Pressure reduction type liquid degassing equipment for biological medicine

Abstract

The utility model discloses decompression type liquid degassing equipment for biological medicines, and relates to the field of medicine processing equipment. The device comprises a device main body, the top of the device main body is provided with a top opening, the top of the top opening is provided with a sealing mechanism, through the arrangement of the defoaming mechanism, when a sealing cover is closed, an extension rod can be in butt joint with the interior of a threaded groove in a rotating mode, and it is guaranteed that an insertion block is in insertion connection with an insertion groove; after the sealing cover is sealed, the ultrasonic generator can be started through the control panel, and the ultrasonic generator and the vibration sheet on the outer side can vibrate at high frequency, so that the gas can be quickly separated from the liquid and the foam can be eliminated, and the efficiency of the degassing operation is improved; and the vibration sheet can promote the energy of the ultrasonic waves to be more uniformly distributed in a larger area, so that the cleaning range is expanded.

Description

Technical Field

[0001] The utility model relates to the field of drug processing equipment, in particular to a decompression type liquid degassing device for biological medicines. Background Art

[0002] When preparing biological drugs, some types of drugs need to be degassed. This is mainly because bubbles or dissolved gases may be generated during the preparation process, which may affect the stability and effect of the drug. In this case, degassing may be a necessary step to ensure the quality and consistency of the drug. At this time, a decompression type liquid degassing device for biological drugs can be provided.

[0003] Existing decompression type liquid degassing equipment for biological drugs mainly degasses liquid biological drugs by negative pressure suction and heating. The efficiency of expelling bubbles by heating is low, and the active ingredients of some drugs are denatured or inactivated during degassing, thereby affecting the efficacy of the drugs. Therefore, when designing decompression type liquid degassing equipment for biological drugs, it is necessary to provide a degassing mechanism that can more efficiently remove the bubbles inside the liquid drug to facilitate subsequent negative pressure suction, thereby improving the overall practicality. Utility Model Content

[0004] Based on this, the purpose of the utility model is to provide a decompression type liquid degassing device for biological medicines, so as to solve the technical problem that the degassing efficiency of the traditional decompression type liquid degassing device for biological medicines needs to be improved.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a decompression type liquid degassing device for biological drugs, comprising a device body, a top opening is arranged on the top of the device body, a sealing mechanism is installed on the top of the top opening, the sealing mechanism comprises a connecting piece and a sealing cover, a degassing mechanism is arranged on the bottom of the sealing cover, the degassing mechanism comprises a connecting seat, a thread groove is arranged on the bottom of the connecting seat, a slot is arranged inside the thread groove, an extension rod is threadedly connected inside the thread groove, an insert block is arranged on the top of the extension rod, and the insert block is plugged into the slot;

[0006] An ultrasonic generator is arranged at the bottom of the extension rod, and a vibration sheet is arranged on the outer side of the ultrasonic generator.

[0007] By adopting the above technical solution, since a top opening is provided on the top of the device body, a sealing mechanism is installed on the top of the top opening, and the top opening can be effectively sealed by the sealing mechanism to facilitate subsequent negative pressure degassing.

[0008] Furthermore, a power supply line is provided on one side of the connection socket, and the power supply line is connected to an external power source.

[0009] By adopting the above technical solution, since a power supply line is provided on one side of the connection socket, the connection socket can be powered by the power supply line.

[0010] Furthermore, four vibration plates are provided, and the four vibration plates are arranged equidistantly in a ring array.

[0011] By adopting the above technical solution, since four vibration plates are provided, the energy of the ultrasonic wave can be more evenly distributed in a larger area through the vibration plates.

[0012] Furthermore, an inner bin is provided inside the main body of the device, and a check plate is provided above the inner wall of the inner bin.

[0013] By adopting the above technical solution, since an inner bin is provided inside the main body of the device, liquid can be stored and processed through the inner bin.

[0014] Furthermore, the top of the connecting member is rotatably connected to a mounting plate via a rotating seat, and the bottom of the mounting plate is connected to the sealing cover.

[0015] By adopting the above technical solution, since the top of the connecting member is rotatably connected to the mounting plate via the rotating seat, the mounting plate can be rotated.

[0016] Furthermore, a sleeve hole is provided on one side of the sealing cover, a plug-in plate is provided below the sleeve hole, and tightening bolts are threadedly connected on the sleeve hole and the plug-in plate.

[0017] By adopting the above technical solution, since a sleeve hole is provided on one side of the sealing cover and a plug-in plate is provided below the sleeve hole, the tightening bolts can be effectively threadedly connected through the sleeve hole and the plug-in plate, and the tightening bolts are threadedly connected on the sleeve hole and the plug-in plate.

[0018] Furthermore, a support frame is provided at the bottom of the device body, and four support frames are provided, and the four support frames are arranged equidistantly in a circular array.

[0019] By adopting the above technical solution, since a support frame is provided at the bottom of the equipment body, the support frame can keep the equipment at a certain distance from the ground, which is beneficial to the heat dissipation of the equipment. This is very important for degassing equipment that requires a good heat dissipation environment, and can ensure the normal operation of the equipment and extend its service life.

[0020] Furthermore, an air suction port is provided on one side of the device body, and the air suction port is connected to an external negative pressure air pump. A liquid outlet is provided at the bottom of the device body, and the liquid outlet is connected to an external electronic valve. A control panel is provided on the outer surface of the device body.

[0021] By adopting the above technical solution, since an exhaust port is provided on one side of the equipment body, and the exhaust port is connected to an external negative pressure exhaust pump, when the external exhaust pump is started, a negative pressure environment can be formed inside the inner chamber through the exhaust port to facilitate degassing.

[0022] Furthermore, a heater is provided below the inner wall of the inner bin, and a wedge-shaped surface is provided at the bottom of the inner bin.

[0023] By adopting the above technical solution, since a heater is arranged below the inner wall of the inner chamber, for some medicines that need to be heated and degassed, the heater can be started to heat the medicines.

[0024] In summary, the utility model mainly has the following beneficial effects:

[0025] 1. The utility model sets a degassing mechanism. When the sealing cover is closed, the extension rod can be connected to the inside of the threaded groove by rotating, and the plug block and the slot are ensured to be plugged. After the sealing cover is closed, the ultrasonic generator can be started through the control panel. At this time, the ultrasonic generator and the outer vibration plate will vibrate at a high frequency. In this way, the gas can be quickly separated from the liquid and the foam can be eliminated, which improves the efficiency of the degassing operation and reduces the processing time. In addition, this method does not produce harmful substances, does not pollute the environment, and meets environmental protection requirements. The vibration plate can cause the energy of the ultrasonic wave to be more evenly distributed in a larger area, thereby expanding the cleaning range;

[0026] 2. The utility model sets a check plate. When negative pressure degassing is performed, the liquid will be lifted due to the internal pressure difference caused by the negative pressure until the pressure inside and outside the liquid reaches a balance. Although the equipment body will calculate and add the liquid before adding it, bubbles will be generated during degassing. In order to prevent the bubbles from bursting and splashing to higher places in the inner chamber, causing difficulty in cleaning, the check plate can effectively block them, thereby improving the overall practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0028] Figure 2 This is a bottom-up three-dimensional structural schematic diagram of the utility model;

[0029] Figure 3 It is a schematic diagram of a side-view cross-sectional three-dimensional structure of the utility model;

[0030] Figure 4 For this utility model Figure 3 Schematic diagram of the structure enlarged at point A in the middle.

[0031] In the figure: 1. Equipment body; 2. Control panel; 3. Support frame; 4. Air exhaust port; 5. Top port; 6. Sealing mechanism; 601. Connector; 602. Rotating seat; 603. Mounting plate; 604. Hole; 605. Plug-in board; 606. Tightening bolt; 607. Sealing cover; 7. Degassing mechanism; 701. Connecting seat; 702. Power supply line; 703. Extension rod; 704. Threaded groove; 705. Slot; 706. Plug-in block; 707. Ultrasonic generator; 708. Vibrating plate; 8. Inner chamber; 9. Check plate; 10. Heater; 11. Wedge-shaped surface; 12. Liquid outlet. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. The embodiments described below with reference to the drawings are exemplary and are only used to explain the utility model, and cannot be understood as limiting the utility model.

[0033] The following describes an embodiment of the utility model based on its overall structure. Embodiment 1:

[0034] A decompression type liquid degassing device for biological drugs, such as Figure 1-Figure 4 As shown, the device comprises a device body 1, a top opening 5 is provided on the top of the device body 1, a sealing mechanism 6 is installed on the top of the top opening 5, the sealing mechanism 6 comprises a connecting piece 601 and a sealing cover 607, a degassing mechanism 7 is provided at the bottom of the sealing cover 607, the degassing mechanism 7 comprises a connecting seat 701, a threaded groove 704 is provided at the bottom of the connecting seat 701, a slot 705 is provided inside the threaded groove 704, an extension rod 703 is threadedly connected inside the threaded groove 704, an insert block 706 is provided on the top of the extension rod 703, the insert block 706 is plugged into the slot 705, and a degassing mechanism 7 is provided at the bottom of the extension rod 703. The ultrasonic generator 707 is provided with a vibrating plate 708 on the outside thereof. The top opening 5 can be effectively sealed by the sealing mechanism 6 to facilitate the subsequent negative pressure degassing. The extension rod 703 can be fixed by rotation through the threaded groove 704. In addition, the vibrating plate 708 vibrates under the excitation of the ultrasonic generator 707, which will induce a cavitation effect. This effect can quickly cause the tiny bubbles in the liquid to expand and burst instantly, thereby efficiently releasing the gas dissolved in the biological drug liquid. This process significantly improves the degassing efficiency of the biological drug liquid.

[0035] See also Figure 1 , Figure 2 , Figure 3 , Figure 4A power supply line 702 is provided on one side of the connection socket 701, and the power supply line 702 is connected to an external power source. The connection socket 701 can be powered by the power supply line 702. When the connection socket 701 is damaged, the power supply line 702 can be unplugged to effectively cut off the power supply for safe maintenance.

[0036] See also Figure 1 , Figure 2 , Figure 3 , Figure 4 There are four vibration pieces 708, which are arranged equidistantly in a circular array. The vibration pieces 708 can make the ultrasonic energy more evenly distributed in a larger area, and the ultrasonic energy generated by the four vibration pieces 708 can be more evenly distributed in the area around the generator. This uniform energy distribution helps to improve the degassing effect. When the four vibration pieces 708 vibrate at the same time, it helps to reduce the dead corners of the biological drug liquid during the processing process, ensuring that the gas in the biological drug liquid can be removed more thoroughly. Embodiment 2:

[0037] See also Figure 1 , Figure 2 , Figure 3 An inner bin 8 is provided inside the equipment body 1, and a check plate 9 is provided on the inner wall of the inner bin 8. Liquid can be stored and processed through the inner bin 8. Bubbles will be generated during the degassing of the biological drug liquid. In order to prevent the bubbles generated during the degassing of the biological drug liquid from bursting and splashing to a higher place in the inner bin 8, causing difficulty in cleaning, the check plate 9 can effectively block them, thereby improving the overall practicality.

[0038] See also Figure 1 , Figure 2 , Figure 3 , Figure 4 The top of the connecting member 601 is rotatably connected to the mounting piece 603 through the rotating seat 602, and the bottom of the mounting piece 603 is connected to the sealing cover 607, so the mounting piece 603 can be rotated, and the sealing cover 607 can be installed through the mounting piece 603, and at the same time, the sealing cover 607 can be driven to rotate.

[0039] See also Figure 1 , Figure 2 , Figure 3 , Figure 4A sleeve hole 604 is provided on one side of the sealing cover 607, and a plug-in plate 605 is provided below the sleeve hole 604. Tightening bolts 606 are threadedly connected on the sleeve hole 604 and the plug-in plate 605. The tightening bolts 606 can be effectively threadedly connected through the sleeve hole 604 and the plug-in plate 605. The sleeve hole 604 and the plug-in plate 605 are threadedly connected with tightening bolts 606, and the sealing cover 607 and the top opening 5 can be closed by the tightening bolts 606.

[0040] See also Figure 1 , Figure 2 , Figure 3 A support frame 3 is provided at the bottom of the equipment body 1. There are four support frames 3, which are equidistantly arranged in a circular array. The support frame 3 can keep the equipment at a certain distance from the ground, which is beneficial to the heat dissipation of the equipment. This is very important for degassing equipment that requires a good heat dissipation environment. It can ensure the normal operation of the equipment and extend its service life. Moreover, the four support frames 3 can provide more stable support relative to fewer support points. The equidistant arrangement of the circular array ensures that the equipment is evenly stressed in all directions, reducing the possibility of tilting or imbalance.

[0041] See also Figure 1 , Figure 2 , Figure 3 A vacuum port 4 is provided on one side of the device body 1, and the vacuum port 4 is connected to an external negative pressure vacuum pump. A liquid outlet 12 is provided at the bottom of the device body 1, and the liquid outlet 12 is connected to an external electronic valve. A control panel 2 is provided on the outer surface of the device body 1. When the external vacuum pump is started, a negative pressure environment can be formed inside the inner chamber 8 through the vacuum port 4 to facilitate degassing work, and the point equipment of the entire device body 1 can be effectively controlled through the control panel 2.

[0042] The implementation principle of the utility model is as follows: first, the device body 1 needs to be installed and powered on, then the top opening 5 can be opened first, then the medicine is introduced into the interior of the inner chamber 8, then the extension rod 703 is connected to the interior of the threaded groove 704 by rotation, and the plug block 706 and the slot 705 are plugged, and then the sealing cover 607 is closed, and the ultrasonic generator 707 can be started through the control panel 2, and then the ultrasonic generator 707 and the outer vibration sheet 708 will vibrate at a high frequency, and in this way, the gas can be quickly separated from the liquid and the foam can be eliminated, which improves the efficiency of the degassing operation;

[0043] Afterwards, when negative pressure degassing is performed, the liquid will be lifted due to the internal pressure difference caused by the negative pressure until the pressure inside and outside the liquid reaches a balance. Although the equipment body 1 will perform calculations before adding the liquid medicine, bubbles will still be generated during degassing. In order to avoid the bubbles bursting and splashing to higher places in the inner chamber 8, causing cleaning difficulties, the check plate 9 can effectively block it, thereby improving the overall practicality.

[0044] Parts not involved in the present invention are the same as the prior art or can be implemented by using the prior art, and will not be described in detail here.

[0045] Although an embodiment of the utility model has been shown and described, this specific embodiment is only an explanation of the utility model and is not a limitation of the utility model. The specific features, structures, materials or characteristics described may be combined in a suitable manner in any one or more embodiments or examples. After reading this specification, those skilled in the art may make modifications, substitutions and variations to the embodiments without creative contribution as needed without departing from the principles and purpose of the utility model. However, as long as they are within the scope of the claims of the utility model, they are protected by patent law.

Claims

1. A decompression type liquid degassing device for biological drugs, characterized in that: The device comprises a device body (1), wherein a top opening (5) is arranged at the top of the device body (1), a sealing mechanism (6) is installed at the top of the top opening (5), the sealing mechanism (6) comprises a connecting piece (601) and a sealing cover (607), a degassing mechanism (7) is arranged at the bottom of the sealing cover (607), the degassing mechanism (7) comprises a connecting seat (701), a thread groove (704) is arranged at the bottom of the connecting seat (701), a slot (705) is arranged inside the thread groove (704), an extension rod (703) is threadedly connected inside the thread groove (704), an insert block (706) is arranged at the top of the extension rod (703), and the insert block (706) is plugged into the slot (705); An ultrasonic generator (707) is arranged at the bottom of the extension rod (703), and a vibration sheet (708) is arranged on the outside of the ultrasonic generator (707).

2. The decompression type liquid degassing device for biological drugs according to claim 1, characterized in that: A power supply line (702) is provided on one side of the connection base (701), and the power supply line (702) is connected to an external power source.

3. The decompression type liquid degassing device for biological drugs according to claim 1, characterized in that: Four vibration plates (708) are provided, and the four vibration plates (708) are arranged equidistantly in a circular array.

4. The decompression type liquid degassing device for biological drugs according to claim 1, characterized in that: An inner bin (8) is provided inside the device body (1), and a check plate (9) is provided above the inner wall of the inner bin (8).

5. The decompression type liquid degassing device for biological drugs according to claim 1, characterized in that: The top of the connecting member (601) is rotatably connected to a mounting plate (603) via a rotating seat (602), and the bottom of the mounting plate (603) is connected to a sealing cover (607).

6. The decompression type liquid degassing device for biological drugs according to claim 1, characterized in that: A sleeve hole (604) is provided on one side of the sealing cover (607), a plug-in plate (605) is provided below the sleeve hole (604), and tightening bolts (606) are threadedly connected on the sleeve hole (604) and the plug-in plate (605).

7. The decompression type liquid degassing device for biological drugs according to claim 1, characterized in that: A support frame (3) is provided at the bottom of the device body (1), and four support frames (3) are provided, and the four support frames (3) are arranged equidistantly in a circular array.

8. The decompression type liquid degassing device for biological drugs according to claim 1, characterized in that: A vacuum port (4) is provided on one side of the device body (1), and the vacuum port (4) is connected to an external negative pressure vacuum pump. A liquid outlet (12) is provided at the bottom of the device body (1), and the liquid outlet (12) is connected to an external electronic valve. A control panel (2) is provided on the outer surface of the device body (1).

9. The decompression type liquid degassing device for biological drugs according to claim 4, characterized in that: A heater (10) is provided below the inner wall of the inner bin (8), and a wedge-shaped surface (11) is provided at the bottom of the inner bin (8).

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