A compact radioactive mother liquor dispensing system and method

Abstract

The present application relates to the field of radioactive mother liquor, and discloses a compact radioactive mother liquor dispensing system and method, which comprises a lifting mechanism, a syringe, an activity meter, inlet and outlet pipelines, a mother liquor bottle, a dilution bottle, a mother liquor branch, a dilution branch, a pinch valve, an air sensor and a control module. The control module can control the operating state of the dilution branch and the mother liquor branch through the pinch valve. The mother liquor in the mother liquor bottle is diluted with the dilution liquid in the dilution bottle, and the diluted mother liquor in the mother liquor bottle and the dilution liquid in the dilution bottle are transported into the syringe for mother liquor dispensing. The automatic operation of mother liquor dilution and dispensing is realized, manual operation of the staff for mother liquor dilution and dispensing in a radioactive environment is reduced, the risk of radioactive injury is avoided, high-precision mother liquor dispensing is realized, the syringe after dispensing is loaded into a tungsten sleeve, and the degree of automation is high.

Description

Technical Field

[0001] This invention relates to the field of radioactive mother liquor in medicine, and more particularly to a compact radioactive mother liquor dispensing system and method. Background Technology

[0002] With the development of science and technology, radiotherapy technology is constantly improving.

[0003] The hospital prepares for the procurement, dilution, and repackaging of radiotherapy mother fluids. Specifically, based on the total activity of the mother fluid needed that day, the hospital procures pre-filled radiotherapy mother fluids from the pharmaceutical company. The liquid, packaged in vials, is placed in sealed lead containers and transported to the hospital. Hospital staff then place the sealed lead containers in a shielded box, open the containers, and proceed with the dilution and repackaging of the mother fluid.

[0004] However, the mother liquor is radioactive. Workers dilute and dispense the mother liquor manually, which exposes them to radiation for extended periods, posing a high risk of radiation-related harm. Summary of the Invention

[0005] This invention provides a compact radioactive mother liquor dispensing system and method to address the shortcomings of related technologies where manual operation of mother liquor dilution and dispensing by workers poses a high risk of radioactive injury. The system automates the mother liquor dilution and dispensing process, reducing manual operation and thus minimizing the risk of radioactive injury.

[0006] In a first aspect, the present invention provides a compact radioactive mother liquor dispensing system, comprising: Lifting mechanism; The syringe is vertically suspended on the lifting mechanism, with its inlet and outlet facing upwards; An activity meter is installed at a first predetermined position on the syringe lifting path to monitor the activity of the mother liquor in the syringe. Inlet and outlet lines, one end of which is connected to the common inlet and outlet end of the syringe; Mother liquor bottle and dilution bottle, the bottles contain mother liquor and diluent respectively; The system includes a mother liquor branch and a dilution branch. One end of the mother liquor branch is connected to the common inlet and outlet of the mother liquor bottle, and one end of the dilution branch is connected to the outlet of the dilution bottle. The other end of the dilution branch and the other end of the mother liquor branch are common ends, and the common ends are connected to the other ends of the inlet and outlet pipelines. A pinch valve is installed on the dilution branch and the mother liquor branch to switch the open and closed states of the dilution branch and the mother liquor branch; An air sensor is installed on the inlet and outlet pipelines; The control module is communicatively connected to the lifting mechanism, the dilution branch, the mother liquor branch, the clamp valve, and the air sensor. It is used to dilute the mother liquor in the mother liquor bottle through the dilution branch and the mother liquor branch, and to dispense the diluted mother liquor into the syringe.

[0007] Optionally, the dilution branch includes: The first peristaltic pump has its input pipe connected to the output end of the dilution bottle, and the output end is the common end of the dilution branch and the mother liquor branch.

[0008] Optionally, the mother liquor branch includes: A spacer is fitted onto the outer wall of the mother liquor bottle; The shielding groove contains both the mother liquor bottle and the spacer. The venting needle has its tip inserted into the mother liquor bottle through the bottle cap and is in the gas inside the bottle, while the needle seat is located outside the mother liquor bottle. A liquid extraction needle, the tip of which is inserted into the mother liquor bottle through the cap and into the liquid inside the bottle; The second peristaltic pump has an input pipe connected to the needle seat of the aspiration needle, and an output end that is the common end of the dilution branch and the mother liquor branch.

[0009] Optionally, the first control end of the pinch valve on the dilution branch is located on the pipeline between the common end and the first peristaltic pump; The clamp valve is located at the second control end of the mother liquor branch, on the pipeline between the common end and the second peristaltic pump.

[0010] Optionally, the lifting mechanism includes: Elevator; The suspended platform is installed on the lifting device; The syringe is vertically suspended on the basket, with the liquid inlet and outlet of the syringe facing upwards.

[0011] Optionally, the system further includes: A tungsten sleeve is installed on the lifting device and located at a second predetermined position on the lifting path of the syringe. The first predetermined position is higher than the second predetermined position. It is used to house the pre-packaged syringe.

[0012] In a second aspect, the present invention provides a method for dispensing radioactive mother liquor, which implements the compact radioactive mother liquor dispensing system of the first aspect above or any corresponding embodiment thereof, the system including a lifting mechanism, a syringe, an activity meter, inlet and outlet pipelines, a mother liquor bottle, a dilution bottle, a mother liquor branch, a dilution branch, a clamp valve, an air sensor and a control module; The method includes: The control module delivers a set volume of diluent into the syringe based on the dilution bottle; The control module delivers the set volume of diluent from the syringe to the mother liquor bottle to dilute the mother liquor in the mother liquor bottle; The control module moves the syringe into the activity meter via the lifting mechanism; The control module continuously delivers the diluted mother liquor from the mother liquor bottle to the syringe and monitors the activity of the mother liquor in the syringe using the activity meter until the activity of the mother liquor in the syringe reaches the set activity range.

[0013] Thirdly, the present invention provides a computer device, comprising: a memory and a processor, the memory and the processor being communicatively connected to each other, the memory storing computer instructions, and the processor executing the computer instructions to perform the radioactive mother liquor dispensing method of the first aspect or any corresponding embodiment described above.

[0014] Fourthly, the present invention provides a computer-readable storage medium storing computer instructions for causing a computer to execute the radioactive mother liquor dispensing method of the first aspect or any corresponding embodiment described above.

[0015] The present invention provides a compact radioactive mother liquor dispensing system and method. The system includes a lifting mechanism, a syringe, an activity meter, inlet and outlet pipelines, a mother liquor bottle, a dilution bottle, a mother liquor branch, a dilution branch, a clamp valve, an air sensor, and a control module. The control module can control the operating status of the dilution branch and the mother liquor branch through the clamp valve. The diluent in the dilution bottle is used to dilute the mother liquor in the mother liquor bottle, and the diluted mother liquor in the mother liquor bottle and the diluent in the dilution bottle are delivered to the syringe for mother liquor dispensing. This realizes the automated operation of mother liquor dilution and dispensing, reduces the manual operation of mother liquor dilution and dispensing by personnel in a radioactive environment, avoids the risk of radiation damage, and can also achieve high-precision mother liquor dispensing. After dispensing, the syringe is inserted into a tungsten sleeve, and the automation integration is high. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in this invention or related technologies, the accompanying drawings used in the description of the embodiments or related technologies will be briefly introduced below. Obviously, the accompanying drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of a compact radioactive mother liquor dispensing system provided in an embodiment of the present invention; Figure 2 A three-dimensional model view of a compact radioactive mother liquor dispensing system provided in an embodiment of the present invention; Figure 3 A perspective view of a compact radioactive mother liquor dispensing system provided in an embodiment of the present invention; Figure 4 A front view of a compact radioactive mother liquor dispensing system provided in an embodiment of the present invention; Figure 5 A top view of a compact radioactive mother liquor dispensing system provided in an embodiment of the present invention; Figure 6 A flowchart of a method for dispensing radioactive mother liquor provided in an embodiment of the present invention; Figure 7 This is a schematic diagram of a radioactive mother liquor dispensing operation interface provided in an embodiment of the present invention; Figure 8 This is a schematic diagram of a dispensing operation interface containing ice force information provided in an embodiment of the present invention; Figure 9 A schematic diagram of the structure of a control module provided in an embodiment of the present invention; Figure 10 This is a schematic diagram of the structure of a computer device provided in an embodiment of the present invention.

[0018] The correspondence between the attached icon numbers and the devices is as follows: 01-Lifting device; 02-Tungsten sleeve; 03-Activity meter; 04-Instrument; 05-Basket; 06-Air sensor; 07-Pinch valve; 08-Dilution branch; 09-Mother liquor branch; 10-First peristaltic pump; 11-Second peristaltic pump; 12-Dilution bottle; 13-September; 14-Aspiration needle; 15-Mother liquor bottle; 16-Exhaust needle; 17-Pipeline; 18-Shielding tank. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0020] The existing technology relies on manual operation for the dilution, extraction, and injection of the mother liquor into the human body, with the entire process being consistent with that of conventional pharmaceuticals. However, the mother liquor is radioactive, and long-term exposure to radiation during operation can lead to radiation damage. Furthermore, manual operation cannot guarantee the accuracy of the mother liquor's activity. Fully automated dispensing equipment solves the problem of achieving dispensing accuracy that is impossible manually.

[0021] The following is combined Figure 1 The present invention describes a compact radioactive mother liquor dispensing system.

[0022] like Figure 1 As shown, this embodiment proposes a first compact radioactive mother liquor dispensing system, which includes: Lifting mechanism; Syringe 04 is vertically suspended on the lifting mechanism, with the common inlet and outlet facing upwards; The activity meter 03 is set at the first set position on the lifting path of the syringe 04 and is used to monitor the activity of the mother liquor in the syringe 04. Inlet / outlet line 17, one end of which is connected to the common inlet / outlet end of syringe 04; Mother liquor bottle 15 and dilution bottle 12, each containing mother liquor and diluent respectively; Mother liquor branch 09 and dilution branch 08, one end of the mother liquor branch 09 is connected to the common inlet and outlet end of the mother liquor bottle 15, and one end of the dilution branch 08 is connected to the outlet end of the dilution bottle 12; the other end of the dilution branch 08 and the other end of the mother liquor branch 09 are common ends, and the common ends are connected to the other end of the inlet and outlet pipeline 17. Pinch valve 07 is installed on dilution branch 08 and mother liquor branch 09 to switch the open and closed states of dilution branch 08 and mother liquor branch 09. Air sensor 06 is installed on inlet / outlet pipeline 17; The control module is connected to the lifting mechanism, dilution branch 08, mother liquor branch 09, clamp valve 07 and air sensor 06. It is used to deliver diluted mother liquor to syringe 04 based on dilution branch 08 and mother liquor branch 09 so that the activity of mother liquor in syringe 04 reaches the set activity range.

[0023] The lifting mechanism includes: Lifting device 01; Suspended platform 05 is installed on lifting device 01; The syringe 04 is vertically suspended on the basket 05, with the liquid inlet and outlet of the syringe 04 facing upwards.

[0024] Among them, dilution branch 08 includes: The first peristaltic pump 10 has its input pipe connected to the output end of the dilution bottle 12, and the output end is the common end of the dilution branch 08 and the mother liquor branch 09.

[0025] Specifically, mother liquor branch 09 includes: The spacer 13 is fitted onto the outer wall of the mother liquor bottle 15; The shielding tank 18, the mother liquor bottle 15 and the spacer 13 are all located inside the shielding tank 18; The exhaust needle 16 has its tip inserted into the mother liquor bottle 15 through the cap and is in the gas inside the bottle, while the needle seat is located outside the mother liquor bottle 15. The liquid extraction needle 14 has its tip inserted into the mother liquor bottle 15 through the cap and into the liquid inside the bottle. The second peristaltic pump 11 has its input end pipe connected to the needle seat end of the suction needle 14, and its output end is the common end of the dilution branch 08 and the mother liquor branch 09.

[0026] Among them, the first control end of the pinch valve 07 on the dilution branch 08 is located on the pipeline between the common end and the first peristaltic pump 10; The second control end of the pinch valve 07 on the mother liquid branch 09 is located on the pipeline between the common end and the second peristaltic pump 11.

[0027] Specifically, the aforementioned system also includes: The tungsten sleeve 02 is installed on the lifting device 01 and is located at the second set position on the lifting path of the syringe 04. The first set position is higher than the second set position. It is used to house the pre-packaged syringe 04.

[0028] Specifically, the control module can first determine the volume of diluent to be input into the mother liquor bottle 15, then open the dilution branch 08 through the clamp valve 07 and close the mother liquor branch 09, extracting the corresponding volume of diluent from the dilution bottle 12 and inputting it into the syringe 04. Afterwards, the control module can close the dilution branch 08, open the mother liquor branch 09, extract the diluent from the syringe 04, and deliver it to the mother liquor bottle 15 for mother liquor dilution.

[0029] Afterwards, the control module can continue to control the operating status of the dilution branch 08 and the mother liquor branch 09 through the clamp valve 07, extract the diluted mother liquor in the mother liquor bottle 15 and the diluted liquid in the dilution bottle 12, and deliver them to the syringe 04 until the activity of the mother liquor in the syringe 04 reaches the set activity range, thereby realizing the high-precision dispensing of mother liquor by the syringe 04.

[0030] It should be noted that the schematic diagram of the compact radioactive mother liquor dispensing system is as follows: Figure 2 As shown, the product's 3D view, front view, and top view are respectively as follows: Figures 3 to 5 As shown.

[0031] The compact radioactive mother liquor dispensing system proposed in this embodiment includes a lifting mechanism, a syringe 04, an activity meter 03, inlet and outlet pipelines 17, a mother liquor bottle 15, a dilution bottle 12, a mother liquor branch 09, a dilution branch 08, a clamp valve 07, an air sensor 06, and a control module. The control module can control the operating status of the dilution branch 08 and the mother liquor branch 09 through the clamp valve 07. The mother liquor in the mother liquor bottle 15 is diluted with the diluent in the dilution bottle 12, and the diluted mother liquor in the mother liquor bottle 15 and the diluent in the dilution bottle 12 are delivered to the syringe 04 for mother liquor dispensing. This realizes the automated operation of mother liquor dilution and dispensing, reduces the manual operation of the staff for mother liquor dilution and dispensing in the radioactive environment, avoids the risk of radiation damage, and can also achieve high-precision mother liquor dispensing. After dispensing, the syringe 04 is loaded into the tungsten sleeve 02, with a high degree of automation integration.

[0032] like Figure 6 As shown, this embodiment proposes a method for dispensing radioactive mother liquor. This method is applied to any of the aforementioned compact radioactive mother liquor dispensing systems. The system includes a lifting mechanism, a syringe 04, an activity meter 03, inlet / outlet lines 17, a mother liquor bottle 15, a dilution bottle 12, a mother liquor branch 09, a dilution branch 08, a clamp valve 07, an air sensor 06, and a control module. Wherein: Syringe 04 is vertically suspended on the lifting mechanism, with the common inlet and outlet facing upwards; The activity meter 03 is set at the first set position on the lifting path of the syringe 04 and is used to monitor the activity of the mother liquor in the syringe 04. Inlet / outlet line 17, one end of which is connected to the common inlet / outlet end of syringe 04; Mother liquor bottle 15 and dilution bottle 12, each containing mother liquor and diluent respectively; Mother liquor branch 09 and dilution branch 08, one end of the mother liquor branch 09 is connected to the common inlet and outlet end of the mother liquor bottle 15, and one end of the dilution branch 08 is connected to the outlet end of the dilution bottle 12; the other end of the dilution branch 08 and the other end of the mother liquor branch 09 are common ends, and the common ends are connected to the other end of the inlet and outlet pipeline 17. Pinch valve 07 is installed on dilution branch 08 and mother liquor branch 09 to switch the open and closed states of dilution branch 08 and mother liquor branch 09. Air sensor 06 is installed on inlet / outlet pipeline 17; The control module is connected to the lifting mechanism, dilution branch 08, mother liquor branch 09, clamp valve 07 and air sensor 06. It is used to dilute the mother liquor in the mother liquor bottle 15 through the dilution branch 08 and mother liquor branch 09, and dispense the diluted mother liquor into the syringe 04.

[0033] Specifically, the above method includes the following steps: S601, the control module delivers a set volume of diluent to the syringe 04 based on the dilution bottle 12.

[0034] Specifically, in this embodiment, the relevant equipment and pipelines can be connected and installed. After the equipment and pipelines are installed, the syringe 04 is hung on the basket 05, and the system performs a self-test. After the self-test is completed, the mother liquor is diluted.

[0035] In this embodiment, when diluting the mother liquor, the volume of the mother liquor bottle 15 is first determined, and the amount of diluent to be injected is confirmed, including the volume of the pipeline. The total dilution amount is then input into the system, and the system will automatically dilute the mother liquor and vent the pipeline.

[0036] It should be noted that the interface for dispensing radioactive mother liquor is as follows: Figure 7 As shown.

[0037] Specifically, the control module performs dilution, switching the clamp valve 07, closing the mother liquor branch 09, opening the dilution branch 08, and starting the first peristaltic pump 10. The diluent flows through the pipeline to the air sensor 06, triggering a signal that the system begins flow statistics, and the diluent continues to flow into the syringe 04. Once the required volume of diluent is reached, the first peristaltic pump 10 stops. The diluent in the syringe 04 contains the gas from the pipeline.

[0038] S602, The control module delivers the set volume of diluent in the syringe 04 to the mother liquor bottle 15 to dilute the mother liquor in the mother liquor bottle 15.

[0039] Specifically, the control module controls the switching of the clamp valve 07, closes the dilution branch 08, opens the mother liquor branch 09, and starts the second peristaltic pump 11 to transfer the diluent and gas in the syringe 04 to the mother liquor bottle 15. The gas in the mother liquor branch 09 is discharged by the exhaust needle 16, and the diluent in the syringe 04 is transferred to the mother liquor bottle 15 for mother liquor dilution.

[0040] S603, the control module moves the syringe 04 into the activity meter 03 through the lifting mechanism.

[0041] Specifically, the control module can perform high-precision syringe 04 dispensing, acquire patient information, calculate the required activity level for the patient, and, after confirmation, perform high-precision dispensing based on the activity level. The interface for dispensing radioactive mother liquor, which includes patient information, is shown below. Figure 8 As shown.

[0042] Specifically, the control module can control the lifting device 01 to descend, and use the basket 05 to lower the syringe 04 into the activity meter 03 well.

[0043] S604 The control module continuously delivers the diluted mother liquor in the mother liquor bottle 15 to the syringe 04, and monitors the activity of the mother liquor in the syringe 04 through the activity meter 03 until the activity of the mother liquor in the syringe 04 reaches the set activity range.

[0044] Optionally, step S604 includes: The control module cuts off the dilution pipeline and opens the mother liquor branch 09 through the clamp valve 07, draws a first diluted mother liquor with a volume of V1 from the mother liquor bottle 15, and delivers the first diluted mother liquor into the syringe 04 through the mother liquor branch 09 and the inlet / outlet line 17; where V1 is the product of the dead volume of the mother liquor branch 09 and N1, and N1 is a coefficient greater than 1. The control module cuts off the mother liquor branch 09 and opens the dilution pipeline through the clamp valve 07, draws a first diluent with a volume of V2 from the dilution bottle 12, and delivers the first diluent into the syringe 04 through the dilution branch 08 and the inlet / outlet line 17; where V2 is the product of the dead volume of the inlet / outlet line 17 and N2, and N2 is a coefficient greater than 1. The control module determines that the activity of the mother liquor in the syringe 04 has increased based on the activity meter 03, and determines that all the diluted mother liquor in the inlet / outlet line 17 has been pushed into the syringe 04. Then, based on the bisection method, the diluted mother liquor in the mother liquor bottle 15 is continuously delivered into the syringe 04, and the activity of the mother liquor in the syringe 04 is monitored by the activity meter 03 until the activity of the mother liquor in the syringe 04 reaches the set activity range.

[0045] Specifically, the control module switches the clamp valve 07, cutting off the dilution branch 08 and opening the mother liquor branch 09. The second peristaltic pump 11 starts to draw the diluted mother liquor from the mother liquor bottle 15 into the syringe 04. The activity meter 03 measures the activity in the syringe 04 in real time, and the system starts to count the volume while detecting the activity change. When the required activity is reached, the amount of volume transferred into the syringe 04 is also recorded. The second peristaltic pump 11 stops working, the clamp valve 07 switches, closing the mother liquor branch 09 and opening the dilution branch 08. The system calculates the remaining volume of diluent to be injected into the syringe 04 based on the remaining capacity of the syringe 04, and completes further dilution. The first peristaltic pump 10 starts to draw the diluent into the syringe 04, and stops after the required amount is reached.

[0046] Specifically, in order to ensure that the dispensing activity meets the accuracy requirements, this embodiment can use the dichotomy method to dispense the mother liquor, so that the activity of the mother liquor in syringe 04 reaches the set activity range.

[0047] Optionally, the above-mentioned method of continuously delivering the diluted mother liquor from the mother liquor bottle 15 to the syringe 04 based on the dichotomy method, and monitoring the activity of the mother liquor in the syringe 04 using an activity meter 03 until the activity of the mother liquor in the syringe 04 reaches a set activity range, includes: The control module divides the required activity value of the mother liquor in syringe 04 by the volume activity of the diluted mother liquor in mother liquor bottle 15, and obtains the corresponding product as the current dispensing volume. The control module calculates the target product of the current dispensing volume and the preset dilution coefficient, cuts off the dilution pipeline and opens the mother liquor branch 09 through the clamp valve 07, extracts the second diluted mother liquor with a volume equal to the target product from the mother liquor bottle 15, and delivers the second diluted mother liquor into the syringe 04 through the mother liquor branch 09 and the inlet / outlet pipeline 17. The control module cuts off the mother liquor branch 09 and opens the dilution line through the clamp valve 07, draws a second diluent with a volume of V2 from the dilution bottle 12, and delivers the second diluent into the syringe 04 through the dilution branch 08 and the inlet / outlet line 17. The control module monitors the positional relationship between the current mother liquor activity and the set activity range in syringe 04 based on the activity meter 03. If the current mother liquor activity has not reached the set activity range, the control module calculates the difference between the required mother liquor activity value and the current mother liquor activity value, divides the difference by the volume activity to obtain the new dispensing volume and uses it as the current dispensing volume, and returns to execute the step of calculating the target product of the current dispensing volume and the preset dichotomy coefficient until it is determined that the current mother liquor activity has reached the set activity range.

[0048] Optionally, the above system also includes: The tungsten sleeve 02 is installed on the lifting device 01 and is located at the second set position on the lifting path of the syringe 04. The first set position is higher than the second set position. It is used to house the pre-packaged syringe 04. At this point, after determining that the current mother liquor activity has reached the set activity range, the above method further includes: The control module lifts the syringe 04 out of the well of the activity meter 03 via the lifting mechanism and fits it inside the tungsten sleeve 02; At this point, after the above method monitors the positional relationship between the current mother liquor activity and the set activity range in syringe 04 based on the activity meter 03, it further includes: If the current activity of the mother liquor in syringe 04 exceeds the set activity range, the control module determines that there is a dispensing error and outputs an alarm message.

[0049] To better illustrate the binary sorting process, this embodiment provides the following Example 1: Step 1: The initial state has been completed by emptying the pipeline, meaning that the pipeline is filled with diluent; Step 2, parameter initialization: given the volume activity a of the mother liquor, the system automatically converts it into the required volume of mother liquor v=x / a according to the required activity value x; the subpackaging coefficient s is set, and generally s=0.5; Step 3, the pinch valve 07 switches to open the mother liquor branch 09 and close the dilution branch 08; Step 4, the second peristaltic pump 11 is started to extract a certain volume of mother liquor, which is generally 1.2 times the dead volume of the mother liquor branch 09, so as to ensure that all the diluent in the mother liquor branch 09 is replaced with mother liquor; Step 5, the second peristaltic pump 11 stops working, the pinch valve 07 switches to close the mother liquor branch 09 and open the dilution branch 08; Step 6, the first peristaltic pump 10 is started to extract a certain volume of diluent, which is generally 1.5 times the dead volume of the inlet and outlet pipeline 17, so as to ensure that all the mother liquor in the inlet and outlet pipeline 17 is pushed into the syringe 04; Step 7, the first peristaltic pump 10 stops working; Step 8, judgment: if the real-time value C of the activity meter 03 shows that mother liquor is injected into the syringe 04, it indicates that all the diluent in the mother liquor branch 09 has been replaced with mother liquor, and all the mother liquor in the inlet and outlet pipeline 17 has been pushed into the syringe 04, then proceed to the next step; if the value of the activity meter 03 does not change, return to Step 3; Step 9, the pinch valve 07 switches to open the mother liquor branch 09 and close the dilution branch 08; Step 10, the second peristaltic pump 11 is started to extract v×s of mother liquor. At this time, all the diluent in the mother liquor branch 09 has been replaced with mother liquor, so the newly extracted mother liquor is all pushed into the inlet and outlet pipeline 17; Step 11, the second peristaltic pump 11 stops working, the pinch valve 07 switches to close the mother liquor branch 09 and open the dilution branch 08; Step 12, the first peristaltic pump 10 is started to extract a certain volume of diluent, which is generally 1.5 times the dead volume of the inlet and outlet pipeline 17, so as to ensure that all the mother liquor in the inlet and outlet pipeline 17 is pushed into the syringe 04; Step 13, the first peristaltic pump 10 stops working; Step 14, judgment: if the real-time value C of the activity meter 03 satisfies C<x-x×3%, where 3% is the subpackaging accuracy of the equipment, it indicates that the mother liquor subpackaging has not reached the specified activity, the subpackaging volume of mother liquor is updated to v=(x-C) / a, and the program returns to Step 9; if the real-time value C of the activity meter 03 satisfies x-x×3%<C<x+x×3%, the program proceeds to the next step; if the real-time value C of the activity meter 03 satisfies C>x+x×3%, the program is interrupted and an alarm is triggered; Step 15, the subpackaging of the mother liquor according to the required activity is completed; Step 16: The lifting device 01 rises, and the syringe 04 is lifted out of the activity meter 03 well together with the basket 05. The tungsten sleeve 02 is then fitted on, completing the high-progress syringe 04 disassembly.

[0050] The radioactive mother liquor dispensing method proposed in this embodiment involves a control module delivering a set volume of diluent to a syringe 04 from a dilution bottle 12. This set volume of diluent is then transferred from the syringe 04 to a mother liquor bottle 15, diluting the mother liquor in the bottle. A lifting mechanism moves the syringe 04 to an activity meter 03, continuously delivering the diluted mother liquor from the bottle 15 to the syringe 04. The activity of the mother liquor in the syringe 04 is monitored by the activity meter 03 until it reaches a set activity range. This embodiment automates the mother liquor dilution and dispensing process, reducing manual operations performed by personnel in a radioactive environment and avoiding the risk of radiation damage. It also achieves high-precision mother liquor dispensing, with the dispensed syringe 04 then inserted into a tungsten sleeve 02, demonstrating a high degree of automation and integration.

[0051] like Figure 9 As shown, this embodiment proposes a control module applicable to any of the above-mentioned compact radioactive mother liquor dispensing systems. This control module may include: The delivery unit 901 is used to deliver a set volume of diluent into the syringe 04 based on the dilution bottle 12; The dilution unit 902 is used to deliver a set volume of diluent from the syringe 04 to the mother liquor bottle 15 to dilute the mother liquor in the mother liquor bottle 15. The moving unit 903 is used to move the syringe 04 into the activity meter 03 via a lifting mechanism; The dispensing unit 904 is used to continuously deliver the diluted mother liquor in the mother liquor bottle 15 to the syringe 04, and monitor the activity of the mother liquor in the syringe 04 through the activity meter 03 until the activity of the mother liquor in the syringe 04 reaches the set activity range.

[0052] It should be noted that the processing procedures and beneficial effects of the conveying unit 901, dilution unit 902, moving unit 903, and dispensing unit 904 can be referred to respectively. Figure 1 Steps S601 to S604 in the process will not be described again.

[0053] Optionally, the aforementioned packaging unit 604 is also used for: By cutting off the dilution pipeline and opening the mother liquor branch 09 through the clamp valve 07, a first diluted mother liquor with a volume of V1 is drawn from the mother liquor bottle 15 and delivered to the syringe 04 through the mother liquor branch 09 and the inlet / outlet line 17; where V1 is the product of the dead volume of the mother liquor branch 09 and N1, and N1 is a coefficient greater than 1. By cutting off the mother liquor branch 09 and opening the dilution line through the clamp valve 07, a first diluent with a volume of V2 is drawn from the dilution bottle 12 and delivered to the syringe 04 through the dilution branch 08 and the inlet / outlet line 17; where V2 is the product of the dead volume of the inlet / outlet line 17 and N2, and N2 is a coefficient greater than 1. Based on the activity meter 03 determining that the activity of the mother liquor in the syringe 04 has increased, and determining that all the diluted mother liquor in the inlet / outlet line 17 has been pushed into the syringe 04, the diluted mother liquor in the mother liquor bottle 15 is continuously delivered into the syringe 04 based on the dichotomy method, and the activity of the mother liquor in the syringe 04 is monitored by the activity meter 03 until the activity of the mother liquor in the syringe 04 reaches the set activity range.

[0054] Optionally, the packaging unit 604 is also used for: Divide the required activity value of the mother liquor in syringe 04 by the volumetric activity of the diluted mother liquor in mother liquor bottle 15 to obtain the corresponding product and use it as the current dispensing volume. Calculate the target product of the current dispensing volume and the preset dilution coefficient, cut off the dilution pipeline and open the mother liquor branch 09 through the clamp valve 07, extract the second diluted mother liquor with a volume equal to the target product from the mother liquor bottle 15, and deliver the second diluted mother liquor into the syringe 04 through the mother liquor branch 09 and the inlet / outlet pipeline 17. By cutting off the mother liquor branch 09 and opening the dilution line through the clamp valve 07, a second diluent with a volume of V2 is drawn from the dilution bottle 12 and delivered to the syringe 04 through the dilution branch 08 and the inlet / outlet line 17. Based on the positional relationship between the current mother liquor activity and the set activity range monitored by activity meter 03 in syringe 04; If the current mother liquor activity has not reached the set activity range, the control module calculates the difference between the required mother liquor activity value and the current mother liquor activity value, divides the difference by the volume activity to obtain the new dispensing volume and uses it as the current dispensing volume, and returns to execute the step of calculating the target product of the current dispensing volume and the preset dichotomy coefficient until it is determined that the current mother liquor activity has reached the set activity range.

[0055] Optionally, the above system also includes: The tungsten sleeve 02 is installed on the lifting device 01 and is located at the second set position on the lifting path of the syringe 04. The first set position is higher than the second set position. It is used to house the pre-packaged syringe 04. The aforementioned control module also includes: The kit unit is used to lift the syringe 04 out of the well of the activity meter 03 via a lifting mechanism after determining that the current mother liquor activity has reached the set activity range, and then fit it into the tungsten sleeve 02. The aforementioned control module also includes: The alarm unit is used to determine that a dispensing error has occurred if the current mother liquor activity in the syringe 04 exceeds the set activity range after the activity meter 03 monitors the positional relationship between the current mother liquor activity and the set activity range. The control module then outputs an alarm message.

[0056] The control module proposed in this embodiment can control the operating status of the dilution branch 08 and the mother liquor branch 09 through the clamp valve 07. It uses the diluent in the dilution bottle 12 to dilute the mother liquor in the mother liquor bottle 15, and delivers the diluted mother liquor in the mother liquor bottle 15 and the diluent in the dilution bottle 12 to the syringe 04 for mother liquor dispensing. This realizes the automated operation of mother liquor dilution and dispensing, reduces the manual operation of the staff for mother liquor dilution and dispensing in the radioactive environment, avoids the risk of radiation damage, and can also realize high-precision mother liquor dispensing. After dispensing, the syringe 04 is loaded into the tungsten sleeve 02, with a high degree of automation integration.

[0057] In this embodiment, the control module is presented in the form of a functional unit. Here, a unit refers to an ASIC (Application Specific Integrated Circuit) circuit, a processor and memory that execute one or more software or fixed programs, and / or other devices that can provide the above functions.

[0058] This invention also provides a computer device having the above-described features. Figure 3 The control module shown.

[0059] Please see Figure 10 The present invention provides a schematic diagram of the structure of a computer device according to an optional embodiment. The computer device includes one or more processors 101, a memory 102, and interfaces for connecting the various components, including high-speed interfaces and low-speed interfaces. The various components are interconnected via different buses and can be mounted on a common motherboard or otherwise installed as needed. The processors can process instructions executed within the computer device, including instructions stored in or on memory to display graphical information of a GUI on an external input / output device (such as a display device coupled to the interface). In some optional embodiments, multiple processors and / or multiple buses can be used with multiple memories, if desired. Similarly, multiple computer devices can be connected, each providing some of the necessary operations (e.g., as a server array, a group of blade servers, or a multiprocessor device). Figure 4 Take a processor 101 as an example.

[0060] Processor 101 may be a central processing unit, a network processor, or a combination thereof. Processor 101 may further include a hardware chip. The hardware chip may be an application-specific integrated circuit (ASIC), a programmable logic device (PLD), or a combination thereof. The programmable logic device may be a complex programmable logic device (CAMP), a field-programmable gate array (FPGA), a general-purpose array logic (GDA), or any combination thereof.

[0061] The memory 102 stores instructions executable by at least one processor 101 to cause at least one processor 101 to perform the method shown in the above embodiments.

[0062] Memory 102 may include a program storage area and a data storage area, wherein the program storage area may store application programs required for operating the device and at least one function. The data storage area may store data created based on the use of the computer device. Furthermore, memory 102 may include high-speed random access memory and may also include non-transitory memory, such as at least one disk storage device, flash memory device, or other non-transitory solid-state storage device. In some alternative embodiments, memory 102 may optionally include memory remotely located relative to processor 101, and this remote memory may be connected to the computer device via a network. Examples of such networks include, but are not limited to, the Internet, intranets, local area networks, mobile communication networks, and combinations thereof.

[0063] Memory 102 may include volatile memory, such as random access memory. Memory may also include non-volatile memory, such as flash memory, hard disk, or solid-state drive. Memory 102 may also include combinations of the above types of memory.

[0064] The computer device also includes a communication interface 103 for communicating with other devices or communication networks.

[0065] This invention also provides a computer-readable storage medium. The methods described above according to embodiments of the invention can be implemented in hardware or firmware, or implemented as computer code that can be recorded on a storage medium, or implemented as computer code downloaded via a network and originally stored on a remote storage medium or a non-transitory machine-readable storage medium and then stored on a local storage medium. Thus, the methods described herein can be processed by software stored on a storage medium using a general-purpose computer, a dedicated processor, or programmable or dedicated hardware. The storage medium can be a magnetic disk, optical disk, read-only memory, random access memory, flash memory, hard disk, or solid-state drive, etc.; further, the storage medium can also include combinations of the above types of memory. It is understood that computers, processors, microprocessor controllers, or programmable hardware include storage components capable of storing or receiving software or computer code, which, when accessed and executed by the computer, processor, or hardware, implements the methods shown in the above embodiments.

[0066] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A compact radioactive mother liquor dispensing system, characterized in that, include: Lifting mechanism; The syringe is vertically suspended on the lifting mechanism, with its inlet and outlet facing upwards; An activity meter is installed at a first predetermined position on the syringe lifting path to monitor the activity of the mother liquor in the syringe. Inlet and outlet lines, one end of which is connected to the common inlet and outlet end of the syringe; Mother liquor bottle and dilution bottle, the bottles contain mother liquor and diluent respectively; The system includes a mother liquor branch and a dilution branch. One end of the mother liquor branch is connected to the common inlet and outlet of the mother liquor bottle, and one end of the dilution branch is connected to the outlet of the dilution bottle. The other end of the dilution branch and the other end of the mother liquor branch are common ends, and the common ends are connected to the other ends of the inlet and outlet pipelines. A pinch valve is installed on the dilution branch and the mother liquor branch to switch the open and closed states of the dilution branch and the mother liquor branch; An air sensor is installed on the inlet and outlet pipelines; The control module is communicatively connected to the lifting mechanism, the dilution branch, the mother liquor branch, the clamp valve, and the air sensor. It is used to dilute the mother liquor in the mother liquor bottle through the dilution branch and the mother liquor branch, and to dispense the diluted mother liquor into the syringe.

2. The system according to claim 1, characterized in that, The dilution branch includes: The first peristaltic pump has its input pipe connected to the output end of the dilution bottle, and the output end is the common end of the dilution branch and the mother liquor branch.

3. The system according to claim 2, characterized in that, The mother liquor branch includes: A spacer sleeve is fitted onto the outer wall of the mother liquor bottle; The shielding groove contains both the mother liquor bottle and the spacer. The venting needle has its tip inserted into the mother liquor bottle through the bottle cap and is in the gas inside the bottle, while the needle seat is located outside the mother liquor bottle. A liquid extraction needle, the tip of which is inserted into the mother liquor bottle through the cap and into the liquid inside the bottle; The second peristaltic pump has an input pipe connected to the needle seat of the aspiration needle, and an output end that is the common end of the dilution branch and the mother liquor branch.

4. The system according to claim 3, characterized in that, The clamp valve is located at the first control end of the dilution branch on the pipeline between the common end and the first peristaltic pump. The clamp valve is located at the second control end of the mother liquor branch, on the pipeline between the common end and the second peristaltic pump.

5. The system according to claim 1, characterized in that, The lifting mechanism includes: Elevator; The suspended platform is installed on the lifting device; The syringe is vertically suspended on the basket, with the liquid inlet and outlet of the syringe facing upwards.

6. The system according to claim 5, characterized in that, The system also includes: A tungsten sleeve is installed on the lifting device and located at a second predetermined position on the lifting path of the syringe. The first predetermined position is higher than the second predetermined position. It is used to house the pre-packaged syringe.

7. A method for dispensing radioactive mother liquor, characterized in that, A compact radioactive mother liquor dispensing system according to any one of claims 1 to 6, the system comprising a lifting mechanism, a syringe, an activity meter, inlet and outlet pipelines, a mother liquor bottle, a dilution bottle, a mother liquor branch, a dilution branch, a clamp valve, an air sensor, and a control module; The method includes: The control module delivers a set volume of diluent into the syringe based on the dilution bottle; The control module delivers the set volume of diluent from the syringe to the mother liquor bottle to dilute the mother liquor in the mother liquor bottle; The control module moves the syringe into the activity meter via the lifting mechanism; The control module continuously delivers the diluted mother liquor from the mother liquor bottle to the syringe and monitors the activity of the mother liquor in the syringe using the activity meter until the activity of the mother liquor in the syringe reaches the set activity range.

8. The method according to claim 7, characterized in that, The control module continuously delivers the diluted mother liquor from the mother liquor bottle to the syringe, and monitors the activity of the mother liquor in the syringe using the activity meter until the activity of the mother liquor in the syringe reaches a set activity range, including: The control module cuts off the dilution pipeline and opens the mother liquor branch through the clamp valve, extracts a first diluted mother liquor with a volume of V1 from the mother liquor bottle, and delivers the first diluted mother liquor into the syringe through the mother liquor branch and the inlet / outlet pipeline; wherein, V1 is the product of the dead volume of the mother liquor branch pipeline and N1, and N1 is a coefficient greater than 1; The control module cuts off the mother liquor branch and opens the dilution pipeline through the clamp valve, draws a first diluent with a volume of V2 from the dilution bottle, and delivers the first diluent into the syringe through the dilution branch and the inlet and outlet lines; wherein, V2 is the product of the dead volume of the inlet and outlet lines and N2, and N2 is a coefficient greater than 1; The control module determines, based on the activity meter, that the activity of the mother liquor in the syringe has increased, and that all the diluted mother liquor in the inlet and outlet lines has been pushed into the syringe. Then, based on the dichotomy method, it continuously delivers the diluted mother liquor in the mother liquor bottle into the syringe, and monitors the activity of the mother liquor in the syringe through the activity meter until the activity of the mother liquor in the syringe reaches the set activity range.

9. The method according to claim 8, characterized in that, The method of continuously delivering diluted mother liquor from the mother liquor bottle to the syringe based on the dichotomy method, and monitoring the activity of the mother liquor in the syringe using the activity meter until the activity of the mother liquor in the syringe reaches a set activity range, includes: The control module divides the required activity value of the mother liquor in the syringe by the volume activity of the diluted mother liquor in the mother liquor bottle to obtain the corresponding product and uses it as the current dispensing volume. The control module calculates the target product of the current dispensing volume and the preset dilution coefficient, cuts off the dilution pipeline and opens the mother liquor branch through the clamp valve, extracts a second diluted mother liquor with a volume equal to the target product from the mother liquor bottle, and delivers the second diluted mother liquor into the syringe through the mother liquor branch and the inlet / outlet pipeline; The control module cuts off the mother liquor branch and opens the dilution pipeline through the clamp valve, draws a second diluent with a volume of V2 from the dilution bottle, and delivers the second diluent into the syringe through the dilution branch and the inlet / outlet pipeline. The control module monitors the positional relationship between the current mother liquor activity in the syringe and the set activity range based on the activity meter. If the current mother liquor activity has not reached the set activity range, the control module calculates the difference between the required mother liquor activity value and the current mother liquor activity, divides the difference by the volumetric activity to obtain a new dispensing volume and uses it as the current dispensing volume, and returns to execute the step of calculating the target product of the current dispensing volume and the preset bisection coefficient until it is determined that the current mother liquor activity has reached the set activity range.

10. The method according to claim 9, characterized in that, The system also includes: A tungsten sleeve is installed on the lifting device and located at a second predetermined position on the lifting path of the syringe. The first predetermined position is higher than the second predetermined position. It is used to house the pre-packaged syringe. After determining that the current mother liquor activity has reached the set activity range, the method further includes: The control module lifts the syringe out of the well of the activity meter via the lifting mechanism and fits it inside the tungsten sleeve; After monitoring the positional relationship between the current mother liquor activity in the syringe and the set activity range based on the activity meter, the method further includes: If the current activity of the mother liquor in the syringe exceeds the set activity range, the control module determines that a dispensing error has occurred and outputs an alarm message.

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