Chromatographic column fixing device

Abstract

The utility model provides a chromatographic column fixing device. According to the chromatographic column fixing device, a through hole is formed in a fixing plate; the fixed plate is vertically fixed on the inner wall surface of the side wall of the U-shaped mounting plate; the first fixed shaft is fixed on the fixed plate; the second fixed shaft is fixed on the fixed plate; the multiple first clamping plates are vertically and rotatably connected to the first fixing shaft, first semicircular notches are formed in the side edges of the multiple first clamping plates, and the diameters of the multiple first semicircular notches are different; the multiple second clamping plates are vertically and rotatably connected to the second fixing shaft, second semicircular notches are formed in the side edges of the multiple second clamping plates, the multiple second semicircular notches are different in diameter, and the first semicircular notches and the second semicircular notches of the first clamping plates and the second clamping plates which are different in diameter can be folded to form multiple clamping holes different in diameter; the utility model relates to a chromatographic column fixing device, which belongs to the technical field of experimental equipment and can be used for clamping and fixing chromatographic columns with different diameters and improving the chromatographic purification effect.

Description

Technical Field

[0001] The utility model relates to a chromatography column fixing device, belonging to the technical field of experimental equipment. Background Art

[0002] Column chromatography generally refers to the use of column chromatography to separate and purify target substances. As a commonly used purification method, column chromatography can be used to purify and separate natural products and has been widely used in the pharmaceutical, food, and chemical industries. Column chromatography, also known as chromatography or chromatographic methods, separates substances based on their different adsorption capacities on a stationary phase. Generally, highly polar substances are more easily adsorbed by the stationary phase, while less polar substances are less easily adsorbed. The column chromatography process is a process of adsorption, desorption, re-adsorption, and re-desorption. Chromatography columns come in many specifications, such as columns of different diameters and columns with different fillers. Different chromatography columns are used for different purification operations. When performing biological experiments, such as protein purification, the chromatography columns used are larger than the conventional ones, such as chromatography columns with a diameter of 50mm*200mm. During use, since the chromatography column is relatively large and the weight of the chromatography column filled with fillers and eluent will be heavier, it is particularly important to fix the chromatography column and ensure that the chromatography purification process can be completed normally.

[0003] The prior art CN219539490U discloses a chromatography column holder, in which the support rod is height-adjustable and the support plate can be fixed at any position on the support rod to fix chromatography columns of different lengths. The method of clamping the chromatography column by a clamping member has poor stability, and a stronger clamping force is required when the chromatography column is heavy, which can easily damage the chromatography column.

[0004] Therefore, there is an urgent need for a fixing frame that can maintain the vertical stability of a chromatography column and is suitable for chromatography columns of various sizes. Utility Model Content

[0005] The technical problem to be solved by the utility model is to provide a chromatography column fixing device, which can clamp and fix chromatography columns with different diameters, thereby improving the chromatography purification effect.

[0006] The utility model solves the above technical problems with the following technical solutions: A chromatography column fixing device comprising:

[0007] U-shaped mounting plate;

[0008] A fixing plate, wherein a through hole for the chromatography column to pass through is opened in the middle of the fixing plate; the fixing plate is vertically fixed to the inner wall surface of the side wall of the U-shaped mounting plate;

[0009] a first fixed shaft, the first fixed shaft being vertically fixed on the plate surface of the fixed plate;

[0010] a second fixed shaft, the second fixed shaft and the first fixed shaft being symmetrically arranged with respect to the through hole and vertically fixed on the plate surface of the fixed plate;

[0011] a plurality of first clamping plates, wherein the plate surfaces of the plurality of first clamping plates are vertically rotatably connected to the first fixed shaft, and the plurality of first clamping plates are each provided with a first semicircular notch on a side thereof, and the plurality of first semicircular notches have different diameters;

[0012] Multiple second clamping plates are arranged corresponding to the multiple first clamping plates and are vertically rotatably connected to the second fixed shaft. Second semicircular notches are opened on the sides of the multiple second clamping plates. The diameters of the multiple second semicircular notches are different. The first semicircular notches and the second semicircular notches of the first clamping plates and the second clamping plates of different diameters are matched to form multiple clamping holes with different diameters.

[0013] The beneficial effects of the present invention are as follows: the fixing plate is fixed on the inner wall of the U-shaped mounting plate, a plurality of first clamping plates and a plurality of second clamping plates are rotatably connected to the first fixed shaft and the second fixed shaft respectively, after the first clamping plate and the corresponding second clamping plate are aligned, the first semicircular notch and the second semicircular notch can form clamping holes of different diameters, and the chromatography column is clamped in the clamping hole. According to the diameter of the chromatography column, different first clamping plates and second clamping plates are selected, and chromatography columns of various diameters can be applied.

[0014] On the basis of the above technical solution, the present invention can also be improved as follows.

[0015] Furthermore, the first clamping plates are each provided with a first rotation hole, and the first rotation holes are rotationally connected to the first fixed shaft.

[0016] Furthermore, each of the plurality of second clamping plates is provided with a second rotation hole, and the plurality of second rotation holes are rotationally connected to the second fixed shaft.

[0017] Furthermore, a plurality of groups of the fixing plates, the first fixing shaft, the second fixing shaft, the first clamping plates and the second clamping plates are arranged in groups, and the fixing plates of each group are fixed to the inner side wall of the U-shaped mounting plate along the axial direction of the through hole.

[0018] The beneficial effect of adopting the above further solution is that multiple sets of fixing plates are fixed on the inner side wall of the U-shaped mounting plate along the axial direction of the through hole, which can fix the chromatography column at multiple positions to ensure that it is perpendicular to the bottom plate of the U-shaped mounting plate.

[0019] Furthermore, a plurality of groups of slots are symmetrically provided on the inner walls of both sides of the U-shaped mounting plate, and both sides of the fixing plate can be snapped into a group of the slots.

[0020] The beneficial effect of adopting the above further solution is that the installation of the fixing plate is facilitated.

[0021] Furthermore, each of the plurality of first clamping plates and the plurality of second clamping plates is fixed with a handle for facilitating rotation thereof.

[0022] The beneficial effect of adopting the above further solution is that the first clamping plate and the second clamping plate are easily rotated.

[0023] Furthermore, a storage gap is provided between the fixing plate of the lowest layer and the bottom plate of the U-shaped mounting plate.

[0024] Furthermore, elastic rubber pads are fixed to the side walls of the plurality of first semicircular notches and the plurality of second semicircular notches.

[0025] The beneficial effects of adopting the above further solution are: improving the clamping effect on the chromatography column and having a protective effect on the chromatography column. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a schematic structural diagram of a chromatography column fixing device provided by the present invention;

[0027] Figure 2 for Figure 1 Top view;

[0028] Figure 3 A side view of a fixing plate, a first fixing shaft, a second fixing shaft, a first clamping plate and a second clamping plate in a chromatography column fixing device provided by the present invention;

[0029] Figure 4 The present invention provides a structural schematic diagram of a chromatography column fixing device in a working state.

[0030] In the accompanying drawings, the components represented by the reference numerals are as follows:

[0031] 1-fixed plate, 2-first fixed axis, 3-second fixed axis, 4-first clamping plate, 5-second clamping plate, 6-through hole, 7-first semicircular notch, 8-second semicircular notch, 9-clamping hole, 10-U-shaped mounting plate, 11-handle, 12-storage gap. DETAILED DESCRIPTION

[0032] The principles and features of the present invention are described below in conjunction with the accompanying drawings. The examples given are only used to explain the present invention and are not used to limit the scope of the present invention.

[0033] The purpose of the utility model is to provide a chromatography column fixing device to solve the problems existing in the prior art, and to be able to clamp and fix chromatography columns of different diameters, thereby improving the chromatography purification effect.

[0034] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0035] The utility model provides a chromatography column fixing device, such as Figures 1 to 4 Shown, including:

[0036] U-shaped mounting plate 10;

[0037] A fixing plate 1, the middle portion of which is provided with a through hole 6 for the chromatography column to pass through; the fixing plate 1 is vertically fixed to the inner wall surface of the side wall of the U-shaped mounting plate 10;

[0038] A first fixed shaft 2, the first fixed shaft 2 is vertically fixed on the plate surface of the fixed plate 1;

[0039] a second fixed shaft 3, which is symmetrically arranged with the first fixed shaft 2 about the through hole 6 and is vertically fixed to the surface of the fixed plate 1;

[0040] A plurality of first clamping plates 4, wherein the plate surfaces of the plurality of first clamping plates 4 are vertically rotatably connected to the first fixed shaft 2, and the sides of the plurality of first clamping plates 4 are each provided with a first semicircular notch 7, and the diameters of the plurality of first semicircular notches 7 are different;

[0041] Multiple second clamping plates 5 are arranged corresponding to the multiple first clamping plates 4 and are vertically rotatably connected to the second fixed shaft 3. Second semicircular notches 8 are opened on the sides of the multiple second clamping plates 5. The diameters of the multiple second semicircular notches 8 are different. The first semicircular notches 7 and the second semicircular notches 8 of the first clamping plates 4 and the second clamping plates 5 of different diameters are matched to form multiple clamping holes 9 with different diameters.

[0042] The chromatography column fixing device provided by the present invention comprises a fixing plate 1 fixed on the inner wall of a U-shaped mounting plate 10, a plurality of first clamping plates 4 and a plurality of second clamping plates 5 rotatably connected to a first fixed shaft 2 and a second fixed shaft 3, respectively. After the first clamping plates 4 and the corresponding second clamping plates 5 are aligned, the first semicircular notches 7 and the second semicircular notches 8 can form clamping holes 9 of different diameters, and the chromatography column is clamped in the clamping holes 9. Different first clamping plates 4 and second clamping plates 5 are selected according to the diameter of the chromatography column, so that chromatography columns of various diameters can be applied.

[0043] In a specific embodiment of the present invention, the plurality of first clamping plates 4 are each provided with a first rotation hole, and the plurality of first rotation holes are rotatably connected to the first fixed shaft 2 .

[0044] In a specific embodiment of the present invention, the plurality of second clamping plates 5 are each provided with a second rotation hole, and the plurality of second rotation holes are rotatably connected to the second fixed shaft 3 .

[0045] In a specific embodiment of the present invention, multiple groups of fixed plates 1, first fixed shafts 2, second fixed shafts 3, first clamping plates 4 and second clamping plates 5 are arranged in groups, and the fixed plates 1 of each group are axially fixed on the inner wall of the U-shaped mounting plate 10 along the through hole 6.

[0046] Multiple sets of fixing plates 1 are fixed on the inner side wall of the U-shaped mounting plate 10 along the axial direction of the through hole 6, which can fix multiple positions of the chromatography column to ensure that it is perpendicular to the bottom plate of the U-shaped mounting plate 10, and can be fixed at different positions according to the actual height requirements of the chromatography column.

[0047] In a specific embodiment of the present invention, a plurality of first clamping plates 4 are rotatably connected to the first fixed shaft 2 at equal intervals along the axial direction of the first fixed shaft 2. According to the size of the chromatography column, a first clamping plate 4 having a first semicircular notch 7 of a suitable diameter is selected, and the corresponding second clamping plate 5 is aligned with the first clamping plate 4 to form a clamping hole.

[0048] In a specific embodiment of the present invention, multiple groups of slots are symmetrically formed on the inner walls of both sides of the U-shaped mounting plate 10 , and both sides of the fixing plate 1 can be snapped into one group of slots.

[0049] It is convenient to install the fixing plate 1.

[0050] In a specific embodiment of the present invention, a handle 11 is fixed to each of the plurality of first clamping plates 4 and the plurality of second clamping plates 5 to facilitate their rotation.

[0051] It is convenient to rotate the first clamping plate 4 and the second clamping plate 5.

[0052] In a specific embodiment of the present invention, a storage gap 12 is provided between the bottommost fixed plate 1 and the bottom plate of the U-shaped mounting plate 10. The storage gap 12 can accommodate the pipes and connection ports for connecting the chromatography column to the liquid flow, so that the chromatography liquid can flow out smoothly.

[0053] In a specific embodiment of the present invention, elastic rubber pads are fixed to the side walls of the plurality of first semicircular notches 7 and the plurality of second semicircular notches 8 .

[0054] The clamping effect on the chromatography column is improved and the chromatography column is protected.

[0055] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A chromatography column fixing device, It is characterized in that include: U-shaped mounting plate (10); A fixing plate (1), wherein a through hole (6) for the chromatography column to pass through is provided in the middle of the fixing plate (1); the fixing plate (1) is vertically fixed to the inner wall surface of the side wall of the U-shaped mounting plate (10); A first fixed shaft (2), the first fixed shaft (2) being vertically fixed on the plate surface of the fixed plate (1); a second fixed shaft (3), the second fixed shaft (3) and the first fixed shaft (2) being arranged symmetrically with respect to the through hole (6) and being vertically fixed on the plate surface of the fixed plate (1); A plurality of first clamping plates (4), the plate surfaces of the plurality of first clamping plates (4) being vertically rotatably connected to the first fixed shaft (2), the sides of the plurality of first clamping plates (4) being all provided with first semicircular notches (7), and the diameters of the plurality of first semicircular notches (7) being different; A plurality of second clamping plates (5) are arranged corresponding to the plurality of first clamping plates (4) and are vertically rotatably connected to the second fixed shaft (3); a second semicircular notch (8) is provided on the side of the plurality of second clamping plates (5); the diameters of the plurality of second semicircular notches (8) are different; the first semicircular notches (7) and the second semicircular notches (8) of the first clamping plates (4) and the second clamping plates (5) of different diameters can be matched to form a plurality of clamping holes (9) of different diameters.

2. A chromatography column fixing device according to claim 1, It is characterized in that A plurality of the first clamping plates (4) are each provided with a first rotation hole, and the plurality of the first rotation holes are rotationally connected to the first fixed shaft (2).

3. A chromatography column fixing device according to claim 1, It is characterized in that The plurality of second clamping plates (5) are each provided with a second rotation hole, and the plurality of second rotation holes are rotationally connected to the second fixed shaft (3).

4. A chromatography column fixing device according to claim 1, It is characterized in that The invention comprises a plurality of groups of the fixing plates (1), the first fixing shaft (2), the second fixing shaft (3), the first clamping plates (4) and the second clamping plates (5) arranged in groups, wherein the fixing plates (1) of each group are axially fixed on the inner side wall of the U-shaped mounting plate (10) along the through hole (6).

5. A chromatography column fixing device according to claim 4, It is characterized in that The inner walls of both sides of the U-shaped mounting plate (10) are symmetrically provided with a plurality of groups of slots, and both sides of the fixing plate (1) can be snapped into a group of the slots.

6. A chromatography column fixing device according to claim 5, It is characterized in that A handle (11) for facilitating rotation thereof is fixed on each of the plurality of first clamping plates (4) and the plurality of second clamping plates (5).

7. A chromatography column fixing device according to claim 6, It is characterized in that A storage gap (12) is provided between the fixing plate (1) at the bottom layer and the bottom plate of the U-shaped mounting plate (10).

8. A chromatography column fixing device according to claim 1, It is characterized in that Elastic rubber pads are fixed to the side walls of the plurality of first semicircular notches (7) and the plurality of second semicircular notches (8).

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