Analysis and detection device for drug carrier

Abstract

The utility model discloses an analysis and detection device for a drug carrier, and relates to the technical field of drug carrier analysis and detection. The dialysis device comprises a barrel body and a cover plate located at the upper end of the barrel body, a dialysis cavity is formed in the upper end of the barrel body, and a dialysis assembly and a sampling assembly are arranged in the dialysis cavity; a plurality of first electric push rods are arranged on the side portion of the can body, pressing plates are arranged at the output ends of the first electric push rods, a plurality of side plates are arranged on the side portion of the cover plate, clamping grooves are formed in the side portions of the side plates, limiting grooves are formed in the upper ends of the side plates, and the pressing plates are clamped in the limiting grooves. The lower end of the cover plate is rotatably matched with a first column, and the lower portion of the first column is elastically matched with a second column. According to the garbage can, the pressing plate is matched with the clamping groove and the limiting groove, so that the first electric push rod is conveniently controlled to stretch out and draw back to limit or release limiting of the side plate, and the convenience of mounting and dismounting of the cover plate is improved; the first laser transmitter and the first laser collector can be conveniently inserted into a dialysis bag located in the dialysis assembly through the stretching-in rod.

Description

Technical Field

[0001] The utility model belongs to the field of drug carrier analysis and detection, and specifically relates to an analysis and detection device for drug carriers. Background Art

[0002] Drug carrier refers to a system that can change the way drugs enter the human body and their distribution in the body, control the release rate of drugs and deliver drugs to targeted organs. Drug carrier materials play a very important role in the research of controlled-release preparations. Since the 1960s, the research on controlled-release drug systems has attracted widespread attention. Controlled-release drug systems can improve the utilization, safety and effectiveness of drugs, thereby reducing the frequency of drug administration, and therefore have attracted attention.

[0003] A Chinese patent with publication number CN218121763U discloses a stimulus-responsive anticancer drug carrier effect analysis and detection device, which relates to the technical field of drug carrier effect analysis and detection, and specifically includes a detector housing, an inner top wall of an upper cover is provided with a servo motor, one end of an output shaft of the servo motor is provided with a first crown gear, an inner side wall of the upper cover is provided with an electric slip ring through a connecting rod, a laser emitter and a laser collector are provided on the inner top wall of the first crown gear, a dialysis bucket is provided on the inner side wall of a support frame, a first stirring blade is provided on the outer surface of the dialysis bucket, a second motor is provided on the inner side wall of the detector housing, a second stirring blade is provided on the outer surface of the output shaft of the second motor, and a telescopic suction tube is provided at one end of the telescopic rod of the electric telescopic rod through a connecting block. The device has the beneficial effects of facilitating real-time monitoring of drug concentration inside and outside the dialysis bag, accelerating the dialysis process and facilitating sampling of the dialysis medium.

[0004] However, during use of the stimulus-responsive anticancer drug carrier effect analysis detection device disclosed in the application, since the upper cover is hinged on the upper surface of the detector housing, it is difficult to transfer the laser emitter and the laser collector into the dialysis bag in the dialysis barrel when the upper cover is closed to ensure that the first crown gear and the second crown gear are engaged. Otherwise, there is a risk that the laser emitter and the laser collector will collide with the dialysis barrel and break. The laser emitter and the laser collector are placed outside the dialysis bag, which is likely to affect the accuracy of their monitoring of the transmittance of the solution inside the dialysis bag. Utility Model Content

[0005] The technical problem to be solved by the utility model is to overcome the deficiencies of the prior art and provide an analysis and detection device for a drug carrier.

[0006] In order to solve the above technical problems, the basic concept of the technical solution adopted by the utility model is:

[0007] An analysis and detection device for a drug carrier comprises a barrel body and a cover plate located at the upper end of the barrel body, wherein a dialysis cavity is arranged at the upper end of the barrel body, and a dialysis component and a sampling component are arranged in the dialysis cavity;

[0008] A plurality of first electric push rods are installed on the side of the barrel body, a pressure plate is installed on the output end of the first electric push rod, a plurality of side plates are provided on the side of the cover plate, a clamping groove corresponding to the output shaft of the first electric push rod is provided on the side of the side plate, and a limiting groove connected to the clamping groove is provided on the upper end, the clamping groove vertically penetrates the side plate, and the pressure plate is clamped in the limiting groove;

[0009] The lower end of the cover plate is rotatably engaged with the first column, and the lower part of the first column is elastically engaged with the second column, the first column and the second column are both located in the dialysis cavity, the lower end of the second column is provided with a slot corresponding to the dialysis component, the upper end of the inner wall of the slot is provided with two extension rods, the lower parts of the two extension rods are respectively provided with the first laser emitter and the first laser collector, the first laser emitter and the first laser collector are both located in the dialysis component, and the side part of the inner wall of the dialysis cavity is provided with multiple second laser emitters and multiple second laser collectors.

[0010] Optionally, a circular hole is provided at the lower end of the cover plate, a bearing is installed on the circumference of the inner wall of the circular hole, a rotating column corresponding to the bearing is installed at the upper end of the first column, and the bearing is installed on the circumference of the rotating column. The bearing reduces the friction between the first column and the cover plate when it rotates.

[0011] Optionally, a receiving groove is provided at the upper end of the second column, a plurality of sliding grooves are provided on the side of the receiving groove, the lower part of the first column slides in the receiving groove, a slider is provided on the side of the first column and slides in the sliding groove, a receiving groove is provided at the lower end of the first column, a spring is provided between the upper end of the inner wall of the receiving groove and the lower end of the inner wall of the receiving groove, and the second column maintains the compression of the dialysis component through the spring.

[0012] Optionally, the lower end of the cover plate is rotatably engaged with an inner gear ring and is provided with a ring plate located on the circumferential side of the inner gear ring, the inner gear ring is located on the circumferential side of the second cylinder, the circumferential side of the inner wall of the ring plate is provided with an annular groove corresponding to the inner gear ring, the circumferential side of the inner gear ring is located in the annular groove, a plurality of extension rods are installed at the lower end of the inner gear ring, the ring plate is located on the circumferential side of the plurality of extension rods, a stirring blade is installed at the lower end of the extension rod, the stirring blade rotatably engages in the dialysis chamber, a first motor is installed at the upper end of the cover plate, a gear rotatably engaged with the lower end of the cover plate is installed at the output end of the first motor, the gear is meshed with the inner wall side of the inner gear ring, and the gear is driven to rotate by the operation of the first motor, thereby driving the inner gear ring, the extension rods and the stirring blade to rotate, so that the stirring blade stirs the dialysis medium in the dialysis chamber.

[0013] Optionally, the dialysis assembly includes a second motor installed at the lower end of the barrel body, a dialysis barrel rotatably engaged in the dialysis cavity is installed at the output end of the second motor, the upper part of the dialysis barrel is clamped in the slot, the first laser emitter and the first laser collector are both located in the dialysis barrel, the side of the dialysis barrel is provided with a plurality of side ports and arc-shaped leaves, a filter is installed in the side port, the dialysis barrel and the arc-shaped leaves and the filter are driven to rotate by the operation of the second motor, thereby driving the dialysis bag and the first column and the second column to rotate.

[0014] Optionally, the sampling assembly includes a second electric push rod installed on the side of the barrel body, and the output end of the second electric push rod is provided with a suction nozzle that slides in the dialysis chamber. A hose is connected to the side of the suction nozzle. The distance between the suction nozzle and the dialysis barrel is adjusted by telescopic adjustment of the second electric push rod, thereby facilitating sampling of dialysis media at a specified distance.

[0015] After adopting the above technical solution, the utility model has the following beneficial effects compared with the prior art. Of course, any product implementing the utility model does not necessarily need to achieve all the advantages described below at the same time:

[0016] By cooperating with the pressing plate, the card slot and the limit slot, it is convenient to control the extension and retraction of the first electric push rod to limit or release the limit on the side plate, thereby improving the convenience of installing and removing the cover plate. By vertically installing the cover plate on the barrel body, it is convenient to insert the first laser emitter and the first laser collector into the dialysis bag in the dialysis assembly by using the insertion rod, while reducing the restriction on the insertion distance of the first laser emitter and the first laser collector, thereby ensuring the accuracy of the first laser emitter and the first laser collector in monitoring the transmittance of the solution inside the dialysis bag. The second column elastically slides in cooperation with the pressing plate to press down the cover plate, so that the second column uses the elastic force to press the dialysis assembly and the bag opening of the dialysis bag.

[0017] The specific implementation of the utility model is further described in detail below with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The drawings described below are only some embodiments. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0019] In the figure:

[0020] Figure 1 This is a schematic diagram of the three-dimensional structure of an embodiment of the utility model;

[0021] Figure 2 This is a schematic cross-sectional structure diagram of an embodiment of the utility model;

[0022] Figure 3 for Figure 2 Schematic diagram of the structure at A in the middle;

[0023] Figure 4 for Figure 2 Schematic diagram of the structure at point B in the middle.

[0024] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0025] Barrel body 1, dialysis chamber 101, base 102, second motor 2, dialysis barrel 201, side port 202, filter screen 203, arc leaf 204, cover plate 3, circular hole 301, side plate 302, slot 303, limit slot 304, positioning insert 305, ring plate 306, ring groove 307, sealing ring 308, first electric push rod 4, pressure plate 401, first motor 5, gear 501, inner gear ring 6, extension rod 6 01, stirring blade 602, first column 7, receiving groove 701, rotating column 702, slider 703, second column 8, receiving groove 801, slide groove 802, slot 803, sealing gasket 804, bearing 9, spring 10, first laser emitter 11, second laser emitter 1101, first laser collector 12, second laser collector 1201, second electric push rod 13, suction nozzle 14, hose 1401.

[0026] It should be noted that these drawings and textual descriptions are not intended to limit the conceptual scope of the present invention in any way, but rather to illustrate the concept of the present invention for those skilled in the art by referring to specific embodiments. DETAILED DESCRIPTION

[0027] The utility model will now be described in further detail with reference to the accompanying drawings.

[0028] See also Figure 1-4 As shown, in this embodiment, a drug carrier analysis and detection device is provided, including a barrel body 1, a cover plate 3 located at the upper end of the barrel body 1, a dialysis chamber 101 is provided at the upper end of the barrel body 1, a dialysis assembly and a sampling assembly are provided in the dialysis chamber 101, a positioning insert 305 and a sealing ring 308 are installed at the lower end of the cover plate 3, the sealing ring 308 is located at the peripheral side of the positioning insert 305, the sealing ring 308 is located between the cover plate 3 and the barrel body 1, the sealing ring 308 is used to improve the sealing performance of the connection between the cover plate 3 and the barrel body 1, the positioning insert 305 is clamped in the dialysis chamber 101 and fits with the inner wall thereof, and the positioning insert 305 is used to facilitate the positioning and placement of the cover plate 3;

[0029] A plurality of first electric push rods 4 are installed on the side of the barrel body 1, a pressing plate 401 is installed on the output end of the first electric push rod 4, a plurality of side plates 302 are installed on the side of the cover plate 3, a clamping groove 303 corresponding to the output shaft of the first electric push rod 4 is provided on the side of the side plate 302, and a limiting groove 304 connected to the clamping groove 303 is provided on the upper end, the clamping groove 303 vertically penetrates the side plate 302, and the pressing plate 401 is clamped in the limiting groove 304;

[0030] The lower end of the cover plate 3 is rotatably engaged with the first column 7, and the lower part of the first column 7 is elastically engaged with the second column 8. The first column 7 and the second column 8 are both located in the dialysis chamber 101. The lower end of the second column 8 is provided with a slot 803 corresponding to the dialysis component. The upper end of the inner wall of the slot 803 is provided with a sealing gasket 804 and two insertion rods. The insertion rods vertically penetrate the sealing gasket 804. The sealing gasket 804 is used to improve the sealing and friction of the connection between the dialysis component and the second column 8. The lower parts of the two insertion rods are respectively provided with a first laser emitter 11 and a first laser collector 12. The first laser emitter 11 and the first laser collector 12 are both located in the dialysis component. The side of the inner wall of the dialysis chamber 101 is provided with a plurality of second laser emitters 1101 and a plurality of second laser collectors 1201.

[0031] The application of one aspect of this embodiment is as follows: when in use, a certain amount of pigment is added to the inside of the dialysis bag, and then the dialysis bag is placed in the dialysis assembly, and then the bag mouth of the dialysis bag is opened at the upper part of the dialysis assembly, and the dialysis bag is sleeved on the outside of the dialysis assembly. At this time, the first electric push rod 4 is controlled to extend and push the pressure plate 401 to move upward, and the cover plate 3 is first placed above the barrel body 1, and the side plate 302 is misaligned with the pressure plate 401, and then the cover plate 3 is covered on the barrel body 1, so that the slot 803 of the second column 8 is sleeved above the dialysis assembly, and the first laser emitter 11 and the first laser collector 12 are extended into the dialysis bag by using the insertion rod, and then the cover plate 3 is rotated to drive the side plate 302 to rotate synchronously, so that the side plate 302 is clamped in the input of the first electric push rod 4 through the card slot 303. The first electric push rod 4 is controlled to contract and drive the pressure plate 401 to be inserted into the limiting groove 304, and the cover plate 3 is driven to be pressed on the barrel body 1 through the side plate 302. During this process, the second column 8 is pressed on the dialysis component by the elastic force, and the bag mouth of the dialysis bag is clamped and fixed by the second column 8 and the dialysis component. Then, the dialysis component is controlled to rotate the dialysis bag, and the first laser emitter 11 and the first laser collector 12 are used to monitor the transmittance of the solution inside the dialysis bag in real time. The second laser emitter 1101 and the second laser collector 1201 are used to monitor the transmittance of the dialysis medium in the dialysis cavity 101. Finally, the sampling component is controlled to sample the dialysis medium in the dialysis cavity 101.

[0032] A circular hole 301 is provided at the lower end of the cover plate 3 of the present embodiment, and a bearing 9 is installed on the circumferential side of the inner wall of the circular hole 301. A rotating column 702 corresponding to the bearing 9 is installed at the upper end of the first column 7. The bearing 9 is installed on the circumferential side of the rotating column 702. The bearing 9 reduces the friction between the first column 7 and the cover plate 3 when the first column 7 rotates, thereby facilitating the dialysis assembly to drive the second column 8 and the first column 7 to rotate.

[0033] In this embodiment, a receiving groove 801 is provided at the upper end of the second column 8, and a plurality of slide grooves 802 are provided on the side of the receiving groove 801. The lower part of the first column 7 is slidably fitted in the receiving groove 801, and a slider 703 is provided on the side of the first column 7 to slide in the slide groove 802. A receiving groove 701 is provided at the lower end of the first column 7, and a spring 10 is provided between the upper end of the inner wall of the receiving groove 701 and the lower end of the inner wall of the receiving groove 801. The spring 10 is used to keep the second column 8 from squeezing the dialysis assembly, thereby reducing the probability of the solution in the dialysis bag flowing from the bag mouth into the dialysis cavity 101.

[0034] The lower end of the cover plate 3 of this embodiment is rotatably matched with the inner gear ring 6, and is provided with a ring plate 306 located on the peripheral side of the inner gear ring 6. The positioning insert 305 is located on the peripheral side of the ring plate 306. The inner gear ring 6 is located on the peripheral side of the second column 8. The inner wall of the ring plate 306 is provided with a ring groove 307 corresponding to the inner gear ring 6. The peripheral side of the inner gear ring 6 is located in the ring groove 307. The ring groove 307 improves the stability of the inner gear ring 6 during rotation. A plurality of extension rods 601 are installed at the lower end of the inner gear ring 6. The ring plate 306 is located on the peripheral side of the plurality of extension rods 601. On the other hand, a stirring blade 602 is installed at the lower end of the extension rod 601, and the stirring blade 602 is rotatably fitted in the dialysis chamber 101. A first motor 5 is installed at the upper end of the cover plate 3, and a gear 501 rotatably fitted in the lower end of the cover plate 3 is installed at the output end of the first motor 5. The gear 501 is meshed with the inner wall side of the inner gear ring 6. The gear 501 is driven to rotate by the operation of the first motor 5, thereby driving the inner gear ring 6, the extension rod 601 and the stirring blade 602 to rotate, so that the stirring blade 602 stirs the dialysis medium in the dialysis chamber 101.

[0035] The dialysis assembly of this embodiment includes a second motor 2 installed at the lower end of the barrel body 1. A base 102 is installed at the lower end of the barrel body 1. The base 102 is located on the circumferential side of the second motor 2. The base 102 is a truncated cone structure. The stability of the barrel body 1 is improved by the base 102. A dialysis barrel 201 rotatably fitted in the dialysis cavity 101 is installed at the output end of the second motor 2. The upper part of the dialysis barrel 201 is clamped in the slot 803. The first laser emitter 11 and the first laser collector 12 are both located in the dialysis barrel 201. The side of the dialysis barrel 201 is provided with a plurality of side ports 202 and arc leaves 204. A filter screen 203 is installed in the side port 202. The dialysis barrel 201, the arc leaves 204 and the filter screen 203 are driven to rotate by the operation of the second motor 2, thereby driving the dialysis bag and the first column 7 and the second column 8 to rotate.

[0036] The sampling assembly of this embodiment includes a second electric push rod 13 installed on the side of the barrel body 1, and a suction nozzle 14 slidingly fitted in the dialysis chamber 101 is installed at the output end of the second electric push rod 13. A hose 1401 is connected to the side of the suction nozzle 14. One end of the hose 1401 passes through the outside of the barrel body 1 and is externally connected to a water pump and an electronic flow meter. The distance between the suction nozzle 14 and the dialysis barrel 201 is adjusted by telescopic adjustment of the second electric push rod 13, so as to facilitate sampling of the dialysis medium at a specified distance. At the same time, when the second electric push rod 13 is fully retracted, the probability of the suction nozzle 14 obstructing the rotation of the stirring blade 602 is reduced.

[0037] The present invention is not limited to the above-mentioned implementation modes. Anyone should be aware of the structural changes made under the inspiration of the present invention. Any technical solution that is the same or similar to the present invention falls within the protection scope of the present invention. The technology, shape, and structure that are not described in detail in the present invention are all known technologies.

Claims

1. An analytical detection device for a drug carrier, characterized in that: include: A barrel body (1), and a cover plate (3) located at the upper end of the barrel body (1); a dialysis cavity (101) is provided at the upper end of the barrel body (1); a dialysis component and a sampling component are provided in the dialysis cavity (101); A plurality of first electric push rods (4) are installed on the side of the barrel body (1), a pressure plate (401) is installed on the output end of the first electric push rod (4), a plurality of side plates (302) are installed on the side of the cover plate (3), a clamping groove (303) is provided on the side of the side plate (302), and a limiting groove (304) is provided on the upper end, and the pressure plate (401) is clamped in the limiting groove (304); The lower end of the cover plate (3) is rotatably engaged with the first column (7), the lower part of the first column (7) is elastically engaged with the second column (8), the lower end of the second column (8) is provided with a slot (803) corresponding to the dialysis component, the upper end of the inner wall of the slot (803) is provided with two insertion rods, and the lower parts of the two insertion rods are respectively provided with a first laser emitter (11) and a first laser collector (12).

2. The drug carrier analysis and detection device according to claim 1, characterized in that: A circular hole (301) is provided at the lower end of the cover plate (3), a bearing (9) is installed on the inner wall of the circular hole (301), and a rotating column (702) corresponding to the bearing (9) is installed at the upper end of the first column (7).

3. The drug carrier analysis and detection device according to claim 2, characterized in that: The upper end of the second column (8) is provided with a receiving groove (801), and the side of the receiving groove (801) is provided with a plurality of sliding grooves (802). The lower part of the first column (7) is slidably fitted in the receiving groove (801), and the side of the first column (7) is provided with a sliding block (703) slidably fitted in the sliding groove (802). The lower end of the first column (7) is provided with a receiving groove (701), and a spring (10) is provided between the upper end of the inner wall of the receiving groove (701) and the lower end of the inner wall of the receiving groove (801).

4. The drug carrier analysis and detection device according to claim 1, characterized in that: The lower end of the cover plate (3) is rotatably matched with an inner gear ring (6), and is provided with an annular plate (306) located on the circumferential side of the inner gear ring (6); an annular groove (307) corresponding to the inner gear ring (6) is provided on the circumferential side of the inner wall of the annular plate (306); a plurality of extension rods (601) are provided at the lower end of the inner gear ring (6); stirring blades (602) are provided at the lower end of the extension rods (601); a first motor (5) is provided at the upper end of the cover plate (3); a gear (501) rotatably matched with the lower end of the cover plate (3) is provided at the output end of the first motor (5); the gear (501) is meshed with the inner wall side of the inner gear ring (6).

5. The drug carrier analysis and detection device according to claim 1, characterized in that: The dialysis assembly comprises a second motor (2) mounted at the lower end of a barrel body (1); a dialysis barrel (201) rotatably engaged in a dialysis chamber (101) is mounted at the output end of the second motor (2); a plurality of side openings (202) and arc-shaped leaves (204) are arranged on the side of the dialysis barrel (201); and a filter (203) is arranged in the side opening (202).

6. The drug carrier analysis and detection device according to claim 1, characterized in that: The sampling assembly comprises a second electric push rod (13) mounted on the side of the barrel body (1), the output end of the second electric push rod (13) is equipped with a suction nozzle (14) which is slidably fitted in the dialysis chamber (101), and the side of the suction nozzle (14) is connected to a hose (1401).

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