Slow-release antibacterial dressing
By designing the hydrophilic absorption material and the antibacterial layer of the hydrophilic absorption material and the antibacterial component in the wound dressing, the problem of the rapid release of antibacterial ingredients in the existing dressing is relieved, and the more persistent antibacterial effect and better trauma healing are achieved.
Patent Information
- Application Number
- CN202420164494.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-01-23
- Publication Date
- 2025-01-28
- Estimated Expiration
- 2034-01-23
AI Technical Summary
After existing wound dressings are exposed to the wound exudate, antibacterial ingredients will be released quickly, resulting in reduced antibacterial aging and may trigger allergic reactions and inflammation, affecting wound healing.
Design a mitter -release antibacterial dressing contains the dressing substrate, the absorption layer and the antibacterial layer. The antibacterial layer is composed of hydrophilic absorption materials and antibacterial ingredients. The antibacterial ingredients are covered by hydrophilic absorption materials, and the antibacterial ingredients are slowly released by absorbing trauma osmotic.
By slowly release the antibacterial ingredients, the resistance of antibacterial effect is extended, and allergies and inflammation caused by high concentration of antibacterial ingredients are avoided, and the healing of trauma is promoted.
Smart Images
Figure CN222399163U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to dressing technology, in particular to a slow-release antibacterial dressing. Background Art
[0002] Generally, wounds caused by skin injuries are usually treated with wound dressings. The wounds are covered with wound dressings to prevent pathogens in the external environment from directly contacting the wounds, thereby reducing the risk of bacterial infection of the wounds. Currently, wound dressings on the market have antibacterial effects. When the wounds are actually applied, the wound dressings can release antibacterial ingredients to the wound site to provide a bactericidal effect.
[0003] However, existing wound dressings still have some deficiencies. For example, most wound dressings are coated with an antibacterial film on the surface of the dressing absorption layer. Since the antibacterial film is composed of only antibacterial components, when the wound dressing is applied to the wound, the antibacterial film contacts the wound exudate and rapidly releases high-concentration antibacterial components. In addition to reducing the antibacterial timeliness of the antibacterial film, the high-concentration antibacterial components infiltrate the wound site and may cause allergic reactions, or even cause inflammation of the wound site, thereby reducing the effect of wound healing.
[0004] Therefore, how to develop dressings that slowly release antibacterial ingredients is a technical topic that many related industries are currently focusing on. Utility Model Content
[0005] In view of this, the purpose of the utility model is to provide a slow-release antibacterial dressing, which can slowly release antibacterial components by absorbing wound exudate when applied to the wound, thereby extending the durability of the antibacterial effect.
[0006] In order to achieve the above-mentioned purpose, the utility model provides a sustained-release antibacterial dressing, comprising a dressing base, an absorption layer and an antibacterial layer. The dressing base has an adhesive surface; the absorption layer is fixed on the adhesive surface of the dressing base; the antibacterial layer is arranged on the peripheral surface of the absorption layer, and the antibacterial layer contains a hydrophilic absorption material and an antibacterial component, and the antibacterial component is coated by the hydrophilic absorption material and distributed in the antibacterial layer.
[0007] In one embodiment, the antibacterial layer does not include an antibacterial surface composed of the antibacterial component.
[0008] In one embodiment, the antibacterial component includes one or a combination of polyhexamethylene hydrochloride (PHMB), chlorhexidine gluconate, and silver ions.
[0009] In one embodiment, the hydrophilic absorbent material comprises a hydrophilic polymer colloid (Hydrocolloid) or a hydrogel (Hydrogel), and the content of the antibacterial component accounts for 0.1wt% to 1wt% of the total weight of the antibacterial layer.
[0010] In one embodiment, the hydrophilic polymer colloid mixture includes styrene thermoplastic elastomer, a thickener and an absorbent material, the absorbent material includes one or a combination of the group consisting of pectin, gelatin or carboxymethyl cellulose, and the hydrogel includes one or a combination of the group consisting of polyethylhexyl acrylate-polyethylene glycol (poly-HEMA-PEG), polyglutamic acid, N-vinyl pyrrolidone, and polyethylene glycol.
[0011] In one embodiment, the absorbent layer comprises a liquid-absorbing layer adhered to the adhesive surface of the dressing base, and the liquid-absorbing layer contains a super absorbent polymer.
[0012] In one embodiment, the absorbent layer comprises a guide layer bonded to one side of the absorbent layer, the guide layer has a plurality of directional micropores therein, the antibacterial layer is attached to the outer peripheral surface of the guide layer without contacting the dressing base, and part of the hydrophilic absorbent material and / or the antibacterial component of the antibacterial layer penetrates into the micropores on the outer peripheral surface of the guide layer, and the plurality of micropores are used to attract the wound exudate penetrated by the antibacterial layer to the absorbent layer for absorption.
[0013] In one embodiment, a wound contact layer is further provided on the antibacterial layer, and the wound contact layer has a plurality of pores distributed thereon.
[0014] In one embodiment, the content of the antibacterial component released by the antibacterial layer after absorbing wound exudate within 4 hours is no more than 0.7 mg.
[0015] The effect of the utility model is that the antibacterial components of the antibacterial layer are coated by the hydrophilic absorbent material and distributed inside the antibacterial layer, and the hydrophilic absorbent material has a hydrophilic property and can be dissolved by liquid, whereby the antibacterial layer needs to absorb liquid to dissolve the hydrophilic absorbent material so that the antibacterial components inside the antibacterial layer can be released.
[0016] Therefore, when the sustained-release antibacterial dressing is actually applied to the wound site, the hydrophilic absorbent material can be dissolved by the wound exudate, so that the antibacterial components are slowly released from the antibacterial layer, so as to avoid the immediate release of high-concentration antibacterial components and cause allergies and inflammation in the wound site, and prolong the durability of the antibacterial effect, and can also help to provide the effect of accelerating wound healing. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 The figure is a schematic structural diagram of a sustained-release antibacterial dressing according to a preferred embodiment of the utility model.
[0018] Figure 2 The present invention is a flowchart of the steps of a method for manufacturing a sustained-release antibacterial dressing according to a preferred embodiment of the present invention.
[0019] Figure 3 This is a flow chart of a method for manufacturing a sustained-release antibacterial dressing according to a preferred embodiment of the present invention.
[0020] Description of reference numerals:
[0021] 100: Sustained-release antibacterial dressing
[0022] 10: Dressing base
[0023] 11: Adhesive surface
[0024] 20: Absorption layer
[0025] 21: Liquid absorption layer
[0026] 22: Diversion layer
[0027] 22a: Micropore
[0028] 221: Outer surface
[0029] 30: Antibacterial layer
[0030] 40: Wound contact layer
[0031] 41: Stoma
[0032] S1~S4: Steps DETAILED DESCRIPTION
[0033] In order to more clearly illustrate the present invention, a preferred embodiment is given below with detailed description in conjunction with the accompanying drawings. Figure 1 The utility model provides a sustained-release antibacterial dressing 100, which can slowly release antibacterial components by absorbing wound exudate when applied to a wound; in this embodiment, the structure of the sustained-release antibacterial dressing 100 basically includes a dressing base 10, an absorption layer 20, an antibacterial layer 30 and a wound contact layer 40.
[0034] The dressing base 10 is mainly used to load the absorption layer 20, the antibacterial layer 30 and the wound contact layer 40. In this embodiment, the dressing base 10 is made of a polyurethane (PU) film, which not only prevents foreign matter from invading and blocks external liquid from penetrating into the interior, but also can discharge body fluids or moisture applied to the human skin, that is, provides waterproof and breathable functions. One side of the dressing base 10 has an adhesive surface 11 for bonding the absorption layer 20.
[0035] The absorbent layer 20 is bonded to the adhesive surface 11 of the dressing substrate 10. In this embodiment, the absorbent layer 20 includes a liquid-absorbing layer 21 and a flow-guiding layer 22. The liquid-absorbing layer 21 and the flow-guiding layer 22 are stacked together, and the absorbent layer 20 is bonded to the adhesive surface 11 of the dressing substrate 10 by the liquid-absorbing layer 21. The liquid-absorbing layer 21 is made of paper fiber and contains a superabsorbent polymer. The liquid-absorbing layer 21 has a high-efficiency liquid-absorbing effect; the guide layer 22 is separated from the dressing substrate 10 and combined with one side of the liquid-absorbing layer 21, so that the liquid-absorbing layer 21 is located between the guide layer 22 and the dressing substrate 10, wherein the guide layer 22 is a non-woven fabric, and has a plurality of directional micropores 22a inside the guide layer 22, and the plurality of micropores 22a can guide liquid through capillary action, so as to attract the wound exudate infiltrated by the antibacterial layer 30 to the liquid-absorbing layer 21 for absorption.
[0036] In other embodiments, the structure and material type of the dressing base 10 and the absorption layer 20 can be adjusted arbitrarily according to product requirements. For example, the dressing base 10 is not limited to a polyurethane (PU) film, and it is not necessary to have waterproof and moisture permeability. It is sufficient as long as the dressing base 10 can provide support for the absorption layer 20, the antibacterial layer 30 and the wound contact layer 40. The absorption layer 20 is not limited to including the liquid absorption layer 21 and the guide layer 22, that is, the absorption layer 20 can choose to omit the guide layer 22 to form a single-layer structure with only the liquid absorption layer 21, or replace the material of the liquid absorption layer 21 and the material of the guide layer 22 with other types, as long as the function of absorbing liquid can be provided.
[0037] The antibacterial layer 30 is arranged on the peripheral surface of the absorption layer 20, and the antibacterial layer 30 contains a mixture of a hydrophilic absorbent material and an antibacterial component. Since the hydrophilic absorbent material has a certain adhesion ability, the antibacterial layer 30 is attached to the outer peripheral surface 221 of the guide layer 22 without contacting the dressing base 10, and part of the hydrophilic absorbent material or / and the antibacterial component of the antibacterial layer 30 penetrates into the micropores 22a of the outer peripheral surface 221 of the guide layer 22. It should be specially noted that the antibacterial layer 30 does not include an antibacterial surface composed of the antibacterial component, that is, the antibacterial component of the antibacterial layer 30 is covered by the hydrophilic absorbent material and distributed inside the antibacterial layer 30, and the hydrophilic absorbent material has a hydrophilic property and can absorb liquid and swell. The antibacterial layer 30 needs to absorb liquid to swell the hydrophilic absorbent material so that the antibacterial component inside the antibacterial layer 30 can be released.
[0038] Next, the types of the hydrophilic absorbent material and the antibacterial component described in this embodiment are described. The content of the hydrophilic absorbent material accounts for about 60-80wt% of the total weight of the antibacterial layer 30. The hydrophilic absorbent material includes a hydrophilic polymer colloid (Hydrocolloid) or a hydrogel (Hydrogel), wherein the hydrophilic polymer colloid mixture includes styrene which is a thermoplastic elastomer, a thickener and an absorbent material, the absorbent material includes one of the group consisting of pectin, gelatin or carboxymethyl cellulose or a combination thereof, and the hydrogel includes one of the group consisting of polyethylhexyl acrylate-polyethylene glycol (poly-HEMA-PEG), polyglutamic acid, N-vinyl pyrrolidone, and polyethylene glycol or a combination thereof.
[0039] The content of the antibacterial component accounts for 0.1wt% to 1wt% of the total weight of the antibacterial layer 30. In a preferred embodiment, the content of the antibacterial component accounts for 0.2wt% to 0.5wt% of the total weight of the antibacterial layer 30. The antibacterial component includes one or a combination of the group consisting of polyhexamethylene hydrochloride (PHMB), chlorhexidine gluconate, and silver ions. The type and content of the antibacterial component are designed to allow the antibacterial layer 30 to have antibacterial capabilities against a variety of microorganisms when releasing the antibacterial component.
[0040] The wound contact layer 40 is arranged on the antibacterial layer 30 and is used to contact the skin or wound part of the human body. The wound contact layer 40 is distributed with a plurality of pores 41, which can provide a breathable and comfortable fit effect. However, in other embodiments, the wound contact layer 40 can be omitted, and the sustained-release antibacterial dressing 100 only needs to basically have the structure of the dressing base 10, the absorption layer 20 and the antibacterial layer 30.
[0041] When the sustained-release antimicrobial dressing 100 is actually applied to a wound, the wound contact layer 40 is brought into contact with the wound site, so that the wound exudate can be absorbed by the antimicrobial layer 30 through the pores of the wound contact layer 40. At this time, the antimicrobial layer 30 absorbs the wound exudate through the hydrophilic absorbent material, so that the hydrophilic absorbent material is dissolved due to the wound exudate, thereby the antimicrobial components can be slowly released from the antimicrobial layer 30 to avoid immediate release of high-concentration antimicrobial components to cause allergies and inflammation at the wound site, thereby prolonging the durability of the antimicrobial effect.
[0042] See also Figure 2 and Figure 3 Another embodiment of the present invention provides a method for manufacturing the sustained-release antibacterial dressing 100 of the aforementioned embodiment, comprising the following steps:
[0043] Step S1, providing the absorption layer 20;
[0044] Step S2, mixing the hydrophilic absorbent material with the antibacterial component, wherein the antibacterial component is coated by the hydrophilic absorbent material to form an antibacterial adhesive, and the antibacterial component is distributed in the antibacterial adhesive.
[0045] Step S3, coating the antibacterial adhesive on the peripheral surface of the absorption layer 20, and curing to form the antibacterial layer 30. In the present embodiment, the antibacterial adhesive is coated on the peripheral surface 221 of the guide layer 22 of the absorption layer 20, so that the antibacterial layer 30 is cured and formed on the guide layer 22. The antibacterial adhesive can be coated by one of scraping, spraying and mesh coating, and the antibacterial adhesive can be cured by UV irradiation to form the antibacterial layer 30. However, the coating and curing methods of the antibacterial adhesive are not limited thereto.
[0046] Step S4, the absorbent layer 20 and the antibacterial layer 30 are rolled up, the liquid-absorbing layer 21 of the absorbent layer 20 is adhered to the dressing base 10, and the wound contact layer 40 is wrapped around the absorbent layer 20 and the antibacterial layer 30 and adhered to the dressing base 10, followed by stamping to obtain the sheet-like sustained-release antibacterial dressing 100, and finally the sustained-release antibacterial dressing 100 is sterilized.
[0047] Thus, the manufacturing method optimizes the process steps and is simple to operate, which can effectively improve the process efficiency for the industry to achieve mass production performance.
[0048] In addition, in order to fully understand the purpose, characteristics and technical effects of the present invention, this embodiment provides a characteristic analysis of the sustained-release antibacterial dressing 100. This experiment provides an experimental group and a control group to respectively explore the antibacterial release test of the sustained-release antibacterial dressing 100.
[0049] Test sample:
[0050] Experimental group: The sustained-release antibacterial dressing 100 comprises the absorbent layer 20 and the antibacterial layer 30, wherein the absorbent layer 20 is of the structure and material as in the aforementioned embodiment, and the antibacterial layer comprises the hydrophilic absorbent material and the antibacterial component as in the aforementioned embodiment, wherein the antibacterial component is coated by the hydrophilic absorbent material and distributed in the antibacterial layer 30, and in this experiment, the antibacterial component is polyhexamethylene hydrochloride (PHMB) with a concentration of 2000 ppm.
[0051] Control group: The existing antibacterial dressing basically includes a gel layer and an antibacterial layer (not shown in the figure). The detailed structure of the existing antibacterial dressing is briefly described. The gel layer is formed by solidification of hydrogel, and the antibacterial layer is coated on the surface of the gel layer. In this experiment, the antibacterial layer is composed of antibacterial components, wherein the antibacterial component is polyhexamethylene hydrochloride (PHMB) with a concentration of 2000ppm.
[0052] Test steps:
[0053] 1. Sample preparation: weigh the sample (W1) and cut it into 1x1cm size.
[0054] 2. Extraction: Place the cut sample in a beaker and add 40 times the weight of W1 of pure water (W2), place in a 37°C oven, and shake on a rocking shaker clockwise (100 rpm) for 24 hours.
[0055] 3. Filter. First use filter paper to filter out the insoluble matter, and then filter the filtrate using 0.45μm filter, which is the "extract".
[0056] 4. Quantification: The extract was entrusted to LC / MS for quantification of PHMB content.
[0057] Table 1. Release results of antibacterial components in the control group and the experimental group:
[0058]
[0059] No release was detected (Not detected, ND)
[0060] Detection limit = 0.2 mg
[0061] From the test results in Table 1 above, it can be found that the PHMB release amount of the experimental group and the control group was 1.0-1.2 mg during the release time of 1 hour, and the PHMB release amount of the experimental group was not detected, indicating that the PHMB release amount of the experimental group was lower than 0.2 mg and could not be detected; the PHMB release amount of the experimental group and the control group was 1.0-1.2 mg during the release time of 4 hours, and the PHMB release amount of the experimental group was 0.4-0.5 mg; the PHMB release amount of the experimental group and the control group was 1.0-1.2 mg during the release time of 24 hours.
[0062] The above-mentioned antibacterial release test confirmed that the control group maintained an antibacterial component release of 1.0 to 1.2 mg at each release time, indicating that the antibacterial layer of the control group would dissolve immediately when in contact with liquid and release a large amount of high-concentration antibacterial components. Because the antibacterial layer of the control group does not contain a hydrophilic absorbent material, and the antibacterial layer is coated on the surface of the gel layer, when the antibacterial layer of the control group contacts liquid, the antibacterial components in the antibacterial layer will immediately dissolve and be directly and completely released. Compared with the experimental group, the content of the antibacterial components released within 4 hours is no more than 0.7 mg, so as to slowly release the antibacterial components. When the experimental group is actually applied to the wound site, the hydrophilic absorbent material is dissolved due to the wound exudate, so that the antibacterial components can be slowly released from the antibacterial layer body 30, so as to avoid the immediate release of high-concentration antibacterial components and cause allergies and inflammation at the wound site, and further prolong the durability of the antibacterial effect, and can also help to provide an effect of accelerating wound healing.
[0063] The above description is only a preferred feasible embodiment of the present utility model. Any equivalent changes made by applying the specification and claims of the present utility model should be included in the scope of the claims of the present utility model.
Claims
1. A sustained-release antibacterial dressing, characterized in that: include: a dressing substrate having an adhesive surface; an absorbent layer fixed to the adhesive surface of the dressing base; and An antibacterial layer is arranged on the peripheral surface of the absorbent layer. The antibacterial layer contains a mixture of a hydrophilic absorbent material and an antibacterial component. The antibacterial component is covered by the hydrophilic absorbent material and distributed in the antibacterial layer.
2. The sustained-release antibacterial dressing according to claim 1, characterized in that: The antibacterial layer does not include an antibacterial surface composed of the antibacterial component.
3. The sustained-release antibacterial dressing according to claim 1, characterized in that: The content of the hydrophilic absorbent material is about 60wt% to 80wt% of the total weight of the antibacterial layer. The hydrophilic absorbent material comprises a hydrophilic polymer colloid or a hydrogel. The content of the antibacterial component is 0.1wt% to 1wt% of the total weight of the antibacterial layer.
4. The sustained-release antibacterial dressing according to claim 1, characterized in that: The absorbent layer body comprises a liquid-absorbing layer adhered to the adhesive surface of the dressing substrate, and the liquid-absorbing layer contains a super absorbent polymer.
5. The sustained-release antibacterial dressing according to claim 4, characterized in that: The absorbent layer comprises a guide layer bonded to one side of the liquid-absorbing layer, the guide layer has a plurality of directional micropores inside, the antibacterial layer is attached to the outer peripheral surface of the guide layer without contacting the dressing substrate, and part of the hydrophilic absorbent material and / or the antibacterial component of the antibacterial layer penetrates into the micropores on the outer peripheral surface of the guide layer, and the plurality of micropores are used to attract the wound exudate penetrated by the antibacterial layer to the liquid-absorbing layer for absorption.
6. The sustained-release antibacterial dressing according to claim 5, characterized in that: It also comprises a wound contact layer which is arranged on the antibacterial layer, and the wound contact layer is provided with a plurality of pores.
7. The sustained-release antibacterial dressing according to claim 1 or 2, characterized in that: The content of the antibacterial component released by the antibacterial layer after absorbing wound exudate within 4 hours is no more than 0.7 mg.