Reusable chromatographic column

Abstract

A reusable chromatographic column comprises a column body, a column sleeve, a column sieve plate, a liquid inlet and outlet connector, a positioning pressing plate, a positioning lock sleeve, a positioning supporting rod and a limiting clamping plate, the column body is filled with a solid phase adsorbent, the two ends of the column body are provided with liquid inlet and outlet ends, the liquid inlet and outlet ends are connected with the column sieve plate, the inner side of the column sieve plate is provided with a plurality of positioning grooves, and the liquid inlet and outlet ends are provided with a plurality of positioning protruding blocks. The liquid inlet and outlet end is provided with a threaded protruding ring, the threaded protruding ring is connected with a threaded supporting sleeve through threads, the threaded supporting sleeve is connected with a column sieve plate, a fastening groove is formed in the outer side of the column sieve plate, the threaded supporting sleeve is provided with a fastening pressing ring, and the fastening pressing ring is matched with the fastening groove. The threaded supporting sleeve is provided with a liquid inlet and outlet connector, the liquid inlet and outlet connector is connected with a movable sleeve through threads, and a positioning pressing plate is arranged on the lower portion of the movable sleeve.

Description

Technical Field

[0001] The utility model relates to the field of chromatographic columns, in particular to a reusable chromatographic column. Background Art

[0002] The existing patent (Announcement No.: CN208902671U) proposes a chromatographic column, including: a chromatographic column tube, a filler and a baffle component, the chromatographic column tube includes a cavity, the filler is filled in the cavity of the chromatographic column tube; a socket is provided on the side wall of the chromatographic column tube, and the baffle component can be inserted into the cavity or taken out from the cavity through the socket; the baffle component located in the cavity is used to block the filler in the axial direction of the chromatographic column tube, and the gas entering the chromatographic column tube can pass through the filler and the baffle component and flow out. Compared with the prior art, when replacing the sample to be tested, it is necessary to remove the glass wool from the openings at both ends of the chromatographic column. The operation process is cumbersome and will cause damage to the chromatographic column tube. The utility model adopts a method of providing a socket on the side of the chromatographic column tube and providing a detachable baffle component in the socket, which is convenient for replacing the baffle component and reduces the damage to the chromatographic column tube when replacing the baffle component. However, the "chromatographic column tube" in this device lacks protective devices such as a column sleeve on the outside. After repeated use, the chromatographic column body is easily damaged, which reduces its service life and has disadvantages. Summary of the invention

[0003] In view of the above-mentioned deficiencies in the prior art, the utility model provides a reusable chromatographic column which increases the protection of the column by adding a column sleeve, thereby avoiding damage to the column after repeated use and prolonging its service life. The components are accurately positioned, tightly pressed, and easy to assemble and disassemble, making it easy to fill the solid phase adsorbent and replace the column, the inlet and outlet liquid joints, and the column sieve plate.

[0004] The purpose of this utility model is achieved through the following technical solutions:

[0005] A reusable chromatographic column comprises a column body, a column sleeve, a column sieve plate, an inlet and outlet liquid joint, a positioning pressure plate, a positioning locking sleeve, a positioning support rod, and a limiting clamping plate. The column body is filled with a solid phase adsorbent. Both ends of the column body are provided with inlet and outlet liquid ends, which are connected to the column sieve plate. The inner side of the column sieve plate is provided with a plurality of positioning grooves. The inlet and outlet liquid ends are provided with a plurality of positioning protrusions, which are adapted to the positioning grooves, and the positioning protrusions are connected to the positioning grooves. The inlet and outlet liquid ends are provided with a threaded convex ring, which is connected to a threaded support sleeve through threads, and the threaded support sleeve is connected to the column sieve plate. The outer side of the column sieve plate is provided with a fastening groove, and the threaded support sleeve has a fastening pressure ring, which is adapted to the fastening groove, and the fastening pressure ring is connected to the fastening groove. The threaded support sleeve has an inlet and outlet liquid joint, which is connected to a movable sleeve through threads, and a positioning pressure plate is provided at the bottom of the movable sleeve.

[0006] The utility model discloses a threaded support sleeve externally connected to a column sleeve, and the column sleeve internally connected to a liquid inlet and outlet end, the liquid inlet and outlet end has an inner slot, the threaded support sleeve has an outer slot, the column sleeve has a strip card block, the outer slot and the inner slot are adapted to the strip card block, the outer slot is connected to the strip card block, the strip card block is connected to the inner slot, both sides of the column sleeve have visual ports, both ends of the column sleeve have hexagonal plates, the inner side of the hexagonal plates is connected to a positioning pressure plate, and the positioning pressure plate has a positioning lock slot.

[0007] The hexagonal plate of the utility model is fitted with a rotating plate, a control slot is provided on the outer side of the rotating plate, a positioning support rod is provided on the inner side of the rotating plate, the positioning support rod is connected to the hexagonal plate and the positioning locking sleeve in sequence, the positioning support rod is connected to the positioning locking sleeve through a thread, the positioning locking sleeve is adapted to the positioning locking slot, and the positioning locking sleeve is connected to the positioning locking slot. Beneficial Effects

[0008] The utility model provides column sieve plates at the liquid inlet and outlet ends at both ends of the column body. The pore size of the column sieve plates is smaller than the pore size of the solid phase adsorbent in the column, which prevents the solid phase adsorbent from flowing out of the column and prevents particulate matter from entering the column to cause blockage, thereby improving the protection of the chromatographic column and extending its service life. The column sieve plate is inserted into the positioning groove through the positioning protrusion, and is embedded and plugged between the liquid inlet and outlet ends. The positioning is precise, which facilitates rapid and accurate docking and installation between components, and the axial position of the column sieve plate is limited to prevent the column sieve plate from rotating due to the rotational force during installation of the inlet and outlet liquid joints, thereby improving the structural stability. The liquid inlet and outlet ends are fixedly connected to the inlet and outlet liquid joints by threads, which is convenient for disassembly and assembly, can be reused and can be tightened as the inlet and outlet liquid joints rotate. The tightening ring is embedded in the tightening groove, and the upper part of the column sieve plate is pressed and fixed to prevent the column sieve plate from longitudinal movement and displacement, thereby strengthening the stability of the column sieve plate installation structure.

[0009] The utility model discloses a column sleeve wrapped around the outside of the column body to protect the column body, avoid damage to the column body after repeated use, and increase its service life, and through the visual ports provided on both sides, it is convenient to observe and judge the use of the column, and the bar-shaped card blocks are sequentially embedded in the outer card slot and the inner card slot, so as to increase the positioning fulcrum between the column sleeve and the liquid inlet and outlet ends and the threaded support sleeve, and avoid the column body and the liquid inlet and outlet joints rotating in the column sleeve during the detection operation, thereby improving the structural stability, and the movable sleeve is fixedly connected to the liquid inlet and outlet joints through the thread, which is convenient for disassembly and assembly, and is convenient for replacing the column, and the positioning pressure plate is used to press and tighten the outside of the threaded support sleeve, thereby improving the tightness of the connection between the components.

[0010] When the locking cam is in a position to move the locking cam in a forward direction, the locking cam is engaged with the locking member and the locking member is engaged with the locking member, thereby preventing the locking member from moving in a forward direction and preventing the locking member from moving in a forward direction.

[0011] The utility model increases the protection of the column by adding a column sleeve, avoids damage to the column after repeated use, and increases its service life. In addition, the components are accurately positioned and tightly pressed, and are easy to disassemble and assemble. The utility model can be reused, and is convenient for filling solid phase adsorbent and replacing the column, inlet and outlet liquid joints, and column sieve plates. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 The utility model is a schematic diagram of a reusable chromatographic column structure.

[0013] Figure 2 This is a cross-sectional view of a reusable chromatographic column structure described in the utility model.

[0014] Figure 3 This is a cross-sectional view of the connection structure of the hexagonal plate, positioning pressure plate, and inlet and outlet liquid joints described in the utility model.

[0015] Figure 4 This is a cross-sectional view of the connection structure of the column sleeve, threaded support sleeve and threaded convex ring described in the utility model.

[0016] Figure 5 This is a cross-sectional view of the column sleeve and the liquid inlet and outlet connection structure described in the utility model.

[0017] Figure 6 This is an exploded view of the structure of a reusable chromatographic column described in the utility model.

[0018] Figure 7 This is a schematic diagram of the structure of the liquid inlet and outlet joints described in the utility model.

[0019] Figure 8 This is a schematic diagram of the column sieve plate structure described in the utility model.

[0020] Fig. 9 This is a bottom view of the column sieve plate structure described in the utility model.

[0021] Fig.10 This is a schematic diagram of the positioning pressure plate structure described in the utility model.

[0022] Fig.11 This is a schematic diagram of the column sleeve structure described in the utility model.

[0023] Fig.12 This is a schematic diagram of the column structure described in the utility model.

[0024] Fig.13 For the utility model Figure 2 A magnified view of the local structure.

[0025] Fig.14 For the utility model Figure 6 A magnified view of the local structure. DETAILED DESCRIPTION

[0026] The utility model is further described in detail below according to the accompanying drawings and embodiments:

[0027] Embodiment 1:

[0028] A reusable chromatographic column comprises a column body 02, a column sleeve 03, a column sieve plate 04, a liquid inlet and outlet joint 13, a positioning pressure plate 15, a positioning locking sleeve 16, a positioning support rod 17, and a limiting clamp plate 20. The column body 02 is filled with a solid phase adsorbent 01. Both ends of the column body 02 have liquid inlet and outlet ends 10, and the liquid inlet and outlet ends 10 are connected to the column sieve plate 04. The inner side of the column sieve plate 04 has a plurality of positioning grooves 06. The liquid inlet and outlet ends 10 have a plurality of positioning protrusions 05, and the positioning protrusions 05 are adapted to the positioning grooves 06. The positioning protrusion 05 is connected to the positioning groove 06, the inlet and outlet liquid end 10 has a threaded protrusion 12, the threaded protrusion 12 is connected to the threaded support sleeve 11 through a thread, the threaded support sleeve 11 is connected to the column sieve plate 04, the column sieve plate 04 has a fastening groove 08 on the outside, the threaded support sleeve 11 has a fastening pressure ring 07, the fastening pressure ring 07 is adapted to the fastening groove 08, the fastening pressure ring 07 is connected to the fastening groove 08, the threaded support sleeve 11 has an inlet and outlet liquid joint 13, the inlet and outlet liquid joint 13 is connected to the movable The sleeve 14 has a positioning plate 15 at the bottom of the movable sleeve 14. The column sieve plate 04 is added at the liquid inlet and outlet ends 10 at both ends of the column 02. The pore size of the column sieve plate 04 is smaller than the pore size of the solid phase adsorbent 01 in the column 02. It prevents the solid phase adsorbent 01 from flowing out of the column 02 and prevents particles from entering the column 02 to cause blockage, thereby improving the protection of the chromatographic column and extending its service life. The column sieve plate 04 is inserted into the positioning groove 06 through the positioning protrusion 05, and is embedded and plugged with the liquid inlet and outlet ends 10 to position. It is precise and convenient for quick and accurate docking and installation between components. It also limits the axial position of the column sieve plate 04 to prevent the column sieve plate 04 from being affected by the rotational force during the installation of the inlet and outlet liquid joints 13 and rotating, thereby improving the structural stability. The inlet and outlet liquid ends 10 and the inlet and outlet liquid joints 13 are fixedly connected by threads, which is convenient for disassembly and assembly. The inlet and outlet liquid joints 13 are rotated and tightened, and the fastening ring 07 is embedded in the fastening groove 08 to press and fix the upper part of the column sieve plate 04 to prevent the column sieve plate 04 from longitudinal movement and displacement, thereby strengthening the stability of the installation structure of the column sieve plate 04.

[0029] Embodiment 2:

[0030] The threaded support sleeve 11 of the utility model is externally connected to the column sleeve 03, and the column sleeve 03 is internally connected to the liquid inlet and outlet end 10, and the liquid inlet and outlet end 10 has an inner card groove 25, and the threaded support sleeve 11 has an outer card groove 24, and the column sleeve 03 has a bar card block 23, and the outer card groove 24 and the inner card groove 25 are adapted to the bar card block 23, and the outer card groove 24 is connected to the bar card block 23, and the bar card block 23 is connected to the inner card groove 25. The column sleeve 03 has a visual port 09 on both sides, and the two ends of the column sleeve 03 have a hexagonal plate 26, and the inner side of the hexagonal plate 26 is connected to the positioning plate 15, and the positioning plate 15 has a positioning lock groove 27. The column sleeve 03 is wrapped around the outside of the column body 02 to protect the column body 02, to prevent the column body 02 from being damaged after repeated use, and to increase its service life. The visual ports 09 on both sides facilitate observation and judgment of the use of the column body 02, and the bar-shaped card block 23 is sequentially embedded in the outer card slot 24 and the inner card slot 25, to increase the positioning fulcrum between the column sleeve 03 and the liquid inlet and outlet ends 10 and the threaded support sleeve 11, to prevent the column body 02 and the liquid inlet and outlet joints 13 from rotating in the column sleeve 03 during the detection operation, thereby improving the structural stability. The movable sleeve 14 is fixedly connected to the liquid inlet and outlet joints 13 through threads, which is convenient for disassembly and assembly, and is convenient for replacement of the column body 02. The positioning pressure plate 15 is used to press and tighten the outside of the threaded support sleeve 11 to improve the tightness of the connection between the components.

[0031] Embodiment 3:

[0032] The hexagonal plate 26 of the utility model fits the rotating plate 18, the rotating plate 18 has a control slot 19 on the outside, and the rotating plate 18 has a positioning support rod 17 on the inside. The positioning support rod 17 is connected to the hexagonal plate 26 and the positioning lock sleeve 16 in sequence. The positioning support rod 17 is connected to the positioning lock sleeve 16 through a thread. The positioning lock sleeve 16 is adapted to the positioning lock slot 27. The positioning lock sleeve 16 is connected to the positioning lock slot 27. The two ends of the column sleeve 03 are provided with hexagonal plates 26. Compared with the cylinder, the hexagonal plate 26 has better stability when placed, is not easy to roll and slide, and improves the protection of the column 02. The positioning lock sleeve 16 increases the connection fulcrum between the hexagonal plate 26 and the positioning pressure plate 15, and is positioned and connected with the positioning support rod 17 through a thread, so that when a flat-head tool such as a flat-headed knife is inserted into the control slot 1 When the rotating plate 18 and the positioning support rod 17 are driven to rotate, the positioning locking sleeve 16 is displaced laterally and linearly. When the positioning locking sleeve 16 is displaced inwardly until it is embedded in the positioning locking groove 27, the positioning pressure plate 15 is braked and locked and cannot be rotated, preventing the movable sleeve 14 from being rotated under force, thereby improving the pressing tightness of the positioning pressure plate 15 on the internal components, so that the inlet and outlet liquid ends 10 are tightly connected with the inlet and outlet liquid joints 13 and the column sieve plate 04. When the positioning locking sleeve 16 is displaced outwardly until it is completely separated from the positioning locking groove 27, the braking fulcrum of the positioning pressure plate 15 disappears. At this time, the components can be removed in turn by rotating the movable sleeve 14 and the inlet and outlet liquid joints 13. The operation is convenient and easy to perform, and it is convenient for filling the solid phase adsorbent 01 and replacing the inlet and outlet liquid joints 13 and the column sieve plate 04.

[0033] Embodiment 4:

[0034] The hexagonal plate 26 of the utility model has a card plate through hole 22, and the positioning support rod 17 has a limit slot 21. The card plate through hole 22 and the limit slot 21 are adapted to the limit card plate 20. The limit card plate 20 passes through the card plate through hole 22, and the inner end of the limit card plate 20 is connected to the limit slot 21. The outer end of the limit card plate 20 is connected to the hexagonal plate 26 by screws. This device increases the protection of the column 02 by adding a column sleeve 03, so as to avoid damage to the column 02 after repeated use and improve its service life. In addition, the components are accurately positioned, tightly pressed, and easy to disassemble and assemble, so as to facilitate the filling of the solid phase adsorbent 01 and the replacement of the column 02, the inlet and outlet liquid joints 13, and the column sieve plate 04.

[0035] Embodiment 5:

[0036] Installation steps: First, assemble the positioning lock sleeve 16 control structure, first insert the positioning support rod 17 into the hexagonal plate 26, until the inner surface of the rotating plate 18 fits with the outer surface of the hexagonal plate 26, and the card plate perforation 22 corresponds to the position of the limiting card slot 21, then pass the limiting card plate 20 through the card plate perforation 22 until its inner end is embedded in the limiting card slot 21, and its outer end is fixedly connected to the hexagonal plate 26 by screws, then place the positioning lock sleeve 16 into the hexagonal plate 26, and put it on the outside of the positioning support rod 17, and the positioning lock sleeve 16 is positioned and connected to the positioning support rod 17 by threads. After completing the assembly of the positioning lock sleeve 16 control structure, place the column screen plate 04 in the inlet and outlet liquid end 10, and the positioning protrusion 05 is embedded in the positioning groove 06, and then place the inlet and outlet liquid joint 13 in the inlet and outlet The upper part of the liquid end 10 is assembled, and the threaded support sleeve 11 is sleeved on the outside of the threaded convex ring 12 and fixedly connected with it by threads until the fastening pressure ring 07 is embedded in the fastening groove 08, and then the assembled column 02 and the inlet and outlet liquid joint 13 are placed in the column sleeve 03, and the bar-shaped block 23 is sequentially embedded in the outer slot 24 and the inner slot 25, and then the movable sleeve 14 is sleeved on the outside of the inlet and outlet liquid joint 13, and fixedly connected with it by threads until the inner surface of the positioning pressure plate 15 is fitted with the outer surface of the threaded support sleeve 11, and the positioning lock groove 27 corresponds to the position of the positioning lock sleeve 16, finally, by inserting a flat-head tool such as a flat-headed knife into the control slot 19 to drive the rotating plate 18 to rotate, so that the positioning lock sleeve 16 is moved to its embedded positioning lock groove 27, the positioning pressure plate 15 is positioned, and the installation is completed.

[0037] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. It should be pointed out that a person skilled in the art can make several improvements and modifications without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as within the protection scope of the present invention.

Claims

1. A reusable chromatographic column, characterized in that : comprising a column (02), a column sleeve (03), a column sieve plate (04), an inlet and outlet liquid joint (13), a positioning pressure plate (15), a positioning locking sleeve (16), a positioning support rod (17), and a limiting clamping plate (20), wherein the column (02) is filled with a solid phase adsorbent (01), the column (02) has inlet and outlet liquid ends (10) at both ends, the inlet and outlet liquid ends (10) are connected to the column sieve plate (04), the column sieve plate (04) has a plurality of positioning grooves (06) on the inner side, the inlet and outlet liquid ends (10) have a plurality of positioning protrusions (05), the positioning protrusions (05) are adapted to the positioning grooves (06), the positioning protrusions (05) are connected to the positioning grooves ( 06), the inlet and outlet liquid end (10) has a threaded protruding ring (12), the threaded protruding ring (12) is connected to the threaded support sleeve (11) by threading, the threaded support sleeve (11) is connected to the column sieve plate (04), the outer side of the column sieve plate (04) has a fastening groove (08), the threaded support sleeve (11) has a fastening pressure ring (07), the fastening pressure ring (07) is adapted to the fastening groove (08), the fastening pressure ring (07) is connected to the fastening groove (08), the threaded support sleeve (11) has an inlet and outlet liquid joint (13), the inlet and outlet liquid joint (13) is connected to the movable sleeve (14) by threading, and the lower part of the movable sleeve (14) has a positioning pressure plate (15).

2. A reusable chromatographic column according to claim 1, characterized in that The threaded support sleeve (11) is externally connected to the column sleeve (03), and the column sleeve (03) is internally connected to the liquid inlet and outlet end (10), and the liquid inlet and outlet end (10) has an inner card slot (25), and the threaded support sleeve (11) has an outer card slot (24), and the column sleeve (03) has a bar card block (23), and the outer card slot (24) and the inner card slot (25) are adapted to the bar card block (23), and the outer card slot (24) is connected to the bar card block (23), and the bar card block (23) is connected to the inner card slot (25), and the column sleeve (03) has a visual port (09) on both sides, and the column sleeve (03) has a hexagonal plate (26) at both ends, and the inner side of the hexagonal plate (26) is connected to the positioning plate (15), and the positioning plate (15) has a positioning lock slot (27).

3. A reusable chromatographic column according to claim 2, characterized in that The hexagonal plate (26) is fitted to the rotating plate (18), the rotating plate (18) has a positioning slot (19) on the outside, the rotating plate (18) has a positioning rod (17) on the inside, the positioning rod (17) is connected to the hexagonal plate (26) and the positioning lock sleeve (16) in sequence, the positioning rod (17) is connected to the positioning lock sleeve (16) through a thread, the positioning lock sleeve (16) is adapted to the positioning lock slot (27), and the positioning lock sleeve (16) is connected to the positioning lock slot (27).

4. A reusable chromatographic column according to claim 3, characterized in that The hexagonal plate (26) has a card plate through hole (22), the positioning support rod (17) has a limit card slot (21), the card plate through hole (22) and the limit card slot (21) are adapted to the limit card plate (20), the limit card plate (20) passes through the card plate through hole (22), the inner end of the limit card plate (20) is connected to the limit card slot (21), and the outer end of the limit card plate (20) is connected to the hexagonal plate (26) by screws.

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