Liquid filtering device for biological pharmacy

Abstract

The utility model discloses a liquid filtering device for biopharmacy, which comprises a main feed pipe, a main discharge pipe and at least two filtering pipeline components, and each filtering pipeline component comprises an input pipeline, a front-end control valve mechanism, a visible pipeline mechanism, a filtering mechanism, a rear-end control valve mechanism and an output pipeline. According to the utility model, the Y-shaped filter is arranged, so that the filter can be suitable for large-batch high-viscosity filtering tasks, the material blocking risk is effectively reduced, and the filtering efficiency is improved. And the visual pipeline mechanism monitors the running state in real time, so that an operator can quickly respond and deal with the material blocking condition, and the smooth production process is ensured. In addition, the system adopts a multi-filtering pipeline assembly and a control valve mechanism, so that an affected pipeline can be immediately isolated and cleaned once material blockage occurs, and the filtering continuity is guaranteed. The closed pipeline design not only prevents external pollution, but also avoids potential harm to personnel caused by solution splashing, and meanwhile reduces material waste caused by material outflow.

Description

Technical Field

[0001] The utility model relates to the field of solution preparation, in particular to a liquid filtering device. Background Art

[0002] In the field of biopharmaceutical solution preparation, the raw materials and solvents must be mixed strictly in accordance with the process requirements, and the temperature, stirring speed and solvent addition order must be controlled to prevent air and impurity contamination. In order to ensure the uniformity of the solution composition, the solution needs to be filtered again after preparation. There are currently two common liquid filtration methods. The first is the filtration method of a manual filter screen, in which the mixed solution is poured into another liquid preparation barrel covered with a manual filter screen to complete the filtration; the second is to directly add a gasket filter screen to the discharge port of the liquid preparation tank to complete the filtration. For example, a biopharmaceutical filter valve disclosed in the Chinese utility model patent specification CN216618701U can reduce the tediousness of manual operation and automatically filter the material body, but it is only equipped with a single-channel filter device, which cannot meet the needs of long-term, uninterrupted filtration of high-concentration solutions. When the filter channel is blocked, the filtration operation needs to be stopped until the filter device is replaced or processed before the filtration operation can be resumed, resulting in low filtration efficiency during the production process.

[0003] In summary, the existing filtration methods have the following defects: The first method is too dependent on manual labor, low efficiency, and not suitable for large-scale filtration. Manual filtration also requires packaging. During this process, the solution is exposed to the outside world, which is easy to cause air and impurity pollution, and there is a risk of splashing of the solution, which is not only unsafe but also causes waste of materials. Although the second method frees up manpower and the material will not splash, it is often only suitable for low-viscosity solutions. When processing high-viscosity solutions, blockage is prone to occur, and the filter needs to be disassembled and cleaned many times, which greatly reduces the filtration efficiency.

[0004] Therefore, there is an urgent need for an equipment that is easy to operate, highly efficient and stable to assist in filtering the solution. Utility Model Content

[0005] In order to solve the problems of low filtration efficiency, labor consumption, material waste, and easy contamination when using conventional filtration devices in the biopharmaceutical field, the utility model aims to provide a biopharmaceutical liquid filtration device that is easy to operate, effectively reduces the impact of blockage of a single filter pipe component on the overall operation of the equipment, and effectively achieves high-efficiency filtration.

[0006] A liquid filtration device for biopharmaceuticals, characterized in that it comprises a main feed pipe, a main discharge pipe and at least two filtration pipeline components;

[0007] The feed inlet of each filter pipe assembly is connected to the first end of the main feed pipe, and the discharge outlet of each filter pipe assembly is connected to the first end of the main discharge pipe;

[0008] Each of the filter pipe assemblies comprises an input pipe, a front-end control valve mechanism, a visual pipe mechanism, a filter mechanism, a rear-end control valve mechanism and an output pipe which are connected in sequence;

[0009] The front-end control valve mechanism, the visual pipeline mechanism, the filter mechanism and the back-end control valve mechanism are all connected through corresponding transmission pipelines;

[0010] The end of each input pipe that is not connected to the front-end control valve mechanism constitutes the corresponding feed port of the filter pipe assembly, and the end of each output pipe that is not connected to the rear-end control valve mechanism constitutes the corresponding discharge port of the filter pipe assembly.

[0011] Based on the above-mentioned biopharmaceutical liquid filtration device, the visible pipeline mechanism includes a section of glass pipeline.

[0012] Based on the above-mentioned biopharmaceutical liquid filtration device, each of the input pipeline, the output pipeline and the transmission pipeline is made of 316L stainless steel or 304 stainless steel.

[0013] Based on the above-mentioned biopharmaceutical liquid filtration device, it also includes a pump, which is connected to the second end of the main feed pipe.

[0014] Based on the above-mentioned biopharmaceutical liquid filtration device, the pumps are all peristaltic pumps.

[0015] Based on the above-mentioned liquid filtration device for biopharmaceuticals, it also includes an inlet pressure gauge and an outlet pressure gauge. The inlet pressure gauge is arranged between the main feed pipe and the feed port of each of the filter pipe assemblies, and the outlet pressure gauge is arranged between the main discharge pipe and the discharge port of each of the filter pipe assemblies.

[0016] Based on the above-mentioned biopharmaceutical liquid filtration device, each of the filtration pipe components is located at the same horizontal plane.

[0017] Based on the above-mentioned liquid filtration device for biopharmaceuticals, the filtration mechanism includes a Y-type filter; the first end of the Y-type filter is connected to the visible pipe mechanism through the corresponding transmission pipe, the second end of the Y-type filter is connected to the rear-end control valve mechanism through the corresponding transmission pipe, and the third end of the Y-type filter is covered with a lid.

[0018] Based on the above-mentioned biopharmaceutical liquid filtration device, the input pipeline, the front-end control valve mechanism, the visible pipeline mechanism, the filtering mechanism, the back-end control valve mechanism, the output pipeline and each transmission pipeline are connected through corresponding pipeline clamp assemblies.

[0019] In summary, by adopting the above technical solution, the beneficial effects of the utility model are:

[0020] 1. At least two filter pipe components are used together with the corresponding control valve mechanism. When some filter pipe components are blocked, users can promptly select the remaining unblocked filter pipe components to continue the filtering operation. When the blocked filter pipe components are quickly cleaned and repaired, the use of the remaining filter pipe components will not be affected. This greatly reduces the impact of blockage on the overall filtering efficiency of the system and improves the filtering efficiency.

[0021] 2. The use of visual pipeline mechanisms and pressure gauges allows users to always know the operating status of the equipment, making it easier to deal with blockages in a timely manner.

[0022] 3. The liquid filtration device for biopharmaceuticals is equipped with a filtration mechanism that can directly dock with the container storing the material to be processed and perform the filtration operation, which can reduce the use of manpower, is suitable for large-scale filtration, reduces the risk of blockage, and effectively improves the filtration efficiency.

[0023] 4. The input pipeline, the front-end control valve mechanism, the visible pipeline mechanism, the filtering mechanism, the rear-end control valve mechanism, the output pipeline and the connection between each transmission pipeline are connected through the corresponding pipeline clamp assembly. The main feed port is directly connected to the container storing the material to be processed, so that the material does not contact with the outside world during the filtration process, and is directly transported to the main discharge port after filtration and then output. The filtration process is carried out in a relatively closed design environment, which can effectively reduce external contamination of the solution, avoid splashing of the solution to cause harm to the operator, and avoid material waste. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The concept, specific structure and technical effects of the present invention will be further described below in conjunction with the accompanying drawings to fully understand the purpose, characteristics and effects of the present invention.

[0025] Figure 1 It is a top view of the biopharmaceutical liquid filtering device of the utility model;

[0026] Figure 2 This is a front view of the biopharmaceutical liquid filtering device of the utility model;

[0027] Figure 3 It is a stereoscopic diagram of the biopharmaceutical liquid filtering device of the utility model.

[0028] Figure numerals 1-main feed pipe; 2-main discharge pipe; 3-input pipeline; 4-front-end control valve mechanism; 5-visible pipeline mechanism; 6-filter mechanism; 7-rear-end control valve mechanism; 8-output pipeline; 9-inlet pressure gauge; 10-outlet pressure gauge; 11-pipe clamp assembly. DETAILED DESCRIPTION

[0029] In order to make the technical means, creative features, objectives and effects of the utility model easier to understand, the utility model is further described below with reference to specific diagrams. However, the utility model is not limited to the following implementation cases.

[0030] It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings in this specification are only used to match the contents disclosed in the specification so that people familiar with this technology can understand and read them. They are not used to limit the conditions under which the present utility model can be implemented, so they have no substantive technical significance. Any structural modification, change in proportional relationship or adjustment of size should still fall within the scope of the technical contents disclosed in the present utility model without affecting the effects and purposes that can be achieved by the present utility model.

[0031] The structure of the biopharmaceutical liquid filtration device in one embodiment can be found in Figures 1 to 3 As shown, Figure 1 It is a top view of the biopharmaceutical liquid filtration device of the utility model; Figure 2 This is a front view of the biopharmaceutical liquid filtering device of the utility model; Figure 3 This is a stereoscopic diagram of the biopharmaceutical liquid filtration device of the utility model. The biopharmaceutical liquid filtration device mainly comprises a main feed pipe 1, a main discharge pipe 2, a peristaltic pump (not shown in the figure) and two filter pipe assemblies (in other embodiments, more filter pipe assemblies may be provided, not in this example). The pump is connected to the second end of the main feed pipe 1.

[0032] The feed inlet of each of the filter pipe assemblies is connected to the first end of the main feed pipe 1 , and the discharge outlet of each of the filter pipe assemblies is connected to the first end of the main discharge pipe 2 .

[0033] Each filter pipe assembly includes an input pipe 3, a front-end control valve mechanism 4, a visual pipe mechanism 5, a filter mechanism 6, a rear-end control valve mechanism 7 and an output pipe 8 which are connected in sequence. In this embodiment, the front-end control valve mechanism, the visual pipe mechanism, the filter mechanism and the rear-end control valve mechanism are all connected through corresponding transmission pipes; the transmission pipe is segmented, and each segment of the transmission pipe is connected through a pipe clamp assembly 11, so that the connecting pipes between each component in the device can be disassembled and cleaned, and there is no cleaning dead corner, which meets the cleaning requirements of the pharmaceutical industry.

[0034] The pipe clamp assembly 11 is formed by a clamp in the prior art, so its structure will not be described in detail here.

[0035] The main feed pipe 1, the input pipe 3, each section of the transmission pipe, the output pipe 8 and the main discharge pipe 2 can be connected respectively through corresponding pipe clamp assemblies 11 to ensure the sealing between the pipes and prevent foreign substances from entering and contaminating the solution.

[0036] It should be noted that, considering the limited size of the picture, the transmission pipelines in some positions in the figure are not drawn in detail, but in actual applications, the device can set transmission pipelines at relevant positions to transport the material.

[0037] The transmission pipeline can be made of medical or pharmaceutical grade stainless steel. In a preferred embodiment, the transmission pipeline can be made of 316L stainless steel or 304 stainless steel to meet the requirements of the biopharmaceutical field for containers.

[0038] In other embodiments, other methods may be used to connect the pipes and mechanisms in the biopharmaceutical liquid filtration device, such as by using detachable components such as flange structures and threaded connection components to achieve detachable connection between the components.

[0039] When filtering high viscosity solutions, you can choose Figure 1 For any one of the filter pipe components of the device shown, the front control valve mechanism 4 of the other filter pipe component is closed in advance. Driven by the peristaltic pump, the solution enters from the left main feed pipe 1, passes through the input pipe 3, the front control valve mechanism 4, the visual pipe mechanism 5, the filter mechanism 6, the rear control valve mechanism 7, and the output pipe 8 in the opened filter pipe component, and is discharged from the right main discharge pipe 2 to complete the filtration.

[0040] The filtering mechanism adopts a Y-type filter. The filter screen of the Y-type filter 4 has a larger filtering area than the ordinary gasket filter screen, which can effectively reduce the blockage, and the filter element is easier to replace and clean. The Y-type filter in the present application can be formed by the Y-type filter in the prior art, so the specific structure is not limited in the present application.

[0041] In some other embodiments, when the biopharmaceutical liquid filtration device is used in the scenario of filtering materials that are not easy to clog the pipeline, generally the blockage will only occur at the position where the filter element is set. Therefore, in specific applications, a fixed connection structure can also be used to form the biopharmaceutical liquid filtration device. For example, each section of the transmission pipeline and / or each mechanism can also be connected by welding. When a certain filter pipeline component is clogged, it is only necessary to replace the filter element in the Y-type filter 4 to resume operation.

[0042] An inlet pressure gauge 9 is provided between the main feed pipe 1 and the feed port of the filter pipe assembly, and an outlet pressure gauge 10 is provided between the main discharge pipe 2 and the discharge port of the filter pipe assembly.

[0043] In a specific implementation, the visible pipe mechanism 5 can be directly formed by a pipe made of a transparent material, and the pipe made of a transparent material can be directly connected to the corresponding transmission pipe through a pipe clamp assembly (11).

[0044] In some embodiments, the visual pipe mechanism 5 includes a pipe made of glass material, so that the user can observe the status inside the visual pipe mechanism 5 .

[0045] like Figure 3 As shown, in a preferred embodiment, the visual pipe mechanism 5 further includes a protective cover assembly, which includes two screw chucks and several steel pipes, wherein the two screw chucks are respectively provided with a placement hole and several screw holes, and several screw holes are arranged around the placement holes, and the number of the screw holes matches the number of the steel pipes. When in use, the two ends of the glass pipe are respectively arranged in the placement holes in the two screw chucks, and the two ends of the several steel pipes are respectively arranged in the corresponding screw holes in the two screw chucks, so that the several steel pipes can be distributed at intervals outside the glass pipe.

[0046] This structural design can use the protective cover assembly to protect the glass pipe. At the same time, the user can clearly observe the liquid flow in the visual pipeline mechanism from the gaps between the steel pipes in the protective cover assembly. In practical applications, the two ends of the glass pipe can extend out of the placement hole and connect with the transmission pipe outside the protective cover assembly through the corresponding pipe clamp assembly 11. Alternatively, a pipe part can be provided at the position where the placement hole is provided in the screw chuck, and the glass pipe is nested in the pipe part. The pipe part is then connected to the transmission pipe outside the protective cover assembly through the corresponding pipe clamp assembly 11, or other methods can be used to achieve the connection between the glass pipe and each transmission pipe. Several steel pipes can also be connected to the screw holes in the screw chuck by threaded connection or other connection methods.

[0047] The screw chuck may be formed by a chuck in the prior art, so its specific structure is not further limited here.

[0048] The filtered large-size materials will be deposited under the Y-type filter. When the large-size materials accumulate to a certain amount, there will be a certain blockage in the pipeline. The inlet pressure gauge 9 and the outlet pressure gauge 10 will show the changes in the pressure in the pipeline. If the liquid in the visible pipeline mechanism is in a static state and the inlet pressure is greater than the outlet pressure, it means that the pipeline is blocked. At this time, close the front-end control valve mechanism 4 and the rear-end control valve mechanism 7 of the filter pipeline assembly currently in use, and switch to the unblocked filter pipeline assembly to continue filtering.

[0049] At the same time, the Y-type filter in the filter pipe assembly where blockage occurs can be cleaned. There is no need to disassemble the Y-type filter. Just open its cover and take out the filter screen to clean it. A water gun or other tool can be used to flush the inner cavity of the Y-type filter, which greatly improves the efficiency of cleaning the blockage. If blockage occurs in the relevant filter pipe assembly, the pipe clamp assembly 11 between the corresponding pipes can be disassembled to remove the pipe for cleaning.

[0050] When filtering low-viscosity solutions, since blockage is less likely to occur, multiple filter pipe assemblies can be opened at the same time for filtering to improve filtering efficiency.

[0051] The pressure values ​​of the inlet pressure gauge 9 and the outlet pressure gauge 10 reflect the situation of the main pipeline, and can further reflect the operation of each filter pipeline component by cooperating with the visual pipeline mechanism 5 in the pipeline. The two can be used together to know the situation in each pipeline at all times, and can be cleaned when there is a possibility of blockage, so as to avoid too much blockage and difficulty in cleaning.

[0052] If any filter pipe assembly is blocked, the front control valve mechanism 4 and the rear control valve mechanism 7 of the blocked filter pipe assembly can be closed, and then the blocked Y-type filter can be cleaned. This will not affect the normal operation of another filter pipe assembly, greatly improving the filtering efficiency during the operation of the device.

[0053] The filter pipe assemblies need to be kept running on the same horizontal plane to avoid tilting which may cause uneven distribution of the solution in the filter pipe assemblies.

[0054] The utility model adopts a Y-type filter as the core filtering mechanism. Its structural characteristics are suitable for large-scale, high-efficiency filtering operations, significantly reducing the cleaning difficulty and cleaning time when the material is blocked, thereby effectively improving the overall filtering efficiency. This design not only enhances the stability of the system, but also optimizes the efficiency of the production process.

[0055] To further ensure the transparency and maintainability of the system operation, the utility model is equipped with a visual pipeline mechanism, which enables operators to monitor the operating status of the equipment in real time, including key parameters such as filtration efficiency and flow rate changes, so as to timely discover and deal with potential blockages and effectively prevent filtration interruptions.

[0056] The utility model adopts a multi-filter pipe assembly configuration and is supplemented by a control valve mechanism. This design enables the affected filter pipe assembly section to be quickly located and isolated through the control of the control valve when a material blockage event occurs, so as to quickly clean up the blocked area, minimize production downtime, and improve production flexibility and continuity.

[0057] In terms of pipeline connection, the system uses pipeline clamp components for sealed connection to build a fully enclosed pipeline system. This design not only effectively prevents external pollutants from entering the filtration system and ensures the purity of the filtration medium, but also avoids the potential harm to operators caused by splashing of solution during the filtration process, while reducing material loss; the clamp connection is simple to manufacture and easy to maintain, and there is no dead corner for cleaning, which is convenient for cleaning, meets the cleanliness and high quality requirements of the pharmaceutical industry, optimizes the production process, and improves economic benefits.

[0058] In summary, the filtration system achieves efficient, safe and sustainable filtration operations through a series of scientific and standardized design measures.

[0059] The above description is only a preferred embodiment of the present invention and does not constitute any form of limitation to the present invention. Although the present invention has been disclosed as a preferred embodiment as above, it is not intended to limit the present invention. Any technician familiar with the profession can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A liquid filtration device for biopharmaceuticals, characterized in that: It comprises a main feed pipe (1), a main discharge pipe (2) and at least two filter pipe components; The feed inlet of each of the filter pipe assemblies is connected to the first end of the main feed pipe (1), and the discharge outlet of each of the filter pipe assemblies is connected to the first end of the main discharge pipe (2); Each of the filtering pipeline assemblies comprises an input pipeline (3), a front-end control valve mechanism (4), a visual pipeline mechanism (5), a filtering mechanism (6), a rear-end control valve mechanism (7) and an output pipeline (8) which are connected in sequence; The front-end control valve mechanism (4), the visual pipeline mechanism (5), the filter mechanism (6) and the back-end control valve mechanism (7) are all connected via corresponding transmission pipelines; The end of each input pipe (3) that is not connected to the front-end control valve mechanism (4) constitutes the corresponding feed port of the filter pipe assembly, and the end of each output pipe (8) that is not connected to the rear-end control valve mechanism (7) constitutes the corresponding discharge port of the filter pipe assembly.

2. The biopharmaceutical liquid filtration device according to claim 1, characterized in that: The visible pipe mechanism (5) comprises a pipe made of glass.

3. The biopharmaceutical liquid filtration device according to claim 1, characterized in that: Each of the input pipeline (3), the output pipeline (8) and the transmission pipeline is made of 316L stainless steel or 304 stainless steel.

4. The biopharmaceutical liquid filtration device according to claim 1, characterized in that: It also comprises a pump, which is connected to the second end of the main feed pipe (1).

5. The biopharmaceutical liquid filtration device according to claim 4, characterized in that: The pump is composed of a peristaltic pump.

6. The biopharmaceutical liquid filtration device according to claim 1, characterized in that: It also includes an inlet pressure gauge (9) and an outlet pressure gauge (10), wherein the inlet pressure gauge (9) is arranged between the main feed pipe (1) and the feed port of each filter pipe assembly, and the outlet pressure gauge (10) is arranged between the main discharge pipe (2) and the discharge port of each filter pipe assembly.

7. The biopharmaceutical liquid filtration device according to claim 1, characterized in that: The filter pipe components are all located on the same horizontal plane.

8. The biopharmaceutical liquid filtration device according to claim 1, characterized in that: The filtering mechanism (6) comprises a Y-type filter; The first end of the Y-type filter is connected to the visual pipeline mechanism (5) through the corresponding transmission pipeline, the second end of the Y-type filter is connected to the rear-end control valve mechanism (7) through the corresponding transmission pipeline, and the third end of the Y-type filter is covered with a lid.

9. The biopharmaceutical liquid filtration device according to claim 8, characterized in that: The input pipeline (3), the front-end control valve mechanism (4), the visible pipeline mechanism (5), the filtering mechanism (6), the rear-end control valve mechanism (7), the output pipeline (8) and each transmission pipeline are connected via corresponding pipeline clamp assemblies (11).

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