Isolated heart experiment platform

Abstract

The utility model discloses an isolated heart experiment platform which comprises a supporting column assembly, a supporting basin arranged on the supporting column assembly, a supporting frame connected with the supporting column assembly in a matched mode, an extrusion mechanism movably connected to the supporting frame through a hinged support assembly and capable of rotating up and down along the supporting frame, and a control module in communication connection with the extrusion mechanism. The extrusion mechanism comprises a driving assembly movably arranged on the supporting frame and an extrusion assembly which is connected to the output end of the driving assembly in a matched mode and reciprocates towards the interior of the supporting basin, a pressure sensor is arranged on the extrusion assembly, and the extrusion assembly is driven by the driving assembly to reciprocate. And then the isolated heart in the supporting basin is extruded. According to the experimental platform, accurate control over the heart extrusion link in the isolated heart perfusion technology is achieved, meanwhile, long-time and stable pace-making on the isolated heart is achieved, a new experimental means is provided for treatment and research of heart diseases, and deep research and understanding of the physiological mechanism of the heart are facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of medical experimental equipment, in particular to an isolated heart experimental platform. Background Art

[0002] Isolated heart perfusion technology is one of the key technologies for isolated heart experiments. This technology removes the animal heart from the body and places it in a specific perfusion fluid for perfusion, thereby simulating the normal physiological environment of the heart. The development of isolated heart perfusion technology provides a crucial experimental approach for cardiac physiology research. In the isolated perfusion system, the heart is connected to the external perfusion device through the aorta and vein, and the perfusion fluid circulates in the heart blood vessels to deliver oxygen and nutrients to the heart. By adjusting the flow rate, pressure, temperature and other parameters of the perfusion fluid, different physiological and pathological states can be simulated, and then the heart function and its regulatory mechanism can be explored.

[0003] In terms of heart compression, a key step in isolated heart perfusion technology, there is no structure in the prior art that is specifically designed to perform accurate and effective compression on isolated hearts. Therefore, it is necessary to design a mechanical structure that can perform heart compression according to a preset frequency and force. Utility Model Content

[0004] In order to solve the above technical problems, the utility model provides an isolated heart experimental platform.

[0005] The utility model solves the above technical problems with the following technical solutions: an isolated heart experimental platform, comprising a support assembly, a support basin arranged on the support assembly, a support frame connected with the support assembly, an extrusion mechanism movably connected to the support frame through a hinge assembly and capable of rotating up and down along the support frame, and a control module connected to the extrusion mechanism in communication, wherein the telescopic extrusion end of the extrusion mechanism faces the inside of the support basin;

[0006] The extrusion mechanism includes a driving component movably arranged on a support frame and an extrusion component connected to the output end of the driving component and reciprocating toward the inside of the support basin. A pressure sensor is arranged on the extrusion component. The pressure sensor and the driving component are respectively communicated with the control module. The driving component drives the extrusion component to reciprocate, thereby squeezing the isolated heart in the support basin.

[0007] Furthermore, the driving assembly includes a push rod stepper motor and a coupling connected to the output end of the push rod stepper motor, and the extrusion assembly is connected to the end face of the coupling.

[0008] Furthermore, the extrusion assembly includes a transmission joint, an extrusion joint arranged on the end surface of the transmission joint, and a pressure strip arranged on the end surface of the extrusion joint, and the transmission joint is arranged on the output shaft of the driving assembly.

[0009] Furthermore, the hinge seat assembly includes an outer hinge seat arranged on a support frame, a hinge seat center groove and a hinge seat motion groove in an arc-shaped structure respectively arranged on the outer hinge seat, and an inner hinge seat hinged inside the outer hinge seat. The screw on the hinge seat center groove is used as a fulcrum to make the inner hinge seat rotate up and down with the hinge seat center groove as the center. One end of the push rod stepper motor is connected to the inner hinge seat through a fixed block.

[0010] Furthermore, a limit switch fixing block is arranged at the end of the push rod stepper motor near the output end, and a limit switch is arranged on the limit switch fixing block. When the push rod stepper motor drives the extrusion assembly to retreat, the limit switch is touched, and the limit switch is communicatively connected with the control module.

[0011] Furthermore, the support assembly includes a support, a column arranged on the support through a cross connection block, and a support plate arranged on the column, and the tray is arranged on the support plate.

[0012] Furthermore, the support frame includes a support cross column arranged on the column and a support vertical column arranged on the support cross column through a cross connection block, and the external hinge seat is arranged on the support vertical column.

[0013] Furthermore, a tray for placing the isolated heart is arranged inside the tray.

[0014] Furthermore, the control module includes a motor controller, a single-chip computer system, a power supply system, and a component control system.

[0015] The utility model has the following beneficial effects: the isolated heart experimental platform provided by the invention has a reliable structure and good performance, and can realize precise control of the heart compression link in the isolated heart perfusion technology, while realizing long-term and stable pacing of the isolated heart, providing a new experimental means for the treatment and research of heart diseases, and contributing to a deeper study and understanding of the physiological mechanism of the heart. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the structure of the utility model;

[0017] Figure 2 It is a side view of the utility model;

[0018] Figure 3 It is a side sectional view of the utility model;

[0019] Figure 4 This is a front cross-sectional view of the utility model;

[0020] Figures 1 to 4The reference numerals shown in the figures represent respectively: 1-pillar assembly, 2-tray, 3-support frame, 4-hinge assembly, 5-extrusion mechanism, 6-control module, 50-drive assembly, 51-extrusion assembly, 52-pressure sensor, 500-push rod stepper motor, 501-coupling, 510-transmission joint, 511-extrusion joint, 512-pressure strip, 40-external hinge, 41-hinge center groove, 42-hinge motion groove, 43-inner hinge, 502-limit switch fixing block, 503-limit switch, 10-support, 11-cross connecting block, 12-column, 13-pillar plate, 30-support horizontal column, 31-support vertical column, 20-tray. DETAILED DESCRIPTION

[0021] The principles and features of the present invention are described below in conjunction with the accompanying drawings. The examples given are only used to explain the present invention and are not used to limit the scope of the present invention.

[0022] like Figures 1 to 4 As shown, an isolated heart experimental platform includes a support assembly 1, a support basin 2 arranged on the support assembly 1, a support frame 3 connected to the support assembly 1, an extrusion mechanism 5 movably connected to the support frame 3 through a hinge assembly 4 and capable of rotating up and down along the support frame 3, and a control module 6 connected to the extrusion mechanism 5 in communication, and the telescopic extrusion end of the extrusion mechanism 5 faces the inside of the support basin 2. The support basin 2 is equipped with a tray 20 for placing an isolated heart, and the extrusion mechanism 5 can adjust the angle according to the position of the isolated heart on the tray 20, so that the extrusion mechanism 5 can accurately perform an extrusion experiment operation on the isolated heart. The control module 6 adopts an existing control system, which includes a motor controller, a single-chip computer system, a power supply system, and a component control system. The control module 6 sets a preset threshold and a feedback signal of a sensor, and controls the drive component to perform corresponding driving operations according to these signals.

[0023] The squeezing mechanism 5 includes a driving assembly 50 movably arranged on the support frame 3 and a squeezing assembly 51 which is connected to the output end of the driving assembly 50 and reciprocates toward the inside of the tray 2. A pressure sensor 52 is arranged on the squeezing assembly 51. The pressure sensor 52 and the driving assembly 50 are respectively connected to the control module 6 for communication. The driving assembly 50 drives the squeezing assembly 51 to reciprocate, thereby squeezing the isolated heart in the tray 2. The driving assembly 50 performs reciprocating drive, and its structure is similar to that of an electric cylinder. In the present application, the driving assembly 50 includes a push rod stepper motor 500 and a coupling 501 which is connected to the output end of the push rod stepper motor 500. The squeezing assembly 51 is connected to the end face of the coupling 501. The push rod stepper motor 500 is a device that can convert pulse signals into linear motion. Under the drive of the push rod stepper motor 500, the coupling 501 and the extrusion assembly 51 are driven to perform forward and backward or telescopic reciprocating motion. Under this reciprocating motion, the extrusion assembly 51 squeezes the isolated heart. At the same time, the strength and frequency of the heart squeezing can be preset according to the control module 6. The pressure sensor 52 is used to monitor the pressure value during the heart squeezing process in real time. When the pressure value exceeds or falls below the preset threshold, the sensor will send a signal to the control module 6, and the control module 6 will adjust the rotation state of the stepper motor accordingly to maintain the stability of the pressure and achieve a reliable squeezing effect.

[0024] The extrusion assembly 51 includes a transmission joint 510, an extrusion joint 511 arranged on the end face of the transmission joint 510, and a pressure strip 512 arranged on the end face of the extrusion joint 511. The transmission joint 510 is arranged on the output shaft of the driving assembly 50. Under the driving action of the push rod stepper motor 500, the transmission joint 510, the extrusion joint 511 and the pressure strip 512 are driven to perform synchronous reciprocating motion. Specifically, the push rod stepper motor 500 drives the power transmission joint 510 to move, one end of the pressure sensor 52 is connected to the force transmission joint 510 through a sinking screw, and the other end is connected to the extrusion joint 511, so that the force of the object extrusion is transmitted to the pressure sensor 52 through the extrusion joint 511, and then transmitted to the control module 6 through the data line. The pressure strip 512 is connected to the extrusion joint 511 through the sinking screw, which can prevent hard objects from directly colliding with the extruded object, and its surface spring structure can well achieve a direct buffer structure between the object and the device. In addition, a limit switch fixing block 502 is provided at the end of the push rod stepper motor 500 near the output end, and a limit switch 503 is provided on the limit switch fixing block 502. When the push rod stepper motor 500 drives the extrusion assembly 51 to retreat, the limit switch 503 is touched, and the limit switch 503 is connected to the control module 6. The limit switch 503 is used to determine the starting point of the stepper motor. When the system is powered on, the stepper motor retreats to the limit switch 503, which is the starting point of the motor.

[0025] During the use of the device, the isolated heart needs to be placed in the tray 20, and the relevant extrusion parameters are set in the control module 6. The push rod stepper motor 50014 is rotated and adjusted around the motion groove 12 of the outer hinge seat 40, and the pressure strip 512 is aligned with the isolated heart part that needs to be squeezed to start the extrusion program. At this time, the control module 6 controls the push rod stepper motor 500 to start, driving the rigid coupling 501 to move forward and backward. When reaching the limit position, the rigid coupling 501 will trigger the limit switch 503 signal and transmit the signal to the control module 6. At this time, the push rod stepper motor 500 will drive the coupling 501 to move forward. When the pressure strip 512 contacts and collides with the isolated heart, the extrusion joint 511 will transmit the collision extrusion force to the force sensor for data collection and sending to the control module 6. When the preset value is reached, the control module 6 will control the push rod stepper motor 500 to move backward until the limit switch 503 signal is triggered to complete a round of work.

[0026] In order to improve the convenience of adjusting the rotation angle of the extrusion mechanism 5, in the utility model, the hinge seat assembly 4 includes an outer hinge seat 40 arranged on the support frame 3, a hinge seat center groove 41 and a hinge seat movement groove 42 with an arc-shaped structure respectively arranged on the outer hinge seat 40, and an inner hinge seat 43 hinged to the inside of the outer hinge seat 40. The screw on the hinge seat center groove 41 is used as a fulcrum to make the inner hinge seat 43 rotate up and down with the hinge seat center groove 41 as the center, and one end of the push rod stepper motor 500 is connected to the inner hinge seat 43 through a fixed block.

[0027] In order to improve the overall structural stability of the experimental platform, in the utility model, the support assembly 1 includes a support 10, a column 12 arranged on the support 10 through a cross connection block 11, and a support plate 13 arranged on the column 12, and the support basin 2 is arranged on the support plate 13. The lower half of the column 12 is inserted into the center of the support 10 and is fixed by screws, the middle part of the column 12 is installed with a cross connection block 11 for connecting the cross column, and the upper half of the column 12 is installed with the support plate 13 and is fixed by screws. The upper end of the support plate 13 is connected to the bottom end of the support basin 2 seat by a fitting structure, and screws can be locked from the support plate 13 to ensure a stable connection. The support frame 3 includes a support cross column 30 arranged on the column 12 and a support vertical column 31 arranged on the support cross column 30 through a cross connection block 11, and the external hinge seat 40 is arranged on the support vertical column 31. One end of the supporting horizontal column is connected to the cross connecting block 11 for fixing, and the other end is connected to the left side of the cross connecting block 11. The right side of the cross connecting block 11 is connected to the lower half of the supporting vertical column through and through, and the connecting piece is fastened with screws to prevent loosening.

[0028] The above scheme can realize precise control of the heart compression link in the isolated heart perfusion technology, and can achieve long-term and stable pacing of the isolated heart, providing a new experimental means for the treatment and research of heart diseases, and helping to more deeply study and understand the physiological mechanism of the heart.

[0029] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An isolated heart experimental platform, characterized in that: It comprises a support assembly (1), a support basin (2) arranged on the support assembly (1), a support frame (3) connected to the support assembly (1), an extrusion mechanism (5) movably connected to the support frame (3) through a hinge assembly (4) and capable of rotating up and down along the support frame (3), and a control module (6) connected to the extrusion mechanism (5) in communication, wherein the telescopic extrusion end of the extrusion mechanism (5) faces the interior of the support basin (2); The squeezing mechanism (5) comprises a driving component (50) movably arranged on the support frame (3) and a squeezing component (51) connected to the output end of the driving component (50) and reciprocating toward the inside of the support basin (2); a pressure sensor (52) is arranged on the squeezing component (51); the pressure sensor (52) and the driving component (50) are respectively connected to the control module (6) for communication; the driving component (50) drives the squeezing component (51) to reciprocate, thereby squeezing the isolated heart in the support basin (2).

2. The isolated heart experimental platform according to claim 1, characterized in that: The driving assembly (50) comprises a push rod stepper motor (500) and a coupling (501) cooperatively connected to the output end of the push rod stepper motor (500), and the extrusion assembly (51) is cooperatively connected to the end surface of the coupling (501).

3. The isolated heart experimental platform according to claim 1, characterized in that: The extrusion assembly (51) comprises a transmission joint (510), an extrusion joint (511) arranged on the end surface of the transmission joint (510), and a pressure strip (512) arranged on the end surface of the extrusion joint (511); the transmission joint (510) is arranged on the output shaft of the driving assembly (50).

4. The isolated heart experimental platform according to claim 2, characterized in that: The hinge assembly (4) includes an outer hinge (40) arranged on the support frame (3), a hinge center groove (41) and an arc-shaped hinge motion groove (42) respectively arranged on the outer hinge (40), and an inner hinge (43) hinged inside the outer hinge (40). The screw on the hinge center groove (41) is used as a fulcrum to make the inner hinge (43) rotate up and down with the hinge center groove (41) as the center. The push rod stepper motor (500) is connected to the inner hinge (43).

5. The isolated heart experimental platform according to claim 4, characterized in that: A limit switch fixing block (502) is arranged at the end of the push rod stepper motor (500) close to the output end, and a limit switch (503) is arranged on the limit switch fixing block (502). When the push rod stepper motor (500) drives the extrusion assembly (51) to retreat, the limit switch (503) is touched, and the limit switch (503) is communicatively connected with the control module (6).

6. The isolated heart experimental platform according to claim 4, characterized in that: The support assembly (1) comprises a support (10), a column (12) arranged on the support (10) via a cross connection block (11), and a support plate (13) arranged on the column (12), and the tray (2) is arranged on the support plate (13).

7. The isolated heart experimental platform according to claim 6, characterized in that: The support frame (3) comprises a support cross column (30) arranged on the upright column (12) and a support vertical column (31) arranged on the support cross column (30) via a cross connection block (11), and the external hinge seat (40) is arranged on the support vertical column (31).

8. The isolated heart experimental platform according to any one of claims 1 to 7, characterized in that: A tray (20) for placing an isolated heart is arranged inside the support basin (2).

9. The isolated heart experimental platform according to claim 1, characterized in that: The control module (6) comprises a motor controller, a single-chip computer system, a power supply system, and a component control system.

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