Nucleic acid extraction device capable of automatically opening and closing cover

Abstract

The utility model relates to a nucleic acid extraction device capable of automatically opening and closing a cover. The nucleic acid extraction device comprises a base, an adjusting piece fixed on the upper surface of the base, a heating module driven by the adjusting piece, an adjusting piece and a lifting piece which are arranged on one side of the heating module, and a magnetic sleeve assembly positioned above the heating module, the base comprises a bottom plate and a movable plate located on one side of the bottom plate, a plurality of spring hinges are arranged at the joint of the bottom plate and the movable plate for connection, and the heating module comprises a flat plate with a plurality of mounting holes, a plurality of heating blocks located in the mounting holes, a plurality of locking blocks for fixing the heating blocks and a fixing plate. A first supporting piece and a second supporting piece are installed on the two sides of the fixed plate correspondingly, pushing rollers are installed on the outer sides of the first supporting piece and the second supporting piece correspondingly, and the heating module is driven by the adjusting motor to move along the guide rails, so that the pushing rollers at the front end of the heating module conduct pushing and pressing operation on the movable plate. Meanwhile, the position of the magnetic sleeve assembly is automatically adjusted through the adjusting piece and the lifting piece, automatic operation is achieved, and the nucleic acid extraction efficiency is improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical machinery, and in particular to a nucleic acid extraction device with an automatic opening and closing cover. Background Art

[0002] Nucleic acid extractors are instruments that automatically extract nucleic acid from samples using matching nucleic acid extraction reagents. They are widely used in disease control centers, clinical disease diagnosis, and other fields. They use matching nucleic acid extraction reagents to complete nucleic acid extraction instruments. Currently, there are several defects and deficiencies in nucleic acid extractors on the market. Nucleic acid extractors cannot be integrated with the platform due to height and position issues, and their robotic arms cannot be inserted into the instrument to achieve automated operation. The movable cover of the shell that holds the nucleic acid extractor needs to be manually adjusted, which seriously affects the efficiency of nucleic acid extraction.

[0003] Therefore, it is necessary to develop a nucleic acid extraction device with an automatic opening and closing cover to solve the above problems. Utility Model Content

[0004] The utility model aims to provide a nucleic acid extraction device with high automation and high efficiency and automatic cover opening and closing.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a nucleic acid extraction device with automatic opening and closing cover, comprising a base, an adjusting member fixed to the upper surface of the base, a heating module driven by the adjusting member, an adjusting member and a lifting member installed on one side of the heating module, and a magnetic sleeve assembly located above the heating module; the base comprises a bottom plate and a movable plate located on one side of the bottom plate, a plurality of spring hinge connections are provided at the connection between the bottom plate and the movable plate, the heating module comprises a flat plate with a plurality of mounting holes, a plurality of heating blocks located in the mounting holes, a plurality of locking blocks and a fixing plate for fixing the heating blocks, a first support member and a second support member are respectively installed on both sides of the fixing plate, and pushing rollers are installed on the outer sides of the first support member and the second support member, and the pushing rollers comprise a first pushing roller and a second pushing roller, the first pushing roller is located at the front end of the first support member and the second support member, and the second pushing roller is located at the bottom of the first support member and the second support member.

[0006] Furthermore, the adjusting member includes an adjusting motor fixed to the upper surface of the base plate, a driving wheel installed below the adjusting motor, and a driven wheel installed on one side of the driving wheel. A synchronous belt is connected around the driving wheel and the driven wheel.

[0007] Furthermore, guide rails are installed on both sides of the synchronous belt, and the guide rails extend from one end of the base plate to the other end thereof.

[0008] Furthermore, sliding blocks are fixedly mounted on the lower surfaces of the first support member and the second support member, the sliding blocks are clamped with the guide rails, and an adapter is fixedly mounted on the inner side of the first support member, the adapter clamps the synchronous belt.

[0009] Furthermore, the adjustment member includes a mounting plate, an adjustment motor located on one side of the mounting plate, and a movable seat driven by the adjustment motor, the mounting plate is located between a pair of guide rails, the adjustment motor has an adjustment screw, the adjustment screw is located above the mounting plate, and the movable seat is sleeved with the adjustment screw.

[0010] Furthermore, the lifting member includes a support seat, a pair of lifting motors installed on one side of the support seat, and a pair of transmission belts driven by the lifting motors respectively. The lifting motor has a rotating shaft that passes through the support seat to drive the transmission belts to rotate.

[0011] Furthermore, the support seat is located between the pair of guide rails, the bottom of the support seat is fixedly connected to the upper surface of the movable seat, and the top of the support seat extends vertically upward.

[0012] Compared with the prior art, the beneficial effect of the utility model is that the utility model is a nucleic acid extraction instrument with automatic opening and closing cover, which has the characteristics of high automation and high efficiency. The motor is mobilized to drive the heating module to move along the guide rail, so that the pushing roller at the front end of the heating module pushes and presses the movable plate. At the same time, the position of the magnetic sleeve assembly is automatically adjusted through the adjustment part and the lifting part to realize automatic operation, thereby improving the extraction efficiency of nucleic acid. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative work, among which:

[0014] Figure 1 This is a three-dimensional structural schematic diagram of a nucleic acid extraction device with an automatic opening and closing cover according to the utility model;

[0015] Figure 2 for Figure 1 A schematic diagram of a partial structure of a nucleic acid extraction device with an automatic opening and closing cover;

[0016] Figure 3 for Figure 1 A schematic diagram of the structure of the actuating member of the nucleic acid extraction device with automatic opening and closing of the cover;

[0017] Figure 4 for Figure 1An exploded view of the local structure of the nucleic acid extraction device with automatic opening and closing cover shown;

[0018] Figure 5 for Figure 1 An exploded view of another part of the structure of the nucleic acid extraction device with automatic opening and closing cover;

[0019] Figure 6 for Figure 1 An exploded view of the adjustment member structure of the nucleic acid extraction device with automatic opening and closing cover;

[0020] Figure 7 for Figure 1 An exploded view of the lifting structure of the nucleic acid extraction device with automatic opening and closing cover;

[0021] Figure 8 for Figure 1 A schematic diagram of the structure of the magnetic sleeve assembly of the nucleic acid extraction device with automatic opening and closing cover is shown. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] Please see Figures 1 to 8 The utility model is a nucleic acid extraction device with an automatic opening and closing cover, which includes a base 1, an adjusting member 2 fixed to the upper surface of the base 1, a heating module 3 driven by the adjusting member 2, an adjusting member 4 and a lifting member 5 installed on one side of the heating module 3, and a magnetic sleeve assembly 6 located above the heating module 3.

[0024] Please see Figure 1 to Figure 2 The base 1 includes a bottom plate 11 and a movable plate 12 located on one side of the bottom plate 11. The bottom plate 11 is a rectangular plate body, and its lower surface is fixed to the surface of other equipment. The bottom plate 11 is in a horizontal state. The movable plate 12 is a rectangular plate body, and its width is the same as that of the bottom plate 11. A plurality of spring hinges 13 are provided at the connection between the bottom plate 11 and the movable plate 12, and the two sides of the spring hinges 13 are fixedly connected to the bottom plate 11 and the movable plate 12 respectively.

[0025] Please see Figures 1 to 3The adjusting member 2 includes a bracket 21, an adjusting motor 22 located above the bracket 21, a driven wheel 23 located on one side of the adjusting motor 22, and a synchronous belt 24 connected to the adjusting motor 22. Both ends of the bracket 21 are vertically fixed downward to the upper surface of the base plate 1, and a through hole is provided at the center thereof penetrating the upper and lower surfaces thereof. The adjusting motor 22 is vertically fixed to the upper surface of the bracket 21, and a driving wheel 221 is provided at the bottom thereof. The driving wheel 221 vertically penetrates the through hole downward and is placed below the bracket 21. A fixing seat 25 is provided at the bottom of the driven wheel 23, and the fixing seat 25 is fixed to the upper surface of the base plate 1. A fixing shaft 26 is installed inside the fixing seat, and the fixing shaft 26 is vertically connected to the driven wheel 23 upward. The driving wheel 221 and the driven wheel 23 are on the same horizontal line, and the synchronous belt 24 surrounds the driving wheel 221 and the driven wheel 23.

[0026] Please see Figure 2 A pair of relatively parallel guide rails 10 are installed on the upper surfaces of both sides of the bottom plate 11. The guide rails 10 extend horizontally from one end of the bottom plate 11 to the other end thereof. A pair of limit blocks 27 are installed on one side of the guide rails 10. The bottom of the limit blocks 27 is fixedly connected to the bottom plate 11, and the top thereof extends vertically upward. Secondly, a pair of limit blocks 27 are respectively located at both ends of the guide rails 10. Furthermore, a photoelectric sensor 28 is also installed on the upper surface of the bottom plate 11 for recording the position information of the heating module 3.

[0027] Please see Figures 4 to 5 The heating module 3 includes a flat plate 31, a plurality of heating blocks 32 fixedly connected to the flat plate 31, a plurality of locking blocks 33 for fixing the heating blocks 32, and a reagent kit base 34 located above the heating blocks 32. The flat plate 31 is a rectangular plate body in a horizontal state, and has a plurality of mounting holes 311 penetrating its upper and lower surfaces. The plurality of mounting holes 311 are arranged equidistantly, and the number and spacing thereof are changed according to needs. A plurality of heating blocks 32 are installed in the mounting holes 311, and the tops of the plurality of heating blocks 32 penetrate the mounting holes 311 and are placed above the flat plate 31. The shapes of 32 are different and change according to the types and specifications of the test tubes. An upper insulation plate 35 and a lower insulation plate 36 are provided below several heating blocks 32. The upper insulation plate 35 has a through hole 351 that passes through its upper and lower surfaces. Secondly, the bottom surface of the upper insulation plate 35 fits in the top surface of the lower insulation plate 36, and a heating film 37 is installed in the through hole 351. Several heating blocks 32 are respectively accommodated in the through hole 351, and their bottoms are fitted with the heating film 37. A heating pad 38 is fixedly connected to the bottom of the bottom plate 11, and the bottom of the lower insulation plate 36 is against the heating pad 38.

[0028] A plurality of stoppers 39 are installed on the upper surface of the flat plate 1 , and the plurality of stoppers 39 surround the mounting holes 311 to achieve accurate placement of the reagent kit base 34 . A plurality of reinforcing parts 3011 are installed on the lower surface of the flat plate 1 to improve the strength of the flat plate 1 .

[0029] A plurality of locking blocks 33 are located below a plurality of heating blocks 32, and are fixedly connected to the heating blocks 32 by bolts or screws that penetrate vertically upward from the lower surface of the locking blocks 33. A fixing plate 310 is installed below the lower insulation plate 36, and the screws or bolts fix and lock the upper insulation plate 35, the heating block 32, the heating film 37, the heating gasket 38, and the lower insulation plate 36 through the fixing plate 310.

[0030] Please see Figures 4 to 5 The fixing plate 310 and the flat plate 1 have first supporting members 3012 and second supporting members 3013 on both sides. The inner sides of the fixing plate 310 and the flat plate 1 are fixedly connected. Slide blocks are fixedly installed on the lower surfaces of one end of the first supporting members 3012 and the second supporting members 3013. The slide blocks are clamped with the guide rail 10 and slide along the guide rail 10. The first supporting members 3012 and the second supporting members 3013 are installed with pushing rollers 3014. The pushing rollers 3014 include first pushing rollers 30141 and The second pushing roller 30142 is used to push the movable door on one side of the box body for loading the device. The first pushing roller 30141 is located at the front end of the first support member 3012 and the second support member 3013. The second pushing roller 30142 is located at the bottom end of the first support member 3012 and the second support member 3013. A pair of auxiliary pulleys 3015 are provided between the first support member 3012 and the second support member 3013. The top of the auxiliary pulley 3015 is fixedly connected to the lower surface of the fixed plate 310, and the pulley below it slides along the bottom plate 11.

[0031] An adapter 3018 is fixedly mounted on the inner side of the first support member 3012 , and the adapter 3018 clamps the synchronous belt 24 vertically downward.

[0032] A baffle plate 3016 is provided below the fixed plate 310, and covers the lower surface of the fixed plate 310. Its side edges are bent vertically upward to cover the side surfaces of the first support member 3012 and the second support member 3013. A heating circuit board 3017 is installed between the baffle plate 3016 and the fixed plate 310 for heating the heating block 32.

[0033] Please see Figure 6 The adjusting member 4 includes a mounting plate 41, an adjusting motor 42 located on one side of the mounting plate 41, and a moving seat 43 driven by the adjusting motor 42. The mounting plate 41 is located between a pair of guide rails 10, and its bottom is fixedly connected to the upper surface of the base plate 11. The adjusting motor 42 has an adjusting screw rod 421, and the adjusting screw rod 421 is located above the mounting plate 41. The moving seat 43 is sleeved with the adjusting screw rod 421, and the adjusting motor 42 drives the moving seat 43 to move through the adjusting screw rod 421.

[0034] Please see Figure 7The lifting member 5 includes a support seat 51, a pair of lifting motors 52 installed on one side of the support seat 51, and a pair of transmission belts 53 driven by the lifting motors 52 respectively. The support seat 51 is located between a pair of guide rails 10, and its bottom is fixedly connected to the upper surface of the moving seat 43, and its top extends vertically upward. The pair of lifting motors 52 are both fixed to one side of the support seat 51, and the rotating shafts thereof pass through the support seat 51 and extend to the other side of the support seat 51. A secondary moving wheel is installed on the other side of the support seat 51, and the secondary moving wheel and the rotating shaft are on the same vertical line. The transmission belt 53 surrounds the secondary moving wheel and the rotating shaft, and the pair of transmission belts 53 are relatively parallel.

[0035] Please see Figure 8 The magnetic sleeve assembly 6 includes a magnetic sleeve frame 61 and a magnetic rod frame 62. The magnetic sleeve frame 61 includes a connecting frame 611, a fixing frame 612 installed on one side of the connecting clamp 611, and a plurality of pipe sleeves 613 connected to the fixing frame 612. One end of the connecting frame 611 is located on the side of the magnetic sleeve frame 61 and is connected to the transmission belt 53. The other end of the connecting frame 611 is horizontally fixedly connected to the fixing frame 612 outward. The connecting frame 611 is vertically moved by the transmission belt 53. The fixing frame 612 is fixed to the end of the connecting frame 611. It has a plurality of clamping holes 614 running through its upper and lower surfaces. A plurality of pipe sleeves 613 pass through the clamping holes 614 respectively and the tops are clamped in the clamping holes 614. The structure of the magnetic rod frame 62 is the same as that of the magnetic sleeve frame 61. It is driven to rise and fall vertically by another transmission belt 53. The extraction pipe 621 it has passes vertically downward through the clamping hole 614 and extends into the plurality of pipe sleeves 613 respectively.

[0036] When the nucleic acid extractor with automatic opening and closing cover of the utility model is used, the position of the magnetic sleeve assembly 6 is adjusted by the adjusting member 4 and the lifting member 5 according to the demand to achieve an ideal state, the motor 22 is mobilized to drive the synchronous belt 24 to rotate through the driving wheel 221 and the driven wheel 23, and the adapter clamps the fixed synchronous belt 24 at the same time, so that the sliders on the lower surfaces of the first support member 3012 and the second support member 3013 on both sides of the heating module 3 move along the guide rail 4, driving the heating module 3 to move horizontally as a whole, and the pushing rollers 3014 located at the front ends of the first support member 3012 and the second support member 3013 push open the movable plate 12, and the pushing rollers 3014 located at the bottom ends of the first support member 3012 and the second support member 3013 further press the movable plate 12, so as to achieve the effect of automatically opening and closing the movable plate 12.

[0037] The utility model is a nucleic acid extraction instrument with automatic opening and closing cover, which has the characteristics of high automation and high efficiency. A motor is mobilized to drive a heating module to move along a guide rail, so that a pushing roller at the front end of the heating module pushes and presses a movable plate. At the same time, the position of a magnetic sleeve component is automatically adjusted through an adjusting part and a lifting part, so that automatic operation is realized and the extraction efficiency of nucleic acid is improved.

[0038] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A nucleic acid extraction device with automatic opening and closing cover, characterized in that: It includes a base, an adjusting member fixed to the upper surface of the base, a heating module driven by the adjusting member, an adjusting member and a lifting member installed on one side of the heating module, and a magnetic sleeve assembly located above the heating module; the base includes a bottom plate and a movable plate located on one side of the bottom plate, and a plurality of spring hinge connections are provided at the connection between the bottom plate and the movable plate; the heating module includes a flat plate with a plurality of mounting holes, a plurality of heating blocks located in the mounting holes, a plurality of locking blocks and a fixing plate for fixing the heating blocks, a first support member and a second support member are respectively installed on both sides of the fixing plate, and pushing rollers are installed on the outer sides of the first support member and the second support member, and the pushing rollers include a first pushing roller and a second pushing roller, the first pushing roller is located at the front end of the first support member and the second support member, and the second pushing roller is located at the bottom of the first support member and the second support member.

2. The nucleic acid extraction device with automatic opening and closing cover according to claim 1, characterized in that: The adjusting member comprises an adjusting motor fixed on the upper surface of the bottom plate, a driving wheel installed below the adjusting motor, and a driven wheel installed on one side of the driving wheel. A synchronous belt is connected around the driving wheel and the driven wheel.

3. The nucleic acid extraction device with automatic opening and closing cover according to claim 2, characterized in that: Guide rails are installed on both sides of the synchronous belt, and the guide rails extend from one end of the bottom plate to the other end thereof.

4. The nucleic acid extraction device with automatic opening and closing cover according to claim 3, characterized in that: Slide blocks are fixedly mounted on the lower surfaces of the first support member and the second support member, and the slide blocks are clamped with the guide rails. An adapter is fixedly mounted on the inner side of the first support member, and the adapter clamps the synchronous belt.

5. The nucleic acid extraction device with automatic opening and closing cover according to claim 3, characterized in that: The adjustment member includes a mounting plate, an adjustment motor located on one side of the mounting plate, and a movable seat driven by the adjustment motor. The mounting plate is located between a pair of guide rails. The adjustment motor has an adjustment screw rod, which is located above the mounting plate. The movable seat is sleeved with the adjustment screw rod.

6. The nucleic acid extraction device with automatic opening and closing cover according to claim 5, characterized in that: The lifting member comprises a support seat, a pair of lifting motors installed on one side of the support seat, and a pair of transmission belts driven by the lifting motors respectively. The lifting motor has a rotating shaft that passes through the support seat to drive the transmission belts to rotate.

7. The nucleic acid extraction device with automatic opening and closing cover according to claim 6, characterized in that: The support seat is located between the pair of guide rails, the bottom of the support seat is fixedly connected to the upper surface of the moving seat, and the top of the support seat extends vertically upward.

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