Chip crimping device for gene sequencer

Abstract

The utility model relates to a chip crimping device for a gene sequencer, which comprises a bottom plate and a fixed seat, the fixed seat is arranged on the bottom plate, the front surface of the fixed seat is provided with a sliding block capable of sliding up and down, the back surface of the fixed seat is provided with a knob, the knob can drive the sliding block to slide downwards through a transmission piece, and two ends of the bottom of the sliding block are provided with springs capable of abutting against the bottom plate. A floating block located below the fixing base is arranged on the back face of the sliding block, a positioning pin corresponding to a positioning hole in the chip is arranged at the bottom of the floating block, a sealing plug upwards penetrating through the floating block is further arranged at the bottom of the floating block, and a through hole is formed in the sealing plug. When the sliding block slides downwards, the sealing plug can be driven to make sealing contact with the chip and drive the through hole to be communicated with the liquid inlet hole in the chip. The device has the beneficial effects that the requirement for separating a sequencing reagent from a sequencing chip can be met, and the sequencing chip is supported to be mounted and reused after being dismounted from an instrument for multiple times, so that the use cost is reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of gene sequencing, and in particular relates to a chip pressing device for a gene sequencer. Background Art

[0002] The sequencing chips of the common gene sequencers on the market currently have sequencing reagents integrated with the sequencing chips for single use, or they are compacted by a motor and are equipped with complex reagent kit devices.

[0003] Since the sequencing chip-related structure of existing sequencers is complex and the cost of use is high, the sequencing kit and sequencing chip must be tested once after being installed on the machine, and cannot be separated midway and then continued for sequencing, making it inconvenient to reuse. Utility Model Content

[0004] The purpose of the utility model is to overcome the shortcomings of the prior art and provide a chip crimping device for a gene sequencer, which can meet the separation requirements of sequencing reagents and sequencing chips, and support the sequencing chips to be removed from the instrument and then installed and reused multiple times, thereby reducing the cost of use.

[0005] The purpose of the utility model is achieved through the following technical solutions:

[0006] A chip crimping device for a gene sequencer comprises a base plate and a fixing seat, wherein the fixing seat is arranged on the base plate, a slider which can slide up and down is arranged on the front of the fixing seat, a knob is arranged on the back of the fixing seat, the knob can drive the slider to slide downward through a transmission member, springs which can abut against the base plate are arranged at both ends of the bottom of the slider, a floating block which is located below the fixing seat is arranged on the back of the slider, a positioning pin corresponding to a positioning hole on the chip is arranged at the bottom of the floating block, a sealing plug which passes through the floating block upward is also arranged at the bottom of the floating block, a through hole is arranged on the sealing plug, and when the slider slides downward, the sealing plug can be driven to seal and contact with the chip and the through hole can be driven to communicate with a liquid inlet hole on the chip.

[0007] Furthermore, the fixing seat is of a door-shaped structure, the legs at both ends of the fixing seat are arranged on the bottom plate, and the floating block is located below the crossbeam of the fixing seat.

[0008] Furthermore, an upright linear slide rail is provided on the front side of the support leg of the fixed seat, and a slide seat slidably connected to the linear slide rail is provided on the slide block.

[0009] Furthermore, the transmission part includes a pressure block, a Z-shaped shaft and an externally threaded bearing. The pressure block is arranged on the slider. A transverse sliding hole is provided on the pressure block. One end of the Z-shaped shaft is rotatably connected to the crossbeam of the fixed seat and connected to the knob. The other end of the Z-shaped shaft is connected to the externally threaded bearing and is slidably connected to the transverse sliding hole through the externally threaded bearing.

[0010] Furthermore, a groove is formed on the top surface of the slider, extending downward to the top surface of the floating block and corresponding to the sealing plug.

[0011] Furthermore, a countersunk hole corresponding to the spring is provided on the bottom plate, and the spring can be inserted into the countersunk hole.

[0012] Compared with the prior art, the utility model has the following beneficial effects:

[0013] 1. The utility model arranges structures such as a slider, a knob and a floating block, so that the chip and the reagent can be separated by simply turning the knob, thereby supporting the chip to be removed from the gene sequencer and then installed and reused multiple times, and the functional adaptability is stronger.

[0014] 2. The utility model can realize self-locking and clamping through the mechanical structure, without the need for additional parts such as motors to assist in operation. The overall structure is simple and reliable, and the use cost is low. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0016] Figure 2 This is a schematic diagram of the overall structure of the utility model after removing the bottom plate;

[0017] Figure 3 for Figure 2 Schematic diagram of the bottom structure.

[0018] In the figure: 1, base plate; 2, fixed seat; 3, slider; 4, knob; 5, spring; 6, floating block; 7, positioning pin; 8, sealing plug; 9, linear guide rail; 10, slide seat; 11, pressure block; 12, Z-axis; 13, external threaded bearing; 14, transverse slide hole; 15, groove. DETAILED DESCRIPTION

[0019] The present invention is further described below in conjunction with the accompanying drawings, but the protection scope of the present invention is not limited to the following description.

[0020] like Figure 1 As shown, a chip crimping device for a gene sequencer comprises a base plate 1 and a fixing seat 2. The base plate 1 can be installed on the gene sequencer, the fixing seat 2 is a door-shaped structure, and the legs at both ends of the fixing seat 2 are fixed on the base plate 1.

[0021] like Figure 2 , Figure 3As shown, a slider 3 that can slide up and down is provided on the front of the fixed seat 2, and a knob 4 is provided on the back of the fixed seat 2. The knob 4 can drive the slider 3 to slide downward through a transmission member. Springs 5 ​​that can abut against the bottom plate 1 are fixed at both ends of the bottom of the slider 3. A floating block 6 located below the crossbeam of the fixed seat 2 is provided on the back of the slider 3. The floating block 6 is preferably integrally formed with the slider 3. A positioning pin 7 corresponding to the positioning hole on the chip is fixed at the bottom of the floating block 6. A sealing plug 8 that penetrates the floating block 6 upward is also provided at the bottom of the floating block 6. The sealing plug 8 is embedded in the floating block 6, and a through hole is opened on the sealing plug 8. When the slider 3 slides downward, it can drive the floating block 6 to move downward, and drive the positioning pin 7 to insert into the corresponding positioning hole on the chip, thereby positioning the chip. At the same time, it can drive the sealing plug 8 to seal with the chip and connect the through hole with the liquid inlet hole on the chip. After the gene sequencer is connected to the sealing plug 8 through an external pipeline, the reagents in the gene sequencer can be transported to the chip. The sealing plug 8 can play a role in sealing and leakproofing during the reagent transportation process.

[0022] like Figure 2 As shown, an upright linear slide rail 9 is fixed on the front side of the support leg of the fixed seat 2, and a slide seat 10 slidably connected to the linear slide rail 9 is fixed on the slider 3, so that the slider 3 can move up and down under the sliding cooperation of the slide seat 10 and the linear slide rail 9.

[0023] like Figure 2 As shown, the transmission member includes a pressing block 11, a Z-shaped shaft 12 and an externally threaded bearing 13. The pressing block 11 is fixed on the slider 3, and a transverse sliding hole 14 is provided on the pressing block 11. One end of the Z-shaped shaft 12 is rotatably connected to the crossbeam of the fixed seat 2 through a bearing and other connecting parts and fixedly connected to the knob 4. The other end of the Z-shaped shaft 12 is connected to the externally threaded bearing 13 and is slidably connected to the transverse sliding hole 14 through the externally threaded bearing 13. The Z-shaped shaft 12 can be driven to rotate by rotating the knob 4, and then the externally threaded bearing 13 can be driven to slide in the transverse sliding hole 14, so that the externally threaded bearing 13 can press down the pressing block 11 when sliding, and then the slider 3 is driven to move downward along the linear slide rail 9 through the pressing block 11. During the downward sliding of the slider 3, the spring 5 abuts against and is compressed against the base plate 1. When the locating pin 7 is plugged into the corresponding locating hole on the chip and the sealing plug 8 is in sealing contact with the chip, the knob 4 is loosened and the elastic force of the spring 5 reacts on the external threaded bearing 13, thereby tightening the external threaded bearing 13 so that the external thread cannot move freely. In this way, the sealing plug 8 can maintain a sealing contact state with the chip, achieving self-locking compression.

[0024] Preferably, Figure 2 As shown, a groove 15 extending downward to the top surface of the floating block 6 and corresponding to the sealing plug 8 is provided on the top surface of the slider 3. The provision of the groove 15 facilitates the connection of the external pipeline from the top of the slider 3 to the sealing plug 8. In addition, a countersunk hole corresponding to the spring 5 is provided on the bottom plate 1, and the spring 5 can be inserted into the countersunk hole to prevent the spring 5 from bending when it contacts the bottom plate 1.

[0025] The working principle of the utility model is as follows:

[0026] Connect the sealing plug 8 to the gene sequencer through an external pipeline, place the chip on the base plate 1 and make it located under the crossbeam of the fixing seat 2, then turn the knob 4 to move the slider 3 together with the floating block 6 downward, so that the positioning pin 7 is inserted into the positioning hole on the chip to position the chip, and continue to turn the knob 4 until the sealing plug 8 is in sealing contact with the chip. At this time, the through hole on the sealing plug 8 is connected with the liquid inlet hole on the chip, and the spring 5 is inserted into the countersunk hole of the base plate 1 and compressed. Then the reagent in the gene sequencer can be transported to the chip and the sequencing operation can be performed. After the sequencing is completed, turn the knob 4 in the opposite direction. Under the restoring force of the spring 5, the slider 3 together with the floating block 6 automatically moves upward and resets, thereby driving the positioning column and the sealing plug 8 to disengage from the chip. Then the chip can be taken out. When sequencing is needed again, the above operation process can be repeated.

[0027] Based on the above-mentioned chip crimping device for gene sequencers and its working principle, the utility model arranges structures such as a slider 3, a knob 4 and a floating block 6, so that the chip and the reagent can be separated by simply turning the knob 4, thereby supporting the chip to be removed from the gene sequencer and then installed and reused multiple times, with stronger functional adaptability. During operation, self-locking and clamping can be achieved through a mechanical structure, without the need for additional components such as motors to assist in the operation. The overall structure is simple and reliable, and the cost of use is low.

[0028] Finally, although the above description has shown and described the embodiments of the present invention, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A chip crimping device for a gene sequencer, characterized in that: The invention comprises a bottom plate (1) and a fixing seat (2), wherein the fixing seat (2) is arranged on the bottom plate (1), a slider (3) which can slide up and down is arranged on the front of the fixing seat (2), a knob (4) is arranged on the back of the fixing seat (2), the knob (4) can drive the slider (3) to slide downward through a transmission member, springs (5) which can abut against the bottom plate (1) are arranged at both ends of the bottom of the slider (3), a floating block (6) which is located below the fixing seat (2) is arranged on the back of the slider (3), a positioning pin (7) corresponding to a positioning hole on a chip is arranged at the bottom of the floating block (6), a sealing plug (8) which penetrates the floating block (6) upwards is also arranged at the bottom of the floating block (6), a through hole is arranged on the sealing plug (8), and when the slider (3) slides downward, the sealing plug (8) can be driven to seal and contact with the chip and drive the through hole to communicate with the liquid inlet hole on the chip.

2. The chip pressing device for a gene sequencer according to claim 1, characterized in that: The fixed seat (2) is of a door-shaped structure, the legs at both ends of the fixed seat (2) are arranged on the bottom plate (1), and the floating block (6) is located below the crossbeam of the fixed seat (2).

3. The chip pressing device for a gene sequencer according to claim 2, characterized in that: A vertical linear slide rail (9) is provided on the front side of the support leg of the fixed seat (2), and a slide seat (10) slidably connected to the linear slide rail (9) is provided on the slide block (3).

4. The chip pressing device for a gene sequencer according to claim 2, characterized in that: The transmission member comprises a pressing block (11), a Z-shaped shaft (12) and an externally threaded bearing (13); the pressing block (11) is arranged on a slider (3); a transverse sliding hole (14) is arranged on the pressing block (11); one end of the Z-shaped shaft (12) is rotatably connected to a crossbeam of a fixed seat (2) and connected to a knob (4); the other end of the Z-shaped shaft (12) is connected to the externally threaded bearing (13) and is slidably connected to the transverse sliding hole (14) through the externally threaded bearing (13).

5. The chip pressing device for a gene sequencer according to claim 1, characterized in that: The top surface of the sliding block (3) is provided with a groove (15) extending downward to the top surface of the floating block (6) and corresponding to the sealing plug (8).

6. The chip pressing device for a gene sequencer according to claim 1, characterized in that: A countersunk hole corresponding to the spring (5) is provided on the bottom plate (1), and the spring (5) can be inserted into the countersunk hole.

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