates, they were divided into the following groups: Control group: Cells were not treated and cultured normally without blue light irradiation; Model control group: Irradiated with blue light, separated by a 96-well plate cover; Base: The base sample is coated on the cap surface of the 96-well plate and irradiated with blue light; Positive control group: Irradiated with blue light, with a positive membrane in between; 0.5% Blue Film Sample: A blue film containing 0.5% of the sample of the present invention was applied to the surface of the cap of a 96-well plate and then irradiated with blue light.

[0035] Blue light irradiation conditions: 450nm, 20mW / cm 2 Irradiate for 30 minutes, then continue culturing for 24 hours.

[0036] 3. In this embodiment, IL-6, Col I, Col III, MMP-1, MMP-3, and MMP-9 were all measured using a one-step sandwich enzyme-linked immunosorbent assay (ELISA) with double antibodies, and SOD was measured using the WST-8 method. All assays were performed strictly in accordance with the instructions of the respective kits.

[0037] The principle of SOD activity detection is as follows: SOD can remove superoxide anions, thereby inhibiting the reaction of WST-8 with superoxide anions to generate water-soluble formazan dye (which has maximum absorption at 450nm). The darker the color of the reaction solution, the lower the SOD activity, and vice versa.

[0038] The detection principle of the ELISA kit is as follows: Samples, standards, and HRP-labeled detection antibodies are sequentially added to microwells pre-coated with capture antibodies. After incubation and thorough washing, the kit is incubated with the substrate TMB for color development, which turns yellow under acidic conditions. The absorbance (OD value) is measured at 450 nm using a microplate reader (SPECTRAMAXiD3) to calculate the sample concentration.

[0039] The standard curve equations for each indicator all exhibit good linearity (R²). 2 > 0.99).

[0040] (II) Detection methods and standard curves In this embodiment, all indicators were detected using the ELISA / WST-8 method. The standard curves for each indicator showed good linearity (R0). 2 All are greater than 0.99. For example, the standard curve equation for type III collagen is Y = 0.01325*X + 0.09307, R... 2 =0.99).

[0041] (III) Detection results of IL-6 inflammatory factor and SOD antioxidant enzyme in HACAT cells The results are shown in Table 4.

[0042] Table 4. Results of IL-6 and SOD detection in HACAT cells ; Calculations show that the present invention has an inhibition and protection rate of 96.4% for IL-6 and a protection rate of 99.8% for SOD.

[0043] (iv) Results of HSF cell collagen and matrix metalloproteinase (MMP) detection The results are shown in Tables 5 and 6.

[0044] Table 5 Results of HSF cell type I and type III collagen detection ; Calculations show that the present invention provides 74.8% protection for type I collagen and 60.3% protection for type III collagen.

[0045] Table 6. Results of MMP-1, MMP-3, and MMP-9 detection in HSF cells ; Conclusion: The protection rate of this invention against the three MMPs is above 93.6%, which is superior to or equivalent to the basic membrane group. (V) Results of fluorescence microscopy detection of ROS (reactive oxygen species) The DCFH-DA probe was used to detect the ROS levels in each group of cells (e.g., Figure 1 As shown, Figure 1 The image shown only represents the blank control group, the basal membrane group, the positive control group, and the 0.5% blue membrane group. The results showed that the blank control group (A) showed almost no green fluorescence; the basal membrane group (B) and the positive control group (C) both showed varying degrees of green fluorescence; while the green fluorescence in the 0.5% blue membrane group (D) was almost absent, showing no significant difference from the blank control group (A). This indicates that the present invention can completely block the generation of reactive oxygen species induced by blue light, and its antioxidant effect is significantly better than that of the basal membrane group and the positive control group.

[0046] (vi) Conclusion on the overall protection rate The average protection rate of HACAT cells was 98.1%, the average protection rate of HSF cells was 84.3%, and the overall average protection rate reached 88.3%.

[0047] Safety evaluation: The present invention has passed the toxicological test reports of acute oral toxicity test, skin sensitization test, and skin phototoxicity test. The test results all meet the cosmetic safety technical specifications, proving that the 0.5% blue film group of the present invention has no cytotoxicity and has high safety.

[0048] Example 5: Human Body Brightening and Yellowing Reduction Efficacy Test (I) Test Plan and Instrument Principles 1. Assessment Summary and Subjects Evaluation sample: A sample containing 0.5% (m / m) of the composite interference pigment of this invention.

[0049] Control sample: matrix.

[0050] Participants: A total of 34 valid participants who completed the assessment were healthy Chinese women aged 27 to 58 years, with a mean age of 41.38 ± 8.54 years.

[0051] Instructions for use: The subject should use the evaluation sample on one side of the face and the control sample on the other side. Apply 0.3g of sample to the face each time and gently pat it evenly with your fingertips.

[0052] Evaluation period: before using the sample (T0), 5-15 minutes after makeup application (Timm).

[0053] 2. Evaluation Instrument Principles (1) VISIA CR 5.0 (Canfield): Used for facial image acquisition.

[0054] (2) Colorimeter CL400 (Courage + Khazaka electronic GmbH): Skin color meter. The probe emits LED light, which is scattered in all directions. Some of the light passes through the skin surface, and some is scattered by the skin. The probe measures the reflected light and corrects the original data through a special color matrix. The final value is expressed as XYZ value and can be calculated as an exponential value in L*a*b and RGB form. A larger L* value indicates a brighter skin color; a smaller a* value indicates less redness; a smaller b* value indicates less yellowness. The Individual Type Angle (ITA°) is a parameter that characterizes human skin color using skin L*a*b color space data. The calculation formula is: ITA° = (tan -1 ((L-50) / b*)) × 180 / π, the larger the measured value, the lighter the skin color.

[0055] (3) Glossymeter GL200 (Courage + Khazaka electronic GmbH): Skin gloss meter. It measures the glossiness of different skin types by testing the reflected and scattered light on the skin surface. A higher skin gloss measurement indicates increased skin glossiness.

[0056] 3. Data Statistical Methods Data were analyzed using SPSS 28.0. Descriptive statistics were performed on the measurements for each assessment region. The Shapiro-Wilke test was used to test the normality of the assessment data (significance level α = 0.05). If the data were normally distributed, a paired t-test was used; otherwise, a rank-sum test was used. The self-assessment questionnaire was analyzed using a binomial test, with two-tailed tests at a significance level of α = 0.05. Rank-sum tests were used for ordinal data.

[0057] (II) Instrument test results: as shown in Table 7 Table 7. Change rate and significance analysis of human skin color and gloss. ; Note: Rate of change = (Measurement after sample use - Measurement before sample use) ÷ Measurement before sample use × 100% (III) Results of self-assessment by the participants 1. Individual skin condition (rate of change) Subjects' self-assessment (their own skin condition, scoring scale: 0 to 9 points, the lower the score, the better the skin condition). The rate of change of all indicators on the sample side was significantly better than that on the control side. The rate of change (negative values ​​represent improvement) data are as follows: Overall skin radiance: Sample -48.03%, Control -24.89%; Skin radiance: Sample -49.12%, Control -25.44%; Skin tone evenness: Sample -49.19%, Control -22.86%; Skin dullness level: Sample -47.62%, Control -24.57%; Yellowing of skin: Sample -46.35%, Control -23.28%; Overall skin brightness: Sample -49.13%, Control -26.09%.

[0058] (Note: All of the above items showed significant differences "compared to the sample" and "compared to the control".) 2. Subject agreement 5-15 minutes after makeup application, 100% of participants agreed that their skin's yellowing was reduced; 100% agreed that their skin's dullness was reduced; 100% agreed that their skin's radiance was improved; 100% agreed that their skin appeared smoother; 100% agreed that their makeup looked more natural; and 100% agreed that their skin appeared lighter and more luminous. A binomial test showed significant differences in the consensus rates for all criteria (P<0.05).

[0059] (iv) Conclusion Combination Figure 2 As can be seen from the VISIA image and the data in Table 7, the present invention has a significant effect on instantly brightening and improving the yellowness of the skin.

[0060] Example 6: Skin Feel Evaluation Test Take 0.01g of sample and apply it evenly to the skin surface. Observe it with a high-powered camera and measure the transparency and coefficient of friction. The results are shown in Table 8.

[0061] Table 8 Comparison of Skin Feel and Transparency of Different Powders ; Compared to titanium dioxide, silica, or single synthetic fluorophlogopite, the pigments of this invention exhibit superior transparency (93.5%) and a soft matte finish, with the lowest dynamic / static coefficient of friction. This is due to the "sheet-like mica + spherical silica" dual-carrier structure described in Table 1 above. The silica particles fill the gaps in the sheet-like mica, uniformly scattering light and reducing the abrupt reflections that are easily produced by single mica, thus achieving a high-end makeup effect of "natural light transmission and soft matte finish," while also being smooth and adherent without showing any texture.

[0062] Example 7: Mechanism of Action Analysis As can be seen from the above embodiments, the composite interference color powder of the present invention achieves anti-blue light and brightening / yellowing effects through multiple synergistic pathways: ①Physical barriers; ② Inhibit oxidative stress; ③ Suppress the inflammatory response; ④ Inhibit collagen degradation; ⑤ Maintain collagen synthesis; ⑥ Optical brightening and yellowing reduction.

[0063] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A composite interference pigment with functions of resisting blue light damage and optical brightening and yellowing reduction, characterized in that, The pigment comprises titanium dioxide, synthetic fluorophlogopite, silica, hydrogenated polydimethylsiloxane, and tin oxide. The pigment has a dual-carrier structure consisting of flake-shaped synthetic fluorophlogopite and spherical silica, wherein the flake-shaped synthetic fluorophlogopite provides specular reflection and optical interference effects, and the spherical silica fills the gaps between the flake-shaped particles to provide uniform diffuse reflection. The titanium dioxide is coated on the surface of the synthetic fluorophlogopite, and an interference layer is formed by adjusting the coating thickness of the titanium dioxide.

2. The composite interference pigment according to claim 1, characterized in that, The concentration of the pigment in cosmetics or topical skin preparations is 0.5% by mass.

3. The composite interference pigment according to claim 1, characterized in that, The thickness of the sheet-like synthetic fluorophlogopite is 100–1500 nm, and the average diameter of the individual particles along the longest direction is 5–75 μm; the average particle size of the spherical silica is 0.1–25 μm.

4. A topical skin formulation comprising the composite interference pigment according to any one of claims 1-3, characterized in that, The topical skin preparation is selected from one of the following: cream, lotion, serum, foundation, or makeup products.

5. The topical skin preparation according to claim 4, characterized in that, The composite interference pigment accounts for 0.5% of the total mass of the topical skin preparation.

6. The topical skin preparation according to claim 4, characterized in that, The topical skin preparation comprises the following components by mass fraction: Water content: 65.55%; Methyl glucetol polyether-20 3%; 10% glycerin; 2% PEG / PPG-17 / 6 copolymer; 1,3-Butanediol 6%; Polyethylene glycol - 84%; p-Hydroxyacetophenone 0.4%; 1,2-Hexanediol 0.4%; Disodium EDTA 0.02%; Allantoin 0.2%; Sodium polyacrylate 0.1%; Polyacrylate crosspolymer - 6 0.3%; Acrylic (ester) / C10-30 alkanol acrylate crosspolymer 0.15%; Xanthan gum 0.1%; PEG / PPG / Polybutylene Glycol-8 / 5 / 3 Glycerin 1.5%; Tromethamine 0.18%; Caprylic / capric triglyceride 1.5%; Pentaerythritol tetra(ethylhexanoate) ester 3%; Polydimethylsiloxane 0.5%; Jojoba oil 0.5%; Tocopheryl acetate 0.1%; And 0.5% by mass of the composite interference pigment as described in any one of claims 1-3.

7. The use of the composite interference pigment according to any one of claims 1 to 3 in the preparation of cosmetics for resisting blue light damage and / or brightening and reducing yellowing.

8. The application according to claim 7, characterized in that, The amount of the composite interference pigment added to the cosmetic product is 0.5% by mass.

9. The application according to claim 7, characterized in that, The cosmetic product in question is foundation, primer, or sunscreen.

10. The application according to claim 7, characterized in that, The blue light is high-energy visible light with a wavelength of 400-450nm.

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