Cooling device used in stem cell cryopreservation process

Abstract

The utility model relates to the technical field of stem cell cooling, in particular to a cooling device used in the stem cell cryopreservation process, which comprises a storage barrel and further comprises a water tank arranged on the surface of the storage barrel, a water outlet formed in the surface of the water tank, a first groove formed in the surface of the storage barrel and a vent hole formed in the surface of the storage barrel. The rubber cover is arranged on the surface of the first groove, the barometer is arranged on the surface of the storage barrel, the first groove is formed in the surface of the storage barrel, the first bearing plate is arranged on the surface of the storage barrel, the connecting blocks are arranged on the surface of the first bearing plate, and the connecting rods are arranged on the surfaces of the connecting blocks. The sliding blocks are arranged on the surface of the first bearing plate, the first motor is arranged on the surface of the first bearing plate, and the second bearing plate is arranged on the surface of the first motor, so that the stem cells and the cryopreservation liquid can be mixed more uniformly, the survival time of the stem cells is prolonged, and a worker can store the stem cells conveniently.

Description

Technical Field

[0001] The utility model relates to the technical field of stem cell cooling, in particular to a cooling device used in the process of stem cell freezing. Background Art

[0002] As we all know, stem cell preservation is a process of freezing stem cells in order to preserve their activity and potential for a long time. Stem cells are a type of primitive cells with self-renewal ability and multidirectional differentiation potential. They can differentiate into various types of cells or tissues and organs. The preservation of stem cells usually involves special cryopreservation techniques, which include the use of liquid nitrogen to keep stem cells in a dormant state. The life activities in the cells are almost stopped, so that the long-term preservation of stem cells can be achieved. Current technology shows that stem cells can be preserved for a long time, even more than a century, and the preserved stem cells still have activity and potential for clinical application.

[0003] After searching, the utility model patent with Chinese publication number CN208940797U discloses a cooling device used in the process of stem cell cryopreservation, which includes a heat-insulating outer shell, a protective shell, and a fixed frame. A heat exchange pipe is arranged on the inner side of the heat-insulating outer shell, and a heat-conducting inner shell is arranged on the side of the heat-exchange pipe away from the heat-insulating outer shell. The fixed frame is arranged inside the heat-conducting inner shell, and a fixing plate is arranged inside the fixed frame. A fixing through hole is arranged on the fixing plate, and a protective pad is arranged below the fixing plate. An elastic heat-insulating block is arranged above the fixed frame, and a rotating shaft is arranged below the fixed frame. A supporting slider is arranged on the side of the rotating shaft, and a temperature sensor is arranged between the supporting slider and the rotating shaft. The beneficial effect is that the utility model can automatically drive the fixed frame to rotate, thereby rotating the stem cell container in the fixed frame, so that the stem cells and the freezing solution are evenly mixed. It is simple and convenient to use, and the mixing effect is improved.

[0004] In the above technical solution, the container storing stem cells can only be rotated in place, but the container cannot be rotated backwards, which may cause the stem cells and the freezing solution to be unevenly mixed, resulting in a significant reduction in the storage time of the stem cells and causing great inconvenience to the staff during storage. Therefore, a cooling device is needed for use in the freezing process of stem cells. Utility Model Content

[0005] 1. Technical issues to be solved

[0006] In view of the deficiencies of the prior art, the utility model provides a cooling device used in the cryopreservation process of stem cells to solve the problems raised in the above background technology.

[0007] (II) Technical solution

[0008] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a cooling device used in the process of freezing stem cells, comprising a storage barrel, and also comprising

[0009] A water tank, the water tank being arranged on the surface of the storage barrel;

[0010] A water outlet, wherein the water outlet is provided on the surface of the water tank;

[0011] A first groove, wherein the first groove is formed on the surface of the storage barrel;

[0012] A vent hole, wherein the vent hole is provided on the surface of the storage barrel;

[0013] a rubber cover, the rubber cover being disposed on a surface of the first groove;

[0014] A barometer is provided on the surface of the storage barrel.

[0015] Preferably, the first chute, the first groove is opened on the surface of the storage barrel;

[0016] a first carrying plate, the first carrying plate being arranged on a surface of the storage barrel;

[0017] A plurality of connection blocks, each of which is arranged on the surface of the first carrying plate;

[0018] A plurality of connecting rods, each of which is arranged on a surface of the connecting block;

[0019] Two sliders, each of which is arranged on the surface of the first carrying plate.

[0020] Further, a first motor, wherein the first motor is arranged on a surface of a first bearing plate;

[0021] A first square tube, the first square tube being arranged on a surface of an output end of the first motor;

[0022] A fixed shaft, the fixed shaft being arranged on the surface of the first square tube;

[0023] a first bearing disposed on a surface of the fixed shaft;

[0024] a second bearing plate, the second bearing plate being disposed on a surface of the first bearing;

[0025] a second slide groove, wherein the second slide groove is provided on the surface of the second carrying plate;

[0026] A telescopic rod, wherein the telescopic rod is arranged on the surface of the first square tube;

[0027] Two support columns, each of which is arranged on the surface of the second supporting plate.

[0028] Still further, a load-bearing rod, wherein the load-bearing rod is arranged on the surface of the telescopic rod;

[0029] a second motor, the second motor being disposed on the surface of the bearing rod;

[0030] a third bearing plate, the third bearing plate being arranged on a surface of an output end of the second motor;

[0031] A plurality of second grooves, each of which is disposed on the surface of the third supporting plate;

[0032] A plurality of supporting tubes are provided, each of the supporting tubes being arranged on a surface of a corresponding second groove.

[0033] A further solution is a lifting frame, wherein the lifting frame is arranged on the surface of the connecting block;

[0034] A fixing block, wherein the fixing block is arranged on the surface of the storage barrel;

[0035] a second bearing, the second bearing being disposed on a surface of the fixed block;

[0036] a threaded rod disposed on a surface of the second bearing;

[0037] a threaded pipe, the threaded pipe being threadedly connected to the surface of the threaded rod;

[0038] A turning handle is disposed on the surface of the threaded rod.

[0039] On the basis of the above scheme, the water outlet is connected to the first groove, each of the sliders is slidably connected to the first slide groove, each of the support columns is arranged on the surface of the first bearing plate, and the fixed shaft is fixedly connected to the first bearing.

[0040] (III) Beneficial effects

[0041] Compared with the prior art, the present invention provides a cooling device used in the cryopreservation of stem cells, which has the following beneficial effects:

[0042] In the cooling device used in the freezing process of stem cells, the staff starts the second motor, and the third supporting plate is driven to rotate by the rotation of the second motor. Then the first motor is started, and the telescopic rod and the first square tube are driven to rotate by the rotation of the first motor, so that the fixed shaft rotates in the second slide groove, so that the supporting tube rotates back and forth, so that the stem cells and the freezing liquid are mixed more evenly and the survival time of the stem cells is prolonged. Finally, the staff turns the rotating handle, and the threaded rod is rotated by turning the rotating handle, so that the lifting frame is raised and lowered, so that the staff can store the stem cells conveniently. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0044] Figure 2 It is a schematic diagram of the structure of the side section of the utility model;

[0045] Figure 3 For this utility model Figure 2 A schematic diagram of the local enlarged structure at B in the middle;

[0046] Figure 4 It is a schematic structural diagram of the oblique cross section of the utility model;

[0047] Figure 5 For this utility model Figure 1 Schematic diagram of the local enlarged structure at point A in the middle.

[0048] In the figure: 1. storage barrel; 2. water tank; 3. vent hole; 4. rubber cover; 5. barometer; 6. first bearing plate; 7. connecting block; 8. connecting rod; 9. slider; 10. first motor; 11. first square tube; 12. fixed shaft; 13. first bearing; 14. second bearing plate; 15. telescopic rod; 16. support column; 17. bearing rod; 18. second motor; 19. third bearing plate; 20. bearing tube; 21. lifting frame; 22. fixed block; 23. second bearing; 24. threaded rod; 25. threaded tube; 26. turning handle. DETAILED DESCRIPTION

[0049] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0050] See also Figures 1 to 5A cooling device used in the freezing process of stem cells includes a storage barrel 1, and also includes a water tank 2 fixedly connected to the surface of the storage barrel 1. The function of the water tank 2 is to facilitate the storage of liquid nitrogen. The water outlet is arranged on the surface of the water tank 2. The function of the water outlet is to facilitate the liquid nitrogen to flow into the first groove. The first groove is arranged on the surface of the storage barrel 1. The air vent 3 is arranged on the surface of the storage barrel 1. The function of the air vent 3 is to discharge the gas formed by the liquid nitrogen when it is gasified to prevent the danger caused by excessive air pressure in the first groove. The rubber cover 4 is fixedly connected to the surface of the first groove. The barometer 5 is fixedly connected to the surface of the storage barrel 1. The function of the barometer 5 is to facilitate the observation of the air pressure in the first groove. The first groove is arranged on the surface of the storage barrel 1. The first bearing plate 6 is placed on the surface of the storage barrel 1. Each connecting block 7 is fixedly connected to the surface of the first bearing plate 6. Each connecting rod 8 is respectively fixedly connected to the surface of the connecting block 7. The function of the connecting block 7 The purpose is to make the force on the first bearing plate 6 more uniform, so as to avoid the inability to lift or lower due to uneven force during lifting. Each slider 9 is fixedly connected to the surface of the first bearing plate 6. The function of the slider 9 is to prevent the first bearing plate 6 from following the rotation when the first motor 10 is started, so as to improve the stability of the device. The first motor 10 is fixedly connected to the surface of the first bearing plate 6, and the second slide groove is opened on the surface of the second bearing plate 14. The first square tube 11 is fixedly connected to the surface of the output end of the first motor 10, and the telescopic rod 15 is slidably connected to the surface of the first square tube 11. The function of the telescopic rod 15 is to facilitate the sliding of the bearing rod 17 on the surface of the second slide groove. The fixed shaft 12 is fixedly connected to the surface of the first square tube 11, and each support column 16 is fixedly connected to the surface of the second bearing plate 14. The first bearing 13 is fixedly connected to the surface of the fixed shaft 12, and the first bearing plate 6 is fixedly connected to the surface of the first bearing 13.

[0051] The bearing rod 17 is fixedly connected to the surface of the telescopic rod 15. The function of the bearing rod 17 is to carry the second motor 18. The second motor 18 is fixedly connected to the surface of the bearing rod 17. The third bearing plate 19 is fixedly connected to the surface of the output end of the second motor 18. Each second groove is opened on the surface of the third bearing plate 19. Each bearing tube 20 is placed on the surface of the corresponding second groove. The lifting frame 21 is fixedly connected to the surface of the connecting block 7. The fixed block 22 is fixedly connected to the surface of the storage barrel 1. The second bearing 23 is fixedly connected to the surface of the fixed block 22. The threaded rod 24 is fixedly connected to the surface of the second bearing 23. The threaded tube 25 is threadedly connected to the surface of the threaded rod 24. The rotating handle 26 is fixedly connected to the surface of the threaded rod 24. The water outlet is connected to the first groove. Each slider 9 is slidably connected to the first slide groove. Each support column 16 is fixedly connected to the surface of the first bearing plate 6. The fixed shaft 12 is fixedly connected to the first bearing 13.

[0052] Working principle:

[0053] When using the cooling device used in the freezing process of stem cells, first place the cooling device used in the freezing process of stem cells at the desired location, first a staff member opens the water outlet to allow the liquid nitrogen in the water tank 2 to enter the first groove through the water outlet, then the staff member starts the second motor 18, and the third bearing plate 19 is driven to rotate by the rotation of the second motor 18, and then the first motor 10 is started, and the telescopic rod 15 and the first square tube 11 are driven to rotate by the rotation of the first motor 10, so that the fixed shaft 12 is rotated in the second slide groove, so that the bearing tube 20 is rotated back and forth, so that the stem cells and the freezing solution are mixed more evenly and the survival time of the stem cells is prolonged, and finally, the staff member rotates the rotating handle 26, and the threaded rod 24 is rotated by rotating the rotating handle 26, so that the lifting frame 21 is lifted and lowered, so that the staff member can store the stem cells conveniently.

[0054] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A cooling device for use in a stem cell cryopreservation process, comprising a storage barrel (1), characterized in that: Also includes A water tank (2), wherein the water tank (2) is arranged on the surface of the storage barrel (1); A water outlet, the water outlet being provided on the surface of the water tank (2); A first groove, the first groove being formed on the surface of the storage barrel (1); A vent hole (3), wherein the vent hole (3) is provided on the surface of the storage barrel (1); A rubber cover (4), wherein the rubber cover (4) is arranged on the surface of the first groove; A barometer (5) is provided on the surface of the storage barrel (1).

2. The cooling device used in the cryopreservation of stem cells according to claim 1, characterized in that: A first groove, wherein the first groove is formed on the surface of the storage barrel (1); A first carrying plate (6), the first carrying plate (6) being arranged on the surface of the storage barrel (1); A plurality of connection blocks (7), each of the connection blocks (7) being arranged on the surface of the first carrying plate (6); A plurality of connecting rods (8), each of the connecting rods (8) being arranged on a surface of the connecting block (7); Two sliders (9), each of which is arranged on the surface of the first carrying plate (6).

3. The cooling device used in the cryopreservation of stem cells according to claim 2, characterized in that: A first motor (10), the first motor (10) being arranged on a surface of a first carrying plate (6); A first square tube (11), the first square tube (11) being arranged on a surface of an output end of the first motor (10); A fixed shaft (12), wherein the fixed shaft (12) is arranged on the surface of the first square tube (11); A first bearing (13), the first bearing (13) being arranged on a surface of the fixed shaft (12); A second bearing plate (14), the second bearing plate (14) being arranged on a surface of the first bearing (13); A second slide groove, wherein the second slide groove is provided on the surface of the second carrying plate (14); A telescopic rod (15), wherein the telescopic rod (15) is arranged on the surface of the first square tube (11); Two support columns (16), each of the support columns (16) is arranged on the surface of the second carrying plate (14).

4. The cooling device used in the cryopreservation of stem cells according to claim 3, characterized in that: A bearing rod (17), wherein the bearing rod (17) is arranged on the surface of the telescopic rod (15); A second motor (18), the second motor (18) being arranged on the surface of the bearing rod (17); a third bearing plate (19), the third bearing plate (19) being arranged on a surface of an output end of the second motor (18); A plurality of second grooves, each of the second grooves is disposed on the surface of the third supporting plate (19); A plurality of supporting tubes (20), each supporting tube (20) being arranged on the surface of a corresponding second groove.

5. The cooling device used in the cryopreservation of stem cells according to claim 1, characterized in that: A lifting frame (21), wherein the lifting frame (21) is arranged on the surface of the connecting block (7); A fixing block (22), wherein the fixing block (22) is arranged on the surface of the storage barrel (1); A second bearing (23), the second bearing (23) being arranged on a surface of the fixing block (22); a threaded rod (24), wherein the threaded rod (24) is disposed on a surface of the second bearing (23); A threaded tube (25), wherein the threaded tube (25) is threadedly connected to the surface of the threaded rod (24); A rotating handle (26) is provided on the surface of the threaded rod (24).

6. The cooling device used in the cryopreservation of stem cells according to claim 3, characterized in that: The water outlet is communicated with the first groove, each of the sliders (9) is slidably connected to the first slide groove, each of the support columns (16) is arranged on the surface of the first bearing plate (6), and the fixed shaft (12) is fixedly connected to the first bearing (13).

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