Mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments

Abstract

The utility model discloses a mouse blood sampling device for pharmacodynamics and pharmacokinetics experiments, and relates to the technical field of animal medical treatment, the mouse blood sampling device comprises a bottom plate and a shell, one end of the shell is slidably connected with a baffle plate, the baffle plate is driven by a lifting assembly, one end of the lifting assembly is provided with a self-locking assembly, and the self-locking assembly is connected with the bottom plate. The self-locking assembly comprises a ratchet wheel, a pawl is arranged on one side of the ratchet wheel, the pawl is meshed with the ratchet wheel, a shifting block is fixedly installed at one end of the pawl, and a reset torsional spring is installed between the pawl and the lifting assembly. According to the mouse blood sampling device, through meshing of the pawl and the ratchet wheel in the self-locking assembly, the baffle is effectively self-locked, the phenomenon that blood sampling is interrupted after the baffle is opened when a pressing rod is touched by mistake in the blood sampling period of a mouse is prevented, and the stability of the mouse during blood sampling is further guaranteed.

Description

Technical Field

[0001] The utility model relates to the technical field of animal medical treatment, in particular to a mouse blood sampling device used for pharmacodynamics and pharmacokinetic experiments. Background Art

[0002] As an experimental animal, mice are often used as the first choice for medical and pharmaceutical experiments because of their small size, docility, large number, and easy reproduction. During the experiment, they often need to be fixed with a fixed sleeve and then injected into the tail vein for the convenience of the experiment;

[0003] The current mouse tail vein blood sampling fixing device, such as the mouse tail vein blood sampling fixing device described in the patent with announcement number CN217593135U, comprises: a base, a shell, a head limit block, a tail baffle and a pressure rod, the shell is arranged on the base, the shell and the base form a through cavity, the head limit block is slidably arranged inside one end of the shell, the other end of the shell has a slide groove adapted to the tail baffle, the slide groove is perpendicular to the base, the end of the tail baffle close to the base has a slot, one end of the pressure rod is hinged with the top of the shell, the pressure rod is provided with a slider that can slide along the length direction of the pressure rod, the slider is hinged with a connecting rod, the end of the connecting rod away from the slider is connected to the tail baffle, and a mouse tail fixing is arranged on the side of the base located at the tail baffle away from the shell. The utility model can quickly fix the mouse in the shell, and the two ends of the mouse tail can be fixed by using the tail baffle and the mouse tail fixing, so as to prevent the mouse tail from swinging when the mouse is taking blood from the tail vein.

[0004] In view of the above-mentioned related technologies, the applicant found that when the mouse tail vein blood sampling and fixing device is used, the mouse is fixed before blood sampling through the cooperation of the shell and the tail block under the action of the pressure rod, but due to a series of operations on the mouse, the awake mouse will feel very scared and nervous. Because the pressure rod itself is too long, if it accidentally touches the pressure rod during blood sampling, causing the tail baffle to rise, the frightened mouse is very likely to run out of the shell, interrupting the blood sampling and affecting the effect of the mouse during the blood sampling operation. To this end, we proposed a mouse blood sampling device for pharmacodynamics and pharmacokinetic experiments. Utility Model Content

[0005] The purpose of the utility model is to provide a device capable of self-locking a pressure rod, which can solve the problems raised in the above-mentioned background technology.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments, comprising a bottom plate and a shell, one end of the shell is slidably connected to a baffle, the baffle is driven by a lifting component, and one end of the lifting component is installed with a self-locking component;

[0007] The self-locking assembly comprises a ratchet, a pawl is arranged on one side of the ratchet, the pawl is meshed with the ratchet, a toggle block is fixedly mounted on one end of the pawl, and a reset torsion spring is mounted between the pawl and the lifting assembly.

[0008] By adopting the above technical solution, the lifting component can be effectively self-locked.

[0009] Preferably, an opening is provided in the middle of the bottom of the shell, a fixing piece is fixed to the end of the top of the base plate away from the shell, the baffle and the fixing piece are on the same horizontal line, a through groove for the baffle to slide is provided at one end of the shell, and a folding assembly is installed at the end of the lifting assembly away from the self-locking assembly.

[0010] By adopting the above technical solution, mice can be fixed.

[0011] Preferably, the lifting assembly includes a pressure rod, a fixing seat is fixedly installed on the top of the base plate near the baffle, the pressure rod and the fixing seat are connected by a fixed shaft, the outer wall of the pressure rod is slidably connected with a sliding sleeve, and the sliding sleeve and the baffle are connected by a movable rod.

[0012] By adopting the above technical solution, the baffle can be lifted and lowered.

[0013] Preferably, the folding assembly comprises an extension rod, the extension rod is rotatably connected to the pressure rod via a rotating shaft, and one end of the pressure rod is provided with a storage groove for storing the extension rod.

[0014] By adopting the above technical solution, the extension rod can be folded.

[0015] Preferably, a fixing sleeve is fixed on both sides of the outer wall of the pressure rod, the rotating shaft is inserted into the inside of the fixing sleeve, the outer wall of the rotating shaft is fixed with a first clamping block, the inner wall of the fixing sleeve is fixed with a second clamping block, and the second clamping block is clamped with the first clamping block.

[0016] By adopting the above technical solution, the extension rod can be fixed after being folded.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] Firstly, by providing a baffle and a self-locking component, the engagement between the pawl and the ratchet in the self-locking component enables the baffle to be effectively self-locked, thereby preventing the baffle from opening and interrupting blood collection when the pressure rod is accidentally touched during blood collection from mice, thereby further ensuring the stability of the mice during blood collection.

[0019] Secondly, by providing a baffle, a pressure rod and a folding assembly, the folding and fixation of the extension rod is achieved through the cooperation of the extension rod and the first clamping block in the folding assembly, so that after the baffle is closed, the total length of the pressure rod and the extension rod can be shortened, providing convenience for blood collection from mice. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the overall front view structure of the utility model;

[0021] Figure 2 This is a schematic diagram of the overall rear view structure of the utility model;

[0022] Figure 3 This is a schematic diagram of the connection structure between the lifting component and the self-locking component of the utility model;

[0023] Figure 4 This is a schematic diagram of the structure of the pressure rod and folding assembly of the utility model;

[0024] Figure 5 For this utility model Figure 4 Enlarged schematic diagram at point A in the middle.

[0025] In the figure: 1. bottom plate; 101. shell; 102. baffle; 1021. opening; 103. fixing piece; 104. through slot; 2. lifting assembly; 201. pressure rod; 2011. fixed shaft; 202. fixing seat; 203. sliding sleeve; 204. movable rod; 3. self-locking assembly; 301. ratchet; 302. pawl; 3021. toggle block; 303. reset torsion spring; 4. folding assembly; 401. extension rod; 4011. storage slot; 402. rotating shaft; 4021. first clamping block; 403. fixing sleeve; 4031. second clamping block. DETAILED DESCRIPTION

[0026] To facilitate the understanding of the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings. Several embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0027] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "page", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0028] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0029] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed", "provided with", etc. should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0030] The following is combined with Figure 1-5 The utility model is described in further detail.

[0031] See also Figure 1-Figure 3The figure shows a mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments, comprising a bottom plate 1 and a shell 101, one end of the shell 101 is slidably connected with a baffle 102, an opening 1021 is provided in the middle of the bottom of the shell 101, a fixing piece 103 is fixed at one end of the top of the bottom plate 1 away from the shell 101, the fixing piece 103 is a Velcro, the baffle 102 and the fixing piece 103 are at the same horizontal line, one end of the shell 101 is provided with a through slot 104 for the baffle 102 to slide, the baffle 102 is driven by a lifting component 2, and the lifting component 2 includes A pressure rod 201 is provided, and a fixing seat 202 is fixedly installed at a position near the baffle 102 on the top of the bottom plate 1. The pressure rod 201 and the fixing seat 202 are connected via a fixing shaft 2011. The fixing shaft 2011 and the pressure rod 201 are fixedly connected. The fixing shaft 2011 and the fixing seat 202 are rotatably connected. A sliding sleeve 203 is slidably connected to the outer wall of the pressure rod 201. The sliding sleeve 203 and the baffle 102 are connected via a movable rod 204. The movable rod 204 and the baffle 102 are fixedly connected. The movable rod 204 and the sliding sleeve 203 are rotatably connected.

[0032] A self-locking component 3 is installed at one end of the lifting component 2, and the self-locking component 3 includes a ratchet 301, a pawl 302 is provided on one side of the ratchet 301, the pawl 302 is meshed with the ratchet 301, a toggle block 3021 is fixedly installed at one end of the pawl 302, and the toggle block 3021 is controlled to drive the pawl 302 to rotate, so that the meshing state between the ratchet 301 and the pawl 302 can be adjusted, a reset torsion spring 303 is installed between the pawl 302 and the lifting component 2, the fixed shaft 2011 is fixedly connected to the ratchet 301, the pawl 302 is rotatably connected to the fixed seat 202, one end of the reset torsion spring 303 is fixedly connected to the pawl 302, and the other end of the reset torsion spring 303 is fixedly connected to the fixed seat 202;

[0033] When fixing the mouse, the pressure rod 201 is lifted, so that the sliding sleeve 203 drives the movable rod 204 and the baffle 102 to move upward horizontally under the limit of the through groove 104, and then the mouse is put into the shell 101, and then the pressure rod 201 is controlled to drive the baffle 102 to be lowered, and the tail of the mouse is exposed from the opening 1021, and after being fixed by the fixing member 103, venous blood is collected from the tail of the mouse. After the blood collection is completed, the mouse can be released;

[0034] During the lowering of the baffle 102, as the pressure rod 201 moves downward, the ratchet 301 is synchronously driven to rotate counterclockwise, and through the rotation of the ratchet 301, the pawl 302 in the meshing state is synchronously forced to swing to one side and reset again through the reset torsion spring 303. After the baffle 102 closes the shell 101, the engagement between the pawl 302 and the ratchet 301 in the self-locking component 3 makes the baffle 102 effectively self-locked, preventing the baffle 102 from accidentally touching the pressure rod 201 during blood collection from mice, preventing the blood collection from being interrupted after the baffle 102 is opened, and further ensuring the stability of the mouse during blood collection.

[0035] See also Figure 1-Figure 5 In the figure, a folding component 4 is installed at one end of the lifting component 2 away from the self-locking component 3, and the folding component 4 includes an extension rod 401, and the extension rod 401 is rotatably connected to the pressure rod 201 through a rotating shaft 402, and the rotating shaft 402 is fixedly connected to the extension rod 401. A storage groove 4011 for accommodating the extension rod 401 is opened at one end of the pressure rod 201, and fixed sleeves 403 are fixed on both sides of the outer wall of the pressure rod 201. The connection between the rotating shaft 402 and the fixed sleeve 403 is rotatably connected, and the rotating shaft 402 is inserted into the interior of the fixed sleeve 403. A first clamping block 4021 is fixed on the outer wall of the rotating shaft 402, and a second clamping block 4031 is fixed on the inner wall of the fixed sleeve 403. The second clamping block 4031 is clamped with the first clamping block 4021, and the first clamping block 4021 and the second clamping block 4031 are both made of elastic plastic.

[0036] When the extension rod 401 is stored, the extension rod 401 is pushed upward so that the extension rod 401 drives the rotating shaft 402 to rotate at one end of the pressure rod 201 until the extension rod 401 is rotated 180 degrees and stored in the storage groove 4011, thereby shortening the total length of the pressure rod 201 and the extension rod 401. During the period when the extension rod 401 drives the rotating shaft 402 to rotate, the first clamping block 4021 is synchronously driven to rotate in the fixing sleeve 403, and the rotation of the first clamping block 4021 causes plastic deformation between the first clamping block 4021 and the second clamping block 4031 until the extension rod 401 is stored in the storage groove 4011. The automatic fixation of the extension rod 401 after storage is achieved through the clamping connection between the first clamping block 4021 and the second clamping block 4031. Furthermore, by cooperating with the extension rod 401 and the first clamping block 4021 in the folding assembly 4, the extension rod 401 is folded and fixed, so that after the baffle 102 is closed, the total length of the pressure rod 201 and the extension rod 401 can be shortened, providing convenience for blood collection from mice.

[0037] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include"-"comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process-method-article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process-method-article or device.

[0038] In addition, the structures not introduced in the present invention do not involve the design points and improvement directions of the present invention, and all adopt the existing technology. The above content belongs to the technical cognition scope of the inventor. Since the technical content in this field is vast and too complicated, the above content of this application does not necessarily constitute the prior art.

[0039] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments, characterized in that: It comprises a base plate (1) and a shell (101), one end of the shell (101) being slidably connected to a baffle (102), the baffle (102) being driven by a lifting component (2), and one end of the lifting component (2) being equipped with a self-locking component (3); The self-locking assembly (3) comprises a ratchet (301), a pawl (302) being provided on one side of the ratchet (301), the pawl (302) being meshed with the ratchet (301), a toggle block (3021) being fixedly mounted on one end of the pawl (302), and a return torsion spring (303) being mounted between the pawl (302) and the lifting assembly (2).

2. A mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments according to claim 1, characterized in that: An opening (1021) is provided in the middle of the bottom of the shell (101); a fixing member (103) is fixedly provided at one end of the top of the bottom plate (1) away from the shell (101); the baffle (102) and the fixing member (103) are located at the same horizontal line; a through groove (104) for the baffle (102) to slide is provided at one end of the shell (101); and a folding member (4) is installed at one end of the lifting member (2) away from the self-locking member (3).

3. A mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments according to claim 1, characterized in that: The lifting assembly (2) comprises a pressure rod (201), a fixing seat (202) is fixedly installed at a position near the baffle (102) on the top of the base plate (1), the pressure rod (201) and the fixing seat (202) are connected via a fixed shaft (2011), a sliding sleeve (203) is slidably connected to the outer wall of the pressure rod (201), and the sliding sleeve (203) and the baffle (102) are connected via a movable rod (204).

4. A mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments according to claim 2, characterized in that: The folding assembly (4) comprises an extension rod (401), wherein the extension rod (401) is rotatably connected to the pressure rod (201) via a rotating shaft (402), and a storage groove (4011) for storing the extension rod (401) is provided at one end of the pressure rod (201).

5. A mouse blood sampling device for pharmacodynamic and pharmacokinetic experiments according to claim 4, characterized in that: A fixing sleeve (403) is fixedly provided on both sides of the outer wall of the pressure rod (201), the rotating shaft (402) is inserted into the interior of the fixing sleeve (403), a first clamping block (4021) is fixedly provided on the outer wall of the rotating shaft (402), and a second clamping block (4031) is fixedly provided on the inner wall of the fixing sleeve (403), and the second clamping block (4031) is clamped with the first clamping block (4021).

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