Floating catheter applied to research on pulmonary arterial hypertension of small animals

Abstract

The utility model discloses a floating catheter applied to small animal pulmonary arterial hypertension research, and relates to the technical field of floating catheters for rat pulmonary arterial hypertension research, the floating catheter comprises a catheter main body, one end of the catheter main body is an installation end, the other end of the catheter main body is a puncture end, and the puncture end is provided with a balloon. A balloon inflation tube, a far-end extension tube and a thermosensitive guide wire are arranged at the mounting end, a balloon inflation tube cavity, a thermosensitive guide wire imbedding tube cavity and a pressure sensor line imbedding tube cavity which are mutually separated and independent are formed in the catheter body in the axial direction, and a tube cavity branch tube connector is arranged at the end, close to the mounting end, of the catheter body. According to the utility model, the floating catheter is made of the flexible material so as to adapt to the blood vessel form of the rat, and the catheter has the characteristics of miniaturization, simplicity and convenience in operation, comprehensive functions and the like, and can effectively monitor the pulmonary artery pressure of the rat; the method has a wide application prospect in the fundamental research of pulmonary arterial hypertension.

Description

Technical Field

[0001] The utility model relates to the technical field of floating catheters for research on rat pulmonary hypertension, in particular to a floating catheter used for research on small animal pulmonary hypertension. Background Art

[0002] Pulmonary arterial hypertension (PAH) is a serious cardiovascular disease, known as the "cancer" in the cardiovascular field, and has attracted much attention due to its high morbidity, high disability rate and high mortality rate. One of the commonly used means for clinical diagnosis and treatment of PAH is right heart floating catheter, especially in the diagnosis of pulmonary hypertension, it is regarded as the gold standard, however, the application of floating catheter is mainly limited to large animal experiments and human clinical studies, which is mainly due to its complexity and high cost.

[0003] Although pulmonary hypertension research conducted in large animals such as pigs and dogs can provide valuable experimental data, the physiological differences between these animals and humans may lead to limitations in experimental results. In addition, large animal experiments are expensive, which limits the scale and speed of research. In contrast, small animals such as rats have many advantages in biomedical research, such as low cost, rapid reproduction, and convenient gene editing. However, due to the lack of floating catheters suitable for small animals, current research on pulmonary hypertension in small animal models is relatively limited. Therefore, there is an urgent clinical and research need to develop a floating catheter suitable for small animals (such as rats). Utility Model Content

[0004] The utility model aims to solve the shortcomings of the prior art and proposes a floating catheter used for research on pulmonary hypertension in small animals.

[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0006] A floating catheter used for the study of pulmonary hypertension in small animals, comprising a catheter body, one end of the catheter body being a mounting end, and the other end being a puncture end, the puncture end being provided with a balloon, the mounting end being provided with a balloon inflation tube, a distal extension tube and a thermal guide wire, the catheter body being provided with a balloon inflation lumen, a thermal guide wire insertion lumen and a pressure sensor line insertion lumen which are independently spaced from each other along the axial direction, the end of the catheter body close to the mounting end being provided with a lumen branch joint, and the port of the thermal guide wire insertion lumen being provided with a thermistor;

[0007] The balloon inflation tube, the distal extension tube and the thermosensitive guide wire are respectively connected to the balloon inflation lumen, the thermosensitive guide wire insertion lumen and the pressure sensor line insertion lumen through the lumen branch pipe joint;

[0008] The balloon inflation tube is connected to the inflation syringe, and the balloon does not cover the distal end port of the puncture end after being inflated.

[0009] The above technical solution further includes: the catheter body is a flexible pipe made of polyethylene material.

[0010] Furthermore, the outer diameter of the catheter body is 1.8 mm.

[0011] Furthermore, the diameter of the balloon after inflation is 0.6 to 2.2 mm.

[0012] Furthermore, a valve is installed on the balloon inflation tube.

[0013] Furthermore, a pressure sensor is installed at the port position of the distal port, and the pressure sensor is electrically connected to the controller via a Luer connector, and the controller is electrically connected to a display screen.

[0014] Furthermore, the thermistor is electrically connected to the thermistor wire, and the thermistor wire is electrically connected to the controller.

[0015] Furthermore, a spiral groove is provided on the outer wall of the front end of the puncture end.

[0016] Furthermore, a puncture outer sheath is installed at the front end of the balloon.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] In the utility model, the floating catheter is made of flexible material to adapt to the vascular morphology of rats. The catheter has the characteristics of miniaturization, easy operation, and comprehensive functions. It can effectively monitor the pulmonary artery pressure of rats and has broad application prospects in basic research on pulmonary hypertension. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The utility model is a schematic diagram of the overall structure of a floating catheter used for studying pulmonary hypertension in small animals.

[0020] In the figure:

[0021] 1. Catheter body; 11. Mounting end; 12. Puncture end; 13. Spiral groove; 21. Balloon; 22. Balloon inflation tube; 23. Valve; 24. Inflation syringe; 3. Lumen branch connector; 41. Distal extension tube; 42. Luer connector; 43. Distal port; 51. Thermistor; 52. Thermistor; 6. Puncture outer sheath. DETAILED DESCRIPTION

[0022] The technical solution of the utility model is further described below in conjunction with the accompanying drawings and specific embodiments.

[0023] Embodiment 1

[0024] Refer to the attached Figure 1 The utility model proposes a floating catheter for the study of pulmonary hypertension in small animals, comprising a catheter body 1, one end of the catheter body 1 is a mounting end 11, and the other end is a puncture end 12, the puncture end 12 is provided with a balloon 21, the mounting end 11 is provided with a balloon inflation tube 22, a distal extension tube 41 and a thermal guide wire 51, and the catheter body 1 is provided with a balloon inflation lumen, a thermal guide wire insertion lumen and a pressure sensor line insertion lumen that are independently spaced from each other along the axial direction, and the end of the catheter body 1 close to the mounting end 11 is provided with a lumen branch pipe joint 3, and a thermistor 52 is installed at the port of the thermal guide wire insertion lumen;

[0025] The balloon inflation tube 22, the distal extension tube 41 and the thermal guide wire 51 are respectively connected to the balloon inflation lumen, the thermal guide wire insertion lumen and the pressure sensor line insertion lumen through the lumen branch pipe joint 3;

[0026] The balloon inflation tube 22 is connected to the inflation syringe 24 . After the balloon 21 is inflated, the distal end port 43 of the puncture end 12 is not covered, and the thermistor 52 is not covered.

[0027] The catheter body 1 is a flexible tube made of polyethylene material; wherein, the flexible tube made of polyethylene material has good compatibility with rat vascular tissue and will not cause obvious immune response or inflammation. The flexible tube made of polyethylene material has a certain flexibility and can adapt to the bending and twisting of the rat vascular system, reducing damage to the vascular wall.

[0028] The outer diameter of the catheter body 1 is 1.8 mm.

[0029] The diameter of the balloon 21 after inflation is 0.6-2.2 mm.

[0030] A valve 23 is installed on the balloon inflation tube 22; wherein, a scale is provided on the inflation syringe 24 to facilitate operation and control of the balloon size.

[0031] A puncture outer sheath tube 6 is installed at the front end of the balloon 21; the puncture outer sheath tube 6 is provided to facilitate the transportation of the floating catheter.

[0032] A pressure sensor is installed at the port position of the distal port 43, and the pressure sensor is electrically connected to the controller through the Luer connector 42, and the controller is electrically connected to the display screen; wherein the Luer connector 42, as a standardized micro-seepage-free connector, ensures a stable, leak-free connection between the pressure sensor and the floating catheter, and this connection allows the pressure sensor to accurately measure the pressure changes in the pulmonary artery and convert these pressure signals into electrical signals. The controller performs corresponding operations based on the received pressure data, such as displaying on the display screen, recording data or triggering an alarm, etc. In this way, the close connection between the controller, the pressure sensor and the Luer connector enables the entire system to achieve accurate monitoring and control of pressure changes in the pulmonary artery.

[0033] The thermistor 52 is electrically connected to the thermistor wire 51, and the thermistor wire 51 is electrically connected to the controller; when the temperature changes, the resistance value of the thermistor 52 will change, thereby generating a corresponding electrical signal, and the thermistor wire 51 serves as a transmission medium for the electrical signal, transmitting the electrical signal generated by the thermistor 52 to the controller. After receiving the electrical signal from the thermistor wire 51, the controller will perform necessary processing and analysis. Therefore, the thermistor realizes the transmission and further processing of temperature information through the electrical connection between the thermistor wire and the controller, thereby providing real-time monitoring and data analysis of the rat's body temperature.

[0034] A spiral groove 13 is provided on the outer wall of the front end of the puncture end 12; wherein, the design of the spiral groove 13 can increase the lateral stability of the catheter body 1 in the pulmonary artery. When the balloon 21 is inflated and expanded, the spiral groove 13 can form a certain friction force with the pulmonary artery wall, reducing the drift or movement of the catheter in the blood flow, thereby ensuring that the catheter can be stably maintained in a predetermined position.

[0035] In this embodiment, the floating catheter is designed to adapt to the vascular morphology of rats. The catheter has the characteristics of miniaturization, easy operation, and comprehensive functions. It can effectively monitor the pulmonary artery pressure of rats and has broad application prospects in basic research on pulmonary hypertension.

[0036] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A floating catheter for use in the study of pulmonary hypertension in small animals, characterized in that: The catheter body (1) comprises a catheter body, one end of which is a mounting end (11) and the other end is a puncture end (12), the puncture end (12) being provided with a balloon (21), the mounting end (11) being provided with a balloon inflation tube (22), a distal extension tube (41) and a thermal guide wire (51), the catheter body (1) being provided with a balloon inflation lumen, a thermal guide wire insertion lumen and a pressure sensor line insertion lumen which are independently spaced from each other along the axial direction, the end of the catheter body (1) close to the mounting end (11) being provided with a lumen branch joint (3), and the port of the thermal guide wire insertion lumen being provided with a thermistor (52); The balloon inflation tube (22), the distal extension tube (41) and the thermal guide wire (51) are respectively connected to the balloon inflation lumen, the thermal guide wire insertion lumen and the pressure sensor line insertion lumen through the lumen branch pipe joint (3); The balloon inflation tube (22) is connected to the inflation syringe (24), and the balloon (21) does not cover the distal end port (43) of the puncture end (12) after being inflated.

2. A floating catheter for use in the study of pulmonary hypertension in small animals according to claim 1, characterized in that: The catheter body (1) is a flexible pipe made of polyethylene material.

3. A floating catheter for use in the study of pulmonary hypertension in small animals according to claim 2, characterized in that: The outer diameter of the catheter body (1) is 1.8 mm.

4. A floating catheter for use in the study of pulmonary hypertension in small animals according to claim 1, characterized in that: The balloon (21) has a diameter of 0.6 to 2.2 mm after being inflated.

5. The floating catheter for use in the study of pulmonary hypertension in small animals according to claim 1, characterized in that: The balloon inflation tube (22) is provided with a valve (23).

6. A floating catheter for use in the study of pulmonary hypertension in small animals according to claim 1, characterized in that: A pressure sensor is installed at the port position of the distal port (43), and the pressure sensor is electrically connected to a controller via a Luer connector (42), and the controller is electrically connected to a display screen.

7. A floating catheter for use in the study of pulmonary hypertension in small animals according to claim 6, characterized in that: The thermistor (52) is electrically connected to the thermal conductive wire (51), and the thermal conductive wire (51) is electrically connected to a controller.

8. The floating catheter for use in the study of pulmonary hypertension in small animals according to claim 1, characterized in that: A spiral groove (13) is provided on the front end outer wall of the puncture end (12).

9. The floating catheter for use in the study of pulmonary hypertension in small animals according to claim 1, characterized in that: A puncture outer sheath (6) is installed at the front end of the balloon (21).

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