Isolation device for medicine preparation

Abstract

The utility model provides an isolation device for medicine preparation. The isolation device comprises a support. A first cabin body is formed by a flexible sealing soft bag of an integrated structure, the first cabin body is detachably arranged on a support, a separation plate for separating the first cabin body into a feeding auxiliary cabin body and an operation main cabin body which are relatively independent is arranged in the first cabin body, a feeding port is formed in the feeding auxiliary cabin body, a discharging port is formed in the operation main cabin body, and a material conveying port is formed in the separation plate. The auxiliary feeding cabin and the main operation cabin are each provided with an operation soft bag connected with the first cabin, and the side wall, on the side where the operation soft bags are located, of the first cabin is of a transparent structure. The supporting platform is arranged below the first cabin body and is used for supporting the first cabin body; the fan assembly is connected with the first cabin body, and the fan assembly filters and exhausts gas in the first cabin body. The first cabin body is arranged to be of a flexible detachable structure, timely replacement is facilitated, the experiment requirement is met, convenience and rapidness are achieved, and the experiment cost is reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of biological medicine experiments, in particular to an isolation device used for medicine preparation. Background Art

[0002] In recent years, with the continuous development of science and technology, high-potency active pharmaceutical ingredients (HPAPI) with high selectivity for biological targets are widely used in the field of antibody-drug conjugates (ADCs). If these compounds and their derivatives accidentally come into contact with the skin, are inhaled or ingested, they will cause harm to the human body. Therefore, the characteristic experiments and production processes of such drugs must be carried out in a closed environment. The commonly used method in the prior art is to place the experiment of such drugs in a sealed experimental box for operation. After the experiment is completed, the experimental box needs to be cleaned and blown dry before the next experimental operation can be carried out or multiple experimental boxes with the same structure are set up at the same time for experimental operation. On the one hand, the waiting time required for cleaning is long, and the cleaning effect needs to be verified after the cleaning is completed. If the cleaning is not in place, cross contamination will occur; on the other hand, if multiple devices are added, the cost of the experiment will be high. Therefore, a low-cost, short waiting time experimental operation box is a problem that technicians in this field need to solve urgently. Utility Model Content

[0003] The primary purpose of the utility model is to provide an isolation device for drug preparation, which solves the problems of long cleaning waiting period, drug cross contamination and high experimental cost of characteristic drug experimental devices in the prior art.

[0004] Furthermore, the present application provides an isolation device for the preparation of High Potency Active Pharmaceutical Ingredient (HPAPI).

[0005] The drugs include, but are not limited to, high-potency active pharmaceutical ingredients (HPAPI) with high selectivity for biological targets, including but not limited to pharmacologically active ingredients or intermediates with biological activity, the content of which in the human body is about 150 μg / kg or less (therapeutic daily dose is 10 mg or less) calculated by body weight; API or intermediates, whose occupational exposure limit is equal to or less than 10 μg / m3 in air, taking the time-weighted average of 8 hours; sex hormones and certain other steroids; pharmacologically active ingredients or intermediates with high selectivity (i.e., able to bind to specific receptors or inhibit specific enzymes) and / or may cause cancer, mutation, developmental defects or reproductive toxicity at low doses; new compounds with unknown potency and toxicity. In order to achieve the above-mentioned purpose, the utility model adopts the following technical solutions:

[0006] An isolation device for drug preparation, comprising:

[0007] Bracket;

[0008] The first cabin is composed of a flexible sealed soft bag of an integral structure, the first cabin is detachably arranged on the bracket, the first cabin is provided with an isolation plate, the isolation plate separates the first cabin into a relatively independent feeding sub-cabin and an operating main cabin, the feeding sub-cabin is provided with a feeding port capable of connecting the feeding sub-cabin with the outside, the operating main cabin is provided with a discharge port capable of connecting the main cabin with the outside, the isolation plate is provided with a material transfer port connecting the feeding sub-cabin with the operating main cabin, wherein the feeding sub-cabin and the operating main cabin are both provided with an operating soft bag connected to the first cabin, and the side wall of the first cabin on the side where the operating soft bag is located is a transparent structure;

[0009] A support platform is disposed below the first cabin, and the support platform supports the first cabin;

[0010] The fan assembly is arranged outside the first cabin, the fan assembly is connected to the first cabin, and the fan assembly filters and discharges the gas in the flexible cabin.

[0011] In some embodiments, an adjustment buckle for fixing is provided on the first cabin, and the adjustment buckle enables the first cabin to be detachably mounted on the bracket.

[0012] In some embodiments, the feed port is connected to a first sealing zipper, and the feed port is opened or closed relative to the feed sub-chamber through the first sealing zipper; the isolation plate is a flexible structure, and the material transfer port is provided with a second sealing zipper, and the material transfer port is opened or closed relative to the operating main cabin through the second sealing zipper.

[0013] In some embodiments, the bracket includes a detachable support frame and a movably mounted lifting base on the lower side of the support frame, wherein a first lifting mechanism is disposed on the lifting base, and the first lifting mechanism drives the support frame to move up and down.

[0014] In some embodiments, the first lifting mechanism includes a main hydraulic cylinder, a secondary hydraulic cylinder, an adjusting handle and a screw slider assembly, the main hydraulic cylinder is arranged on the lifting base, the secondary hydraulic cylinder connected to the main hydraulic cylinder is arranged on the supporting foot of the lifting base, the adjusting handle is rotatably arranged on the lifting base and connected to the screw slider assembly, and the input end of the main hydraulic cylinder is connected to the screw slider assembly.

[0015] In some embodiments, the support platform includes a first support platform and a second support platform, the first support platform is arranged below the feed sub-cabin, and the second support platform is arranged below the operating main cabin, wherein the first support platform and the second support platform can both be raised and lowered.

[0016] In some embodiments, an airbag-type shockproof platform is provided in the main operating cabin, and the airbag-type shockproof platform includes an operating platform, an airbag and a protective shell. The protective shell is arranged on the second supporting platform, the airbag is arranged in the protective shell, and the operating platform is arranged on the airbag.

[0017] In some embodiments, it also includes a mobile magnetic stirring lifting platform disposed below the operating main cabin, the mobile magnetic stirring lifting platform includes a lifting platform and a second lifting mechanism, and the second lifting mechanism drives the lifting platform to move up and down.

[0018] In some embodiments, the fan assembly includes an air intake fan and an exhaust fan, an air inlet is arranged on the feed sub-chamber, an air exhaust is arranged on the operation main cabin, a ventilation hole is arranged on the isolation plate, the first exhaust port of the air intake fan is connected to the air inlet, the first air inlet of the exhaust fan is connected to the exhaust port, wherein a filter is arranged on the second exhaust pipe of the exhaust fan.

[0019] In some embodiments, a continuous bagging assembly is provided on the discharge port, and the continuous bagging assembly includes a continuous folding bag mounted on the discharge port, a silicone multi-row ring with a silicone clamp, and a sealing rope. The silicone multi-row ring is arranged at the discharge port and fixes one end of the continuous folding bag, and the sealing rope is arranged at the other end of the continuous folding bag and seals the continuous folding bag.

[0020] Compared with the prior art, the beneficial effects brought by the utility model are:

[0021] In the present application, the traditional fixed sealed box is configured as a flexible and detachable sealed box structure, which reduces the dead weight of the experimental box and facilitates the movement of the experimental platform. Combined with the support platform and the fan assembly, it provides the advantages of negative pressure, airtightness, and a safe and clean environment that meets the verification of industrial production of biomedicine. The first cabin of the flexible structure that has completed the experiment can also be disassembled and replaced from the bracket in time to achieve disposable use of the flexible cabin. The operation is simple and efficient, shortens the waiting time period, reduces the need for multiple devices, and does not require cleaning and cleaning effect verification, saving production time and manpower investment, reducing experimental costs, and at the same time avoiding cross-contamination of residual drugs, ensuring the accuracy of experimental data. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the internal structure of an isolation device for drug preparation according to the utility model;

[0023] Figure 2 This is a three-dimensional diagram of an isolation device for drug preparation according to the utility model;

[0024] Figure 3 This is a schematic structural diagram of an airbag-type shockproof platform of an isolation device for drug preparation according to the utility model;

[0025] Figure 4 It is a three-dimensional structural diagram of the main hydraulic cylinder operating component of an isolation device for drug preparation of the utility model;

[0026] Figure 5 This is a cross-sectional view of a mobile magnetic stirring lifting platform of an isolation device for drug preparation of the utility model;

[0027] Figure 6 This is a cross-sectional view of a secondary hydraulic cylinder and a transmission structure of an isolation device for drug preparation of the utility model;

[0028] Figure 7 This is a cross-sectional view of the lifting structure of the second operating table of an isolation device for drug preparation according to the utility model;

[0029] Figure 8 It is a three-dimensional structural schematic diagram of a fan assembly of an isolation device for drug preparation according to the utility model;

[0030] Fig. 9 The utility model is a cross-sectional view of a second exhaust pipe of an exhaust fan of an isolation device for medicine preparation. DETAILED DESCRIPTION

[0031] The present application is further described in detail below in conjunction with specific drawings. In the description of this embodiment, unless otherwise specified, the terms "left", "right", etc. indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, which are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the product structure in the present application must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention.

[0032] In one embodiment, Figure 1 As shown, an isolation device for drug preparation provided by the utility model mainly includes a bracket 200, a first cabin 100 arranged on the bracket 200, a supporting platform 300 and a fan assembly 400.

[0033] The first cabin 100 is composed of a sealed soft bag with a flexible structure. The first cabin 100 is detachably arranged on the bracket 200. An isolation plate 104 is arranged in the first cabin 100 to divide the first cabin 100 into two relatively independent spaces, including a feeding sub-cabin 101 and an operating main cabin 102. In this embodiment, the feeding sub-cabin 101 is mainly used for unpacking raw material medicine packages, and the operating main cabin 102 is mainly used for other experiments such as packaging, weighing, and stirring of medicines. Since the experiment requires more space, in this embodiment, the space of the feeding sub-cabin 101 is smaller than the space of the operating main cabin 102. Optionally, the space size of the feeding sub-cabin 101 may also be greater than or equal to the space size of the operating main cabin 102. A feed port connected to the outside is provided on the feed sub-chamber 101, which is used to transfer the sealed and packaged medicine packages to the feed sub-chamber 101 for unpacking; a discharge port 1021 connected to the outside is provided on the operating main cabin 102, and when the experiment is completed, the experimental instruments and the medicine bottles after the experiment are packed and taken out from the discharge port 1021; a transfer port connecting the feed sub-chamber 101 and the operating main cabin 102 is provided on the isolation plate 104, and when the raw material medicine packages are unpacked, the raw material medicine packages are transferred to the operating main cabin 102 through the transfer port; it should be noted that the feed port, the discharge port 1021 and the transfer port can all be opened and closed. Furthermore, both the main operating cabin 102 and the feed sub-cabin 101 are provided with operating soft bags 103, which enable the operator to put his hands into the first cabin 100 for unpacking and experiments. Specifically, the structure of the operating soft bag 103 is similar to the structure of latex gloves, which is convenient for the operator to operate flexibly. The side wall of the first cabin 100 on the side where the operating soft bag 103 is provided is a transparent structure, which is convenient for the operator to see the specific situation in the first cabin 100. In this embodiment, the first cabin 100 can be a transparent structure as a whole, and multiple operating soft bags 103 can be provided on the side wall of the first cabin 100, which is convenient for multiple people to unpack or perform experimental operations at the same time. In the present application, the isolation device is mainly used for experimental research including but not limited to high-potency active pharmaceutical ingredients (HPAPI) with high selectivity for biological targets.

[0034] The support platform 300 is arranged below the first cabin 100 to support the first cabin 100. Since the first cabin 100 is an integrated soft bag structure, a support platform 300 is arranged below the outer side of the first cabin 100 to provide a horizontal platform for unpacking and experimentation. After the experiment, the first cabin 100 can be directly removed from the bracket 200 and replaced with a new first cabin 100 with an integrated sealed soft bag, and the support platform 300 does not need to be moved, so the disassembly and installation of the first cabin 100 is more convenient and quick. Optionally, the support platform 300 can also be arranged as a splicing plate structure, arranged inside the first cabin, and spliced ​​and fixed on the bracket 200.

[0035] The fan assembly 400 is arranged on the outside of the first cabin 100. The fan assembly 400 is mainly used to filter and discharge the gas in the first cabin 100 to prevent the gas containing dust and medicines from directly flowing into the air and causing immeasurable harm to the operators. At the same time, before conducting the experiment, the fan assembly 400 blows air into the first cabin 100 and performs a sealing test on the first cabin 100 by determining whether there is any leakage, thereby further improving the safety of the experiment.

[0036] In the present application, the first cabin 100 is configured as an integrated flexible soft bag structure, which can be disassembled and mounted on a bracket 200, thereby reducing the difficulty of sealing the first cabin 100 from the integrated structure. At the same time, only one bracket 200 is required, and the first cabin 100 can be replaced by disassembling and assembling it. Compared with the traditional cleaning waiting time or adding multiple experimental equipment, the waiting time cycle is shortened, the experimental cost is lower, and the experimental flexibility is higher.

[0037] In one embodiment, in order to further facilitate the installation of the first cabin 100 on the bracket, an adjustment buckle 105 is provided on the first cabin 100. Specifically, the adjustment buckle 105 forms a ring structure when closed, thereby connecting the first cabin 100 to the bracket 200 of the square tube structure. In this embodiment, the adjustment buckle 105 is a double-row buckle, and the first cabin 100 can be connected to a loose connection by connecting the adjustment buckle 105 at different positions. Optionally, the adjustment buckle 105 can also be a one-row or multi-row structure. If the adjustment buckle 105 is a multi-row structure, the connection tightness of the first cabin 100 can be adjusted according to experimental requirements.

[0038] In one embodiment, a first sealing zipper 1012 is connected to the feed port, and the feed port is opened or closed relative to the feed sub-chamber 101 through the first sealing zipper 1012; when the first sealing zipper 1012 is opened, the feed port is opened, and the external raw material medicine packages can be delivered to the feed sub-chamber 101 at this time. When all the raw material medicine packages are delivered to the feed sub-chamber 101, the first sealing zipper 1012 is closed, and the feed port is closed at this time, and the feed sub-chamber 101 is in a sealed state. Further, the isolation plate 104 is configured as a flexible structure, and has the same material and structural composition as the first cabin 100. A second sealing zipper is provided on the material transfer port, and the material transfer port is opened or closed relative to the operating main cabin 102 through the second sealing zipper. When the second sealing zipper is opened, the material transfer port is opened, and the unpacked raw material medicine package can be delivered to the operating main cabin 102 through the material transfer port. After the raw material medicine package is completely delivered, the second sealing zipper is closed, and the material transfer port is closed at this time, and the feeding sub-cabin 101 and the operating main cabin 102 are relatively independent. In this embodiment, the first sealing zipper 1012 and the second sealing zipper have the same structure, and both can have the function of waterproof sealing. In order to maximize the feeding port and the material transfer port as much as possible, the first sealing zipper 1012 and the second sealing zipper are configured as a U-shaped structure. Optionally, the first sealing zipper 1012 and the second sealing zipper can also be configured as an I-shaped structure or an L-shaped structure.

[0039] In one embodiment, the support 200 includes a detachable support frame 201 and a fixedly connected lifting base 202. The support frame 201 is arranged above the lifting base 202, and a first lifting mechanism 2022 is arranged on the lifting base 202. The lifting and lowering movement of the first lifting mechanism 2022 drives the support frame 201 to perform overall lifting and lowering movement, so that the height of the first cabin 100 meets the needs of operators of different heights, and is convenient for operators to perform comfortable experimental operations.

[0040] Furthermore, if Figure 4 and Figure 6As shown, the first lifting mechanism 2022 is a hydraulic mechanism, including a main hydraulic cylinder 20224, a secondary hydraulic cylinder 20231, an adjustment handle 20221, and a screw slider assembly. Specifically, the main hydraulic cylinder 20224 is arranged on the square tube of the lifting base 202, and the secondary hydraulic cylinder 20231 is arranged on the supporting foot 2023 of the lifting base 202. The secondary hydraulic cylinder 20231 and the main hydraulic cylinder 20224 are connected through a hydraulic pipeline, wherein the hydraulic pipeline for connection is arranged in the hollow square tube of the lifting base 202, which is very convenient for sanitary maintenance and can greatly reduce the workload of cleaning dead corners; the adjustment handle 20221 is rotatably arranged on the lifting base 202 and is connected to the screw slider assembly, and the screw slider assembly includes a guide groove 202 25. A translation slider 20223 and a rotating screw rod 20222. The translation slider 20223 is arranged in a guide groove 20225. The translation slider 20223 and the rotating screw rod 20222 are connected by a threaded structure. The adjusting handle 20221 is fixedly connected to the rotating screw rod 20222. One end of the translation slider 20223 is connected to the input end of the main hydraulic cylinder 20224. The translation slider 20223 is driven to move along the guide groove 20225 by rotating the adjusting handle 20221, thereby driving the main push rod in the main hydraulic cylinder 20224 to move, thereby realizing transmission. Further, the support foot 2023 includes a support wheel 20233 and a first support tube 20234 movably connected to the support wheel 20233, the auxiliary hydraulic cylinder 20231 is fixedly connected to the first support tube 20234, the free end of the auxiliary push rod 20232 of the auxiliary hydraulic cylinder 20231 is fixedly connected to the support wheel 20233, and the auxiliary hydraulic cylinder 20231 is driven by the main hydraulic cylinder 20224 to adjust the lifting and lowering of the auxiliary push rod 20233, thereby driving the first support tube 20234 to move up and down, and realizing the lifting and lowering adjustment of the first cabin 100. Specifically, in this embodiment, the number of the support feet 2023 is 4, and the number of the auxiliary hydraulic cylinders 20231 is also 4. The number of the auxiliary hydraulic cylinders 20231 is determined according to the number of the support feet 2023, so that synchronous lifting and lowering can be realized. In this embodiment, by setting the first lifting mechanism 2022 to hydraulic transmission, not only stepless adjustment is achieved, but synchronous lifting can be achieved by operating only one adjustment handle 20221, which greatly simplifies the structure. At the same time, the hydraulic transmission structure is stable and can ensure that the first cabin 100 is stable in a certain position without the action of external force.

[0041] In one embodiment, Figure 1 and Figure 2As shown, in order to make the first cabin 100 module lightweight and facilitate the movement of the isolator, the support platform 300 is configured as a relatively independent first support platform 301 and a second support platform 302, wherein the first support platform 301 and the second support platform 302 are separated from the bracket 200, the first support platform 301 is arranged below the feeding sub-cabin 101 to support the feeding sub-cabin 101, and the second support platform 302 is arranged below the operating main cabin 102 to support the operating main cabin 102; at the same time, when the experiment is completed and the medicines are packaged from the discharge port 1021, the second support platform 302 can also be moved to the discharge port 1021 to support the packaging of medicines and instruments. Furthermore, since the first cabin 100 can be raised and lowered, the first support platform 301 and the second support platform 302 are configured as a liftable and adjustable structure. In this embodiment, the first support platform 301 and the second support platform 302 have the same structure, as shown in FIG. Figure 7 As shown, taking the first support platform 301 as an example, the first support platform 301 is provided with four first legs, the first legs include a first sleeve 3012 and a second sleeve 3011, the first sleeve 3012 is sleeved on the outside of the second sleeve 3011, the first sleeve 3012 can move axially along the second sleeve 3011, a fixing pin 3013 is provided on the first sleeve 3012, and a corresponding plurality of fixing pin holes 3014 arranged in a line are provided on the second sleeve 3011, by moving the first sleeve 3012, the fixing pin 3013 is plugged into the fixing pin hole 3014 at the corresponding position, so as to complete the clamping. Further, a support wheel 20233 is provided at the lower end of the first sleeve 3012, the support wheel 20233 can roll, and the first support platform 301 can move horizontally in any direction. In this embodiment, the number of the first legs is 4, corresponding to 4 fixing pins 3013, and 4 groups of fixing pin holes 3014 arranged in a line. The number of fixing pins 3013 and the number of groups of fixing pin holes 3014 are determined according to the number of the first legs, so that the structure of the first support platform 301 is more stable. Similarly, the lifting and lowering adjustment structure of the second support platform 302 is the same as that of the first support platform 302, and no further details are given here.

[0042] In one embodiment, since the drug needs to be weighed in the experiment, a stable weighing platform is required to ensure the accuracy of the weighing result. Therefore, an airbag anti-vibration platform 600 is set in the main operating cabin. The airbag anti-vibration platform 600 can effectively absorb vibration waves to prevent the generated vibration waves from affecting the weighing result. Figure 3As shown, the airbag-type shockproof platform 600 includes an operating platform 601, an airbag 602, and a protective shell 603. The protective shell 603 is placed on the second support platform 302 through the lower wall of the first cabin 100, the airbag 602 is arranged on the protective shell 603, and the operating platform 601 is placed on the airbag 602. Specifically, the protective shell 603 is a stainless steel shell, and the airbags 602 are in groups of three, which are respectively fixedly arranged on the protective shell 603. The operating platform 601 is preferably a marble platform. The marble platform has high flatness, is less affected by the ambient temperature, and has extremely small deformation, which can be used for high-precision balances. Furthermore, in order to improve the continuous pressure maintenance of the airbag 602, an air inlet 6021 is provided on the airbag 602, and the air inlet 6021 is connected to the pneumatic component so that the airbag 602 is always maintained at a constant air pressure to prevent the airbag 602 from losing pressure and being unable to absorb vibration waves, thereby affecting the weighing results.

[0043] In one embodiment, Figure 5 As shown, since a stirring process will occur during the drug experiment, due to the lifting and adjustment of the first cabin 100, a mobile magnetic stirring lifting platform 500 is set below the main cabin 102 to lift and adjust the magnetic stirrer placed thereon to meet the experimental needs. Specifically, the mobile magnetic stirring lifting platform 500 includes a lifting platform 509 and a second lifting mechanism arranged below the lifting platform 509, and the second lifting mechanism can drive the lifting platform 509 to lift and adjust. As shown in the figure, the second lifting mechanism includes a rotating wheel 501, a rotating shaft 502 fixedly connected to the rotating wheel 501, a first bevel gear 503 arranged on the rotating shaft 502, a second bevel gear 504 meshing with the first bevel gear 503, a second screw rod 505 fixedly connected to the second bevel gear 504, and an adjusting nut 506 fixedly arranged on the third sleeve 508, wherein, through the meshing of the two bevel gears, the horizontal rotation is changed into a vertical lifting movement, so that the second screw rod 505 can be axially lifted and moved relative to the adjusting nut 506, the fourth sleeve 507 is sleeved on the third sleeve 508, and can be axially moved relative to the third sleeve 508, and the rotating shaft 502 is fixedly arranged on the fourth sleeve 507. By rotating the rotating wheel 501, the second screw rod 505 is driven to move axially relative to the adjusting nut 506, thereby driving the fourth sleeve 507 to move axially relative to the third sleeve 508, so that the lifting platform 509 arranged on the upper end of the fourth sleeve 507 is lifted and lowered. Furthermore, a limiting device is provided between the third sleeve 508 and the fourth sleeve 507 to prevent the second screw rod 505 from excessive displacement. Specifically, corresponding limiting blocks are provided on the outer wall of the third sleeve 508 and the inner wall of the fourth sleeve 507. When the limiting blocks abut, the second screw rod 505 stops rotating. In order to facilitate the movement of the mobile magnetic stirring lifting platform, a support wheel 20233 is provided at the bottom of the first sleeve.

[0044] In one embodiment, Figure 8 As shown, the fan assembly 400 includes an air inlet fan 401 and an exhaust fan 402. Figure 1 and Figure 2 As shown, an air inlet 1011 is provided on the feeding sub-cabin 101, an air outlet 1022 is provided on the operating main cabin 102, and a vent 1041 is provided on the isolation plate 1041, wherein the first exhaust port 4012 of the air inlet fan 401 is connected to the air inlet 1011, the first air inlet 4011 of the air inlet fan 401 inhales air through the air inlet grille 403 of the box, and the first air inlet 4023 of the exhaust fan 402 is connected to the exhaust port 1022. Since the gas in the first cabin 100 may carry drug dust, the gas exhausted from the first cabin 100 needs to be filtered and then exhausted, so a filter 40211 is provided in the second exhaust pipe of the exhaust fan 402. Specifically, as shown in FIG. Fig. 9 As shown, the second exhaust duct is arranged in a Y-shaped bifurcated structure, and the second exhaust duct includes a second exhaust port 4022 for exhausting air and a second replacement port 4021 for replacing the filter 40211. For the convenience of operation, the diameter of the second replacement port 4021 is larger than the diameter of the second exhaust port 4022. A sealing cap 40212 is arranged on the second replacement port 4021 to seal the second replacement port 4021. The gas in the first cabin 100 passes through the filter 40211 and then to the second exhaust port 4022 for discharge. In this embodiment, due to experimental requirements, the first cabin 100 is always in a negative pressure state, that is, the air volume of the air intake fan 401 is smaller than the air volume of the exhaust fan 402. In order to facilitate the movement and adjustment of the fan assembly 400, a support wheel 20233 is arranged at the bottom of the fan assembly 400.

[0045] In one embodiment, since the instruments and drugs need to be packaged contactlessly after the experiment is completed, a continuous bagging assembly is provided at the discharge port 1021. The continuous bagging assembly seals the main operating cabin 102 during the experiment. After the experiment is completed, the experimental drugs and instruments are packaged contactlessly by the continuous bagging assembly and then transported away. Specifically, the continuous bagging assembly includes a continuous folding bag sleeved on the discharge port 1021, a silicone multi-row ring equipped with a silicone clamp, and a sealing rope. One end of the continuous folding bag is fixed to the pipe of the discharge port 1021 through the silicone multi-row ring equipped with a clamp, and the other end of the continuous folding bag is locked and sealed by a sealing rope.

[0046] The operation process of the utility model is as follows:

[0047] 1. Transfer and place the required instruments, check whether the feed port and the discharge port 1021 are closed, check whether the air inlet and exhaust assembly 400 is connected to the first cabin 100, check whether the corresponding filter 40211 is installed, and connect the corresponding protective gas;

[0048] 2. After the inspection is completed and the operation in step 1 is ensured to be completed, the fully automatic air inlet and outlet assembly 400 is opened to perform a leak detection on the first cabin 100. After the leak detection is completed, normal work can be performed;

[0049] 3. Open the first sealing zipper 1012 of the feeding sub-chamber 101 to transfer materials, close the first sealing zipper 1012 of the feeding sub-chamber 101 to unpack, open the second sealing zipper of the operating main cabin 102 after unpacking, transfer materials, and close the second sealing zipper of the operating main cabin 102;

[0050] 4. Perform relevant operations in the main cabin 102, discharge materials through continuous bagging, and complete the work;

[0051] 5. Wet the instruments in the first cabin 100 and the inner wall of the first cabin 100, transfer the instruments through continuous bagging to a dedicated cleaning department for cleaning, and replace the first cabin 100 for the next batch of work.

[0052] The above is only a preferred embodiment of the present invention. It should be noted that a person skilled in the art can make several improvements and modifications without departing from the principle of the present invention. These improvements and modifications should also be considered as the protection scope of the present invention.

Claims

1. An isolation device for drug preparation, characterized in that: include: Bracket; The first cabin is composed of a flexible sealed soft bag of an integral structure, the first cabin is detachably arranged on the bracket, the first cabin is provided with an isolation plate, the isolation plate separates the first cabin into a relatively independent feeding sub-cabin and an operating main cabin, the feeding sub-cabin is provided with a feeding port capable of connecting the feeding sub-cabin with the outside, the operating main cabin is provided with a discharge port capable of connecting the main cabin with the outside, the isolation plate is provided with a material transfer port connecting the feeding sub-cabin with the operating main cabin, wherein the feeding sub-cabin and the operating main cabin are both provided with an operating soft bag connected to the first cabin, and the side wall of the first cabin on the side where the operating soft bag is located is a transparent structure; A support platform is disposed below the first cabin, and the support platform supports the first cabin; The fan assembly is arranged outside the first cabin, the fan assembly is connected to the first cabin, and the fan assembly filters and discharges the gas in the first cabin.

2. An isolation device for drug preparation according to claim 1, characterized in that: The first cabin body is provided with an adjustment buckle for fixing, and the adjustment buckle enables the first cabin body to be detachably arranged on the bracket.

3. An isolation device for drug preparation according to claim 1, characterized in that: The feed port is connected to a first sealing zipper, and the feed port is opened or closed relative to the feed sub-chamber through the first sealing zipper; the isolation plate is a flexible structure, and the material transfer port is provided with a second sealing zipper, and the material transfer port is opened or closed relative to the operating main cabin through the second sealing zipper.

4. The isolation device for drug preparation according to claim 1, characterized in that: The bracket includes a detachable support frame and a movable lifting base fixedly arranged at the lower side of the support frame. The lifting base is provided with a first lifting mechanism, and the first lifting mechanism drives the support frame to move up and down.

5. An isolation device for drug preparation according to claim 4, characterized in that: The first lifting mechanism includes a main hydraulic cylinder, a secondary hydraulic cylinder, an adjusting handle and a screw slider assembly. The main hydraulic cylinder is arranged on the lifting base, and the secondary hydraulic cylinder connected to the main hydraulic cylinder is arranged on the supporting foot of the lifting base. The adjusting handle is rotatably arranged on the lifting base and connected to the screw slider assembly, and the input end of the main hydraulic cylinder is connected to the screw slider assembly.

6. The isolation device for drug preparation according to claim 1, characterized in that: The support platform includes a first support platform and a second support platform, wherein the first support platform is arranged below the feed sub-cabin, and the second support platform is arranged below the operation main cabin, wherein both the first support platform and the second support platform can be raised and lowered.

7. An isolation device for drug preparation according to claim 6, characterized in that: An airbag-type shockproof platform is provided in the main operating cabin, and the airbag-type shockproof platform includes an operating platform, an airbag and a protective shell. The protective shell is arranged on the second supporting platform, the airbag is arranged in the protective shell, and the operating platform is arranged on the airbag.

8. An isolation device for drug preparation according to claim 1, characterized in that: It also includes a mobile magnetic stirring lifting platform arranged below the operating main cabin, the mobile magnetic stirring lifting platform includes a lifting platform and a second lifting mechanism, and the second lifting mechanism drives the lifting platform to move up and down.

9. An isolation device for drug preparation according to claim 1, characterized in that: The fan assembly includes an air intake fan and an exhaust fan, an air intake port is arranged on the feed sub-chamber, an air exhaust port is arranged on the operation main cabin, a vent is arranged on the isolation plate, a first air exhaust port of the air intake fan is connected to the air intake port, and a first air intake port of the exhaust fan is connected to the air exhaust port, wherein a filter is arranged on the second exhaust pipe of the exhaust fan.

10. An isolation device for drug preparation according to claim 1, characterized in that: A continuous bagging assembly is provided on the discharge port, and the continuous bagging assembly includes a continuous folding bag mounted on the discharge port, a silicone multi-row ring with a silicone clamp, and a sealing rope. The silicone multi-row ring is arranged at the discharge port and fixes one end of the continuous folding bag, and the sealing rope is arranged at the other end of the continuous folding bag and seals the continuous folding bag.

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