Temperature control board assembly and biological sample storage system

Abstract

The utility model provides a temperature control board assembly. The temperature control board assembly comprises a temperature control board, a uniform temperature board and a heat conduction board. And a first flow channel for introducing a first medium is arranged in the temperature control plate. The temperature uniformizing plate is provided with three-dimensional through micropores, and the temperature uniformizing plate is arranged on the temperature control plate in a covering mode. The heat conduction plate covers the side, away from the temperature control plate, of the uniform temperature plate. According to the technical scheme, the temperature control medium (such as a low-temperature medium or a high-temperature medium) can be directly introduced into the first flow channel, the temperature can be transferred to the temperature control plate, the temperature of the temperature uniformizing plate can be more uniform due to the fact that the three-dimensional through micropores are formed in the temperature uniformizing plate, and heat exchange is conducted between the temperature uniformizing plate and the heat conduction plate, so that the temperature of the temperature uniformizing plate is more uniform. Therefore, the heat-conducting plate has lower temperature and uniform temperature distribution.

Description

[0001] This application claims priority to patent application number 202410176757X, filing date February 8, 2024, and patent name “Sampling door panel, biological sample storage system and pressure control method thereof”. Technical Field

[0002] The present application relates to the field of refrigeration technology, and in particular to a temperature control plate assembly and a biological sample storage system. Background Art

[0003] Biological samples usually refer to samples such as biological cells, tissues and organs. The storage of biological samples usually needs to be carried out under low temperature (for example: temperature at -86°C, -196° or even lower) and dry conditions so that the biological samples can remain active for a long time.

[0004] Therefore, biological samples are usually placed in sample boxes and then stored in biological sample storage systems (e.g., biological sample storage boxes) for preservation, so that the interior thereof can maintain a low temperature and dry environment for a long time. In order to cool the interior of the storage box, a cooling plate can be used for cooling, and the biological samples can be placed on the cooling plate. However, in the existing cooling plate cooling method, the temperature difference between different areas of the cooling plate is large, and the storage temperature of the biological samples in different areas is inconsistent. Utility Model Content

[0005] The purpose of the present application is to provide a temperature control plate assembly and a biological sample storage system to improve the situation where the storage temperature of biological samples in different areas is inconsistent.

[0006] The embodiment of the present application is implemented as follows:

[0007] In a first aspect, an embodiment of the present application provides a temperature control plate assembly, including a temperature control plate, a temperature averaging plate and a heat conducting plate. A first flow channel for passing a first medium is provided in the temperature control plate. The temperature averaging plate has three-dimensionally penetrating micropores, and a temperature averaging plate cover is provided on the temperature control plate. The heat conducting plate cover is provided on a side of the temperature averaging plate away from the temperature control plate.

[0008] In the above technical solution, the temperature control medium (for example, low temperature medium or high temperature medium) can be directly introduced into the first flow channel, and the temperature can be transferred to the temperature averaging plate. Since the temperature averaging plate has three-dimensional through-holes, the temperature of the temperature averaging plate can be made more uniform, and since heat exchange is performed between the temperature averaging plate and the heat conducting plate, the heat conducting plate can have a lower temperature and a uniform temperature distribution. The temperature control plate assembly provided by the above technical solution can be used to cool samples in a biological sample storage system. By placing the sample box on the heat conducting plate, the sample boxes placed in different areas can be stored under similar temperature conditions.

[0009] In some optional embodiments, the temperature equalizing plate is a foam metal structure.

[0010] In the above technical solution, the foam metal structural part has three-dimensional through-holes, has good thermal conductivity and ductility, can make the temperature distribution more uniform, and the temperature equalizing plate can better contact with the heat conducting plate, thereby making the temperature distribution of the heat conducting plate more uniform.

[0011] In some optional embodiments, the ratio of the thickness of the temperature averaging plate to the thickness of the temperature control plate assembly is 1:(2-8). The thickness of the temperature averaging plate is relatively reasonable, which can make the temperature of the temperature averaging plate easy to quickly and evenly distribute, so that the temperature on the heat conducting plate can also be more easily and quickly distributed evenly.

[0012] In some optional embodiments, the temperature averaging plate is in surface contact with the heat conducting plate and the temperature control plate, so that there is a larger contact area between the temperature averaging plate, the heat conducting plate and the temperature control plate, thereby improving the heat exchange efficiency.

[0013] In some optional embodiments, a heat insulation board is provided on one side of the temperature control board away from the temperature equalizing board. The heat insulation board can block the transfer of cold or heat, and can guide the temperature of the medium entering the first flow channel out from one side of the temperature equalizing board, so that the temperature in the temperature equalizing board can be quickly and evenly distributed, and also avoid the problem of temperature confluence on the side of the temperature control board assembly away from the heat conducting board.

[0014] In some optional embodiments, the temperature control plate is also provided with a second flow channel that is not interconnected with the first flow channel for passing a second medium, and the second medium in the second flow channel can exchange heat with the first medium in the first flow channel. By providing a second flow channel on the temperature control plate to pass the second medium, the temperature of the first medium can be changed by heat exchange between the first medium and the second medium, thereby changing the temperature of the heat conductive plate and adjusting the storage temperature of the sample. In a second aspect, an embodiment of the present application provides a biological sample storage system, comprising a shell and a temperature control plate assembly provided in the first aspect, the temperature control plate assembly is a refrigeration plate assembly, the first medium in the first flow channel is a refrigeration medium, the shell includes a storage chamber for placing samples, the temperature control plate assembly is arranged in the storage chamber, the heat conductive plate is located at the top, the temperature control plate is located at the bottom, and the surface of the heat conductive plate away from the temperature control plate is used to place samples.

[0015] In the above technical solution, placing the above refrigeration plate assembly in the storage chamber can make the storage temperature of the samples more uniform and the storage effect better.

[0016] In some optional embodiments, a plurality of the temperature control plate assemblies are arranged in the storage chamber, and the plurality of the refrigeration plate assemblies are arranged at intervals in the vertical direction, and can be stored in layers so as to store more samples.

[0017] In some optional embodiments, a sampling door plate is further included, and the sampling door plate and the shell form the storage chamber; the sampling door plate includes a plate body and a transfer device arranged on the plate body; the transfer device has an open state and a closed state, and the transfer device has a sampling channel connecting one side of the plate body with the other side of the plate body when in the open state; when the transfer device is in the closed state, the space on both sides of the plate body is separated at the position of the transfer device.

[0018] In the above technical solution, the transfer device has a sampling channel when in the open state, and can realize sampling from the biological sample storage system through the transfer device on the sampling door panel. Compared with the method of directly opening the sampling door panel for sampling, sampling through the sampling channel of the transfer device in the open state, when sampling, the channel connecting the storage chamber and the atmospheric environment is smaller, which can effectively reduce the moisture entering the storage chamber, thereby reducing the frosting phenomenon in the biological sample storage system.

[0019] In some optional embodiments, the plate body includes at least a first transparent material layer, a second transparent material layer, and a transparent heat-insulating layer located between the first transparent material layer and the second transparent material layer.

[0020] In the above technical solution, the plate body of the transfer device is made of transparent material, which is convenient for observing the samples placed in the storage chamber during the sampling process; the plate body also includes an insulation layer, which can reduce the heat exchange between the inside and outside of the storage chamber.

[0021] In some optional embodiments, the transfer device is configured as follows: a sampling device can extend from one side of the plate body through the transfer device to the other side of the plate body; when the sampling device extends into the transfer device, the transfer device passively changes to an open state; after the sampling device takes out the sample, the transfer device actively changes to a closed state.

[0022] In the above technical solution, during the sampling process of the biological sample storage system, the transfer device can be opened by the sampling device. After the sampling device takes out the sample, the transfer device actively changes to a closed state, which can reduce the time when the inside of the storage chamber is connected to the outside, thereby reducing the ambient gas entering the storage chamber from the outside, thereby reducing the frosting phenomenon in the storage chamber.

[0023] In some optional embodiments, the transfer device includes at least one layer of elastic diaphragm, and each layer of the diaphragm includes a plurality of elastic parts arranged along the circumferential direction. When the elastic part is supported by the sampling device, the elastic part is deformed to put the transfer device in an open state; when the elastic part is reset, the transfer device is in a closed state.

[0024] In the above technical solution, the transfer device includes an elastic diaphragm, and the transfer device can be opened by deformation of the elastic part when it contacts the sampling device. After the sampling is completed, the elastic part is reset under its own elastic action, so that the transfer device is automatically closed. In the biological sample storage system provided by the above technical solution, the structure of the transfer device is simple.

[0025] In some optional embodiments, the shell also includes an operating chamber for sampling, and the operating chamber is selectively connected to the storage chamber. The sampling door panel is arranged in the operating chamber. A manipulator is arranged in the operating chamber, and the manipulator is used to transfer the sample in the storage chamber to the operating chamber, and send the sample in the operating chamber out of the operating chamber through the transfer device of the sampling door panel.

[0026] In the above technical solution, fully automatic sampling can be performed by a robot arm to avoid the low temperature environment in the storage room affecting the user's hands. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0028] Figure 1 A front view of a biological sample storage system provided by an embodiment of the present application;

[0029] Figure 2 A schematic diagram of the internal structure of a biological sample storage system provided in another embodiment of the present application;

[0030] Figure 3 for Figure 1 The axonometric view of the biological sample storage system shown after the sampling door panel and the thermal insulation door are removed;

[0031] Figure 4 A front view of the biological sample storage system provided in an embodiment of the present application after the thermal insulation door is removed;

[0032] Figure 5 A cross-sectional schematic diagram of a temperature control panel assembly provided in one embodiment of the present application;

[0033] Figure 6 A cross-sectional schematic diagram of a temperature control panel assembly provided in one embodiment of the present application;

[0034] Figure 7 A cross-sectional schematic diagram of a temperature control panel assembly provided in one embodiment of the present application;

[0035] Figure 8 A cross-sectional schematic diagram of a temperature control panel assembly provided in one embodiment of the present application;

[0036] Fig. 9 A cross-sectional schematic diagram of a temperature control panel assembly provided in one embodiment of the present application;

[0037] Fig.10 A cross-sectional schematic diagram of a temperature control plate provided in one embodiment of the present application;

[0038] Fig.11 A cross-sectional schematic diagram of a temperature control plate provided in one embodiment of the present application;

[0039] Fig.12 A cross-sectional schematic diagram of a temperature control plate provided in one embodiment of the present application;

[0040] Fig.13 A cross-sectional schematic diagram of a temperature control plate provided in one embodiment of the present application;

[0041] Fig.14 A cross-sectional schematic diagram of a temperature control plate provided in one embodiment of the present application;

[0042] Fig.15 A top view of a temperature control plate provided in one embodiment of the present application;

[0043] Fig.16 A top view of a temperature control plate provided in one embodiment of the present application;

[0044] Fig.17 The three-dimensional structure of the sampling door panel provided in the embodiment of the present application;

[0045] Fig.18 A cross-sectional view of a sampling door panel provided in an embodiment of the present application;

[0046] Fig.19 A schematic diagram of a diaphragm provided in one embodiment of the present application;

[0047] Fig. 20 A schematic diagram of a diaphragm provided in accordance with an embodiment of the present application.

[0048] Icons: 100-shell; 110-storage chamber; 120-operating chamber; 200-sampling door plate; 210-plate body; 211-first transparent material layer; 212-second transparent material layer; 213-insulating layer; 220-transfer device; 221-diaphragm; 2211-elastic part; 2212-connecting ring; 300-temperature control board assembly; 310-temperature control board; 311-first surface; 312-second surface; 313-first flow channel; 314-second flow channel; 320-temperature averaging plate; 330-heat conducting plate; 341-first sealing plate; 342-second sealing plate; 350-bump; 360-liquid delivery pipeline; 370-insulating board; 400-insulating door; 500-manipulator. DETAILED DESCRIPTION

[0049] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various different configurations.

[0050] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application for which protection is sought, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present application.

[0051] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0052] In the description of this application, it should be noted that the terms "center", "upper", "lower", "vertical", "horizontal", "inner", "outer", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, or the positions or positional relationships in which the product of the application is usually placed when in use. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as a limitation on this application. In addition, the terms "first", "second", "third", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0053] In addition, the terms "horizontal", "vertical", "overhanging" and the like do not mean that the components are required to be absolutely horizontal or overhanging, but can be slightly tilted. For example, "horizontal" only means that its direction is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but can be slightly tilted.

[0054] In the description of this application, it should also be noted that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0055] The present application provides a biological sample storage system, such as Figures 1 to 3 As shown, it includes a housing 100, and the housing 100 includes a storage chamber 110 for storing samples. It is not difficult to understand that the sample is placed in a sample box, and then the sample box is placed in the storage chamber 110 to achieve low-temperature storage of the sample. The biological sample storage system also includes a temperature control plate assembly 300 (for the biological sample storage system, the temperature control plate assembly 300 here is mainly a refrigeration plate assembly) arranged in the storage chamber 110, and the sample box is placed on the temperature control plate assembly 300, and the temperature control plate assembly 300 is directly in contact with the sample box, and the cold is directly transferred to the sample box to achieve low-temperature storage of the sample. Further, a plurality of temperature control plate assemblies 300 arranged in the vertical direction can be arranged in the storage chamber 110 to achieve the placement of multiple layers of sample boxes. Optionally, the plurality of temperature control plate assemblies 300 are preferably evenly spaced in the vertical direction.

[0056] In some embodiments, Figures 5 to 9 As shown, the temperature control board assembly 300 includes a temperature control board 310, a temperature averaging board 320 and a heat conducting board 330. In the temperature control board assembly 300, the heat conducting board 330 is located at the top, and the sample box contacts the heat conducting board 330 for heat exchange.

[0057] Furthermore, a first flow channel 313 is provided in the temperature control plate 310, and the first flow channel 313 is used for the first medium to pass through. Figure 8 , Fig.11 As shown, the first flow channel 313 can be formed by opening a hole in the temperature control plate 310, or when preparing the temperature control plate 310, the first pipeline is directly embedded in the temperature control plate 310, and the lumen of the first pipeline is the first flow channel 313; in other embodiments, such as Figure 6 , Figure 7 , Fig. 9 , Fig.10As shown, the first flow channel 313 may also be a portion of the first surface 311 of the temperature control plate 310 that is recessed downward to form a groove, and then the first sealing plate 341 is covered on the first surface, and is surrounded by the groove and the first sealing plate 341. Further, the first surface 311 is the surface of the temperature control plate 310 facing the temperature plate 320. The portion of the first surface 311 that is recessed downward is the recessed direction when the biological sample storage system is working normally, that is, Fig.10 , Figure 12 to Figure 14 As shown, a partial area of ​​the first surface 311 is recessed toward the inside of the solid portion of the temperature control plate 310 . When the biological sample storage system works normally, the medium in the first flow channel 313 is carried by the temperature control plate 310 .

[0058] The temperature averaging plate 320 has three-dimensional through-holes. That is, the temperature averaging plate 320 has small-sized micropores, and the extension direction of the micropores is not fixed, and the micropores can penetrate the temperature averaging plate 320 in multiple directions. It is not difficult to understand that in the temperature control plate assembly 300 provided in the present application, the heat conducting plate 330 is covered on the side of the temperature averaging plate 320 away from the temperature control plate 310. The top, bottom, left, right and other directions in the present application are all directions of the biological sample storage system in normal use, that is, based on the directions or positional relationships shown in the accompanying drawings.

[0059] The temperature control medium can be directly introduced into the first flow channel 313, and the temperature of the temperature control medium can be transferred to the temperature averaging plate 320. Since the temperature averaging plate 320 has three-dimensional through micropores, the temperature of the temperature averaging plate 320 can be made more uniform, and since heat exchange is performed between the temperature averaging plate 320 and the heat conducting plate 330, the heat conducting plate 330 can have a lower temperature and a uniform temperature distribution. The heat conducting plate 330 is preferably a metal structural part, such as a copper structural part, a stainless steel structural part, an aluminum structural part, etc. The heat conducting plate 330 is a metal structural part and can have good thermal conductivity. In the embodiment in which the temperature control plate assembly 300 is used in a biological sample storage system, in order to meet the need for low-temperature storage of biological samples, the temperature control plate assembly 300 is a refrigeration plate assembly, and the temperature control medium in the first flow channel 313 is a low-temperature medium; in the embodiment in which the temperature control plate assembly 300 is used in other equipment, the temperature control medium can also be a high-temperature medium.

[0060] It is not difficult to understand that in the biological sample storage system provided by the present application, by providing the temperature equalizing plate 320, the temperature distribution of the heat conducting plate 330 can be made more uniform, and when the sample box is placed on the heat conducting plate 330, the sample can be stored at a similar temperature.

[0061] In some embodiments of the present application, the temperature averaging plate 320 is a foam metal structural member, such as foam copper or foam aluminum. The foam metal material has the characteristics of good thermal conductivity and ductility. Based on its good thermal conductivity, it can make it faster to exchange heat with the heat conducting plate 330 and the first medium; based on its good ductility, it can be deformed to a certain extent to facilitate a larger area of ​​contact with the heat conducting plate 330. For example, by making the heat conducting plate 330 and the temperature averaging plate 320 in surface contact and having a certain interaction force, the temperature averaging plate 320 can be extended and deformed under the force, thereby increasing the contact area between the temperature averaging plate 320 and the heat conducting plate 330, thereby improving the heat exchange efficiency between the temperature averaging plate 320 and the heat conducting plate 330; further, the temperature averaging plate 320 and the temperature control plate 310 can also be in surface contact, specifically, the temperature averaging plate 320 is in surface contact with the first surface 311 of the temperature control plate 310. In other implementations, the temperature homogenizing plate 320 may also be other structural members having three-dimensional penetrating micropores.

[0062] Further, the ratio of the thickness of the temperature averaging plate 320 to the thickness of the temperature control plate assembly 300 is 1:(2-8), that is, the ratio of the thickness of the temperature averaging plate 320 to the thickness of the temperature control plate assembly 300 is in the range of 1:8 to 1:2. The thickness of the temperature averaging plate 320 and the thickness of the temperature control plate assembly 300 are dimensions in the same direction, and further, they are both dimensions in the direction perpendicular to the first surface 311, or they are both dimensions in the direction perpendicular to the surface of the heat conducting plate 330 for placing the sample. The thickness of the temperature averaging plate 320 is relatively reasonable, which can make the temperature of the temperature averaging plate 320 easy to quickly and evenly distribute, so that the temperature on the heat conducting plate 330 is also easier and faster, thereby performing cooling.

[0063] Further, based on actual usage, the thickness of the temperature control panel assembly 300 is in the range of 35 to 50 mm; the thickness of the temperature balancing plate 320 is in the range of 5 to 15 mm. Those skilled in the art can reasonably select the thickness of the temperature control panel assembly 300 and the temperature balancing plate 320 according to the ratio of the thickness of the temperature balancing plate 320 to the thickness of the temperature control panel assembly 300 in the above-mentioned embodiment. Of course, in other embodiments, the ratio of the thickness of the temperature balancing plate 320 to the thickness of the temperature control panel assembly 300 can also be outside 1: (2 to 8), such as, when the thickness of the temperature balancing plate 320 is 5 mm, the thickness of the temperature control panel assembly 300 can also be 50 mm, and the thickness ratio of the two is 1: 10, which is outside 1: (2 to 8); when the thickness of the temperature balancing plate 320 is 15 mm, the thickness of the temperature control panel assembly 300 can also be 35 mm, and the thickness ratio of the two is 3: 7, which is outside 1: (2 to 8). Of course, when the ratio of the thickness of the temperature equalizing plate 320 to the thickness of the temperature control plate assembly 300 is within 1:(2-8), the thickness of the temperature control plate assembly 300 can be selected within the range of 35-50 mm and the thickness of the temperature equalizing plate 320 can be selected within the range of 5-15 mm.

[0064] In an embodiment in which the temperature averaging plate 320 is made of foam metal material, since the temperature averaging plate 320 has a certain ductility, when there is an interaction force between the temperature averaging plate 320 and the temperature control plate 310 and the heat conducting plate 330, that is, when the temperature averaging plate 320 and the temperature control plate 310 and the heat conducting plate 330 are in surface contact, the thickness of the temperature averaging plate 320 may change. In this embodiment, the thickness of the temperature averaging plate 320 may be the thickness measured after disassembling the temperature averaging plate 320, or it may be the distance between the side of the heat conducting plate 330 facing the first surface 311 and the first surface 311 in the thickness direction of the temperature control plate assembly 300.

[0065] In some embodiments, due to changes in the storage conditions of the sample, it is necessary to change the storage temperature of the sample. Therefore, the temperature control plate assembly 300 also includes a second flow channel 314 through which a temperature control medium can pass. The temperature control medium in the first flow channel 313 is referred to as the first medium, and the temperature control medium in the second flow channel 314 is referred to as the second medium. The first flow channel 313 and the second flow channel 314 are not connected to each other, and heat exchange can be performed between the first medium and the second medium. By introducing a second medium having a temperature different from that of the first medium into the second flow channel 314, heat exchange can be performed between the first medium and the second medium, thereby changing the temperature of the first medium. Accordingly, the temperature of the heat conducting plate 330 can be changed, thereby changing the storage temperature of the sample.

[0066] Furthermore, in some embodiments, the temperature control plate 310 is a heat-conducting structural member, and the first flow channel 313 and the second flow channel 314 are both disposed on the temperature control plate 310, so that the first medium and the second medium can exchange heat through the temperature control plate 310. Fig. 9 and Fig.12 In the embodiment shown, the second flow channel 314 is a groove-shaped structure disposed on the temperature control plate 310; Figure 7 , Figure 8 , Fig.10 , Fig.11 and Fig.13 In the illustrated embodiment, the second flow channel 314 is a through hole provided in the temperature control plate 310, and the cross section of the second flow channel 314 in its own extension direction is a closed cross section. The second medium flowing in the second flow channel 314 first exchanges heat with the temperature control plate 310, and the temperature control plate 310 then exchanges heat with the first medium, thereby changing the temperature of the first medium to adjust the storage temperature of the sample.

[0067] Furthermore, in order to make the heat exchange efficiency between the first medium and the second medium higher, the distance between the first flow channel 313 and the second flow channel 314 is smaller. In some embodiments, the first flow channel 313 and the second flow channel 314 are arranged in the same layer, that is, the axis positions of the first flow channel 313 and the second flow channel 314 are approximately at the same height in the thickness direction of the temperature control plate 310. In this case, the second flow channel 314 is closed in the circumferential direction, that is, the cross section of the second flow channel 314 perpendicular to its own extension direction is a closed shape. Since the second flow channel 314 is closed in the circumferential direction, the second medium in the second flow channel 314 will not leave the second flow channel 314 and mix with the first medium, and the first flow channel 313 and the second flow channel 314 will not be connected. Since the first flow channel 313 and the second flow channel 314 are arranged on the same layer, the distance between the temperature averaging plate 320 and the heat conducting plate 330 of the second flow channel 314 is also relatively close, which facilitates heat exchange between the second medium in the second flow channel 314 and the temperature averaging plate 320 and other structures, thereby improving the efficiency of regulating the sample storage temperature.

[0068] In the embodiment where the first flow channel 313 and the second flow channel 314 are arranged on the same layer, Figure 7 , Fig.10 As shown, the first flow channel 313 and the second flow channel 314 do not intersect each other, and the first flow channel 313 and the second flow channel 314 extend in substantially the same direction, and the second flow channel 314 is arranged close to the first flow channel 313 to facilitate heat exchange between the first medium and the second medium. Fig.15 In the embodiment shown, the first flow channel 313 and the second flow channel 314 both extend along an S-shaped trajectory; Fig.16 In the illustrated embodiment, there are plural first flow channels 313 and plural second flow channels 314 , and the first flow channels 313 and the second flow channels 314 are parallel to each other and arranged alternately.

[0069] Further, in an embodiment where the first flow channel 313 and the second flow channel 314 are arranged in the same layer, Fig.14 As shown, the second flow channel 314 can also be a tube cavity in the liquid delivery pipe 360 ​​that is in contact with the temperature control plate 310. It is not difficult to understand that the liquid delivery pipe 360 ​​is also a heat-conducting structural component so that the second medium can pass through the temperature control plate 310 to achieve heat exchange with the first medium.

[0070] In order to make the heat exchange efficiency between the first medium and the second medium higher, the distance between the first flow channel 313 and the second flow channel 314 is smaller. Figure 8 and Fig. 9 The upper and lower arrangement shown in the figure, that is, in the thickness direction of the temperature control plate 310, the first flow channel 313 and the second flow channel 314 are arranged up and down, specifically, the first flow channel 313 is located above the second flow channel 314. In this embodiment, although the heat exchange efficiency between the first medium and the second medium can be higher, the thickness of the temperature control plate 310 will be increased to a certain extent, and then the thickness of the temperature control plate assembly 300 will be increased, so that the temperature control plate assembly 300 occupies more space in the storage chamber 110.

[0071] In the embodiment where the first flow channel 313 and the second flow channel 314 are arranged vertically, the second flow channel 314 may be a groove arranged on the temperature control plate 310, or a through hole arranged in the temperature control plate 310, or a lumen of the liquid delivery pipe 360 ​​in contact with and connected to the temperature control plate 310. Figure 8 and Fig. 9 As shown, the second flow channel 314 may be located directly below the first flow channel 313; in other embodiments, such as Fig.12 As shown, the second flow channel 314 may also be located obliquely below the first flow channel 313 .

[0072] In the embodiment where the second flow channel 314 is a groove disposed on the temperature control plate 310, Figure 8 and Fig. 9 and Fig.12 As shown, the temperature control plate 310 has a second surface 312 opposite to the first surface 311. Since the first flow channel 313 is not connected to the second flow channel 314, the second flow channel 314 can be arranged on the second surface 312. When the biological sample storage system works normally, the second surface 312 of the temperature control plate 310 is located below the first surface 311, and a part of the second surface 312 is recessed upward to form the second flow channel 314. It is not difficult to understand that the second flow channel 314 is also recessed toward the inside of the temperature control plate 310.

[0073] Furthermore, a heat insulation board 370 is provided on the side of the temperature control board 310 away from the temperature balancing board 320. The heat insulation board 370 can block the transfer of cold or heat, and can make the temperature of the medium entering the first flow channel 313 be derived from the side of the temperature balancing board 320, so that the temperature in the temperature balancing board 320 can be quickly and evenly distributed, and at the same time, the problem of temperature cross-contamination on the side of the temperature control board assembly 300 away from the heat conducting board 330 can be avoided. It is not difficult to understand that the heat insulation board 370 is made of a material with good heat insulation performance.

[0074] Furthermore, in the embodiment where the second flow channel 314 is formed by the second surface 312 being recessed upward, a second sealing plate 342 is further provided on the side of the temperature control plate 310 facing away from the first surface 311, and the second sealing plate 342 is in surface contact with the second surface 312 of the temperature control plate 310 to close the circumference of the second flow channel 314. The second sealing plate 342 closes the circumference of the second flow channel 314, which means that in a cross section of the second flow channel 314 perpendicular to its own extension direction, the contour of the cross section is a closed figure, and the contour line of the cross section is partially derived from the second sealing plate 342; Fig. 9 and Fig.12 As shown, in the cross section perpendicular to the extension direction of the second flow channel 314, part of the contour line comes from the temperature control plate 310, and the other part of the contour line comes from the second sealing plate 342. In this embodiment, there is no special restriction on the structure of the second sealing plate 342, as long as it has a plane that can contact the second surface 312 to cover the second flow channel 314. The second sealing plate 342 and the temperature control plate 310 can be connected by threaded fasteners or by other connection methods. Furthermore, in this embodiment, the second sealing plate 342 can be made of a material with heat insulation properties, that is, the second sealing plate 342 can be used as a heat insulation plate 370.

[0075] Of course, the second flow channel 314 can also be arranged on other side surfaces of the temperature control plate 310 other than the first surface 311. In these embodiments, correspondingly, the second sealing plate 342 is also arranged on the corresponding side surface to close the circumference of the second flow channel 314. The second flow channel 314 can be arranged at a position that can prevent the first flow channel 313 and the second flow channel 314 from being connected.

[0076] The above-mentioned embodiment of recessing the surface of the temperature control plate 310 inward to form the second flow channel 314 and using the second sealing plate 342 to seal the circumference of the second flow channel 314 has the advantage of being easy to process and shape the second flow channel 314 on the temperature control plate 310 .

[0077] In the embodiment in which the first flow channel 313 and the second flow channel 314 are arranged up and down, the second flow channel 314 may also be a through hole arranged in the temperature control plate 310. In the embodiment in which the first flow channel 313 and the second flow channel 314 are arranged up and down, the first flow channel 313 and the second flow channel 314 may also extend along an S-shaped trajectory, and the orthographic projections of the first flow channel 313 and the second flow channel 314 on the first surface 311 may be parallel to each other, may overlap with each other, or may intersect. Similarly, in the embodiment in which the first flow channel 313 and the second flow channel 314 are arranged up and down, the number of the first flow channel 313 and the second flow channel 314 may be multiple, and the first flow channel 313 and the second flow channel 314 may extend along a straight line trajectory. Further, the first flow channel 313 and the second flow channel 314 are parallel to each other and arranged alternately; the orthographic projections of the first flow channel 313 and the second flow channel 314 on the first surface 311 may be parallel to each other or overlap with each other.

[0078] In the embodiment where the first flow channel 313 and the second flow channel 314 are arranged in different layers (i.e., layered arrangement), in order to reduce the thickness of the temperature control plate 310 to a certain extent and to make the temperature control efficiency of the heat conducting plate 330 by the second medium higher to a certain extent, in some embodiments, Fig.12 As shown, the orthographic projections of the first flow channel 313 and the second flow channel 314 on the vertically extending plane of the temperature control plate 310 partially overlap (that is, the orthographic projections of the first flow channel 313 and the second flow channel 314 on the side of the temperature control plate 310 partially overlap); further, the orthographic projections of the first flow channel 313 and the second flow channel 314 on the first surface 311 may not overlap. Figure 8 , Fig. 9 , Fig.12 , Fig.13 It is not difficult to see that the first surface 311 of the temperature control plate 310 is the upward side of the temperature control plate 310 when the temperature control plate assembly 300 is in the working state, and the second surface 312 is the downward side of the temperature control plate 310 when the temperature control plate assembly 300 is in the working state; the vertically extending plane of the temperature control plate 310 is the side of the temperature control plate 310. When the depths of the first flow channel 313 and the second flow channel 314 are fixed, since the orthographic projections of the first flow channel 313 and the second flow channel 314 of the temperature control plate 310 on the first surface 311 do not overlap, that is, the first flow channel 313 and the second flow channel 314 are alternately arranged in the horizontal direction, the purpose of reducing the thickness of the temperature control plate 310 can be achieved; at the same time, since the thickness of the temperature control plate 310 is relatively small, and the first flow channel 313 and the second flow channel 314 are arranged in different layers, the second flow channel 314 is closer to the heat conducting plate 330, so the second medium will also affect the temperature of the heat conducting plate 330 to a certain extent, thereby improving the efficiency of temperature regulation of the heat conducting plate 330.

[0079] Based on the above content Fig.10 and Fig.12 It is not difficult to know that in the implementation manner where the first flow channel 313 and the second flow channel 314 are arranged in the same layer or up and down, the first flow channel 313 and the second flow channel 314 can be arranged alternately in the horizontal direction.

[0080] According to the above scheme, it is not difficult to see that in the embodiment where the first flow channel 313 and the second flow channel 314 are arranged in the same layer or up and down, the second flow channel 314 can be the lumen of the liquid delivery pipe 360 ​​that is in contact with the temperature control plate 310. The contact connection between the liquid delivery pipe 360 ​​and the temperature control plate 310 means that there is direct contact between the liquid delivery pipe 360 ​​and the temperature control plate 310, including connection by means of clamping, threaded fastener connection, etc. that meet this condition.

[0081] In the implementation of the present application, there is no limitation on the form of the second flow channel 314. Fig.12 In the embodiment shown, the second flow channel 314 is a groove-shaped structure disposed on the temperature control plate 310; Fig.13 In the illustrated embodiment, the second flow channel 314 is a through hole provided in the temperature control plate 310. Fig.14 In the illustrated embodiment, the second flow channel 314 may also be a lumen of a liquid delivery pipe 360 ​​disposed on the temperature control plate 310 . It is easy to understand that the liquid delivery pipe 360 ​​is also a heat-conducting structural component so that the second medium can achieve heat exchange with the temperature control plate 310 .

[0082] The liquid delivery pipe 360 ​​is in contact with the temperature control plate 310 so that the second medium can exchange heat with the temperature control plate 310. Furthermore, in order to increase the contact area between the liquid delivery pipe 360 ​​and the temperature control plate 310 to improve the heat exchange efficiency between the second medium and the temperature control plate 310, in some embodiments, a square pipe can be used as the liquid delivery pipe 360 ​​so that the square pipe is in surface contact with the temperature control plate 310.

[0083] In other embodiments, the liquid delivery pipe 360 ​​may also be a circular pipe. In one embodiment, a groove having an arc-shaped cross section corresponding to the circular pipe is provided on the temperature control plate 310 so that the liquid delivery pipe 360 ​​and the temperature control plate 310 are in surface contact. Furthermore, the cross-sectional size of the arc-shaped groove matches the outer diameter of the liquid delivery pipe 360. Fig.14 In the illustrated embodiment, a through hole with a circular cross section is provided on the temperature control plate 310 , and the liquid delivery pipeline 360 ​​is provided in the circular through hole, and the diameter of the through hole matches the outer diameter of the liquid delivery pipeline 360 ​​.

[0084] In some embodiments of the present application, the edge of the temperature control plate 310 has a protrusion 350 protruding from the first surface 311, and the protrusion 350 is arranged around the outer periphery of the temperature averaging plate 320. It is not difficult to understand that the protrusion 350 is arranged around the circumference of the temperature control plate 310 and forms an annular structure, and the temperature averaging plate 320 is arranged in the annular structure, and the inner surface of the protrusion 350 and the first surface 311 of the temperature control plate 310 form a groove for accommodating the temperature averaging plate 320.

[0085] In some embodiments, the heat conducting plate 330 is also located inside the annular structure surrounded by the protrusions 350, that is, Figure 5 The protrusion 350 shown is arranged around the periphery of the heat conducting plate 330. Furthermore, the protrusion 350 is sealed and connected to the periphery of the heat conducting plate 330, so that the heat conducting plate 330, the protrusion 350 and the temperature control plate 310 form a chamber capable of accommodating the temperature plate 320. Of course, in other embodiments, such as Figure 6 As shown, the heat conducting plate 330 may also be covered on the top of the protrusion 350, and the top of the protrusion 350 is sealed and connected to the heat conducting plate 330. In other embodiments, the heat conducting plate 330 may also have a part of its surface in contact with the inner surface of the annular structure surrounded by the protrusion 350, and another part of its surface in contact with the top surface of the protrusion 350.

[0086] Furthermore, the temperature control board 310 is also connected to a first liquid inlet joint and a first liquid outlet joint. The first liquid inlet joint is connected to one end of the first flow channel 313, and the first liquid outlet joint is connected to the other end of the first flow channel 313. The first liquid inlet joint and the first liquid outlet joint can be connected to an external pipeline to transport the first medium into the first flow channel 313. In some embodiments, the external pipeline can pass through the shell 100 from the outside of the shell 100 and then enter the storage chamber 110, and then communicate with the first flow channel 313; the position where the external pipeline passes through the shell 100 is heat-insulated and sealed.

[0087] In some embodiments, the temperature control plate 310 is further connected to a second liquid inlet joint and a second liquid outlet joint. The second liquid inlet joint is connected to one end of the second flow channel 314, and the second liquid outlet joint is connected to the other end of the second flow channel 314. The second liquid inlet joint and the second liquid outlet joint can be connected to an external pipeline to realize the delivery of the second medium into the second flow channel 314.

[0088] The temperature equalizing plate 320 provided in the present application has the effect of uniform temperature distribution. According to the different temperatures of the first medium introduced therein, the temperature equalizing plate 320 provided in the present application can be used in different fields, for example, it can also be used in the technical field of uniformly heating objects.

[0089] Further, in some embodiments of the present application, Figure 4 , Fig.17 and Fig.18As shown, the biological sample storage system also includes a sampling door plate 200, which is connected to the shell 100 and in contact with the storage chamber 110, that is, the structure surrounding the storage chamber 110 includes the inner side of the shell 100 and the surface of the sampling door plate 200 facing the storage chamber 110.

[0090] like Fig.17 and Fig.18 As shown, the sampling door plate 200 includes a plate body 210 and a transfer device 220 disposed on the plate body 210, wherein the plate body 210 is connected to the housing 100, and the transfer device 220 has an open state and a closed state, that is, the state of the transfer device 220 can be changed. When the transfer device 220 is in the open state, it has a sampling channel connecting one side of the plate body 210 with the other side of the plate body 210, that is, when the transfer device 220 is in the open state, the storage chamber 110 and the atmospheric environment are connected to each other through the sampling channel. When the transfer device 220 is in the closed state, the space on both sides of the plate body 210 is separated at the position of the transfer device 220.

[0091] The spaces on both sides of the plate body 210 are separated at the position of the transfer device 220, which may mean that the spaces on both sides are completely isolated, or that the transfer device 220 has a greater blocking effect on the gas exchange between the spaces on both sides, but a small amount of gas exchange can still exist in the spaces on both sides of the transfer device 220, that is, when the transfer device 220 is in a closed state, the storage chamber 110 and the atmospheric environment can be completely isolated, or that a small amount of gas exchange can still exist between the storage chamber 110 and the atmospheric environment.

[0092] During the sampling operation, sampling is performed through the sampling channel of the transfer device 220 on the sampling door panel 200 in the open state, rather than opening the sampling door panel 200 for sampling. Therefore, when sampling is performed, the channel connecting the storage chamber 110 and the atmospheric environment is smaller, which can effectively reduce the ambient gas containing water vapor in the atmospheric environment from entering the storage chamber 110, thereby reducing the amount of frost in the storage chamber 110 and improving the frost condition in the storage chamber 110.

[0093] It should not be difficult for technicians in this field to understand that a through hole or a notch should be provided on the plate body 210, and the transfer device 220 should be installed at the position of the through hole or the notch, so that the transfer device 220 can connect the two sides of the plate body 210 through the channel when it is in the open state; when the transfer device 220 is in the closed state, the through hole or the notch on the plate body 210 is completely covered.

[0094] In some embodiments of the present application, the transfer device 220 is in a normally closed state when no external force is applied. The normally closed state means that it is always in a closed state. That is, when no external force is applied, the transfer device 220 can always remain in a closed state; during the sampling process, the transfer device 220 can be passively opened and automatically closed when the sampling process ends.

[0095] Among them, external force refers to the force applied by the structure outside the biological sample storage system provided by the present application, and external force does not include gravity; passive opening means that the transfer device 220 becomes an open state under the action of external force; automatic closing means that the transfer device 220 automatically returns to a closed state after the external force is removed. It is not difficult to understand that the sampling device used for sampling can extend from one side of the plate body 210 through the transfer device 220 to the other side of the plate body 210. During the process of the sampling device extending into the transfer device 220, the sampling device contacts the transfer device 220 and applies a force to the transfer device 220, so that the transfer device 220 passively changes to an open state; after the sampling device takes out the sample through the sampling channel of the transfer device 220, the transfer device 220 actively changes to a closed state. Among them, the sampling device can be a manipulator 500 in the automatic sampling process, or it can be the arm of an operator in manual sampling.

[0096] Of course, in some other implementations, the transmission device 220 may be in a normally closed state by the action of an external force. In the implementation of using an external force to keep the transmission device 220 in a normally closed state, it is necessary to provide a force-applying device for applying an external force to the transmission device 220, and increase the structure of the sampling door plate 200, but to a certain extent, the transmission device 220 can be maintained in a normally closed state more stably.

[0097] In one embodiment, the transfer device 220 is in a normally closed state without external force. Fig.19 and Fig. 20 As shown, the transfer device 220 includes at least one layer of elastic diaphragm 221, and each layer of diaphragm 221 includes a plurality of elastic parts 2211 arranged along the circumference. The elastic parts 2211 are fan-shaped, that is, the elastic parts 2211 are arc-shaped pieces. It is not difficult to understand that the elastic parts 2211 are also elastic and can be elastically deformed. The elastic parts 2211 of the same layer can be assembled into a circle along the circumference. There are seams between the elastic parts 2211. When the elastic parts 2211 are not subjected to external forces, the edges of the two adjacent elastic parts 2211 contact each other, and the size of the seams between the elastic parts 2211 is almost zero, so that the space on both sides of the diaphragm 221 is connected without the diaphragm 221. At this time, the transfer device 220 is in a closed state, and the space on both sides of the plate body 210 is separated at the position of the transfer device 220.

[0098] When the elastic part 2211 is held by the sampling device, the elastic part 2211 will be deformed, and the edges of the two adjacent elastic parts 2211 will separate from each other, so that the transfer device 220 is in an open state. After the sampling device completes sampling, the force applied by the sampling device to the elastic part 2211 disappears, the elastic part 2211 in the diaphragm 221 is reset under the action of its own elasticity, and the transfer device 220 automatically changes to a closed state. In some embodiments, the elastic part 2211 can be a silicone material structure, a silicone rubber material structure, and a rubber material structure, such as natural rubber, butadiene rubber, styrene-butadiene rubber, propylene rubber, etc., and technicians in this field can select according to the actual application scenario.

[0099] Of course, in other embodiments, the transfer device 220 may also include two or more layers of diaphragms 221, on which basis, the seams between the elastic parts 2211 in two adjacent layers of diaphragms 221 are staggered. In other embodiments, the diaphragm 221 may also be a rectangle or other polygon, and the elastic part 2211 may also be a triangle, rectangle, etc.; in the embodiments where the diaphragm 221 is other polygons, the diaphragm 221 is preferably a regular polygon with 5 to 10 sides.

[0100] In some embodiments, Fig.19 As shown, the diaphragm 221 may be formed by splicing only the elastic parts 2211; in other embodiments, such as Fig. 20 As shown, the diaphragm 221 further includes a connecting ring 2212, the connecting ring 2212 is annular, and the elastic part 2211 is connected to the inner side of the connecting ring 2212. Furthermore, the connecting ring 2212 and the elastic part 2211 are integrally formed and connected. Fig. 20 The middle dotted line is the boundary between the elastic portion 2211 and the connecting ring 2212 .

[0101] Furthermore, the diameter of the sampling channel is not less than 10 cm, so as to facilitate the removal of the sample from the sampling channel. Among them, the diameter of the sampling channel is not less than 10 cm, which is the maximum diameter that the sampling channel can reach when the diaphragm 221 is not damaged; when the sampling channel is not circular, the diameter of the sampling channel is not less than 10 cm, which means that the diameter of the circumscribed circle of the sampling channel is not less than 10 cm. It is not difficult to understand that the smaller the diameter of the sampling channel, the less the amount of ambient gas containing water vapor that can enter the storage chamber 110 during sampling, and the more obvious the improvement effect on the frosting problem. In the case where the diaphragm 221 is a circular structural member, the diameter of the diaphragm 221 is 12 to 20 cm accordingly.

[0102] In other embodiments, the automatic opening and closing of the transfer device 220 during the sampling process may also be achieved by automatic control. For example, a sensor is used to monitor whether a sampling device is close to the transfer device 220. When the sampling device is close to the transfer device 220, the transfer device 220 is automatically opened to form a sampling channel through a signal control. After the sampling device completes sampling, the transfer device 220 is automatically closed through a signal control. The specific implementation method is similar to that of an existing automatic door.

[0103] In an embodiment of the present application, there may be multiple transfer devices 220, and the multiple transfer devices 220 are distributed on the plate 210 according to a preset rule, such as a matrix distribution, so as to facilitate the retrieval and placement of samples at multiple locations in the storage chamber 110.

[0104] In some embodiments of the present application, in order to facilitate observation of the sample box in the storage chamber 110 through the sampling door plate 200, so as to facilitate the transfer device 220 to take samples from the storage chamber 110, the plate body 210 includes a transparent structural member, and the transparent structural member can realize observation of the situation on the other side of the plate body 210 from one side of the plate body 210. For example, in one embodiment, the transparent structural member can be an acrylic plate; in another embodiment, the transparent structural member can be glass.

[0105] Since the sampling door plate 200 is in direct contact with the storage chamber 110, and the storage chamber 110 needs to maintain a relatively low temperature to store biological samples, the sampling door plate 200 also has a certain heat insulation function to reduce the amount of cold that is lost from the storage chamber 110 to the atmosphere through the sampling door plate 200.

[0106] Furthermore, in some embodiments, in order to improve the thermal insulation performance of the sampling door plate 200 and reduce the heat exchange between the storage chamber 110 and the atmospheric environment, the plate body 210 is a multi-layer structure, and the plate body 210 includes a thermal insulation layer 213 .

[0107] like Fig.18As shown, the plate body 210 includes a first transparent material layer 211, a second transparent material layer 212, and a transparent heat-insulating layer 213 located between the first transparent material layer 211 and the second transparent material layer 212. It is not difficult to understand that the first transparent material layer 211, the second transparent material layer 212, and the heat-insulating layer 213 are all transparent, which can facilitate observation from one side of the plate body 210 to the other side. Among them, the first transparent material layer 211 and the second transparent material layer 212 can be made of acrylic, glass or other existing transparent materials; the first transparent material layer 211, the second transparent material layer 212, and the heat-insulating layer 213 can also be transparent but colored structural parts. The materials of the first transparent material layer 211 and the second transparent material layer 212 can be made of the same material or different materials. The first transparent material layer 211 and the second transparent material layer 212 are both plate-shaped structural parts, and the surface with the largest area in the first transparent material layer 211 is arranged opposite to the surface with the largest area in the second transparent material layer 212. The surface with the largest area in the first transparent material layer 211 is the same size or close to the surface with the largest area in the second transparent material layer 212. Since the sampling channel can connect the spaces on both sides of the plate body 210, it is not difficult to understand that in this embodiment, the sampling channel can also pass through the first transparent material layer 211, the heat insulation layer 213 and the second transparent material layer 212.

[0108] The sampling door panel 200 is applied to the biological sample storage system provided in the present application. One of the first transparent material layer 211 and the second transparent material layer 212 is in contact with the storage chamber 110, and the other is arranged toward the atmospheric environment. The heat transfer between the first transparent material layer 211 and the second transparent material layer 212 can be reduced by the thermal insulation layer 213, thereby reducing the amount of cold that is dissipated from the storage chamber 110 to the atmospheric environment through the sampling door panel 200.

[0109] In some embodiments, the heat insulating layer 213 may be a vacuum layer formed between the first transparent material layer 211 and the second transparent material layer 212, that is, the cavity between the first transparent material layer 211 and the second transparent material layer 212 is a vacuum environment to reduce heat transfer between the first transparent material layer 211 and the second transparent material layer 212, thereby reducing heat exchange between the storage chamber 110 and the atmospheric environment. The vacuum layer may be formed only by the first transparent material layer 211 and the second transparent material layer 212, or may be formed by the first transparent material layer 211, the second transparent material layer 212, and a square frame arranged along the edges of the first transparent material layer 211 and the second transparent material layer 212.

[0110] In other embodiments, the thermal insulation layer 213 may also be formed of a liquid, gaseous or solid structure, such as existing products such as thermal insulation cotton with a low thermal conductivity.

[0111] Furthermore, in order to ensure that the thermal insulation layer 213 has a better thermal insulation effect, in the above embodiment, the surface size with the largest area in the thermal insulation layer 213 is close to the first transparent material layer 211 and the second transparent material layer 212, so as to reduce the relative contact area between the first transparent material layer 211 and the second transparent material layer 212, thereby reducing the heat transfer between the first transparent material layer 211 and the second transparent material layer 212.

[0112] In some embodiments, the plate body 210 further includes a third transparent material layer to further reduce the amount of cold that is lost from the storage chamber 110 to the atmosphere through the sampling door plate 200. For example, in some other embodiments, a third transparent material layer is further provided between the first transparent material layer 211 and the second transparent material layer. The aforementioned heat insulation layer 213 includes a first sub-heat insulation layer 213 located between the first transparent material layer 211 and the third transparent material layer, and a second sub-heat insulation layer 213 located between the second transparent material layer 212 and the third transparent material layer.

[0113] In the biological sample storage system provided by the present application, the situation inside the storage chamber 110 can be observed through the sampling door panel 200; because during the sampling process, one side of the sampling door panel 200 is in contact with the atmospheric environment and the other side is in contact with the storage chamber 110, the temperature on the side of the sampling door panel 200 facing the atmospheric environment is lower. Therefore, frost will appear on the surface of the sampling door panel 200 in contact with the atmospheric environment, making it inconvenient to observe the storage chamber 110 during the sampling process.

[0114] Further, in some embodiments, Figure 1 As shown, the biological sample storage system also includes a heat preservation door 400, which is arranged on the side of the sampling door plate 200 facing away from the storage chamber 110. The heat preservation door 400 is used to cover the sampling door plate 200. When the heat preservation door 400 is opened, the sampling door plate 200 is in contact with the atmospheric environment; when the heat preservation door 400 is closed, the heat preservation door 400 separates the sampling door plate 200 from the atmospheric environment. Since the storage temperature of the biological sample is low, the sampling door plate 200 is in contact with the storage chamber 110, so the sampling door plate 200 also has a lower temperature. By setting the heat preservation door 400 to separate the sampling door plate 200 from the atmospheric environment, the condensation phenomenon on the sampling door plate 200 can be reduced. The biological sample storage system provided in this embodiment can be used in the scene of manual sampling, that is, after the sampling personnel opens the heat preservation door 400, they put their hands into the storage chamber 110 through the transfer device 220, and then take out the sample in the storage chamber 110.

[0115] In other embodiments, the housing 100 further includes an operating room 120, and the operating room 120 is selectively connected to the storage room 110. The selective connection between the operating room 120 and the storage room 110 means that the operating room 120 and the storage room 110 can be switched between connection and disconnection, for example, an openable automatic door can be provided between the operating room 120 and the storage room 110, and the connection and disconnection between the operating room 120 and the storage room 110 can be achieved by opening and closing the automatic door. For those skilled in the art, the automatic door and the hardware and software for controlling the opening and closing of the automatic door are already existing technologies and will not be described in detail here.

[0116] The operation chamber 120 is provided with a sampling device, namely, a manipulator 500, which is used to transfer the sample in the storage chamber 110 to the operation chamber 120, and to send the sample in the operation chamber 120 out of the operation chamber 120 through the transfer device 220 of the sampling door panel 200. The sampling process can be automatically realized by the manipulator 500, and because the operation chamber 120 is provided, the frosting process will mainly occur in the operation chamber 120, thereby reducing the frosting phenomenon in the storage chamber 110.

[0117] Furthermore, the sampling door plate 200 is disposed on the side of the operating chamber 120 facing away from the storage chamber 110 and in contact with the operating chamber 120; the sampling door plate 200 is connected to the housing 100 but does not contact with the storage chamber 110; the operating chamber 120 and the storage chamber 110 are separated by other structures. Figure 2 As shown, the sample taken from the storage chamber 110 to the operation chamber 120 by the robot 500 can be sent out of the operation chamber 120 through the transfer device 220 on the sampling door panel 200 .

[0118] Of course, in some other embodiments, the sampling door plate 200 may be in contact with both the storage chamber 110 and the operating chamber 120, for example, the storage chamber 110 and the operating chamber 120 are separated by the sampling door plate 200, and the storage chamber 110 and the operating chamber 120 are connected by the transmission device 220 in the open state. The sampling door plate 200 may not be provided in the operating chamber 120, and this application does not limit this.

[0119] Alternatively, in other embodiments, the sampling door panel 200 may not be provided in the operating chamber 120 , and the biological sample may be directly taken from the storage chamber 110 to the operating chamber 120 by the manipulator 500 , and then the biological sample may be sent out of the operating chamber 120 by the manipulator 500 .

[0120] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A temperature control panel assembly, characterized in that: include: A temperature control plate, wherein a first flow channel for passing a first medium is provided in the temperature control plate; A temperature averaging plate, the temperature averaging plate having three-dimensional through micro-holes, the temperature averaging plate cover being arranged on the temperature control plate; A heat conducting plate is covered on a side of the temperature averaging plate away from the temperature control plate.

2. The temperature control panel assembly according to claim 1, characterized in that: The temperature equalizing plate is a foam metal structural component.

3. The temperature control panel assembly according to claim 1, characterized in that: The ratio of the thickness of the temperature equalizing plate to the thickness of the temperature control plate assembly is 1:(2-8).

4. The temperature control panel assembly according to claim 3, characterized in that: The thickness of the temperature control plate assembly is in the range of 35 to 50 mm; the thickness of the temperature equalizing plate is in the range of 5 to 15 mm.

5. The temperature control panel assembly according to claim 1, characterized in that: The temperature equalizing plate is in surface contact with the heat conducting plate and the temperature control plate.

6. The temperature control panel assembly according to any one of claims 1 to 5, characterized in that: A heat insulation plate is arranged on one side of the temperature control plate away from the temperature uniformity plate.

7. The temperature control panel assembly according to claim 6, characterized in that: The temperature control plate is also provided with a second flow channel which is not interconnected with the first flow channel and is used to introduce a second medium, and the second medium can perform heat exchange with the first medium.

8. The temperature control panel assembly according to claim 7, characterized in that: The temperature control plate is a heat-conducting structural component, and the first flow channel and the second flow channel are arranged in the same layer.

9. The temperature control panel assembly according to claim 8, characterized in that: The first flow channel and the second flow channel are both S-shaped.

10. The temperature control panel assembly according to claim 7, characterized in that: The temperature control plate is a heat-conducting structural component. The first flow channel and the second flow channel are arranged in layers. The second flow channel is located on a side of the first flow channel away from the temperature homogenizing plate.

11. The temperature control panel assembly according to claim 10, characterized in that: The temperature control plate has a first surface and a second surface opposite to each other, a portion of the first surface is recessed downward to form the first flow channel, and a first sealing plate for sealing the first flow channel is provided between the first surface and the temperature homogenizing plate; A partial area of ​​the second surface is recessed upward to form the second flow channel, and a second sealing plate for closing the second flow channel is arranged between the second surface and the heat insulation plate.

12. The temperature control panel assembly according to claim 11, characterized in that: The orthographic projections of the first flow channel and the second flow channel on the first surface of the temperature control plate do not overlap, and the orthographic projections of the first flow channel and the second flow channel on the side surface of the temperature control plate partially overlap.

13. The temperature control panel assembly according to any one of claims 1 to 5, characterized in that: The heat conducting plate is a copper structural part, a stainless steel structural part, or an aluminum structural part.

14. The temperature control panel assembly according to any one of claims 1 to 5, characterized in that: The edge of the temperature control plate has a bulge protruding from the first surface, and the bulge is arranged around the outer periphery of the temperature uniform plate.

15. The temperature control panel assembly according to claim 14, characterized in that: The protrusions are arranged around the circumference of the temperature control plate, and the protrusions are also arranged around the outer circumference of the heat conducting plate and connected to the outer circumference of the heat conducting plate.

16. The temperature control panel assembly according to claim 14, characterized in that: The protrusion is arranged around the circumference of the temperature control plate, the heat conducting plate is covered on the protrusion, and the edge of the heat conducting plate is connected to the protrusion.

17. A biological sample storage system, characterized in that: It comprises a shell and a temperature control plate assembly as described in any one of claims 1 to 16, wherein the temperature control plate assembly is a refrigeration plate assembly, the first medium in the first flow channel is a refrigeration medium, the shell comprises a storage chamber for placing samples, the refrigeration plate assembly is arranged in the storage chamber, the heat conduction plate is located at the top, the temperature control plate is located at the bottom, and the surface of the heat conduction plate away from the temperature control plate is used for placing samples.

18. The biological sample storage system according to claim 17, characterized in that: A plurality of the refrigeration panel assemblies are disposed in the storage chamber, and the plurality of the refrigeration panel assemblies are arranged at intervals in a vertical direction.

19. The biological sample storage system according to claim 17, characterized in that: It also includes a sampling door plate, which is arranged on the shell; the sampling door plate includes a plate body and a transfer device arranged on the plate body; the transfer device has an open state and a closed state, and the transfer device has a sampling channel connecting one side of the plate body with the other side of the plate body when in the open state; when the transfer device is in a closed state, the space on both sides of the plate body is separated at the position of the transfer device.

20. The biological sample storage system according to claim 19, characterized in that: The plate body at least includes a first transparent material layer, a second transparent material layer, and a transparent heat insulation layer located between the first transparent material layer and the second transparent material layer.

21. The biological sample storage system according to claim 20, characterized in that: The transfer device is configured as follows: a sampling device can extend from one side of the plate body through the transfer device to the other side of the plate body; during the process of the sampling device extending into the transfer device, the transfer device passively changes to an open state; after the sampling device takes out the sample, the transfer device actively changes to a closed state.

22. The biological sample storage system according to claim 21, characterized in that: The transfer device includes at least one layer of elastic diaphragm, and each layer of the diaphragm includes a plurality of elastic parts arranged along the circumferential direction. When the elastic part is supported by the sampling device, the elastic part is deformed to put the transfer device in an open state; when the elastic part is reset, the transfer device is in a closed state.

23. The biological sample storage system according to any one of claims 19 to 22, characterized in that: The shell also includes an operating chamber for sampling, and the operating chamber is selectively connected to the storage chamber. The sampling door plate is arranged in the operating chamber. A manipulator is arranged in the operating chamber, and the manipulator is used to transfer the sample in the storage chamber to the operating chamber, and send the sample in the operating chamber out of the operating chamber through the transfer device of the sampling door plate.

24. The biological sample storage system according to claim 23, characterized in that: It also includes a heat-insulating door, which covers the sampling door plate; when the heat-insulating door is opened, the sampling door plate is in contact with the atmospheric environment; when the heat-insulating door is closed, the heat-insulating door separates the sampling door plate from the atmospheric environment.

25. The biological sample storage system according to claim 17 or 18, characterized in that: The shell also includes an operation chamber for sampling, and the operation chamber is selectively connected to the storage chamber. A manipulator is provided in the operation chamber, and the manipulator is used to transfer samples in the storage chamber to the operation chamber, and to send samples in the operation chamber out of the operation chamber.

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