Reaction kettle for polypeptide drug production

Abstract

The utility model relates to the technical field of reaction kettles, in particular to a reaction kettle for polypeptide drug production, which comprises a reaction kettle shell, an upper cover is fixedly clamped at the upper end of the reaction kettle shell, fixed circular rings are fixedly connected to the lower part of the upper cover and the upper part of the reaction kettle shell in a penetrating manner, and a plurality of groups of fixed holes are formed in the two fixed circular rings. Fixing bolts are fixedly inserted among a plurality of groups of fixing holes in the two fixing circular rings, an external protection shell is fixedly connected to the outer surface of the reaction kettle shell, a heat preservation mechanism sleeves the outer end of the external protection shell, and a stirring cleaning structure is fixedly connected to the middle of the upper end of the upper cover. The left part of the upper end of the upper cover and the right part of the upper end of the upper cover are fixedly connected with a plurality of groups of feed ports; and the middle part of the lower end of the reaction kettle shell is fixedly connected with a discharge port. According to the reaction kettle for polypeptide drug production, heat preservation can be carried out on the reaction kettle, energy is saved, and raw materials in the reaction kettle can be stirred and cleaned.

Description

Technical Field

[0001] The utility model relates to the technical field of reactors, in particular to a reactor for producing polypeptide drugs. Background Art

[0002] Polypeptides are a class of compounds formed by multiple amino acids connected by peptide bonds, usually composed of 10-100 amino acid molecules, and their connection method is the same as that of proteins. The relative molecular mass is less than 10,000. Polypeptide drugs are drugs produced by this type of compound. Reactors are generally used in the production of polypeptide drugs. There are at least the following disadvantages in the use of existing reactors: 1. Existing reactors generally have high temperature requirements when in use. Traditional reactors cannot save energy when in use, causing excessive diffusion of internal heat to the outside, thus causing energy waste; 2. Existing reactors generally have a stirring structure added inside to facilitate the mixing of raw materials, but after the reactor is used, it is inconvenient to clean the inside. Therefore, we have launched a new reactor for the production of polypeptide drugs. Utility Model Content

[0003] The main purpose of the utility model is to provide a reaction kettle for producing polypeptide drugs, which can effectively solve the problems in the background technology.

[0004] In order to achieve the above purpose, the technical solution adopted by the utility model is:

[0005] A reactor for producing polypeptide drugs comprises a reactor shell, an upper cover is fixedly connected to the upper end of the reactor shell, a fixing ring is inserted and fixedly connected to the lower part of the upper cover and the upper part of the reactor shell, a plurality of fixing holes are opened on the two fixing rings, fixing bolts are inserted and fixed between the plurality of fixing holes on the two fixing rings, an external protective shell is fixedly connected to the outer surface of the reactor shell, a heat preservation mechanism is sleeved on the outer end of the external protective shell, a stirring and cleaning structure is fixedly connected to the middle part of the upper end of the upper cover, a plurality of feed ports are fixedly connected to the left part of the upper end and the right part of the upper end of the upper cover, a discharge port is fixedly connected to the middle part of the lower end of the reactor shell, and a plurality of supporting legs are arranged in a circular array at the lower end of the reactor shell.

[0006] Preferably, the heat-insulating mechanism comprises an outer ring, the inner wall of the outer ring is fixedly connected with a heat-insulating ring, and the inner wall of the heat-insulating ring is fixedly connected with a fitting ring.

[0007] Preferably, the stirring structure is in contact with the inner wall of the reactor shell but is not fixed, and a vacuum state is formed between the inside of the external protection structure and the reactor shell.

[0008] Preferably, the outer ring is made of nylon, the insulation ring is insulation foam, and the fitting ring is elastic.

[0009] Preferably, the stirring and cleaning structure includes a rotating motor, the output end of the rotating motor is fixedly connected to a connecting rod, the left end of the outer surface of the connecting rod and the right end of the outer surface are fixedly connected to rectangular plates, the ends of the two rectangular plates that are not in contact with the connecting rod are fixedly connected to a scraper No. 1, several groups of rectangular grooves are opened on the two rectangular plates, a stabilizing rod is fixedly connected between the upper and lower parts of the two rectangular plates, and a scraper No. 2 is fixedly connected to the lower ends of the two rectangular plates.

[0010] Preferably, the first scraper is a triangular prism structure, the second scraper is a circular arc plate structure, and the stabilizing rod is a circular arc structure.

[0011] Preferably, the first scraper and the second scraper are both in contact with the inner wall of the reactor shell but are not fixed, and the rotating motor is fixedly connected to the upper cover.

[0012] Compared with the prior art, the utility model has the following beneficial effects:

[0013] 1. By setting up an external protective shell and a heat preservation mechanism, there is a vacuum state between the external protective shell and the reactor shell, which can slow down the heat dissipation, and the heat preservation ring on the heat preservation mechanism is a heat preservation cotton that can isolate the heat emitted from the reactor shell from the outside world, and further slow down the heat dissipation, and the outer layer ring is made of nylon material, which can increase the wear resistance, and the internal fitting ring is elastic and can be conveniently sleeved on the outer end of the external protective shell;

[0014] 2. By setting up a stirring and cleaning structure, the rectangular plate on the stirring and cleaning structure rotates with the connecting rod to stir and mix the raw materials inside the reactor shell, and the scraper No. 1 and scraper No. 2 fixedly connected to the rectangular plate can scrape and clean the inner wall of the reactor shell, without the need for subsequent manual cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a partial structural schematic diagram of a reaction kettle for producing polypeptide drugs according to the utility model;

[0016] Figure 2 This is a partial structural schematic diagram of a reaction kettle for producing polypeptide drugs according to the utility model;

[0017] Figure 3 This is a schematic diagram of the overall structure of a stirring and cleaning structure of a reaction kettle for producing polypeptide drugs according to the utility model;

[0018] Figure 4 The utility model is a schematic diagram of the overall structure of the heat preservation mechanism of a reaction kettle for producing polypeptide drugs.

[0019] In the figure: 1. Reactor shell; 2. Upper cover; 3. Fixing ring; 4. Fixing hole; 5. Fixing bolt; 6. External protective shell; 7. Insulation mechanism; 8. Stirring and cleaning structure; 9. Feed inlet; 10. Discharge outlet; 11. Support legs; 12. Rotating motor; 13. Connecting rod; 14. Rectangular plate; 15. Scraper No. 1; 16. Rectangular groove; 17. Stabilizing rod; 18. Scraper No. 2; 19. Outer ring; 20. Insulation ring; 21. Fitting ring DETAILED DESCRIPTION

[0020] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific implementation methods.

[0021] In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front end", "rear end", "two ends", "one end", "the other end" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0022] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "provided with", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0023] See also Figure 1-4 , the utility model provides a technical solution:

[0024] A reactor for producing polypeptide drugs comprises a reactor shell 1, an upper cover 2 is fixedly connected to the upper end of the reactor shell 1, a fixing ring 3 is inserted and fixedly connected to the lower part of the upper cover 2 and the upper part of the reactor shell 1, a plurality of fixing holes 4 are opened on the two fixing rings 3, fixing bolts 5 are inserted and fixed between the plurality of fixing holes 4 on the two fixing rings 3, an external protective shell 6 is fixedly connected to the outer surface of the reactor shell 1, a heat preservation mechanism 7 is sleeved on the outer end of the external protective shell 6, a stirring and cleaning structure 8 is fixedly connected to the middle part of the upper end of the upper cover 2, a plurality of feeding ports 9 are fixedly connected to the left part of the upper end and the right part of the upper end of the upper cover 2, a discharge port 10 is fixedly connected to the middle part of the lower end of the reactor shell 1, and a plurality of supporting legs 11 are arranged in a circular array at the lower end of the reactor shell 1.

[0025] In this embodiment, the insulation mechanism 7 includes an outer ring 19, the inner wall of the outer ring 19 is fixedly connected to an insulation ring 20, the inner wall of the insulation ring 20 is fixedly connected to a fitting ring 21, the stirring and cleaning structure 8 is in contact with the inner wall of the reactor shell 1 but not fixed, the inside of the external protective shell 6 and the reactor shell 1 are in a vacuum state, the outer ring 19 is made of nylon, the insulation ring 20 is insulation foam cotton, and the fitting ring 21 is elastic. By setting the external protective shell 6 and the reactor shell 1 to a vacuum state, the internal heat dissipation can be slowed down, and the insulation ring 20 made of insulation cotton material is provided on the insulation mechanism 7, which can be isolated from the outside and reduce heat diffusion. The internal fitting ring 21 is elastic and can be fitted to the outside of the external protective shell 6.

[0026] In this embodiment, the stirring and cleaning structure 8 includes a rotating motor 12, and a connecting rod 13 is fixedly connected to the output end of the rotating motor 12. A rectangular plate 14 is fixedly connected to the left end and the right end of the outer surface of the connecting rod 13. The ends of the two rectangular plates 14 that are not in contact with the connecting rod 13 are fixedly connected to a scraper No. 15. Several groups of rectangular grooves 16 are opened on the two rectangular plates 14. A stabilizing rod 17 is fixedly connected between the upper and lower parts of the two rectangular plates 14. A scraper No. 2 18 is fixedly connected to the lower ends of the two rectangular plates 14. The scraper No. 15 is a triangular prism structure, the scraper No. 2 18 is an arc plate structure, and the stabilizing rod 17 is an arc structure. The scraper No. 15 and the scraper No. 2 18 are both in contact with the inner wall of the reactor shell 1 but are not fixed. The rotating motor 12 is fixedly connected to the upper cover 2. By opening the rectangular grooves 16 on the rectangular plates 14, the resistance can be reduced during stirring, and the stabilizing rod 17 can increase the connection between the two rectangular plates 14.

[0027] It should be noted that the utility model is a reactor for producing polypeptide drugs. During use, first, the raw materials are poured into the reactor shell 1 from the feed port 9, and then the pressure and temperature are adjusted to drive the raw materials inside to react quickly. Then, the stirring and cleaning structure 8 is used. The rotating motor 12 on the stirring and cleaning structure 8 drives the connecting rod 13. The connecting rod 13 is fixedly connected to a rectangular plate 14 with a rectangular groove 16, which can stir and mix the raw materials inside the reactor shell 1, and the scraper No. 15 and the scraper No. 2 18 fixedly connected to the rectangular plate 14 can scrape the inner wall of the reactor shell 1, which is convenient for Later, the inner wall of the reactor shell 1 is cleaned. The stabilizing rod 17 fixedly connected to the two rectangular plates 14 can increase the connection between the two rectangular plates 14. When in use, the interior of the external protective shell 6 is in a vacuum state, which can slow down the heat dissipated by the reactor shell 1 and save energy. At the same time, there is an insulation ring 20 made of insulation cotton material on the externally wrapped insulation mechanism 7, which can isolate the reactor shell 1 from the outside and further reduce the heat dissipation. The outer ring 19 is made of nylon, which can increase the wear resistance of the overall insulation mechanism 7, and the inside is an elastic fitting ring 21, which can fit the external protective shell 6.

[0028] The above shows and describes the basic principle and main features of the utility model and the advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only for explaining the principle of the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection claimed by the utility model is defined by the attached claims and their equivalents.

Claims

1. A reactor for producing polypeptide drugs, comprising a reactor shell (1), characterized in that: The upper end of the reactor shell (1) is fixedly connected with an upper cover (2), the lower part of the upper cover (2) and the upper part of the reactor shell (1) are both interspersed and fixedly connected with a fixing ring (3), the two fixing rings (3) are each provided with a plurality of fixing holes (4), and fixing bolts (5) are interspersed and fixed between the plurality of fixing holes (4) on the two fixing rings (3), the outer surface of the reactor shell (1) is fixedly connected with an external protective shell (6), the outer end of the external protective shell (6) is sleeved with a heat preservation mechanism (7), the middle part of the upper end of the upper cover (2) is fixedly connected with a stirring and cleaning structure (8), the left part of the upper end and the right part of the upper end of the upper cover (2) are both fixedly connected with a plurality of feeding ports (9), the middle part of the lower end of the reactor shell (1) is fixedly connected with a discharging port (10), and the lower end of the reactor shell (1) is provided with a plurality of supporting legs (11) in a circular array; The heat-insulating mechanism (7) comprises an outer ring (19), the inner wall of the outer ring (19) is fixedly connected to a heat-insulating ring (20), and the inner wall of the heat-insulating ring (20) is fixedly connected to a fitting ring (21).

2. A reaction kettle for producing polypeptide drugs according to claim 1, characterized in that: The stirring and cleaning structure (8) is in contact with the inner wall of the reactor shell (1) but is not fixed thereto, and a vacuum state is maintained between the inside of the outer protective shell (6) and the reactor shell (1).

3. A reaction vessel for producing polypeptide drugs according to claim 1, characterized in that: The outer ring (19) is made of nylon, the heat-insulating ring (20) is heat-insulating foam cotton, and the fitting ring (21) is elastic.

4. A reaction vessel for producing polypeptide drugs according to claim 1, characterized in that: The stirring cleaning structure (8) comprises a rotating motor (12), the output end of the rotating motor (12) is fixedly connected to a connecting rod (13), the left end and the right end of the outer surface of the connecting rod (13) are fixedly connected to rectangular plates (14), the ends of the two rectangular plates (14) that are not in contact with the connecting rod (13) are fixedly connected to a first scraper (15), the two rectangular plates (14) are provided with a plurality of groups of rectangular grooves (16), the upper and lower parts of the two rectangular plates (14) are fixedly connected to a stabilizing rod (17), and the lower ends of the two rectangular plates (14) are fixedly connected to a second scraper (18).

5. A reaction vessel for producing polypeptide drugs according to claim 4, characterized in that: The first scraper (15) is a triangular prism structure, the second scraper (18) is a circular arc plate structure, and the stabilizing rod (17) is a circular arc structure.

6. A reaction vessel for producing polypeptide drugs according to claim 4, characterized in that: The first scraper (15) and the second scraper (18) are both in contact with the inner wall of the reactor shell (1) but are not fixed, and the rotating motor (12) is fixedly connected to the upper cover (2).

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